Detailed information for compound 1638478

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 478.643 | Formula: C30H40NO4+
  • H donors: 1 H acceptors: 1 LogP: 8.36 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCc1c2[n+](CCc3c2cc(O)c(c3)OCCC)cc2c1ccc(c2OC)OC
  • InChi: 1S/C30H39NO4/c1-5-7-8-9-10-11-12-23-22-13-14-27(33-3)30(34-4)25(22)20-31-16-15-21-18-28(35-17-6-2)26(32)19-24(21)29(23)31/h13-14,18-20H,5-12,15-17H2,1-4H3/p+1
  • InChiKey: NEKKOGMNEKOLOA-UHFFFAOYSA-O  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0137 0.0225 0.0187
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0122 0.0194 0.0155
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0122 0.0194 0.0194
Loa Loa (eye worm) AGC/AKT protein kinase 0.0033 0.0004 0.0004
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0057 0.0056 0.0051
Echinococcus multilocularis shaker cognate 0.0122 0.0194 0.0155
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0306 0.0585 0.0581
Schistosoma mansoni voltage-gated potassium channel 0.0132 0.0216 0.0177
Echinococcus multilocularis ryanodine receptor 44f 0.0122 0.0194 0.0155
Mycobacterium tuberculosis Conserved hypothetical protein 0.0306 0.0585 0.5
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0122 0.0194 0.0194
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0057 0.0056 0.0051
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0306 0.0585 0.0581
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0137 0.0225 0.0187
Echinococcus granulosus sodium channel protein 0.0122 0.0194 0.0155
Echinococcus granulosus potassium voltage gated channel protein 0.0122 0.0194 0.0155
Brugia malayi ion channel NompC 0.0122 0.0194 0.0194
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0694 0.1407 0.1373
Echinococcus granulosus TRP transient receptor potential channel 0.0122 0.0194 0.0155
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0122 0.0194 0.0155
Schistosoma mansoni voltage-gated potassium channel 0.0122 0.0194 0.0155
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0898 0.1839 0.1807
Trichomonas vaginalis PIKK family atypical protein kinase 0.2559 0.5362 0.536
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0306 0.0585 0.0788
Loa Loa (eye worm) FKBP5 protein 0.0057 0.0056 0.0056
Echinococcus multilocularis transient receptor potential cation channel 0.0122 0.0194 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.2563 0.537 0.5368
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0306 0.0585 0.0548
Echinococcus multilocularis two pore calcium channel protein 2 0.0122 0.0194 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.3775 0.7941 0.794
Echinococcus multilocularis voltage gated potassium channel 0.0147 0.0247 0.0209
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0306 0.0585 0.0548
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0122 0.0194 0.0155
Echinococcus multilocularis transient receptor potential cation channel 0.0122 0.0194 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.1592 0.331 0.3308
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0898 0.1839 0.1839
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0898 0.1839 0.1835
Trichomonas vaginalis PIKK family atypical protein kinase 0.353 0.7421 0.742
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0306 0.0585 0.0532
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0306 0.0585 0.0548
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0122 0.0194 0.0155
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0122 0.0194 0.0194
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0898 0.1839 0.1839
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0105 0.0158 0.0153
Echinococcus granulosus transient receptor potential cation channel 0.0122 0.0194 0.0155
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0137 0.0225 0.0225
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0306 0.0585 0.0548
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0057 0.0056 0.0017
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0147 0.0247 0.0209
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0306 0.0585 0.0581
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0122 0.0194 0.0155
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0694 0.1407 0.1373
Schistosoma mansoni voltage-gated potassium channel 0.0122 0.0194 0.0155
Loa Loa (eye worm) hypothetical protein 0.0212 0.0385 0.0385
Trichomonas vaginalis PIKK family atypical protein kinase 0.3184 0.6686 0.6685
Trichomonas vaginalis PIKK family atypical protein kinase 0.353 0.7421 0.742
Loa Loa (eye worm) hypothetical protein 0.0306 0.0585 0.0585
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0057 0.0056 0.0017
