Detailed information for compound 1656952

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 442.51 | Formula: C26H26N4O3
  • H donors: 4 H acceptors: 4 LogP: 3.63 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(c1ccccc1)c1cccc(c1)/C=c/1\[nH]c(=O)/c(=C/c2nc[nH]c2C(C)(C)C)/[nH]c1=O
  • InChi: 1S/C26H26N4O3/c1-26(2,3)23-19(27-15-28-23)14-21-25(33)29-20(24(32)30-21)13-16-8-7-11-18(12-16)22(31)17-9-5-4-6-10-17/h4-15,22,31H,1-3H3,(H,27,28)(H,29,33)(H,30,32)/b20-13-,21-14-
  • InChiKey: JAXFDEUXPHRRCK-NMGXZBPKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0099 0.0137
Trypanosoma cruzi zeta tubulin, putative 0.0064 0.018 0.0459
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0153 0.064 0.0885
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.058 0.3968
Trichomonas vaginalis tubulin epsilon chain, putative 0.0275 0.1267 1
Entamoeba histolytica tubulin alpha-1 chain 0.0275 0.1267 1
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0064 0.0245
Echinococcus granulosus tubulin beta 1 chain 0.0148 0.0612 0.4185
Brugia malayi Niemann-Pick C1 protein precursor 0.0104 0.0388 0.0537
Trichomonas vaginalis tubulin epsilon chain, putative 0.0148 0.0612 0.4482
Schistosoma mansoni tubulin subunit gamma 0.0148 0.0612 0.4185
Giardia lamblia Alpha-tubulin 0.0275 0.1267 0.4451
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0537 0.2622 1
Echinococcus multilocularis beta tubulin 0.0148 0.0612 0.0717
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.058 0.0679
Echinococcus multilocularis peroxisome assembly protein 26 0.0275 0.1267 0.1483
Leishmania major telomerase reverse transcriptase, putative 0.0537 0.2622 1
Leishmania major beta tubulin 0.0148 0.0612 0.2142
Mycobacterium tuberculosis Cell division protein FtsZ 0.0064 0.018 0.0441
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0099 0.0116
Trypanosoma brucei zeta tubulin 0.0064 0.018 0.0687
Trichomonas vaginalis tubulin gamma chain, putative 0.0148 0.0612 0.4482
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0198 0.1354
Schistosoma mansoni tubulin subunit alpha 0.0275 0.1267 0.8663
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0569 0.1979
Echinococcus multilocularis sterol regulatory element binding protein 0.0045 0.008 0.0094
Echinococcus multilocularis Tubulin beta 2C chain 0.0148 0.0612 0.0717
Schistosoma mansoni hypothetical protein 0.0048 0.0099 0.0678
Loa Loa (eye worm) hypothetical protein 0.0105 0.039 0.2664
Trypanosoma brucei beta tubulin 0.0148 0.0612 0.2335
Trypanosoma cruzi UDP-galactopyranose mutase 0.0042 0.0064 0.0005
Trypanosoma brucei beta tubulin 0.0148 0.0612 0.2335
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0537 0.2622 1
Leishmania major beta tubulin 0.0148 0.0612 0.2142
Schistosoma mansoni tubulin subunit alpha 0.0275 0.1267 0.8663
Treponema pallidum cell division protein FtsZ 0.0064 0.018 0.5
Loa Loa (eye worm) hypothetical protein 0.0042 0.0064 0.0439
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0569 0.1975
Echinococcus granulosus beta tubulin 0.0148 0.0612 0.4185
Echinococcus granulosus transient receptor potential ion channel A 0.0095 0.0341 0.233
Trypanosoma cruzi epsilon tubulin, putative 0.0148 0.0612 0.2146
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0142 0.058 0.0803
Leishmania major beta tubulin 0.0148 0.0612 0.2142
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0312 0.1462 1
Leishmania major alpha tubulin 0.0275 0.1267 0.4703
Echinococcus multilocularis Niemann Pick C1 protein 0.0104 0.0388 0.0454
Echinococcus granulosus alpha tubulin 0.0275 0.1267 0.8663
Schistosoma mansoni alpha tubulin 0.0275 0.1267 0.8663
Entamoeba histolytica tubulin family protein 0.0148 0.0612 0.4637
