Detailed information for compound 1726201

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 386.529 | Formula: C26H30N2O
  • H donors: 1 H acceptors: 1 LogP: 4.82 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(Cc1ccc(cc1)CNC(=O)Cc1ccc(cc1)c1ccccc1)CC
  • InChi: 1S/C26H30N2O/c1-3-28(4-2)20-23-12-10-22(11-13-23)19-27-26(29)18-21-14-16-25(17-15-21)24-8-6-5-7-9-24/h5-17H,3-4,18-20H2,1-2H3,(H,27,29)
  • InChiKey: ABMCRHVRUHLJOQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0179 0.0179
Echinococcus multilocularis g protein coupled receptor 0.0068 0.1193 0.1193
Echinococcus granulosus para nitrobenzyl esterase 0.0035 0.0502 0.0502
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0203 0.052
Schistosoma mansoni cpg binding protein 0.0037 0.0543 0.0543
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0414 0.3005
Brugia malayi G-protein coupled receptor 0.0068 0.1193 0.132
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0203 0.0203
Echinococcus multilocularis g-protein coupled receptor 0.0068 0.1193 0.1193
Echinococcus granulosus somatostatin receptor 0.0068 0.1193 0.1193
Loa Loa (eye worm) hypothetical protein 0.0182 0.3558 0.3933
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1378 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0068 0.1193 0.1193
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0179 0.0179
Brugia malayi Cathepsin L-like precursor 0.002 0.0203 0.0224
Trypanosoma brucei mercaptopyruvate sulfurtransferase, putative 0.0016 0.0106 0.0769
Echinococcus granulosus biogenic amine 5HT receptor 0.0068 0.1193 0.1193
Brugia malayi Lipocalin / cytosolic fatty-acid binding protein family protein 0.0375 0.7549 0.8352
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0203 0.0217
Onchocerca volvulus 0.0016 0.0106 0.0108
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0179 0.0179
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0179 0.0191
Brugia malayi hypothetical protein 0.002 0.0191 0.0211
Brugia malayi Muscleblind-like protein 0.0447 0.9039 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0254 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Brugia malayi follicle stimulating hormone receptor 0.0068 0.1193 0.132
Mycobacterium leprae Conserved hypothetical protein 0.0016 0.0106 0.5
Loa Loa (eye worm) carboxylesterase 0.0035 0.0502 0.0549
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0254 0.3745
Schistosoma mansoni BC026374 protein (S09 family) 0.0035 0.0502 0.0502
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0068 0.1193 0.1193
Brugia malayi cathepsin L-like precursor 0.0014 0.0065 0.0071
Schistosoma mansoni hypothetical protein 0.0068 0.1193 0.1193
Mycobacterium leprae PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN MOEB1 (MPT-SYNTHASE SULFURYLASE) (MOLYBDOPTERIN SYNTHASE SULPHURYLASE) 0.0016 0.0106 0.5
Echinococcus granulosus fmrfamide receptor 0.0068 0.1193 0.1193
Echinococcus multilocularis G protein coupled receptor 139 0.0068 0.1193 0.1193
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0068 0.1193 0.1193
Schistosoma mansoni biogenic amine (5HT) receptor 0.0068 0.1193 0.1193
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.0065 0.0165
Brugia malayi AKH receptor 0.0068 0.1193 0.132
Echinococcus granulosus hypothetical protein 0.0068 0.1193 0.1193
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0179 0.0179
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0068 0.1193 0.1193
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0068 0.1193 0.1193
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.1193 0.1193
Onchocerca volvulus 0.0068 0.1193 0.2943
Schistosoma mansoni hypothetical protein 0.0016 0.0106 0.0106
Onchocerca volvulus 0.0068 0.1193 0.2943
Brugia malayi Tachykinin-like peptides receptor 99D 0.0068 0.1193 0.132
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.1193 0.1193
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0254 0.614
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0068 0.1193 0.1193
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0068 0.1193 0.132
Echinococcus granulosus 7tm_1 domain containing protein 0.0068 0.1193 0.1193
Brugia malayi Dopamine receptor protein 2 0.0068 0.1193 0.132
Echinococcus granulosus g protein coupled receptor 0.0068 0.1193 0.1193
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0068 0.1193 0.1193
Loa Loa (eye worm) hypothetical protein 0.0035 0.0502 0.0549
Onchocerca volvulus 0.0068 0.1193 0.2943
Entamoeba histolytica rodhanase-like domain containing protein 0.0199 0.3899 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Brugia malayi Carboxylesterase family protein 0.0205 0.4031 0.4459
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1378 1
Schistosoma mansoni opsin-like receptor 0.0068 0.1193 0.1193
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.1037 0.7525
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1378 1
Schistosoma mansoni biogenic amine receptor 0.0068 0.1193 0.1193
Echinococcus multilocularis fatty acid binding protein FABP2 0.0375 0.7549 0.7549
