Detailed information for compound 1675695

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 356.42 | Formula: C22H20N4O
  • H donors: 1 H acceptors: 3 LogP: 3.49 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1c(cccc1C)CNC(=O)c1cnn2c1nccc2c1ccccc1
  • InChi: 1S/C22H20N4O/c1-15-7-6-10-18(16(15)2)13-24-22(27)19-14-25-26-20(11-12-23-21(19)26)17-8-4-3-5-9-17/h3-12,14H,13H2,1-2H3,(H,24,27)
  • InChiKey: KSOOVKODAWUURJ-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens aurora kinase B Starlite/ChEMBL No references
Homo sapiens mitogen-activated protein kinase-activated protein kinase 2 Starlite/ChEMBL No references
Homo sapiens Pim-1 proto-oncogene, serine/threonine kinase Starlite/ChEMBL No references
Homo sapiens glycogen synthase kinase 3 alpha Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens cyclin-dependent kinase 3 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi Serine/threonine-protein kinase Pim-3 Get druggable targets OG5_134863 All targets in OG5_134863
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase Get druggable targets OG5_131483 All targets in OG5_131483
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium hominis protein kinase (EC 2.7.1.-) p46XlEg22 Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CAMK/PIM protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Schistosoma mansoni protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) CAMK/PIM protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis MAP kinase activated protein kinase 2 Get druggable targets OG5_131483 All targets in OG5_131483
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K04702 proto-oncogene serine/threonine-protein kinase Pim-1, putative Get druggable targets OG5_134863 All targets in OG5_134863
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum hypothetical protein Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania donovani Aurora I-related kinase Get druggable targets OG5_127024 All targets in OG5_127024
Onchocerca volvulus Serine\/threonine protein kinase homolog Get druggable targets OG5_134863 All targets in OG5_134863
Brugia malayi serine/threonine protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus proto oncogene serine:threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K08850 aurora kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi aurora B kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus MAP kinase activated protein kinase 2 Get druggable targets OG5_131483 All targets in OG5_131483
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium vivax serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi map kinase activated protein kinase protein 2 Get druggable targets OG5_131483 All targets in OG5_131483
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium berghei serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_131483 All targets in OG5_131483
Leishmania mexicana protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_134863 All targets in OG5_134863
Giardia lamblia Aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica serine/threonine- protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase , putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica serine/threonine- protein kinase 6 , putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K04443 mitogen-activated protein kinase-activated protein kinase 2, putative Get druggable targets OG5_131483 All targets in OG5_131483
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi serine/threonine kinase 12 Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis proto oncogene serine:threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium yoelii putative protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania infantum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi serine/threonine-protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Serine/threonine-protein kinase 12, putative Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium falciparum serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 aurora kinase B 303 aa 299 aa 22.1 %
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase-activated protein kinase 2 370 aa 303 aa 26.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi larval opioid receptor 0.0033 0.0308 0.091