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0042 0.0064 0.0245
Brugia malayi alpha-tubulin 0.0275 0.1267 0.1753
Trichomonas vaginalis tubulin alpha chain, putative 0.0148 0.0612 0.4482
Brugia malayi CHE-14 protein 0.0045 0.008 0.0111
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0099 0.0116
Leishmania major alpha tubulin 0.0275 0.1267 0.4703
Leishmania major beta tubulin 0.0148 0.0612 0.2142
Echinococcus granulosus tubulin alpha chain 0.0275 0.1267 0.8663
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.011 0.0183
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0064 0.018 0.0843
Echinococcus multilocularis tubulin alpha 3 chain 0.0275 0.1267 0.1483
Echinococcus multilocularis tubulin alpha chain 0.0275 0.1267 0.1483
Brugia malayi hypothetical protein 0.0038 0.0046 0.0064
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0042 0.0064 0.0245
Plasmodium vivax telomerase reverse transcriptase, putative 0.0537 0.2622 1
Schistosoma mansoni tubulin subunit alpha 0.0064 0.018 0.1232
Echinococcus multilocularis transient receptor potential ion channel A 0.0095 0.0341 0.0399
Echinococcus granulosus tubulin alpha chain 0.0275 0.1267 0.8663
Loa Loa (eye worm) tubulin beta-4 chain 0.0148 0.0612 0.4185
Trypanosoma brucei telomerase reverse transcriptase 0.0537 0.2622 1
Leishmania major alpha tubulin 0.0275 0.1267 0.4703
Entamoeba histolytica tubulin family protein 0.0148 0.0612 0.4637
Schistosoma mansoni transient receptor potential channel 0.0065 0.0185 0.1268
Trypanosoma cruzi tubulin gamma chain 0.0148 0.0612 0.2146
Echinococcus multilocularis tubulin alpha chain 0.0275 0.1267 0.1483
Leishmania major mitochondrial DNA polymerase beta 0.0295 0.1371 0.511
Loa Loa (eye worm) hypothetical protein 0.0055 0.0132 0.0905
Loa Loa (eye worm) tubulin alpha 2 0.021 0.0935 0.6397
Chlamydia trachomatis protoporphyrinogen oxidase 0.0042 0.0064 0.5
Trichomonas vaginalis tubulin alpha chain, putative 0.0148 0.0612 0.4482
Plasmodium falciparum tubulin gamma chain 0.0148 0.0612 0.2335
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.058 0.3968
Loa Loa (eye worm) alpha-tubulin 0.0275 0.1267 0.8663
Loa Loa (eye worm) tubulin alpha 2 0.0127 0.0504 0.3444
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0064 0.018 0.0687
Echinococcus multilocularis Tubulin beta 2C chain 0.0148 0.0612 0.0717
Loa Loa (eye worm) RNA binding protein 0.0068 0.0198 0.1354
Loa Loa (eye worm) hypothetical protein 0.0037 0.0038 0.026
Loa Loa (eye worm) tubulin alpha 2 0.021 0.0935 0.6397
Mycobacterium ulcerans cell division protein FtsZ 0.0064 0.018 0.0408
Leishmania major beta tubulin 0.0148 0.0612 0.2142
Leishmania major alpha tubulin 0.0275 0.1267 0.4703
Loa Loa (eye worm) hypothetical protein 0.0042 0.0064 0.0439
Mycobacterium ulcerans hypothetical protein 0.0155 0.0651 0.2062
Schistosoma mansoni transient receptor potential channel 4 0.0099 0.0358 0.2446
Loa Loa (eye worm) tubulin beta-2A chain 0.0148 0.0612 0.4185
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0064 0.018 0.5
Schistosoma mansoni tubulin subunit beta 0.0148 0.0612 0.4185
Plasmodium vivax tubulin alpha chain, putative 0.0275 0.1267 0.4833
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0042 0.0064 0.0245
Loa Loa (eye worm) beta-tubulin 0.0148 0.0612 0.4185
Schistosoma mansoni hypothetical protein 0.0312 0.1462 1
Leishmania major beta tubulin 0.0148 0.0612 0.2142
Brugia malayi tubulin alpha-2 chain 0.0275 0.1267 0.1753
Echinococcus multilocularis short transient receptor potential channel 6 0.0065 0.0185 0.0217
Trichomonas vaginalis tubulin beta chain, putative 0.0275 0.1267 1
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0198 0.1354
