Detailed information for compound 1656945

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 379.474 | Formula: C16H13NO4S3
  • H donors: 2 H acceptors: 4 LogP: 3.82 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CSc1ccc(c2c1cccc2)NS(=O)(=O)c1cccs1
  • InChi: 1S/C16H13NO4S3/c18-15(19)10-23-14-8-7-13(11-4-1-2-5-12(11)14)17-24(20,21)16-6-3-9-22-16/h1-9,17H,10H2,(H,18,19)
  • InChiKey: YHFFQGNJFRJYSR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis beta tubulin 0.0142 0.0555 0.0721
Echinococcus multilocularis Niemann Pick C1 protein 0.0106 0.0397 0.0509
Plasmodium vivax tubulin alpha chain, putative 0.0264 0.1095 0.4063
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.1253 0.4642
Brugia malayi Tubulin beta-1 chain 0.0142 0.0555 0.0766
Leishmania major alpha tubulin 0.0264 0.1095 0.4046
Loa Loa (eye worm) hypothetical protein 0.0026 0.004 0.022
Brugia malayi Tubulin beta chain 0.008 0.0282 0.0389
Loa Loa (eye worm) beta-tubulin 0.0142 0.0555 0.4172
Plasmodium falciparum alpha tubulin 1 0.0264 0.1095 0.4063
Echinococcus granulosus dnaJ subfamily B 0.0397 0.1683 1
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0231 0.1278
Trypanosoma brucei epsilon tubulin 0.0142 0.0555 0.2007
Leishmania major beta tubulin 0.0142 0.0555 0.2017
Echinococcus granulosus peroxisome assembly protein 26 0.0264 0.1095 0.6466
Leishmania major beta tubulin 0.0142 0.0555 0.2017
Echinococcus multilocularis tubulin epsilon chain 0.0142 0.0555 0.0721
Loa Loa (eye worm) tubulin alpha 2 0.0202 0.0822 0.6215
Echinococcus multilocularis protein patched 0.0046 0.0129 0.0148
Trypanosoma cruzi tubulin delta chain 0.0062 0.02 0.068
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.014 0.0193
Schistosoma mansoni alpha tubulin 0.0264 0.1095 0.6466
Leishmania major beta tubulin 0.0142 0.0555 0.2017
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.004 0.117
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0231 0.1278
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.004 0.0234
Leishmania major alpha tubulin 0.0264 0.1095 0.4046
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0099 0.048
Echinococcus multilocularis tubulin alpha 0.0142 0.0555 0.0721
Trichomonas vaginalis tubulin alpha chain, putative 0.008 0.0282 0.2424
Onchocerca volvulus 0.008 0.0282 0.0264
Echinococcus granulosus Tubulin beta 2C chain 0.0142 0.0555 0.3224
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0108 0.0405 0.2319
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0021 0.0019 0.0028
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0184 0.0739 0.6683
Mycobacterium ulcerans monoamine oxidase 0.0021 0.0019 0.0061
Leishmania major beta tubulin 0.0142 0.0555 0.2017
Echinococcus multilocularis snurportin 1 0.0314 0.1315 0.1742
Echinococcus granulosus tubulin subunit beta 0.0142 0.0555 0.3224
Echinococcus granulosus Protein patched homolog 1 0.0046 0.0129 0.066
Entamoeba histolytica tubulin alpha chain, putative 0.0264 0.1095 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0152 0.06 0.0828
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.004 0.0109
Giardia lamblia Telomerase catalytic subunit 0.0622 0.2678 1
Schistosoma mansoni importin beta-1 0.0029 0.0057 0.0228
Schistosoma mansoni tyrosine kinase 0.0081 0.0285 0.1597
Leishmania major alpha tubulin 0.0264 0.1095 0.4046
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.008 0.0282 0.2424
Loa Loa (eye worm) tubulin alpha-2 chain 0.0264 0.1095 0.8309
Brugia malayi hypothetical protein 0.0021 0.0019 0.0026
Leishmania major beta tubulin 0.0142 0.0555 0.2017
Echinococcus multilocularis tubulin alpha chain 0.0264 0.1095 0.1445
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0022 0.0041
Echinococcus multilocularis tubulin alpha 3 chain 0.0264 0.1095 0.1445
Trichomonas vaginalis tubulin epsilon chain, putative 0.0062 0.02 0.1653
Echinococcus granulosus Tubulin alpha 1 chain 0.0264 0.1095 0.6466
Trichomonas vaginalis tubulin gamma chain, putative 0.0142 0.0555 0.497
Echinococcus granulosus transient receptor potential gamma protein 0.0099 0.0364 0.2077