Mycobacterium ulcerans esterase/lipase LipP 0.003 0.0261 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0033 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Brugia malayi G-protein coupled receptor 0.0033 0.0308 0.091
Loa Loa (eye worm) hypothetical protein 0.002 0.0095 0.0281
Mycobacterium tuberculosis Probable esterase LipL 0.003 0.0261 0.0892
Echinococcus multilocularis fmrfamide receptor 0.0033 0.0308 0.0308
Onchocerca volvulus 0.0033 0.0308 0.072
Echinococcus granulosus biogenic amine 5HT receptor 0.0033 0.0308 0.0308
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0667 0.3947
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0308 0.0308
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.011 0.0649
Schistosoma mansoni adenoreceptor 0.0033 0.0308 0.0308
Echinococcus granulosus neuropeptides capa receptor 0.0033 0.0308 0.0308
Schistosoma mansoni opsin-like receptor 0.0033 0.0308 0.0308
Trichomonas vaginalis chromobox protein, putative 0.0032 0.0288 0.1703
Giardia lamblia Kinase, CMGC CDK 0.0055 0.0667 0.3947
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0033 0.0308 0.0308
Brugia malayi AKH receptor 0.0033 0.0308 0.091
Echinococcus granulosus tachykinin peptides receptor 99D 0.0033 0.0308 0.0308
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0251 0.1485
Echinococcus granulosus MAP kinase activated protein kinase 2 0.022 0.3389 0.3389
Schistosoma mansoni growth hormone secretagogue receptor 0.0033 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Echinococcus multilocularis neuropeptide receptor A26 0.0033 0.0308 0.0308
Schistosoma mansoni kinase 0.0061 0.0767 0.0767
Echinococcus multilocularis neuropeptide Y receptor 0.0033 0.0308 0.0308
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0308 0.0308
Onchocerca volvulus 0.0033 0.0308 0.072
Schistosoma mansoni protein kinase 0.0071 0.0931 0.0931
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0308 0.0308
Mycobacterium ulcerans lipase LipD 0.003 0.0261 1
Echinococcus multilocularis neuropeptide receptor 0.0622 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0308 0.0308
Brugia malayi intermediate filament protein 0.002 0.0101 0.0299
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0033 0.0308 0.0308
Schistosoma mansoni amine GPCR 0.0033 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.0052 0.0615 0.1815
Loa Loa (eye worm) hypothetical protein 0.003 0.0261 0.0769
Entamoeba histolytica protein kinase domain containing protein 0.0071 0.0931 0.5508
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0034 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Onchocerca volvulus 0.0033 0.0308 0.072
Schistosoma mansoni serine/threonine protein kinase 0.0071 0.0931 0.0931
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0033 0.0308 0.091
Mycobacterium tuberculosis Probable lipase LipE 0.003 0.0261 0.0892
Brugia malayi beta-lactamase family protein 0.003 0.0261 0.0769
Brugia malayi putative neuropeptide receptor NPR1 0.0033 0.0308 0.091
Schistosoma mansoni biogenic amine receptor 0.0033 0.0308 0.0308
Echinococcus granulosus tm gpcr rhodopsin 0.0033 0.0308 0.0308
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0308 0.0308
Brugia malayi Intermediate filament tail domain containing protein 0.002 0.0101 0.0299
Toxoplasma gondii aurora kinase 0.0071 0.0931 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0033 0.0308 0.0308
Schistosoma mansoni hypothetical protein 0.0033 0.0308 0.0308
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0195 0.2977 1
Trichomonas vaginalis chromobox protein, putative 0.0052 0.0631 0.3731
Mycobacterium tuberculosis Conserved protein 0.003 0.0261 0.0892
Brugia malayi Serotonin receptor 0.0033 0.0308 0.091
Echinococcus multilocularis cyclin dependent kinase 0.0055 0.0667 0.0667
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0195 0.2977 0.2977
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Schistosoma mansoni chromobox protein 0.0052 0.0631 0.0631
Brugia malayi follicle stimulating hormone receptor 0.0033 0.0308 0.091
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.002 0.0101 0.0299
Brugia malayi intracellular kinase 0.0061 0.0765 0.2256
Trichomonas vaginalis AGC family protein kinase 0.0071 0.0931 0.5508
Echinococcus multilocularis chromobox protein 1 0.0052 0.0631 0.0631
