Detailed information for compound 1638508

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 326.438 | Formula: C13H18N4O2S2
  • H donors: 1 H acceptors: 2 LogP: 3.7 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=C(N1CCCCCCC1)N/N=C/c1ccc(s1)[N+](=O)[O-]
  • InChi: 1S/C13H18N4O2S2/c18-17(19)12-7-6-11(21-12)10-14-15-13(20)16-8-4-2-1-3-5-9-16/h6-7,10H,1-5,8-9H2,(H,15,20)/b14-10+
  • InChiKey: ROXFTSUHHGNAFH-GXDHUFHOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0368 0.061 0.0596
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0109 0.0155 0.014
Trichomonas vaginalis PIKK family atypical protein kinase 0.3374 0.5901 0.5895
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0368 0.061 0.0596
Giardia lamblia Hypothetical protein 0.0368 0.061 0.061
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0368 0.061 0.061
Trichomonas vaginalis immunophilin, putative 0.0109 0.0155 0.014
Trichomonas vaginalis PIKK family atypical protein kinase 0.3075 0.5374 0.5367
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0368 0.061 0.0589
Schistosoma mansoni hypothetical protein 0.0368 0.061 0.0607
Trichomonas vaginalis conserved hypothetical protein 0.0711 0.1213 0.12
Trichomonas vaginalis conserved hypothetical protein 0.0834 0.143 0.1417
Trichomonas vaginalis PIKK family atypical protein kinase 0.3408 0.596 0.5954
Echinococcus multilocularis 0.0368 0.061 0.061
Entamoeba histolytica PH domain containing protein kinase, putative 0.0023 0.0004 0.0004
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0368 0.061 0.061
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0023 0.0008
Schistosoma mansoni immunophilin 0.0109 0.0155 0.0151
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0368 0.061 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0368 0.061 0.0596
Onchocerca volvulus 0.0368 0.061 0.5
Schistosoma mansoni immunophilin 0.0094 0.0128 0.0125
Trichomonas vaginalis PIKK family atypical protein kinase 0.308 0.5382 0.5376
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0368 0.061 0.061
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1079 0.1861 0.1849
Leishmania major phosphatidylinositol kinase, putative 0.0368 0.061 0.0463
Trichomonas vaginalis PIKK family atypical protein kinase 0.4242 0.7428 0.7424
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0109 0.0155 0.5
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.5703 1 1
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0109 0.0155 0.014
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1079 0.1861 0.1858
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.5703 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1079 0.1861 0.1849
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0368 0.061 0.0798
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1913 0.3329 0.3314
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.003 0.0015 0.0011
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0368 0.061 0.0596
Echinococcus granulosus serine/threonine protein kinase 0.0023 0.0004 0.0004
Brugia malayi FAT domain containing protein 0.0834 0.143 0.1417
Onchocerca volvulus 0.0368 0.061 0.5
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0151 0.0228 0.0228
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0368 0.061 0.061
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0109 0.0155 0.0132
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0094 0.0128 0.0128
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0023 0.0008
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1202 0.2078 0.2779
Loa Loa (eye worm) AGC/AKT protein kinase 0.0034 0.0023 0.0008
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1913 0.3329 0.3329
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0109 0.0155 0.0155
Loa Loa (eye worm) phosphatidylinositol 3 0.1913 0.3329 0.3319
Echinococcus multilocularis voltage gated potassium channel 0.0044 0.0039 0.0039
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1079 0.1861 0.1861
Echinococcus multilocularis hyperpolarization activated cyclic 0.003 0.0015 0.0015
Echinococcus granulosus cyclic nucleotide gated cation channel 0.003 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.1079 0.1861 0.1849
Loa Loa (eye worm) phosphatidylinositol 3 0.0368 0.061 0.0596
Entamoeba histolytica PH domain containing protein kinase, putative 0.0023 0.0004 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.3374 0.5901 0.5895
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.0004 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.153 0.2656 0.2645
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.003 0.0015 0.0015
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0109 0.0155 0.5
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0711 0.1213 0.1213
Loa Loa (eye worm) hypothetical protein 0.0094 0.0128 0.0113
Loa Loa (eye worm) hypothetical protein 0.1162 0.2008 0.1996
Giardia lamblia Phosphatidylinositol 4-kinase 0.0368 0.061 0.061
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0368 0.061 0.061
Schistosoma mansoni voltage-gated potassium channel 0.0164 0.0252 0.0248
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.003 0.0015 0.0011
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1079 0.1861 0.1861
Trichomonas vaginalis PIKK family atypical protein kinase 0.4242 0.7428 0.7424
