Detailed information for compound 1712034

Basic information

Technical information
  • TDR Targets ID: 1712034
  • Name: 2,3-di(phenyl)piperazine
  • MW: 238.328 | Formula: C16H18N2
  • H donors: 2 H acceptors: 0 LogP: 2.2 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: C1CNC(C(N1)c1ccccc1)c1ccccc1
  • InChi: 1S/C16H18N2/c1-3-7-13(8-4-1)15-16(18-12-11-17-15)14-9-5-2-6-10-14/h1-10,15-18H,11-12H2
  • InChiKey: NXYCTQXWYWRZDE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • GL-0153
  • NSC15530

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0053 0.0328 0.1205
Loa Loa (eye worm) hypothetical protein 0.0029 0.0116 0.0436
Trypanosoma brucei unspecified product 0.0025 0.0078 0.0252
Plasmodium falciparum transporter, putative 0.005 0.0294 0.1076
Trypanosoma cruzi DNA polymerase kappa, putative 0.0053 0.0328 0.1205
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.005 0.0294 0.1187
Echinococcus multilocularis divalent metal transporter DMT1B 0.0038 0.0192 0.0735
Echinococcus multilocularis dna polymerase kappa 0.0053 0.0328 0.1311
Loa Loa (eye worm) hypothetical protein 0.005 0.0294 0.1187
Trichomonas vaginalis CAMK family protein kinase 0.0063 0.0414 1
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.005 0.0294 0.1169
Trichomonas vaginalis CAMK family protein kinase 0.0063 0.0414 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0053 0.0328 0.1205
Entamoeba histolytica serine/threonine protein kinase, putative 0.0063 0.0414 1
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0137 0.3028
Loa Loa (eye worm) hypothetical protein 0.005 0.0294 0.1187
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0117 0.0398
Brugia malayi hypothetical protein 0.0024 0.0075 0.0087
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0117 0.0398
Brugia malayi Calcitonin receptor-like protein seb-1 0.0033 0.0155 0.0198
Schistosoma mansoni hypothetical protein 0.0114 0.0849 0.3546
Trypanosoma brucei DNA polymerase IV, putative 0.0053 0.0328 0.1205
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.005 0.0294 0.1223
Brugia malayi MH2 domain containing protein 0.0199 0.1586 0.218
Echinococcus granulosus geminin 0.0114 0.0849 0.3507
Echinococcus multilocularis sodium and chloride dependent glycine 0.005 0.0294 0.1169
Loa Loa (eye worm) hypothetical protein 0.0053 0.0322 0.1302
Schistosoma mansoni sodium/chloride dependent transporter 0.005 0.0294 0.1223
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.005 0.0294 0.1118
Entamoeba histolytica hypothetical protein 0.0024 0.0075 0.1452
Trichomonas vaginalis DNA polymerase eta, putative 0.0053 0.0328 0.7837
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0063 0.0414 0.1673
Loa Loa (eye worm) hypothetical protein 0.0292 0.2389 1
Onchocerca volvulus 0.005 0.0294 0.0105
Echinococcus multilocularis geminin 0.0114 0.0849 0.3507
Schistosoma mansoni DNA polymerase eta 0.0053 0.0322 0.1337
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.005 0.0294 0.1187
Mycobacterium ulcerans DNA polymerase IV 0.0053 0.0328 1
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0017 0.0017 0.0018
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0036 0.0174 0.0661
Brugia malayi polk-prov protein 0.0029 0.0116 0.0143
Trypanosoma brucei DNA polymerase kappa, putative 0.0053 0.0328 0.1205
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.005 0.0294 0.1223
Trichomonas vaginalis CAMK family protein kinase 0.0063 0.0414 1
Entamoeba histolytica hypothetical protein 0.0024 0.0075 0.1452
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0033 0.0155 0.0198
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0047 0.027 0.1064
Toxoplasma gondii hypothetical protein 0.005 0.0294 0.1118
Plasmodium falciparum flap endonuclease 1 0.0017 0.0017 0.0018
Loa Loa (eye worm) hypothetical protein 0.0023 0.0064 0.0216
Brugia malayi hypothetical protein 0.005 0.0294 0.0391
Schistosoma mansoni hypothetical protein 0.0023 0.0064 0.0256
Trypanosoma brucei DNA polymerase IV, putative 0.0053 0.0328 0.1205
