Detailed information for compound 1726789

Basic information

Technical information
  • TDR Targets ID: 1726789
  • Name: 2,3-bis(4-chlorophenyl)quinoxaline-6-carboxyl ic acid
  • MW: 395.238 | Formula: C21H12Cl2N2O2
  • H donors: 1 H acceptors: 4 LogP: 5.31 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)c1nc2cc(ccc2nc1c1ccc(cc1)Cl)C(=O)O
  • InChi: 1S/C21H12Cl2N2O2/c22-15-6-1-12(2-7-15)19-20(13-3-8-16(23)9-4-13)25-18-11-14(21(26)27)5-10-17(18)24-19/h1-11H,(H,26,27)
  • InChiKey: HWARRBNHGPIIKB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2,3-bis(4-chlorophenyl)-6-quinoxalinecarboxylic acid
  • Oprea1_101784
  • 2,3-Bis-(4-chloro-phenyl)-quinoxaline-6-carboxylic acid
  • BAS 00428139
  • CBDivE_011278
  • Oprea1_657289

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens transcription factor 7-like 2 (T-cell specific, HMG-box) References
Homo sapiens catenin (cadherin-associated protein), beta 1, 88kDa References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Armadillo/beta-catenin-like repeat family protein Get druggable targets OG5_130404 All targets in OG5_130404
Schistosoma mansoni pangolin Get druggable targets OG5_131559 All targets in OG5_131559
Echinococcus multilocularis protein pangolin J Get druggable targets OG5_131559 All targets in OG5_131559
Onchocerca volvulus Cirhin homolog Get druggable targets OG5_130404 All targets in OG5_130404
Loa Loa (eye worm) HMP-2 protein Get druggable targets OG5_130404 All targets in OG5_130404
Schistosoma mansoni beta-catenin Get druggable targets OG5_130404 All targets in OG5_130404
Loa Loa (eye worm) HMG box family protein Get druggable targets OG5_131559 All targets in OG5_131559
Brugia malayi HMG box family protein Get druggable targets OG5_131559 All targets in OG5_131559
Echinococcus granulosus pangolin Get druggable targets OG5_131559 All targets in OG5_131559
Schistosoma japonicum ko:K02105 catenin (cadherin-associated protein), beta 1, putative Get druggable targets OG5_130404 All targets in OG5_130404
Echinococcus granulosus hypothetical protein Get druggable targets OG5_131559 All targets in OG5_131559
Schistosoma japonicum expressed protein Get druggable targets OG5_130404 All targets in OG5_130404
Echinococcus granulosus beta catenin Get druggable targets OG5_130404 All targets in OG5_130404
Echinococcus multilocularis T cell transcription factor 4 long C terminal Get druggable targets OG5_131559 All targets in OG5_131559
Echinococcus multilocularis beta catenin Get druggable targets OG5_130404 All targets in OG5_130404
Schistosoma japonicum Catenin beta-1, putative Get druggable targets OG5_130404 All targets in OG5_130404
Schistosoma japonicum ko:K04491 transcription factor 7-like 2, putative Get druggable targets OG5_131559 All targets in OG5_131559
Echinococcus granulosus T cell transcription factor 4 long C terminal Get druggable targets OG5_131559 All targets in OG5_131559
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0079 0.0074
Schistosoma mansoni coup transcription factor 0.001 0.0031 0.0026
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0079 0.0412
Echinococcus granulosus ETS transcription factor Elf 5 0.0012 0.0043 0.0037
Schistosoma mansoni hypothetical protein 0.0033 0.0197 0.0191
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0134 0.0715
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0134 0.0716
Echinococcus granulosus ETS transcription factor Elf 2 0.0012 0.0043 0.0037
Brugia malayi Cathepsin L-like precursor 0.0017 0.0079 0.0428
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.019 0.0185
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0031 0.0149
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0079 0.0412
Entamoeba histolytica cysteine protease, putative 0.0017 0.0079 0.2268
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0026 0.0117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0284 0.1553
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0079 0.0412
Loa Loa (eye worm) hypothetical protein 0.0032 0.019 0.1066
Loa Loa (eye worm) CAMK/CAMKL/PASK protein kinase 0.0055 0.0355 0.2018
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0009 0.0026 0.028
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0031 0.0149
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0079 0.0074
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0008 0.0019 0.0081
Entamoeba histolytica cysteine protease, putative 0.0009 0.002 0.0037
Leishmania major cathepsin L-like protease 0.0017 0.0079 0.0347
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0039 0.0188
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0284 0.6121
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.002 0.0015
Onchocerca volvulus 0.0011 0.0039 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0237 0.1287
Loa Loa (eye worm) TAR-binding protein 0.0141 0.0984 0.565
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0245 0.8528
Echinococcus granulosus ferritin 0.0054 0.0351 0.0346
Mycobacterium ulcerans bacterioferritin BfrA 0.0054 0.0351 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0422 1
Schistosoma mansoni beta-catenin 0.0116 0.0799 0.0795
Giardia lamblia GTOR 0.0045 0.0284 1
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0079 0.0273