Trichomonas vaginalis PIKK family atypical protein kinase 0.308 0.5382 0.5376
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0368 0.061 0.0596
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0834 0.143 0.143
Trichomonas vaginalis PIKK family atypical protein kinase 0.4536 0.7946 0.7943
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0368 0.061 0.061
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0368 0.061 0.061
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1913 0.3329 0.3314
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0368 0.061 0.0596
Trichomonas vaginalis PIKK family atypical protein kinase 0.5703 1 1
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0368 0.061 0.061
Loa Loa (eye worm) FKBP5 protein 0.0109 0.0155 0.014
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0368 0.061 0.0463
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0368 0.061 0.061
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0368 0.061 0.0596
Trichomonas vaginalis PIKK family atypical protein kinase 0.4869 0.8532 0.853
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0368 0.061 0.061
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0368 0.061 1
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0368 0.061 0.061
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0368 0.061 0.0798
Trichomonas vaginalis PIKK family atypical protein kinase 0.1913 0.3329 0.3319
Entamoeba histolytica hypothetical protein 0.1079 0.1861 0.1861
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0368 0.061 0.0589
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0368 0.061 0.061
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0015 0.0011
Leishmania major hypothetical protein, unknown function 0.0368 0.061 0.0463
Trichomonas vaginalis PIKK family atypical protein kinase 0.5703 1 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0368 0.061 0.5
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.003 0.0015 0.0015
Schistosoma mansoni 60S ribosomal protein L21 0.0024 0.0004 0.0001
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0368 0.061 0.0589
Entamoeba histolytica hypothetical protein 0.0368 0.061 0.061
Schistosoma mansoni voltage-gated potassium channel 0.0164 0.0252 0.0248
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0109 0.0155 0.0155
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.003 0.0015 0.0015
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0368 0.061 0.0596
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0141 0.021 0.0195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0711 0.1213 0.12
Loa Loa (eye worm) phosphatidylinositol 3 0.0368 0.061 0.0596
Trichomonas vaginalis PIKK family atypical protein kinase 0.1913 0.3329 0.3319
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0109 0.0155 0.014
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0023 0.0004 0.0004
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.5703 1 1
Echinococcus multilocularis rac serine:threonine kinase 0.0023 0.0004 0.0004
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0368 0.061 1
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0109 0.0155 0.0155
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2369 0.4132 0.4118
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0368 0.061 0.061
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0044 0.0039 0.0039
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1913 0.3329 0.3319
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0368 0.061 0.061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0368 0.061 0.0596
Plasmodium vivax hypothetical protein 0.0368 0.061 1
Brugia malayi p70 ribosomal S6 kinase beta 0.0032 0.0019 0.0004
Echinococcus multilocularis hyperpolarization activated cyclic 0.003 0.0015 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.5703 1 1
Loa Loa (eye worm) hypothetical protein 0.0711 0.1213 0.12
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0368 0.061 0.0596
Schistosoma mansoni fkbp-rapamycin associated protein 0.1079 0.1861 0.1858
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0109 0.0155 0.014
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0109 0.0155 0.0155
Trypanosoma brucei target of rapamycin kinase 3, putative 0.4541 0.7954 0.795
Trichomonas vaginalis PIKK family atypical protein kinase 0.3075 0.5374 0.5367
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0368 0.061 0.0607
Trichomonas vaginalis PIKK family atypical protein kinase 0.3408 0.596 0.5954
Toxoplasma gondii FATC domain-containing protein 0.1079 0.1861 0.2486
Loa Loa (eye worm) phosphatidylinositol 3 0.0368 0.061 0.0596
Trichomonas vaginalis PIKK family atypical protein kinase 0.1913 0.3329 0.3319
Loa Loa (eye worm) phosphatidylinositol kinase 0.0368 0.061 0.0596
Plasmodium vivax hypothetical protein, conserved 0.0368 0.061 1
Loa Loa (eye worm) phosphatidylinositol 3 0.5703 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.4242 0.7428 0.7424
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0368 0.061 0.061
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0368 0.061 0.0607
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0109 0.0155 0.0155
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.4541 0.7954 0.7922
Entamoeba histolytica protein kinase, putative 0.0034 0.0023 0.0023
