TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 553.157 | Formula: C26H35ClN3O4S2-
H donors: 4 H acceptors: 4 LogP: 2.64 Rotable bonds: 16
Rule of 5 violations (Lipinski): 2
SMILES: CSCC[C@H](C(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](C(C)C)NCc1ccccc1S.[Cl-]
InChi: 1S/C26H35N3O4S2.ClH/c1-17(2)23(27-16-19-11-7-8-12-22(19)34)25(31)29-21(15-18-9-5-4-6-10-18)24(30)28-20(26(32)33)13-14-35-3;/h4-12,17,20-21,23,27,34H,13-16H2,1-3H3,(H,28,30)(H,29,31)(H,32,33);1H/p-1/t20-,21-,23-;/m0./s1
InChiKey: DASSPKFKYKXRGA-XCZLHMEYSA-M

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	T-complex protein 1 beta subunit, putative	0.0027	0.0114	0.4558
Leishmania major	cathepsin L-like protease	0.0037	0.0223	0.0836
Echinococcus granulosus	Zinc finger RanBP2 type	0.0254	0.2634	0.2964
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0641	0.0827
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.006	0.0483	0.048
Toxoplasma gondii	ran binding protein	0.0254	0.2634	0.3396
Brugia malayi	brahma associated protein 60 kDa	0.0713	0.7748	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0037	0.0223	0.0288
Echinococcus multilocularis	microtubule associated protein 2	0.0815	0.8879	0.8878
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0087	0.0107
Echinococcus granulosus	GPCR family 2	0.0035	0.0195	0.0215
Toxoplasma gondii	cathepsin CPL	0.0037	0.0223	0.0284
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0223	0.0284
Echinococcus multilocularis	Upstream activation factor subunit UAF30	0.0713	0.7748	0.7747
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0037	0.0223	0.022
Entamoeba histolytica	cysteine proteinase, putative	0.0037	0.0223	1
Brugia malayi	exodeoxyribonuclease III family protein	0.0022	0.0057	0.0074
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0037	0.0223	0.0284
Trypanosoma cruzi	cysteine proteinase, putative	0.0019	0.0023	0.0074
Echinococcus multilocularis	Nuclear pore complex protein Nup153	0.0254	0.2634	0.2631
Trypanosoma cruzi	hypothetical protein, conserved	0.0254	0.2634	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.004	0.0254	0.0328
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0254	0.2634	0.3399
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.1384	0.525
Brugia malayi	Cytochrome P450 family protein	0.004	0.0254	0.0328
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0022	0.0057	0.0204
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.1384	0.525
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0019	0.0023	0.0022
Echinococcus multilocularis	musashi	0.0032	0.0165	0.0161
Trypanosoma cruzi	cytochrome P450, putative	0.004	0.0254	0.0954
Schistosoma mansoni	intermediate filament proteins	0.0032	0.0165	0.0181
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0254	0.2634	0.3399
Echinococcus granulosus	cathepsin l1	0.0025	0.0087	0.0094
Schistosoma mansoni	chaperonin containing t-complex protein 1 beta subunit tcpb	0.0027	0.0114	0.0125
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0022	0.0057	0.0061
Brugia malayi	intermediate filament protein	0.0032	0.0165	0.0212
Onchocerca volvulus		0.0037	0.0223	0.0178
Trypanosoma brucei	T-complex protein 1, beta subunit, putative	0.0027	0.0114	0.0421
Trichomonas vaginalis	chaperonin, putative	0.0027	0.0114	0.0143
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0223	0.0284
Trichomonas vaginalis	ap endonuclease, putative	0.0022	0.0057	0.0069
Echinococcus multilocularis	SWI:SNF matrix associated	0.0713	0.7748	0.7747
Echinococcus multilocularis	Zinc finger, RanBP2 type	0.0254	0.2634	0.2631
Trypanosoma cruzi	cysteine protease, putative	0.0019	0.0023	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0109	0.1025	0.1323
Leishmania major	cysteine peptidase A (CPA)	0.0037	0.0223	0.0836
Echinococcus multilocularis	lysine specific demethylase 5A	0.006	0.0483	0.048
Onchocerca volvulus		0.0051	0.0381	0.0384
Brugia malayi	Thioredoxin reductase	0.005	0.0368	0.0475
Echinococcus granulosus	lysine specific demethylase 5A	0.006	0.0483	0.054
Onchocerca volvulus		0.0037	0.0223	0.0178
