TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 443.494 | Formula: C26H25N3O4
H donors: 3 H acceptors: 4 LogP: 5.01 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)COc1cc(C)c(c(c1)C)c1nc2c([nH]1)cc(cc2)C(=O)Nc1ccc(c(c1)C)C
InChi: 1S/C26H25N3O4/c1-14-5-7-19(9-15(14)2)27-26(32)18-6-8-21-22(12-18)29-25(28-21)24-16(3)10-20(11-17(24)4)33-13-23(30)31/h5-12H,13H2,1-4H3,(H,27,32)(H,28,29)(H,30,31)
InChiKey: SNTCIFKVANLNAU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	diacylglycerol O-acyltransferase 1	Starlite/ChEMBL	References
Mus musculus	diacylglycerol O-acyltransferase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	diacylglycerol O acyltransferase 1	Get druggable targets OG5_128200	All targets in OG5_128200
Neospora caninum	diacylglycerol acyltransferase, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Cryptosporidium hominis	acyl-CoA:diacylglycerol acyltransferase 1-related enzyme	Get druggable targets OG5_128200	All targets in OG5_128200
Candida albicans	Acyl-CoA cholesterol acyltransferase	Get druggable targets OG5_128200	All targets in OG5_128200
Neospora caninum	sterol O-acyltransferase, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Schistosoma japonicum	Diacylglycerol O-acyltransferase 1, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	Get druggable targets OG5_128200	All targets in OG5_128200
Schistosoma japonicum	Diacylglycerol O-acyltransferase 1, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Toxoplasma gondii	acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha	Get druggable targets OG5_128200	All targets in OG5_128200
Candida albicans	Acyl-CoA cholesterol acyltransferase	Get druggable targets OG5_128200	All targets in OG5_128200
Echinococcus multilocularis	diacylglycerol O acyltransferase 1	Get druggable targets OG5_128200	All targets in OG5_128200
Schistosoma japonicum	ko:K00635 diacylglycerol O-acyltransferase [EC2.3.1.20], putative	Get druggable targets OG5_128200	All targets in OG5_128200
Plasmodium yoelii	acyl transferase-related	Get druggable targets OG5_128200	All targets in OG5_128200
Theileria parva	diacylglycerol O-acyltransferase, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Babesia bovis	diacylglycerol acyltransferase, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Cryptosporidium parvum	diacylglycerol acyltransferase 1	Get druggable targets OG5_128200	All targets in OG5_128200
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128200	All targets in OG5_128200
Plasmodium falciparum	diacylglycerol O-acyltransferase	Get druggable targets OG5_128200	All targets in OG5_128200
Brugia malayi	diacylglycerol acyltransferase	Get druggable targets OG5_128200	All targets in OG5_128200
Loa Loa (eye worm)	diacylglycerol acyltransferase	Get druggable targets OG5_128200	All targets in OG5_128200
Plasmodium knowlesi	diacylglycerol O-acyltransferase, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Plasmodium vivax	diacylglycerol O-acyltransferase, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Plasmodium berghei	diacylglycerol O-acyltransferase, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Toxoplasma gondii	acyl-CoA:diacylglycerol acyltransferase 1-related enzyme	Get druggable targets OG5_128200	All targets in OG5_128200

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	hypothetical protein	0.0077	0.0576	1
Leishmania major	DNA polymerase kappa, putative	0.0014	0.0038	0.075
Trypanosoma cruzi	glycerol uptake protein, putative	0.0052	0.036	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0038	0.1054
Echinococcus multilocularis	dna polymerase kappa	0.0014	0.0038	0.0022
Loa Loa (eye worm)	hhat protein	0.0052	0.036	0.1353
Brugia malayi	MH2 domain containing protein	0.0077	0.0576	0.2212
Loa Loa (eye worm)	transcription factor SMAD2	0.0077	0.0576	0.22
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0037	0.0235	0.5856
Schistosoma mansoni	hypothetical protein	0.0166	0.135	0.2198
Brugia malayi	MBOAT family protein	0.0052	0.036	0.1367
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0243	0.2014	0.7853
Brugia malayi	MBOAT family protein	0.0052	0.036	0.1367
