Detailed information for compound 1731654

Basic information

Technical information
  • TDR Targets ID: 1731654
  • Name: methyl (1R,2R,3S,3aR,8bS)-1-hydroxy-6,8,8b-tr imethoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3-di hydro-1H-cyclopenta[b][1]benzoxole-2-carboxyl ate
  • MW: 506.544 | Formula: C29H30O8
  • H donors: 1 H acceptors: 2 LogP: 3.75 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1)[C@]12Oc3c([C@]2(OC)[C@@H]([C@@H]([C@H]1c1ccccc1)C(=O)OC)O)c(OC)cc(c3)OC
  • InChi: 1S/C29H30O8/c1-32-19-13-11-18(12-14-19)28-24(17-9-7-6-8-10-17)23(27(31)35-4)26(30)29(28,36-5)25-21(34-3)15-20(33-2)16-22(25)37-28/h6-16,23-24,26,30H,1-5H3/t23-,24-,26-,28+,29+/m1/s1
  • InChiKey: OAKWLIZTUWAJDM-IDAMAFBJSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl (1R,2R,3S,3aR,8bS)-1-hydroxy-6,8,8b-trimethoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b]benzofuran-2-carboxylate
  • (1R,2R,3S,3aR,8bS)-1-hydroxy-6,8,8b-trimethoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b]benzofuran-2-carboxylic acid methyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0567 0.222
Entamoeba histolytica hypothetical protein 0.0033 0.0292 0.1248
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0033 0.0292 0.0292
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0064 0.0855 0.0855
Schistosoma mansoni hypothetical protein 0.0176 0.2889 0.2889
Entamoeba histolytica cysteine protease, putative 0.0027 0.0179 0.0713
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0028 0.0133
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0157 0.2544 0.2544
Loa Loa (eye worm) hypothetical protein 0.0027 0.0179 0.07
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.2139 1
Trypanosoma cruzi cysteine peptidase, putative 0.0135 0.2139 1
Trypanosoma cruzi UDP-galactopyranose mutase 0.003 0.0227 0.1062
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0037 0.0037
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0033 0.0292 0.1364
Mycobacterium tuberculosis Conserved protein 0.0037 0.037 0.0853
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.1944 0.7603
Loa Loa (eye worm) hypothetical protein 0.0033 0.0292 0.1141
Entamoeba histolytica cysteine protease, putative 0.0064 0.0855 0.3915
Brugia malayi Valyl-tRNA synthetase 0.0033 0.0292 0.1141
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.1381 0.5402
Onchocerca volvulus 0.0135 0.2139 0.8367
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0135 0.2139 1
Leishmania major UDP-galactopyranose mutase 0.003 0.0227 0.1062
Entamoeba histolytica cysteine proteinase 1, putative 0.0064 0.0855 0.3915
Schistosoma mansoni chromobox protein 0.0566 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0292 0.1248
Echinococcus granulosus geminin 0.0176 0.2889 0.2889
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0292 0.1248
Echinococcus multilocularis cathepsin L 0.0027 0.0179 0.0179
Entamoeba histolytica cysteine protease, putative 0.0064 0.0855 0.3915
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.003 0.0227 0.1062
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.037 0.037
Loa Loa (eye worm) hypothetical protein 0.003 0.0227 0.0889
Plasmodium vivax vivapain-2 0.0135 0.2139 1
Trichomonas vaginalis hypothetical protein 0.0033 0.0292 0.1248
Brugia malayi Papain family cysteine protease containing protein 0.0064 0.0855 0.3343
Plasmodium falciparum serine repeat antigen 2 0.0027 0.0179 0.0837
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0033 0.0292 0.1248
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0028 0.0111
Leishmania major DNA polymerase kappa, putative 0.0019 0.0037 0.0174
Plasmodium vivax heterochromatin protein 1, putative 0.0033 0.0292 0.1364
Schistosoma mansoni amine oxidase 0.003 0.0227 0.0227
Trypanosoma cruzi major cysteine proteinase, putative 0.0027 0.0179 0.0837
Trichomonas vaginalis chromobox protein, putative 0.0033 0.0292 0.1248
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0037 0.0037
Trichomonas vaginalis chromobox protein, putative 0.0033 0.0292 0.1248
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0027 0.0179 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0027 0.0179 0.07
Brugia malayi hypothetical protein 0.0025 0.0137 0.0535
Brugia malayi beta-lactamase 0.0037 0.037 0.1446
Echinococcus multilocularis Chromo domain 0.0033 0.0292 0.0292
Entamoeba histolytica hypothetical protein 0.0033 0.0292 0.1248
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0135 0.2139 1
Plasmodium vivax hypothetical protein, conserved 0.003 0.0227 0.1062