Toxoplasma gondii RNA-directed DNA polymerase 0.0537 0.2622 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0275 0.1267 0.8663
Trichomonas vaginalis tubulin alpha chain, putative 0.0084 0.0281 0.1689
Giardia lamblia Beta tubulin 0.0148 0.0612 0.1769
Echinococcus granulosus Protein patched homolog 1 0.0045 0.008 0.0549
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.058 0.3968
Leishmania major alpha tubulin 0.0275 0.1267 0.4703
Plasmodium vivax tubulin alpha chain, putative 0.0275 0.1267 0.4833
Echinococcus multilocularis Tubulin alpha 1 chain 0.0275 0.1267 0.1483
Echinococcus multilocularis hypothetical protein 0.0275 0.1267 0.1483
Brugia malayi beta-tubulin, identical 0.0148 0.0612 0.0847
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0106 0.0396 0.2711
Toxoplasma gondii beta tubulin 0.0148 0.0612 0.2335
Echinococcus multilocularis Tubulin beta 2C chain 0.0148 0.0612 0.0717
Leishmania major alpha tubulin 0.0275 0.1267 0.4703
Echinococcus multilocularis tubulin alpha chain 0.0275 0.1267 0.1483
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1683 0.854 1
Trypanosoma brucei epsilon tubulin 0.0148 0.0612 0.2335
Leishmania major zeta tubulin, putative 0.0064 0.018 0.0454
Brugia malayi Telomerase reverse transcriptase 0.1429 0.7227 1
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0037 0.0038 0.0045
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0099 0.0678
Schistosoma mansoni hypothetical protein 0.0048 0.0099 0.0678
Onchocerca volvulus 0.0084 0.0281 0.0218
Echinococcus granulosus tubulin subunit beta 0.0148 0.0612 0.4185
Echinococcus granulosus short transient receptor potential channel 6 0.0065 0.0185 0.1268
Echinococcus multilocularis tubulin subunit beta 0.0148 0.0612 0.0717
Echinococcus multilocularis tubulin beta 1 chain 0.0148 0.0612 0.0717
Trichomonas vaginalis tubulin beta chain, putative 0.0148 0.0612 0.4482
Trichomonas vaginalis tubulin, putative 0.0148 0.0612 0.4482
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0063 0.024
Brugia malayi TAR-binding protein 0.0068 0.0198 0.0274
Loa Loa (eye worm) hypothetical protein 0.0104 0.0388 0.2654
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0148 0.0612 0.0717
Leishmania major beta tubulin 0.0148 0.0612 0.2142
Echinococcus multilocularis tubulin epsilon chain 0.0148 0.0612 0.0717
Trichomonas vaginalis tubulin epsilon chain, putative 0.0148 0.0612 0.4482
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.1371 0.5112
Giardia lamblia Alpha-tubulin 0.0275 0.1267 0.4451
Echinococcus multilocularis tubulin alpha 1C chain 0.0275 0.1267 0.1483
Plasmodium falciparum tubulin beta chain 0.0148 0.0612 0.2335
Schistosoma mansoni hypothetical protein 0.0038 0.0046 0.0314
Brugia malayi Tubulin alpha chain 0.0064 0.018 0.0249
Brugia malayi Tubulin alpha-2 chain 0.0275 0.1267 0.1753
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0099 0.0678
Leishmania major beta tubulin 0.0148 0.0612 0.2142
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0198 0.1354
Echinococcus granulosus tubulin delta chain 0.0064 0.018 0.1232
Trichomonas vaginalis tubulin beta chain, putative 0.0275 0.1267 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0148 0.0612 0.2335
Schistosoma mansoni amine oxidase 0.0042 0.0064 0.0439
Schistosoma mansoni tubulin subunit beta 0.0148 0.0612 0.4185
Trypanosoma brucei alpha tubulin, putative 0.0084 0.0281 0.1071
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0104 0.0388 0.2802
Schistosoma mansoni tubulin subunit alpha 0.0275 0.1267 0.8663
Mycobacterium leprae cell division protein FtsZ 0.0064 0.018 1
Schistosoma mansoni hypothetical protein 0.0043 0.0072 0.0492
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.058 0.3968
Plasmodium falciparum alpha tubulin 2 0.0275 0.1267 0.4833
