Detailed information for compound 1638480

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 7871.03 | Formula: C264H376N78O123P20S20
  • H donors: 57 H acceptors: 66 LogP: -8.1 Rotable bonds: 182
    Rule of 5 violations (Lipinski): 4
  • SMILES: CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N)CSC1CC(=O)N(C1=O)CCCCCC(=O)NCCCCCCOP(=O)(OC[C@H]1O[C@H](C[C@@H]1OP(=S)(OC[C@H]1O[C@H](C[C@@H]1OP(=S)(OC[C@H]1O[C@H](C[C@@H]1OP(=S)(OC[C@H]1O[C@H](C[C@@H]1OP(=S)(OC[C@H]1O[C@H](C[C@@H]1OP(=S)(OC[C@H]1O[C@H](C[C@@H]1OP(=S)(OC[C@H]1O[C@H](C[C@@H]1OP(=S)(OC[C@H]1O[C@H](C[C@@H]1OP(=S)(OC[C@H]1O[C@H](C[C@@H]1OP(=S)(OC[C@H]1O[C@H](C[C@@H]1OP(=S)(OC[C@H]1O[C@H](C[C@@H]1OP(=S)(OC[C@H]1O[C@H](C[C@@H]1OP(=S)(OC[C@H]1O[C@H](C[C@@H]1OP(=S)(OC[C@H]1O[C@H](C[C@@H]1OP(=S)(OC[C@H]1O[C@H](C[C@@H]1OP(=S)(OC[C@H]1O[C@H](C[C@@H]1OP(=S)(OC[C@H]1O[C@H](C[C@@H]1OP(=S)(OC[C@H]1O[C@H](C[C@@H]1OP(=S)(OC[C@H]1O[C@H](C[C@@H]1OP(=S)(OC[C@H]1O[C@H](C[C@@H]1O)n1ccc(nc1=O)N)O)n1ccc(nc1=O)N)O)n1cc(C)c(=O)[nH]c1=O)O)n1ccc(nc1=O)N)O)n1cnc2c1nc(N)[nH]c2=O)O)n1cnc2c1nc(N)[nH]c2=O)O)n1cc(C)c(=O)[nH]c1=O)O)n1ccc(nc1=O)N)O)n1ccc(nc1=O)N)O)n1ccc(nc1=O)N)O)n1ccc(nc1=O)N)O)n1ccc(nc1=O)N)O)n1ccc(nc1=O)N)O)n1cc(C)c(=O)[nH]c1=O)O)n1ccc(nc1=O)N)O)n1cnc2c1nc(N)[nH]c2=O)O)n1cc(C)c(=O)[nH]c1=O)O)n1ccc(nc1=O)N)O)n1ccc(nc1=O)N)O)n1ccc(nc1=O)N)O)NC(=O)[C@@H]1CCCN1C(=O)C(NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)C(NC(=O)[C@H]([C@H](CC)C)NC(=O)[C@H]([C@H](CC)C)NC(=O)[C@@H](NC(=O)C(NC(=O)C)(C)C)CC(=O)N)(C)C)CC(C)C)CC(C)C)(C)C)C
  • InChi: 1S/C264H376N78O123P20S20/c1-22-122(8)213(305-231(357)135-35-33-53-321(135)240(366)263(18,19)318-229(355)131(69-121(6)7)287-227(353)130(68-120(4)5)288-230(356)134-34-32-52-320(134)241(367)264(20,21)319-237(363)215(124(10)24-3)306-233(359)214(123(9)23-2)304-228(354)132(70-190(278)345)290-239(365)262(16,17)317-129(15)343)232(358)289-133(219(279)348)116-505-176-91-192(347)322(238(176)364)51-30-27-28-36-191(346)283-50-29-25-26-31-67-406-466(385,386)407-97-157-137(72-194(428-157)324-55-38-178(266)292-246(324)369)447-468(388,487)409-99-159-139(74-196(430-159)326-57-40-180(268)294-248(326)371)449-469(389,488)414-104-164-145(80-202(435-164)332-63-46-186(274)300-254(332)377)455-475(395,494)422-111-171-151(86-208(442-171)338-94-127(13)225(351)315-260(338)383)461-481(401,500)424-113-173-153(88-210(444-173)340-117-284-216-220(340)307-242(280)310-234(216)360)463-483(403,502)418-107-167-147(82-204(438-167)334-65-48-188(276)302-256(334)379)457-478(398,497)421-110-170-150(85-207(441-170)337-93-126(12)224(350)314-259(337)382)460-480(400,499)417-106-166-144(79-201(437-166)331-62-45-185(273)299-253(331)376)454-474(394,493)413-103-163-142(77-199(434-163)329-60-43-183(271)297-251(329)374)452-472(392,491)411-101-161-140(75-197(432-161)327-58-41-181(269)295-249(327)372)450-470(390,489)410-100-160-141(76-198(431-160)328-59-42-182(270)296-250(328)373)451-471(391,490)412-102-162-143(78-200(433-162)330-61-44-184(272)298-252(330)375)453-473(393,492)415-105-165-146(81-203(436-165)333-64-47-187(275)301-255(333)378)456-476(396,495)423-112-172-152(87-209(443-172)339-95-128(14)226(352)316-261(339)384)462-482(402,501)425-114-174-155(90-212(445-174)342-119-286-218-222(342)309-244(282)312-236(218)362)465-485(405,504)426-115-175-154(89-211(446-175)341-118-285-217-221(341)308-243(281)311-235(217)361)464-484(404,503)419-108-168-148(83-205(439-168)335-66-49-189(277)303-257(335)380)458-477(397,496)420-109-169-149(84-206(440-169)336-92-125(11)223(349)313-258(336)381)459-479(399,498)416-98-158-138(73-195(429-158)325-56-39-179(267)293-247(325)370)448-467(387,486)408-96-156-136(344)71-193(427-156)323-54-37-177(265)291-245(323)368/h37-49,54-66,92-95,117-124,130-176,193-215,344H,22-36,50-53,67-91,96-116H2,1-21H3,(H2,278,345)(H2,279,348)(H,283,346)(H,287,353)(H,288,356)(H,289,358)(H,290,365)(H,304,354)(H,305,357)(H,306,359)(H,317,343)(H,318,355)(H,319,363)(H,385,386)(H,387,486)(H,388,487)(H,389,488)(H,390,489)(H,391,490)(H,392,491)(H,393,492)(H,394,493)(H,395,494)(H,396,495)(H,397,496)(H,398,497)(H,399,498)(H,400,499)(H,401,500)(H,402,501)(H,403,502)(H,404,503)(H,405,504)(H2,265,291,368)(H2,266,292,369)(H2,267,293,370)(H2,268,294,371)(H2,269,295,372)(H2,270,296,373)(H2,271,297,374)(H2,272,298,375)(H2,273,299,376)(H2,274,300,377)(H2,275,301,378)(H2,276,302,379)(H2,277,303,380)(H,313,349,381)(H,314,350,382)(H,315,351,383)(H,316,352,384)(H3,280,307,310,360)(H3,281,308,311,361)(H3,282,309,312,362)/t122-,123-,124-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,152-,153-,154-,155-,156+,157+,158+,159+,160+,161+,162+,163+,164+,165+,166+,167+,168+,169+,170+,171+,172+,173+,174+,175+,176?,193+,194+,195+,196+,197+,198+,199+,200+,201+,202+,203+,204+,205+,206+,207+,208+,209+,210+,211+,212+,213-,214-,215-,467?,468?,469?,470?,471?,472?,473?,474?,475?,476?,477?,478?,479?,480?,481?,482?,483?,484?,485?/m0/s1