Brugia malayi RE15519p 0.0033 0.0308 0.091
Brugia malayi hypothetical protein 0.0033 0.0308 0.091
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Schistosoma mansoni serine/threonine protein kinase 0.0117 0.169 0.169
Echinococcus granulosus neuropeptide receptor A26 0.0033 0.0308 0.0308
Trichomonas vaginalis AGC family protein kinase 0.0071 0.0931 0.5508
Echinococcus multilocularis geminin 0.0128 0.1868 0.1868
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0032 0.0288 0.0649
Brugia malayi neuropeptide F receptor 0.0033 0.0308 0.091
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0033 0.0308 0.091
Echinococcus multilocularis serotonin receptor 0.0033 0.0308 0.0308
Trichomonas vaginalis penicillin-binding protein, putative 0.003 0.0261 0.1541
Echinococcus granulosus intermediate filament protein 0.002 0.0101 0.0101
Onchocerca volvulus 0.0033 0.0308 0.072
Brugia malayi Dopamine receptor protein 2 0.0033 0.0308 0.091
Giardia lamblia Kinase, CMGC CDK 0.0055 0.0667 0.3947
Trypanosoma brucei protein kinase, putative 0.0061 0.0765 0.4524
Echinococcus granulosus neuropeptide Y receptor 0.0033 0.0308 0.0308
Schistosoma mansoni intermediate filament proteins 0.002 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0023 0.0146 0.0432
Schistosoma mansoni hypothetical protein 0.0033 0.0308 0.0308
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0195 0.2977 0.2977
Onchocerca volvulus 0.0033 0.0308 0.072
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0033 0.0308 0.0308
Echinococcus multilocularis cyclin dependent kinase 1 0.0055 0.0667 0.0667
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.003 0.0261 0.0769
Trypanosoma cruzi cdc2-related kinase 3 0.0055 0.0667 0.3947
Brugia malayi hypothetical protein 0.0033 0.0308 0.091
Loa Loa (eye worm) hypothetical protein 0.0029 0.0251 0.0741
Brugia malayi G protein-coupled receptor F59B2.13 0.0033 0.0308 0.091
Loa Loa (eye worm) beta-lactamase 0.003 0.0261 0.0769
Echinococcus granulosus g protein coupled receptor 0.0033 0.0308 0.0308
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0308 0.0308
Echinococcus multilocularis neuropeptide Y receptor 0.0033 0.0308 0.0308
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0033 0.0308 0.0308
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0195 0.2977 0.8786
Brugia malayi hypothetical protein 0.0033 0.0308 0.091
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0033 0.0308 0.0308
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0261 0.1541
Brugia malayi G protein-coupled receptor 0.0033 0.0308 0.091
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Echinococcus multilocularis beta LACTamase domain containing family member 0.003 0.0261 0.0261
Echinococcus multilocularis protein kinase shaggy 0.0061 0.0765 0.0765
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0033 0.0308 0.0308
Echinococcus granulosus geminin 0.0128 0.1868 0.1868
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0033 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Echinococcus granulosus orexin receptor type 2 0.0033 0.0308 0.0308
Schistosoma mansoni opsin-like receptor 0.0033 0.0308 0.0308
Trichomonas vaginalis CAMK family protein kinase 0.0117 0.169 1
Brugia malayi beta-lactamase 0.003 0.0261 0.0769
Brugia malayi hypothetical protein 0.0033 0.0308 0.091
Echinococcus multilocularis neuropeptides capa receptor 0.0033 0.0308 0.0308
Schistosoma mansoni neuropeptide F-like receptor 0.0033 0.0308 0.0308
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0033 0.0308 0.091
Trichomonas vaginalis CAMK family protein kinase 0.0117 0.169 1
Schistosoma mansoni serine/threonine protein kinase 0.0195 0.2977 0.2977
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0061 0.0765 0.0765
Trichomonas vaginalis AGC family protein kinase 0.0071 0.0931 0.5508
Echinococcus granulosus cyclin dependent kinase 5 0.0055 0.0667 0.0667
Brugia malayi Protein kinase domain containing protein 0.0055 0.0667 0.1969
Trichomonas vaginalis D-aminoacylase, putative 0.003 0.0261 0.1541
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0055 0.0667 0.0667
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0033 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Mycobacterium leprae Probable lipase LipE 0.003 0.0261 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0308 0.0308