Loa Loa (eye worm) hypothetical protein 0.0275 0.1267 0.8663
Schistosoma mansoni hypothetical protein 0.0105 0.039 0.2664
Echinococcus granulosus lysine specific histone demethylase 1A 0.0042 0.0064 0.0439
Schistosoma mansoni tubulin subunit beta 0.0148 0.0612 0.4185
Toxoplasma gondii histone lysine-specific demethylase 0.0042 0.0064 0.0245
Trypanosoma cruzi tubulin delta chain 0.0064 0.018 0.0459
Echinococcus granulosus tubulin alpha 0.0148 0.0612 0.4185
Echinococcus multilocularis Niemann Pick C1 protein 0.0149 0.0619 0.0725
Trypanosoma brucei alpha tubulin 0.0275 0.1267 0.4833
Leishmania major alpha tubulin 0.0275 0.1267 0.4703
Echinococcus granulosus tubulin alpha chain 0.0275 0.1267 0.8663
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0198 0.1354
Brugia malayi Tubulin gamma chain 0.0148 0.0612 0.0847
Echinococcus granulosus Tubulin alpha 1 chain 0.0275 0.1267 0.8663
Plasmodium falciparum alpha tubulin 1 0.0275 0.1267 0.4833
Loa Loa (eye worm) tubulin alpha chain 0.0275 0.1267 0.8663
Schistosoma mansoni alpha tubulin 0.0275 0.1267 0.8663
Trypanosoma brucei beta tubulin 0.0148 0.0612 0.2335
Brugia malayi Tubulin beta chain 0.0084 0.0281 0.0388
Trichomonas vaginalis tubulin beta chain, putative 0.0275 0.1267 1
Toxoplasma gondii alpha-tubulin I, putative 0.0275 0.1267 0.4833
Leishmania major alpha tubulin 0.0275 0.1267 0.4703
Leishmania major beta tubulin 0.0148 0.0612 0.2142
Schistosoma mansoni tubulin subunit beta 0.0148 0.0612 0.4185
Plasmodium falciparum tubulin epsilon chain, putative 0.0148 0.0612 0.2335
Brugia malayi RNA, U transporter 1 0.0083 0.0279 0.0386
Schistosoma mansoni amine oxidase 0.0042 0.0064 0.0439
Echinococcus granulosus Tubulin beta 2C chain 0.0148 0.0612 0.4185
Giardia lamblia Beta tubulin 0.0148 0.0612 0.1769
Echinococcus multilocularis Tubulin alpha 1 chain 0.0275 0.1267 0.1483
Toxoplasma gondii hypothetical protein 0.0048 0.0094 0.036
Loa Loa (eye worm) alpha-tubulin 0.0275 0.1267 0.8663
Echinococcus multilocularis snurportin 1 0.0312 0.1462 0.1712
Echinococcus granulosus Tubulin alpha 1 chain 0.0275 0.1267 0.8663
Echinococcus granulosus peroxisome assembly protein 26 0.0275 0.1267 0.8663
Loa Loa (eye worm) hypothetical protein 0.021 0.0935 0.6397
Trichomonas vaginalis tubulin beta chain, putative 0.0275 0.1267 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0191 0.0835 0.6361
Loa Loa (eye worm) hypothetical protein 0.0042 0.0064 0.0439
Trichomonas vaginalis tubulin alpha chain, putative 0.0084 0.0281 0.1689
Leishmania major gamma-tubulin 0.0148 0.0612 0.2142
Echinococcus granulosus short transient receptor potential channel 6 0.0065 0.0185 0.1268
Echinococcus granulosus tubulin epsilon chain 0.0148 0.0612 0.4185
Echinococcus multilocularis tubulin gamma 1 chain 0.0148 0.0612 0.0717
Trypanosoma brucei epsilon tubulin 0.0148 0.0612 0.2335
Toxoplasma gondii beta-tubulin, putative 0.0148 0.0612 0.2335
Echinococcus multilocularis tubulin delta chain 0.0064 0.018 0.0211
Loa Loa (eye worm) tubulin alpha chain 0.0275 0.1267 0.8663
Echinococcus multilocularis transient receptor potential gamma protein 0.0099 0.0358 0.0419
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0042 0.0064 0.0075
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0042 0.0064 0.0439
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0592 0.2907 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0099 0.0678
Echinococcus granulosus sterol regulatory element binding protein 0.0045 0.008 0.0549
Schistosoma mansoni hypothetical protein 0.0048 0.0099 0.0678
Loa Loa (eye worm) tubulin beta-1 chain 0.0148 0.0612 0.4185
Leishmania major alpha tubulin 0.0275 0.1267 0.4703
Echinococcus granulosus GPCR family 2 0.0048 0.0099 0.0678