Echinococcus granulosus tar DNA binding protein 0.0064 0.1103 0.1103
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0414 0.3005
Leishmania major cathepsin L-like protease 0.002 0.0203 0.0761
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0068 0.1193 0.1314
Echinococcus multilocularis G-protein coupled receptor, putative 0.0068 0.1193 0.1193
Loa Loa (eye worm) hypothetical protein 0.0035 0.0502 0.0549
Loa Loa (eye worm) neuropeptide F receptor 0.0068 0.1193 0.1314
Schistosoma mansoni biogenic amine (5HT) receptor 0.0068 0.1193 0.1193
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0203 0.0203
Onchocerca volvulus 0.0068 0.1193 0.2943
Echinococcus granulosus neuropeptide FF receptor 2 0.0068 0.1193 0.1193
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0068 0.1193 0.1193
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0016 0.0106 0.0769
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0064
Onchocerca volvulus 0.002 0.0203 0.0361
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0254 0.5
Echinococcus multilocularis heat shock protein 67b2 0.0016 0.0106 0.0106
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0068 0.1193 0.1193
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.0016 0.0106 0.0106
Echinococcus multilocularis acetylcholinesterase 0.0205 0.4031 0.4031
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0199 0.3899 1
Brugia malayi Carboxylesterase family protein 0.0035 0.0502 0.0555
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0179 0.13
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0068 0.1193 0.1193
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0016 0.0106 0.0769
Echinococcus granulosus cathepsin l1 0.0014 0.0065 0.0065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0203 0.052
Schistosoma mansoni gliotactin 0.0035 0.0502 0.0502
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1378 1
Loa Loa (eye worm) hypothetical protein 0.0205 0.4031 0.4455
Brugia malayi hypothetical protein 0.0068 0.1193 0.132
Brugia malayi Cathepsin L-like precursor 0.0014 0.0065 0.0071
Brugia malayi G-protein coupled receptor 0.0068 0.1193 0.132
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0203 0.0203
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0203 0.052
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0179 0.0706
Schistosoma mansoni hypothetical protein 0.0205 0.4017 0.4017
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0254 0.1845
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0179 0.0179
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1193 0.1193
Plasmodium vivax mitogen-activated protein kinase phosphatase 1, putative 0.0016 0.0106 0.2558
Trypanosoma cruzi As/Sb Reductase, putative 0.0016 0.0106 0.0769
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0732 0.0809
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1103 0.1103
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.1378 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0203 0.0224
Brugia malayi ORL1-like opioid receptor 0.0068 0.1193 0.132
Loa Loa (eye worm) acetylcholinesterase 1 0.0205 0.4031 0.4455
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.1193 0.1193
Loa Loa (eye worm) hypothetical protein 0.0016 0.0106 0.011
Loa Loa (eye worm) carboxylesterase 0.0205 0.4031 0.4455
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0068 0.1193 0.1193
Loa Loa (eye worm) hypothetical protein 0.0035 0.0502 0.0549
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1378 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0732 0.0732
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0203 0.052
Schistosoma mansoni histamine h1 receptor 0.0068 0.1193 0.1193
Schistosoma mansoni growth hormone secretagogue receptor 0.0068 0.1193 0.1193
Brugia malayi hypothetical protein 0.0182 0.3558 0.3937
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0732 0.0732
Brugia malayi neuropeptide F receptor 0.0068 0.1193 0.132
Echinococcus granulosus g-protein coupled receptor 0.0068 0.1193 0.1193
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0106 0.0272
Schistosoma mansoni ap endonuclease 0.0023 0.0254 0.0254
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0065 0.0165
Entamoeba histolytica rodhanase-like domain containing protein 0.0199 0.3899 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0254 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0203 0.052
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0414 0.3005
Loa Loa (eye worm) hypothetical protein 0.0447 0.9039 1
Trypanosoma brucei rhodanese-like domain containing protein, putative 0.0016 0.0106 0.0769
Onchocerca volvulus 0.002 0.0203 0.0361
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Echinococcus multilocularis muscleblind protein 0.0447 0.9039 0.9039
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0203 0.052
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0068 0.1193 0.1193
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1378 1
Onchocerca volvulus 0.0035 0.0502 0.1141
Loa Loa (eye worm) hypothetical protein 0.0016 0.0106 0.011
