Detailed information for compound 169130

Basic information

Technical information
  • TDR Targets ID: 169130
  • Name: N-(2,6-dichlorophenyl)-2-morpholin-4-ylacetam ide
  • MW: 289.158 | Formula: C12H14Cl2N2O2
  • H donors: 1 H acceptors: 1 LogP: 2.05 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1c(Cl)cccc1Cl)CN1CCOCC1
  • InChi: 1S/C12H14Cl2N2O2/c13-9-2-1-3-10(14)12(9)15-11(17)8-16-4-6-18-7-5-16/h1-3H,4-8H2,(H,15,17)
  • InChiKey: OLMVHNZKOMIZER-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2,6-dichlorophenyl)-2-morpholino-acetamide
  • N-(2,6-dichlorophenyl)-2-morpholinoacetamide
  • N-(2,6-dichlorophenyl)-2-morpholin-4-yl-ethanamide
  • T5388432

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) RNA polymerase Rpb1 0.0106 0.2313 0.4825
Schistosoma mansoni hypothetical protein 0.0433 1 1
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0041 0.0033
Toxoplasma gondii DNA-directed RNA polymerase II RPB1 0.0106 0.2313 0.4769
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0035 0.0634 0.1352
Schistosoma mansoni DNA-directed RNA polymerase II largest subunit 0.0106 0.2313 0.2313
Trypanosoma brucei DNA-directed RNA polymerase III largest subunit, putative 0.0041 0.0781 0.1708
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0044 0.0044
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0025 0.0025
Trypanosoma brucei DNA-directed RNA polymerase III subunit C1 0.0106 0.2313 0.5416
Echinococcus multilocularis cpg binding protein 0.0032 0.0578 0.0578
Echinococcus multilocularis Smad4 0.0009 0.0025 0.0025
Brugia malayi TAR-binding protein 0.0067 0.1399 0.2896
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.2793 0.5836
Treponema pallidum DNA-directed RNA polymerase subunit beta' 0.0106 0.2313 0.5
Trichomonas vaginalis rotamase, putative 0.0035 0.0634 0.1017
Trypanosoma brucei DNA-directed RNA polymerase III largest subunit, putative 0.0065 0.1355 0.3097
Schistosoma mansoni DNA-directed RNA polymerase III largest subunit 0.0043 0.083 0.083
Schistosoma mansoni smad 0.0009 0.0025 0.0025
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0035 0.0654 0.1326
Loa Loa (eye worm) cytochrome P450 0.0019 0.0263 0.0502
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0025 0.0025
Entamoeba histolytica DNA-directed RNA polymerase III largest subunit, putative 0.0106 0.2313 0.4062
Schistosoma mansoni smad1 5 8 and 0.0009 0.0025 0.0025
Schistosoma mansoni smad1 5 8 and 0.0009 0.0025 0.0025
Brugia malayi MH2 domain containing protein 0.0126 0.2793 0.5836
Loa Loa (eye worm) hypothetical protein 0.0211 0.4768 1
Giardia lamblia RNA polymerase AI large subunit 0.0211 0.4768 1
Schistosoma mansoni Smad4 0.0009 0.0025 0.0025
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1399 0.1399
Echinococcus multilocularis 0.0019 0.0263 0.0263
Loa Loa (eye worm) hypothetical protein 0.0009 0.004 0.0033
Trypanosoma brucei RNA polymerase IIA largest subunit 0.0106 0.2313 0.5416
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0035 0.0634 0.1352
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0481 0.0982
Trypanosoma cruzi RNA polymerase IIA largest subunit, putative 0.0106 0.2313 0.5416
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1399 0.1399
Trichomonas vaginalis DNA-directed RNA polymerase I largest subunit, putative 0.0106 0.2313 0.5238
Toxoplasma gondii DNA-directed RNA polymerase I RPA1 0.0211 0.4768 1
Trypanosoma cruzi DNA-directed rna polymerase I largest subunit, putative 0.0017 0.023 0.0374
Trichomonas vaginalis DNA-directed RNA polymerase III largest subunit, putative 0.0024 0.0383 0.0386
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.1333 0.3045
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0481 0.0961
Toxoplasma gondii peptidylprolyl isomerase 0.0035 0.0634 0.1191
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0537 0.108
Schistosoma mansoni smad1 5 8 and 0.0009 0.0025 0.0025
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.1333 0.5221
Entamoeba histolytica DNA-directed RNA polymerase II large subunit, putative 0.0106 0.2313 0.4062
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.2793 0.5836
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.1176 0.2346