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0028 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0042
Schistosoma mansoni chromobox protein 0.0033 0.0292 0.0292
Loa Loa (eye worm) hypothetical protein 0.0033 0.0292 0.1141
Leishmania major cathepsin L-like protease 0.0135 0.2139 1
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0157 0.2544 0.2544
Echinococcus multilocularis cysteine protease 0.0135 0.2139 0.2139
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0027 0.0179 0.0713
Schistosoma mansoni cathepsin B (C01 family) 0.0027 0.0179 0.0179
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.2139 1
Echinococcus multilocularis chromobox protein 1 0.0033 0.0292 0.0292
Onchocerca volvulus 0.0033 0.0292 0.1141
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0027 0.0179 0.0713
Onchocerca volvulus 0.0043 0.0475 0.1858
Toxoplasma gondii ABC1 family protein 0.0037 0.037 0.1729
Onchocerca volvulus 0.0157 0.2556 1
Entamoeba histolytica cysteine proteinase, putative 0.0064 0.0855 0.3915
Plasmodium falciparum histone deacetylase 2 0.0041 0.0435 0.2034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0135 0.2139 1
Giardia lamblia Cathepsin B precursor 0.0027 0.0179 1
Brugia malayi Matrixin family protein 0.0104 0.1588 0.6211
Entamoeba histolytica cysteine protease, putative 0.0027 0.0179 0.0713
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.2139 1
Giardia lamblia Cathepsin B precursor 0.0027 0.0179 1
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0137 0.064
Entamoeba histolytica cysteine protease, putative 0.0064 0.0855 0.3915
Echinococcus multilocularis muscleblind protein 1 0.0148 0.2377 0.2377
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0179 0.0713
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0037 0.0366 0.1431
Leishmania major cathepsin L-like protease 0.0135 0.2139 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0366 0.1431
Onchocerca volvulus Matrilysin homolog 0.0043 0.0475 0.1858
Schistosoma mansoni cathepsin F (C01 family) 0.0097 0.1463 0.1463
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0758 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0033 0.0292 0.1248
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.037 0.1729
Giardia lamblia Cathepsin B precursor 0.0027 0.0179 1
Echinococcus multilocularis histone deacetylase 7 0.0041 0.0435 0.0435
Schistosoma mansoni ap endonuclease 0.0019 0.0028 0.0028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0179 0.0713
Giardia lamblia Cathepsin L precursor 0.0027 0.0179 1
Plasmodium falciparum serine repeat antigen 7 0.0027 0.0179 0.0837
Loa Loa (eye worm) hypothetical protein 0.0027 0.0179 0.07
Brugia malayi Cathepsin L-like precursor 0.0135 0.2139 0.8367
Echinococcus multilocularis 0.003 0.0227 0.0227
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.003 0.0227 0.1062
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0027 0.0179 0.0179
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0292 0.1248
Brugia malayi hypothetical protein 0.003 0.0227 0.0889
Trypanosoma cruzi cysteine peptidase, putative 0.0135 0.2139 1
Schistosoma mansoni histone deacetylase hda2 0.0041 0.0435 0.0435
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0027 0.0179 0.0837
Loa Loa (eye worm) hypothetical protein 0.0027 0.0179 0.07
Entamoeba histolytica cysteine proteinase, putative 0.0135 0.2139 1
Entamoeba histolytica cysteine protease, putative 0.0064 0.0855 0.3915
Echinococcus granulosus Chromo domain 0.0033 0.0292 0.0292
Schistosoma mansoni cathepsin S (C01 family) 0.0027 0.0179 0.0179
Loa Loa (eye worm) histone deacetylase 0.0041 0.0435 0.1702
Trypanosoma cruzi UDP-galactopyranose mutase 0.003 0.0227 0.1062
Echinococcus multilocularis histone deacetylase 6 0.0041 0.0435 0.0435
Plasmodium vivax hypothetical protein, conserved 0.003 0.0227 0.1062
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0758 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0292 0.1248
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0135 0.2139 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0137 0.064
Toxoplasma gondii cathepsin CPC2 0.0027 0.0179 0.0837
Loa Loa (eye worm) hypothetical protein 0.0037 0.037 0.1446
Loa Loa (eye worm) ctsf protein 0.0135 0.2139 0.8367
Brugia malayi Cathepsin L-like precursor 0.0037 0.0366 0.1431
Brugia malayi Matrixin family protein 0.0043 0.0475 0.1858
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0179 0.0713
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.037 0.1617