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0179 0.0179
Loa Loa (eye worm) hypothetical protein 0.0016 0.0106 0.011
Echinococcus multilocularis para nitrobenzyl esterase 0.0035 0.0502 0.0502
Echinococcus granulosus neuroligin 0.0035 0.0502 0.0502
Brugia malayi Cathepsin L-like cysteine proteinase 0.0014 0.0065 0.0071
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0254 0.3745
Brugia malayi Rhodanese-like domain containing protein 0.0199 0.3899 0.4314
Echinococcus granulosus centrosomal protein of 41 kDa 0.0016 0.0106 0.0106
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0199 0.3899 1
Schistosoma mansoni neuropeptide receptor 0.0068 0.1193 0.1193
Plasmodium vivax vivapain-2 0.002 0.0203 0.4896
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0064
Loa Loa (eye worm) G-protein coupled receptor 0.0068 0.1193 0.1314
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0203 0.0203
Echinococcus granulosus orexin receptor type 2 0.0068 0.1193 0.1193
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0068 0.1193 0.1193
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Schistosoma mansoni neuropeptide receptor 0.0068 0.1193 0.1193
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1193 0.1193
Loa Loa (eye worm) hypothetical protein 0.0035 0.0502 0.0549
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0732 0.0803
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1103 0.1103
Plasmodium vivax rhodanese like protein, putative 0.0016 0.0106 0.2558
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0035 0.0502 0.0502
Loa Loa (eye worm) hypothetical protein 0.0035 0.0502 0.0549
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0179 0.0706
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0179 0.0198
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Brugia malayi hypothetical protein 0.0068 0.1193 0.132
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0016 0.0106 0.0272
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0179 0.13
Plasmodium falciparum rhodanese like protein, putative 0.0016 0.0106 0.2558
Entamoeba histolytica rodhanase-like domain containing protein 0.0016 0.0106 0.0272
Echinococcus granulosus cathepsin l1 0.002 0.0203 0.0203
Echinococcus granulosus Rhodanese 0.0016 0.0106 0.0106
Loa Loa (eye worm) RNA binding protein 0.0064 0.1103 0.1214
Brugia malayi Carboxylesterase family protein 0.0035 0.0502 0.0555
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1193 0.1193
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0016 0.0106 0.0769
Brugia malayi Melatonin receptor type 1A 0.0068 0.1193 0.132
Echinococcus granulosus heat shock protein 67b2 0.0016 0.0106 0.0106
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.1193 0.1193
Echinococcus granulosus neuropeptide s receptor 0.0068 0.1193 0.1193
Loa Loa (eye worm) hypothetical protein 0.0199 0.3899 0.4309
Schistosoma mansoni amine GPCR 0.0068 0.1193 0.1193
Toxoplasma gondii cathepsin CPL 0.002 0.0203 0.0933
Echinococcus multilocularis cysteine protease 0.002 0.0203 0.0203
Echinococcus granulosus geminin 0.0205 0.4017 0.4017
Brugia malayi hypothetical protein 0.0068 0.1193 0.132
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0203 0.052
Echinococcus granulosus acetylcholinesterase 0.0205 0.4031 0.4031
Echinococcus granulosus serotonin receptor 0.0068 0.1193 0.1193
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0732 0.0732
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Onchocerca volvulus 0.0068 0.1193 0.2943
Echinococcus multilocularis fmrfamide receptor 0.0068 0.1193 0.1193
Schistosoma mansoni fatty acid binding protein 0.0375 0.7549 0.7549
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0414 1
Brugia malayi isocitrate dehydrogenase 0.0019 0.0179 0.0198
Brugia malayi neuropeptide F receptor 0.0068 0.1193 0.132
Leishmania major hypothetical protein, conserved 0.003 0.0414 0.2423
Loa Loa (eye worm) hypothetical protein 0.0035 0.0502 0.0549
Echinococcus granulosus m phase inducer phosphatasecdc25 0.0199 0.3899 0.3899
Loa Loa (eye worm) hypothetical protein 0.0447 0.9039 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0065 0.0165
Leishmania major cathepsin L-like protease 0.0077 0.1378 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0254 0.0274
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0203 0.052
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0068 0.1193 0.132
Brugia malayi sulfakinin receptor protein 0.0068 0.1193 0.132
Echinococcus multilocularis m phase inducer phosphatase(cdc25) 0.0199 0.3899 0.3899
Echinococcus granulosus tachykinin peptides receptor 99D 0.0068 0.1193 0.1193
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0035 0.0502 0.0502
Echinococcus granulosus G protein coupled receptor 139 0.0068 0.1193 0.1193
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0068 0.1193 0.1193
Echinococcus granulosus 7TM GPCR rhodopsin 0.0068 0.1193 0.1193
Trypanosoma brucei rhodanese-like domain containing protein, putative 0.0016 0.0106 0.0769
Echinococcus multilocularis fmrfamide receptor 0.0068 0.1193 0.1193