Echinococcus granulosus transient receptor potential cation channel 0.0122 0.0194 0.0155
Entamoeba histolytica protein kinase, putative 0.0033 0.0004 0.0004
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0306 0.0585 0.0788
Echinococcus granulosus hyperpolarization activated cyclic 0.0137 0.0225 0.0187
Schistosoma mansoni voltage-gated potassium channel 0.0122 0.0194 0.0155
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0057 0.0056 0.0051
Echinococcus granulosus voltage dependent calcium channel 0.0122 0.0194 0.0155
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0122 0.0194 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.4746 1 1
Schistosoma mansoni hypothetical protein 0.0694 0.1407 0.1373
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0306 0.0585 0.0581
Echinococcus multilocularis potassium voltage gated channel protein 0.0122 0.0194 0.0155
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0122 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.1 0.2056 0.2056
Trichomonas vaginalis PIKK family atypical protein kinase 0.0898 0.1839 0.1835
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0306 0.0585 1
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0306 0.0585 0.0548
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0306 0.0585 0.0548
Loa Loa (eye worm) hypothetical protein 0.0137 0.0225 0.0225
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0122 0.0194 0.0155
Schistosoma mansoni vesicular amine transporter 0.0122 0.0194 0.0155
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1 0.2056 0.2771
Echinococcus granulosus transient receptor potential cation channel 0.0122 0.0194 0.0155
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.4746 1 1
Loa Loa (eye worm) ion channel NompC 0.0122 0.0194 0.0194
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0057 0.0056 0.0056
Loa Loa (eye worm) phosphatidylinositol 3 0.0306 0.0585 0.0585
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0306 0.0585 0.0585
Loa Loa (eye worm) hypothetical protein 0.0122 0.0194 0.0194
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0122 0.0194 0.0194
Echinococcus multilocularis hyperpolarization activated cyclic 0.0137 0.0225 0.0187
Loa Loa (eye worm) phosphatidylinositol 3 0.0306 0.0585 0.0585
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0306 0.0585 0.0585
Echinococcus granulosus potassium large conductance calcium activated 0.0122 0.0194 0.0155
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0306 0.0585 0.0581
Echinococcus multilocularis transient receptor potential cation channel 0.0122 0.0194 0.0155
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0306 0.0585 0.0532
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0122 0.0194 0.0155
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0306 0.0585 0.0585
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0306 0.0585 0.0581
Trichomonas vaginalis PIKK family atypical protein kinase 0.353 0.7421 0.742
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0122 0.0194 0.0194
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0306 0.0585 0.0585
Trichomonas vaginalis PIKK family atypical protein kinase 0.353 0.7421 0.742
Trichomonas vaginalis PIKK family atypical protein kinase 0.353 0.7421 0.742
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0306 0.0585 1
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0306 0.0585 0.0548
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1592 0.331 0.3308
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0137 0.0225 0.0187
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0122 0.0194 0.0194
Echinococcus multilocularis Zinc finger, PHD finger 0.0306 0.0585 0.0548
Leishmania major phosphatidylinositol 3-kinase, putative 0.1592 0.331 0.3273
Loa Loa (eye worm) voltage-gated potassium channel 0.0122 0.0194 0.0194
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0122 0.0194 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.3775 0.7941 0.794
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0306 0.0585 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1592 0.331 0.3273
Echinococcus granulosus sodium leak channel non selective protein 0.0122 0.0194 0.0155
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1592 0.331 0.3308
Trichomonas vaginalis PIKK family atypical protein kinase 0.2836 0.5949 0.5947
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0227 0.0416 0.0416
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0306 0.0585 0.0548
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.4746 1 1
Loa Loa (eye worm) hypothetical protein 0.0122 0.0194 0.0194
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0122 0.0194 0.0155