Plasmodium vivax	importin-beta 2, putative	0.002	0.0085	0.0273
Brugia malayi	TAR-binding protein	0.0088	0.0676	0.2606
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0077	0.0579	0.0927
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0014	0.0041	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0014	0.0038	0.1054
Echinococcus multilocularis	geminin	0.0717	0.6098	0.6092
Mycobacterium tuberculosis	Polyketide synthetase MbtD (polyketide synthase)	0.0011	0.0014	0.0052
Brugia malayi	hypothetical protein	0.0023	0.0118	0.0416
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0052	0.036	0.0566
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0012	0.0016	0.0438
Echinococcus granulosus	snurportin 1	0.021	0.1728	0.2815
Brugia malayi	MBOAT family protein	0.0052	0.036	0.1367
Trypanosoma brucei	unspecified product	0.0014	0.0038	0.1054
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0038	0.1054
Loa Loa (eye worm)	hypothetical protein	0.002	0.0085	0.0273
Mycobacterium tuberculosis	Probable thioesterase TesA	0.0031	0.0182	0.4459
Trypanosoma cruzi	glycerol uptake protein, putative	0.0052	0.036	1
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0016	0.0056	0.0066
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0052	0.036	0.0566
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0038	0.1054
Mycobacterium tuberculosis	Probable polyketide synthase Pks8	0.003	0.0177	0.4329
Loa Loa (eye worm)	MBOAT family protein	0.0052	0.036	0.1353
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.021	0.1728	0.6727
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0035	0.0214	0.5305
Loa Loa (eye worm)	hypothetical protein	0.0052	0.036	0.1353
Toxoplasma gondii	LsmAD domain-containing protein	0.0036	0.0229	0.0838
Loa Loa (eye worm)	RNA binding protein	0.0088	0.0676	0.2595
Leishmania major	glycerol uptake protein, putative	0.0052	0.036	1
Schistosoma mansoni	transcription factor LCR-F1	0.0077	0.0576	0.0926
Echinococcus granulosus	dna polymerase eta	0.0014	0.0038	0.0036
Schistosoma mansoni	membrane-bound acyltransferase/hhat	0.0052	0.036	0.0572
Schistosoma mansoni	ran	0.0014	0.0041	0.0047
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0031	0.0185	0.0284
Trypanosoma cruzi	glycerol uptake protein, putative	0.0052	0.036	1
Loa Loa (eye worm)	diacylglycerol acyltransferase	0.0307	0.2561	1
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0037	0.0235	0.5856
Brugia malayi	Hhat protein	0.0052	0.036	0.1367
Trypanosoma cruzi	PAB1-binding protein , putative	0.0036	0.0229	0.6189
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0037	0.0235	0.5856
Mycobacterium tuberculosis	Probable membrane bound polyketide synthase Pks6	0.0055	0.0393	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0038	0.1054
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0014	0.0038	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0052	0.036	0.1353
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0077	0.0579	0.2227
Brugia malayi	MBOAT family protein	0.0052	0.036	0.1367
Brugia malayi	latrophilin 2 splice variant baaae	0.0166	0.135	0.5249
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0014	0.0038	0.0087
Echinococcus granulosus	geminin	0.0717	0.6098	1
Schistosoma mansoni	DNA polymerase eta	0.0014	0.0038	0.0043
Echinococcus granulosus	diacylglycerol O acyltransferase 1	0.0307	0.2561	0.4185
Echinococcus granulosus	dna polymerase kappa	0.0014	0.0038	0.0036
Trypanosoma brucei	glycerol uptake protein, putative	0.0052	0.036	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0077	0.0576	0.0561
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0014	0.0038	0.0685
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0077	0.0579	0.0565
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0014	0.0041	0.0041
Toxoplasma gondii	HEAT repeat-containing protein	0.002	0.0085	0.0273
Mycobacterium leprae	Probable polyketide synthase Pks1	0.0039	0.0255	0.6337
Brugia malayi	ImpB/MucB/SamB family protein	0.0014	0.0038	0.0102
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0037	0.0235	0.5834
Schistosoma mansoni	tar DNA-binding protein	0.0088	0.0676	0.1092