Echinococcus granulosus serotonin transporter 0.0292 0.2389 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0031 0.0131 0.054
Schistosoma mansoni divalent metal transporter DMT1B 0.0038 0.0192 0.0792
Echinococcus granulosus uncharacterized sodium dependent transporter 0.005 0.0294 0.1169
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0031 0.0131 0.0482
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0193 0.0689
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0137 0.3028
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0193 0.4428
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0212 0.0762
Plasmodium vivax telomerase reverse transcriptase, putative 0.032 0.2634 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0212 0.0762
Giardia lamblia Telomerase catalytic subunit 0.032 0.2634 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0294 0.1187
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0193 0.0732
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0063 0.0414 0.169
Loa Loa (eye worm) MH2 domain-containing protein 0.0199 0.1586 0.6621
Giardia lamblia Kinase, PLK 0.0063 0.0414 0.1516
Trypanosoma brucei DNA polymerase IV, putative 0.0049 0.029 0.1059
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.005 0.0294 0.0391
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0033 0.0155 0.0601
Treponema pallidum sodium- and chloride- dependent transporter 0.0292 0.2389 0.5
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.005 0.0294 0.1169
Loa Loa (eye worm) hypothetical protein 0.0038 0.0192 0.0754
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0193 0.0689
Loa Loa (eye worm) hypothetical protein 0.0292 0.2389 1
Schistosoma mansoni transcription factor LCR-F1 0.0024 0.0075 0.0302
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0036 0.0174 0.0661
Toxoplasma gondii hypothetical protein 0.005 0.0294 0.1118
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0159 1
Loa Loa (eye worm) flap endonuclease-1 0.0017 0.0017 0.002
Trichomonas vaginalis hypothetical protein 0.0023 0.0063 0.1144
Trypanosoma cruzi DNA polymerase kappa, putative 0.0053 0.0328 0.1205
Onchocerca volvulus 0.005 0.0294 0.0105
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0031 0.0131 0.0482
Toxoplasma gondii divalent metal transporter, putative 0.0038 0.0192 0.0728
Brugia malayi Telomerase reverse transcriptase 0.0853 0.7232 1
Brugia malayi hypothetical protein 0.0203 0.1619 0.2225
Leishmania major DNA polymerase eta, putative 0.0028 0.0109 0.037
Leishmania major telomerase reverse transcriptase, putative 0.032 0.2634 1
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.005 0.0294 0.1169
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.005 0.0294 0.1223
Echinococcus granulosus dna polymerase eta 0.0053 0.0322 0.1284
Brugia malayi latrophilin 2 splice variant baaae 0.0023 0.0064 0.0071
Echinococcus granulosus sodium and chloride dependent glycine 0.005 0.0294 0.1169
Plasmodium vivax metal transporter, putative 0.0038 0.0192 0.0684
Loa Loa (eye worm) transcription factor SMAD2 0.0199 0.1586 0.6621
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0193 0.4428
Trichomonas vaginalis CAMK family protein kinase 0.0063 0.0414 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0116 0.0395
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0193 0.4428
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.005 0.0294 0.1169
Onchocerca volvulus Serine\/threonine kinase homolog 0.0063 0.0414 0.0227
Schistosoma mansoni kinase 0.0032 0.0145 0.0595
Trypanosoma brucei DNA polymerase kappa, putative 0.0053 0.0328 0.1205
Schistosoma mansoni tsg101-related 0.0032 0.0141 0.0577
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.005 0.0294 0.1223
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0193 0.4428
Plasmodium falciparum amino acid transporter, putative 0.005 0.0294 0.1076
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0193 0.0689
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0031 0.0131 0.054
