Detailed information for compound 1638481

Basic information

Technical information
  • TDR Targets ID: 1638481
  • Name: 3-(4-bromophenyl)-1-(4-methoxyphenyl)prop-2-e n-1-one
  • MW: 317.177 | Formula: C16H13BrO2
  • H donors: 0 H acceptors: 1 LogP: 4.35 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C(=O)/C=C/c1ccc(cc1)Br
  • InChi: 1S/C16H13BrO2/c1-19-15-9-5-13(6-10-15)16(18)11-4-12-2-7-14(17)8-3-12/h2-11H,1H3/b11-4+
  • InChiKey: DDKSEIMPHBCIKS-NYYWCZLTSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-3-(4-bromophenyl)-1-(4-methoxyphenyl)prop-2-en-1-one
  • (2E)-3-(4-Bromophenyl)-1-(4-methoxyphenyl)-2-propen-1-one
  • trans-4-Bromo-4'-methoxychalcone
  • ZINC04070316

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0292 0.0604 0.0604
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0292 0.0604 0.0599
Trichomonas vaginalis PIKK family atypical protein kinase 0.3035 0.6693 0.6692
Trichomonas vaginalis PIKK family atypical protein kinase 0.3365 0.7426 0.7425
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0104 0.0187 0.0182
Brugia malayi FAT domain containing protein 0.0661 0.1424 0.142
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0292 0.0604 0.0603
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0292 0.0604 0.0525
Giardia lamblia Hypothetical protein 0.0292 0.0604 0.0603
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0856 0.1855 0.1852
Trichomonas vaginalis conserved hypothetical protein 0.0953 0.2072 0.2069
Echinococcus granulosus hyperpolarization activated cyclic 0.0022 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0661 0.1424 0.142
Leishmania major phosphatidylinositol kinase related protein, putative 0.0292 0.0604 0.0525
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.4524 1 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0057 0.0083 0.0082
Entamoeba histolytica hypothetical protein 0.0292 0.0604 0.0603
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0057 0.0083 0.0078
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0292 0.0604 0.0603
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0292 0.0604 0.0604
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0292 0.0604 0.0599
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0028 0.0023
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0027 0.0023
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.4524 1 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0953 0.2072 0.2768
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0057 0.0083 0.0083
Leishmania major hypothetical protein, conserved 0.0292 0.0604 0.0525
Trichomonas vaginalis PIKK family atypical protein kinase 0.3365 0.7426 0.7425
Trichomonas vaginalis PIKK family atypical protein kinase 0.3365 0.7426 0.7425
Brugia malayi Protein kinase domain containing protein 0.0032 0.0028 0.0023
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0292 0.0604 0.0603
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0292 0.0604 0.0599
Trichomonas vaginalis PIKK family atypical protein kinase 0.3365 0.7426 0.7425
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0292 0.0604 0.0603
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0292 0.0604 0.0599
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0292 0.0604 0.0604
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0049 0.0065 0.0065
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0292 0.0604 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0022 0.0005 0.0005
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0022 0.0005 0.0005
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0057 0.0083 0.0082
Trichomonas vaginalis conserved hypothetical protein 0.0661 0.1424 0.142
Entamoeba histolytica hypothetical protein 0.0856 0.1855 0.1855
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0057 0.0083 0.5
Giardia lamblia Phosphatidylinositol 4-kinase 0.0292 0.0604 0.0603
Echinococcus multilocularis voltage gated potassium channel 0.0032 0.0027 0.0027
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0292 0.0604 0.0599
Leishmania major phosphatidylinositol 3-kinase, putative 0.1517 0.3324 0.3268
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0856 0.1855 0.1855
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0292 0.0604 0.0603
Trichomonas vaginalis PIKK family atypical protein kinase 0.3598 0.7945 0.7944
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0292 0.0604 0.0603
Trichomonas vaginalis PIKK family atypical protein kinase 0.2443 0.5379 0.5377
Loa Loa (eye worm) hypothetical protein 0.0097 0.017 0.0166
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0292 0.0604 0.0578
Trichomonas vaginalis PIKK family atypical protein kinase 0.2439 0.5371 0.5369
Loa Loa (eye worm) FKBP5 protein 0.0057 0.0083 0.0078
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0292 0.0604 0.0604
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0057 0.0083 0.0078
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0292 0.0604 0.0599
Echinococcus multilocularis serine protein kinase ATM 0.0856 0.1855 0.1855
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0292 0.0604 0.0599
Loa Loa (eye worm) phosphatidylinositol 3 0.0292 0.0604 0.0599
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0856 0.1855 0.1833
