Detailed information for compound 1715588

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 457.567 | Formula: C27H31N5O2
  • H donors: 1 H acceptors: 2 LogP: 3.21 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCN(CC1)c1ccc2cc1COCC=CCOCc1cc(c3nc(N2)ncc3)ccc1
  • InChi: 1S/C27H31N5O2/c1-31-11-13-32(14-12-31)26-8-7-24-18-23(26)20-34-16-3-2-15-33-19-21-5-4-6-22(17-21)25-9-10-28-27(29-24)30-25/h2-10,17-18H,11-16,19-20H2,1H3,(H,28,29,30)
  • InChiKey: VWXMOLWJXUSYOA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens fms-related tyrosine kinase 3 Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 3 References
Homo sapiens cyclin A2 References
Homo sapiens Janus kinase 2 Starlite/ChEMBL References
Homo sapiens cyclin A1 Starlite/ChEMBL References
Homo sapiens tyrosine kinase 2 Starlite/ChEMBL References
Homo sapiens Janus kinase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin A, putative Get druggable targets OG5_126649 All targets in OG5_126649
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis mitotic cyclin-CYC2 Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cyclin 6,mitotic cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia G2/mitotic-specific cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0053 0.0118
Schistosoma mansoni cell adhesion molecule 0.0019 0.0006 0.0078
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0053 0.0118
Brugia malayi Cyclin, N-terminal domain containing protein 0.0038 0.0075 0.0075
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0019 0.0006 0.0006
Echinococcus multilocularis neuroglian 0.0019 0.0006 0.0013
Brugia malayi Immunoglobulin I-set domain containing protein 0.003 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0019 0.0006 0.0006
Brugia malayi Protein kinase domain containing protein 0.0052 0.013 0.013
Schistosoma mansoni coup transcription factor 0.0031 0.0053 0.0688
Trypanosoma cruzi carnitine O-acetyltransferase, putative 0.0224 0.0767 0.1471
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0053 0.0688
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0053 0.0053
Trichomonas vaginalis cyclins, putative 0.009 0.027 1
Brugia malayi Fibronectin type III domain containing protein 0.0019 0.0006 0.0006
Loa Loa (eye worm) carnitine O-palmitoyltransferase I isoform 0.0224 0.0767 0.0767
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0053 0.0053
Trypanosoma cruzi hypothetical protein, conserved 0.0224 0.0767 0.1471
Onchocerca volvulus 0.0224 0.0767 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0006 0.0006
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0053 0.0118
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0053 0.0053
Trichomonas vaginalis cyclin B, putative 0.009 0.027 1
Giardia lamblia Kinase, CMGC CDK 0.0052 0.013 0.2782
Loa Loa (eye worm) choline O-acetyltransferase 0.0224 0.0767 0.0767
Plasmodium falciparum protein kinase 5 0.0052 0.013 1
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0053 0.0688
Schistosoma mansoni cyclin B 0.009 0.027 0.3517
Trypanosoma cruzi choline/carnitine O-acetyltransferase, putative 0.0224 0.0767 0.1471
Echinococcus multilocularis cyclin dependent kinase 0.0052 0.013 0.029
Trypanosoma cruzi hypothetical protein, conserved 0.0224 0.0767 0.1471
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.1223 0.4465 1
Plasmodium vivax protein kinase Crk2 0.0052 0.013 0.5
Brugia malayi nuclear receptor NHR-88 0.0031 0.0053 0.0053
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0224 0.0767 1
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0053 0.0688
Brugia malayi Cyclin, N-terminal domain containing protein 0.009 0.027 0.027
Trypanosoma cruzi CYC2-like cyclin, putative 0.009 0.027 0.0323
Entamoeba histolytica cyclin, putative 0.0038 0.0075 0.2798
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0053 0.0118
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.013 0.2782
Loa Loa (eye worm) hypothetical protein 0.009 0.027 0.027
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.1223 0.4465 1