Loa Loa (eye worm) alpha-tubulin isotype 2 0.021 0.0935 0.6397
Plasmodium vivax delta tubulin, putative 0.0064 0.018 0.0687
Brugia malayi hypothetical protein 0.0042 0.0064 0.0089
Leishmania major beta tubulin 0.0148 0.0612 0.2142
Loa Loa (eye worm) hypothetical protein 0.0191 0.0835 0.571
Echinococcus multilocularis tubulin alpha chain 0.0275 0.1267 0.1483
Echinococcus granulosus tubulin alpha 1C chain 0.0275 0.1267 0.8663
Echinococcus multilocularis Tubulin beta 2C chain 0.0148 0.0612 0.0717
Echinococcus multilocularis protein dispatched 1 0.0051 0.0113 0.0132
Trypanosoma cruzi zeta tubulin, putative 0.0064 0.018 0.0459
Trypanosoma brucei tubulin delta chain 0.0064 0.018 0.0687
Echinococcus granulosus tubulin alpha 3 chain 0.0275 0.1267 0.8663
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0198 0.1354
Echinococcus granulosus transient receptor potential gamma protein 0.0099 0.0358 0.2446
Leishmania major epsilon tubulin, putative 0.0148 0.0612 0.2142
Echinococcus granulosus tar DNA binding protein 0.0068 0.0198 0.1354
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0084 0.0281 0.1689
Toxoplasma gondii beta-1 tubulin, putative 0.0148 0.0612 0.2335
Plasmodium falciparum tubulin delta chain, putative 0.0064 0.018 0.0687
Trichomonas vaginalis tubulin, putative 0.0084 0.0281 0.1689
Leishmania major beta tubulin 0.0148 0.0612 0.2142
Schistosoma mansoni transient receptor potential channel 0.0099 0.0358 0.2446
Echinococcus multilocularis 0.0042 0.0064 0.0075
Trichomonas vaginalis tubulin gamma chain, putative 0.0064 0.018 0.0843
Loa Loa (eye worm) BEN-1 protein 0.0148 0.0612 0.4185
Giardia lamblia Gamma tubulin 0.0148 0.0612 0.1769
Echinococcus multilocularis short transient receptor potential channel 6 0.0065 0.0185 0.0217
Brugia malayi Calcitonin receptor-like protein seb-1 0.0153 0.064 0.0885
Echinococcus multilocularis beta tubulin 0.0148 0.0612 0.0717
Plasmodium vivax tubulin gamma chain, putative 0.0148 0.0612 0.2335
Loa Loa (eye worm) hypothetical protein 0.0042 0.0064 0.0439
Trichomonas vaginalis tubulin, putative 0.0084 0.0281 0.1689
Plasmodium vivax tubulin epsilon chain, putative 0.0148 0.0612 0.2335
Leishmania major beta tubulin 0.0148 0.0612 0.2142
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0046 0.0314
Trichomonas vaginalis tubulin epsilon chain, putative 0.0064 0.018 0.0843
Leishmania major beta tubulin 0.0148 0.0612 0.2142
Giardia lamblia Telomerase catalytic subunit 0.0537 0.2622 1
Schistosoma mansoni patched 1 0.0045 0.008 0.0549
Echinococcus granulosus beta tubulin 0.0148 0.0612 0.4185
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0142 0.058 0.3968
Echinococcus granulosus Tubulin beta 2C chain 0.0148 0.0612 0.4185
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.0651 0.2231
Trypanosoma brucei alpha tubulin 0.0275 0.1267 0.4833
Trypanosoma brucei epsilon tubulin 0.0148 0.0612 0.2335
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0198 0.1354
Brugia malayi Tubulin alpha chain 0.0275 0.1267 0.1753
Echinococcus granulosus Niemann Pick C1 protein 0.0104 0.0388 0.2654
Trypanosoma cruzi UDP-galactopyranose mutase 0.0042 0.0064 0.0005
Plasmodium falciparum telomerase reverse transcriptase 0.0537 0.2622 1
Echinococcus multilocularis tubulin subunit TubB 0.0275 0.1267 0.1483
Loa Loa (eye worm) tubulin alpha-3 chain 0.0191 0.0835 0.571
Echinococcus granulosus tubulin alpha chain 0.0275 0.1267 0.8663
Echinococcus granulosus tubulin alpha chain 0.0275 0.1267 0.8663
Brugia malayi Transient-receptor-potential like protein 0.0037 0.0038 0.0053
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0064 0.018 0.0687
Brugia malayi Tubulin alpha-2 chain 0.0275 0.1267 0.1753