Echinococcus multilocularis tubulin alpha chain 0.0264 0.1095 0.1445
Leishmania major epsilon tubulin, putative 0.0142 0.0555 0.2017
Echinococcus granulosus tubulin alpha 3 chain 0.0264 0.1095 0.6466
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.004 0.0068
Leishmania major gamma-tubulin 0.0142 0.0555 0.2017
Echinococcus multilocularis Tubulin beta 2C chain 0.0142 0.0555 0.0721
Brugia malayi alpha-tubulin 0.0264 0.1095 0.151
Loa Loa (eye worm) hypothetical protein 0.0046 0.0129 0.09
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0296 0.1236 1
Trypanosoma cruzi epsilon tubulin, putative 0.0142 0.0555 0.2017
Schistosoma mansoni hypothetical protein 0.0168 0.0671 0.3919
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0231 0.1689
Mycobacterium ulcerans cell division protein FtsZ 0.0062 0.02 0.1537
Trypanosoma brucei beta tubulin 0.0142 0.0555 0.2007
Loa Loa (eye worm) tubulin beta-2A chain 0.0142 0.0555 0.4172
Toxoplasma gondii RNA-directed DNA polymerase 0.0622 0.2678 1
Echinococcus granulosus tubulin alpha 1C chain 0.0264 0.1095 0.6466
Loa Loa (eye worm) TK/EGFR protein kinase 0.0151 0.0593 0.446
Echinococcus granulosus Tubulin beta 2C chain 0.0142 0.0555 0.3224
Trypanosoma brucei alpha tubulin, putative 0.008 0.0282 0.0979
Trichomonas vaginalis tubulin gamma chain, putative 0.0142 0.0555 0.497
Echinococcus multilocularis short transient receptor potential channel 6 0.0065 0.0216 0.0265
Echinococcus granulosus tubulin delta chain 0.0062 0.02 0.1086
Echinococcus multilocularis short transient receptor potential channel 6 0.0065 0.0216 0.0265
Plasmodium vivax telomerase reverse transcriptase, putative 0.0622 0.2678 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.0556 0.323
Leishmania major alpha tubulin 0.0264 0.1095 0.4046
Brugia malayi Importin beta-1 subunit 0.0029 0.0057 0.0078
Plasmodium falciparum telomerase reverse transcriptase 0.0622 0.2678 1
Echinococcus granulosus beta tubulin 0.0142 0.0555 0.3224
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0058
Leishmania major beta tubulin 0.0142 0.0555 0.2017
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.014 0.0727
Entamoeba histolytica tubulin family protein 0.0142 0.0555 0.497
Treponema pallidum cell division protein FtsZ 0.0062 0.02 0.5
Trichomonas vaginalis tubulin epsilon chain, putative 0.0142 0.0555 0.497
Trypanosoma cruzi beta tubulin, putative 0.0142 0.0555 0.2017
Giardia lamblia Delta tubulin 0.0062 0.02 0.0667
Schistosoma mansoni tubulin subunit alpha 0.0264 0.1095 0.6466
Schistosoma mansoni tubulin subunit beta 0.0142 0.0555 0.3224
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0314 0.1315 1
Leishmania major beta tubulin 0.0142 0.0555 0.2017
Trypanosoma brucei beta tubulin 0.0142 0.0555 0.2007
Schistosoma mansoni cpg binding protein 0.0028 0.005 0.0187
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.0556 0.0722
Trypanosoma brucei beta tubulin 0.0142 0.0555 0.2007
Loa Loa (eye worm) hypothetical protein 0.0106 0.0397 0.2961
Schistosoma mansoni tyrosine kinase 0.0048 0.014 0.0725
Echinococcus granulosus Tubulin beta 2C chain 0.0142 0.0555 0.3224
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0058
Schistosoma mansoni transient receptor potential channel 0.0065 0.0216 0.1186
Brugia malayi Tubulin alpha-2 chain 0.0264 0.1095 0.151
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.004 0.008
Trichomonas vaginalis tubulin beta chain, putative 0.0142 0.0555 0.497
Schistosoma mansoni patched 1 0.0046 0.0129 0.066
Echinococcus granulosus tubulin alpha 3 chain 0.0264 0.1095 0.6466
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0099 0.048
Leishmania major alpha tubulin 0.0264 0.1095 0.4046
Leishmania major beta tubulin 0.0142 0.0555 0.2017
Toxoplasma gondii alpha-tubulin I, putative 0.0264 0.1095 0.4046
Plasmodium falciparum tubulin epsilon chain, putative 0.0142 0.0555 0.204
Echinococcus granulosus alpha tubulin 0.0264 0.1095 0.6466
Trypanosoma cruzi tubulin delta chain 0.0062 0.02 0.068