Trypanosoma brucei carnitine O-acetyltransferase, putative 0.0224 0.0767 1
Brugia malayi Choline O-acetyltransferase 0.0224 0.0767 0.0767
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0019 0.0006 0.0006
Entamoeba histolytica cyclin family protein 0.0038 0.0075 0.2798
Schistosoma mansoni choline o-acyltransferase 0.0224 0.0767 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0053 0.0053
Echinococcus granulosus cyclins 0.0038 0.0075 0.0169
Echinococcus granulosus cyclins 0.0038 0.0075 0.0169
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0053 0.0688
Loa Loa (eye worm) hypothetical protein 0.0019 0.0006 0.0006
Trypanosoma cruzi cyclin 6, putative 0.009 0.027 0.0323
Leishmania major choline/Carnitine o-acyltransferase-like protein 0.1223 0.4465 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0053 0.0053
Schistosoma mansoni vesicular amine transporter 0.0019 0.0006 0.0078
Echinococcus multilocularis carnitine O palmitoyltransferase 1, liver 0.1223 0.4465 1
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0224 0.0767 0.0767
Trypanosoma brucei hypothetical protein, conserved 0.0224 0.0767 1
Echinococcus multilocularis cyclins 0.0038 0.0075 0.0169
Entamoeba histolytica cyclin family protein 0.0038 0.0075 0.2798
Loa Loa (eye worm) hypothetical protein 0.0031 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0019 0.0006 0.0006
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0053 0.0688
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0053 0.0118
Trichomonas vaginalis cyclins, putative 0.0062 0.0164 0.4577
Echinococcus granulosus cyclin dependent kinase 0.0052 0.013 0.029
Loa Loa (eye worm) TK/KIN16 protein kinase 0.003 0.0047 0.0047
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0053 0.0118
Brugia malayi cell division control protein 2 homolog 0.0052 0.013 0.013
Echinococcus granulosus cyclin B3 1 0.0038 0.0075 0.0169
Trypanosoma cruzi cyclin, putative 0.009 0.027 0.0323
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.013 0.2782
Trypanosoma brucei carnitine O-palmitoyltransferase, putative 0.0224 0.0767 1
Echinococcus multilocularis cyclins 0.0038 0.0075 0.0169
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0053 0.0053
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0038 0.0075 0.0169
Leishmania major carnitine palmitoyltransferase-like protein 0.0224 0.0767 0.1471
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0019 0.0006 0.0006
Echinococcus granulosus choline O acetyltransferase 0.0224 0.0767 0.1718
Loa Loa (eye worm) hypothetical protein 0.0224 0.0767 0.0767
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.009 0.027 0.0323
Echinococcus multilocularis Immunoglobulin 0.0019 0.0006 0.0013
Trypanosoma cruzi hypothetical protein, conserved 0.0224 0.0767 0.1471
Loa Loa (eye worm) hypothetical protein 0.2718 1 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0053 0.0688
Trichomonas vaginalis cyclin B, putative 0.009 0.027 1
Echinococcus granulosus carnitine O palmitoyltransferase 2 0.0224 0.0767 0.1718
Loa Loa (eye worm) hypothetical protein 0.0019 0.0006 0.0006
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0053 0.0053
Trichomonas vaginalis cyclin A, putative 0.009 0.027 1
Brugia malayi nuclear hormone receptor 0.0031 0.0053 0.0053
Trypanosoma brucei mitotic cyclin 6 0.009 0.027 0.22
Trichomonas vaginalis cyclins, putative 0.009 0.027 1
Loa Loa (eye worm) choline/Carnitine O-acyltransferase 0.0224 0.0767 0.0767
Leishmania major cyclin 0.009 0.027 0.0323
Echinococcus granulosus cyclin B 0.009 0.027 0.0604
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0019 0.0006 0.0078
Brugia malayi Cyclin, N-terminal domain containing protein 0.009 0.027 0.027
Trypanosoma cruzi cyclin, putative 0.009 0.027 0.0323
Echinococcus multilocularis cyclin B 0.009 0.027 0.0604
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0053 0.0118
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0053 0.0118
Loa Loa (eye worm) hypothetical protein 0.0031 0.0053 0.0053
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0053 0.0688