Schistosoma mansoni voltage-gated potassium channel 0.0122 0.0194 0.0155
Loa Loa (eye worm) hypothetical protein 0.0049 0.0039 0.0039
Giardia lamblia Hypothetical protein 0.0306 0.0585 0.0532
Leishmania major hypothetical protein, conserved 0.0122 0.0194 0.0139
Echinococcus granulosus potassium voltage gated channel protein 0.0122 0.0194 0.0155
Entamoeba histolytica hypothetical protein 0.0306 0.0585 0.0585
Echinococcus multilocularis transient receptor potential cation channel 0.0122 0.0194 0.0155
Giardia lamblia GTOR 0.4746 1 1
Onchocerca volvulus 0.0306 0.0585 1
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0137 0.0225 0.0187
Schistosoma mansoni transient receptor potential channel 4 0.0122 0.0194 0.0155
Loa Loa (eye worm) hypothetical protein 0.0122 0.0194 0.0194
Schistosoma mansoni immunophilin 0.0057 0.0056 0.0017
Loa Loa (eye worm) hypothetical protein 0.0122 0.0194 0.0194
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0306 0.0585 0.0532
Trypanosoma brucei target of rapamycin kinase 3, putative 0.3779 0.7949 0.7948
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0122 0.0194 0.0155
Echinococcus granulosus potassium voltage gated channel protein 0.0122 0.0194 0.0155
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0306 0.0585 0.0581
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0227 0.0416 0.0379
Loa Loa (eye worm) hypothetical protein 0.0122 0.0194 0.0194
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0122 0.0194 0.019
Schistosoma mansoni immunophilin 0.0057 0.0056 0.0017
Loa Loa (eye worm) phosphatidylinositol 3 0.0306 0.0585 0.0585
Loa Loa (eye worm) voltage-dependent calcium channel 0.0122 0.0194 0.0194
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0137 0.0225 0.0221
Entamoeba histolytica hypothetical protein 0.0306 0.0585 0.0585
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0306 0.0585 0.0532
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0306 0.0585 0.0585
Echinococcus granulosus serine protein kinase ATM 0.0898 0.1839 0.1807
Plasmodium vivax hypothetical protein, conserved 0.0306 0.0585 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.3775 0.7941 0.794
Echinococcus multilocularis serine protein kinase ATM 0.0898 0.1839 0.1807
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0306 0.0585 0.0548
Loa Loa (eye worm) hypothetical protein 0.0122 0.0194 0.0194
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0898 0.1839 0.1793
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1592 0.331 0.3284
Loa Loa (eye worm) hypothetical protein 0.0122 0.0194 0.0194
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0306 0.0585 0.0548
Trichomonas vaginalis PIKK family atypical protein kinase 0.2563 0.537 0.5368
Schistosoma mansoni fkbp-rapamycin associated protein 0.0898 0.1839 0.1807
Onchocerca volvulus 0.0306 0.0585 1
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0306 0.0585 0.0548
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.4746 1 1
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0306 0.0585 0.0532
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0306 0.0585 0.0581
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0306 0.0585 0.0532
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0057 0.0056 0.0017
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0122 0.0194 0.0155
Schistosoma mansoni voltage-gated potassium channel 0.0122 0.0194 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.3775 0.7941 0.794
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2245 0.4695 0.4693
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0306 0.0585 0.0532
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0306 0.0585 0.0581
Brugia malayi Transient-receptor-potential like protein 0.0122 0.0194 0.0194
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0137 0.0225 0.0187
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0122 0.0194 0.0155
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0057 0.0056 0.5
Toxoplasma gondii transporter, cation channel family protein 0.0122 0.0194 0.0261
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0122 0.0194 0.0194
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0122 0.0194 0.0155
Echinococcus granulosus calcium activated potassium channel 0.0122 0.0194 0.0156
Trichomonas vaginalis PIKK family atypical protein kinase 0.4746 1 1
Toxoplasma gondii hypothetical protein 0.0122 0.0194 0.0261
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0122 0.0194 0.0155
Schistosoma mansoni voltage-dependent calcium channel 0.0122 0.0194 0.0155
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0057 0.0056 0.0056
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0137 0.0225 0.0187