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0045 0.0222
Leishmania major cathepsin L-like protease 0.0064 0.0422 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0031 0.0149
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0422 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0067 0.0357
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0067 0.0062
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0271 0.0266
Entamoeba histolytica cysteine protease, putative 0.0009 0.002 0.0037
Loa Loa (eye worm) acetyltransferase 0.0147 0.1025 0.5886
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0031 0.0149
Echinococcus granulosus beta catenin 0.0116 0.0799 0.0795
Loa Loa (eye worm) HMG box family protein 0.0077 0.052 0.2972
Echinococcus granulosus expressed protein 0.0054 0.0351 0.0346
Schistosoma mansoni hypothetical protein 0.0033 0.0197 0.0191
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0079 0.0428
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0008 0.0019 0.0459
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0153 0.0821
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0079 0.2268
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0039 0.0747
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0284 1
Echinococcus multilocularis protein pangolin J 0.0077 0.052 0.0515
Echinococcus multilocularis ETS transcription factor Elf 1 0.0012 0.0043 0.0037
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0271 1
Brugia malayi Cathepsin L-like precursor 0.0011 0.0039 0.0195
Entamoeba histolytica cysteine protease, putative 0.0009 0.002 0.0037
Entamoeba histolytica cysteine protease, putative 0.0009 0.002 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0079 0.0412
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0031 0.0026
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.0713 0.4083
Echinococcus multilocularis expressed protein 0.0054 0.0351 0.0346
Schistosoma mansoni ferritin 0.0054 0.0351 0.0346
Echinococcus granulosus ETS transcription factor Elf 2 0.0012 0.0043 0.0037
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0079 0.0074
Schistosoma mansoni ets-related 0.0012 0.0043 0.0037
Echinococcus multilocularis ETS transcription factor Elf 2 0.0012 0.0043 0.0037
Schistosoma mansoni pangolin 0.0077 0.052 0.0515
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0197 0.1103
Echinococcus granulosus cysteine protease 0.0009 0.002 0.0015
Schistosoma mansoni ferritin 0.0054 0.0351 0.0346
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0422 1
Brugia malayi Pre-SET motif family protein 0.0032 0.019 0.1066
Entamoeba histolytica cysteine protease, putative 0.0009 0.002 0.0037
Entamoeba histolytica cysteine protease, putative 0.0009 0.002 0.0037
Entamoeba histolytica cysteine proteinase 2 0.0009 0.002 0.0037
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0195
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0031 0.0026
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.019 0.0185
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.019 0.6769
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0012 0.0043 0.0215
Trichomonas vaginalis PIKK family atypical protein kinase 0.0008 0.0019 0.0078
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0201 0.1087
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0031 0.0026
Trypanosoma cruzi cysteine proteinase, putative 0.0009 0.002 0.0024
Echinococcus multilocularis thyroid hormone receptor alpha 0.0136 0.0948 0.0943
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0079 0.0273
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0054 0.0351 0.5
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0195
Entamoeba histolytica cysteine proteinase, putative 0.0009 0.002 0.0037
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0245 1
Echinococcus multilocularis GPCR, family 2 0.0033 0.0197 0.0191
Brugia malayi Papain family cysteine protease containing protein 0.0009 0.002 0.0087
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0031 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0079 0.0412
Brugia malayi Fli-1 protein 0.0244 0.1738 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0008 0.0019 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0031 0.0149
Onchocerca volvulus 0.0055 0.0355 0.1829
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0031 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0151 0.081
Entamoeba histolytica cysteine protease, putative 0.0009 0.002 0.0037
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0079 0.2627
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0067 0.0062
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0284 0.6738
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.0009 0.0024 0.0109
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0008 0.0019 0.0014
Schistosoma mansoni hypothetical protein 0.0126 0.0874 0.0869
Onchocerca volvulus 0.0017 0.0079 0.0273
Entamoeba histolytica cysteine protease, putative 0.0009 0.002 0.0037
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.019 0.0185
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.019 0.0185
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0197 0.0191
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.1025 0.5886
Echinococcus granulosus ETS domain containing protein Elk 1 0.0012 0.0043 0.0037
