TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 465.468 | Formula: C27H33BrN2
H donors: 0 H acceptors: 1 LogP: 6.59 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: N#CC(c1ccccc1)(c1ccccc1)C[C@@H]1CC2CCC(C1)[N@+]2(C)CC1CC1.[Br-]
InChi: 1S/C27H33N2.BrH/c1-29(19-21-12-13-21)25-14-15-26(29)17-22(16-25)18-27(20-28,23-8-4-2-5-9-23)24-10-6-3-7-11-24;/h2-11,21-22,25-26H,12-19H2,1H3;1H/q+1;/p-1/t22-,25?,26?,29-;
InChiKey: XKRKFRNMCTYSTF-GLDYSVIMSA-M

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cholinergic receptor, muscarinic 3	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_133264	All targets in OG5_133264
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_133264	All targets in OG5_133264

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	RE15519p	0.0105	0.0156	0.0154
Schistosoma mansoni	neuropeptide receptor	0.0105	0.0156	0.0154
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0672	0.1212	0.1212
Brugia malayi	ORL1-like opioid receptor	0.0105	0.0156	0.0154
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3221	0.596	0.5959
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0156	0.0154
Loa Loa (eye worm)	phosphatidylinositol 3	0.0348	0.0608	0.0607
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0156	0.0154
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3189	0.59	0.5899
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0348	0.0608	0.0795
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0023	0.0004	0.0004
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0348	0.0608	0.0607
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.5391	1	1
Schistosoma mansoni	hypothetical protein	0.0348	0.0608	0.0607
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0156	0.0154
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0105	0.0156	0.0156
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0105	0.0156	0.0154
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0348	0.0608	0.0608
Entamoeba histolytica	protein kinase rad3, putative	0.102	0.186	0.186
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0156	0.0154
Echinococcus granulosus	somatostatin receptor	0.0105	0.0156	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0142	0.014
Leishmania major	hypothetical protein, unknown function	0.0348	0.0608	0.0544
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0105	0.0156	0.0156
Brugia malayi	hypothetical protein	0.0105	0.0156	0.0154
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0348	0.0608	1
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0156	0.0154
Trichomonas vaginalis	PIKK family atypical protein kinase	0.102	0.186	0.1858
Loa Loa (eye worm)	phosphatidylinositol 3	0.1808	0.3327	0.3326
Schistosoma mansoni	fkbp-rapamycin associated protein	0.102	0.186	0.1858
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.5391	1	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0105	0.0156	0.0154
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1808	0.3327	0.3326
Echinococcus granulosus	biogenic amine 5HT receptor	0.0105	0.0156	0.0156
Echinococcus multilocularis	fmrfamide receptor	0.0105	0.0156	0.0156
Brugia malayi	Protein kinase domain containing protein	0.0034	0.0024	0.0022
Loa Loa (eye worm)	hypothetical protein	0.1136	0.2076	0.2075
Brugia malayi	larval opioid receptor	0.0105	0.0156	0.0154
Echinococcus multilocularis	g protein coupled receptor	0.0105	0.0156	0.0156
Echinococcus granulosus	serine/threonine protein kinase	0.0023	0.0004	0.0004
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0348	0.0608	0.0607
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0112	0.017	0.0168
Loa Loa (eye worm)	phosphatidylinositol 3	0.0348	0.0608	0.0607
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0156	0.0154
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0058	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0156	0.0154
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0105	0.0156	0.0154
Echinococcus multilocularis	G protein coupled receptor 139	0.0105	0.0156	0.0156
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0105	0.0156	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0156	0.0154
Trichomonas vaginalis	PIKK family atypical protein kinase	0.102	0.186	0.1858
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0156	0.0154
Brugia malayi	neuropeptide F receptor	0.0105	0.0156	0.0154
Schistosoma mansoni	hypothetical protein	0.0105	0.0156	0.0154
Loa Loa (eye worm)	phosphatidylinositol 3	0.0348	0.0608	0.0607
Loa Loa (eye worm)	hypothetical protein	0.1099	0.2007	0.2005
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0348	0.0608	0.0607
Schistosoma mansoni	voltage-gated potassium channel	0.0032	0.0021	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0156	0.0154
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59	0.0058	0.0068	0.0066
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0105	0.0156	0.0156
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0105	0.0156	0.0156
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0348	0.0608	0.0608
Brugia malayi	putative neuropeptide receptor	0.0105	0.0156	0.0154
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4288	0.7946	0.7945
Entamoeba histolytica	hypothetical protein	0.0348	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0605	0.1087	0.1085
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2911	0.5382	0.5381