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0199 0.3899 1
Schistosoma mansoni opsin-like receptor 0.0068 0.1193 0.1193
Schistosoma mansoni amine GPCR 0.0068 0.1193 0.1193
Onchocerca volvulus 0.0068 0.1193 0.2943
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0203 0.052
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.124 0.8997
Echinococcus multilocularis tRNA 2 selenouridine synthase 0.0016 0.0106 0.0106
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.1193 0.1193
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0203 0.0203
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Echinococcus granulosus carboxylesterase 5A 0.0205 0.4031 0.4031
Echinococcus granulosus fatty acid binding protein FABP2 0.0375 0.7549 0.7549
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0068 0.1193 0.1193
Schistosoma mansoni hypothetical protein 0.0068 0.1193 0.1193
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1378 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0068 0.1193 0.1193
Trichomonas vaginalis cdc25c, putative 0.0199 0.3899 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1378 1
Schistosoma mansoni hypothetical protein 0.0068 0.1193 0.1193
Onchocerca volvulus 0.0068 0.1193 0.2943
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0179 0.13
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0068 0.1193 0.1193
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0068 0.1193 0.1314
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0732 0.0732
Onchocerca volvulus 0.002 0.0203 0.0361
Brugia malayi Carboxylesterase family protein 0.0205 0.4031 0.4459
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0067 0.0067
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0068 0.1193 0.1193
Brugia malayi Cathepsin L-like precursor 0.002 0.0203 0.0224
Echinococcus granulosus fatty acid binding protein FABP2 0.0375 0.7549 0.7549
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Schistosoma mansoni biogenic amine receptor 0.0068 0.1193 0.1193
Trypanosoma brucei rhodanese-like domain containing protein, putative 0.0016 0.0106 0.0769
Brugia malayi RE15519p 0.0068 0.1193 0.132
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0203 0.052
Onchocerca volvulus 0.0068 0.1193 0.2943
Onchocerca volvulus 0.002 0.0203 0.0361
Echinococcus granulosus neuropeptide receptor A26 0.0068 0.1193 0.1193
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0068 0.1193 0.1314
Entamoeba histolytica rodhanase-like domain containing protein 0.0016 0.0106 0.0272
Echinococcus granulosus neuropeptide receptor 0.0068 0.1193 0.1193
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0502 0.0548
Echinococcus multilocularis serotonin receptor 0.0068 0.1193 0.1193
Mycobacterium ulcerans carboxylesterase, LipT 0.0035 0.0502 1
Schistosoma mansoni opsin-like receptor 0.0068 0.1193 0.1193
Brugia malayi Serotonin receptor 0.0068 0.1193 0.132
Echinococcus granulosus neuropeptide receptor 0.0068 0.1193 0.1193
Brugia malayi hypothetical protein 0.0068 0.1193 0.132
Trichomonas vaginalis Phage shock protein E precursor, putative 0.0016 0.0106 0.0272
Echinococcus multilocularis carboxylesterase 5A 0.0205 0.4031 0.4031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0203 0.052
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.0199 0.3899 0.3899
Schistosoma mansoni cpg binding protein 0.0037 0.0543 0.0543
Entamoeba histolytica hypothetical protein 0.0016 0.0106 0.0272
Entamoeba histolytica hypothetical protein, conserved 0.0016 0.0106 0.0272
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0035 0.0502 1
Echinococcus granulosus muscleblind protein 0.0447 0.9039 0.9039
Schistosoma mansoni hypothetical protein 0.0016 0.0106 0.0106
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1378 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0203 0.052
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0414 0.297
Onchocerca volvulus 0.0068 0.1193 0.2943
Echinococcus multilocularis Rhodanese 0.0016 0.0106 0.0106
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.1193 0.1193
Brugia malayi RIKEN cDNA 4930451A13 0.0016 0.0106 0.0117
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1193 0.1193
Onchocerca volvulus 0.002 0.0203 0.0361
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0106 0.0769
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.1193 0.1193
Loa Loa (eye worm) hypothetical protein 0.0205 0.4031 0.4455
Onchocerca volvulus 0.0068 0.1193 0.2943
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Loa Loa (eye worm) hypothetical protein 0.003 0.0414 0.0451
Echinococcus granulosus g protein coupled receptor 0.0068 0.1193 0.1193
Toxoplasma gondii exonuclease III APE 0.0023 0.0254 0.143
Schistosoma mansoni amine GPCR 0.0068 0.1193 0.1193
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0064
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0254 0.614
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Onchocerca volvulus 0.0035 0.0502 0.1141
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.0065 0.0065
Echinococcus granulosus BC026374 protein S09 family 0.0035 0.0502 0.0502