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0306 0.0585 0.0581
Trichomonas vaginalis PIKK family atypical protein kinase 0.1592 0.331 0.3308
Loa Loa (eye worm) calcium channel 0.0122 0.0194 0.0194
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.4746 1 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0057 0.0056 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.3081 0.6469 0.6467
Echinococcus multilocularis transient receptor potential cation channel 0.0122 0.0194 0.0155
Leishmania major phosphatidylinositol 4-kinase, putative 0.0306 0.0585 0.0532
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0306 0.0585 0.0548
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0227 0.0416 0.0379
Echinococcus granulosus hyperpolarization activated cyclic 0.0137 0.0225 0.0187
Loa Loa (eye worm) hypothetical protein 0.0122 0.0194 0.0194
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0122 0.0194 0.0155
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1592 0.331 0.3273
Trichomonas vaginalis PIKK family atypical protein kinase 0.0306 0.0585 0.0581
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0306 0.0585 1
Schistosoma mansoni transient receptor potential channel 0.0122 0.0194 0.0155
Echinococcus multilocularis sodium leak channel non selective protein 0.0122 0.0194 0.0155
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0122 0.0194 0.0155
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0122 0.0194 0.019
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0122 0.0194 0.0155
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0105 0.0158 0.0153
Schistosoma mansoni ryanodine receptor related 0.0122 0.0194 0.0155
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0306 0.0585 0.0532
Echinococcus multilocularis sodium channel protein 0.0122 0.0194 0.0155
Brugia malayi Cyclic-nucleotide gated cation channel 0.0137 0.0225 0.0225
Loa Loa (eye worm) hypothetical protein 0.0591 0.1189 0.1189
Schistosoma mansoni voltage-gated potassium channel 0.0122 0.0194 0.0155
Echinococcus multilocularis transfer RNA-Gly 0.0122 0.0194 0.0155
Giardia lamblia Phosphatidylinositol 4-kinase 0.0306 0.0585 0.0532
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.4746 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1592 0.331 0.331
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0137 0.0225 0.0187
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0122 0.0194 0.0139
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0057 0.0056 0.0056
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0122 0.0194 0.0155
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0306 0.0585 0.0581
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0122 0.0194 0.0261
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0306 0.0585 0.0585
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0122 0.0194 0.0194
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.4746 1 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1971 0.4116 0.4113
Leishmania major phosphatidylinositol 3-kinase, putative 0.0306 0.0585 0.0532
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0122 0.0194 0.0194
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0306 0.0585 0.0548
Trichomonas vaginalis PIKK family atypical protein kinase 0.1592 0.331 0.3308
Echinococcus multilocularis 0.0306 0.0585 0.0548
Brugia malayi cation channel family protein 0.0122 0.0194 0.0194
Trichomonas vaginalis PIKK family atypical protein kinase 0.4746 1 1
Echinococcus granulosus short transient receptor potential channel 6 0.0122 0.0194 0.0155
Echinococcus multilocularis potassium large conductance calcium activated 0.0122 0.0194 0.0155
Loa Loa (eye worm) ryanodine receptor 0.0122 0.0194 0.0194
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0306 0.0585 0.0585
Loa Loa (eye worm) voltage-gated potassium channel 0.0122 0.0194 0.0194
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0057 0.0056 0.0056
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1592 0.331 0.3284
Echinococcus multilocularis voltage dependent calcium channel 0.0122 0.0194 0.0155
Plasmodium vivax hypothetical protein 0.0306 0.0585 1
Schistosoma mansoni voltage-gated cation channel 0.0122 0.0194 0.0155
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0306 0.0585 0.0581
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0898 0.1839 0.1807
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0306 0.0585 0.0788
Loa Loa (eye worm) hypothetical protein 0.0147 0.0247 0.0247
Brugia malayi voltage-dependent calcium channel 0.0122 0.0194 0.0194
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0306 0.0585 0.0585