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.004 0.0293
Brugia malayi Tubulin beta chain 0.0062 0.02 0.0275
Echinococcus multilocularis Tubulin beta 2C chain 0.0142 0.0555 0.0721
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0264 0.1095 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0057 0.0129
Trypanosoma brucei telomerase reverse transcriptase 0.0622 0.2678 1
Brugia malayi RNA binding protein 0.0069 0.0231 0.0319
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0048 0.014 0.0725
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0032 0.0091
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0113 0.0355
Echinococcus multilocularis Tubulin alpha 1 chain 0.0264 0.1095 0.1445
Plasmodium falciparum alpha tubulin 2 0.0264 0.1095 0.4063
Trichomonas vaginalis tubulin gamma chain, putative 0.0062 0.02 0.1653
Loa Loa (eye worm) hypothetical protein 0.0026 0.004 0.022
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.004 0.0234
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0062 0.02 0.1653
Schistosoma mansoni alpha tubulin 0.0264 0.1095 0.6466
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0154 0.0508
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0231 0.1689
Echinococcus granulosus tubulin alpha chain 0.0264 0.1095 0.6466
Plasmodium falciparum tubulin gamma chain 0.0142 0.0555 0.204
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0032 0.0091
Toxoplasma gondii beta-tubulin, putative 0.0142 0.0555 0.2017
Loa Loa (eye worm) hypothetical protein 0.0099 0.0364 0.2708
Echinococcus granulosus insulin receptor 0.0048 0.014 0.0725
Trichomonas vaginalis tubulin epsilon chain, putative 0.0264 0.1095 1
Echinococcus multilocularis beta tubulin 0.0142 0.0555 0.0721
Echinococcus granulosus short transient receptor potential channel 6 0.0065 0.0216 0.1186
Echinococcus granulosus epidermal growth factor receptor 0.0081 0.0285 0.1597
Onchocerca volvulus 0.0028 0.005 0.0031
Brugia malayi TAR-binding protein 0.0069 0.0231 0.0319
Echinococcus multilocularis geminin 0.0168 0.0671 0.0876
Brugia malayi Calcitonin receptor-like protein seb-1 0.0152 0.06 0.0828
Entamoeba histolytica hypothetical protein 0.0039 0.0099 0.0712
Plasmodium vivax tubulin epsilon chain, putative 0.0142 0.0555 0.204
Schistosoma mansoni hypothetical protein 0.0048 0.014 0.0727
Toxoplasma gondii hypothetical protein 0.0048 0.0141 0.0458
Echinococcus multilocularis peroxisome assembly protein 26 0.0264 0.1095 0.1445
Trypanosoma brucei beta tubulin 0.0142 0.0555 0.2007
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0022 0.0005
Echinococcus multilocularis hypothetical protein 0.0264 0.1095 0.1445
Leishmania major beta tubulin 0.0142 0.0555 0.2017
Echinococcus granulosus tubulin alpha chain 0.0264 0.1095 0.6466
Trypanosoma brucei alpha tubulin 0.0264 0.1095 0.4038
Trypanosoma cruzi alpha tubulin, putative 0.0264 0.1095 0.4046
Leishmania major beta tubulin 0.0142 0.0555 0.2017
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0081 0.0285 0.1597
Brugia malayi Tubulin alpha-2 chain 0.0264 0.1095 0.151
Leishmania major alpha tubulin 0.0264 0.1095 0.4046
Echinococcus multilocularis tubulin alpha chain 0.0264 0.1095 0.1445
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.0554 0.2014
Trypanosoma brucei alpha tubulin 0.0264 0.1095 0.4038
Trichomonas vaginalis tubulin epsilon chain, putative 0.0264 0.1095 1
Echinococcus multilocularis expressed conserved protein 0.01 0.0369 0.047
Trichomonas vaginalis tubulin beta chain, putative 0.0264 0.1095 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0142 0.0555 0.0721
Schistosoma mansoni tubulin subunit alpha 0.0264 0.1095 0.6466
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0032 0.0091
Echinococcus granulosus transient receptor potential ion channel A 0.0096 0.035 0.199
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.0554 0.2014
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0142 0.0555 0.2017
Trypanosoma brucei zeta tubulin, putative 0.0062 0.02 0.0667
Mycobacterium ulcerans dehydrogenase 0.0021 0.0019 0.0061