Trichomonas vaginalis	PIKK family atypical protein kinase	0.401	0.7427	0.7427
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.102	0.186	0.1858
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0105	0.0156	0.0154
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0348	0.0608	1
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0348	0.0608	0.0607
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0348	0.0608	0.0607
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0032	0.0021	0.0019
Entamoeba histolytica	hypothetical protein	0.0348	0.0608	0.0608
Echinococcus multilocularis	serotonin receptor	0.0105	0.0156	0.0156
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0105	0.0156	0.0154
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0024	0.0022
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4603	0.8532	0.8532
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0022	0.0002	0.0002
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0105	0.0156	0.0154
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0348	0.0608	0.0608
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0058	0.0068	0.0068
Schistosoma mansoni	hypothetical protein	0.0105	0.0156	0.0154
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0105	0.0156	0.0154
Brugia malayi	Dopamine receptor protein 1	0.0105	0.0156	0.0154
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0348	0.0608	0.0795
Echinococcus multilocularis	fmrfamide receptor	0.0105	0.0156	0.0156
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0058	0.0068	0.0066
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.5391	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0024	0.0022
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0105	0.0156	0.0154
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0105	0.0156	0.0156
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0105	0.0156	0.0156
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.005	0.0053	0.0053
Schistosoma mansoni	biogenic amine receptor	0.0105	0.0156	0.0154
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0112	0.017	0.0168
Schistosoma mansoni	neuropeptide receptor	0.0105	0.0156	0.0154
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0348	0.0608	0.0608
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0105	0.0156	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0156	0.0154
Brugia malayi	Melatonin receptor type 1A	0.0105	0.0156	0.0154
Echinococcus granulosus	tm gpcr rhodopsin	0.0105	0.0156	0.0156
Echinococcus multilocularis	fk506 binding protein	0.0058	0.0068	0.0068
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0105	0.0156	0.0154
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0105	0.0156	0.0154
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0348	0.0608	0.0607
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.5391	1	1
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.1808	0.3327	0.3327
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0672	0.1212	0.121
Schistosoma mansoni	immunophilin FK506 binding protein FKBP12	0.0058	0.0068	0.0066
Echinococcus granulosus	neuropeptide receptor	0.0105	0.0156	0.0156
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0348	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0156	0.0154
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.2239	0.4131	0.4117
Loa Loa (eye worm)	hypothetical protein	0.005	0.0053	0.0051
Brugia malayi	GnHR receptor homolog	0.0105	0.0156	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0156	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0156	0.0154
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type, putative	0.0058	0.0068	0.0068
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.102	0.186	0.186
Trypanosoma cruzi	Protein kinase B	0.0023	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0672	0.1212	0.121
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0105	0.0156	0.0154
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0348	0.0608	0.0608
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1808	0.3327	0.3326
Giardia lamblia	70 kDa peptidylprolyl isomerase, putative	0.0058	0.0068	0.0068
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0105	0.0156	0.0154
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2907	0.5373	0.5372
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3221	0.596	0.5959
Echinococcus multilocularis	neuropeptide receptor	0.0105	0.0156	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0156	0.0154
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0348	0.0608	0.0586
Toxoplasma gondii	target of rapamycin (TOR), putative	0.401	0.7427	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0105	0.0156	0.0156
Echinococcus granulosus	voltage gated potassium channel	0.0032	0.0021	0.0021
Entamoeba histolytica	protein kinase, putative	0.0034	0.0024	0.0024
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5391	1	1
Trichomonas vaginalis	fk506-binding protein, putative	0.0058	0.0068	0.0066
Echinococcus granulosus	neuropeptide s receptor	0.0105	0.0156	0.0156
Echinococcus granulosus	rhodopsin orphan GPCR	0.0105	0.0156	0.0156
Echinococcus multilocularis	neuropeptide receptor A26	0.0105	0.0156	0.0156
Brugia malayi	hypothetical protein	0.0105	0.0156	0.0154
Echinococcus granulosus	neuropeptide receptor	0.0105	0.0156	0.0156