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0122 0.0194 0.0194
Trichomonas vaginalis fk506-binding protein, putative 0.0057 0.0056 0.0051
Brugia malayi cation channel family protein 0.0122 0.0194 0.0194
Schistosoma mansoni voltage-gated potassium channel 0.0122 0.0194 0.0155
Echinococcus multilocularis potassium voltage gated channel protein 0.0122 0.0194 0.0155
Toxoplasma gondii transporter, cation channel family protein 0.0122 0.0194 0.0261
Echinococcus granulosus ryanodine receptor 44f 0.0122 0.0194 0.0155
Schistosoma mansoni voltage-gated potassium channel 0.0237 0.0438 0.0401
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0306 0.0585 0.0585
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0306 0.0585 0.0532
Schistosoma mansoni voltage-gated potassium channel 0.0147 0.0247 0.0209
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0122 0.0194 0.0155
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0306 0.0585 0.0581
Trypanosoma cruzi target of rapamycin kinase 3 0.3779 0.7949 0.7937
Schistosoma mansoni voltage-gated potassium channel 0.0147 0.0247 0.0209
Entamoeba histolytica protein kinase rad3, putative 0.0898 0.1839 0.1839
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0057 0.0056 0.0051
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0122 0.0194 0.0155
Echinococcus multilocularis voltage gated potassium channel 0.0122 0.0194 0.0155
Loa Loa (eye worm) hypothetical protein 0.0122 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.0122 0.0194 0.0194
Trichomonas vaginalis PIKK family atypical protein kinase 0.353 0.7421 0.742
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0122 0.0194 0.0155
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0122 0.0194 0.0155
Schistosoma mansoni two-pore calcium channel 0.0122 0.0194 0.0155
Loa Loa (eye worm) phosphatidylinositol kinase 0.0306 0.0585 0.0585
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0306 0.0585 0.0548
Echinococcus granulosus transient receptor potential cation channel 0.0122 0.0194 0.0155
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0306 0.0585 0.0788
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0306 0.0585 0.0532
Brugia malayi Protein kinase domain containing protein 0.0033 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0122 0.0194 0.0194
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0306 0.0585 0.0585
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.4746 1 1
Loa Loa (eye worm) hypothetical protein 0.0122 0.0194 0.0194
Echinococcus multilocularis potassium voltage gated channel protein 0.0122 0.0194 0.0155
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.4746 1 1
Echinococcus granulosus potassium voltage gated channel protein 0.0122 0.0194 0.0155
Echinococcus granulosus voltage gated potassium channel 0.0147 0.0247 0.0209
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0122 0.0194 0.0155
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0122 0.0194 0.0155
Entamoeba histolytica protein kinase, putative 0.0033 0.0004 0.0004
Echinococcus multilocularis two pore calcium channel protein 1 0.0122 0.0194 0.0155
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0137 0.0225 0.0187
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0147 0.0247 0.0247
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0122 0.0194 0.0194
Schistosoma mansoni voltage-gated ion channel 0.0122 0.0194 0.0155
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.3779 0.7949 0.7937
Echinococcus granulosus voltage dependent calcium channel 0.0122 0.0194 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0898 0.1839 0.1835
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0306 0.0585 0.0548
Trichomonas vaginalis conserved hypothetical protein 0.0591 0.1189 0.1186
Echinococcus granulosus shaker cognate 0.0122 0.0194 0.0155
Echinococcus multilocularis fk506 binding protein 0.0057 0.0056 0.0017
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0122 0.0194 0.0139
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1592 0.331 0.3273
Leishmania major hypothetical protein, conserved 0.0306 0.0585 0.0532
Loa Loa (eye worm) hypothetical protein 0.0898 0.1839 0.1839
Leishmania major hypothetical protein, unknown function 0.0122 0.0194 0.0139
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.4746 1 1
Leishmania major hypothetical protein, unknown function 0.0306 0.0585 0.0532
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0306 0.0585 0.0532
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0122 0.0194 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.2559 0.5362 0.536
Trichomonas vaginalis PIKK family atypical protein kinase 0.2836 0.5949 0.5947