Trichomonas vaginalis PIKK family atypical protein kinase 0.3365 0.7426 0.7425
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.4524 1 1
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0292 0.0604 0.0599
Loa Loa (eye worm) phosphatidylinositol kinase 0.0292 0.0604 0.0599
Loa Loa (eye worm) phosphatidylinositol 3 0.0292 0.0604 0.0599
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0292 0.0604 1
Entamoeba histolytica protein kinase rad3, putative 0.0856 0.1855 0.1855
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0292 0.0604 0.0599
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0292 0.0604 0.0599
Trichomonas vaginalis PIKK family atypical protein kinase 0.2443 0.5379 0.5377
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0028 0.0023
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1517 0.3324 0.3324
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0292 0.0604 0.0603
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0022 0.0005 0.0004
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0856 0.1855 0.1855
Echinococcus multilocularis rac serine:threonine kinase 0.0022 0.0005 0.0005
Schistosoma mansoni immunophilin 0.0057 0.0083 0.0078
Mycobacterium tuberculosis Conserved hypothetical protein 0.0292 0.0604 0.5
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0028 0.0023
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2139 0.4706 0.4691
Trichomonas vaginalis PIKK family atypical protein kinase 0.0292 0.0604 0.0599
Trichomonas vaginalis PIKK family atypical protein kinase 0.3598 0.7945 0.7944
Brugia malayi p70 ribosomal S6 kinase beta 0.003 0.0023 0.0018
Loa Loa (eye worm) phosphatidylinositol 3 0.4524 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1517 0.3324 0.3321
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0292 0.0604 0.0599
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0057 0.0083 0.0078
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.4524 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0027 0.0023
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0292 0.0604 0.0784
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0292 0.0604 0.0604
Trichomonas vaginalis PIKK family atypical protein kinase 0.1517 0.3324 0.3321
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.003 0.0023 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.2937 0.6476 0.6475
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0292 0.0604 1
Schistosoma mansoni immunophilin 0.0057 0.0083 0.0078
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0111 0.0203 0.0199
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0292 0.0604 0.0599
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1517 0.3324 0.3306
Trichomonas vaginalis PIKK family atypical protein kinase 0.3598 0.7945 0.7944
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0292 0.0604 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0022 0.0005 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.1517 0.3324 0.3321
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0057 0.0083 0.0083
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0292 0.0604 0.0604
Trichomonas vaginalis PIKK family atypical protein kinase 0.1517 0.3324 0.3321
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0292 0.0604 0.0603
Entamoeba histolytica protein kinase, putative 0.0032 0.0028 0.0027
Echinococcus granulosus voltage gated potassium channel 0.0032 0.0027 0.0027
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.4524 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0292 0.0604 0.0603
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0057 0.0083 0.0083
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0292 0.0604 0.0603
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0292 0.0604 0.0604
Loa Loa (eye worm) hypothetical protein 0.0292 0.0604 0.0599
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.4524 1 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0111 0.0203 0.0203
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1517 0.3324 0.3321
Trichomonas vaginalis PIKK family atypical protein kinase 0.2703 0.5957 0.5956
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0022 0.0005 0.0005
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0292 0.0604 0.0604
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0111 0.0203 0.0203
Trypanosoma cruzi target of rapamycin kinase 3 0.3602 0.7953 0.7953
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0292 0.0604 0.0599
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0028 0.0023
Loa Loa (eye worm) hypothetical protein 0.0856 0.1855 0.1852
Leishmania major phosphatidylinositol 3-kinase, putative 0.0292 0.0604 0.0525
Trichomonas vaginalis PIKK family atypical protein kinase 0.3598 0.7945 0.7944
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0856 0.1855 0.1852
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0292 0.0604 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0292 0.0604 0.0599
Loa Loa (eye worm) hypothetical protein 0.0292 0.0604 0.0599
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0057 0.0083 0.0078
Loa Loa (eye worm) AGC/AKT protein kinase 0.0032 0.0028 0.0023
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0292 0.0604 0.0604
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0292 0.0604 0.0604