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0012	0.0016	0.0103
Mycobacterium leprae	Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas	0.0039	0.0255	0.6337
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsB	0.003	0.0173	0.4188
Trypanosoma brucei	DNA polymerase eta, putative	0.0014	0.0038	0.1054
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0014	0.0041	0.0097
Schistosoma mansoni	hypothetical protein	0.0016	0.0056	0.0073
Entamoeba histolytica	Ran family GTPase	0.0014	0.0041	0.0048
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0037	0.0235	0.5834
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0014	0.0041	0.0097
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD	0.0037	0.0235	0.581
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	0.007	0.0521	0.1998
Schistosoma mansoni	sterol O-acyltransferase 1	0.0052	0.036	0.0572
Leishmania major	importin beta-1 subunit, putative	0.0016	0.0053	0.1189
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0052	0.036	0.5994
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0031	0.0185	0.0665
Brugia malayi	Importin beta-1 subunit	0.002	0.0085	0.0289
Mycobacterium leprae	PROBABLE THIOESTERASE TESA	0.0031	0.0182	0.4398
Schistosoma mansoni	tar DNA-binding protein	0.0088	0.0676	0.1092
Loa Loa (eye worm)	hypothetical protein	0.0166	0.135	0.5241
Brugia malayi	hypothetical protein	0.0036	0.0229	0.0852
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0077	0.0579	0.0927
Loa Loa (eye worm)	hypothetical protein	0.0052	0.036	0.1353
Echinococcus multilocularis	GPCR, family 2	0.0077	0.0579	0.0565
Trichomonas vaginalis	conserved hypothetical protein	0.0052	0.036	1
Brugia malayi	MBOAT family protein	0.0052	0.036	0.1367
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0052	0.036	0.0572
Onchocerca volvulus		0.0107	0.0836	0.7041
Echinococcus granulosus	membrane bound acyltransferase:hhat	0.0052	0.036	0.0566
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0019	0.0077	0.0241
Echinococcus granulosus	protein cysteine N palmitoyltransferase	0.0052	0.036	0.0566
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0014	0.0038	0.0685
Mycobacterium tuberculosis	Polyketide synthase Pks13	0.0055	0.0393	1
Echinococcus granulosus	tar DNA binding protein	0.0088	0.0676	0.1086
Brugia malayi	RNA binding protein	0.0088	0.0676	0.2606
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE	0.0024	0.0127	0.2941
Echinococcus multilocularis	importin subunit beta 1	0.002	0.0085	0.007
Echinococcus multilocularis	sterol O acyltransferase 1	0.0052	0.036	0.0345
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0031	0.0185	0.0284
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	0.0307	0.2561	0.4189
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0016	0.0053	0.1089
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0052	0.036	0.5994
Mycobacterium tuberculosis	Polyketide synthase Pks2	0.0036	0.0225	0.5599
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0035	0.0214	0.0779
Onchocerca volvulus	Fatty acid synthase homolog	0.0067	0.0491	0.3139
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0077	0.0579	0.2215
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0038	0.1054
Mycobacterium ulcerans	thioesterase	0.0031	0.0182	0.443
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0052	0.036	0.0345
Plasmodium falciparum	diacylglycerol O-acyltransferase	0.0307	0.2561	1
Schistosoma mansoni	hypothetical protein	0.0077	0.0579	0.0933
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0038	0.1054
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0052	0.036	0.5994
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0095	0.031
Echinococcus multilocularis	dna polymerase eta	0.0014	0.0038	0.0022
Entamoeba histolytica	hypothetical protein, conserved	0.0052	0.036	0.5994
Leishmania major	GTP-binding protein, putative	0.0014	0.0041	0.0824
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB	0.003	0.0173	0.4155
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0014	0.0038	0.0644
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0037	0.0235	0.5834
