Detailed information for compound 1718917

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 479.629 | Formula: C29H38FN3O2
  • H donors: 2 H acceptors: 2 LogP: 6.01 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cccc(c1)N(C(c1ccccc1C)C(=O)NC1CCCCC1)C(=O)CNC1CCCCC1
  • InChi: 1S/C29H38FN3O2/c1-21-11-8-9-18-26(21)28(29(35)32-24-15-6-3-7-16-24)33(25-17-10-12-22(30)19-25)27(34)20-31-23-13-4-2-5-14-23/h8-12,17-19,23-24,28,31H,2-7,13-16,20H2,1H3,(H,32,35)
  • InChiKey: QSEWQPHOUBNHBH-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.004 0.0039
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0012 0.0013
Loa Loa (eye worm) hypothetical protein 0.0033 0.0105 0.0115
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0038 0.0131 0.095
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0038 0.0131 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0177 0.1285
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0012 0.0045
Loa Loa (eye worm) vab-3 0.0033 0.0105 0.0115
Echinococcus granulosus paired box protein pax 6 0.0033 0.0105 0.0433
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0012
Onchocerca volvulus 0.0033 0.0105 0.0115
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0159 0.0771 0.5599
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.012 0.0119
Schistosoma mansoni survival motor neuron protein 0.0096 0.0437 0.3173
Echinococcus multilocularis Aminotransferase class III 0.0271 0.1362 0.1624
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0038 0.0131 0.0538
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.0789 0.0941
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.012 0.0873
Trypanosoma cruzi Aminopeptidase M1, putative 0.0038 0.0131 1
Entamoeba histolytica hypothetical protein 0.0036 0.012 0.7628
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.0178 0.0177
Loa Loa (eye worm) glutaminase 0.0274 0.1377 0.1518
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0001 0.0001
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0025 0.006 0.0438
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0271 0.1362 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0106 0.0116
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0271 0.1362 0.5
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.056 0.0617
Leishmania major hypothetical protein, conserved 0.0035 0.0115 0.8807
Schistosoma mansoni paired box protein pax-6 0.0033 0.0105 0.0766
Echinococcus multilocularis GPCR, family 2 0.0015 0.0012 0.0013
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0162 0.0789 0.087
Toxoplasma gondii histone lysine methyltransferase SET1 0.0178 0.087 0.6384
Echinococcus granulosus mixed lineage leukemia protein mll 0.0023 0.0051 0.0207
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0038 0.0131 0.013
Trichomonas vaginalis helicase, putative 0.0021 0.004 0.0039
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0187 0.0206
Brugia malayi CXXC zinc finger family protein 0.0092 0.0415 0.0457
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0038 0.0131 0.095
Loa Loa (eye worm) aminopeptidase N 0.0038 0.0131 0.0143
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0177 0.073
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0121 0.012
Loa Loa (eye worm) beta-lactamase 0.0036 0.012 0.0132
Schistosoma mansoni hypothetical protein 0.0015 0.0012 0.0085
Schistosoma mansoni hypothetical protein 0.0096 0.0437 0.3173
Loa Loa (eye worm) RNA binding protein 0.0131 0.0624 0.0688
Echinococcus multilocularis aminopeptidase N 0.0038 0.0131 0.0155
Loa Loa (eye worm) glutaminase 2 0.0274 0.1377 0.1518
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0038 0.0131 1
Entamoeba histolytica hypothetical protein 0.0036 0.012 0.7628
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.004 0.0039
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0271 0.1362 0.1257
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0035 0.0115 0.8807
Schistosoma mansoni alpha-glucosidase 0.014 0.067 0.4864
Echinococcus granulosus paired box gene 3/7 (eyeless, eyegone, twin of eyeless) 0.0033 0.0105 0.0433
Trichomonas vaginalis esterase, putative 0.0036 0.012 0.0119
Echinococcus granulosus aminopeptidase N 0.0038 0.0131 0.0538
Loa Loa (eye worm) acetyltransferase 0.0159 0.0771 0.085
Toxoplasma gondii ABC1 family protein 0.0036 0.012 0.0877
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0038 0.0131 0.0155
Schistosoma mansoni hypothetical protein 0.0015 0.0012 0.0085
Loa Loa (eye worm) hypothetical protein 0.0036 0.012 0.0132
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0038 0.0131 0.0155
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0001 0.0042
Brugia malayi follicle stimulating hormone receptor 0.0236 0.1179 0.1299
Mycobacterium ulcerans hypothetical protein 0.0036 0.012 0.0119
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.004 0.0039
Mycobacterium ulcerans beta-lactamase 0.0036 0.012 0.0119
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.012 0.0119
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.056 0.0617
Echinococcus multilocularis paired box protein pax 6 0.0033 0.0105 0.0125
Loa Loa (eye worm) hypothetical protein 0.0025 0.006 0.0066
Brugia malayi beta-lactamase family protein 0.0036 0.012 0.0132
Echinococcus multilocularis ornithine aminotransferase 0.0271 0.1362 0.1624