  • InChiKey: WZUDOUFCWWUEPP-ZIYJDXEPSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis 0.0342 0.0609 0.0609
Trichomonas vaginalis PIKK family atypical protein kinase 0.2865 0.5382 0.538
Trichomonas vaginalis PIKK family atypical protein kinase 0.3946 0.7428 0.7427
Trichomonas vaginalis PIKK family atypical protein kinase 0.1003 0.186 0.1857
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0342 0.0609 0.0795
Trichomonas vaginalis PIKK family atypical protein kinase 0.422 0.7946 0.7945
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0776 0.1429 0.1429
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0342 0.0609 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0058 0.007 0.007
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0342 0.0609 0.0609
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0342 0.0609 0.0606
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0342 0.0609 0.0606
Trichomonas vaginalis PIKK family atypical protein kinase 0.4529 0.8532 0.8532
Trichomonas vaginalis PIKK family atypical protein kinase 0.1779 0.3328 0.3326
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0342 0.0609 0.0606
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0342 0.0609 0.0606
Trichomonas vaginalis PIKK family atypical protein kinase 0.5305 1 1
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0342 0.0609 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.0609 0.0606
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0342 0.0609 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0022 0.0004 0.0004
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0022 0.0004 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.1003 0.186 0.1857
Loa Loa (eye worm) phosphatidylinositol 3 0.0342 0.0609 0.0606
Trypanosoma cruzi Protein kinase B 0.0023 0.0004 0.0004
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0058 0.007 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.3139 0.59 0.5899
Trichomonas vaginalis PIKK family atypical protein kinase 0.1423 0.2655 0.2652
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0022 0.0004 0.0004
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0342 0.0609 0.0606
Schistosoma mansoni voltage-gated potassium channel 0.0122 0.0193 0.019
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0022 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0661 0.1212 0.1209
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.005 0.0055 0.0055
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0342 0.0609 0.0606
Loa Loa (eye worm) hypothetical protein 0.1081 0.2007 0.2004
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1003 0.186 0.1857
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1779 0.3328 0.3328
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0342 0.0609 0.0609
Trichomonas vaginalis fk506-binding protein, putative 0.0058 0.007 0.0067
Loa Loa (eye worm) hypothetical protein 0.1003 0.186 0.1857
Loa Loa (eye worm) phosphatidylinositol 3 0.5305 1 1
Loa Loa (eye worm) hypothetical protein 0.0776 0.1429 0.1426
Echinococcus multilocularis hyperpolarization activated cyclic 0.0022 0.0004 0.0004
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0342 0.0609 0.0587
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1118 0.2077 0.2777
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0023 0.0019
Echinococcus multilocularis Zinc finger, PHD finger 0.0342 0.0609 0.0609
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0112 0.0174 0.0174
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0342 0.0609 0.0606
Loa Loa (eye worm) hypothetical protein 0.005 0.0055 0.0052
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0058 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0032 0.0023 0.0019