Brugia malayi	p70 ribosomal S6 kinase beta	0.0032	0.002	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0156	0.0154
Brugia malayi	hypothetical protein	0.0105	0.0156	0.0154
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0105	0.0156	0.0156
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0105	0.0156	0.0154
Schistosoma mansoni	neuropeptide receptor	0.0105	0.0156	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0156	0.0154
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0105	0.0156	0.0156
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0023	0.0004	0.0004
Echinococcus granulosus	g protein coupled receptor	0.0105	0.0156	0.0156
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0112	0.017	0.017
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0348	0.0608	0.0607
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0348	0.0608	0.0544
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4288	0.7946	0.7945
Echinococcus multilocularis		0.0348	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0156	0.0154
Echinococcus granulosus	allatostatin A receptor	0.0105	0.0156	0.0156
Loa Loa (eye worm)	neuropeptide F receptor	0.0105	0.0156	0.0154
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0105	0.0156	0.0154
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0348	0.0608	0.0607
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.5391	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0105	0.0156	0.0156
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0105	0.0156	0.0154
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.005	0.0053	0.0053
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3221	0.596	0.5959
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.5391	1	1
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0348	0.0608	0.0607
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0105	0.0156	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0156	0.0154
Echinococcus granulosus	hyperpolarization activated cyclic	0.0022	0.0002	0.0002
Echinococcus granulosus	rhodopsin orphan GPCR	0.0105	0.0156	0.0156
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0105	0.0156	0.0156
Brugia malayi	hypothetical protein	0.0105	0.0156	0.0154
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0348	0.0608	0.0607
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0058	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0156	0.0154
Echinococcus granulosus	orexin receptor type 2	0.0105	0.0156	0.0156
Brugia malayi	hypothetical protein	0.0105	0.0156	0.0154
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5391	1	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0105	0.0156	0.0156
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0348	0.0608	0.0608
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0105	0.0156	0.0154
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.0058	0.0068	0.0044
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0105	0.0156	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0156	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0156	0.0154
Schistosoma mansoni	voltage-gated potassium channel	0.0122	0.0189	0.0187
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0348	0.0608	0.0607
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0348	0.0608	0.0608
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0348	0.0608	0.0607
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0105	0.0156	0.0154
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0348	0.0608	0.0607
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0156	0.0154
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1808	0.3327	0.3326
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0022	0.0002	0.0002
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.5391	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0105	0.0156	0.0156
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0348	0.0608	1
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0348	0.0608	0.0795
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0105	0.0156	0.0156
Echinococcus granulosus	neuropeptide Y receptor	0.0105	0.0156	0.0156
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0032	0.0021	0.0021
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4288	0.7946	0.7945
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0348	0.0608	0.0607
Schistosoma mansoni	histamine h1 receptor	0.0105	0.0156	0.0154
Plasmodium falciparum	peptidyl-prolyl cis-trans isomerase FKBP35	0.0058	0.0068	0.1116
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-12	0.0058	0.0068	0.0066
Loa Loa (eye worm)	G-protein coupled receptor	0.0105	0.0156	0.0154
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2911	0.5382	0.5381
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0348	0.0608	0.0586
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0105	0.0156	0.0156
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2907	0.5373	0.5372
Leishmania major	phosphatidylinositol 3-kinase, putative	0.1808	0.3327	0.3282
Entamoeba histolytica	hypothetical protein	0.102	0.186	0.186
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0105	0.0156	0.0156
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0348	0.0608	0.0607
Trichomonas vaginalis	PIKK family atypical protein kinase	0.401	0.7427	0.7427
Brugia malayi	hypothetical protein	0.0105	0.0156	0.0154