Loa Loa (eye worm) inositol-1 0.0038 0.0193 0.076
Brugia malayi Sodium:neurotransmitter symporter family protein 0.005 0.0294 0.0391
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0292 0.2389 1
Brugia malayi Flap endonuclease-1 0.0017 0.0017 0.0007
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0053 0.0328 0.7837
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.005 0.0294 0.1118
Mycobacterium tuberculosis Conserved hypothetical protein 0.0036 0.0174 0.7359
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0036 0.0174 0.068
Leishmania major DNA polymerase kappa, putative 0.004 0.0212 0.0762
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.005 0.0294 0.1223
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0292 0.2389 0.3292
Brugia malayi hypothetical protein 0.0047 0.027 0.0356
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.005 0.0294 0.1118
Echinococcus multilocularis dna polymerase eta 0.0053 0.0322 0.1284
Trypanosoma cruzi DNA polymerase kappa, putative 0.0053 0.0328 0.1205
Trypanosoma brucei unspecified product 0.0049 0.029 0.1059
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0017 0.0017 0.0065
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0024 0.0075 0.0243
Schistosoma mansoni divalent metal transporter DMT1B 0.0038 0.0192 0.0792
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0036 0.0174 0.0718
Schistosoma mansoni terminal deoxycytidyl transferase 0.0036 0.0174 0.0718
Trypanosoma brucei polo-like protein kinase 0.0063 0.0414 0.1532
Brugia malayi Sodium:neurotransmitter symporter family protein 0.005 0.0294 0.0391
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0193 0.0689
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0193 0.0741
Loa Loa (eye worm) hypothetical protein 0.0033 0.0155 0.0601
Loa Loa (eye worm) solute carrier family 6 member 4 0.0292 0.2389 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.005 0.0294 0.1169
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0024 0.0075 0.0243
Schistosoma mansoni sodium/chloride dependent transporter 0.005 0.0296 0.123
Onchocerca volvulus 0.0292 0.2389 0.224
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0031 0.0131 0.054
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0031 0.0131 0.0482
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0063 0.0414 0.1532
Trichomonas vaginalis CAMK family protein kinase 0.0063 0.0414 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.0212 1
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.032 0.2634 1
Schistosoma mansoni inositol monophosphatase 0.0038 0.0193 0.0797
Onchocerca volvulus 0.005 0.0294 0.0105
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.005 0.0294 0.1223
Trypanosoma cruzi polo-like protein kinase, putative 0.0063 0.0414 0.1532
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.005 0.0294 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0053 0.0328 0.1205
Brugia malayi ImpB/MucB/SamB family protein 0.0036 0.0174 0.0224
Trypanosoma brucei unspecified product 0.0025 0.0078 0.0252
Trypanosoma brucei DNA polymerase kappa, putative 0.0053 0.0328 0.1205
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0028 0.0109 0.0416
Loa Loa (eye worm) hypothetical protein 0.005 0.0294 0.1187
Loa Loa (eye worm) hypothetical protein 0.0292 0.2389 1
Echinococcus granulosus sodium and chloride dependent glycine 0.005 0.0294 0.1169
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.005 0.0294 0.1223
Plasmodium vivax hypothetical protein, conserved 0.005 0.0294 0.1076
Loa Loa (eye worm) hypothetical protein 0.0203 0.1619 0.676
Trichomonas vaginalis CAMK family protein kinase 0.0063 0.0414 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0193 0.5
Plasmodium vivax amine transporter, putative 0.005 0.0294 0.1076
Trypanosoma cruzi polo-like protein kinase, putative 0.0063 0.0414 0.1532
Brugia malayi Inositol-1 0.0038 0.0193 0.025
Onchocerca volvulus 0.0203 0.1619 0.1455
Loa Loa (eye worm) serotonin transporter b 0.0292 0.2389 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0053 0.0328 0.1205