Entamoeba histolytica protein kinase, putative 0.0033 0.0024 0.0023
Entamoeba histolytica hypothetical protein 0.1003 0.186 0.186
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1779 0.3328 0.3312
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0058 0.007 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.1779 0.3328 0.3326
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0342 0.0609 0.0606
Entamoeba histolytica hypothetical protein 0.0342 0.0609 0.0609
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0058 0.007 0.0067
Trichomonas vaginalis PIKK family atypical protein kinase 0.286 0.5374 0.5372
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0342 0.0609 0.0609
Leishmania major phosphatidylinositol 4-kinase, putative 0.0342 0.0609 0.0543
Trichomonas vaginalis PIKK family atypical protein kinase 0.3139 0.59 0.5899
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0058 0.007 0.5
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0342 0.0609 0.0606
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0342 0.0609 0.0609
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0342 0.0609 0.0606
Loa Loa (eye worm) hypothetical protein 0.0661 0.1212 0.1209
Trichomonas vaginalis PIKK family atypical protein kinase 0.317 0.596 0.5958
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0776 0.1429 0.1429
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0032 0.0023 0.0023
Trichomonas vaginalis immunophilin, putative 0.0058 0.007 0.0067
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0342 0.0609 0.0609
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0342 0.0609 0.0606
Giardia lamblia Hypothetical protein 0.0342 0.0609 0.0609
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.005 0.0055 0.0055
Leishmania major phosphatidylinositol 3-kinase, putative 0.0342 0.0609 0.0543
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0342 0.0609 0.0795
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0058 0.007 0.007
Toxoplasma gondii target of rapamycin (TOR), putative 0.3946 0.7428 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.5305 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2865 0.5382 0.538
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0342 0.0609 0.0606
Echinococcus granulosus serine protein kinase ATM 0.1003 0.186 0.186
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0342 0.0609 0.0609
Trichomonas vaginalis PIKK family atypical protein kinase 0.3946 0.7428 0.7427
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0024 0.002
Echinococcus multilocularis voltage gated potassium channel 0.0032 0.0023 0.0023
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1003 0.186 0.186
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0342 0.0609 0.0609
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0058 0.007 0.007
Trypanosoma cruzi target of rapamycin kinase 3 0.4224 0.7954 0.7954
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0058 0.007 0.0067
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.5305 1 1
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0022 0.0004 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.5305 1 1
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0342 0.0609 0.0606
Loa Loa (eye worm) hypothetical protein 0.0342 0.0609 0.0606
Giardia lamblia Phosphatidylinositol 4-kinase 0.0342 0.0609 0.0609
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0024 0.002
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0342 0.0609 0.0587
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0342 0.0609 0.0587
Trichomonas vaginalis PIKK family atypical protein kinase 0.0661 0.1212 0.1209
Trichomonas vaginalis PIKK family atypical protein kinase 0.1003 0.186 0.1857
Trypanosoma brucei target of rapamycin kinase 3, putative 0.4224 0.7954 0.7949
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0058 0.007 0.007
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0058 0.007 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.286 0.5374 0.5372
Trichomonas vaginalis PIKK family atypical protein kinase 0.317 0.596 0.5958
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0342 0.0609 0.0606
Schistosoma mansoni fkbp-rapamycin associated protein 0.1003 0.186 0.1857
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0342 0.0609 0.0606