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0306 0.0585 0.0581
Echinococcus multilocularis calcium activated potassium channel 0.0122 0.0194 0.0156
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0306 0.0585 0.0788
Loa Loa (eye worm) hypothetical protein 0.0122 0.0194 0.0194
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0122 0.0194 0.0155
Schistosoma mansoni calcium-activated potassium channel 0.0122 0.0194 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.0694 0.1407 0.1403
Echinococcus granulosus potassium voltage gated channel protein 0.0122 0.0194 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0898 0.1839 0.1835
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0137 0.0225 0.0187
Echinococcus granulosus voltage gated hydrogen channel 1 0.0122 0.0194 0.0155
Loa Loa (eye worm) phosphatidylinositol 3 0.4746 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0898 0.1839 0.1793
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0122 0.0194 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.1592 0.331 0.3308
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0306 0.0585 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1592 0.331 0.3308
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1592 0.331 0.3284
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0137 0.0225 0.0187
Brugia malayi hypothetical protein 0.0122 0.0194 0.0194
Entamoeba histolytica hypothetical protein 0.0898 0.1839 0.1839
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0122 0.0194 0.0155
Mycobacterium leprae conserved hypothetical protein 0.0306 0.0585 0.5
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0227 0.0416 0.0416
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0306 0.0585 0.0581
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0122 0.0194 0.0261
Schistosoma mansoni 60S ribosomal protein L21 0.0132 0.0216 0.0177
Echinococcus multilocularis hyperpolarization activated cyclic 0.0137 0.0225 0.0187
Trichomonas vaginalis conserved hypothetical protein 0.1 0.2056 0.2053
Echinococcus granulosus two pore calcium channel protein 2 0.0122 0.0194 0.0155
Echinococcus multilocularis short transient receptor potential channel 6 0.0122 0.0194 0.0155
Loa Loa (eye worm) voltage-gated calcium channel 0.0122 0.0194 0.0194
Toxoplasma gondii transporter, cation channel family protein 0.0122 0.0194 0.0261
Echinococcus granulosus voltage gated potassium channel 0.0122 0.0194 0.0155
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0306 0.0585 0.0585
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0591 0.1189 0.114
Trichomonas vaginalis PIKK family atypical protein kinase 0.2836 0.5949 0.5947
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0122 0.0194 0.0155
Loa Loa (eye worm) hypothetical protein 0.0694 0.1407 0.1407
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0306 0.0585 0.0585
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0122 0.0194 0.0155
Echinococcus multilocularis short transient receptor potential channel 6 0.0122 0.0194 0.0155
Schistosoma mansoni voltage-gated potassium channel 0.0122 0.0194 0.0155
Schistosoma mansoni voltage-gated potassium channel 0.0137 0.0225 0.0187
Trichomonas vaginalis PIKK family atypical protein kinase 0.2808 0.589 0.5888
Leishmania major phosphatidylinositol kinase related protein, putative 0.0306 0.0585 0.0532
Entamoeba histolytica hypothetical protein 0.0306 0.0585 0.0585
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0137 0.0225 0.0225
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0306 0.0585 0.0581
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0306 0.0585 0.0585
Loa Loa (eye worm) hypothetical protein 0.0306 0.0585 0.0585
Trichomonas vaginalis PIKK family atypical protein kinase 0.2559 0.5362 0.536
Trichomonas vaginalis PIKK family atypical protein kinase 0.2563 0.537 0.5368
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0306 0.0585 0.0548
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0898 0.1839 0.1807
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.4746 1 1
Echinococcus multilocularis transient receptor potential gamma protein 0.0122 0.0194 0.0155
Toxoplasma gondii target of rapamycin (TOR), putative 0.353 0.7421 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0306 0.0585 0.0585
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0137 0.0225 0.0221
Echinococcus multilocularis transient receptor potential cation channel 0.0122 0.0194 0.0155
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0306 0.0585 1
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0137 0.0225 0.0187
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0306 0.0585 0.0585
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0057 0.0056 0.0017