Trichomonas vaginalis PIKK family atypical protein kinase 0.3365 0.7426 0.7425
Toxoplasma gondii FATC domain-containing protein 0.0856 0.1855 0.2475
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0028 0.0023
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0032 0.0027 0.0027
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.3602 0.7953 0.7936
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0057 0.0083 0.0055
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0292 0.0604 0.0603
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.4524 1 1
Echinococcus multilocularis fk506 binding protein 0.0057 0.0083 0.0083
Giardia lamblia GTOR 0.4524 1 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0022 0.0005 0.0004
Entamoeba histolytica protein kinase, putative 0.0032 0.0028 0.0027
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0292 0.0604 0.0578
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0292 0.0604 0.0603
Loa Loa (eye worm) phosphatidylinositol 3 0.0292 0.0604 0.0599
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0292 0.0604 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0856 0.1855 0.1852
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0292 0.0604 0.0578
Trichomonas vaginalis PIKK family atypical protein kinase 0.0564 0.1207 0.1203
Trypanosoma brucei target of rapamycin kinase 3, putative 0.3602 0.7953 0.7947
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0057 0.0083 0.0055
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0057 0.0083 0.0078
Schistosoma mansoni hypothetical protein 0.0292 0.0604 0.0599
Trichomonas vaginalis PIKK family atypical protein kinase 0.2703 0.5957 0.5956
Trichomonas vaginalis PIKK family atypical protein kinase 0.2439 0.5371 0.5369
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0292 0.0604 0.0599
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.4524 1 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0292 0.0604 0.0603
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1517 0.3324 0.3324
Onchocerca volvulus 0.0292 0.0604 0.5
Schistosoma mansoni fkbp-rapamycin associated protein 0.0856 0.1855 0.1852
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.4524 1 1
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0057 0.0083 0.1362
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1517 0.3324 0.3306
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0292 0.0604 0.0599
Trichomonas vaginalis conserved hypothetical protein 0.0564 0.1207 0.1203
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0057 0.0083 0.0078
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0292 0.0604 0.0599
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0292 0.0604 0.0784
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1517 0.3324 0.3268
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0028 0.0023
Leishmania major phosphatidylinositol kinase, putative 0.0292 0.0604 0.0525
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1879 0.4128 0.4111
Echinococcus granulosus serine/threonine protein kinase 0.0022 0.0005 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.4524 1 1
Entamoeba histolytica protein kinase, putative 0.003 0.0023 0.0023
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0292 0.0604 0.0599
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0292 0.0604 0.0604
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0292 0.0604 1
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0292 0.0604 0.0604
Trichomonas vaginalis PIKK family atypical protein kinase 0.0856 0.1855 0.1852
Loa Loa (eye worm) phosphatidylinositol 3 0.1517 0.3324 0.3321
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0292 0.0604 0.0603
Echinococcus granulosus hyperpolarization activated cyclic 0.0022 0.0005 0.0005
Loa Loa (eye worm) phosphatidylinositol 3 0.0292 0.0604 0.0599
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.4524 1 1
Plasmodium vivax hypothetical protein 0.0292 0.0604 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0022 0.0005 0.0004
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0057 0.0083 0.0082
Schistosoma mansoni voltage-gated potassium channel 0.0122 0.0226 0.0221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0292 0.0604 0.0599
Entamoeba histolytica hypothetical protein 0.0292 0.0604 0.0603
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0104 0.0187 0.0182
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0292 0.0604 0.0784
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0022 0.0005 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.3365 0.7426 0.7425
Echinococcus multilocularis 0.0292 0.0604 0.0604
Trichomonas vaginalis PIKK family atypical protein kinase 0.2443 0.5379 0.5377
Trichomonas vaginalis PIKK family atypical protein kinase 0.0856 0.1855 0.1852
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0292 0.0604 0.0603
Trichomonas vaginalis PIKK family atypical protein kinase 0.3598 0.7945 0.7944
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0292 0.0604 0.0784
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0661 0.1424 0.1424
Trichomonas vaginalis PIKK family atypical protein kinase 0.3862 0.8531 0.8531
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0292 0.0604 0.0599
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0292 0.0604 0.0599
