Detailed information for compound 1645011

Basic information

Technical information
  • TDR Targets ID: 1645011
  • Name: 1,5,2,4-Dioxadithiocane 2,2,4,4-tetraoxide
  • MW: 216.233 | Formula: C4H8O6S2
  • H donors: 0 H acceptors: 4 LogP: -0.7 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=S1(=O)OCCCOS(=O)(=O)C1
  • InChi: 1S/C4H8O6S2/c5-11(6)4-12(7,8)10-3-1-2-9-11/h1-4H2
  • InChiKey: APPZESCOGKWYIH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 99591-72-7
  • 1,5,2,4-Dioxadithiocane, 2,2,4,4-tetraoxide
  • NSC348963
  • NCI60_003100

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0106 0.0237 0.0236
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0106 0.0237 0.0233
Trypanosoma cruzi target of rapamycin kinase 3 0.2902 0.7951 0.795
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0235 0.0592 1
Trichomonas vaginalis conserved hypothetical protein 0.0454 0.1196 0.1194
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0689 0.1845 0.1843
Trichomonas vaginalis PIKK family atypical protein kinase 0.3644 1 1
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0235 0.0592 0.0592
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0235 0.0592 1
Toxoplasma gondii FATC domain-containing protein 0.0689 0.1845 0.2456
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0235 0.0592 0.0589
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1222 0.3316 0.3316
Trichomonas vaginalis PIKK family atypical protein kinase 0.2178 0.5952 0.5951
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0235 0.0592 0.0589
Trichomonas vaginalis PIKK family atypical protein kinase 0.1965 0.5365 0.5364
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0106 0.0237 0.0233
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.2902 0.7951 0.7901
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0235 0.0592 0.0591
Echinococcus multilocularis voltage gated potassium channel 0.0032 0.0031 0.0031
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0035 0.0032
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0689 0.1845 0.1843
Trichomonas vaginalis PIKK family atypical protein kinase 0.2711 0.7423 0.7422
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0235 0.0592 0.0592
Leishmania major phosphatidylinositol kinase, putative 0.0235 0.0592 0.0364
Entamoeba histolytica protein kinase, putative 0.0033 0.0035 0.0035
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0235 0.0592 0.0589
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0235 0.0592 0.0589
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0235 0.0592 0.0591
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.3644 1 1
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0022 0.0003 0.0003
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0106 0.0237 0.0236
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.3644 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.3644 1 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0022 0.0003 0.0003
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0235 0.0592 0.0589
Entamoeba histolytica hypothetical protein 0.0235 0.0592 0.0591
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0023 0.0006 0.0006
Leishmania major hypothetical protein, conserved 0.0235 0.0592 0.0364
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1222 0.3316 0.3314
Trichomonas vaginalis PIKK family atypical protein kinase 0.0689 0.1845 0.1843
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0235 0.0592 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0235 0.0592 0.0591
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0235 0.0592 0.0761
Trypanosoma cruzi Protein kinase B 0.0023 0.0006 0.0006
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0106 0.0237 0.399
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0022 0.0003 0.0003
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0106 0.0237 0.0233
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0235 0.0592 0.0591
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0235 0.0592 0.0592
Schistosoma mansoni voltage-gated potassium channel 0.012 0.0275 0.0272
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0106 0.0237 0.399
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0235 0.0592 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0454 0.1196 0.1196
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1222 0.3316 0.3154
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0106 0.0237 0.0233
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0021 0.0001 0.0001
Giardia lamblia GTOR 0.3644 1 1
Loa Loa (eye worm) hypothetical protein 0.0235 0.0592 0.0589
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0235 0.0592 0.0589
Echinococcus multilocularis hyperpolarization activated cyclic 0.0022 0.0003 0.0003
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.3644 1 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0235 0.0592 0.0761
Entamoeba histolytica protein kinase, putative 0.0031 0.003 0.0029
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0235 0.0592 0.0591
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1514 0.412 0.4099
Trichomonas vaginalis PIKK family atypical protein kinase 0.1222 0.3316 0.3314
Trichomonas vaginalis PIKK family atypical protein kinase 0.0235 0.0592 0.0589
Brugia malayi Protein kinase domain containing protein 0.0033 0.0035 0.0032
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0235 0.0592 0.0589