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0035 0.0654 0.1326
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.1333 0.1333
Echinococcus granulosus DNA directed RNA polymerase I subunit RPA1 0.0187 0.4207 0.4207
Trypanosoma brucei DNA-directed RNA polymerase II subunit RPB1 0.0106 0.2313 0.5416
Schistosoma mansoni cytochrome P450 0.0019 0.0263 0.0263
Echinococcus granulosus tar DNA binding protein 0.0067 0.1399 0.1399
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.1212 0.2503
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.1338 0.1338
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1399 0.1399
Leishmania major DNA-directed rna polymerase I largest subunit, putative 0.0187 0.4207 1
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.1333 0.1333
Schistosoma mansoni cpg binding protein 0.0032 0.0578 0.0578
Echinococcus granulosus cytochrome P450 2K1 0.0019 0.0263 0.0263
Toxoplasma gondii DNA-directed RNA polymerase III RPC1 0.0106 0.2313 0.4769
Schistosoma mansoni rotamase 0.0035 0.0654 0.0654
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.1333 0.5221
Leishmania major RNA polymerase ii largest subunit 0.0106 0.2313 0.5416
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0481 0.0961
Echinococcus granulosus cpg binding protein 0.0032 0.0578 0.0578
Echinococcus multilocularis DNA directed RNA polymerase II subunit 0.0106 0.2313 0.2313
Plasmodium falciparum RNA polymerase beta subunit, putative 0.0043 0.083 0.1323
Trichomonas vaginalis DNA-directed RNA polymerase I largest subunit, putative 0.0106 0.2313 0.5238
Wolbachia endosymbiont of Brugia malayi DNA-directed RNA polymerase subunit beta/beta' 0.0106 0.2313 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0044 0.0044
Trichomonas vaginalis RNA polymerase A, putative 0.0187 0.4207 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0025 0.0025
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.1333 1
Plasmodium vivax DNA-directed RNA polymerase I 190 kDa polypeptide, putative 0.0211 0.4768 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.0263 0.0454
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.1333 0.5221
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.1333 0.1333
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0044 0.0039
Loa Loa (eye worm) TAR-binding protein 0.0067 0.1399 0.2896
Plasmodium falciparum DNA-directed RNA polymerase II subunit RPB1 0.0106 0.2313 0.4591
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0481 0.0982
Trypanosoma brucei DNA-directed rna polymerase I largest subunit, putative 0.0187 0.4207 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.0263 0.0454
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0634 0.1352
Chlamydia trachomatis DNA-directed RNA polymerase subunit beta' 0.0106 0.2313 0.5
Brugia malayi RNA polymerase Rpb1, domain 2 family protein 0.0211 0.4768 1
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1399 0.1399
Schistosoma mansoni RNA polymerase Rpb1 0.0106 0.2313 0.2313
Brugia malayi Cytochrome P450 family protein 0.0028 0.0481 0.0961
Trypanosoma cruzi DNA-directed rna polymerase I largest subunit, putative 0.0187 0.4207 1
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.1333 0.1333
Toxoplasma gondii cytochrome p450 superfamily protein 0.0019 0.0263 0.04
Trypanosoma brucei DNA-directed RNA polymerase I largest subunit 0.0187 0.4207 1
Brugia malayi RNA polymerase Rpb1, domain 1 family protein 0.0106 0.2313 0.4825
Schistosoma mansoni hypothetical protein 0.0019 0.0263 0.0263
Plasmodium falciparum DNA-directed RNA polymerase III subunit RPC1, putative 0.0106 0.2313 0.4591
Brugia malayi cytochrome P450 0.0019 0.0263 0.0502
Plasmodium falciparum RNA polymerase I 0.0211 0.4768 1
Leishmania major cytochrome p450-like protein 0.0019 0.0263 0.0454
Trichomonas vaginalis rotamase, putative 0.0035 0.0654 0.1066
Brugia malayi CXXC zinc finger family protein 0.003 0.0537 0.108
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.1333 0.2681
Leishmania major cytochrome p450-like protein 0.0028 0.0481 0.0982
Echinococcus granulosus expressed protein 0.0035 0.0654 0.0654
Schistosoma mansoni cpg binding protein 0.003 0.0537 0.0537