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0033 0.0308 0.091
Onchocerca volvulus 0.0033 0.0308 0.072
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0251 0.1485
Brugia malayi Dopamine receptor 0.0033 0.0308 0.091
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0308 0.0308
Echinococcus granulosus hypothetical protein 0.0033 0.0308 0.0308
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0667 0.0667
Echinococcus granulosus neuropeptides capa receptor 0.0033 0.0308 0.0308
Entamoeba histolytica protein kinase, putative 0.0061 0.0765 0.4524
Trichomonas vaginalis CAMK family protein kinase 0.0117 0.169 1
Entamoeba histolytica cell division protein kinase 2, putative 0.0055 0.0667 0.3947
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Echinococcus granulosus sex peptide receptor 0.0033 0.0308 0.0308
Echinococcus granulosus aurora kinase A 0.0071 0.0931 0.0931
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0308 0.0308
Trypanosoma brucei cdc2-related kinase 3 0.0055 0.0667 0.3947
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0667 0.3947
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0033 0.0308 0.0308
Schistosoma mansoni chromobox protein 0.0052 0.0631 0.0631
Onchocerca volvulus 0.0033 0.0308 0.072
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0308 0.0308
Trypanosoma cruzi polo-like protein kinase, putative 0.0117 0.169 1
Echinococcus multilocularis neuropeptide s receptor 0.0033 0.0308 0.0308
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0765 0.4524
Mycobacterium tuberculosis Conserved protein 0.003 0.0261 0.0892
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0071 0.0931 0.5508
Entamoeba histolytica protein kinase, putative 0.0071 0.0931 0.5508
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0033 0.0308 0.072
Echinococcus granulosus tm gpcr rhodopsin 0.0033 0.0308 0.0308
Brugia malayi hypothetical protein 0.0033 0.0308 0.091
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0033 0.0308 0.0308
Loa Loa (eye worm) AUR protein kinase 0.0071 0.0931 0.2747
Loa Loa (eye worm) G-protein coupled receptor 0.0033 0.0308 0.091
Loa Loa (eye worm) intermediate filament protein 0.002 0.0101 0.0299
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Schistosoma mansoni neuropeptide F-like receptor 0.0033 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Plasmodium vivax protein kinase Crk2 0.0055 0.0667 0.7167
Echinococcus multilocularis sex peptide receptor 0.0033 0.0308 0.0308
Echinococcus granulosus fmrfamide receptor 0.0033 0.0308 0.0308
Trichomonas vaginalis CAMK family protein kinase 0.0059 0.0742 0.439
Echinococcus granulosus g protein coupled receptor 0.0033 0.0308 0.0308
Schistosoma mansoni amine GPCR 0.0033 0.0308 0.0308
Schistosoma mansoni opsin-like receptor 0.0033 0.0308 0.0308
Onchocerca volvulus 0.0033 0.0308 0.072
Loa Loa (eye worm) AUR protein kinase 0.0071 0.0931 0.2747
Onchocerca volvulus 0.0033 0.0308 0.072
Brugia malayi ORL1-like opioid receptor 0.0033 0.0308 0.091
Entamoeba histolytica protein kinase domain containing protein 0.0061 0.0765 0.4524
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0308 0.0308
Echinococcus multilocularis musashi 0.002 0.0101 0.0101
Schistosoma mansoni serine/threonine protein kinase 0.022 0.3389 0.3389
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Plasmodium falciparum glycogen synthase kinase 3 0.0061 0.0765 0.8215
Echinococcus multilocularis somatostatin receptor 0.0033 0.0308 0.0308
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0033 0.0308 0.0308
Trypanosoma brucei cdc2-related kinase 1 0.0055 0.0667 0.3947
Echinococcus multilocularis serotonin receptor 0.0033 0.0308 0.0308
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0071 0.0931 0.0931
Echinococcus granulosus cyclin dependent kinase 0.0055 0.0667 0.0667
Entamoeba histolytica cell division protein kinase 2, putative 0.0055 0.0667 0.3947
Schistosoma mansoni lamin 0.002 0.0101 0.0101
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0033 0.0308 0.0308
Schistosoma mansoni amine GPCR 0.0033 0.0308 0.0308
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0308 0.0308
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0033 0.0308 0.0308