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0135 0.2139 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0037 0.0146
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0033 0.0292 0.1248
Chlamydia trachomatis protoporphyrinogen oxidase 0.003 0.0227 0.5
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0028 0.0133
Loa Loa (eye worm) hypothetical protein 0.0027 0.0179 0.07
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0027 0.0179 0.0713
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0027 0.0179 0.0837
Giardia lamblia Cathepsin L precursor 0.0027 0.0179 1
Mycobacterium ulcerans dehydrogenase 0.003 0.0227 0.2724
Loa Loa (eye worm) hypothetical protein 0.0037 0.037 0.1446
Echinococcus granulosus histone deacetylase 6 0.0041 0.0435 0.0435
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0027 0.0179 0.0179
Entamoeba histolytica hypothetical protein 0.0027 0.0179 0.0713
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0292 0.1248
Mycobacterium ulcerans monoamine oxidase 0.003 0.0227 0.2724
Entamoeba histolytica cysteine protease, putative 0.0064 0.0855 0.3915
Brugia malayi cathepsin Z-like cysteine proteinase 0.0027 0.0179 0.07
Echinococcus multilocularis dna polymerase eta 0.0019 0.0037 0.0037
Trichomonas vaginalis chromobox protein, putative 0.0033 0.0292 0.1248
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0037 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0042
Echinococcus granulosus cathepsin L 0.0027 0.0179 0.0179
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0027 0.0179 0.0713
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0064 0.0855 0.3996
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0292 0.1248
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0033 0.0292 0.1248
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0027 0.0179 0.0837
Brugia malayi Heterochromatin protein 1 0.0033 0.0292 0.1141
Giardia lamblia Cathepsin L precursor 0.0027 0.0179 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.037 0.4679
Plasmodium falciparum serine repeat antigen 3 0.0027 0.0179 0.0837
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.1381 0.5402
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0135 0.2139 0.2139
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0292 0.1248
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1381 0.1381
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0027 0.0179 0.0179
Loa Loa (eye worm) hypothetical protein 0.0019 0.0037 0.0146
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0042
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0292 0.1248
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0027 0.0179 1
Giardia lamblia Cathepsin B precursor 0.0027 0.0179 1
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0292 0.1248
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0027 0.0179 0.0179
Leishmania major cathepsin L-like protease 0.0135 0.2139 1
Entamoeba histolytica cysteine protease, putative 0.0064 0.0855 0.3915
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.003 0.0227 0.1062
Brugia malayi Cathepsin L-like precursor 0.0135 0.2139 0.8367
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.003 0.0227 0.0227
Mycobacterium ulcerans lipase LipD 0.0037 0.037 0.4679
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0027 0.0179 0.0837
Schistosoma mansoni histone deacetylase 4 5 0.0041 0.0435 0.0435
Plasmodium falciparum serine repeat antigen 8 0.0027 0.0179 0.0837
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0135 0.2139 0.8367
Entamoeba histolytica cysteine protease, putative 0.0064 0.0855 0.3915
Brugia malayi Cathepsin L-like precursor 0.0097 0.1463 0.5724
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.2139 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0135 0.2139 1
Giardia lamblia Cathepsin L precursor 0.0027 0.0179 1
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0033 0.0292 0.1364
Brugia malayi Matrixin family protein 0.0043 0.0475 0.1858
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0855 0.3915
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0135 0.2139 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0033 0.0292 0.1248
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.037 0.1617
Toxoplasma gondii exonuclease III APE 0.0019 0.0028 0.0133
Plasmodium vivax vivapain-2 0.0135 0.2139 1
Onchocerca volvulus 0.0135 0.2139 0.8367
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.1944 0.7603
Echinococcus granulosus chromobox protein 1 0.0033 0.0292 0.0292
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0033 0.0292 0.0292