Trypanosoma brucei RNA polymerase IIA largest subunit, putative 0.0017 0.023 0.0374
Echinococcus granulosus DNA directed RNA polymerase III subunit RPC1 0.0106 0.2313 0.2313
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0654 0.1066
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0025 0.0025
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.1399 0.2896
Echinococcus multilocularis dnaJ subfamily B 0.0433 1 1
Schistosoma mansoni cpg binding protein 0.0032 0.0578 0.0578
Schistosoma mansoni DNA-directed RNA polymerase I 0.0211 0.4768 0.4768
Mycobacterium ulcerans DNA-directed RNA polymerase subunit beta' 0.0106 0.2313 1
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0019 0.0263 0.0454
Entamoeba histolytica DNA-directed RNA polymerase I largest subunit, putative 0.0211 0.4768 1
Loa Loa (eye worm) DNA-directed RNA polymerase II largest subunit 0.0106 0.2313 0.4825
Onchocerca volvulus 0.003 0.0537 0.5
Echinococcus multilocularis expressed protein 0.0035 0.0654 0.0654
Loa Loa (eye worm) CYP4Cod1 0.0028 0.0481 0.0961
Trypanosoma cruzi RNA polymerase IIA largest subunit, putative 0.0017 0.023 0.0374
Loa Loa (eye worm) RNA binding protein 0.0067 0.1399 0.2896
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0019 0.0263 0.0454
Brugia malayi Cytochrome P450 family protein 0.0019 0.0263 0.0502
Brugia malayi RNA binding protein 0.0067 0.1399 0.2896
Echinococcus multilocularis DNA directed RNA polymerase II subunit RPB1 0.0024 0.0383 0.0383
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0025 0.0025
Echinococcus granulosus smad 0.0009 0.0025 0.0025
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1399 0.1399
Trypanosoma brucei cytochrome P450, putative 0.0028 0.0481 0.0982
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0019 0.0263 0.0454
Toxoplasma gondii DNA-directed RNA polymerase, putative 0.0017 0.023 0.0329
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.1399 0.2896
Echinococcus multilocularis smad 0.0009 0.0025 0.0025
Leishmania major cytochrome p450-like protein 0.0019 0.0263 0.0454
Echinococcus multilocularis tar DNA binding protein 0.0067 0.1399 0.1399
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0634 0.1352
Trypanosoma cruzi DNA-directed RNA polymerase III subunit C1, putative 0.0106 0.2313 0.5416
Brugia malayi DNA-directed RNA polymerase II largest subunit, putative 0.0106 0.2313 0.4825
Toxoplasma gondii RNA polymerase C2, putative 0.0041 0.0781 0.1504
Echinococcus granulosus Smad4 0.0009 0.0025 0.0025
Echinococcus multilocularis DNA directed RNA polymerase I subunit RPA1 0.0187 0.4207 0.4207
Brugia malayi Cytochrome P450 family protein 0.0059 0.1212 0.2503
Leishmania major DNA-directed RNA polymerase III largest subunit , putative 0.0106 0.2313 0.5416
Trichomonas vaginalis DNA-directed RNA polymerase, putative 0.0043 0.083 0.151
Brugia malayi Cytochrome P450 family protein 0.0028 0.0481 0.0961
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0028 0.0481 0.1063
Echinococcus multilocularis DNA directed RNA polymerase III subunit RPC1 0.0106 0.2313 0.2313
Mycobacterium leprae DNA-DIRECTED RNA POLYMERASE (BETA' CHAIN) RPOC (TRANSCRIPTASE BETA' CHAIN) (RNA POLYMERASE BETA' SUBUNIT). 0.0106 0.2313 1
Echinococcus granulosus DNA directed RNA polymerase II subunit 0.0106 0.2313 0.2313

Activities

Activity type Activity value Assay description Source Reference
Contraction (functional) % Agonism of Muscarinic acetylcholine receptor M3 was determined as maximal contraction rate of isolated guinea pig ileum ChEMBL. 15149637
Contraction (functional) 0 % Agonism of Muscarinic acetylcholine receptor M3 was determined as maximal contraction rate of isolated guinea pig ileum ChEMBL. 15149637
Relaxation (functional) = 30 % Agonism of endothelin A receptor was determined as maximal rate of vascular endothelium-dependent relaxation at the concentration of 10E-5 M/L; 20-30% ChEMBL. 15149637
Relaxation (functional) = 30 % Agonism of endothelin A receptor was determined as maximal rate of vascular endothelium-dependent relaxation at the concentration of 10E-5 M/L; 20-30% ChEMBL. 15149637

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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