Brugia malayi hypothetical protein 0.0036 0.012 0.0132
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0177 0.0194
Toxoplasma gondii Erv1 / Alr family protein 0.0035 0.0115 0.0841
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0121 0.0133
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0121 0.012
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0001 0.0001
Brugia malayi Peptidase family M1 containing protein 0.0038 0.0131 0.0143
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.004 0.0039
Echinococcus multilocularis paired box protein pax 1 0.0033 0.0105 0.0125
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0038 0.0131 0.0155
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0121 0.012
Onchocerca volvulus 0.0038 0.0131 0.0143
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.012 0.0119
Trypanosoma brucei Aminopeptidase M1, putative 0.0038 0.0131 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0001 0.0001
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0038 0.0131 1
Loa Loa (eye worm) hypothetical protein 0.047 0.2414 0.2662
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.004 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.004 0.0039
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0121 0.012
Brugia malayi paired box protein 0.0033 0.0105 0.0115
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0001 0.0001
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0012 0.0012
Echinococcus multilocularis paired box protein pax 6 0.0033 0.0105 0.0125
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0121 0.0143
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0035 0.0115 0.8807
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.012 0.0119
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.0178 0.0733
Echinococcus multilocularis paired box protein pax 6 0.0033 0.0105 0.0125
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0195 0.0959 0.6965
Brugia malayi Augmenter of liver regeneration 0.0035 0.0115 0.0126
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.004 0.0039
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0121 0.7687
Schistosoma mansoni hypothetical protein 0.0015 0.0012 0.0085
Brugia malayi paired box pox-meso protein 0.0033 0.0105 0.0115
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0271 0.1362 0.1257
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.0001 0.0001
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.1904 1 1
Echinococcus multilocularis tar DNA binding protein 0.0131 0.0624 0.0744
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0023 0.0051 0.006
Echinococcus multilocularis cpg binding protein 0.0097 0.0443 0.0527
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0001 0.0001
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0025 0.006 0.0071
Schistosoma mansoni cpg binding protein 0.0097 0.0443 0.3217
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0177 0.021
Entamoeba histolytica hypothetical protein 0.0036 0.012 0.7628
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0121 0.9248
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.012 0.0142
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0012 0.0012
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.012 0.0119
Schistosoma mansoni alpha glucosidase 0.0036 0.0121 0.0879
Mycobacterium ulcerans aminopeptidase N PepN 0.0038 0.0131 0.013
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0271 0.1362 0.1257
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0271 0.1362 0.989
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0035 0.0115 0.8807
Brugia malayi TAR-binding protein 0.0131 0.0624 0.0688
Loa Loa (eye worm) hypothetical protein 0.0033 0.0106 0.0116
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.0789 0.0941
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0177 0.1285
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.1904 1 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.012 0.0132
Mycobacterium tuberculosis Probable aminotransferase 0.1904 1 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0028 0.008 0.0095
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0035 0.0115 0.8807
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0121 0.012
Brugia malayi RNA binding protein 0.0131 0.0624 0.0688
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0271 0.1362 0.1257
Loa Loa (eye worm) hypothetical protein 0.0025 0.006 0.0066
Loa Loa (eye worm) hypothetical protein 0.0025 0.006 0.0066
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0177 0.021
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0028 0.008 0.033
Echinococcus granulosus ornithine aminotransferase 0.0271 0.1362 0.5641
Loa Loa (eye worm) hypothetical protein 0.0036 0.012 0.0132
Trypanosoma brucei glucosidase, putative 0.0036 0.0121 0.9248
Toxoplasma gondii Erv1 / Alr family protein 0.0035 0.0115 0.0841
Onchocerca volvulus 0.0036 0.012 0.0132
Entamoeba histolytica aminopeptidase, putative 0.0038 0.0131 0.8315
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0121 0.0133
Trypanosoma brucei glycosyl hydrolase-like protein 0.0013 0.0001 0.0042
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.004 0.0039
Onchocerca volvulus 0.0038 0.0131 0.0143
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0187 0.0206
