TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 484.522 | Formula: C24H24N2O7S
H donors: 2 H acceptors: 5 LogP: 2.74 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(OC)c(cc1NC(=O)CCC(=O)O)S(=O)(=O)N(c1ccccc1)c1ccccc1
InChi: 1S/C24H24N2O7S/c1-32-20-16-21(33-2)22(15-19(20)25-23(27)13-14-24(28)29)34(30,31)26(17-9-5-3-6-10-17)18-11-7-4-8-12-18/h3-12,15-16H,13-14H2,1-2H3,(H,25,27)(H,28,29)
InChiKey: STMGMKFOBAHRLB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Escherichia coli	fused N-acetyl glucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyl transferase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium tuberculosis	Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU	Get druggable targets OG5_131193	All targets in OG5_131193
Mycobacterium ulcerans	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase	Get druggable targets OG5_131193	All targets in OG5_131193
Wolbachia endosymbiont of Brugia malayi	N-acetylglucosamine-1-phosphate uridyltransferase	Get druggable targets OG5_131193	All targets in OG5_131193
Mycobacterium leprae	Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU	Get druggable targets OG5_131193	All targets in OG5_131193

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0871	0.3346
Echinococcus multilocularis	exonuclease 1	0.0005	0.0021	0.0079
Plasmodium falciparum	DNA repair protein RAD2, putative	0.0005	0.0021	0.0455
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0038	0.1009
Loa Loa (eye worm)	MH2 domain-containing protein	0.0009	0.0071	0.0389
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0006	0.0033
Plasmodium vivax	exonuclease I, putative	0.0005	0.0021	0.0455
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0038	0.1009
Brugia malayi	latrophilin 2 splice variant baaae	0.0039	0.051	0.2805
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0125	0.1787	0.1782
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0009	0.0071	0.0271
Mycobacterium ulcerans	molybdopterin-guanine dinucleotide biosynthesis protein A	0.0125	0.1787	0.1572
Echinococcus granulosus	inositol polyphosphate 5 phosphatase OCRL 1	0.0004	0.0006	0.0023
Trichomonas vaginalis	exonuclease%2C+putative	0.0005	0.0021	0.0455
Echinococcus multilocularis	inositol polyphosphate 5 phosphatase OCRL 1	0.0004	0.0006	0.0023
Plasmodium falciparum	flap endonuclease 1	0.0026	0.0325	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0021	0.0256	0.7828
Echinococcus multilocularis	deoxyribonuclease 1 2	0.0004	0.0006	0.0023
Schistosoma mansoni	hypothetical protein	0.0018	0.0205	0.0789
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0021	0.0256	0.0982
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0006	0.0033
Entamoeba histolytica	DNA-repair protein, putative	0.0005	0.0021	0.0455
Schistosoma mansoni	hypothetical protein	0.0004	0.0006	0.0023
Echinococcus multilocularis	neutral sphingomyelinase	0.0004	0.0006	0.0023
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.0256	0.7828
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0056	0.0772	0.4249
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0006	0.0033
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0004	0.0006	0.0033
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0006	0.0033
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0006	0.0033
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0125	0.1787	0.1782
Echinococcus multilocularis	synaptojanin 1	0.0004	0.0006	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0006	0.0033
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.0038	0.1009
Loa Loa (eye worm)	Smad1	0.0009	0.0071	0.0389
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0256	0.7828
Loa Loa (eye worm)	hypothetical protein	0.0039	0.051	0.2805
Trichomonas vaginalis	flap endonuclease-1, putative	0.0005	0.0021	0.0455
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0004	0.0006	0.0023
Trypanosoma cruzi	DNA repair protein RAD2, putative	0.0005	0.0021	0.0455
Plasmodium vivax	flap endonuclease 1, putative	0.0026	0.0325	1
Schistosoma mansoni	carbon catabolite repressor protein	0.0004	0.0006	0.0023
Entamoeba histolytica	exonuclease, putative	0.0005	0.0021	0.0455
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0038	0.1009
Echinococcus granulosus	GPCR family 2	0.0018	0.0205	0.0789