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0023 0.0008
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1079 0.1861 0.1861
Schistosoma mansoni immunophilin 0.0109 0.0155 0.0151
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.5703 1 1
Loa Loa (eye worm) hypothetical protein 0.0368 0.061 0.0596
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0368 0.061 0.0607
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0368 0.061 0.061
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0039 0.0036
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0368 0.061 0.0596
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.003 0.0015 0.0011
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.5703 1 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0151 0.0228 0.0228
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0368 0.061 0.061
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.003 0.0015 0.0015
Entamoeba histolytica protein kinase, putative 0.0034 0.0023 0.0023
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0368 0.061 0.061
Trypanosoma cruzi target of rapamycin kinase 3 0.4541 0.7954 0.7954
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0368 0.061 0.0596
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1079 0.1861 0.1861
Trichomonas vaginalis PIKK family atypical protein kinase 0.4536 0.7946 0.7943
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0368 0.061 0.061
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1079 0.1861 0.1861
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0368 0.061 0.061
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0023 0.0008
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0109 0.0155 0.0151
Mycobacterium leprae conserved hypothetical protein 0.0368 0.061 0.5
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0368 0.061 0.061
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0368 0.061 0.0607
Trichomonas vaginalis PIKK family atypical protein kinase 0.4536 0.7946 0.7943
Trichomonas vaginalis PIKK family atypical protein kinase 0.1913 0.3329 0.3319
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0368 0.061 0.0596
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0039 0.0036
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1913 0.3329 0.3329
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0368 0.061 0.0596
Trichomonas vaginalis fk506-binding protein, putative 0.0109 0.0155 0.014
Echinococcus granulosus hyperpolarization activated cyclic 0.003 0.0015 0.0015
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1913 0.3329 0.3329
Entamoeba histolytica hypothetical protein 0.0368 0.061 0.061
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0109 0.0155 0.0155
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.5703 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0368 0.061 0.061
Brugia malayi Protein kinase domain containing protein 0.0034 0.0023 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.3408 0.596 0.5954
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1913 0.3329 0.3224
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0151 0.0228 0.0213
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0368 0.061 0.0596
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.5703 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0368 0.061 0.0596
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0109 0.0155 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0368 0.061 0.0596
Trichomonas vaginalis PIKK family atypical protein kinase 0.1913 0.3329 0.3319
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.5703 1 1
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0032 0.0019 0.0004
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0044 0.0039 0.0024
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.5703 1 1
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0368 0.061 0.061
Loa Loa (eye worm) hypothetical protein 0.0368 0.061 0.0596
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0151 0.0228 0.0213
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0368 0.061 0.0607
Echinococcus multilocularis fk506 binding protein 0.0109 0.0155 0.0155
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0368 0.061 0.0607
Trichomonas vaginalis PIKK family atypical protein kinase 0.3702 0.6479 0.6473
Entamoeba histolytica protein kinase, putative 0.0032 0.0019 0.0019
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1913 0.3329 0.3329
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0368 0.061 1
Echinococcus multilocularis serine protein kinase ATM 0.1079 0.1861 0.1861
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0368 0.061 0.0596
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0368 0.061 0.0596
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.5703 1 1
Leishmania major hypothetical protein, conserved 0.0368 0.061 0.0463
Loa Loa (eye worm) phosphatidylinositol 3 0.0368 0.061 0.0596
Entamoeba histolytica protein kinase rad3, putative 0.1079 0.1861 0.1861
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0368 0.061 0.061
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.003 0.0015 0.0011
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0023 0.0008
Leishmania major phosphatidylinositol 3-kinase, putative 0.1913 0.3329 0.3224
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0368 0.061 0.0596