Echinococcus granulosus	sex peptide receptor	0.0105	0.0156	0.0156
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0105	0.0156	0.0154
Echinococcus granulosus	rhodopsin orphan GPCR	0.0105	0.0156	0.0156
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0105	0.0156	0.0154
Loa Loa (eye worm)	melatonin receptor type 1A	0.0105	0.0156	0.0154
Echinococcus multilocularis	g-protein coupled receptor	0.0105	0.0156	0.0156
Echinococcus multilocularis	allatostatin A receptor	0.0105	0.0156	0.0156
Trypanosoma brucei	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0058	0.0068	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0156	0.0154
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.0058	0.0068	0.5
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0348	0.0608	0.0608
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0105	0.0156	0.0156
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.102	0.186	0.186
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0156	0.0154
Brugia malayi	follicle stimulating hormone receptor	0.0105	0.0156	0.0154
Brugia malayi	sulfakinin receptor protein	0.0105	0.0156	0.0154
Loa Loa (eye worm)	phosphatidylinositol 3	0.5391	1	1
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0156	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0348	0.0608	0.0607
Schistosoma mansoni	hypothetical protein	0.0105	0.0156	0.0154
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0348	0.0608	1
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12	0.0058	0.0068	0.0066
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0348	0.0608	0.0544
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0156	0.0154
Echinococcus granulosus	hyperpolarization activated cyclic	0.0022	0.0002	0.0002
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0105	0.0156	0.0154
Trichomonas vaginalis	PIKK family atypical protein kinase	0.401	0.7427	0.7427
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0023	0.0004	0.0004
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0105	0.0156	0.0154
Brugia malayi	putative neuropeptide receptor NPR1	0.0105	0.0156	0.0154
Brugia malayi	FAT domain containing protein	0.0788	0.1429	0.1427
Schistosoma mansoni	voltage-gated potassium channel	0.0032	0.0021	0.0019
Schistosoma mansoni	immunophilin	0.005	0.0053	0.0051
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0105	0.0156	0.0156
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0348	0.0608	0.0608
Brugia malayi	G-protein coupled receptor	0.0105	0.0156	0.0154
Brugia malayi	hypothetical protein	0.0105	0.0156	0.0154
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0105	0.0156	0.0154
Echinococcus multilocularis	neuropeptides capa receptor	0.0105	0.0156	0.0156
Schistosoma mansoni	biogenic amine receptor	0.0105	0.0156	0.0154
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0022	0.0002	0.0002
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0348	0.0608	1
Echinococcus granulosus	fmrfamide receptor	0.0105	0.0156	0.0156
Leishmania major	hypothetical protein, conserved	0.0348	0.0608	0.0544
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0348	0.0608	0.0608
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0105	0.0156	0.0154
Brugia malayi	Serotonin receptor	0.0105	0.0156	0.0154
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0348	0.0608	0.0607
Loa Loa (eye worm)	hypothetical protein	0.0788	0.1429	0.1427
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0348	0.0608	0.0607
Loa Loa (eye worm)	phosphatidylinositol 3	0.0348	0.0608	0.0607
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2907	0.5373	0.5372
Echinococcus multilocularis	rac serine:threonine kinase	0.0023	0.0004	0.0004
Trichomonas vaginalis	PIKK family atypical protein kinase	0.401	0.7427	0.7427
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2911	0.5382	0.5381
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0156	0.0154
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0348	0.0608	0.0608
Echinococcus multilocularis	g protein coupled receptor	0.0105	0.0156	0.0156
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0105	0.0156	0.0156
Onchocerca volvulus		0.0348	0.0608	1
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0348	0.0608	0.0608
Schistosoma mansoni	immunophilin	0.0058	0.0068	0.0066
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0105	0.0156	0.0154
Schistosoma mansoni	hypothetical protein	0.0788	0.1429	0.1427
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0022	0.0002	0.0002
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0105	0.0156	0.0154
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0348	0.0608	0.0586
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0024	0.0022
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0105	0.0156	0.0156
Loa Loa (eye worm)	FKBP5 protein	0.0058	0.0068	0.0066
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.102	0.186	0.1858
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0156	0.0154
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1808	0.3327	0.3326
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0105	0.0156	0.0154
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0105	0.0156	0.0156
Brugia malayi	hypothetical protein	0.0105	0.0156	0.0154
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0348	0.0608	0.0608
Echinococcus granulosus	rhodopsin orphan GPCR	0.0105	0.0156	0.0156
