Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | gpi ethanolamine phosphate transferase 3 | 0.0063 | 0.0335 | 0.0335 |
Schistosoma mansoni | hypothetical protein | 0.0089 | 0.0621 | 0.057 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0089 | 0.0621 | 0.0621 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0251 | 0.0285 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0335 | 0.038 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0251 | 0.0251 |
Schistosoma mansoni | endonuclease related | 0.0239 | 0.2213 | 0.2402 |
Brugia malayi | beta-lactamase | 0.0043 | 0.0127 | 0.0103 |
Onchocerca volvulus | 0.0398 | 0.3904 | 0.4349 | |
Schistosoma mansoni | hypothetical protein | 0.0089 | 0.0621 | 0.057 |
Trypanosoma cruzi | endonuclease G, putative | 0.0239 | 0.2213 | 1 |
Echinococcus granulosus | lamin | 0.0065 | 0.0356 | 0.0911 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0239 | 0.2213 | 1 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0043 | 0.0127 | 0.0149 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0335 | 0.3238 | 0.3238 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0044 | 0.0139 | 0.0587 |
Loa Loa (eye worm) | type I phosphodiesterase/nucleotide pyrophosphatase | 0.0063 | 0.0335 | 0.038 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1727 | 0.196 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0089 | 0.0621 | 0.0621 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0335 | 0.038 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0398 | 0.3904 | 1 |
Echinococcus granulosus | gpi ethanolamine phosphate transferase 3 | 0.0063 | 0.0335 | 0.0857 |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.3904 | 0.443 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0283 | 0.2681 | 0.3042 |
Onchocerca volvulus | 0.0106 | 0.0801 | 0.0777 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0251 | 0.0643 |
Loa Loa (eye worm) | inositol-1 | 0.0044 | 0.0139 | 0.0158 |
Schistosoma mansoni | survival motor neuron protein | 0.0058 | 0.0283 | 0.018 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.012 | 0.0944 | 0.0941 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0043 | 0.0127 | 0.0326 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0398 | 0.3904 | 0.3904 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0335 | 0.038 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0251 | 0.0143 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0398 | 0.3904 | 1 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0858 | 0.8812 | 1 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0044 | 0.0139 | 0.0139 |
Brugia malayi | Trypsin family protein | 0.012 | 0.0944 | 0.1034 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0044 | 0.0139 | 0.5 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0043 | 0.0127 | 0.0149 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0127 | 0.0144 |
Echinococcus multilocularis | transferase | 0.0063 | 0.0335 | 0.0335 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0.0127 | 0.5 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0398 | 0.3904 | 0.4349 |
Giardia lamblia | Phosphatidylinositol-glycan biosynthesis, class O protein | 0.0063 | 0.0335 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0398 | 0.3904 | 0.3904 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0063 | 0.0335 | 0.0857 |
Echinococcus multilocularis | musashi | 0.0065 | 0.0356 | 0.0356 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0398 | 0.3904 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0044 | 0.0139 | 0.0014 |
Mycobacterium leprae | hypothetical protein | 0.0063 | 0.0335 | 1 |
Leishmania major | DNA/RNA non-specific endonuclease-like protein | 0.0239 | 0.2213 | 1 |
Toxoplasma gondii | DNA/RNA non-specific endonuclease | 0.0239 | 0.2213 | 1 |
Brugia malayi | hypothetical protein | 0.0063 | 0.0335 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.0944 | 0.1071 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0044 | 0.0139 | 0.0057 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0398 | 0.3904 | 0.3904 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0398 | 0.3904 | 0.3904 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0044 | 0.0139 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0283 | 0.2681 | 0.3043 |
Brugia malayi | hypothetical protein | 0.0283 | 0.2681 | 0.3014 |
Brugia malayi | Inositol-1 | 0.0044 | 0.0139 | 0.0117 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0251 | 0.0143 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0398 | 0.3904 | 0.3904 |
Brugia malayi | endonuclease G, mitochondrial precursor | 0.0239 | 0.2213 | 0.248 |