Echinococcus multilocularis tubulin alpha chain 0.0264 0.1095 0.1445
Trichomonas vaginalis tubulin gamma chain, putative 0.0142 0.0555 0.497
Trichomonas vaginalis tubulin alpha chain, putative 0.0142 0.0555 0.497
Loa Loa (eye worm) hypothetical protein 0.0048 0.014 0.0985
Trypanosoma brucei alpha tubulin 0.0264 0.1095 0.4038
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.004 0.0164
Brugia malayi Tubulin alpha chain 0.0264 0.1095 0.151
Entamoeba histolytica hypothetical protein 0.0024 0.0032 0.0091
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0022 0.0013
Echinococcus granulosus tubulin alpha chain 0.0264 0.1095 0.6466
Schistosoma mansoni hypothetical protein 0.0314 0.1315 0.7792
Leishmania major alpha tubulin 0.0264 0.1095 0.4046
Echinococcus granulosus tubulin epsilon chain 0.0142 0.0555 0.3224
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0011 0.0041
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0057 0.0051
Trypanosoma cruzi epsilon tubulin, putative 0.0142 0.0555 0.2017
Brugia malayi Furin-like cysteine rich region family protein 0.0151 0.0593 0.0818
Echinococcus granulosus Niemann Pick C1 protein 0.0152 0.0599 0.349
Schistosoma mansoni tyrosine kinase 0.008 0.0281 0.1575
Leishmania major beta tubulin 0.0142 0.0555 0.2017
Echinococcus multilocularis transient receptor potential gamma protein 0.0099 0.0364 0.0464
Entamoeba histolytica hypothetical protein 0.0039 0.0099 0.0712
Trichomonas vaginalis tubulin beta chain, putative 0.0264 0.1095 1
Brugia malayi Latrophilin receptor protein 2 0.0048 0.014 0.0193
Loa Loa (eye worm) hypothetical protein 0.0202 0.0822 0.6215
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0022 0.0085
Loa Loa (eye worm) tubulin gamma chain 0.0142 0.0555 0.4172
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.004 0.0081
Echinococcus granulosus tubulin alpha 0.0142 0.0555 0.3224
Toxoplasma gondii beta-1 tubulin, putative 0.0142 0.0555 0.2017
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0113 0.0342
Mycobacterium tuberculosis Cell division protein FtsZ 0.0062 0.02 0.1696
Brugia malayi Telomerase reverse transcriptase 0.1656 0.7249 1
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0231 0.0319
Leishmania major beta tubulin 0.0142 0.0555 0.2017
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1704 0.7462 1
Leishmania major alpha tubulin 0.0264 0.1095 0.4046
Echinococcus multilocularis Tubulin alpha 1 chain 0.0264 0.1095 0.1445
Mycobacterium ulcerans hypothetical protein 0.0026 0.004 0.0234
Schistosoma mansoni tubulin subunit beta 0.0142 0.0555 0.3224
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0021 0.0019 0.0028
Brugia malayi latrophilin 2 splice variant baaae 0.0104 0.0387 0.0534
Giardia lamblia Epsilon tubulin 0.0062 0.02 0.0667
Trichomonas vaginalis tubulin, putative 0.008 0.0282 0.2424
Leishmania major beta tubulin 0.0142 0.0555 0.2017
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0019 0.0107
Schistosoma mansoni hypothetical protein 0.0044 0.0121 0.0616
Trichomonas vaginalis tubulin epsilon chain, putative 0.0142 0.0555 0.497
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.0556 0.323
Echinococcus granulosus epidermal growth factor receptor 0.0151 0.0593 0.345
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0556 0.323
Entamoeba histolytica hypothetical protein 0.0039 0.0099 0.0712
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0058
Trichomonas vaginalis tubulin alpha chain, putative 0.008 0.0282 0.2424
Schistosoma mansoni cpg binding protein 0.0029 0.0057 0.0229
Echinococcus multilocularis Niemann Pick C1 protein 0.0152 0.0599 0.078
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0057 0.0142
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0022 0.0013
Trypanosoma brucei mitochondrial DNA polymerase beta 0.03 0.1253 0.4635
Echinococcus granulosus beta tubulin 0.0142 0.0555 0.3224
Echinococcus granulosus tubulin beta 4A class IVa 0.0142 0.0555 0.3224
Giardia lamblia Beta tubulin 0.0142 0.0555 0.2007
Schistosoma mansoni hypothetical protein 0.0044 0.0121 0.0616