Echinococcus granulosus	microtubule associated protein 2	0.0815	0.8879	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0109	0.1025	0.1323
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0114	0.1083	0.8837
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.1384	0.525
Schistosoma mansoni	hypothetical protein	0.0035	0.0195	0.0215
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0037	0.0223	0.0284
Schistosoma mansoni	lamin	0.0032	0.0165	0.0181
Echinococcus granulosus	Nuclear pore complex protein Nup153	0.0254	0.2634	0.2964
Plasmodium vivax	T-complex protein 1 subunit beta, putative	0.0027	0.0114	0.0143
Echinococcus granulosus	cysteine protease	0.0019	0.0023	0.0022
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0109	0.1025	0.1323
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0019	0.0023	0.0074
Trypanosoma cruzi	cysteine peptidase, putative	0.0019	0.0023	0.0074
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0223	0.0284
Trypanosoma cruzi	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0254	0.2634	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0141	0.1384	0.525
Schistosoma mansoni	lamin	0.0032	0.0165	0.0181
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0022	0.0057	0.0074
Schistosoma mansoni	jumonji domain containing protein	0.006	0.0483	0.054
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0713	0.7748	1
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.0057	0.0069
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0022	0.0057	0.0204
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0254	0.2634	1
Echinococcus multilocularis	tumor protein p63	0.035	0.3708	0.3706
Leishmania major	hypothetical protein, conserved	0.0254	0.2634	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.004	0.0254	0.0328
Brugia malayi	Cathepsin L-like precursor	0.0037	0.0223	0.0288
Trypanosoma cruzi	cysteine peptidase, putative	0.0037	0.0223	0.0836
Schistosoma mansoni	hypothetical protein	0.0713	0.7748	0.8726
Onchocerca volvulus		0.0254	0.2634	0.3325
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0035	0.0195	0.0215
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0254	0.2634	1
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0114	0.1083	0.8837
Brugia malayi	glutathione reductase	0.005	0.0368	0.0475
Trypanosoma cruzi	cytochrome P450, putative	0.004	0.0254	0.0954
Plasmodium vivax	vivapain-2	0.0037	0.0223	0.0284
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0037	0.0223	0.0284
Loa Loa (eye worm)	T-complex protein 1	0.0027	0.0114	0.0148
Leishmania major	cytochrome p450-like protein	0.004	0.0254	0.0954
Onchocerca volvulus		0.0713	0.7748	1
Echinococcus multilocularis	cysteine protease	0.0037	0.0223	0.022
Echinococcus granulosus	Upstream activation factor subunit UAF30	0.0713	0.7748	0.8726
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0037	0.0223	0.0284
Schistosoma mansoni	microtubule-associated protein tau	0.0815	0.8879	1
Brugia malayi	T-complex protein 1, beta subunit	0.0027	0.0114	0.0148
Echinococcus multilocularis	cysteine protease	0.0037	0.0223	0.022
Loa Loa (eye worm)	CYP4Cod1	0.004	0.0254	0.0328
Plasmodium vivax	vivapain-2	0.0037	0.0223	0.0284
Schistosoma mansoni	zinc finger protein	0.0254	0.2634	0.2964
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0022	0.0057	0.0204
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0223	0.0284
Trypanosoma brucei	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0254	0.2634	1
Schistosoma mansoni	brg-1 associated factor	0.0713	0.7748	0.8726
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.1384	0.525
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0022	0.0057	0.0204
Loa Loa (eye worm)	fibroinase	0.0037	0.0223	0.0288
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0037	0.0223	0.0284
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0254	0.2634	0.3399
Trypanosoma brucei	trypanothione reductase	0.005	0.0368	0.1386
Onchocerca volvulus		0.0037	0.0223	0.0178
Schistosoma mansoni	hypothetical protein	0.0713	0.7748	0.8726