Trichomonas vaginalis AGC family protein kinase 0.0071 0.0931 0.5508
Echinococcus granulosus g protein coupled receptor 0.0033 0.0308 0.0308
Onchocerca volvulus Serine\/threonine kinase homolog 0.0117 0.169 0.5524
Onchocerca volvulus 0.003 0.0261 0.0554
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0308 0.0308
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0308 0.0308
Echinococcus granulosus G protein coupled receptor 139 0.0033 0.0308 0.0308
Trichomonas vaginalis D-aminoacylase, putative 0.003 0.0261 0.1541
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0308 0.0308
Echinococcus granulosus chromobox protein 1 0.0052 0.0631 0.0631
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0033 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.003 0.0261 0.0769
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0061 0.0765 0.2256
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0033 0.0308 0.0308
Brugia malayi hypothetical protein 0.0033 0.0308 0.091
Onchocerca volvulus 0.003 0.0261 0.0554
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0308 0.0308
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0055 0.0667 0.1969
Loa Loa (eye worm) melatonin receptor type 1A 0.0033 0.0308 0.091
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0033 0.0308 0.091
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0261 0.1541
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Leishmania major hypothetical protein, conserved 0.003 0.0261 0.1541
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0192 0.2921 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0033 0.0308 0.0308
Echinococcus multilocularis fmrfamide receptor 0.0033 0.0308 0.0308
Onchocerca volvulus 0.0033 0.0308 0.072
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0034 0.0334 0.0334
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.022 0.3389 0.3389
Onchocerca volvulus 0.003 0.0261 0.0554
Trichomonas vaginalis chromobox protein, putative 0.0052 0.0631 0.3731
Entamoeba histolytica protein kinase, putative 0.0071 0.0931 0.5508
Brugia malayi Heterochromatin protein 1 0.0052 0.0631 0.1861
Echinococcus granulosus allatostatin A receptor 0.0033 0.0308 0.0308
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0308 0.0308
Schistosoma mansoni hypothetical protein 0.0128 0.1868 0.1868
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0308 0.0308
Entamoeba histolytica protein kinase domain containing protein 0.0061 0.0765 0.4524
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Brugia malayi hypothetical protein 0.0033 0.0308 0.091
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0071 0.0931 1
Trichomonas vaginalis CAMK family protein kinase 0.0117 0.169 1
Echinococcus granulosus cyclin dependent kinase 1 0.0055 0.0667 0.0667
Toxoplasma gondii ABC1 family protein 0.003 0.0261 0.2799
Trichomonas vaginalis chromobox protein, putative 0.0032 0.0288 0.1703
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0061 0.0765 0.0765
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0033 0.0308 0.091
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0667 0.3947
Brugia malayi Dopamine receptor protein 1 0.0033 0.0308 0.091
Brugia malayi G-protein coupled receptor 0.0033 0.0308 0.091
Loa Loa (eye worm) heterochromatin protein 1 0.0052 0.0631 0.1861
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0117 0.169 0.169
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0061 0.0765 0.4524
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0055 0.0667 0.7167
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0033 0.0308 0.0308
Trypanosoma cruzi cdc2-related kinase 1 0.0055 0.0667 0.3947
Mycobacterium ulcerans beta-lactamase 0.003 0.0261 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Schistosoma mansoni hypothetical protein 0.0033 0.0308 0.0308
Mycobacterium tuberculosis Probable hydrolase 0.003 0.0261 0.0892
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0061 0.0765 0.8215
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0033 0.0308 0.091
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0033 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0117 0.169 0.169
Schistosoma mansoni neuropeptide receptor 0.0033 0.0308 0.0308
Brugia malayi serine/threonine-protein kinase 6 0.0071 0.0931 0.2747
Brugia malayi sulfakinin receptor protein 0.0033 0.0308 0.091