Toxoplasma gondii beta tubulin 0.0142 0.0555 0.2017
Loa Loa (eye worm) tubulin alpha chain 0.0264 0.1095 0.8309
Echinococcus granulosus tubulin subunit TubB 0.0264 0.1095 0.6466
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.004 0.0109
Brugia malayi Tubulin gamma chain 0.0142 0.0555 0.0766
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0058
Brugia malayi Tubulin alpha chain 0.0062 0.02 0.0275
Brugia malayi tubulin alpha chain - mouse 0.0264 0.1095 0.151
Trypanosoma cruzi zeta tubulin, putative 0.0062 0.02 0.068
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0142 0.0556 0.4179
Schistosoma mansoni hypothetical protein 0.0168 0.0671 0.3919
Trichomonas vaginalis tubulin, putative 0.008 0.0282 0.2424
Trypanosoma brucei beta tubulin 0.0142 0.0555 0.2007
Echinococcus multilocularis tubulin gamma 1 chain 0.0142 0.0555 0.0721
Schistosoma mansoni tubulin subunit beta 0.0062 0.02 0.1086
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.004 0.0164
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0556 0.323
Echinococcus multilocularis Tubulin beta 2C chain 0.0142 0.0555 0.0721
Plasmodium falciparum protoporphyrinogen oxidase 0.0021 0.0019 0.0028
Schistosoma mansoni transient receptor potential channel 4 0.0099 0.0364 0.2077
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0021 0.0019 0.0028
Plasmodium vivax importin-beta 2, putative 0.0029 0.0057 0.017
Echinococcus multilocularis 0.0047 0.0133 0.0153
Echinococcus multilocularis Tubulin beta 2C chain 0.0142 0.0555 0.0721
Giardia lamblia Beta tubulin 0.0142 0.0555 0.2007
Trichomonas vaginalis tubulin, putative 0.0062 0.02 0.1653
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0023 0.0026 0.0028
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.005 0.0296
Brugia malayi SWIRM domain containing protein 0.0021 0.0019 0.0026
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.004 0.0234
Schistosoma mansoni hypothetical protein 0.0044 0.0121 0.0616
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.004 0.008
Echinococcus multilocularis tubulin alpha 1C chain 0.0264 0.1095 0.1445
Loa Loa (eye worm) hypothetical protein 0.0184 0.0739 0.5581
Echinococcus multilocularis epidermal growth factor receptor 0.0151 0.0593 0.0771
Schistosoma mansoni tubulin subunit beta 0.0142 0.0555 0.3224
Loa Loa (eye worm) hypothetical protein 0.0026 0.004 0.022
Schistosoma mansoni tubulin subunit beta 0.0142 0.0555 0.3224
Schistosoma mansoni hypothetical protein 0.0397 0.1683 1
Echinococcus multilocularis protein dispatched 1 0.0052 0.0157 0.0186
Plasmodium vivax tubulin alpha chain, putative 0.0264 0.1095 0.4063
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0202 0.0822 0.6215
Echinococcus granulosus Tubulin alpha 1 chain 0.0264 0.1095 0.6466
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.004 0.0293
Loa Loa (eye worm) hypothetical protein 0.0037 0.0089 0.0599
Echinococcus multilocularis dnaJ subfamily B 0.0397 0.1683 0.2235
Echinococcus multilocularis tubulin alpha 1C chain 0.0264 0.1095 0.1445
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.014 0.0162
Brugia malayi beta-tubulin, identical 0.0142 0.0555 0.0766
Giardia lamblia Alpha-tubulin 0.0264 0.1095 0.4038
Loa Loa (eye worm) hypothetical protein 0.0152 0.06 0.4517
Brugia malayi RNA, U transporter 1 0.0084 0.0296 0.0409
Trypanosoma brucei epsilon tubulin 0.0142 0.0555 0.2007
Loa Loa (eye worm) hypothetical protein 0.0104 0.0387 0.2882
Schistosoma mansoni hypothetical protein 0.0048 0.014 0.0727
Plasmodium vivax tubulin beta chain, putative 0.0142 0.0555 0.204
Brugia malayi AMP-binding enzyme family protein 0.0026 0.004 0.0055
Schistosoma mansoni tyrosine kinase 0.0048 0.014 0.0725
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0188 0.1018
Schistosoma mansoni tubulin subunit delta 0.0062 0.02 0.1086
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0296 0.1236 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0099 0.0107
Brugia malayi hypothetical protein 0.0039 0.0099 0.0136