Loa Loa (eye worm) phosphatidylinositol 3 0.1779 0.3328 0.3326
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0342 0.0609 0.0606
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.5305 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.0609 0.0606
Loa Loa (eye worm) phosphatidylinositol 3 0.0342 0.0609 0.0606
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0058 0.007 0.007
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1779 0.3328 0.3312
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.5305 1 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0661 0.1212 0.1212
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0342 0.0609 0.0606
Schistosoma mansoni immunophilin 0.0058 0.007 0.0067
Loa Loa (eye worm) AGC/AKT protein kinase 0.0033 0.0024 0.002
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1779 0.3328 0.3328
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0342 0.0609 0.0606
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2203 0.4131 0.4117
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0342 0.0609 0.0543
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0342 0.0609 0.0795
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0031 0.002 0.0017
Echinococcus granulosus hyperpolarization activated cyclic 0.0022 0.0004 0.0004
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.5305 1 1
Onchocerca volvulus 0.0342 0.0609 0.5
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0342 0.0609 0.0609
Entamoeba histolytica protein kinase rad3, putative 0.1003 0.186 0.186
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0342 0.0609 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0342 0.0609 0.0609
Leishmania major phosphatidylinositol 3-kinase, putative 0.1779 0.3328 0.3281
Mycobacterium leprae conserved hypothetical protein 0.0342 0.0609 0.5
Echinococcus granulosus serine/threonine protein kinase 0.0023 0.0004 0.0004
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0022 0.0004 0.0004
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0342 0.0609 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.5305 1 1
Entamoeba histolytica hypothetical protein 0.0342 0.0609 0.0609
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0342 0.0609 0.0609
Schistosoma mansoni voltage-gated potassium channel 0.0122 0.0193 0.019
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0058 0.007 0.007
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0022 0.0004 0.0004
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0342 0.0609 0.0795
Entamoeba histolytica PH domain containing protein kinase, putative 0.0023 0.0004 0.0004
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0105 0.016 0.0156
Loa Loa (eye worm) hypothetical protein 0.0342 0.0609 0.0606
Trichomonas vaginalis PIKK family atypical protein kinase 0.5305 1 1
Schistosoma mansoni hypothetical protein 0.0342 0.0609 0.0606
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0342 0.0609 0.0606
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0342 0.0609 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1003 0.186 0.186
Leishmania major phosphatidylinositol kinase, putative 0.0342 0.0609 0.0543
Trichomonas vaginalis PIKK family atypical protein kinase 0.2865 0.5382 0.538
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0342 0.0609 0.0609
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1003 0.186 0.186
Echinococcus multilocularis hyperpolarization activated cyclic 0.0022 0.0004 0.0004
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0342 0.0609 0.0609
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1779 0.3328 0.3328
Echinococcus granulosus voltage gated potassium channel 0.0032 0.0023 0.0023
Echinococcus multilocularis rac serine:threonine kinase 0.0023 0.0004 0.0004
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0024 0.002
Mycobacterium tuberculosis Conserved hypothetical protein 0.0342 0.0609 0.5
Echinococcus multilocularis fk506 binding protein 0.0058 0.007 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.422 0.7946 0.7945
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2509 0.4709 0.4696
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0342 0.0609 0.0609
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.5305 1 1