Loa Loa (eye worm) hypothetical protein 0.0062 0.0168 0.1152
Echinococcus granulosus lysine specific histone demethylase 1A 0.0042 0.0064 0.0439
Loa Loa (eye worm) hypothetical protein 0.0045 0.008 0.0549
Brugia malayi Tubulin beta-1 chain 0.0148 0.0612 0.0847
Plasmodium falciparum protoporphyrinogen oxidase 0.0042 0.0064 0.0245
Trichomonas vaginalis tubulin beta chain, putative 0.0084 0.0281 0.1689
Trypanosoma brucei beta tubulin 0.0148 0.0612 0.2335
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0046 0.0314
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0042 0.0064 0.0245
Trichomonas vaginalis tubulin gamma chain, putative 0.0148 0.0612 0.4482
Echinococcus granulosus tubulin beta 4A class IVa 0.0148 0.0612 0.4185
Loa Loa (eye worm) hypothetical protein 0.0042 0.0064 0.0439
Echinococcus multilocularis protoporphyrinogen oxidase 0.0042 0.0064 0.0075
Schistosoma mansoni hypothetical protein 0.0048 0.0099 0.0678
Brugia malayi amine oxidase, flavin-containing family protein 0.0042 0.0064 0.0089
Leishmania major alpha tubulin 0.0275 0.1267 0.4703
Leishmania major beta tubulin 0.0148 0.0612 0.2142
Schistosoma mansoni alpha tubulin 0.0275 0.1267 0.8663
Echinococcus granulosus snurportin 1 0.0312 0.1462 1
Echinococcus granulosus Tubulin beta 2C chain 0.0148 0.0612 0.4185
Schistosoma mansoni tubulin subunit beta 0.0148 0.0612 0.4185
Schistosoma mansoni hypothetical protein 0.0043 0.0072 0.0492
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0198 0.0232
Schistosoma mansoni tubulin subunit epsilon 0.0148 0.0612 0.4185
Echinococcus granulosus tubulin gamma 1 chain 0.0148 0.0612 0.4185
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.058 0.3968
Leishmania major beta tubulin 0.0148 0.0612 0.2142
Trichomonas vaginalis tubulin beta chain, putative 0.0275 0.1267 1
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0592 0.2907 1
Echinococcus granulosus Tubulin beta 2C chain 0.0148 0.0612 0.4185
Echinococcus granulosus expressed conserved protein 0.0098 0.0355 0.243
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0551 0.2692 1
Loa Loa (eye worm) tubulin beta chain 0.0064 0.018 0.1232
Loa Loa (eye worm) hypothetical protein 0.0153 0.064 0.4375
Trypanosoma brucei tubulin gamma chain 0.0148 0.0612 0.2335
Leishmania major delta tubulin, putative 0.0064 0.018 0.0454
Trichomonas vaginalis tubulin epsilon chain, putative 0.0275 0.1267 1
Echinococcus granulosus tubulin alpha 1C chain 0.0275 0.1267 0.8663
Brugia malayi RNA binding protein 0.0068 0.0198 0.0274
Echinococcus multilocularis tubulin alpha 3 chain 0.0275 0.1267 0.1483
Brugia malayi tubulin alpha chain - mouse 0.0275 0.1267 0.1753
Trichomonas vaginalis tubulin, putative 0.0064 0.018 0.0843
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.1371 0.5112
Echinococcus multilocularis tubulin alpha 1C chain 0.0275 0.1267 0.1483
Echinococcus granulosus TRP transient receptor potential channel 0.0037 0.0038 0.026
Echinococcus granulosus tubulin alpha 3 chain 0.0275 0.1267 0.8663
Echinococcus multilocularis GPCR, family 2 0.0048 0.0099 0.0116
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0198 0.0274
Echinococcus multilocularis tubulin alpha chain 0.0275 0.1267 0.1483
Entamoeba histolytica tubulin alpha chain, putative 0.0275 0.1267 1
Trypanosoma brucei beta tubulin 0.0148 0.0612 0.2335
Plasmodium vivax tubulin beta chain, putative 0.0148 0.0612 0.2335
Loa Loa (eye worm) tubulin gamma chain 0.0148 0.0612 0.4185
Leishmania major alpha tubulin 0.0275 0.1267 0.4703
Trypanosoma brucei zeta tubulin, putative 0.0064 0.018 0.0687
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.018 0.0843
Echinococcus granulosus Niemann Pick C1 protein 0.0149 0.0619 0.4236
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.021 0.0935 0.7207