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0231 0.1278
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.0129 0.0148
Schistosoma mansoni tubulin subunit gamma 0.0142 0.0555 0.3224
Loa Loa (eye worm) BEN-1 protein 0.0142 0.0555 0.4172
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.0129 0.09
Schistosoma mansoni hypothetical protein 0.0044 0.0121 0.0616
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0057 0.0129
Plasmodium falciparum tubulin beta chain 0.0142 0.0555 0.204
Entamoeba histolytica tubulin alpha-1 chain 0.0264 0.1095 1
Echinococcus multilocularis tubulin alpha chain 0.0264 0.1095 0.1445
Echinococcus granulosus cpg binding protein 0.0029 0.0057 0.0229
Echinococcus multilocularis GPCR, family 2 0.0048 0.014 0.0162
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.014 0.0162
Trypanosoma brucei tubulin delta chain 0.0062 0.02 0.0667
Loa Loa (eye worm) tubulin alpha 2 0.0122 0.0466 0.3487
Leishmania major alpha tubulin 0.0264 0.1095 0.4046
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.004 0.0164
Leishmania major zeta tubulin, putative 0.0062 0.02 0.068
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0129 0.0991
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.016 0.0532
Schistosoma mansoni cpg binding protein 0.0029 0.0057 0.0229
Trypanosoma brucei zeta tubulin 0.0062 0.02 0.0667
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0622 0.2678 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.014 0.0985
Plasmodium falciparum tubulin delta chain, putative 0.0062 0.02 0.0706
Loa Loa (eye worm) alpha-tubulin 0.0264 0.1095 0.8309
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.004 0.0109
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0037 0.0089 0.0095
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.0556 0.0722
Echinococcus multilocularis tubulin delta chain 0.0062 0.02 0.0243
Leishmania major delta tubulin, putative 0.0062 0.02 0.068
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0142 0.0555 0.0721
Trichomonas vaginalis tubulin beta chain, putative 0.0264 0.1095 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0057 0.0348
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0202 0.0822 0.7455
Plasmodium falciparum importin beta, putative 0.0029 0.0057 0.017
Echinococcus granulosus Tubulin alpha 1 chain 0.0264 0.1095 0.6466
Leishmania major beta tubulin 0.0142 0.0555 0.2017
Schistosoma mansoni transient receptor potential channel 0.0065 0.0216 0.1186
Brugia malayi CHE-14 protein 0.0046 0.0129 0.0177
Leishmania major alpha tubulin 0.0264 0.1095 0.4046
Trichomonas vaginalis tubulin beta chain, putative 0.008 0.0282 0.2424
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0022 0.0041
Schistosoma mansoni ran 0.0022 0.0022 0.0021
Leishmania major beta tubulin 0.0142 0.0555 0.2017
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0106 0.0397 0.3497
Toxoplasma gondii alpha tubulin TUBA1 0.0264 0.1095 0.4046
Trichomonas vaginalis tubulin alpha chain, putative 0.008 0.0282 0.2424
Echinococcus granulosus tar DNA binding protein 0.0069 0.0231 0.1278
Echinococcus granulosus TRP transient receptor potential channel 0.0037 0.0089 0.0424
Loa Loa (eye worm) RNA binding protein 0.0069 0.0231 0.1689
Schistosoma mansoni transient receptor potential channel 0.0099 0.0364 0.2077
Loa Loa (eye worm) tubulin beta chain 0.0062 0.02 0.1444
Schistosoma mansoni hypothetical protein 0.0104 0.0387 0.2214
Loa Loa (eye worm) tubulin beta chain 0.0142 0.0555 0.4172
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.004 0.0234
Trypanosoma cruzi tubulin gamma chain 0.0142 0.0555 0.2017
Schistosoma mansoni hypothetical protein 0.0048 0.014 0.0727
Echinococcus granulosus importin subunit beta 1 0.0029 0.0057 0.0228
Schistosoma mansoni tubulin subunit epsilon 0.0142 0.0555 0.3224
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0058
Mycobacterium ulcerans oxidoreductase 0.0021 0.0019 0.0061
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0022 0.0031
Brugia malayi tubulin alpha-2 chain 0.0264 0.1095 0.151