Brugia malayi p70 ribosomal S6 kinase beta 0.0031 0.002 0.0017
Schistosoma mansoni immunophilin 0.0058 0.007 0.0067
Trichomonas vaginalis PIKK family atypical protein kinase 0.1779 0.3328 0.3326
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0342 0.0609 0.0606
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0024 0.002
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.5305 1 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0342 0.0609 0.0609
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0342 0.0609 0.0795
Entamoeba histolytica protein kinase, putative 0.0031 0.002 0.002
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1779 0.3328 0.3326
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0112 0.0174 0.017
Plasmodium vivax hypothetical protein 0.0342 0.0609 1
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0058 0.007 0.0067
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0342 0.0609 0.0606
Trichomonas vaginalis PIKK family atypical protein kinase 0.3444 0.6478 0.6477
Plasmodium vivax hypothetical protein, conserved 0.0342 0.0609 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.422 0.7946 0.7945
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1779 0.3328 0.3328
Trichomonas vaginalis PIKK family atypical protein kinase 0.1779 0.3328 0.3326
Schistosoma mansoni serine/threonine-protein kinase 0.0023 0.0004 0.0001
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0024 0.002
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0342 0.0609 0.0609
Trichomonas vaginalis PIKK family atypical protein kinase 0.1779 0.3328 0.3326
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0342 0.0609 0.0606
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0058 0.007 0.115
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0058 0.007 0.007
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0342 0.0609 0.0609
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.5305 1 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0032 0.0023 0.0023
Onchocerca volvulus 0.0342 0.0609 0.5
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.5305 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0342 0.0609 0.0606
Loa Loa (eye worm) phosphatidylinositol kinase 0.0342 0.0609 0.0606
Trichomonas vaginalis PIKK family atypical protein kinase 0.317 0.596 0.5958
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1779 0.3328 0.3326
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0112 0.0174 0.0174
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0112 0.0174 0.017
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0342 0.0609 0.0606
Schistosoma mansoni serine/threonine-protein kinase 0.0023 0.0004 0.0001
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.4224 0.7954 0.794
Brugia malayi Protein kinase domain containing protein 0.0033 0.0024 0.002
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0342 0.0609 0.0609
Trichomonas vaginalis PIKK family atypical protein kinase 0.422 0.7946 0.7945
Leishmania major hypothetical protein, conserved 0.0342 0.0609 0.0543
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1003 0.186 0.186
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0342 0.0609 1
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1003 0.186 0.1841
Loa Loa (eye worm) FKBP5 protein 0.0058 0.007 0.0067
Entamoeba histolytica hypothetical protein 0.0342 0.0609 0.0609
Loa Loa (eye worm) phosphatidylinositol 3 0.0342 0.0609 0.0606
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0342 0.0609 0.0609
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0032 0.0023 0.0019
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0342 0.0609 0.0609
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0105 0.016 0.0156
Trichomonas vaginalis PIKK family atypical protein kinase 0.3946 0.7428 0.7427
Trichomonas vaginalis PIKK family atypical protein kinase 0.3559 0.6695 0.6694
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0342 0.0609 0.0609
Brugia malayi FAT domain containing protein 0.0776 0.1429 0.1426
Echinococcus multilocularis serine protein kinase ATM 0.1003 0.186 0.186
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0342 0.0609 0.0609
Leishmania major hypothetical protein, unknown function 0.0342 0.0609 0.0543
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0342 0.0609 0.0609