Onchocerca volvulus | Ectonucleotide pyrophosphatase\/phosphodiesterase family member 6 homolog | 0.0063 | 0.0335 | 0.0239 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.0944 | 0.1071 |
Mycobacterium tuberculosis | Conserved protein | 0.0043 | 0.0127 | 0.0149 |
Brugia malayi | intermediate filament protein | 0.0065 | 0.0356 | 0.0364 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0065 | 0.0356 | 0.0364 |
Schistosoma mansoni | hypothetical protein | 0.0089 | 0.0621 | 0.057 |
Onchocerca volvulus | Ectonucleotide pyrophosphatase\/phosphodiesterase family member 7 homolog | 0.0063 | 0.0335 | 0.0239 |
Trypanosoma cruzi | endonuclease G, putative | 0.0239 | 0.2213 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0127 | 0.0144 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0044 | 0.0139 | 0.0057 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.0127 | 0.0325 |
Schistosoma mansoni | hypothetical protein | 0.0063 | 0.0335 | 0.0239 |
Mycobacterium tuberculosis | Conserved protein | 0.0043 | 0.0127 | 0.0149 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0043 | 0.0127 | 0.0144 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0398 | 0.3904 | 0.4349 |
Echinococcus granulosus | intermediate filament protein | 0.0065 | 0.0356 | 0.0911 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0043 | 0.0127 | 0.0149 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0127 | 0.0103 |
Onchocerca volvulus | 0.0065 | 0.0356 | 0.0263 | |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.3904 | 0.443 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0063 | 0.0335 | 0.0335 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0127 | 0.0144 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0089 | 0.0621 | 0.0667 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0127 | 0.0144 |
Onchocerca volvulus | 0.0058 | 0.0283 | 0.0179 | |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.0398 | 0.3904 | 0.4407 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0251 | 0.0251 |
Echinococcus multilocularis | gpi ethanolamine phosphate transferase 1 | 0.0063 | 0.0335 | 0.0335 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0058 | 0.0283 | 0.0281 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0089 | 0.0621 | 0.0667 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0065 | 0.0356 | 0.0403 |
Echinococcus granulosus | transferase | 0.0063 | 0.0335 | 0.0857 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0239 | 0.2213 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0356 | 0.0403 |
Schistosoma mansoni | hypothetical protein | 0.0063 | 0.0335 | 0.0239 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.0127 | 0.0103 |
Onchocerca volvulus | 0.012 | 0.0944 | 0.094 | |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0127 | 0.0103 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0044 | 0.0139 | 0.0057 |
Echinococcus multilocularis | lamin | 0.0065 | 0.0356 | 0.0356 |
Schistosoma mansoni | inositol monophosphatase | 0.0044 | 0.0139 | 0.0014 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0044 | 0.0139 | 0.0057 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0063 | 0.0335 | 0.0239 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0398 | 0.3904 | 0.3904 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0193 | 0.1727 | 0.1927 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0335 | 0.038 |
Onchocerca volvulus | 0.0065 | 0.0356 | 0.0263 | |
Schistosoma mansoni | intermediate filament proteins | 0.0065 | 0.0356 | 0.0263 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0043 | 0.0127 | 0.0149 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0044 | 0.0139 | 0.0572 |
Echinococcus multilocularis | ectonucleotide | 0.0335 | 0.3238 | 0.3238 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0043 | 0.0127 | 0.0149 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0283 | 0.2681 | 0.6868 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0398 | 0.3904 | 0.4349 |
Mycobacterium leprae | Probable lipase LipE | 0.0043 | 0.0127 | 0.1529 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0043 | 0.0127 | 0.0149 |
Entamoeba histolytica | phosphatidylinositol-glycan biosynthesis class O protein, putative | 0.0063 | 0.0335 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0089 | 0.0621 | 0.0705 |
Schistosoma mansoni | hypothetical protein | 0.0858 | 0.8812 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0065 | 0.0356 | 0.0356 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0251 | 0.0643 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0035 | 0.0036 | 0.0041 |
Onchocerca volvulus | 0.0858 | 0.8812 | 1 | |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0398 | 0.3904 | 1 |