Brugia malayi	N-terminal motif family protein	0.0137	0.1098	0.4259
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0052	0.036	0.0572
Mycobacterium ulcerans	polyketide synthase	0.0039	0.0255	0.6357
Brugia malayi	isocitrate dehydrogenase	0.0012	0.0016	0.0015
Mycobacterium ulcerans	thioesterase TesA	0.0031	0.0182	0.443
Brugia malayi	AMP-binding enzyme family protein	0.0035	0.0214	0.0793
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0836	0.3223
Schistosoma mansoni	tar DNA-binding protein	0.0088	0.0676	0.1092
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0014	0.0041	0.0097
Toxoplasma gondii	type I fatty acid synthase, putative	0.0026	0.0143	0.05
Echinococcus multilocularis	lysophospholipid acyltransferase 7	0.0052	0.036	0.0345
Mycobacterium tuberculosis	Probable fatty acid synthase Fas (fatty acid synthetase)	0.0012	0.0016	0.0108
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0014	0.0038	0.0644
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0229	0.0838
Brugia malayi	Latrophilin receptor protein 2	0.0077	0.0579	0.2227
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0031	0.0185	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0052	0.036	0.1353
Schistosoma mansoni	hypothetical protein	0.0717	0.6098	1
Schistosoma mansoni	ran	0.0014	0.0041	0.0047
Mycobacterium ulcerans	polyketide synthase Pks13	0.0055	0.0393	1
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0014	0.0041	0.0025
Mycobacterium leprae	Polyketide synthase Pks13	0.0055	0.0393	1
Mycobacterium ulcerans	DNA polymerase IV	0.0014	0.0038	0.0637
Entamoeba histolytica	hypothetical protein	0.0077	0.0576	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0077	0.0579	0.0565
Trypanosoma cruzi	DNA polymerase eta, putative	0.0014	0.0038	0.0644
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0077	0.0576	0.0921
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0014	0.0041	0.0113
Trypanosoma brucei	DNA polymerase IV, putative	0.0014	0.0038	0.1054
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0014	0.0038	0.075
Echinococcus granulosus	lysophospholipid acyltransferase 7	0.0052	0.036	0.0566
Trypanosoma brucei	importin beta-1 subunit, putative	0.002	0.0085	0.237
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA	0.0037	0.0235	0.581
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0012	0.0016	0.0438
Echinococcus granulosus	Membrane bound O acyl transferase MBOAT	0.0052	0.036	0.0566
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0088	0.0676	0.2595
Schistosoma mansoni	zinc finger protein	0.0052	0.036	0.0572
Echinococcus multilocularis	membrane bound acyltransferase:hhat	0.0052	0.036	0.0345
Mycobacterium tuberculosis	Probable multifunctional mycocerosic acid synthase membrane-associated Mas	0.0039	0.0255	0.6376
Entamoeba histolytica	hypothetical protein	0.0077	0.0576	1
Mycobacterium tuberculosis	Probable polyketide synthase Pks9	0.0021	0.0097	0.224
Schistosoma mansoni	leukocyte receptor cluster (lrc) member 4 protein	0.0052	0.036	0.0572
Trichomonas vaginalis	porcupine, putative	0.0052	0.036	1
Mycobacterium tuberculosis	Probable polyketide synthase Pks15	0.0015	0.0045	0.0864
Leishmania major	hypothetical protein, conserved	0.0052	0.036	1
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0016	0.0053	0.1189
Trypanosoma brucei	PAB1-binding protein , putative	0.0036	0.0229	0.6356
Echinococcus multilocularis	tar DNA binding protein	0.0088	0.0676	0.0661
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0014	0.0038	0.0022
Brugia malayi	hypothetical protein	0.0107	0.0836	0.3234
Toxoplasma gondii	beta-ketoacyl synthase, N-terminal domain-containing protein	0.0024	0.0123	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0243	0.2014	0.7849
Loa Loa (eye worm)	MBOAT family protein	0.0052	0.036	0.1353
Schistosoma mansoni	tar DNA-binding protein	0.0088	0.0676	0.1092
Trichomonas vaginalis	conserved hypothetical protein	0.0052	0.036	1
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0052	0.036	0.0566
Brugia malayi	ImpB/MucB/SamB family protein	0.0014	0.0038	0.0102
Entamoeba histolytica	vacuolar protein sorting 26	0.0052	0.036	0.5994