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0061	0.0835	0.3209
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0038	0.1009
Loa Loa (eye worm)	CCR4-NOT transcription complex subunit 6 family protein	0.0004	0.0006	0.0033
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0006	0.0033
Echinococcus granulosus	tar DNA binding protein	0.0063	0.0871	0.3346
Schistosoma mansoni	hypothetical protein	0.0181	0.2603	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.0205	0.0789
Entamoeba histolytica	exonuclease, putative	0.0005	0.0021	0.0455
Brugia malayi	MH1 domain containing protein	0.0005	0.0014	0.0075
Brugia malayi	MH1 domain containing protein	0.0009	0.0071	0.0389
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0021	0.0256	0.7828
Echinococcus granulosus	neutral sphingomyelinase	0.0004	0.0006	0.0023
Mycobacterium ulcerans	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase	0.0684	1	1
Echinococcus granulosus	flap endonuclease 1	0.0026	0.0325	0.1249
Echinococcus granulosus	exonuclease 1	0.0005	0.0021	0.0079
Trypanosoma cruzi	DNA repair protein RAD2, putative	0.0005	0.0021	0.0455
Onchocerca volvulus		0.0004	0.0006	0.0167
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0038	0.1009
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0038	0.1009
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0006	0.0033
Schistosoma mansoni	exonuclease	0.0005	0.0021	0.0079
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0026	0.0325	1
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0054	0.074	0.412
Trichomonas vaginalis	flap endonuclease-1, putative	0.0026	0.0325	1
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0026	0.0325	1
Mycobacterium ulcerans	hypothetical protein	0.0125	0.1787	0.1572
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.0205	0.113
Schistosoma mansoni	neutral sphingomyelinase	0.0004	0.0006	0.0023
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0047	0.0182
Loa Loa (eye worm)	flap endonuclease-1	0.0026	0.0325	0.1789
Schistosoma mansoni	nocturnin	0.0004	0.0006	0.0023
Entamoeba histolytica	Flap nuclease, putative	0.0026	0.0325	1
Loa Loa (eye worm)	MH1 domain-containing protein	0.0009	0.0071	0.0389
Schistosoma mansoni	hypothetical protein	0.0181	0.2603	1
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0006	0.0033
Echinococcus multilocularis	tar DNA binding protein	0.0063	0.0871	0.3346
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0256	0.7828
Schistosoma mansoni	xp-G/rad2 DNA repair endonuclease family member	0.0005	0.0021	0.0079
Loa Loa (eye worm)	MH2 domain-containing protein	0.0127	0.1817	1
Schistosoma mansoni	synaptojanin	0.0004	0.0006	0.0023
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0871	0.3346
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0063	0.0871	0.4793
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.0038	0.1009
Schistosoma mansoni	cript-related	0.0004	0.0006	0.0023
Toxoplasma gondii	eukaryotic initiation factor-2B, gamma subunit, putative	0.0125	0.1787	1
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0871	0.3346
Trichomonas vaginalis	flap endonuclease-1, putative	0.0005	0.0021	0.0455
Brugia malayi	exodeoxyribonuclease III family protein	0.0021	0.0256	0.1407
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0038	0.1009
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0004	0.0006	0.0023
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.0205	0.0789
Echinococcus granulosus	cpg binding protein	0.003	0.0388	0.1489
Onchocerca volvulus	Putative neutral sphingomyelinase	0.0004	0.0006	0.0167
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0364	0.2001
Echinococcus granulosus	smad	0.0009	0.0071	0.0271
Echinococcus granulosus	geminin	0.0181	0.2603	1
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0021	0.0113
Echinococcus multilocularis	Smad4	0.0009	0.0071	0.0271
Schistosoma mansoni	hypothetical protein	0.0039	0.051	0.1958
Schistosoma mansoni	smad	0.0009	0.0071	0.0271
Loa Loa (eye worm)	RNA binding protein	0.0063	0.0871	0.4793
Schistosoma mansoni	cpg binding protein	0.003	0.0388	0.1489
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0038	0.1009
Echinococcus granulosus	DNA repair protein complementing XP G cells	0.0005	0.0021	0.0079