Echinococcus granulosus carnitine O palmitoyltransferase 1 liver 0.1223 0.4465 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0053 0.0118
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0053 0.0053
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0006 0.0006
Trichomonas vaginalis cyclins, putative 0.009 0.027 1
Echinococcus granulosus twitchin 0.0019 0.0008 0.0018
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0052 0.013 0.013
Entamoeba histolytica cyclin, putative 0.009 0.027 1
Echinococcus multilocularis cyclins 0.0038 0.0075 0.0169
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0053 0.0688
Loa Loa (eye worm) hypothetical protein 0.0052 0.0127 0.0127
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0019 0.0006 0.0013
Echinococcus granulosus defective proboscis extension response 0.0019 0.0006 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0053 0.0053
Leishmania major carnitine/choline acetyltransferase, putative 0.0224 0.0767 0.1471
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0053 0.0688
Echinococcus granulosus tyrosine protein kinase Lyn 0.0018 0.0002 0.0005
Trichomonas vaginalis cyclin B, putative 0.009 0.027 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0053 0.0053
Onchocerca volvulus 0.0224 0.0767 1
Echinococcus granulosus cyclins 0.0038 0.0075 0.0169
Schistosoma mansoni nephrin 0.0019 0.0006 0.0078
Echinococcus granulosus cyclins 0.0038 0.0075 0.0169
Echinococcus granulosus roundabout 2 0.0019 0.0006 0.0013
Schistosoma mansoni choline o-acyltransferase 0.0224 0.0767 1
Brugia malayi ecdysteroid receptor 0.0031 0.0053 0.0053
Giardia lamblia Kinase, CMGC CDK 0.0052 0.013 0.2782
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0052 0.0131 0.0131
Echinococcus granulosus cyclins 0.0038 0.0075 0.0169
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0053 0.0118
Trypanosoma cruzi hypothetical protein, conserved 0.0224 0.0767 0.1471
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0053 0.0118
Echinococcus granulosus cyclin dependent kinase 1 0.0052 0.013 0.029
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0053 0.0118
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0053 0.0688
Echinococcus multilocularis cyclin b3 0.0038 0.0075 0.0169
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0052 0.013 0.029
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0019 0.0006 0.0013
Loa Loa (eye worm) hypothetical protein 0.0031 0.0053 0.0053
Onchocerca volvulus 0.0031 0.0053 0.0688
Entamoeba histolytica cell division protein kinase 2, putative 0.0052 0.013 0.4802
Brugia malayi Choline O-acetyltransferase 0.0224 0.0767 0.0767
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0053 0.0688
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0053 0.0053
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.013 0.1689
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0053 0.0053
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.0224 0.0767 0.1471
Brugia malayi hypothetical protein 0.0019 0.0006 0.0006
Echinococcus multilocularis cyclins 0.0038 0.0075 0.0169
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0053 0.0118
Onchocerca volvulus 0.0224 0.0767 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0053 0.0053
Schistosoma mansoni cyclins 0.0038 0.0075 0.0984
Trichomonas vaginalis cyclins, putative 0.009 0.027 1
Entamoeba histolytica cell division protein kinase 2, putative 0.0052 0.013 0.4802
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0053 0.0053
Trichomonas vaginalis cyclin B, putative 0.009 0.027 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0053 0.0053
Onchocerca volvulus 0.009 0.027 0.3517
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0052 0.013 1
Echinococcus multilocularis choline O acetyltransferase 0.0224 0.0767 0.1718
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.013 0.2782
Echinococcus granulosus Immunoglobulin 0.0019 0.0006 0.0013
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0052 0.013 0.013
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0053 0.0053