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0038	0.1054
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0014	0.0041	0.1126
Mycobacterium tuberculosis	Probable polyketide synthase Pks1	0.0027	0.0145	0.3495
Plasmodium vivax	ataxin-2 like protein, putative	0.0036	0.0229	0.0838
Mycobacterium ulcerans	multifunctional mycocerosic acid synthase membrane-associated Mas	0.0039	0.0255	0.6357
Echinococcus multilocularis	snurportin 1	0.021	0.1728	0.1715
Onchocerca volvulus		0.0052	0.036	0.1655
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsE	0.0024	0.0127	0.2981
Brugia malayi	RNA recognition motif domain containing protein	0.0088	0.0676	0.2606
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0137	0.1098	1
Entamoeba histolytica	hypothetical protein	0.0052	0.036	0.5994
Onchocerca volvulus		0.0064	0.0472	0.2915
Treponema pallidum	alginate O-acetylation protein (algI)	0.0052	0.036	0.5
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0037	0.0235	0.5834
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	0.0037	0.0235	0.0876
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0243	0.2014	0.7849
Entamoeba histolytica	hypothetical protein	0.0016	0.0053	0.0285
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0031	0.0185	0.0278
Mycobacterium tuberculosis	Polyketide synthase Pks12	0.0039	0.0255	0.6376
Trypanosoma cruzi	GUP1, putative	0.0052	0.036	1
Trypanosoma cruzi	GUP1, putative	0.0052	0.036	1
Toxoplasma gondii	acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha	0.0307	0.2561	1
Schistosoma mansoni	hypothetical protein	0.0077	0.0579	0.0933
Toxoplasma gondii	hypothetical protein	0.0052	0.036	0.1353
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0012	0.0016	0.0113
Leishmania major	glycerol uptake protein, putative	0.0052	0.036	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0038	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0452	0.1715
Trichomonas vaginalis	ran, putative	0.0014	0.0041	0.0824
Schistosoma mansoni	importin beta-1	0.002	0.0085	0.0121
Mycobacterium ulcerans	DNA polymerase IV	0.0014	0.0038	0.0637
Trichomonas vaginalis	conserved hypothetical protein	0.0052	0.036	1
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0014	0.0038	0.0043
Schistosoma mansoni	hypothetical protein	0.0077	0.0579	0.0933
Trichomonas vaginalis	transmembrane protein nessy, putative	0.0052	0.036	1
Echinococcus multilocularis	Membrane bound O acyl transferase, MBOAT	0.0052	0.036	0.0345
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0014	0.0038	0.0043
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0016	0.0056	0.004
Mycobacterium tuberculosis	Polyketide synthetase MbtC (polyketide synthase)	0.0013	0.0025	0.0356
Loa Loa (eye worm)	MH2 domain-containing protein	0.0077	0.0576	0.22
Schistosoma mansoni	tar DNA-binding protein	0.0088	0.0676	0.1092
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0014	0.0041	0.0719
Plasmodium falciparum	ataxin-2 like protein, putative	0.0036	0.0229	0.0838
Brugia malayi	AMP-binding enzyme family protein	0.0011	0.0014	0.0008
Mycobacterium ulcerans	fatty acid synthase Fas	0.0012	0.0016	0.0056
Brugia malayi	Isocitrate dehydrogenase	0.0012	0.0016	0.0015
Schistosoma mansoni	hypothetical protein	0.0077	0.0576	0.0926
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0014	0.0041	0.0719
Brugia malayi	diacylglycerol acyltransferase	0.0307	0.2561	1
Leishmania major	glycerol uptake protein, putative	0.0052	0.036	1
Echinococcus multilocularis	protein cysteine N palmitoyltransferase	0.0052	0.036	0.0345
Schistosoma mansoni	hypothetical protein	0.0717	0.6098	1
Trichomonas vaginalis	DNA polymerase eta, putative	0.0014	0.0038	0.075
Mycobacterium tuberculosis	Probable polyketide synthase Pks7	0.0039	0.0255	0.6376
Leishmania major	DNA polymerase eta, putative	0.0014	0.0038	0.075
Leishmania major	glycerol uptake protein, putative	0.0052	0.036	1
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0579	0.2215
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC	0.0039	0.0255	0.6337
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0014	0.0041	0.0097