Brugia malayi	Cathepsin L-like precursor	0.0037	0.0223	0.0288
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0223	0.0284
Schistosoma mansoni	chaperonin containing t-complex protein 1 beta subunit tcpb	0.0027	0.0114	0.0125
Trypanosoma brucei	cytochrome P450, putative	0.004	0.0254	0.0954
Onchocerca volvulus	Cathepsin F homolog	0.0037	0.0223	0.0178
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0019	0.0023	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0087	0.0112
Leishmania major	hypothetical protein, conserved	0.0254	0.2634	1
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0713	0.7748	1
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0022	0.0057	0.044
Brugia malayi	SWIB/MDM2 domain containing protein	0.0713	0.7748	1
Plasmodium vivax	glutathione reductase, putative	0.005	0.0368	0.0471
Echinococcus granulosus	thioredoxin glutathione reductase	0.005	0.0368	0.0411
Brugia malayi	T-complex protein 1, beta subunit	0.0027	0.0114	0.0148
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0223	0.0284
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.0385	0.043
Echinococcus multilocularis	GPCR, family 2	0.0035	0.0195	0.0191
Toxoplasma gondii	thioredoxin reductase	0.005	0.0368	0.0471
Trypanosoma cruzi	hypothetical protein, conserved	0.0254	0.2634	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.0114	0.1083	0.8837
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0223	0.0284
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0195	0.0251
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.1384	0.525
Schistosoma mansoni	TRABID protein (C64 family)	0.0254	0.2634	0.2964
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0114	0.1083	0.8837
Onchocerca volvulus	Ubiquitin thioesterase ZRANB1 homolog	0.0254	0.2634	0.3325
Leishmania major	cathepsin L-like protease	0.0141	0.1384	0.525
Echinococcus granulosus	SWI:SNF matrix associated	0.0713	0.7748	0.8726
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0037	0.0223	0.0284
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0035	0.0195	0.0215
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0223	0.0284
Echinococcus multilocularis	thioredoxin glutathione reductase	0.005	0.0368	0.0365
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0035	0.0195	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0254	0.2634	0.3399
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0017	0.0004	0.0005
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0223	0.0284
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.004	0.0254	1
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0254	0.2634	1
Giardia lamblia	TCP-1 chaperonin subunit beta	0.0027	0.0114	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0037	0.0223	0.022
Trypanosoma cruzi	hypothetical protein, conserved	0.0254	0.2634	1
Onchocerca volvulus		0.0037	0.0223	0.0178
Loa Loa (eye worm)	jmjC domain-containing protein	0.006	0.0483	0.0623
Echinococcus granulosus	geminin	0.0548	0.5902	0.6646
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0223	0.0284
Brugia malayi	Papain family cysteine protease containing protein	0.0019	0.0023	0.003
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0035	0.0195	0.0251
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0037	0.0223	0.0284
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0127	0.1225	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0127	0.1225	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0223	0.0284
Plasmodium falciparum	T-complex protein 1 subunit beta	0.0027	0.0114	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0087	0.0112
Schistosoma mansoni	hypothetical protein	0.0254	0.2634	0.2964
Echinococcus granulosus	cathepsin l1	0.0037	0.0223	0.0248
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0037	0.0223	0.0284
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0381	0.0491
Chlamydia trachomatis	SWIB complex protein	0.0713	0.7748	1
Loa Loa (eye worm)	brahma associated protein	0.0713	0.7748	1
Schistosoma mansoni	ap endonuclease	0.0022	0.0057	0.0061
Echinococcus multilocularis	lamin	0.0032	0.0165	0.0161