Trichomonas vaginalis chromobox protein, putative 0.0033 0.0292 0.1248
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0033 0.0292 0.1248
Echinococcus multilocularis cathepsin L cysteine protease 0.0135 0.2139 0.2139
Loa Loa (eye worm) hypothetical protein 0.0148 0.2377 0.9297
Onchocerca volvulus Cathepsin F homolog 0.0135 0.2139 0.8367
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0028 0.5
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0027 0.0179 0.0837
Brugia malayi Protein cec-1. 0.0033 0.0292 0.1141
Entamoeba histolytica cysteine protease, putative 0.0064 0.0855 0.3915
Entamoeba histolytica cysteine protease, putative 0.0027 0.0179 0.0713
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0292 0.1248
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0027 0.0179 0.0713
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.003 0.0227 0.1062
Onchocerca volvulus Cathepsin L homolog 0.0135 0.2139 0.8367
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0135 0.2139 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0064 0.0855 0.3996
Plasmodium vivax vivapain-3 0.0064 0.0855 0.3996
Brugia malayi beta-lactamase family protein 0.0037 0.037 0.1446
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0027 0.0179 0.0179
Giardia lamblia Cathepsin B precursor 0.0027 0.0179 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.037 0.037
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0043 0.0475 0.0475
Echinococcus granulosus cathepsin l1 0.0135 0.2139 0.2139
Loa Loa (eye worm) matrix metalloproteinase 0.0043 0.0475 0.1858
Entamoeba histolytica cysteine protease, putative 0.0064 0.0855 0.3915
Echinococcus granulosus Chromobox protein 3 0.0033 0.0292 0.0292
Trypanosoma cruzi histone deacetylase, putative 0.0041 0.0435 0.2034
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0027 0.0179 0.0837
Loa Loa (eye worm) hypothetical protein 0.0033 0.0292 0.1141
Brugia malayi Cathepsin L-like precursor 0.0135 0.2139 0.8367
Onchocerca volvulus 0.0027 0.0179 0.07
Entamoeba histolytica cysteine protease, putative 0.0027 0.0179 0.0713
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.1381 0.1381
Echinococcus granulosus cathepsin L cysteine proteinase 0.0135 0.2139 0.2139
Onchocerca volvulus 0.0033 0.0292 0.1141
Giardia lamblia Cysteine protease 0.0027 0.0179 1
Loa Loa (eye worm) matrixin family protein 0.0104 0.1588 0.6211
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0064 0.0855 0.0855
Toxoplasma gondii preprocathepsin c precursor, putative 0.0027 0.0179 0.0837
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0292 0.1248
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0027 0.0179 0.0837
Loa Loa (eye worm) hypothetical protein 0.0049 0.059 0.2308
Brugia malayi Matrixin family protein 0.0043 0.0475 0.1858
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0033 0.0292 0.0292
Schistosoma mansoni cathepsin s 0.0037 0.0366 0.0366
Giardia lamblia Cathepsin B precursor 0.0027 0.0179 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0037 0.0037
Giardia lamblia Cathepsin B precursor 0.0027 0.0179 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.2377 0.9297
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0037 0.0022
Mycobacterium ulcerans oxidoreductase 0.003 0.0227 0.2724
Loa Loa (eye worm) hypothetical protein 0.0033 0.0292 0.1141
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.037 0.0853
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0027 0.0179 0.0179
Brugia malayi Papain family cysteine protease containing protein 0.0064 0.0855 0.3343
Brugia malayi Matrixin family protein 0.0043 0.0475 0.1858
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0027 0.0179 0.0179
Mycobacterium ulcerans hydrolase 0.0053 0.0646 0.8465
Trypanosoma cruzi histone deacetylase, putative 0.0041 0.0435 0.2034
Loa Loa (eye worm) hypothetical protein 0.0135 0.2139 0.8367
Leishmania major hypothetical protein, conserved 0.0025 0.0137 0.064
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0027 0.0179 0.0837
Brugia malayi CHD4 protein 0.0033 0.0292 0.1141
Loa Loa (eye worm) hypothetical protein 0.0033 0.0292 0.1141
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0137 0.064
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0027 0.0179 0.0179
Echinococcus multilocularis cathepsin b 0.0027 0.0179 0.0179
Mycobacterium leprae Probable lipase LipE 0.0037 0.037 0.3405
Brugia malayi Cytochrome P450 family protein 0.0048 0.0567 0.222
Loa Loa (eye worm) hypothetical protein 0.0037 0.037 0.1446
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0292 0.1248