Brugia malayi | Thrombospondin type 1 domain containing protein | 0.0858 | 0.8812 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0251 | 0.0245 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0398 | 0.3904 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0251 | 0.0143 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0127 | 0.0144 |
Plasmodium falciparum | GPI ethanolamine phosphate transferase 3, putative | 0.0063 | 0.0335 | 0.5 |
Echinococcus granulosus | Endonuclease G | 0.0239 | 0.2213 | 0.5668 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0044 | 0.0139 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0335 | 0.3238 | 0.8294 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0063 | 0.0335 | 0.0335 |
Brugia malayi | hypothetical protein | 0.0063 | 0.0335 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0283 | 0.2681 | 0.3042 |
Mycobacterium tuberculosis | Conserved protein | 0.0043 | 0.0127 | 0.0149 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0044 | 0.0139 | 0.0057 |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.3904 | 0.443 |
Onchocerca volvulus | GPI ethanolamine phosphate transferase 2 homolog | 0.0063 | 0.0335 | 0.0239 |
Trypanosoma brucei | endonuclease G, putative | 0.0239 | 0.2213 | 1 |
Onchocerca volvulus | 0.0398 | 0.3904 | 0.4349 | |
Schistosoma mansoni | hypothetical protein | 0.0063 | 0.0335 | 0.0239 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0044 | 0.0139 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.0127 | 0.0127 |
Loa Loa (eye worm) | beta-lactamase | 0.0043 | 0.0127 | 0.0144 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0043 | 0.0127 | 0.0149 |
Schistosoma mansoni | lamin | 0.0065 | 0.0356 | 0.0263 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0283 | 0.2681 | 0.2681 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0398 | 0.3904 | 0.4349 |
Schistosoma mansoni | lamin | 0.0065 | 0.0356 | 0.0263 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.1727 | 0.1843 |
Echinococcus multilocularis | GPCR, family 2 | 0.0089 | 0.0621 | 0.0621 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0283 | 0.2681 | 0.3013 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0621 | 0.0705 |
Mycobacterium ulcerans | hypothetical protein | 0.0063 | 0.0335 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.012 | 0.0944 | 0.0941 |
Entamoeba histolytica | phosphatidylinositol-glycan biosynthesis class O protein, putative | 0.0063 | 0.0335 | 1 |
Echinococcus multilocularis | Endonuclease G | 0.0239 | 0.2213 | 0.2213 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0127 | 0.0144 |
Leishmania major | ethanolamine phosphotransferase, putative | 0.0063 | 0.0335 | 0.0995 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.0283 | 0.018 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0127 | 0.0103 |
Mycobacterium leprae | conserved hypothetical protein | 0.0043 | 0.0127 | 0.1529 |
Echinococcus granulosus | ectonucleotide | 0.0335 | 0.3238 | 0.8294 |
Trypanosoma brucei | GPI ethanolamine phosphate transferase 3, putative | 0.0063 | 0.0335 | 0.0995 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0089 | 0.0621 | 0.1592 |
Loa Loa (eye worm) | hypothetical protein | 0.0335 | 0.3238 | 0.3674 |
Echinococcus granulosus | lamin dm0 | 0.0065 | 0.0356 | 0.0911 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0283 | 0.2681 | 0.3013 |
Onchocerca volvulus | GPI ethanolamine phosphate transferase 3 homolog | 0.0063 | 0.0335 | 0.0239 |
Schistosoma mansoni | hypothetical protein | 0.0063 | 0.0335 | 0.0239 |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.0063 | 0.0335 | 0.034 |
Brugia malayi | AEL166Cp | 0.0063 | 0.0335 | 0.034 |
Schistosoma mansoni | hypothetical protein | 0.0089 | 0.0621 | 0.057 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0343 | 0.0389 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0089 | 0.0621 | 0.1592 |
Echinococcus granulosus | GPCR family 2 | 0.0089 | 0.0621 | 0.1592 |
Onchocerca volvulus | GPI ethanolamine phosphate transferase 1 homolog | 0.0063 | 0.0335 | 0.0239 |
Leishmania major | endonuclease G, putative | 0.0239 | 0.2213 | 1 |
Echinococcus multilocularis | Alkaline phosphatase, core domain | 0.0063 | 0.0335 | 0.0335 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0044 | 0.0139 | 0.0356 |
Trypanosoma brucei | endonuclease G, putative | 0.0239 | 0.2213 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0275 | 0.2599 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0043 | 0.0127 | 0.0127 |
Trypanosoma brucei | endonuclease G, putative | 0.0239 | 0.2213 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0065 | 0.0356 | 0.0403 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.