Schistosoma mansoni adenoreceptor 0.0068 0.1193 0.1193
Onchocerca volvulus 0.0035 0.0502 0.1141
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0732 0.0732
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0106 0.0272
Brugia malayi G protein-coupled receptor 0.0068 0.1193 0.132
Schistosoma mansoni amine GPCR 0.0068 0.1193 0.1193
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0254 0.1845
Loa Loa (eye worm) TYRA-2 protein 0.0068 0.1193 0.1314
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Echinococcus multilocularis neuropeptide receptor 0.0068 0.1193 0.1193
Loa Loa (eye worm) hypothetical protein 0.0016 0.0106 0.011
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.1143 1
Chlamydia trachomatis hypothetical protein 0.0016 0.0106 0.5
Plasmodium falciparum mitogen-activated protein kinase phosphatase 1, putative 0.0016 0.0106 0.2558
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.1103 0.1214
Onchocerca volvulus 0.0068 0.1193 0.2943
Brugia malayi hypothetical protein 0.0068 0.1193 0.132
Echinococcus granulosus sex peptide receptor 0.0068 0.1193 0.1193
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0035 0.0502 0.0502
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0254 0.0254
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0205 0.4031 0.4031
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0203 0.4896
Echinococcus multilocularis neuropeptide receptor 0.0068 0.1193 0.1193
Echinococcus multilocularis neuropeptides capa receptor 0.0068 0.1193 0.1193
Schistosoma mansoni biogenic amine receptor 0.0068 0.1193 0.1193
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0254 0.0652
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Echinococcus multilocularis neuropeptide s receptor 0.0068 0.1193 0.1193
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Loa Loa (eye worm) fibroinase 0.002 0.0203 0.0217
Echinococcus multilocularis neuropeptide Y receptor 0.0068 0.1193 0.1193
Brugia malayi Rhodanese-like domain containing protein 0.0016 0.0106 0.0117
Schistosoma mansoni ap endonuclease 0.0023 0.0254 0.0254
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1103 0.1103
Echinococcus multilocularis neuropeptide Y receptor 0.0068 0.1193 0.1193
Onchocerca volvulus Cathepsin L homolog 0.002 0.0203 0.0361
Trichomonas vaginalis spcc417.12 protein, putative 0.0035 0.0502 0.1288
Loa Loa (eye worm) ctsf protein 0.002 0.0203 0.0217
Schistosoma mansoni myosin xvIII 0.0068 0.1193 0.1193
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0414 1
Brugia malayi CXXC zinc finger family protein 0.0035 0.0502 0.0555
Echinococcus multilocularis centrosomal protein of 41 kDa 0.0016 0.0106 0.0106
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0068 0.1193 0.1193
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0203 0.052
Loa Loa (eye worm) neuropeptide F receptor 0.0068 0.1193 0.1314
Onchocerca volvulus 0.0016 0.0106 0.0108
Schistosoma mansoni amine GPCR 0.0068 0.1193 0.1193
Onchocerca volvulus 0.002 0.0203 0.0361
Onchocerca volvulus 0.0199 0.3899 1
Echinococcus multilocularis neuroligin 0.0035 0.0502 0.0502
Brugia malayi Carboxylesterase family protein 0.0035 0.0502 0.0555
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0068 0.1193 0.1193
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0203 0.052
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Schistosoma mansoni neuropeptide F-like receptor 0.0068 0.1193 0.1193
Brugia malayi putative neuropeptide receptor 0.0068 0.1193 0.132
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.1193 0.1193
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.1193 0.1193
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.1193 0.1193
Entamoeba histolytica hypothetical protein 0.0016 0.0106 0.0272
Entamoeba histolytica rodhanase-like domain containing protein 0.0199 0.3899 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0068 0.1193 0.1193
Echinococcus multilocularis allatostatin A receptor 0.0068 0.1193 0.1193
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1306 0.1306
Brugia malayi hypothetical protein 0.0068 0.1193 0.132
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0203 0.052
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0035 0.0502 0.0502
Echinococcus granulosus peptide allatostatin:somatostatin 0.0068 0.1193 0.1193
Onchocerca volvulus 0.0199 0.3899 1
Loa Loa (eye worm) hypothetical protein 0.0199 0.3899 0.4309
Brugia malayi MoeZ/MoeB domain containing protein 0.0016 0.0106 0.0117
Echinococcus granulosus neuropeptides capa receptor 0.0068 0.1193 0.1193
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0203 0.0203
Echinococcus granulosus cpg binding protein 0.0037 0.0543 0.0543
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1378 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0068 0.1193 0.1193
Brugia malayi Cathepsin L-like precursor 0.0014 0.0065 0.0071
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1193 0.1193
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0203 0.1472