Echinococcus granulosus cathepsin l1 0.0097 0.1463 0.1463
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0033 0.0292 0.1364
Toxoplasma gondii cathepsin CPL 0.0135 0.2139 1
Giardia lamblia Cathepsin L-like protease 0.0027 0.0179 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0042
Loa Loa (eye worm) hypothetical protein 0.0037 0.037 0.1446
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0135 0.2139 1
Entamoeba histolytica cysteine proteinase, putative 0.0135 0.2139 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0037 0.0042
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0027 0.0179 0.0837
Leishmania major histone deacetylase, putative 0.0041 0.0435 0.2034
Echinococcus multilocularis histone deacetylase 6 0.0041 0.0435 0.0435
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0135 0.2139 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.1381 0.1381
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0758 0.3544
Loa Loa (eye worm) heterochromatin protein 1 0.0033 0.0292 0.1141
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0135 0.2139 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.0039 0.0141
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0028 0.0133
Loa Loa (eye worm) hypothetical protein 0.0097 0.1463 0.5724
Toxoplasma gondii cathepsin CPC1 0.0027 0.0179 0.0837
Brugia malayi Cathepsin L-like precursor 0.0135 0.2139 0.8367
Echinococcus granulosus cathepsin L cysteine protease 0.0064 0.0855 0.0855
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0027 0.0179 0.0713
Echinococcus granulosus histone deacetylase 6 0.0041 0.0435 0.0435
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0292 0.1248
Leishmania major cathepsin L-like protease 0.0135 0.2139 1
Brugia malayi Histone deacetylase family protein 0.0041 0.0435 0.1702
Brugia malayi Cathepsin L-like precursor 0.0135 0.2139 0.8367
Echinococcus multilocularis histone deacetylase 6 0.0041 0.0435 0.0435
Giardia lamblia Cathepsin L-like protease 0.0027 0.0179 1
Plasmodium falciparum serine repeat antigen 9 0.0027 0.0179 0.0837
Loa Loa (eye worm) hypothetical protein 0.0043 0.0475 0.1858
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0027 0.0179 0.0837
Echinococcus granulosus lysine specific histone demethylase 1A 0.003 0.0227 0.0227
Schistosoma mansoni hypothetical protein 0.0176 0.2889 0.2889
Loa Loa (eye worm) helicase 0.0033 0.0292 0.1141
Onchocerca volvulus 0.0061 0.0803 0.3141
Schistosoma mansoni ap endonuclease 0.0019 0.0028 0.0028
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.037 0.1617
Echinococcus granulosus dna polymerase eta 0.0019 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.003 0.0227 0.0889
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0135 0.2139 1
Onchocerca volvulus 0.0097 0.1463 0.5724
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0137 0.0514
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0042
Brugia malayi hypothetical protein 0.0033 0.0292 0.1141
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0758 0.0758
Brugia malayi SWIRM domain containing protein 0.0157 0.2556 1
Echinococcus multilocularis Chromobox protein 3 0.0033 0.0292 0.0292
Trichomonas vaginalis chromobox protein, putative 0.0033 0.0292 0.1248
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0037 0.0174
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0135 0.2139 1
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0292 0.1248
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.2139 1
Onchocerca volvulus 0.0135 0.2139 0.8367
Schistosoma mansoni cathepsin F (C01 family) 0.0135 0.2139 0.2139
Entamoeba histolytica cysteine proteinase, putative 0.0064 0.0855 0.3915
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0027 0.0179 0.0837
Plasmodium falciparum serine repeat antigen 1 0.0027 0.0179 0.0837
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0033 0.0292 0.1141
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0028 0.0111
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0033 0.0292 0.1141
Echinococcus multilocularis geminin 0.0176 0.2889 0.2889
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0027 0.0179 0.0713
Loa Loa (eye worm) hypothetical protein 0.0037 0.037 0.1446
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0305 0.1194
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.037 0.0853
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0033 0.0292 0.0292
Mycobacterium ulcerans hypothetical protein 0.0037 0.037 0.4679
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.0179 0.07