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0026	0.0325	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0038	0.1009
Brugia malayi	RNA recognition motif domain containing protein	0.0063	0.0871	0.4793
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0056	0.0772	0.4249
Echinococcus multilocularis	cpg binding protein	0.003	0.0388	0.1489
Brugia malayi	Flap endonuclease-1	0.0026	0.0325	0.1789
Brugia malayi	MH1 domain containing protein	0.0005	0.0014	0.0075
Schistosoma mansoni	cpg binding protein	0.0029	0.0364	0.1397
Toxoplasma gondii	XPG N-terminal domain-containing protein	0.0005	0.0021	0.0081
Trypanosoma brucei	exonuclease, putative	0.0005	0.0021	0.0455
Brugia malayi	RNA binding protein	0.0063	0.0871	0.4793
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0021	0.0256	0.1402
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0071	0.0271
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0256	0.7828
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0205	0.113
Wolbachia endosymbiont of Brugia malayi	N-acetylglucosamine-1-phosphate uridyltransferase	0.0684	1	1
Mycobacterium tuberculosis	Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU	0.0684	1	1
Brugia malayi	CCR4	0.0004	0.0006	0.0033
Plasmodium falciparum	exonuclease I, putative	0.0005	0.0021	0.0455
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0004	0.0003	0.0013
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0004	0.0006	0.0033
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0047	0.0182
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0006	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0006	0.0033
Treponema pallidum	licC protein (licC)	0.0125	0.1787	1
Echinococcus granulosus	CCR4 NOT transcription complex subunit 6	0.0004	0.0006	0.0023
Toxoplasma gondii	XPG N-terminal domain-containing protein	0.0005	0.0021	0.0081
Schistosoma mansoni	cpg binding protein	0.003	0.0388	0.1489
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0364	0.2001
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0071	0.0271
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0021	0.0113
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.0256	0.7828
Loa Loa (eye worm)	nuclear factor I	0.0005	0.0014	0.0075
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0004	0.0006	0.0033
Echinococcus granulosus	mothers against decapentaplegic 5	0.0009	0.0071	0.0271
Echinococcus multilocularis	geminin	0.0181	0.2603	1
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0021	0.0256	0.0982
Leishmania major	hypothetical protein, conserved	0.0005	0.0021	0.0455
Echinococcus multilocularis	CCR4 NOT transcription complex subunit 6	0.0004	0.0006	0.0023
Echinococcus multilocularis	traf and tnf receptor associated protein	0.0004	0.0006	0.0023
Mycobacterium ulcerans	hypothetical protein	0.0125	0.1787	0.1572
Schistosoma mansoni	hypothetical protein	0.0018	0.0205	0.0789
Schistosoma mansoni	ocrl type II inositol 5-phosphatase	0.0004	0.0006	0.0023
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0047	0.0182
Echinococcus granulosus	synaptojanin 1	0.0004	0.0006	0.0023
Brugia malayi	MH2 domain containing protein	0.0127	0.1817	1
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0038	0.1009
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0038	0.1009
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.0205	0.0789
Loa Loa (eye worm)	XPG I-region family protein	0.0005	0.0021	0.0113
Toxoplasma gondii	exonuclease III APE	0.0021	0.0256	0.1402
Schistosoma mansoni	synaptojanin	0.0004	0.0006	0.0023
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0047	0.0182
Brugia malayi	MH1 domain containing protein	0.0009	0.0071	0.0389
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0772	0.4249
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0021	0.0256	0.7828
Echinococcus granulosus	Smad4	0.0009	0.0071	0.0271
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0871	0.3346
Trypanosoma cruzi	hypothetical protein, conserved	0.0005	0.0021	0.0455
Trichomonas vaginalis	flap endonuclease-1, putative	0.0005	0.0021	0.0455
Schistosoma mansoni	hypothetical protein	0.0018	0.0205	0.0789
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0073	0.0281
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0256	0.7828
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0009	0.0071	0.0271