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.0178 0.1299
Echinococcus granulosus GPCR family 2 0.0015 0.0012 0.0045
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.0157 0.1147
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0121 0.012
Loa Loa (eye worm) hypothetical protein 0.0036 0.012 0.0132
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0035 0.0115 0.0474
Brugia malayi beta-lactamase 0.0036 0.012 0.0132
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0038 0.0131 0.013
Echinococcus multilocularis survival motor neuron protein 1 0.047 0.2414 0.2878
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.012 0.0872
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0001 0.0001
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0187 0.0206
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0121 0.9248
Schistosoma mansoni hypothetical protein 0.0015 0.0012 0.0085
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.012 0.0494
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.0157 1
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0035 0.0115 0.0841
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0624 0.4533
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0121 0.012
Brugia malayi hypothetical protein 0.0038 0.0131 0.0143
Brugia malayi glutaminase DH11.1 0.0274 0.1377 0.1518
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0013 0.0001 0.0006
Brugia malayi F/Y-rich N-terminus family protein 0.0028 0.0079 0.0086
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0035 0.0115 0.0841
Loa Loa (eye worm) hypothetical protein 0.0033 0.0105 0.0115
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0038 0.0131 0.0155
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0177 0.073
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0624 0.4533
Mycobacterium ulcerans acetylornithine aminotransferase 0.0271 0.1362 0.1361
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.0051 0.037
Mycobacterium ulcerans L-lysine aminotransferase 0.0271 0.1362 0.1361
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0012 0.0013
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.012 0.9188
Trichomonas vaginalis glutaminase, putative 0.0274 0.1377 0.1376
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0121 0.0498
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0012 0.0045
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0177 0.1285
Loa Loa (eye worm) hypothetical protein 0.0033 0.0105 0.0115
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0271 0.1362 0.1257
Echinococcus granulosus histone acetyltransferase KAT2B 0.0155 0.0747 0.3094
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0121 0.9248
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.012 0.0495
Onchocerca volvulus 0.0036 0.012 0.0132
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.012 0.0142
Schistosoma mansoni hypothetical protein 0.0033 0.0106 0.077
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0121 0.7687
Brugia malayi 'Paired box' domain containing protein 0.0033 0.0105 0.0115
Loa Loa (eye worm) TAR-binding protein 0.0131 0.0624 0.0688
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0001 0.0001
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.004 0.0039
Plasmodium vivax ornithine aminotransferase, putative 0.0271 0.1362 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0096 0.0437 0.0481
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0121 0.012
Schistosoma mansoni paired box protein pax-1-related 0.0033 0.0105 0.0766
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0001 0.0042
Brugia malayi 'Paired box' domain containing protein 0.0033 0.0105 0.0115
Echinococcus granulosus paired box protein pax 6 0.0033 0.0105 0.0433
Trypanosoma brucei Aminopeptidase M1, putative 0.0038 0.0131 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0038 0.0131 0.0538
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0624 0.4533
Echinococcus granulosus Aminotransferase class III 0.0271 0.1362 0.5641
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.004 0.0039
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0271 0.1362 0.1361
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0038 0.0131 0.0538
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.012 0.0132
Schistosoma mansoni paired box protein pax-6 0.0033 0.0105 0.0766
Brugia malayi RNA recognition motif domain containing protein 0.0131 0.0624 0.0688
Onchocerca volvulus 0.0092 0.0415 0.0457
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0038 0.0131 0.0155
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.004 0.0039
Echinococcus granulosus survival motor neuron protein 1 0.047 0.2414 1
Mycobacterium ulcerans glutaminase 0.0274 0.1377 0.1376
Brugia malayi acetyltransferase, GNAT family protein 0.0159 0.0771 0.085
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.004 0.0039
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0035 0.0115 0.0136
Loa Loa (eye worm) pax transcription factor protein 2 0.1728 0.9066 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.004 0.0039
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0177 0.0194
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0271 0.1362 0.1257
Entamoeba histolytica hypothetical protein 0.0036 0.012 0.7628