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.003 0.0261 0.0261
Brugia malayi serine/threonine kinase 12 0.0071 0.0931 0.2747
Onchocerca volvulus 0.0033 0.0308 0.072
Echinococcus granulosus protein kinase shaggy 0.0061 0.0765 0.0765
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0071 0.0931 0.5508
Brugia malayi hypothetical protein 0.0033 0.0308 0.091
Brugia malayi hypothetical protein 0.0033 0.0308 0.091
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0033 0.0308 0.0308
Treponema pallidum exodeoxyribonuclease (exoA) 0.0014 0 0.5
Giardia lamblia Kinase, CMGC GSK 0.0061 0.0765 0.4524
Schistosoma mansoni histamine h1 receptor 0.0033 0.0308 0.0308
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.003 0.0261 0.0892
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0308 0.0308
Trichomonas vaginalis CAMK family protein kinase 0.0059 0.0742 0.439
Brugia malayi Serotonin receptor 0.0033 0.0308 0.091
Echinococcus granulosus 7tm_1 domain containing protein 0.0033 0.0308 0.0308
Echinococcus granulosus neuropeptide s receptor 0.0033 0.0308 0.0308
Echinococcus multilocularis neuropeptides capa receptor 0.0033 0.0308 0.0308
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.003 0.0261 1
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0055 0.0667 0.3947
Brugia malayi Melatonin receptor type 1A 0.0033 0.0308 0.091
Plasmodium vivax hypothetical protein, conserved 0.003 0.0261 0.2799
Brugia malayi chromobox protein homolog 3 0.0029 0.0251 0.0741
Echinococcus multilocularis lamin dm0 0.002 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.002 0.0101 0.0299
Schistosoma mansoni hypothetical protein 0.0033 0.0308 0.0308
Echinococcus multilocularis dro:myosuppressin receptor 0.0033 0.0308 0.0308
Schistosoma mansoni amine GPCR 0.0033 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.011 0.0649
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Trichomonas vaginalis CAMK family protein kinase 0.0117 0.169 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0034 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Brugia malayi GnHR receptor homolog 0.0033 0.0308 0.091
Schistosoma mansoni neuropeptide receptor 0.0033 0.0308 0.0308
Echinococcus granulosus lamin 0.002 0.0101 0.0101
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0033 0.0308 0.0308
Echinococcus granulosus neuropeptide FF receptor 2 0.0033 0.0308 0.0308
Onchocerca volvulus 0.0033 0.0308 0.072
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0117 0.169 0.4987
Brugia malayi serine/threonine-protein kinase plk-2 0.0117 0.169 0.4987
Loa Loa (eye worm) neuropeptide F receptor 0.0033 0.0308 0.091
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0195 0.2977 0.8786
Echinococcus granulosus alpha 1A adrenergic receptor 0.0033 0.0308 0.0308
Loa Loa (eye worm) AUR protein kinase 0.0071 0.0931 0.2747
Echinococcus granulosus g-protein coupled receptor 0.0033 0.0308 0.0308
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0033 0.0308 0.0308
Loa Loa (eye worm) neuropeptide F receptor 0.0033 0.0308 0.091
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0055 0.0667 0.1969
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Brugia malayi putative neuropeptide receptor 0.0033 0.0308 0.091
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0667 0.0667
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Onchocerca volvulus 0.0033 0.0308 0.072
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0014 0 0.5
Loa Loa (eye worm) hypothetical protein 0.003 0.0261 0.0769
Loa Loa (eye worm) TYRA-2 protein 0.0033 0.0308 0.091
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0195 0.2977 0.8786
Echinococcus granulosus somatostatin receptor 0.0033 0.0308 0.0308
Brugia malayi Tachykinin-like peptides receptor 99D 0.0033 0.0308 0.091
Loa Loa (eye worm) hypothetical protein 0.003 0.0261 0.0769
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0033 0.0308 0.0308
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0033 0.0308 0.0308
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0055 0.0667 0.1969
Onchocerca volvulus 0.0033 0.0308 0.072
Onchocerca volvulus Neuropeptide F receptor homolog 0.0033 0.0308 0.072
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0765 0.4524