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0022 0.0003 0.0003
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0689 0.1845 0.1845
Echinococcus multilocularis hyperpolarization activated cyclic 0.0022 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0092 0.0196 0.0193
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0235 0.0592 0.0592
Loa Loa (eye worm) hypothetical protein 0.0743 0.1993 0.199
Trichomonas vaginalis PIKK family atypical protein kinase 0.0454 0.1196 0.1194
Schistosoma mansoni voltage-gated potassium channel 0.012 0.0275 0.0272
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0022 0.0003 0.0003
Mycobacterium tuberculosis Conserved hypothetical protein 0.0235 0.0592 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0978 0.2641 0.2639
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0022 0.0003 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.2156 0.5893 0.5891
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0106 0.0237 0.0236
Echinococcus granulosus serine/threonine protein kinase 0.0023 0.0006 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.2899 0.7942 0.7942
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0533 0.1414 0.1414
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0235 0.0592 0.0761
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0235 0.0592 0.0591
Entamoeba histolytica hypothetical protein 0.0689 0.1845 0.1845
Trichomonas vaginalis PIKK family atypical protein kinase 0.2711 0.7423 0.7422
Trichomonas vaginalis PIKK family atypical protein kinase 0.1968 0.5373 0.5372
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0235 0.0592 0.0591
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0235 0.0592 0.0589
Mycobacterium leprae conserved hypothetical protein 0.0235 0.0592 0.5
Plasmodium vivax hypothetical protein 0.0235 0.0592 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.3644 1 1
Loa Loa (eye worm) hypothetical protein 0.0235 0.0592 0.0589
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1222 0.3316 0.3314
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0235 0.0592 0.0589
Trichomonas vaginalis PIKK family atypical protein kinase 0.3112 0.8529 0.8529
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0106 0.0237 0.0236
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0235 0.0592 0.0591
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0235 0.0592 0.0589
Loa Loa (eye worm) phosphatidylinositol 3 0.0235 0.0592 0.0589
Trichomonas vaginalis PIKK family atypical protein kinase 0.2178 0.5952 0.5951
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0533 0.1414 0.1414
Loa Loa (eye worm) hypothetical protein 0.0454 0.1196 0.1194
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0235 0.0592 0.0589
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0021 0.0001 0.0001
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0235 0.0592 0.0591
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0235 0.0592 0.0589
Echinococcus multilocularis fk506 binding protein 0.0106 0.0237 0.0237
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0235 0.0592 0.0364
Trichomonas vaginalis PIKK family atypical protein kinase 0.2156 0.5893 0.5891
Trichomonas vaginalis PIKK family atypical protein kinase 0.1965 0.5365 0.5364
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0235 0.0592 0.0591
Echinococcus multilocularis Zinc finger, PHD finger 0.0235 0.0592 0.0592
Entamoeba histolytica hypothetical protein 0.0235 0.0592 0.0591
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0106 0.0237 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0689 0.1845 0.1843
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0235 0.0592 0.0592
Trichomonas vaginalis PIKK family atypical protein kinase 0.1968 0.5373 0.5372
Trichomonas vaginalis fk506-binding protein, putative 0.0106 0.0237 0.0233
Trichomonas vaginalis PIKK family atypical protein kinase 0.2711 0.7423 0.7422
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0235 0.0592 0.0592
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.3644 1 1
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0235 0.0592 0.0559
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0235 0.0592 0.0589
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0235 0.0592 0.0591
Schistosoma mansoni immunophilin 0.0092 0.0196 0.0193
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0032 0.0031 0.0031
Trichomonas vaginalis immunophilin, putative 0.0106 0.0237 0.0233
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0235 0.0592 0.0592
Echinococcus granulosus hyperpolarization activated cyclic 0.0022 0.0003 0.0003
Leishmania major phosphatidylinositol 4-kinase, putative 0.0235 0.0592 0.0364
Brugia malayi FAT domain containing protein 0.0533 0.1414 0.1411
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.3644 1 1
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0106 0.0237 0.0202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0689 0.1845 0.1843
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1222 0.3316 0.3292
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0235 0.0592 0.0591
Loa Loa (eye worm) hypothetical protein 0.0689 0.1845 0.1843
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0106 0.0237 0.0236
Trichomonas vaginalis PIKK family atypical protein kinase 0.1222 0.3316 0.3314
Trichomonas vaginalis PIKK family atypical protein kinase 0.1222 0.3316 0.3314