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0031 0.0026
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0079 0.0074
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.002 0.0015
Onchocerca volvulus 0.0017 0.0079 0.0273
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0422 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0079 0.0412
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0284 0.6121
Echinococcus multilocularis tar DNA binding protein 0.0141 0.0984 0.098
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0284 0.6738
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0012 0.0043 0.0037
Loa Loa (eye worm) fibroinase 0.0017 0.0079 0.0428
Echinococcus granulosus tar DNA binding protein 0.0141 0.0984 0.098
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.017 0.0915
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0197 0.0191
Brugia malayi Cathepsin L-like precursor 0.0017 0.0079 0.0428
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0031 0.0149
Schistosoma mansoni hypothetical protein 0.0071 0.0474 0.0469
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0031 0.0026
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0054 0.0351 0.5
Echinococcus multilocularis ewsr:fli fusion protein type 0.0012 0.0043 0.0037
Brugia malayi RNA binding protein 0.0141 0.0984 0.565
Echinococcus granulosus serine protein kinase ATM 0.0008 0.0019 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0031 0.0149
Onchocerca volvulus Cirhin homolog 0.0115 0.0794 0.4306
Echinococcus granulosus protein C ets 2 0.0012 0.0043 0.0037
Echinococcus multilocularis ets variant gene 4 0.0012 0.0043 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0134 0.0715
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0197 0.0191
Brugia malayi ecdysteroid receptor 0.001 0.0031 0.0149
Schistosoma mansoni nuclear hormone receptor 0.001 0.0031 0.0026
Leishmania major cathepsin L-like protease 0.0017 0.0079 0.0347
Brugia malayi Cathepsin L-like precursor 0.0011 0.0039 0.0195
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0031 0.0149
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0031 0.0026
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0079 0.0412
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0149
Echinococcus granulosus ewsr:fli fusion protein type 0.0012 0.0043 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0031 0.0149
Schistosoma mansoni ets-related 0.0244 0.1738 0.1734
Loa Loa (eye worm) hypothetical protein 0.0008 0.0019 0.0081
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0079 0.0412
Trichomonas vaginalis set domain proteins, putative 0.0253 0.1802 1
Entamoeba histolytica cysteine protease, putative 0.0009 0.002 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0217 0.1181
Echinococcus multilocularis serine protein kinase ATM 0.0008 0.0019 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0031 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0217 0.1181
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0031 0.0149
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.1025 0.102
Loa Loa (eye worm) hypothetical protein 0.0071 0.0474 0.2704
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0031 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0284 0.1553
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0031 0.0026
Echinococcus multilocularis cathepsin L 0.0009 0.002 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0067 0.0344
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0201 0.1087
Loa Loa (eye worm) HMP-2 protein 0.0116 0.0799 0.4584
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0008 0.0019 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.002 0.0084
Entamoeba histolytica cysteine protease, putative 0.0009 0.002 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0008 0.0019 0.0078
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.008 0.0544 0.3109
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0079 0.2627
Brugia malayi cathepsin L-like precursor 0.0011 0.0039 0.0195
Schistosoma mansoni thyroid hormone receptor 0.0136 0.0948 0.0943
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0197 0.1103
Echinococcus granulosus pangolin 0.0077 0.052 0.0515
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0201 0.1087
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0067 0.1591
Echinococcus granulosus T cell transcription factor 4 long C terminal 0.0077 0.052 0.0515
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.0009 0.0026 0.0122
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0197 0.0191
Schistosoma mansoni apoferritin-2 0.0054 0.0351 0.0346
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.019 0.0185
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0149
Echinococcus multilocularis cysteine protease 0.0017 0.0079 0.0074
Schistosoma mansoni fkbp-rapamycin associated protein 0.0008 0.0019 0.0014
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0031 0.0026
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0422 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0031 0.0026
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0079 0.0428
Onchocerca volvulus 0.0017 0.0079 0.0273
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0067 0.0344