Echinococcus multilocularis BC026374 protein (S09 family) 0.0035 0.0502 0.0502
Brugia malayi Cathepsin L-like precursor 0.002 0.0203 0.0224
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1193 0.1193
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0199 0.3899 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0179 0.0179
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.1193 0.1193
Schistosoma mansoni neuropeptide F-like receptor 0.0068 0.1193 0.1193
Echinococcus multilocularis g protein coupled receptor 0.0068 0.1193 0.1193
Loa Loa (eye worm) hypothetical protein 0.0183 0.3578 0.3954
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1378 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0203 0.4896
Echinococcus granulosus dro:myosuppressin receptor 0.0068 0.1193 0.1193
Schistosoma mansoni ubiquitin-activating enzyme E1C 0.0016 0.0106 0.0106
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0203 0.4896
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0068 0.1193 0.132
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0068 0.1193 0.1314
Schistosoma mansoni hypothetical protein 0.0205 0.4017 0.4017
Schistosoma mansoni alpha-1 adrenergic receptor 0.0068 0.1193 0.1193
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0068 0.1193 0.1193
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0203 0.052
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Brugia malayi TAR-binding protein 0.0064 0.1103 0.122
Trichomonas vaginalis cdc25b, putative 0.0199 0.3899 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1193 0.1193
Schistosoma mansoni dual specificity protein phosphatase 0.0016 0.0106 0.0106
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0016 0.0106 0.0769
Onchocerca volvulus 0.0068 0.1193 0.2943
Echinococcus multilocularis neuropeptides capa receptor 0.0068 0.1193 0.1193
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1103 0.1103
Brugia malayi G protein-coupled receptor F59B2.13 0.0068 0.1193 0.132
Brugia malayi Dopamine receptor protein 1 0.0068 0.1193 0.132
Schistosoma mansoni cpg binding protein 0.0035 0.0502 0.0502
Schistosoma mansoni Centrosomal protein of 41 kDa (Cep41 protein) (Testis-specificprotein A14 protein) 0.0016 0.0106 0.0106
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0179 0.0576
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0016 0.0106 0.0769
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Echinococcus granulosus tm gpcr rhodopsin 0.0068 0.1193 0.1193
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Leishmania major cysteine peptidase A (CPA) 0.002 0.0203 0.0761
Trichomonas vaginalis Phage shock protein E precursor, putative 0.0016 0.0106 0.0272
Echinococcus granulosus neuropeptide Y receptor 0.0068 0.1193 0.1193
Schistosoma mansoni neuropeptide f receptor 76f 0.0068 0.1193 0.1193
Echinococcus granulosus acetylcholinesterase 0.0205 0.4031 0.4031
Brugia malayi Rhodanese-like domain containing protein 0.0016 0.0106 0.0117
Brugia malayi Cathepsin L-like precursor 0.002 0.0203 0.0224
Echinococcus multilocularis serotonin receptor 0.0068 0.1193 0.1193
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0068 0.1193 0.1193
Schistosoma mansoni hypothetical protein 0.0016 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0016 0.0106 0.011
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0732 0.0732
Loa Loa (eye worm) carboxylesterase 0.0035 0.0502 0.0549
Brugia malayi hypothetical protein 0.0068 0.1193 0.132
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0254 0.1166
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0203 0.0224
Entamoeba histolytica hypothetical protein 0.0016 0.0106 0.0272
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0035 0.0502 0.0502
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0254 0.0652
Brugia malayi RNA binding protein 0.0064 0.1103 0.122
Echinococcus multilocularis tar DNA binding protein 0.0064 0.1103 0.1103
Echinococcus granulosus alpha 1A adrenergic receptor 0.0068 0.1193 0.1193
Schistosoma mansoni fatty acid binding protein 0.0375 0.7549 0.7549
Mycobacterium leprae Probable thiosulfate sulfurtransferase SseA (RHODANESE) (THIOSULFATE CYANIDE TRANSSULFURASE) (THIOSULFATE THIOTRANSFERASE) 0.0016 0.0106 0.5
Leishmania major cathepsin L-like protease 0.002 0.0203 0.0761
Leishmania major cathepsin L-like protease 0.002 0.0203 0.0761
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0035 0.0502 0.1288
Leishmania major cathepsin L-like protease 0.002 0.0203 0.0761
Schistosoma mansoni neuropeptide receptor 0.0068 0.1193 0.1193
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Onchocerca volvulus Neuropeptide F receptor homolog 0.0068 0.1193 0.2943
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0203 0.0203
Schistosoma mansoni neuroligin 3 (S09 family) 0.0035 0.0502 0.0502
Loa Loa (eye worm) lipocalin/cytosolic fatty-acid binding protein family protein 0.0375 0.7549 0.835
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1193 0.1193
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0254 0.0652
Leishmania major cathepsin L-like protease 0.0077 0.1378 1