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0027 0.0179 0.0179
Brugia malayi amine oxidase, flavin-containing family protein 0.0042 0.0451 0.1763
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0135 0.2139 0.2139
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.0179 0.07
Leishmania major hypothetical protein, conserved 0.0037 0.037 0.1729
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0179 0.0713
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.037 0.1446
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0037 0.0174
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0135 0.2139 1
Onchocerca volvulus 0.0037 0.037 0.1446
Brugia malayi Cathepsin L-like precursor 0.0097 0.1463 0.5724
Loa Loa (eye worm) hypothetical protein 0.0043 0.0475 0.1858
Brugia malayi SET domain containing protein 0.0033 0.0292 0.1141
Echinococcus multilocularis protoporphyrinogen oxidase 0.003 0.0227 0.0227
Giardia lamblia Cysteine protease 0.0027 0.0179 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0097 0.1463 0.6841
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0145 0.2333 0.2333
Trypanosoma cruzi major cysteine proteinase, putative 0.0027 0.0179 0.0837
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0037 0.0037
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0758 0.3544
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.0179 0.07
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0064 0.0855 0.0855
Leishmania major cytochrome p450-like protein 0.0019 0.0039 0.0181
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.037 0.0853
Echinococcus granulosus chromobox protein 1 0.0033 0.0292 0.0292
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0042
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.037 0.037
Trypanosoma cruzi cysteine proteinase, putative 0.0064 0.0855 0.3996
Loa Loa (eye worm) cysteine protease 0.0135 0.2139 0.8367
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0179 0.0713
Plasmodium falciparum serine repeat antigen 6 0.0027 0.0179 0.0837
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0097 0.1463 0.6799
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0039 0.0151
Loa Loa (eye worm) CHromoDomain protein family member 0.0033 0.0292 0.1141
Entamoeba histolytica cysteine proteinase, putative 0.0064 0.0855 0.3915
Mycobacterium leprae PROBABLE HYDROLASE 0.0053 0.0646 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0758 0.0758
Brugia malayi MH2 domain containing protein 0.0124 0.1944 0.7603
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0292 0.1248
Echinococcus granulosus histone deacetylase 7 0.0041 0.0435 0.0435
Loa Loa (eye worm) beta-lactamase 0.0037 0.037 0.1446
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0037 0.0146
Loa Loa (eye worm) hypothetical protein 0.0145 0.2333 0.9126
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0855 0.3915
Echinococcus granulosus histone deacetylase 6 0.0041 0.0435 0.0435
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0027 0.0179 0.0837
Brugia malayi chromobox protein homolog 3 0.0033 0.0292 0.1141
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0027 0.0179 0.0179
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0033 0.0292 0.0292
Trypanosoma brucei histone deacetylase 4 0.0041 0.0435 0.1926
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0037 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.2139 1
Plasmodium falciparum serine repeat antigen 4 0.0027 0.0179 0.0837
Entamoeba histolytica cysteine proteinase, putative 0.0064 0.0855 0.3915
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0033 0.0292 0.1248
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.1381 0.1381
Loa Loa (eye worm) hypothetical protein 0.0037 0.0366 0.1431
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0179 0.0713
Loa Loa (eye worm) hypothetical protein 0.0041 0.0435 0.1702
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0855 0.3996
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.059 0.2308
Entamoeba histolytica cysteine proteinase 2 0.0064 0.0855 0.3915
Trypanosoma cruzi cruzipain precursor, putative 0.0037 0.0366 0.171
Onchocerca volvulus 0.0135 0.2139 0.8367
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0027 0.0179 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0135 0.2139 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0292 0.1141
Echinococcus multilocularis cysteine protease 0.0135 0.2139 0.2139
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.059 0.2308
Entamoeba histolytica cysteine protease, putative 0.0027 0.0179 0.0713