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0035 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0689 0.1845 0.1843
Schistosoma mansoni immunophilin 0.0106 0.0237 0.0233
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0092 0.0196 0.0196
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0032 0.0031 0.0028
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0235 0.0592 0.0589
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.011 0.0247 0.0244
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0235 0.0592 0.0589
Echinococcus granulosus voltage gated potassium channel 0.0032 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0768 0.2062 0.206
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0106 0.0237 0.0236
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.3644 1 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0768 0.2062 0.275
Onchocerca volvulus 0.0235 0.0592 0.5
Loa Loa (eye worm) AGC/AKT protein kinase 0.0033 0.0035 0.0032
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0235 0.0592 0.0591
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0035 0.0032
Entamoeba histolytica hypothetical protein 0.0235 0.0592 0.0591
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0235 0.0592 0.0589
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0106 0.0237 0.0237
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0235 0.0592 0.0761
Loa Loa (eye worm) phosphatidylinositol 3 0.0235 0.0592 0.0589
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0235 0.0592 0.0591
Echinococcus granulosus serine threonine protein kinase nrc 0.0021 0.0001 0.0001
Toxoplasma gondii target of rapamycin (TOR), putative 0.2711 0.7423 1
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0235 0.0592 0.0589
Trichomonas vaginalis PIKK family atypical protein kinase 0.2711 0.7423 0.7422
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0235 0.0592 0.0592
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0032 0.0031 0.0031
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0235 0.0592 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2711 0.7423 0.7422
Loa Loa (eye worm) hypothetical protein 0.0533 0.1414 0.1411
Trichomonas vaginalis PIKK family atypical protein kinase 0.2711 0.7423 0.7422
Trichomonas vaginalis PIKK family atypical protein kinase 0.2445 0.6689 0.6688
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0235 0.0592 0.0592
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0106 0.0237 0.0236
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0235 0.0592 0.0761
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0106 0.0237 0.0236
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.3644 1 1
Schistosoma mansoni serine/threonine-protein kinase 0.0023 0.0006 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0768 0.2062 0.206
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0235 0.0592 0.0591
Schistosoma mansoni hypothetical protein 0.0533 0.1414 0.1411
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0235 0.0592 0.0589
Giardia lamblia Hypothetical protein 0.0235 0.0592 0.0591
Leishmania major phosphatidylinositol 3-kinase, putative 0.0235 0.0592 0.0364
Entamoeba histolytica protein kinase rad3, putative 0.0689 0.1845 0.1845
Trichomonas vaginalis PIKK family atypical protein kinase 0.1965 0.5365 0.5364
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0235 0.0592 0.0559
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0235 0.0592 0.0591
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0106 0.0237 0.0233
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0235 0.0592 0.0591
Trichomonas vaginalis PIKK family atypical protein kinase 0.1968 0.5373 0.5372
Trichomonas vaginalis PIKK family atypical protein kinase 0.2899 0.7942 0.7942
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0689 0.1845 0.1845
Trichomonas vaginalis PIKK family atypical protein kinase 0.1222 0.3316 0.3314
Trichomonas vaginalis PIKK family atypical protein kinase 0.2711 0.7423 0.7422
Echinococcus multilocularis serine protein kinase ATM 0.0689 0.1845 0.1845
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0235 0.0592 0.0592
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0235 0.0592 0.0589
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0689 0.1845 0.1845
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0235 0.0592 0.0591
Loa Loa (eye worm) FKBP5 protein 0.0106 0.0237 0.0233
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0235 0.0592 0.0592
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0103 0.0227 0.0224
Entamoeba histolytica PH domain containing protein kinase, putative 0.0023 0.0006 0.0006
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0106 0.0237 0.0237
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0022 0.0003 0.0003
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0092 0.0196 0.0196
Schistosoma mansoni hypothetical protein 0.0235 0.0592 0.0589
Plasmodium vivax hypothetical protein, conserved 0.0235 0.0592 1
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0035 0.0032
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0106 0.0237 0.5
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0235 0.0592 0.0592
Schistosoma mansoni fkbp-rapamycin associated protein 0.0689 0.1845 0.1843
Trichomonas vaginalis conserved hypothetical protein 0.0533 0.1414 0.1411
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.3644 1 1
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0035 0.0032