Loa Loa (eye worm) hypothetical protein 0.0122 0.0194 0.0194
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0306 0.0585 0.0548
Loa Loa (eye worm) hypothetical protein 0.0122 0.0194 0.0194
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0122 0.0194 0.0155
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0306 0.0585 0.0548
Echinococcus granulosus transient receptor potential cation channel 0.0122 0.0194 0.0155
Loa Loa (eye worm) phosphatidylinositol 3 0.0306 0.0585 0.0585
Schistosoma mansoni hypothetical protein 0.0306 0.0585 0.0548
Echinococcus granulosus transient receptor potential cation channel 0.0122 0.0194 0.0155
Brugia malayi FAT domain containing protein 0.0694 0.1407 0.1407
Trichomonas vaginalis PIKK family atypical protein kinase 0.3775 0.7941 0.794
Echinococcus granulosus two pore calcium channel protein 1 0.0122 0.0194 0.0155
Echinococcus multilocularis conserved hypothetical protein 0.0122 0.0194 0.0155
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0898 0.1839 0.1839
Loa Loa (eye worm) hypothetical protein 0.0122 0.0194 0.0194
Trichomonas vaginalis immunophilin, putative 0.0057 0.0056 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.353 0.7421 0.742
Trichomonas vaginalis PIKK family atypical protein kinase 0.2563 0.537 0.5368
Entamoeba histolytica hypothetical protein 0.0306 0.0585 0.0585
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0306 0.0585 0.0532
Schistosoma mansoni transient receptor potential channel 0.0122 0.0194 0.0155
Echinococcus multilocularis voltage dependent calcium channel 0.0122 0.0194 0.0155
Leishmania major phosphatidylinositol kinase, putative 0.0306 0.0585 0.0532
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0306 0.0585 0.0585
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0306 0.0585 0.0548
Loa Loa (eye worm) phosphatidylinositol 3 0.1592 0.331 0.331
Schistosoma mansoni voltage-gated potassium channel 0.0122 0.0194 0.0155
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0306 0.0585 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.4746 1 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0306 0.0585 0.0532
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0306 0.0585 0.0548
Trichomonas vaginalis PIKK family atypical protein kinase 0.0306 0.0585 0.0581
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0137 0.0225 0.0187
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0122 0.0194 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.4052 0.8528 0.8528
Toxoplasma gondii hypothetical protein 0.0122 0.0194 0.0261
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0122 0.0194 0.0155
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0306 0.0585 0.0581
Schistosoma mansoni voltage-gated potassium channel 0.0122 0.0194 0.0155
Echinococcus granulosus hypothetical protein 0.0122 0.0194 0.0155
Schistosoma mansoni transient receptor potential channel 0.0122 0.0194 0.0155
Schistosoma mansoni voltage-gated potassium channel 0.0122 0.0194 0.0155
Echinococcus granulosus short transient receptor potential channel 6 0.0122 0.0194 0.0155
Brugia malayi olfactory channel protein osm-9 0.0122 0.0194 0.0194
Schistosoma mansoni voltage-gated potassium channel 0.0122 0.0194 0.0155
Loa Loa (eye worm) hypothetical protein 0.0122 0.0194 0.0194
Toxoplasma gondii FATC domain-containing protein 0.0898 0.1839 0.2478
Loa Loa (eye worm) hypothetical protein 0.0122 0.0194 0.0194
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0057 0.0056 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0591 0.1189 0.1186
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0306 0.0585 0.0585
Loa Loa (eye worm) hypothetical protein 0.0967 0.1986 0.1986
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0122 0.0194 0.0194
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0306 0.0585 0.0548
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0122 0.0194 0.0155
Schistosoma mansoni voltage-gated potassium channel 0.0237 0.0438 0.0401
Schistosoma mansoni hypothetical protein 0.0122 0.0194 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.2808 0.589 0.5888
Echinococcus granulosus transient receptor potential gamma protein 0.0122 0.0194 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.1273 0.2636 0.2632
Echinococcus multilocularis potassium voltage gated channel protein 0.0122 0.0194 0.0155
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0122 0.0194 0.0139
Loa Loa (eye worm) hypothetical protein 0.0122 0.0194 0.0194
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0147 0.0247 0.0209

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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