Trypanosoma cruzi	WLM domain containing protein, putative	0.0254	0.2634	1
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0022	0.0057	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0037	0.0223	0.0248
Trypanosoma cruzi	cysteine proteinase, putative	0.0019	0.0023	0.0074
Leishmania major	cathepsin L-like protease	0.0037	0.0223	0.0836
Loa Loa (eye worm)	hypothetical protein	0.0254	0.2634	0.3399
Toxoplasma gondii	Zn-finger in Ran binding protein and others domain-containing protein	0.0254	0.2634	0.3396
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.1384	0.525
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0019	0.0023	0.0022
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0035	0.0195	0.0251
Plasmodium vivax	SWIB/MDM2 domain-containing protein, putative	0.0713	0.7748	1
Brugia malayi	Cathepsin L-like precursor	0.0037	0.0223	0.0288
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0037	0.0223	0.0284
Schistosoma mansoni	fusion	0.0254	0.2634	0.2964
Leishmania major	cathepsin L-like protease	0.0037	0.0223	0.0836
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.0057	0.0069
Schistosoma mansoni	cellular tumor antigen P53	0.0051	0.0381	0.0425
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0037	0.0223	0.0284
Entamoeba histolytica	cysteine protease, putative	0.0037	0.0223	1
Brugia malayi	Papain family cysteine protease containing protein	0.0037	0.0223	0.0288
Onchocerca volvulus		0.0254	0.2634	0.3325
Leishmania major	hypothetical protein, conserved	0.0254	0.2634	1
Leishmania major	cathepsin L-like protease	0.0037	0.0223	0.0836
Trypanosoma brucei	mitochondrial RNA binding complex 1 subunit	0.0254	0.2634	1
Trichomonas vaginalis	conserved hypothetical protein	0.0713	0.7748	1
Echinococcus multilocularis	SWI:SNF matrix associated	0.0713	0.7748	0.7747
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0114	0.1083	0.8837
Schistosoma mansoni	hypothetical protein	0.0548	0.5902	0.6646
Plasmodium falciparum	zinc finger Ran-binding domain-containing protein 2, putative	0.0254	0.2634	0.3396
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0037	0.0223	0.022
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.006	0.0483	0.054
Echinococcus granulosus	lamin	0.0032	0.0165	0.0181
Brugia malayi	Latrophilin receptor protein 2	0.0035	0.0195	0.0251
Echinococcus granulosus	intermediate filament protein	0.0032	0.0165	0.0181
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0022	0.0057	0.0054
Trichomonas vaginalis	chaperonin-60kD, ch60, putative	0.0027	0.0114	0.0143
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0087	0.0107
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0025	0.0087	0.0112
Chlamydia trachomatis	DNA topoisomerase I	0.0713	0.7748	1
Trypanosoma cruzi	trypanothione reductase, putative	0.005	0.0368	0.1386
Schistosoma mansoni	jumonji/arid domain-containing protein	0.006	0.0483	0.054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.1384	0.525
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.1384	0.525
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0165	0.0212
Loa Loa (eye worm)	cysteine protease	0.0037	0.0223	0.0288
Brugia malayi	Cathepsin L-like precursor	0.0025	0.0087	0.0112
Echinococcus multilocularis	lamin dm0	0.0032	0.0165	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0158	0.0204
Brugia malayi	Cathepsin L-like precursor	0.0037	0.0223	0.0288
Echinococcus granulosus	tumor protein p63	0.035	0.3708	0.4175
Echinococcus granulosus	lamin dm0	0.0032	0.0165	0.0181
Plasmodium falciparum	thioredoxin reductase	0.005	0.0368	0.0471
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0109	0.1025	0.1323
Onchocerca volvulus	Cathepsin L homolog	0.0037	0.0223	0.0178
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0037	0.0223	0.0284
Schistosoma mansoni	ap endonuclease	0.0022	0.0057	0.0061
Brugia malayi	brahma associated protein 60 kDa	0.0713	0.7748	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0037	0.0223	0.0284
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0127	0.1225	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0223	0.0284