Schistosoma mansoni hypothetical protein 0.0033 0.0197 0.0191
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0079 0.0412
Leishmania major cathepsin L-like protease 0.0017 0.0079 0.0347
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0079 0.0412
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0079 0.0074
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0201 0.7188
Loa Loa (eye worm) RNA binding protein 0.0141 0.0984 0.565
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0382 0.8999
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0422 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0197 0.1103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0201 0.1087
Entamoeba histolytica cysteine proteinase, putative 0.0009 0.002 0.0037
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0422 1
Brugia malayi RNA recognition motif domain containing protein 0.0141 0.0984 0.565
Plasmodium vivax vivapain-2 0.0017 0.0079 0.2353
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0067 0.0357
Schistosoma mansoni tar DNA-binding protein 0.0141 0.0984 0.098
Loa Loa (eye worm) ets-domain-containing protein 0.0012 0.0043 0.0215
Brugia malayi DNA-binding protein D-ETS-3 0.0012 0.0043 0.0215
Leishmania major cathepsin L-like protease 0.0017 0.0079 0.0347
Echinococcus multilocularis GA binding protein alpha chain 0.008 0.0544 0.0539
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0323 0.7531
Echinococcus multilocularis protein C ets 2 0.0012 0.0043 0.0037
Schistosoma mansoni tar DNA-binding protein 0.0141 0.0984 0.098
Loa Loa (eye worm) hypothetical protein 0.0033 0.0197 0.1103
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0031 0.0026
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0079 0.0074
Echinococcus multilocularis T cell transcription factor 4 long C terminal 0.0077 0.052 0.0515
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0474 0.2704
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0079 0.0412
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0284 0.161
Schistosoma mansoni tar DNA-binding protein 0.0141 0.0984 0.098
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0284 0.0279
Brugia malayi nuclear receptor NHR-88 0.001 0.0031 0.0149
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0031 0.0026
Schistosoma mansoni hypothetical protein 0.0012 0.0043 0.0037
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0195
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.019 0.0185
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0422 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0008 0.0019 0.0081
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0284 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0218 0.516
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0271 0.1481
Brugia malayi HMG box family protein 0.0077 0.052 0.2972
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0031 0.0026
Schistosoma mansoni hypothetical protein 0.0281 0.2007 0.2003
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.0422 1
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0079 0.2268
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.002 0.0015
Onchocerca volvulus 0.0017 0.0079 0.0273
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0067 0.0344
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0422 1
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0079 0.0347
Loa Loa (eye worm) hypothetical protein 0.0012 0.0043 0.0215
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0134 0.0716
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0031 0.0149
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0079 0.0412
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0177 0.0954
Loa Loa (eye worm) D-ets-2 protein 0.0012 0.0043 0.0215
Onchocerca volvulus 0.0017 0.0079 0.0273
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.0995 0.099
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0009 0.002 0.0482
Loa Loa (eye worm) hypothetical protein 0.0012 0.0043 0.0215
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0079 0.0412
Trichomonas vaginalis ferritin, putative 0.0054 0.0351 0.1923
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.002 0.0084
Entamoeba histolytica cysteine proteinase, putative 0.0009 0.002 0.0037
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0031 0.0026
Loa Loa (eye worm) fli-1 protein 0.0244 0.1738 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0149
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0009 0.002 0.0482
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.1025 0.102
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0126 0.0874 0.0869
Schistosoma mansoni gabp alpha 0.008 0.0544 0.0539
Echinococcus granulosus cathepsin L 0.0009 0.002 0.0015
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0031 0.0149
Brugia malayi steroid hormone receptor 0.001 0.0031 0.0149
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0422 1
Onchocerca volvulus 0.0017 0.0079 0.0273
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0271 1
Echinococcus granulosus GPCR family 2 0.0033 0.0197 0.0191
Schistosoma mansoni ferritin light chain 0.0054 0.0351 0.0346
Schistosoma mansoni ferritin light chain 0.0054 0.0351 0.0346
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0284 0.1553