Schistosoma mansoni sodium-dependent amino acid transporter 0.005 0.0294 0.1223
Brugia malayi NRAMP-like transporter K11G12.4 0.0038 0.0192 0.0248
Entamoeba histolytica hypothetical protein 0.0024 0.0075 0.1452
Entamoeba histolytica hypothetical protein 0.0024 0.0075 0.1452
Toxoplasma gondii RNA-directed DNA polymerase 0.032 0.2634 1
Echinococcus multilocularis sodium and chloride dependent glycine 0.005 0.0294 0.1169
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0047 0.027 0.1064
Plasmodium falciparum telomerase reverse transcriptase 0.032 0.2634 1
Echinococcus granulosus divalent metal transporter DMT1B 0.0038 0.0192 0.0735
Loa Loa (eye worm) hypothetical protein 0.0038 0.0192 0.0754
Echinococcus granulosus dna polymerase kappa 0.0053 0.0328 0.1311
Plasmodium vivax flap endonuclease 1, putative 0.0017 0.0017 0.0018
Echinococcus multilocularis serotonin transporter 0.0292 0.2389 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0159 0.6304
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0031 0.0131 0.0165
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0193 0.0095
Loa Loa (eye worm) hypothetical protein 0.005 0.0294 0.1187
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0017 0.0017 0.0018
Brugia malayi Sodium:neurotransmitter symporter family protein 0.005 0.0294 0.0391
Trypanosoma brucei DNA polymerase eta, putative 0.0053 0.0322 0.118
Schistosoma mansoni tsg101-related 0.0039 0.0202 0.0835
Loa Loa (eye worm) norepinephrine transporter 0.0292 0.2389 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0063 0.0414 0.0556
Loa Loa (eye worm) hypothetical protein 0.0047 0.027 0.1082
Trypanosoma brucei DNA polymerase kappa, putative 0.0053 0.0328 0.1205
Schistosoma mansoni inositol monophosphatase 0.0038 0.0193 0.0797
Entamoeba histolytica deoxycytidyl transferase, putative 0.0036 0.0174 0.3951
Trypanosoma brucei telomerase reverse transcriptase 0.032 0.2634 1
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0017 0.0017 0.0018
Schistosoma mansoni hypothetical protein 0.0114 0.0849 0.3546
Plasmodium falciparum transporter, putative 0.0038 0.0192 0.0684
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0031 0.0131 0.0482
Schistosoma mansoni hypothetical protein 0.0024 0.0075 0.0302
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.005 0.0294 0.1169
Leishmania major DNA polymerase eta, putative 0.0053 0.0322 0.118
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0117 0.0398
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.032 0.2634 1
Mycobacterium ulcerans DNA polymerase IV 0.0053 0.0328 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0294 0.1187
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0116 0.0395
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.005 0.0294 0.1223
Brugia malayi ImpB/MucB/SamB family protein 0.0053 0.0322 0.0428
Schistosoma mansoni tsg101-related 0.0039 0.0202 0.0835
Loa Loa (eye worm) hypothetical protein 0.005 0.0294 0.1187
Trypanosoma brucei DNA polymerase kappa, putative 0.0053 0.0328 0.1205
Trypanosoma cruzi DNA polymerase eta, putative 0.0028 0.0109 0.037
Schistosoma mansoni sodium/chloride dependent transporter 0.0292 0.2389 1
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0032 0.0141 0.3107
Trichomonas vaginalis CAMK family protein kinase 0.0063 0.0414 1
Giardia lamblia DINP protein human, muc B family 0.004 0.0212 0.0745
Toxoplasma gondii LsmAD domain-containing protein 0.0017 0.0012 0.0047
Trypanosoma cruzi DNA polymerase eta, putative 0.0053 0.0322 0.118
Trypanosoma cruzi DNA polymerase kappa, putative 0.0053 0.0328 0.1205
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.0414 0.1724
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0063 0.0414 0.1673
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0031 0.0131 0.0501
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0193 0.0741

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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