Schistosoma mansoni	RNA binding protein	0.0254	0.2634	0.2964
Schistosoma mansoni	hypothetical protein	0.0035	0.0195	0.0215
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0037	0.0223	0.0288
Brugia malayi	cathepsin L-like precursor	0.0025	0.0087	0.0112
Brugia malayi	YY1-associated factor 2	0.0254	0.2634	0.3399
Plasmodium vivax	hypothetical protein, conserved	0.0713	0.7748	1
Leishmania major	cathepsin L-like protease	0.0141	0.1384	0.525
Onchocerca volvulus		0.0037	0.0223	0.0178
Schistosoma mansoni	cathepsin F (C01 family)	0.0037	0.0223	0.0248
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.1384	0.525
Brugia malayi	Cathepsin L-like precursor	0.0037	0.0223	0.0288
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.0385	0.043
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.005	0.0368	0.2985
Brugia malayi	Cytochrome P450 family protein	0.004	0.0254	0.0328
Plasmodium vivax	thioredoxin reductase, putative	0.005	0.0368	0.0471
Onchocerca volvulus		0.0037	0.0223	0.0178
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0037	0.0223	0.0248
Echinococcus granulosus	ring and YY1 binding protein	0.0254	0.2634	0.2964
Loa Loa (eye worm)	hypothetical protein	0.0254	0.2634	0.3399
Onchocerca volvulus	Cathepsin L homolog	0.0037	0.0223	0.0178
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0127	0.1225	1
Brugia malayi	Papain family cysteine protease containing protein	0.0019	0.0023	0.003
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.1384	0.525
Leishmania major	cathepsin L-like protease	0.0141	0.1384	0.525
Loa Loa (eye worm)	intermediate filament protein	0.0032	0.0165	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0127	0.0163
Echinococcus granulosus	cathepsin L cysteine protease	0.0019	0.0023	0.0022
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.1384	0.525
Trypanosoma cruzi	major cysteine proteinase, putative	0.0111	0.1048	0.3969
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0254	0.2634	1
Mycobacterium tuberculosis	Probable reductase	0.0114	0.1083	0.8837
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0223	0.0288
Leishmania major	hypothetical protein, conserved	0.0254	0.2634	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0223	0.0284
Onchocerca volvulus		0.0032	0.0165	0.0102
Loa Loa (eye worm)	ctsf protein	0.0037	0.0223	0.0288
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0052	0.0385	0.0497
Echinococcus granulosus	cathepsin L	0.0019	0.0023	0.0022
Brugia malayi	latrophilin 2 splice variant baaae	0.0075	0.0641	0.0827
Echinococcus multilocularis	geminin	0.0548	0.5902	0.5901
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0129	0.1248	0.4731
Echinococcus granulosus	zinc finger protein Ran binding	0.0254	0.2634	0.2964
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0037	0.0223	0.0284
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.0385	0.043
Loa Loa (eye worm)	glutathione reductase	0.005	0.0368	0.0475
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0037	0.0223	0.0248
Echinococcus multilocularis	chaperonin containing TCP1, subunit 2 (beta)	0.0027	0.0114	0.0111
Leishmania major	T-complex protein 1, beta subunit, putative	0.0027	0.0114	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0087	0.0112
Plasmodium vivax	vivapain-3	0.0019	0.0023	0.0025
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0037	0.0223	0.0284
Echinococcus granulosus	chaperonin containing TCP1 subunit 2 beta	0.0027	0.0114	0.0125
Brugia malayi	Cathepsin L-like precursor	0.0025	0.0087	0.0112
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0037	0.0223	0.0284
Onchocerca volvulus		0.0254	0.2634	0.3325
Entamoeba histolytica	cysteine proteinase, putative	0.0037	0.0223	1
Leishmania major	trypanothione reductase	0.005	0.0368	0.1386
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0022	0.0057	0.2143
Trypanosoma cruzi	T-complex protein 1, beta subunit, putative	0.0027	0.0114	0.0421
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0035	0.0195	0.0191
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.0385	0.043