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0342 0.0609 0.0609
Schistosoma mansoni hypothetical protein 0.0776 0.1429 0.1426
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0023 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.1118 0.2077 0.2074
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.5305 1 1
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0058 0.007 0.0067
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0342 0.0609 0.0609
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0058 0.007 0.0047
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0342 0.0609 0.0609
Entamoeba histolytica protein kinase, putative 0.0033 0.0024 0.0023
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0024 0.002
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0342 0.0609 0.0609
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0342 0.0609 0.0609
Loa Loa (eye worm) hypothetical protein 0.1118 0.2077 0.2074
Giardia lamblia GTOR 0.5305 1 1
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0058 0.007 0.115
Trichomonas vaginalis PIKK family atypical protein kinase 0.3946 0.7428 0.7427
Leishmania major phosphatidylinositol kinase related protein, putative 0.0342 0.0609 0.0543
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0023 0.0019
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0342 0.0609 0.0609
Trichomonas vaginalis PIKK family atypical protein kinase 0.3946 0.7428 0.7427
Trichomonas vaginalis PIKK family atypical protein kinase 0.3946 0.7428 0.7427
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0342 0.0609 0.0606
Loa Loa (eye worm) phosphatidylinositol 3 0.0342 0.0609 0.0606
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0342 0.0609 0.0606
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0342 0.0609 0.0609
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0342 0.0609 0.0606
Schistosoma mansoni immunophilin 0.005 0.0055 0.0052
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0058 0.007 0.0067
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0022 0.0004 0.0004
Entamoeba histolytica PH domain containing protein kinase, putative 0.0023 0.0004 0.0004
Toxoplasma gondii FATC domain-containing protein 0.1003 0.186 0.2484
Trichomonas vaginalis conserved hypothetical protein 0.0776 0.1429 0.1426
Entamoeba histolytica hypothetical protein 0.0342 0.0609 0.0609
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0058 0.007 0.007
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0024 0.002
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0342 0.0609 0.0606
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1003 0.186 0.1857
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1779 0.3328 0.3281
Loa Loa (eye worm) hypothetical protein 0.0097 0.0146 0.0142
Trichomonas vaginalis PIKK family atypical protein kinase 0.422 0.7946 0.7945
Trichomonas vaginalis PIKK family atypical protein kinase 0.2865 0.5382 0.538
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0342 0.0609 0.0609
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0342 0.0609 0.0609
Trichomonas vaginalis PIKK family atypical protein kinase 0.286 0.5374 0.5372
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0342 0.0609 0.0587
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0342 0.0609 0.0606
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0058 0.007 0.007
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0342 0.0609 0.0609
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0058 0.007 0.0067
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1003 0.186 0.1857
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0342 0.0609 0.0609
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0342 0.0609 0.0609
Trichomonas vaginalis PIKK family atypical protein kinase 0.3946 0.7428 0.7427
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1003 0.186 0.186

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 50 % Antisense activity in human A549 cells assessed as down regulation of p53 protein at 5 uM incubated for 8 hrs in serum-free medium followed by 24 hrs incubation in serum-containing medium by Western blotting analysis ChEMBL. 22525495

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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