Echinococcus multilocularis	DNA repair protein complementing XP G cells	0.0005	0.0021	0.0079
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0056	0.0772	0.4249
Onchocerca volvulus		0.0029	0.0364	1
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0014	0.0075
Brugia malayi	MH2 domain containing protein	0.0009	0.0071	0.0389
Schistosoma mansoni	ap endonuclease	0.0021	0.0256	0.0982
Brugia malayi	MH2 domain containing protein	0.0009	0.0071	0.0389
Giardia lamblia	hypothetical protein	0.0005	0.0021	0.0455
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.0205	0.113
Echinococcus multilocularis	GPCR, family 2	0.0018	0.0205	0.0789
Trichomonas vaginalis	flap endonuclease-1, putative	0.0005	0.0021	0.0455
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0006	0.0033
Loa Loa (eye worm)	TAR-binding protein	0.0063	0.0871	0.4793
Schistosoma mansoni	Smad4	0.0009	0.0071	0.0271
Echinococcus multilocularis	flap endonuclease 1	0.0026	0.0325	0.1249
Echinococcus multilocularis	flap endonuclease GEN 1	0.0005	0.0021	0.0079
Giardia lamblia	Flap structure-specific endonuclease	0.0026	0.0325	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0005	0.0021	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0006	0.0033
Schistosoma mansoni	hypothetical protein	0.0018	0.0205	0.0789
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0871	0.3346
Brugia malayi	XPG I-region family protein	0.0005	0.0021	0.0113
Loa Loa (eye worm)	transcription factor SMAD2	0.0127	0.1817	1
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0021	0.0256	0.025
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0047	0.0182
Toxoplasma gondii	XPG N-terminal domain-containing protein	0.0005	0.0021	0.0081
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0004	0.0006	0.0033
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0038	0.1009
Trypanosoma brucei	DNA repair protein RAD2, putative	0.0005	0.0021	0.0455
Giardia lamblia	Exonuclease 1	0.0005	0.0021	0.0455
Echinococcus multilocularis	smad	0.0009	0.0071	0.0271
Brugia malayi	Smad1	0.0009	0.0071	0.0389
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0004	0.0006	0.0033
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0026	0.0325	0.1791
Echinococcus granulosus	flap endonuclease GEN 1	0.0005	0.0021	0.0079
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.0205	0.113
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0071	0.0271
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0009	0.0071	0.0271
Schistosoma mansoni	flap endonuclease-1	0.0023	0.0288	0.1108
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0073	0.0402
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0038	0.1009
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0038	0.1009
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0021	0.0256	0.1407
Schistosoma mansoni	xp-G/rad2 DNA repair endonuclease family	0.0005	0.0021	0.0079
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0073	0.0281
Schistosoma mansoni	ap endonuclease	0.0021	0.0256	0.0982
Plasmodium vivax	DNA repair protein RAD2, putative	0.0005	0.0021	0.0455
Echinococcus granulosus	traf and tnf receptor associated protein	0.0004	0.0006	0.0023
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0038	0.1009
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0071	0.0393
Trichomonas vaginalis	helicase, putative	0.0006	0.0038	0.1009
Brugia malayi	TAR-binding protein	0.0063	0.0871	0.4793
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0009	0.0071	0.0271
Onchocerca volvulus		0.0004	0.0006	0.0167
Toxoplasma gondii	XPG N-terminal domain-containing protein	0.0005	0.0021	0.0081
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0021	0.0256	0.7828
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.0205	0.0789

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 7.398	Inhibition of Escherichia coli GlmU acetyltransferase activity assessed as coenzyme A production using acetyl CoA substrate	ChEMBL.	25544688
IC50 (binding)	= 0.04 uM	Inhibition of Escherichia coli GlmU acetyltransferase activity assessed as coenzyme A production using acetyl CoA substrate	ChEMBL.	25544688

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2207599

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1685441