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0235 0.0592 0.0589
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1222 0.3316 0.3292
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0103 0.0227 0.0224
Trichomonas vaginalis PIKK family atypical protein kinase 0.3644 1 1
Brugia malayi p70 ribosomal S6 kinase beta 0.0031 0.003 0.0027
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0106 0.0237 0.0237
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.011 0.0247 0.0244
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0235 0.0592 0.0589
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0235 0.0592 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2366 0.6472 0.6471
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1222 0.3316 0.3315
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0031 0.003 0.0027
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0235 0.0592 0.0589
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0235 0.0592 0.0592
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0031 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.1222 0.3316 0.3314
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0689 0.1845 0.1816
Leishmania major phosphatidylinositol kinase related protein, putative 0.0235 0.0592 0.0364
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0022 0.0003 0.0003
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0235 0.0592 0.0589
Trichomonas vaginalis PIKK family atypical protein kinase 0.1968 0.5373 0.5372
Leishmania major hypothetical protein, unknown function 0.0235 0.0592 0.0364
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0235 0.0592 1
Echinococcus granulosus serine protein kinase ATM 0.0689 0.1845 0.1845
Loa Loa (eye worm) phosphatidylinositol kinase 0.0235 0.0592 0.0589
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0235 0.0592 0.0589
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.3644 1 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0235 0.0592 0.0589
Loa Loa (eye worm) phosphatidylinositol 3 0.0235 0.0592 0.0589
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.1723 0.4699 0.468
Trichomonas vaginalis PIKK family atypical protein kinase 0.2899 0.7942 0.7942
Loa Loa (eye worm) hypothetical protein 0.0095 0.0207 0.0204
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0035 0.0032
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0235 0.0592 0.0591
Schistosoma mansoni serine/threonine-protein kinase 0.0023 0.0006 0.0003
Loa Loa (eye worm) phosphatidylinositol 3 0.0235 0.0592 0.0589
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0035 0.0032
Trypanosoma brucei target of rapamycin kinase 3, putative 0.2902 0.7951 0.7943
Entamoeba histolytica PH domain containing protein kinase, putative 0.0023 0.0006 0.0006
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.011 0.0247 0.0247
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0235 0.0592 0.0591
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0031 0.0028
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0235 0.0592 0.0592
Loa Loa (eye worm) phosphatidylinositol 3 0.0235 0.0592 0.0589
Echinococcus multilocularis 0.0235 0.0592 0.0592
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0106 0.0237 0.0202
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0689 0.1845 0.1845
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0235 0.0592 0.0559
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0689 0.1845 0.1845
Trichomonas vaginalis PIKK family atypical protein kinase 0.2899 0.7942 0.7942
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0235 0.0592 0.0559
Onchocerca volvulus 0.0235 0.0592 0.5
Entamoeba histolytica protein kinase, putative 0.0033 0.0035 0.0035
Schistosoma mansoni immunophilin 0.0106 0.0237 0.0233
Loa Loa (eye worm) phosphatidylinositol 3 0.1222 0.3316 0.3314
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0235 0.0592 0.0589
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1222 0.3316 0.3316
Echinococcus multilocularis rac serine:threonine kinase 0.0023 0.0006 0.0006
Leishmania major phosphatidylinositol 3-kinase, putative 0.1222 0.3316 0.3154
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0235 0.0592 0.0589
Trichomonas vaginalis PIKK family atypical protein kinase 0.2899 0.7942 0.7942
Echinococcus granulosus potassium voltage gated channel subfamily H 0.011 0.0247 0.0247
Trichomonas vaginalis PIKK family atypical protein kinase 0.2178 0.5952 0.5951
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1222 0.3316 0.3315
Trichomonas vaginalis PIKK family atypical protein kinase 0.0235 0.0592 0.0589
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0235 0.0592 0.0589
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.3644 1 1
Giardia lamblia Phosphatidylinositol 4-kinase 0.0235 0.0592 0.0591
Loa Loa (eye worm) hypothetical protein 0.0032 0.0031 0.0028
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0106 0.0237 0.0233
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.3644 1 1
Entamoeba histolytica hypothetical protein 0.0235 0.0592 0.0591

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.283 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.267 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.229 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.164 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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