Trichomonas vaginalis cdc25c, putative 0.0016 0.0106 0.0272
Loa Loa (eye worm) cysteine protease 0.002 0.0203 0.0217
Echinococcus multilocularis dro:myosuppressin receptor 0.0068 0.1193 0.1193
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0203 0.052
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1378 1
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0106 0.0272
Brugia malayi hypothetical protein 0.0068 0.1193 0.132
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Echinococcus multilocularis muscleblind protein 1 0.0447 0.9039 0.9039
Trichomonas vaginalis cdc25b, putative 0.0199 0.3899 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0068 0.1193 0.1193
Schistosoma mansoni neuropeptide receptor 0.0068 0.1193 0.1193
Brugia malayi putative neuropeptide receptor NPR1 0.0068 0.1193 0.132
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0199 0.3899 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0068 0.1193 0.132
Onchocerca volvulus 0.0199 0.3899 1
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0016 0.0106 0.0769
Onchocerca volvulus 0.0035 0.0502 0.1141
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0732 0.0732
Brugia malayi GnHR receptor homolog 0.0068 0.1193 0.132
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0203 0.052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0203 0.052
Brugia malayi Cathepsin L-like precursor 0.002 0.0203 0.0224
Schistosoma mansoni hypothetical protein 0.0016 0.0106 0.0106
Trypanosoma brucei rhodanese-like domain containing protein, putative 0.0016 0.0106 0.0769
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0254 0.0254
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0179 0.4327
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0203 0.052
Entamoeba histolytica hypothetical protein, conserved 0.0016 0.0106 0.0272
Echinococcus multilocularis g protein coupled receptor 0.0068 0.1193 0.1193
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1378 1
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0254 0.0281
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0179 0.13
Echinococcus granulosus tm gpcr rhodopsin 0.0068 0.1193 0.1193
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0068 0.1193 0.1193
Brugia malayi hypothetical protein 0.0068 0.1193 0.132
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0203 0.052
Echinococcus granulosus biogenic amine 5HT receptor 0.0068 0.1193 0.1193
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0067 0.0067
Brugia malayi hypothetical protein 0.0035 0.0502 0.0555
Onchocerca volvulus 0.0182 0.3558 0.9112
Loa Loa (eye worm) hypothetical protein 0.0183 0.3578 0.3954
Echinococcus multilocularis neuropeptide FF receptor 2 0.0068 0.1193 0.1193
Echinococcus granulosus neuropeptides capa receptor 0.0068 0.1193 0.1193
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0016 0.0106 0.0769
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1193 0.1193
Echinococcus multilocularis sex peptide receptor 0.0068 0.1193 0.1193
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0106 0.0272
Trichomonas vaginalis thiosulfate sulfertansferase, putative 0.0016 0.0106 0.0272
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0179 0.1849
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0016 0.0106 0.0769
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0068 0.1193 0.1314
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0068 0.1193 0.1193
Entamoeba histolytica rodhanase-like domain containing protein 0.0016 0.0106 0.0272
Brugia malayi hypothetical protein 0.003 0.0414 0.0458
Echinococcus multilocularis fatty acid binding protein FABP2 0.0375 0.7549 0.7549
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.1103 0.122
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0068 0.1193 0.1193
Trypanosoma cruzi mercaptopyruvate sulfurtransferase, putative 0.0016 0.0106 0.0769
Trichomonas vaginalis cdc25a, putative 0.0016 0.0106 0.0272
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.1193 0.1193
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1378 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0068 0.1193 0.1193
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0203 0.052
Leishmania major cathepsin L-like protease 0.002 0.0203 0.0761
Echinococcus multilocularis acetylcholinesterase 0.0205 0.4031 0.4031
Plasmodium vivax vivapain-2 0.002 0.0203 0.4896
Loa Loa (eye worm) hypothetical protein 0.0035 0.0502 0.0549
Brugia malayi Carboxylesterase family protein 0.0035 0.0502 0.0555
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0414 1
Onchocerca volvulus 0.0068 0.1193 0.2943
Onchocerca volvulus 0.0068 0.1193 0.2943
Brugia malayi Thiosulfate sulfurtransferase D2023.5 0.0016 0.0106 0.0117
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0068 0.1193 0.1193
Onchocerca volvulus 0.0035 0.0502 0.1141
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0035 0.0502 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0068 0.1193 0.2943
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Onchocerca volvulus 0.002 0.0203 0.0361