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0292 0.1248
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0037 0.0174
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0135 0.2139 1
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.037 0.0853
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0033 0.0292 0.0292
Loa Loa (eye worm) cathepsin B 0.0027 0.0179 0.07
Echinococcus granulosus lysine specific histone demethylase 1A 0.0145 0.2333 0.2333
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0039 0.0151
Plasmodium vivax unspecified product 0.0037 0.0366 0.171
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0037 0.0146
Schistosoma mansoni cathepsin C 0.0027 0.0179 0.0179
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0135 0.2139 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0042
Echinococcus granulosus dna polymerase kappa 0.0019 0.0037 0.0037
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0037 0.0042
Trypanosoma cruzi cysteine peptidase, putative 0.0135 0.2139 1
Entamoeba histolytica cysteine protease, putative 0.0027 0.0179 0.0713
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0027 0.0179 0.0837
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0292 0.0292
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0855 0.3915
Loa Loa (eye worm) hypothetical protein 0.0042 0.0451 0.1763
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0037 0.0121
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0179 0.0713
Toxoplasma gondii histone deacetylase HDAC1 0.0041 0.0435 0.2034
Loa Loa (eye worm) hypothetical protein 0.0034 0.0305 0.1194
Loa Loa (eye worm) hypothetical protein 0.0037 0.0366 0.1431
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0039 0.0181
Plasmodium vivax histone deacetylase, putative 0.0041 0.0435 0.2034
Brugia malayi cathepsin F-like cysteine proteinase 0.0027 0.0179 0.07
Entamoeba histolytica cysteine protease, putative 0.0064 0.0855 0.3915
Onchocerca volvulus Cathepsin L homolog 0.0027 0.0179 0.07
Plasmodium falciparum heterochromatin protein 1 0.0033 0.0292 0.1364
Leishmania major cathepsin L-like protease 0.0135 0.2139 1
Trypanosoma cruzi cysteine peptidase, putative 0.0135 0.2139 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.1463 0.5724
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0758 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.003 0.0227 0.0496
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0137 0.064
Echinococcus granulosus cathepsin L 0.0064 0.0855 0.0855
Giardia lamblia Hypothetical protein 0.0027 0.0179 1
Schistosoma mansoni DNA polymerase eta 0.0019 0.0037 0.0037
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0027 0.0179 0.07
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0855 0.3915
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.2139 1
Echinococcus granulosus histone deacetylase 0.0041 0.0435 0.0435
Plasmodium falciparum protoporphyrinogen oxidase 0.003 0.0227 0.1062
Trypanosoma brucei unspecified product 0.0019 0.0037 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0292 0.1248
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.037 0.4679
Loa Loa (eye worm) hypothetical protein 0.0037 0.037 0.1446
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0292 0.1364
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1381 0.1381
Loa Loa (eye worm) hypothetical protein 0.0027 0.0179 0.07
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0039 0.0181
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0027 0.0179 0.0713
Schistosoma mansoni amine oxidase 0.003 0.0227 0.0227
Echinococcus multilocularis cathepsin L 0.0064 0.0855 0.0855
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0239 0.4032 1
Echinococcus granulosus cysteine protease 0.0064 0.0855 0.0855
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0037 0.0037
Brugia malayi cathepsin B-like cysteine proteinase 0.0027 0.0179 0.07
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0135 0.2139 1
Trichomonas vaginalis chromobox protein, putative 0.0033 0.0292 0.1248
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.037 0.0853
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.037 0.1617
Brugia malayi cathepsin Z-like cysteine proteinase 0.0027 0.0179 0.07
Schistosoma mansoni hypothetical protein 0.0061 0.0803 0.0803
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0135 0.2139 1
Echinococcus granulosus muscleblind protein 0.0148 0.2377 0.2377
Trypanosoma cruzi cruzipain precursor, putative 0.0135 0.2139 1