Brugia malayi 'Paired box' domain containing protein 0.0033 0.0105 0.0115
Schistosoma mansoni cpg binding protein 0.0097 0.0443 0.3217
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.004 0.0039
Onchocerca volvulus 0.0036 0.012 0.0132
Echinococcus granulosus lysosomal alpha glucosidase 0.0162 0.0789 0.3268
Schistosoma mansoni alpha-glucosidase 0.014 0.067 0.4864
Loa Loa (eye worm) hypothetical protein 0.0036 0.012 0.0132
Leishmania major hypothetical protein, conserved 0.0036 0.012 0.9188
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.0178 0.1299
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0271 0.1362 0.1502
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1599 0.8385 1
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0271 0.1362 0.1361
Onchocerca volvulus 0.0033 0.0105 0.0115
Leishmania major glycosyl hydrolase-like protein 0.0013 0.0001 0.0042
Brugia malayi Peptidase family M1 containing protein 0.0038 0.0131 0.0143
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.012 0.9188
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0025 0.006 0.4578
Onchocerca volvulus Retinal homeobox protein Rx homolog 0.0033 0.0105 0.0115
Plasmodium vivax hypothetical protein, conserved 0.0036 0.012 0.0877
Brugia malayi Pax transcription factor protein 2 0.1728 0.9066 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0131 0.0624 0.0688
Loa Loa (eye worm) hypothetical protein 0.0036 0.012 0.0132
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.012 0.0873
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.1143 0.1035
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0624 0.4533
Brugia malayi Glycosyl hydrolases family 31 protein 0.0162 0.0789 0.087
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0038 0.0131 1
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.012 0.9188
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0038 0.0131 0.0538
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0271 0.1362 0.1257
Loa Loa (eye worm) histone methyltransferase 0.0028 0.008 0.0088
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0023 0.0051 0.0207
Loa Loa (eye worm) hypothetical protein 0.0033 0.0105 0.0115
Onchocerca volvulus 0.0094 0.0427 0.047
Schistosoma mansoni hypothetical protein 0.0036 0.012 0.0872
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.004 0.0039
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0271 0.1362 0.1361
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0236 0.1179 0.1299
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0036 0.012 0.0132
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0121 0.012
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.0178 0.1299
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0023 0.0051 0.006
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0001 0.0001
Brugia malayi MH2 domain containing protein 0.0119 0.056 0.0617
Echinococcus granulosus tar DNA binding protein 0.0131 0.0624 0.2583
Schistosoma mansoni cpg binding protein 0.0092 0.0415 0.3016
Loa Loa (eye worm) hypothetical protein 0.0049 0.0187 0.0206
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.1904 1 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0038 0.0131 0.0155
Schistosoma mansoni aminopeptidase A (M01 family) 0.0013 0.0001 0.0006
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0624 0.4533
Onchocerca volvulus 0.1728 0.9066 1
Echinococcus granulosus paired box protein pax 1 0.0033 0.0105 0.0433
Brugia malayi vab-3 gene. 0.0033 0.0105 0.0115
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.0178 0.0177
Mycobacterium ulcerans lipase LipD 0.0036 0.012 0.0119
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.0157 0.5
Trypanosoma cruzi aminopeptidase, putative 0.0038 0.0131 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0001
Brugia malayi beta-lactamase family protein 0.0036 0.012 0.0132
Schistosoma mansoni glutaminase 0.0274 0.1377 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0092 0.0415 0.0457
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0012 0.0012
Plasmodium falciparum ornithine aminotransferase 0.0271 0.1362 1
Loa Loa (eye worm) paired box protein 0.0033 0.0105 0.0115
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0013 0.0001 0.0006
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0159 0.0771 0.0919
Brugia malayi hypothetical protein 0.047 0.2414 0.2662
Echinococcus granulosus cpg binding protein 0.0097 0.0443 0.1833
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0001 0.0001
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0271 0.1362 0.1361
Schistosoma mansoni paired box protein pax-6 0.0033 0.0105 0.0766
Echinococcus multilocularis ornithine aminotransferase 0.0271 0.1362 0.1624
Onchocerca volvulus 0.0096 0.0437 0.0481
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.012 0.0119
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0271 0.1362 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0121 0.0883
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.012 0.0119
Mycobacterium ulcerans hypothetical protein 0.1904 1 1
Loa Loa (eye worm) hepatopoietin HPO2 0.0035 0.0115 0.0126
Brugia malayi Gooseberry protein 0.0033 0.0105 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.004 0.0039

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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