Schistosoma mansoni	amine GPCR	0.0105	0.0156	0.0154
Entamoeba histolytica	protein kinase, putative	0.0034	0.0024	0.0024
Echinococcus granulosus	g-protein coupled receptor	0.0105	0.0156	0.0156
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0105	0.0156	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0156	0.0154
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0348	0.0608	0.0608
Trichomonas vaginalis	conserved hypothetical protein	0.0672	0.1212	0.121
Schistosoma mansoni	neuropeptide receptor	0.0105	0.0156	0.0154
Echinococcus granulosus	dro:myosuppressin receptor	0.0105	0.0156	0.0156
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3189	0.59	0.5899
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0022	0.0002	0.0002
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1446	0.2654	0.2653
Echinococcus multilocularis	serotonin receptor	0.0105	0.0156	0.0156
Brugia malayi	neuropeptide F receptor	0.0105	0.0156	0.0154
Trichomonas vaginalis	conserved hypothetical protein	0.0788	0.1429	0.1427
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0105	0.0156	0.0154
Schistosoma mansoni	amine GPCR	0.0105	0.0156	0.0154
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0022	0.0002	0.0002
Echinococcus granulosus	tm gpcr rhodopsin	0.0105	0.0156	0.0156
Echinococcus multilocularis	neuropeptide Y receptor	0.0105	0.0156	0.0156
Brugia malayi	G protein-coupled receptor	0.0105	0.0156	0.0154
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0105	0.0156	0.0156
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0348	0.0608	0.0608
Onchocerca volvulus		0.0348	0.0608	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0105	0.0156	0.0154
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0348	0.0608	0.0608
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.1808	0.3327	0.3282
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.5391	1	1
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0156	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0605	0.1087	0.1085
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0348	0.0608	0.0544
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.102	0.186	0.1858
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0348	0.0608	0.0608
Echinococcus granulosus	g protein coupled receptor	0.0105	0.0156	0.0156
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.1808	0.3327	0.3327
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0348	0.0608	0.0586
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0105	0.0156	0.0154
Giardia lamblia	FKBP-type peptidyl-prolyl cis-trans isomerase	0.0058	0.0068	0.0068
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0348	0.0608	0.0607
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0156	0.0154
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0348	0.0608	0.0608
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0348	0.0608	0.0607
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.0058	0.0068	0.5
Echinococcus granulosus	neuropeptide FF receptor 2	0.0105	0.0156	0.0156
Schistosoma mansoni	amine GPCR	0.0105	0.0156	0.0154
Echinococcus granulosus	G protein coupled receptor 139	0.0105	0.0156	0.0156
Plasmodium vivax	hypothetical protein	0.0348	0.0608	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0105	0.0156	0.0154
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0105	0.0156	0.0156
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0058	0.0068	0.0068
Echinococcus multilocularis	neuropeptide s receptor	0.0105	0.0156	0.0156
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0105	0.0156	0.0156
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0105	0.0156	0.0156
Loa Loa (eye worm)	TYRA-2 protein	0.0105	0.0156	0.0154
Echinococcus granulosus	biogenic amine 5HT receptor	0.0105	0.0156	0.0156
Schistosoma mansoni	myosin xvIII	0.0105	0.0156	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0156	0.0154
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0348	0.0608	0.0607
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.5391	1	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0105	0.0156	0.0156
Schistosoma mansoni	opsin-like receptor	0.0105	0.0156	0.0154
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0348	0.0608	0.0607
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.1808	0.3327	0.3312
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0032	0.0021	0.0021
Plasmodium vivax	hypothetical protein, conserved	0.0348	0.0608	1
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.4292	0.7954	0.794
Loa Loa (eye worm)	neuropeptide F receptor	0.0105	0.0156	0.0154
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0105	0.0156	0.0156
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0105	0.0156	0.0154
Trichomonas vaginalis	immunophilin, putative	0.0058	0.0068	0.0066
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0348	0.0608	0.0795
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.102	0.186	0.186
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0156	0.0154
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0348	0.0608	0.0608
Entamoeba histolytica	protein kinase, putative	0.0032	0.002	0.002
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.5391	1	1
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0348	0.0608	1
Echinococcus multilocularis	neuropeptide receptor	0.0105	0.0156	0.0156