Trichomonas vaginalis PIKK family atypical protein kinase 0.308 0.5382 0.5376
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.003 0.0015 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.4536 0.7946 0.7943
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0368 0.061 0.0596
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2697 0.4709 0.4697
Echinococcus granulosus voltage gated potassium channel 0.0044 0.0039 0.0039
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0368 0.061 0.061
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0109 0.0155 0.0155
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1079 0.1861 0.1843
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1913 0.3329 0.3326
Trichomonas vaginalis PIKK family atypical protein kinase 0.3075 0.5374 0.5367
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0368 0.061 0.0596
Loa Loa (eye worm) hypothetical protein 0.0131 0.0193 0.0178
Trichomonas vaginalis PIKK family atypical protein kinase 0.308 0.5382 0.5376
Trichomonas vaginalis PIKK family atypical protein kinase 0.4536 0.7946 0.7943
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0368 0.061 0.061
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0368 0.061 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1079 0.1861 0.1849
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0368 0.061 0.0596
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0109 0.0155 0.2534
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0368 0.061 0.061
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0109 0.0155 0.0155
Toxoplasma gondii target of rapamycin (TOR), putative 0.4242 0.7428 1
Echinococcus granulosus serine protein kinase ATM 0.1079 0.1861 0.1861
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0368 0.061 0.0798
Echinococcus multilocularis Zinc finger, PHD finger 0.0368 0.061 0.061
Leishmania major phosphatidylinositol 3-kinase, putative 0.0368 0.061 0.0463
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0094 0.0128 0.0128
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.003 0.0015 0.0011
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0109 0.0155 0.0155
Echinococcus granulosus hyperpolarization activated cyclic 0.003 0.0015 0.0015
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0368 0.061 0.061
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0109 0.0155 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.1079 0.1861 0.1849
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0834 0.143 0.143
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0368 0.061 0.0607
Loa Loa (eye worm) hypothetical protein 0.0044 0.0039 0.0024
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0044 0.0039 0.0039
Entamoeba histolytica hypothetical protein 0.0368 0.061 0.061
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0023 0.0008
Leishmania major phosphatidylinositol 4-kinase, putative 0.0368 0.061 0.0463
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0368 0.061 0.061
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0109 0.0155 0.0132
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0368 0.061 0.061
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0109 0.0155 0.014
Loa Loa (eye worm) hypothetical protein 0.1202 0.2078 0.2066
Giardia lamblia GTOR 0.5703 1 1
Entamoeba histolytica hypothetical protein 0.0368 0.061 0.061
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0023 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.4242 0.7428 0.7424
Trichomonas vaginalis PIKK family atypical protein kinase 0.4242 0.7428 0.7424
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0368 0.061 0.0798
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0368 0.061 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0368 0.061 0.0596
Trypanosoma cruzi Protein kinase B 0.0023 0.0004 0.0004
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0368 0.061 0.061
Leishmania major phosphatidylinositol kinase related protein, putative 0.0368 0.061 0.0463
Trichomonas vaginalis PIKK family atypical protein kinase 0.4242 0.7428 0.7424
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0368 0.061 0.061
Schistosoma mansoni hypothetical protein 0.0834 0.143 0.1427
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0141 0.021 0.0195
Trichomonas vaginalis PIKK family atypical protein kinase 0.3826 0.6695 0.669
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0368 0.061 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.4242 0.7428 0.7424
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0368 0.061 0.0589
Loa Loa (eye worm) hypothetical protein 0.0834 0.143 0.1417
Trichomonas vaginalis conserved hypothetical protein 0.1202 0.2078 0.2066
Echinococcus granulosus cyclic nucleotide gated cation channel 0.003 0.0015 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.1079 0.1861 0.1849
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0368 0.061 0.061
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0368 0.061 0.061
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0368 0.061 0.0798
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0109 0.0155 0.2534
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.5703 1 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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