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0203 0.052
Echinococcus granulosus 5'partial|tRNA 2 selenouridine synthase 0.0016 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Brugia malayi larval opioid receptor 0.0068 0.1193 0.132
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0106 0.0769
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Echinococcus multilocularis geminin 0.0205 0.4017 0.4017
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.1193 0.1193
Echinococcus multilocularis cysteine protease 0.002 0.0203 0.0203
Echinococcus multilocularis cpg binding protein 0.0037 0.0543 0.0543
Echinococcus multilocularis orexin receptor type 2 0.0068 0.1193 0.1193
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0254 0.1845
Echinococcus granulosus allatostatin A receptor 0.0068 0.1193 0.1193
Onchocerca volvulus Cathepsin L homolog 0.002 0.0203 0.0361
Leishmania major cathepsin L-like protease 0.0077 0.1378 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Schistosoma mansoni acetylcholinesterase 0.0035 0.0502 0.0502
Loa Loa (eye worm) thiosulfate sulfurtransferase 0.0016 0.0106 0.011
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0203 0.0203
Echinococcus multilocularis somatostatin receptor 0.0068 0.1193 0.1193
Entamoeba histolytica cysteine protease, putative 0.002 0.0203 0.052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0203 0.052
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0179 0.4327
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0016 0.0106 0.0769
Onchocerca volvulus 0.0068 0.1193 0.2943
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0068 0.1193 0.1193
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0068 0.1193 0.132
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0203 0.052
Brugia malayi Rhodanese-like domain containing protein 0.0199 0.3899 0.4314
Loa Loa (eye worm) melatonin receptor type 1A 0.0068 0.1193 0.1314
Trypanosoma cruzi As/Sb Reductase, putative 0.0016 0.0106 0.0769
Loa Loa (eye worm) TAR-binding protein 0.0064 0.1103 0.1214
Onchocerca volvulus Cathepsin F homolog 0.002 0.0203 0.0361
Brugia malayi hypothetical protein 0.0068 0.1193 0.132
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0006 0.0006
Brugia malayi Dopamine receptor 0.0068 0.1193 0.132
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0004 0.0004
Onchocerca volvulus 0.0068 0.1193 0.2943
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0068 0.1193 0.1193
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0068 0.1193 0.1193
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0016 0.0106 0.0272
Loa Loa (eye worm) hypothetical protein 0.002 0.0203 0.0217
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0203 0.052
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1103 0.1103
Loa Loa (eye worm) G-protein coupled receptor 0.0068 0.1193 0.1314
Schistosoma mansoni hypothetical protein 0.0068 0.1193 0.1193
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0203 0.052
Echinococcus granulosus tm gpcr rhodopsin 0.0068 0.1193 0.1193
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0106 0.0272
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Echinococcus granulosus g protein coupled receptor 0.0068 0.1193 0.1193
Brugia malayi Serotonin receptor 0.0068 0.1193 0.132
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.1193 0.1193
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0203 0.0217
Schistosoma mansoni hypothetical protein 0.0014 0.0067 0.0067
Onchocerca volvulus 0.0035 0.0502 0.1141
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Entamoeba histolytica hypothetical protein 0.0016 0.0106 0.0272
Loa Loa (eye worm) hypothetical protein 0.0016 0.0106 0.011
Onchocerca volvulus 0.0199 0.3899 1
Mycobacterium leprae PROBABLE THIOSULFATE SULFURTRANSFERASE CYSA2 (RHODANESE-LIKE PROTEIN) (THIOSULFATE CYANIDE TRANSSULFURASE) (THIOSULFATE THIOTRAN 0.0016 0.0106 0.5
Loa Loa (eye worm) hypothetical protein 0.0068 0.1193 0.1314
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.1193 0.1193
Schistosoma mansoni ubiquitin-activating enzyme E1 0.0016 0.0106 0.0106
Echinococcus granulosus neuropeptide Y receptor 0.0068 0.1193 0.1193
Onchocerca volvulus 0.0068 0.1193 0.2943
Mycobacterium tuberculosis Carboxylesterase LipT 0.0035 0.0502 1
Echinococcus multilocularis neuropeptide receptor A26 0.0068 0.1193 0.1193

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) = 38 % Cytotoxicity against HEK293 cells assessed as cell viability at 100 uM after 24 hrs by MTT assay relative to control ChEMBL. 23374014
IC50 (binding) > 100 uM Inhibition of recombinant BACE1 (unknown origin) using FAM-SEVNLDAEFK-TAMRA as substrate incubated for 30 mins prior to substrate addition by fluorimetric analysis ChEMBL. 23374014
Inhibition (binding) = 34.4 % Inhibition of recombinant BACE1 (unknown origin) using FAM-SEVNLDAEFK-TAMRA as substrate at 100 uM incubated for 30 mins prior to substrate addition by fluorimetric analysis relative to control ChEMBL. 23374014

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.