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0152 0.06 0.4517
Schistosoma mansoni hypothetical protein 0.0048 0.014 0.0727
Leishmania major importin beta-1 subunit, putative 0.0024 0.0032 0.005
Leishmania major beta tubulin 0.0142 0.0555 0.2017
Loa Loa (eye worm) hypothetical protein 0.0062 0.0202 0.1459
Echinococcus granulosus GPCR family 2 0.0048 0.014 0.0727
Schistosoma mansoni tyrosine kinase 0.008 0.0281 0.1575
Loa Loa (eye worm) hypothetical protein 0.0034 0.0075 0.0487
Leishmania major beta tubulin 0.0142 0.0555 0.2017
Schistosoma mansoni hypothetical protein 0.0039 0.0099 0.048
Plasmodium vivax delta tubulin, putative 0.0062 0.02 0.0706
Trichomonas vaginalis tubulin beta chain, putative 0.0264 0.1095 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0556 0.323
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0113 0.0355
Trichomonas vaginalis tubulin alpha chain, putative 0.0142 0.0555 0.497
Loa Loa (eye worm) TK/INSR protein kinase 0.0048 0.014 0.0983
Leishmania major alpha tubulin 0.0264 0.1095 0.4046
Leishmania major beta tubulin 0.0142 0.0555 0.2017
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.004 0.0081
Schistosoma mansoni tyrosine kinase 0.0151 0.0593 0.345
Entamoeba histolytica hypothetical protein 0.0039 0.0099 0.0712
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0062 0.02 0.068
Brugia malayi amine oxidase, flavin-containing family protein 0.0021 0.0019 0.0026
Brugia malayi AMP-binding enzyme family protein 0.0026 0.004 0.0055
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0022 0.0021
Brugia malayi hypothetical protein 0.0026 0.004 0.0056
Echinococcus granulosus short transient receptor potential channel 6 0.0065 0.0216 0.1186
Echinococcus granulosus geminin 0.0168 0.0671 0.3919
Trypanosoma cruzi zeta tubulin, putative 0.0062 0.02 0.068
Trypanosoma brucei tubulin gamma chain 0.0142 0.0555 0.2007
Giardia lamblia Beta tubulin 0.0142 0.0555 0.2007
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.1253 0.4642
Echinococcus granulosus tubulin alpha chain 0.0264 0.1095 0.6466
Brugia malayi Protein kinase domain containing protein 0.0048 0.014 0.0192
Entamoeba histolytica tubulin family protein 0.0142 0.0555 0.497
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0019 0.0028
Giardia lamblia Gamma tubulin 0.0142 0.0555 0.2007
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0032 0.005
Trypanosoma brucei epsilon tubulin 0.0142 0.0555 0.2007
Loa Loa (eye worm) hypothetical protein 0.0056 0.0174 0.1248
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.0129 0.066
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0021 0.0019 0.0028
Loa Loa (eye worm) BEN-1 protein 0.0142 0.0555 0.4172
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0022 0.0013
Schistosoma mansoni tubulin subunit alpha 0.0264 0.1095 0.6466
Echinococcus granulosus tubulin alpha chain 0.0264 0.1095 0.6466
Mycobacterium leprae cell division protein FtsZ 0.0062 0.02 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0264 0.1095 0.1445
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.004 0.008
Echinococcus granulosus expressed conserved protein 0.01 0.0369 0.2104
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.004 0.0234
Brugia malayi Transient-receptor-potential like protein 0.0037 0.0089 0.0123
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0048 0.014 0.0162
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0231 0.1278
Loa Loa (eye worm) tubulin beta-4 chain 0.0142 0.0555 0.4172
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0142 0.0556 0.0767
Schistosoma mansoni alpha tubulin 0.0264 0.1095 0.6466
Mycobacterium ulcerans hypothetical protein 0.0158 0.0625 0.5013
Plasmodium vivax tubulin gamma chain, putative 0.0142 0.0555 0.204
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.014 0.0727
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.004 0.0234
Echinococcus granulosus snurportin 1 0.0314 0.1315 0.7792
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0275 0.1144 1