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0053 0.0118
Loa Loa (eye worm) cyclin domain-containing protein 0.0038 0.0075 0.0075
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.0224 0.0767 0.1471
Echinococcus multilocularis cyclin dependent kinase 5 0.0052 0.013 0.029
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0224 0.0767 0.0767
Loa Loa (eye worm) hypothetical protein 0.0019 0.0006 0.0006
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0224 0.0767 0.1471
Echinococcus multilocularis cyclin B3 1 0.0038 0.0075 0.0169
Loa Loa (eye worm) hypothetical protein 0.009 0.027 0.027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0053 0.0053
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0053 0.0688
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0019 0.0006 0.0078
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0053 0.0053
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0052 0.013 0.013
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0053 0.0118
Echinococcus granulosus neuroglian 0.0019 0.0006 0.0013
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0053 0.0118
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0053 0.0118
Schistosoma mansoni cyclin B3 0.0038 0.0075 0.0984
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0224 0.0767 1
Echinococcus granulosus cyclin dependent kinase 5 0.0052 0.013 0.029
Loa Loa (eye worm) hypothetical protein 0.0031 0.0053 0.0053
Brugia malayi steroid hormone receptor 0.0031 0.0053 0.0053
Echinococcus multilocularis Immunoglobulin 0.0019 0.0006 0.0013
Giardia lamblia G2/mitotic-specific cyclin B 0.009 0.027 1
Echinococcus multilocularis cyclin dependent kinase 1 0.0052 0.013 0.029
Loa Loa (eye worm) hypothetical protein 0.0031 0.0053 0.0053
Trypanosoma cruzi carnitine O-palmitoyltransferase II, putative 0.0224 0.0767 0.1471
Echinococcus multilocularis cyclins 0.0038 0.0075 0.0169
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0053 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0053 0.0053
Echinococcus granulosus cyclin b3 0.0038 0.0075 0.0169
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0053 0.0688
Echinococcus multilocularis cyclins 0.0038 0.0075 0.0169
Onchocerca volvulus 0.0224 0.0767 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0053 0.0688
Echinococcus multilocularis roundabout 2 0.0019 0.0006 0.0013
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0053 0.0053
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0038 0.0075 0.0169
Echinococcus multilocularis carnitine O palmitoyltransferase 2 0.0224 0.0767 0.1718
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.013 0.1689
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0053 0.0053
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0053 0.0688
Trypanosoma cruzi hypothetical protein, conserved 0.0224 0.0767 0.1471
Loa Loa (eye worm) hypothetical protein 0.0031 0.0053 0.0053
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0053 0.0118
Echinococcus multilocularis cyclin dependent kinase 1 0.0052 0.013 0.029
Echinococcus multilocularis cyclins 0.0038 0.0075 0.0169

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) Inhibition of recombinant JAK3 using Poly (Glu,Ala,Tyr) as substrate after 2 hrs by luminescence assay ChEMBL. 21604762
IC50 (binding) = 0.03 uM Inhibition of recombinant FLT3 using Poly (Glu,Ala,Tyr) as substrate after 2 hrs by luminescence assay ChEMBL. 21604762
IC50 (binding) = 0.041 uM Inhibition of recombinant JAK2 using Poly (Glu,Ala,Tyr) as substrate after 2 hrs by luminescence assay ChEMBL. 21604762
IC50 (binding) = 0.19 uM Inhibition of recombinant TYK2 ChEMBL. 21604762
IC50 (binding) = 3.6 uM Inhibition of recombinant JAK1 using Poly (Glu,Ala,Tyr) as substrate after 2 hrs by luminescence assay ChEMBL. 21604762
IC50 (binding) > 10 uM Inhibition of recombinant CDK2/Cyclin A using RbinG as substrate after 2 hrs by luminescence assay ChEMBL. 21604762

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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