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0292 0.0604 0.0603
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0057 0.0083 0.0082
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0292 0.0604 0.0599
Trichomonas vaginalis PIKK family atypical protein kinase 0.4524 1 1
Echinococcus multilocularis Zinc finger, PHD finger 0.0292 0.0604 0.0604
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1517 0.3324 0.3324
Entamoeba histolytica hypothetical protein 0.0292 0.0604 0.0603
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0292 0.0604 0.0599
Plasmodium vivax hypothetical protein, conserved 0.0292 0.0604 1
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0856 0.1855 0.1855
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0022 0.0005 0.0005
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0022 0.0005 0.0005
Loa Loa (eye worm) phosphatidylinositol 3 0.0292 0.0604 0.0599
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0057 0.0083 0.1362
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0022 0.0005 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.1214 0.2651 0.2647
Trichomonas vaginalis PIKK family atypical protein kinase 0.2676 0.5898 0.5896
Trypanosoma cruzi Protein kinase B 0.0022 0.0005 0.0004
Schistosoma mansoni voltage-gated potassium channel 0.0122 0.0226 0.0221
Onchocerca volvulus 0.0292 0.0604 0.5
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0292 0.0604 0.0603
Loa Loa (eye worm) hypothetical protein 0.0922 0.2003 0.1999
Loa Loa (eye worm) hypothetical protein 0.0049 0.0065 0.0061
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0564 0.1207 0.1207
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0292 0.0604 0.0603
Trichomonas vaginalis PIKK family atypical protein kinase 0.1517 0.3324 0.3321
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0856 0.1855 0.1855
Trichomonas vaginalis PIKK family atypical protein kinase 0.4524 1 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0856 0.1855 0.1855
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0057 0.0083 0.0082
Loa Loa (eye worm) hypothetical protein 0.0661 0.1424 0.142
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0292 0.0604 0.0578
Echinococcus multilocularis hyperpolarization activated cyclic 0.0022 0.0005 0.0005
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0032 0.0027 0.0023
Loa Loa (eye worm) hypothetical protein 0.0953 0.2072 0.2069
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0028 0.0023
Schistosoma mansoni immunophilin 0.0049 0.0065 0.0061
Trichomonas vaginalis immunophilin, putative 0.0057 0.0083 0.0078
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0292 0.0604 0.0599
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0292 0.0604 0.0599
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0111 0.0203 0.0199
Echinococcus granulosus serine protein kinase ATM 0.0856 0.1855 0.1855
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0032 0.0027 0.0027
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1517 0.3324 0.3324
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0057 0.0083 0.0082
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1517 0.3324 0.3321
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0292 0.0604 0.0603
Trichomonas vaginalis PIKK family atypical protein kinase 0.2439 0.5371 0.5369
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0057 0.0083 0.5
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0292 0.0604 0.0599
Entamoeba histolytica hypothetical protein 0.0292 0.0604 0.0603
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0292 0.0604 0.0604
Trichomonas vaginalis PIKK family atypical protein kinase 0.2676 0.5898 0.5896
Leishmania major phosphatidylinositol 4-kinase, putative 0.0292 0.0604 0.0525
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0057 0.0083 0.0082
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0292 0.0604 0.0603
Trichomonas vaginalis PIKK family atypical protein kinase 0.2703 0.5957 0.5956
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0661 0.1424 0.1424
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0292 0.0604 0.0599
Loa Loa (eye worm) hypothetical protein 0.0564 0.1207 0.1203
Mycobacterium leprae conserved hypothetical protein 0.0292 0.0604 0.5
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0049 0.0065 0.0065
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0292 0.0604 0.0599
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0057 0.0083 0.0082
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0292 0.0604 0.0784
Loa Loa (eye worm) hypothetical protein 0.0032 0.0027 0.0023
Leishmania major hypothetical protein, unknown function 0.0292 0.0604 0.0525
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.4524 1 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0292 0.0604 0.0604
Trichomonas vaginalis fk506-binding protein, putative 0.0057 0.0083 0.0078
Toxoplasma gondii target of rapamycin (TOR), putative 0.3365 0.7426 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0856 0.1855 0.1852
Trichomonas vaginalis PIKK family atypical protein kinase 0.2443 0.5379 0.5377
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0292 0.0604 0.0599

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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