Brugia malayi	hypothetical protein	0.0105	0.0156	0.0154
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0348	0.0608	0.0608
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0024	0.0022
Echinococcus granulosus	neuropeptide Y receptor	0.0105	0.0156	0.0156
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.102	0.186	0.186
Echinococcus granulosus	serotonin receptor	0.0105	0.0156	0.0156
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0105	0.0156	0.0154
Trypanosoma cruzi	target of rapamycin kinase 3	0.4292	0.7954	0.7954
Echinococcus multilocularis	orexin receptor type 2	0.0105	0.0156	0.0156
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0105	0.0156	0.0154
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0348	0.0608	0.0607
Brugia malayi	Dopamine receptor protein 2	0.0105	0.0156	0.0154
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0105	0.0156	0.0156
Schistosoma mansoni	adenoreceptor	0.0105	0.0156	0.0154
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0348	0.0608	0.0607
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0348	0.0608	0.0608
Echinococcus multilocularis	Zinc finger, PHD finger	0.0348	0.0608	0.0608
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0348	0.0608	0.0795
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0024	0.0022
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0105	0.0156	0.0156
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5391	1	1
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.4292	0.7954	0.7949
Schistosoma mansoni	serine/threonine-protein kinase	0.0023	0.0004	0.0002
Schistosoma mansoni	opsin-like receptor	0.0105	0.0156	0.0154
Entamoeba histolytica	hypothetical protein	0.0348	0.0608	0.0608
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0348	0.0608	0.0608
Echinococcus multilocularis	somatostatin receptor	0.0105	0.0156	0.0156
Echinococcus multilocularis	neuropeptide Y receptor	0.0105	0.0156	0.0156
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0348	0.0608	0.0607
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0348	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0156	0.0154
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.102	0.186	0.184
Trichomonas vaginalis	PIKK family atypical protein kinase	0.102	0.186	0.1858
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.1808	0.3327	0.3327
Giardia lamblia	Hypothetical protein	0.0348	0.0608	0.0608
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1808	0.3327	0.3326
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0348	0.0608	0.0607
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0022	0.0002	0.0002
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4288	0.7946	0.7945
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0024	0.0022
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0034	0.0024	0.0022
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.1808	0.3327	0.3327
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0348	0.0608	0.0607
Echinococcus granulosus	7TM GPCR rhodopsin	0.0105	0.0156	0.0156
Brugia malayi	AKH receptor	0.0105	0.0156	0.0154
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0348	0.0608	0.0608
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.1808	0.3327	0.3326
Schistosoma mansoni	opsin-like receptor	0.0105	0.0156	0.0154
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0022	0.0002	0.0002
Schistosoma mansoni	voltage-gated potassium channel	0.0122	0.0189	0.0187
Echinococcus granulosus	rhodopsin orphan GPCR	0.0105	0.0156	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0156	0.0154
Brugia malayi	G-protein coupled receptor	0.0105	0.0156	0.0154
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0105	0.0156	0.0156
Schistosoma mansoni	amine GPCR	0.0105	0.0156	0.0154
Giardia lamblia	GTOR	0.5391	1	1
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0156	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0156	0.0154
Plasmodium vivax	70 kDa peptidylprolyl isomerase, putative	0.0058	0.0068	0.1116
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1808	0.3327	0.3326
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0105	0.0156	0.0156
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0032	0.002	0.0018
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.1808	0.3327	0.3312
Trichomonas vaginalis	PIKK family atypical protein kinase	0.35	0.6478	0.6477
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0348	0.0608	0.0607
Echinococcus multilocularis	voltage gated potassium channel	0.0032	0.0021	0.0021
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type , putative	0.0058	0.0068	0.0068
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2911	0.5382	0.5381
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0348	0.0608	0.0608
Toxoplasma gondii	FATC domain-containing protein	0.102	0.186	0.2484
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0105	0.0156	0.0154
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0348	0.0608	0.0608
Entamoeba histolytica	hypothetical protein	0.0348	0.0608	0.0608
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0348	0.0608	0.0608
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0105	0.0156	0.0154
Loa Loa (eye worm)	hypothetical protein	0.102	0.186	0.1858
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0348	0.0608	0.0608
Loa Loa (eye worm)	G-protein coupled receptor	0.0105	0.0156	0.0154