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0422 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0009 0.002 0.0037
Trypanosoma cruzi cysteine peptidase, putative 0.0009 0.002 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0031 0.0149
Schistosoma mansoni ferritin 0.0054 0.0351 0.0346
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0031 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0079 0.0412
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0031 0.0149
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0031 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0079 0.0412
Entamoeba histolytica cysteine protease, putative 0.0009 0.002 0.0037
Brugia malayi transcription factor E74 isoform 0.0012 0.0043 0.0215
Treponema pallidum bacterioferrin (TpF1) 0.0054 0.0351 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0079 0.0412
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0149
Echinococcus granulosus cathepsin l1 0.0011 0.0039 0.0034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0079 0.0412
Brugia malayi Papain family cysteine protease containing protein 0.0009 0.002 0.0087
Schistosoma mansoni apoferritin-2 0.0054 0.0351 0.0346
Loa Loa (eye worm) hypothetical protein 0.0069 0.0459 0.2618
Echinococcus multilocularis ETS transcription factor Elf 2 0.0012 0.0043 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0067 0.0344
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0031 0.0149
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0031 0.0026
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0067 0.1187
Onchocerca volvulus 0.0253 0.1802 1
Onchocerca volvulus 0.0017 0.0079 0.0273
Brugia malayi nuclear hormone receptor 0.001 0.0031 0.0149
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0126 0.0874 0.0869
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0079 0.0412
Echinococcus granulosus ETS transcription factor Elf 1 0.0012 0.0043 0.0037
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0031 0.0149
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0067 0.1591
Brugia malayi Armadillo/beta-catenin-like repeat family protein 0.0116 0.0799 0.4584
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0031 0.0149
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0012 0.0043 0.0215
Echinococcus granulosus GA binding protein alpha chain 0.008 0.0544 0.0539
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0067 0.0344
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0039 0.0188
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0079 0.0273
Brugia malayi Cathepsin L-like precursor 0.0017 0.0079 0.0428
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0284 0.6581
Schistosoma mansoni ets 0.0012 0.0043 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0079 0.0412
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0218 0.4244
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0031 0.0149
Loa Loa (eye worm) hypothetical protein 0.0017 0.0079 0.0428
Brugia malayi Ets-domain containing protein 0.0012 0.0043 0.0215
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0217 0.1181
Schistosoma mansoni thyroid hormone receptor 0.0136 0.0948 0.0943
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0039 0.0034
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0222 0.1578 0.9079
Loa Loa (eye worm) hypothetical protein 0.0104 0.0713 0.4083
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0054 0.0351 0.5
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0031 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0079 0.0412
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0067 0.1187
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0067 0.0062
Brugia malayi Ets-domain containing protein 0.008 0.0544 0.3109
Echinococcus granulosus FTZ F1 alpha 0.001 0.0031 0.0026
Entamoeba histolytica cysteine protease, putative 0.0009 0.002 0.0037
Loa Loa (eye worm) cysteine protease 0.0017 0.0079 0.0428
Brugia malayi Ets-domain containing protein 0.008 0.0544 0.3109
Trypanosoma cruzi cysteine protease, putative 0.0009 0.002 0.0024
Echinococcus granulosus hypothetical protein 0.0358 0.2565 0.2561
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.019 0.0185
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0079 0.0412
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0422 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0218 0.4927
Trypanosoma cruzi cysteine proteinase, putative 0.0009 0.002 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0079 0.0412
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0271 1
Entamoeba histolytica cysteine proteinase, putative 0.0009 0.002 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0134 0.0716
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0201 0.1087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0031 0.0149
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0079 0.0074
Leishmania major cathepsin L-like protease 0.0017 0.0079 0.0347
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0079 0.0412
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0031 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0201 0.1087
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0039 0.0195
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0079 0.0412