Trypanosoma cruzi	PAB1-binding protein , putative	0.0036	0.0229	0.6189
Echinococcus granulosus	GPCR family 2	0.0077	0.0579	0.0927
Schistosoma mansoni	hypothetical protein	0.0052	0.036	0.0572
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0038	0.1054
Toxoplasma gondii	acyl-CoA:diacylglycerol acyltransferase 1-related enzyme	0.0307	0.2561	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0014	0.0038	0.0644
Mycobacterium ulcerans	polyketide synthase	0.0037	0.0235	0.5834
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0031	0.0185	0.0284
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0052	0.036	0.0572
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0031	0.0185	0.0169
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0031	0.0185	0.0169
Schistosoma mansoni	hypothetical protein	0.0077	0.0579	0.0933
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0039	0.0255	0.6357
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0038	0.1054
Trypanosoma brucei	importin beta-1 subunit, putative	0.002	0.0085	0.237
Loa Loa (eye worm)	acyl carrier protein	0.0017	0.0063	0.0184
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.003	0.0173	0.4188
Echinococcus granulosus	sterol O acyltransferase 1	0.0052	0.036	0.0566
Plasmodium falciparum	importin beta, putative	0.002	0.0085	0.0273
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0012	0.0016	0.0006
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0038	0.1054
Trypanosoma brucei	DNA polymerase IV, putative	0.0014	0.0038	0.1054
Loa Loa (eye worm)	MBOAT family protein	0.0052	0.036	0.1353
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0016	0.0053	0.1189
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0243	0.2014	0.7853
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0031	0.0185	0.0679
Mycobacterium ulcerans	polyketide synthase Pks9	0.0024	0.0127	0.2981
Loa Loa (eye worm)	hypothetical protein	0.0137	0.1098	0.425
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0014	0.0038	0.075
Echinococcus multilocularis	diacylglycerol O acyltransferase 1	0.0307	0.2561	0.2549
Giardia lamblia	DINP protein human, muc B family	0.0014	0.0038	0.9097
Plasmodium falciparum	ataxin-2 like protein, putative	0.0036	0.0229	0.0838
Toxoplasma gondii	type I fatty acid synthase, putative	0.0039	0.0255	0.0939
Loa Loa (eye worm)	membrane bound O-acyltransferase domain containing 1	0.0052	0.036	0.1353
Loa Loa (eye worm)	hhat protein	0.0052	0.036	0.1353
Echinococcus granulosus	importin subunit beta 1	0.002	0.0085	0.0114
Plasmodium vivax	diacylglycerol O-acyltransferase, putative	0.0307	0.2561	1
Schistosoma mansoni	hypothetical protein	0.021	0.1728	0.282
Trichomonas vaginalis	importin beta-1, putative	0.0016	0.0053	0.1189
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0014	0.0038	0.0644
Leishmania major	hypothetical protein, conserved	0.0036	0.0229	0.6232
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0052	0.036	0.0345
Brugia malayi	RNA, U transporter 1	0.0056	0.0398	0.1516
Trypanosoma brucei	glycerol uptake protein, putative	0.0052	0.036	1
Mycobacterium tuberculosis	Probable polyketide synthase Pks5	0.0036	0.0225	0.5599
Loa Loa (eye worm)	hypothetical protein	0.0255	0.2117	0.8253
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0052	0.036	0.0345
Leishmania major	glycerol uptake protein, putative	0.0052	0.036	1
Entamoeba histolytica	hypothetical protein	0.0077	0.0576	1
Loa Loa (eye worm)	fatty acid synthase	0.0037	0.0231	0.0845
Loa Loa (eye worm)	TAR-binding protein	0.0088	0.0676	0.2595
Brugia malayi	hypothetical protein	0.0077	0.0576	0.2212

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 28 nM	Inhibition of human recombinant His6-tagged DGAT1 expressed in insect Sf9 cells	ChEMBL.	24900485
IC50 (binding)	> 10000 nM	Inhibition of DGAT1 in mouse C2C12 cells assessed as reduction in triglyceride synthesis after 2 hrs by LC/MS analysis	ChEMBL.	24900485
permeability (ADMET)	= 1.3 ucm/s	Permeability from apical to basal side of human Caco2 cells	ChEMBL.	24900485

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2063281

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1671058