Echinococcus multilocularis expressed conserved protein 0.0098 0.0355 0.0416
Echinococcus multilocularis Tubulin alpha 1 chain 0.0275 0.1267 0.1483
Trypanosoma cruzi tubulin delta chain 0.0064 0.018 0.0459
Entamoeba histolytica tubulin gamma chain 0.0148 0.0612 0.4637
Loa Loa (eye worm) tubulin beta chain 0.0148 0.0612 0.4185
Echinococcus multilocularis Tubulin beta 2C chain 0.0148 0.0612 0.0717
Brugia malayi Cell division protein ftsZ 0.0064 0.018 0.0249
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0042 0.0064 0.0439
Trichomonas vaginalis tubulin beta chain, putative 0.0275 0.1267 1
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0198 0.1354
Leishmania major beta tubulin 0.0148 0.0612 0.2142
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.018 0.0843
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0064 0.0245
Echinococcus multilocularis tubulin alpha 0.0148 0.0612 0.0717
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0275 0.1267 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0046 0.0054
Brugia malayi latrophilin 2 splice variant baaae 0.0105 0.039 0.0539
Trypanosoma cruzi alpha tubulin, putative 0.0275 0.1267 0.4706
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0099 0.0137
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.0569 0.2171
Schistosoma mansoni transient receptor potential channel 0.0065 0.0185 0.1268
Schistosoma mansoni hypothetical protein 0.0043 0.0072 0.0492
Echinococcus granulosus Tubulin beta 2C chain 0.0148 0.0612 0.4185
Trypanosoma cruzi epsilon tubulin, putative 0.0148 0.0612 0.2146
Brugia malayi SWIRM domain containing protein 0.0042 0.0064 0.0089
Trypanosoma brucei alpha tubulin 0.0275 0.1267 0.4833
Loa Loa (eye worm) BEN-1 protein 0.0148 0.0612 0.4185
Schistosoma mansoni tubulin subunit delta 0.0064 0.018 0.1232
Loa Loa (eye worm) hypothetical protein 0.0033 0.0021 0.0144
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0045 0.008 0.0549
Echinococcus granulosus tubulin subunit TubB 0.0275 0.1267 0.8663
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0295 0.1371 0.523
Schistosoma mansoni tubulin subunit beta 0.0148 0.0612 0.4185
Brugia malayi Tubulin beta chain 0.0064 0.018 0.0249
Trypanosoma cruzi beta tubulin, putative 0.0148 0.0612 0.2146
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0153 0.064 0.4375
Trichomonas vaginalis tubulin gamma chain, putative 0.0148 0.0612 0.4482
Echinococcus multilocularis protein patched 0.0045 0.008 0.0094
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0042 0.0064 0.0245
Loa Loa (eye worm) hypothetical protein 0.0099 0.0358 0.2446
Leishmania major beta tubulin 0.0148 0.0612 0.2142
Leishmania major beta tubulin 0.0148 0.0612 0.2142
Loa Loa (eye worm) hypothetical protein 0.0042 0.0064 0.0439
Trichomonas vaginalis tubulin alpha chain, putative 0.0084 0.0281 0.1689
Leishmania major alpha tubulin 0.0275 0.1267 0.4703
Loa Loa (eye worm) hypothetical protein 0.0048 0.0099 0.0678
Trypanosoma brucei alpha tubulin 0.0275 0.1267 0.4833
Loa Loa (eye worm) tubulin alpha-2 chain 0.0275 0.1267 0.8663
Toxoplasma gondii alpha tubulin TUBA1 0.0275 0.1267 0.4833
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.058 0.0679
Giardia lamblia Beta tubulin 0.0148 0.0612 0.1769
Schistosoma mansoni tubulin subunit beta 0.0064 0.018 0.1232
Schistosoma mansoni hypothetical protein 0.0043 0.0072 0.0492

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 41 nM Cytotoxicity against human HT-29 cells after 48 hrs by XTT assay ChEMBL. 22727370

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 22727370

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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