Schistosoma mansoni tubulin subunit beta 0.0142 0.0555 0.3224
Loa Loa (eye worm) hypothetical protein 0.0026 0.004 0.0222
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0142 0.0554 0.2004
Echinococcus multilocularis tubulin subunit beta 0.0142 0.0555 0.0721
Schistosoma mansoni tyrosine kinase 0.008 0.0281 0.1575
Entamoeba histolytica tubulin gamma chain 0.0142 0.0555 0.497
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.02 0.1653
Brugia malayi CXXC zinc finger family protein 0.0028 0.005 0.0069
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0622 0.2678 1
Brugia malayi AMP-binding enzyme family protein 0.0026 0.004 0.0055
Echinococcus multilocularis cpg binding protein 0.0029 0.0057 0.0051
Echinococcus multilocularis tubulin beta 1 chain 0.0142 0.0555 0.0721
Brugia malayi Niemann-Pick C1 protein precursor 0.0106 0.0397 0.0548
Leishmania major telomerase reverse transcriptase, putative 0.0622 0.2678 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0113 0.0355
Trypanosoma brucei alpha tubulin 0.0264 0.1095 0.4038
Leishmania major mitochondrial DNA polymerase beta 0.03 0.1253 0.4642
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0062 0.02 0.5
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.004 0.0234
Loa Loa (eye worm) tubulin alpha chain 0.0264 0.1095 0.8309
Trichomonas vaginalis tubulin beta chain, putative 0.0264 0.1095 1
Trichomonas vaginalis tubulin beta chain, putative 0.0264 0.1095 1
Loa Loa (eye worm) hypothetical protein 0.0264 0.1095 0.8309
Echinococcus multilocularis epidermal growth factor receptor 0.0081 0.0285 0.0357
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0231 0.1278
Loa Loa (eye worm) tubulin alpha-3 chain 0.0184 0.0739 0.5581
Echinococcus granulosus Tubulin beta 2C chain 0.0142 0.0555 0.3224
Echinococcus granulosus tubulin gamma 1 chain 0.0142 0.0555 0.3224
Leishmania major hypothetical protein, conserved 0.0026 0.004 0.0081
Echinococcus granulosus Tubulin beta 2C chain 0.0142 0.0555 0.3224
Echinococcus granulosus tubulin alpha 1C chain 0.0264 0.1095 0.6466
Leishmania major GTP-binding protein, putative 0.0022 0.0022 0.0013
Schistosoma mansoni tyrosine kinase 0.0081 0.0285 0.1597
Echinococcus multilocularis tubulin alpha 3 chain 0.0264 0.1095 0.1445
Brugia malayi Cell division protein ftsZ 0.0062 0.02 0.0275
Chlamydia trachomatis protoporphyrinogen oxidase 0.0021 0.0019 1
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0021 0.0019 0.0061
Giardia lamblia Alpha-tubulin 0.0264 0.1095 0.4038
Mycobacterium tuberculosis Conserved hypothetical protein 0.0158 0.0625 0.544
Schistosoma mansoni tubulin subunit alpha 0.0062 0.02 0.1086
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.02 0.1653
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0058
Leishmania major alpha tubulin 0.0264 0.1095 0.4046
Schistosoma mansoni tubulin subunit beta 0.0142 0.0555 0.3224
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.004 0.117
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0231 0.0286
Echinococcus multilocularis tubulin subunit TubB 0.0264 0.1095 0.1445
Mycobacterium tuberculosis Possible oxidoreductase 0.0021 0.0019 0.0107
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.004 0.0081
Echinococcus granulosus Niemann Pick C1 protein 0.0106 0.0397 0.2275
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0019 0.0028
Loa Loa (eye worm) tubulin alpha 2 0.0202 0.0822 0.6215
Echinococcus multilocularis transient receptor potential ion channel A 0.0096 0.035 0.0445
Loa Loa (eye worm) alpha-tubulin 0.0264 0.1095 0.8309
Echinococcus multilocularis insulin receptor 0.0048 0.014 0.0162
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0062 0.02 0.068
Schistosoma mansoni ran 0.0022 0.0022 0.0021
Trichomonas vaginalis tubulin, putative 0.0142 0.0555 0.497
Onchocerca volvulus 0.0026 0.004 0.0021
Echinococcus granulosus tubulin beta 1 chain 0.0142 0.0555 0.3224
Loa Loa (eye worm) tubulin beta-1 chain 0.0142 0.0555 0.4172

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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