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.2549	0.4708	0.4696
Echinococcus granulosus	neuropeptide receptor A26	0.0105	0.0156	0.0156
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0105	0.0156	0.0154
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4288	0.7946	0.7945
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0348	0.0608	0.5
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP1A	0.0058	0.0068	0.0068
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0105	0.0156	0.0156
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0348	0.0608	0.0607
Echinococcus granulosus	hypothetical protein	0.0105	0.0156	0.0156
Echinococcus multilocularis	dro:myosuppressin receptor	0.0105	0.0156	0.0156
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0348	0.0608	0.0608
Schistosoma mansoni	biogenic amine receptor	0.0105	0.0156	0.0154
Schistosoma mansoni	hypothetical protein	0.0105	0.0156	0.0154
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.102	0.186	0.186
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0156	0.0154
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0348	0.0608	0.0608
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0105	0.0156	0.0156
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0348	0.0608	0.0607
Echinococcus multilocularis	serine protein kinase ATM	0.102	0.186	0.186
Schistosoma mansoni	immunophilin	0.0058	0.0068	0.0066
Echinococcus granulosus	neuropeptides capa receptor	0.0105	0.0156	0.0156
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0348	0.0608	0.0608
Echinococcus granulosus	neuropeptides capa receptor	0.0105	0.0156	0.0156
Echinococcus multilocularis	g protein coupled receptor	0.0105	0.0156	0.0156
Schistosoma mansoni	neuropeptide f receptor 76f	0.0105	0.0156	0.0154
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0788	0.1429	0.1429
Brugia malayi	G protein-coupled receptor F59B2.13	0.0105	0.0156	0.0154
Brugia malayi	hypothetical protein	0.0105	0.0156	0.0154
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0105	0.0156	0.0154
Loa Loa (eye worm)	phosphatidylinositol 3	0.0348	0.0608	0.0607
Brugia malayi	Serotonin receptor	0.0105	0.0156	0.0154
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.1136	0.2076	0.2776
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0021	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0156	0.0154
Brugia malayi	Dopamine receptor	0.0105	0.0156	0.0154
Schistosoma mansoni	neuropeptide F-like receptor	0.0105	0.0156	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0348	0.0608	0.0607
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0105	0.0156	0.0156
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0058	0.0068	0.0068
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0348	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0156	0.0154
Echinococcus multilocularis	neuropeptides capa receptor	0.0105	0.0156	0.0156
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0348	0.0608	0.0607
Trichomonas vaginalis	PIKK family atypical protein kinase	0.401	0.7427	0.7427
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0058	0.0068	0.0066
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0105	0.0156	0.0154
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0058	0.0068	0.0068
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0348	0.0608	0.0607
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0348	0.0608	0.0608
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0024	0.0022
Leishmania major	phosphatidylinositol kinase, putative	0.0348	0.0608	0.0544
Mycobacterium leprae	conserved hypothetical protein	0.0348	0.0608	0.5
Echinococcus multilocularis	sex peptide receptor	0.0105	0.0156	0.0156
Trichomonas vaginalis	PIKK family atypical protein kinase	0.401	0.7427	0.7427
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0112	0.017	0.017
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3616	0.6695	0.6694
Trichomonas vaginalis	PIKK family atypical protein kinase	0.401	0.7427	0.7427
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0348	0.0608	1
Schistosoma mansoni	amine GPCR	0.0105	0.0156	0.0154
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.5391	1	1
Echinococcus granulosus	g protein coupled receptor	0.0105	0.0156	0.0156
Echinococcus granulosus	serine protein kinase ATM	0.102	0.186	0.186
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0348	0.0608	0.0544
Schistosoma mansoni	serine/threonine-protein kinase	0.0023	0.0004	0.0002
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0348	0.0608	0.0608
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0788	0.1429	0.1429
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0022	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0156	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0156	0.0154
Trichomonas vaginalis	conserved hypothetical protein	0.1136	0.2076	0.2075

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	< 10 nM	Antagonist activity at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium mobilization by FLIPR analysis	ChEMBL.	22460029
Kd (functional)	= 10.6	Antagonist potency at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium mobilization by FLIPR analysis relative to control	ChEMBL.	22460029

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2023760

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1638475