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.0385	0.0382
Schistosoma mansoni	hypothetical protein	0.0713	0.7748	0.8726
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0023	0.0025
Echinococcus multilocularis	SWI:SNF matrix associated	0.0713	0.7748	0.7747
Loa Loa (eye worm)	thioredoxin reductase	0.005	0.0368	0.0475
Leishmania major	hypothetical protein, conserved	0.0254	0.2634	1
Onchocerca volvulus		0.0032	0.0165	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0254	0.2634	0.3399
Trichomonas vaginalis	ap endonuclease, putative	0.0022	0.0057	0.0069
Plasmodium vivax	vivapain-1	0.0019	0.0023	0.0025
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.0385	0.043
Entamoeba histolytica	cysteine proteinase, putative	0.0025	0.0087	0.3182
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0022	0.0057	0.4852
Brugia malayi	jmjC domain containing protein	0.006	0.0483	0.0623
Schistosoma mansoni	hypothetical protein	0.0035	0.0195	0.0215
Brugia malayi	Cathepsin L-like precursor	0.0037	0.0223	0.0288
Loa Loa (eye worm)	SWIB/MDM2 domain-containing protein	0.0713	0.7748	1
Schistosoma mansoni	hypothetical protein	0.0035	0.0195	0.0215
Trypanosoma cruzi	cysteine peptidase, putative	0.0141	0.1384	0.525
Toxoplasma gondii	DNA topoisomerase domain-containing protein	0.0713	0.7748	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0023	0.0025
Trypanosoma brucei	hypothetical protein, conserved	0.0254	0.2634	1
Toxoplasma gondii	t-complex protein beta subunit	0.0027	0.0114	0.0143
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0019	0.0023	0.0074
Toxoplasma gondii	SWIB/MDM2 domain-containing protein	0.0713	0.7748	1
Echinococcus multilocularis	cathepsin L	0.0019	0.0023	0.0019
Brugia malayi	jmjC domain containing protein	0.006	0.0483	0.0623
Plasmodium falciparum	glutathione reductase	0.005	0.0368	0.0471
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0032	0.0165	0.0212
Plasmodium vivax	unspecified product	0.0019	0.0023	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0254	0.2634	0.3399
Schistosoma mansoni	chaperonin containing t-complex protein 1 beta subunit tcpb	0.0027	0.0114	0.0125
Trypanosoma cruzi	cysteine peptidase, putative	0.0141	0.1384	0.525
Echinococcus multilocularis	ring and YY1 binding protein	0.0254	0.2634	0.2631
Trypanosoma cruzi	cysteine peptidase, putative	0.0141	0.1384	0.525
Leishmania major	cathepsin L-like protease	0.0037	0.0223	0.0836
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.0385	0.0382
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0019	0.0023	0.0074
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0019	0.0023	0.0025
Echinococcus multilocularis	cathepsin L cysteine protease	0.0037	0.0223	0.022
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0022	0.0057	0.1711
Echinococcus multilocularis	zinc finger protein Ran binding	0.0254	0.2634	0.2631
Schistosoma mansoni	cathepsin F (C01 family)	0.0025	0.0087	0.0094
Trypanosoma brucei	hypothetical protein, conserved	0.0254	0.2634	1
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0254	0.2634	0.3399
Schistosoma mansoni	jumonji/arid domain-containing protein	0.006	0.0483	0.054
Onchocerca volvulus		0.0254	0.2634	0.3325
Brugia malayi	Intermediate filament tail domain containing protein	0.0032	0.0165	0.0212
Toxoplasma gondii	exonuclease III APE	0.0022	0.0057	0.0069
Schistosoma mansoni	hypothetical protein	0.0075	0.0641	0.0718
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0052	0.0385	0.0497
Schistosoma mansoni	hypothetical protein	0.0548	0.5902	0.6646
Onchocerca volvulus		0.0037	0.0223	0.0178
Trypanosoma cruzi	WLM domain containing protein, putative	0.0254	0.2634	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0022	0.0057	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 22 uM	Inhibition of farnesyl transferase	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 271350

Bibliographic References

No literature references available for this target.

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Detailed information for compound 171719