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0033 0.0308 0.0308
Echinococcus multilocularis aurora kinase A 0.0071 0.0931 0.0931
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0033 0.0308 0.091
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0029 0.0251 0.0521
Echinococcus multilocularis orexin receptor type 2 0.0033 0.0308 0.0308
Onchocerca volvulus 0.0061 0.0765 0.2307
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0117 0.169 1
Trypanosoma brucei polo-like protein kinase 0.0117 0.169 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0308 0.0308
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0033 0.0308 0.0308
Echinococcus granulosus tm gpcr rhodopsin 0.0033 0.0308 0.0308
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0061 0.0765 0.2256
Echinococcus granulosus 7TM GPCR rhodopsin 0.0033 0.0308 0.0308
Echinococcus multilocularis neuropeptide receptor 0.0033 0.0308 0.0308
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.003 0.0261 0.0769
Echinococcus granulosus neuropeptide receptor 0.0033 0.0308 0.0308
Echinococcus granulosus beta LACTamase domain containing family member 0.003 0.0261 0.0261
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0034 0.0334 0.0985
Echinococcus multilocularis cyclin dependent kinase 1 0.0055 0.0667 0.0667
Echinococcus multilocularis allatostatin A receptor 0.0033 0.0308 0.0308
Echinococcus multilocularis g protein coupled receptor 0.0033 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0061 0.0765 0.0765
Trichomonas vaginalis CAMK family protein kinase 0.0117 0.169 1
Onchocerca volvulus 0.0033 0.0308 0.072
Giardia lamblia Kinase, CMGC GSK 0.0061 0.0765 0.4524
Onchocerca volvulus 0.0033 0.0308 0.072
Echinococcus granulosus dro:myosuppressin receptor 0.0033 0.0308 0.0308
Brugia malayi hypothetical protein 0.0033 0.0308 0.091
Schistosoma mansoni hypothetical protein 0.0128 0.1868 0.1868
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0034 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Mycobacterium leprae conserved hypothetical protein 0.003 0.0261 0.5
Schistosoma mansoni neuropeptide receptor 0.0033 0.0308 0.0308
Schistosoma mansoni alpha-1 adrenergic receptor 0.0033 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0308 0.0308
Echinococcus multilocularis cyclin dependent kinase 5 0.0055 0.0667 0.0667
Mycobacterium ulcerans hypothetical protein 0.003 0.0261 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0033 0.0308 0.0308
Echinococcus granulosus serotonin receptor 0.0033 0.0308 0.0308
Mycobacterium tuberculosis Conserved protein 0.003 0.0261 0.0892
Brugia malayi Protein kinase domain containing protein 0.0195 0.2977 0.8786
Echinococcus granulosus chromobox protein 1 0.0052 0.0631 0.0631
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Trypanosoma cruzi polo-like protein kinase, putative 0.0117 0.169 1
Giardia lamblia Aurora kinase 0.0071 0.0931 0.5508
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0033 0.0308 0.0308
Schistosoma mansoni biogenic amine (5HT) receptor 0.0033 0.0308 0.0308
Brugia malayi beta-lactamase family protein 0.003 0.0261 0.0769
Mycobacterium tuberculosis Probable lipase LipD 0.003 0.0261 0.0892
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Echinococcus multilocularis g protein coupled receptor 0.0033 0.0308 0.0308
Schistosoma mansoni neuropeptide receptor 0.0622 1 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0033 0.0308 0.0308
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0055 0.0667 0.3947
Schistosoma mansoni biogenic amine (5HT) receptor 0.0033 0.0308 0.0308
Echinococcus granulosus neuropeptide Y receptor 0.0033 0.0308 0.0308
Trypanosoma brucei hypothetical protein, conserved 0.003 0.0261 0.1541
Trypanosoma brucei aurora B kinase 0.0071 0.0931 0.5508
Schistosoma mansoni neuropeptide f receptor 76f 0.0033 0.0308 0.0308
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0034 0.0334 0.0985
Echinococcus multilocularis g protein coupled receptor 0.0033 0.0308 0.0308
Trypanosoma cruzi cdc2-related kinase 3 0.0055 0.0667 0.3947
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Entamoeba histolytica protein kinase , putative 0.0071 0.0931 0.5508
Trypanosoma cruzi aurora B kinase, putative 0.0071 0.0931 0.5508
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Trichomonas vaginalis CAMK family protein kinase 0.0117 0.169 1