Brugia malayi Cathepsin L-like precursor 0.0017 0.0079 0.0428
Schistosoma mansoni elf1 0.0012 0.0043 0.0037
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0284 0.0279
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0284 0.6581
Brugia malayi TAR-binding protein 0.0141 0.0984 0.565
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0079 0.2627
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0217 0.1181
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0149
Leishmania major cathepsin L-like protease 0.0064 0.0422 1
Echinococcus granulosus cathepsin L cysteine protease 0.0009 0.002 0.0015
Plasmodium vivax SET domain protein, putative 0.0032 0.019 0.6757
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0153 0.0821
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0054 0.0351 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0079 0.0412
Echinococcus multilocularis ferritin 0.0054 0.0351 0.0346
Schistosoma mansoni ferritin 0.0054 0.0351 0.0346
Schistosoma mansoni tar DNA-binding protein 0.0141 0.0984 0.098
Brugia malayi Pre-SET motif family protein 0.0222 0.1578 0.9079
Echinococcus multilocularis beta catenin 0.0116 0.0799 0.0795
Schistosoma mansoni tar DNA-binding protein 0.0141 0.0984 0.098
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0284 0.0279
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0031 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0031 0.0149
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0031 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0217 0.1181
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0009 0.002 0.0024
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0149
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0271 0.1481
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0134 0.0716
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0112 0.2656
Schistosoma mansoni hypothetical protein 0.0012 0.0043 0.0037
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0079 0.0428
Brugia malayi Cathepsin L-like precursor 0.0017 0.0079 0.0428
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.0713 0.4083
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0134 0.0715
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0012 0.0043 0.0037
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0284 0.161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0151 0.081
Entamoeba histolytica cysteine protease, putative 0.0009 0.002 0.0037
Loa Loa (eye worm) ctsf protein 0.0017 0.0079 0.0428
Onchocerca volvulus 0.0032 0.019 0.0897
Toxoplasma gondii cathepsin CPL 0.0017 0.0079 0.2383
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0031 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0153 0.0821
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0031 0.0149
Brugia malayi Cathepsin L-like precursor 0.0017 0.0079 0.0428
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0079 0.1492
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0079 0.0074
Schistosoma mansoni hypothetical protein 0.0033 0.0197 0.0191
Mycobacterium ulcerans bacterioferritin BfrB 0.0054 0.0351 0.5
Echinococcus multilocularis ETS transcription factor Elf 5 0.0012 0.0043 0.0037
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0141 0.0984 0.565
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0181 0.0176
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0031 0.0026
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0422 1
Echinococcus multilocularis cysteine protease 0.0017 0.0079 0.0074
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0008 0.0019 0.0014
Echinococcus granulosus cathepsin l1 0.0017 0.0079 0.0074
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0093 0.221
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.0713 0.4083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0201 0.1087
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0422 1
Leishmania major cathepsin L-like protease 0.0064 0.0422 1
Plasmodium vivax vivapain-2 0.0017 0.0079 0.2353

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 38 uM Cytotoxicity against human SW480 cells assessed as inhibition of cell growth after 72 hrs by MTS assay ChEMBL. 25985283
Ki (binding) = 8.8 uM Inhibition of human wild-type beta-catenin (residues 138-686)/C-terminally fluorescein labeled human wild-type Tcf4 (residues 7-51) interaction after 1.5 hrs by FP competitive inhibition assay ChEMBL. 25985283
Ki (binding) = 8.8 uM Inhibition of human beta-casein/Tcf4 interaction after 1 hr by fluorescence polarization assay ChEMBL. 24900664
Ki (binding) = 13 uM Inhibition of N-terminally His6-tagged human beta-catenin (residues 138-686)/C-terminally biotinylated human Tcf4 (residues 7-51) interaction after 45 mins by AlphaScreen competitive inhibition assay ChEMBL. 25985283
Ki (binding) = 13 uM Inhibition of human beta-casein/Tcf4 interaction after 1 hr by alphascreen assay ChEMBL. 24900664
Ki (binding) = 69 uM Inhibition of human beta-casein/APC-R3 interaction after 1 hr by fluorescence polarization assay ChEMBL. 24900664
Ki (binding) = 71 uM Inhibition of human beta-casein/APC-R3 interaction after 1 hr by alphascreen assay ChEMBL. 24900664

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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