Echinococcus granulosus lamin dm0 0.002 0.0101 0.0101
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0071 0.0931 0.5508
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0308 0.0308
Schistosoma mansoni amine GPCR 0.0033 0.0308 0.0308
Echinococcus multilocularis G-protein coupled receptor, putative 0.0033 0.0308 0.0308
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0033 0.0308 0.091
Loa Loa (eye worm) G-protein coupled receptor 0.0033 0.0308 0.091
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0033 0.0308 0.0308
Giardia lamblia Kinase, PLK 0.0117 0.169 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.003 0.0261 0.0261
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0033 0.0308 0.0308
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0034 0.0334 0.0334
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0033 0.0308 0.0308
Schistosoma mansoni lamin 0.002 0.0101 0.0101
Trichomonas vaginalis esterase, putative 0.003 0.0261 0.1541
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0033 0.0308 0.091
Trichomonas vaginalis penicillin-binding protein, putative 0.003 0.0261 0.1541
Echinococcus multilocularis G protein coupled receptor 139 0.0622 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0033 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.003 0.0261 0.0892
Brugia malayi map kinase activated protein kinase protein 2 0.022 0.3389 1
Schistosoma mansoni biogenic amine receptor 0.0033 0.0308 0.0308
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0071 0.0931 0.0931
Echinococcus multilocularis lamin 0.002 0.0101 0.0101
Brugia malayi cell division control protein 2 homolog 0.0055 0.0667 0.1969
Echinococcus multilocularis g-protein coupled receptor 0.0033 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.003 0.0261 0.0769
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Trypanosoma cruzi cdc2-related kinase 1 0.0055 0.0667 0.3947
Leishmania major protein kinase, putative 0.0071 0.0931 0.5508
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0034 0.0334 0.0334
Entamoeba histolytica serine/threonine protein kinase, putative 0.0117 0.169 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.003 0.0261 0.0892
Schistosoma mansoni myosin xvIII 0.0033 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.003 0.0261 0.0769
Onchocerca volvulus 0.0023 0.0146 0.0157
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0033 0.0308 0.0308
Echinococcus multilocularis chromobox protein 1 0.0052 0.0631 0.0631
Plasmodium falciparum serine/threonine protein kinase, putative 0.0071 0.0931 1
Schistosoma mansoni biogenic amine receptor 0.0033 0.0308 0.0308
Brugia malayi serine/threonine protein kinase 6 0.0071 0.0931 0.2747
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0061 0.0765 0.4524
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0308 0.0308
Echinococcus multilocularis neuropeptide FF receptor 2 0.0033 0.0308 0.0308
Trichomonas vaginalis D-aminoacylase, putative 0.003 0.0261 0.1541
Brugia malayi neuropeptide F receptor 0.0033 0.0308 0.091
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0034 0.0334 0.0334
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0308 0.0308
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.022 0.3389 1
Plasmodium falciparum protein kinase 5 0.0055 0.0667 0.7167
Onchocerca volvulus 0.0033 0.0308 0.072
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.091
Plasmodium vivax glycogen synthase kinase 3, putative 0.0061 0.0765 0.8215

Activities

Activity type Activity value Assay description Source Reference
Ki (functional) = 5.1 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: GSK3A ChEMBL. No reference
Ki (functional) = 5.1 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PLK1 ChEMBL. No reference
Ki (functional) = 5.3 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PIM1 ChEMBL. No reference
Ki (functional) = 5.6 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MAPKAPK2 ChEMBL. No reference
Ki (functional) = 5.6 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CDC2 ChEMBL. No reference
Ki (functional) = 5.8 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: STK12 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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