Onchocerca volvulus 0.0037 0.037 0.1446
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0135 0.2139 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0037 0.0042
Leishmania major cathepsin L-like protease 0.0135 0.2139 1
Entamoeba histolytica cysteine protease, putative 0.0064 0.0855 0.3915
Loa Loa (eye worm) hypothetical protein 0.0053 0.0646 0.2527
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0039 0.0151
Echinococcus granulosus cathepsin b 0.0027 0.0179 0.0179
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0027 0.0179 0.0837
Toxoplasma gondii cathepsin B 0.0027 0.0179 0.0837
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0053 0.0646 0.2527
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0135 0.2139 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0758 0.1822
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0135 0.2139 1
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0053 0.0646 0.1543
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0292 0.1248
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0027 0.0179 1
Plasmodium falciparum histone deacetylase, putative 0.0041 0.0435 0.2034
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0037 0.0174
Schistosoma mansoni cathepsin F (C01 family) 0.0135 0.2139 0.2139
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0179 0.0713
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0027 0.0179 0.0713
Loa Loa (eye worm) hypothetical protein 0.0025 0.0137 0.0535
Onchocerca volvulus Cathepsin L homolog 0.0135 0.2139 0.8367
Brugia malayi Cytochrome P450 family protein 0.0019 0.0039 0.0151
Loa Loa (eye worm) hypothetical protein 0.0041 0.0435 0.1702
Mycobacterium tuberculosis Conserved protein 0.0037 0.037 0.0853
Plasmodium vivax serine-repeat antigen (SERA) 0.0027 0.0179 0.0837
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0027 0.0179 0.0179
Trypanosoma cruzi cysteine proteinase, putative 0.0064 0.0855 0.3996
Giardia lamblia Cathepsin L precursor 0.0027 0.0179 1
Loa Loa (eye worm) hypothetical protein 0.0145 0.2333 0.9126
Brugia malayi Hemopexin family protein 0.0061 0.0803 0.3141
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0135 0.2139 1
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0039 0.0049
Trypanosoma brucei histone deacetylase 3 0.0041 0.0435 0.1926
Brugia malayi cathepsin L precursor 0.0027 0.0179 0.07
Giardia lamblia Cysteine protease 0.0027 0.0179 1
Loa Loa (eye worm) histone deacetylase 7A 0.0041 0.0435 0.1702
Brugia malayi Cathepsin L-like cysteine proteinase 0.0097 0.1463 0.5724
Plasmodium vivax histone deacetylase 2, putative 0.0041 0.0435 0.2034
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0028 0.0133
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0135 0.2139 0.8367
Brugia malayi beta-lactamase family protein 0.0037 0.037 0.1446
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0033 0.0292 0.1364
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0027 0.0179 0.0713
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0027 0.0179 0.0837
Plasmodium falciparum serine repeat antigen 5 0.0027 0.0179 0.0837
Loa Loa (eye worm) matrixin family protein 0.0096 0.1431 0.5597
Entamoeba histolytica cysteine protease, putative 0.0064 0.0855 0.3915
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0145 0.2333 0.2333
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.2139 1
Loa Loa (eye worm) fibroinase 0.0135 0.2139 0.8367
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.037 0.0853
Toxoplasma gondii histone lysine-specific demethylase 0.003 0.0227 0.1062
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0027 0.0179 0.0837
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0027 0.0179 0.0179
Brugia malayi cathepsin F-like cysteine proteinase 0.0037 0.0366 0.1431
Onchocerca volvulus 0.0037 0.037 0.1446
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0042
Mycobacterium leprae conserved hypothetical protein 0.0037 0.037 0.3405
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.037 0.037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0179 0.0713
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0037 0.0121
Onchocerca volvulus 0.0033 0.0292 0.1141
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0135 0.2139 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0179 0.0713
Giardia lamblia Cathepsin B precursor 0.0027 0.0179 1
Schistosoma mansoni chromobox protein 0.0033 0.0292 0.0292
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0037 0.0042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0097 0.1463 0.6799
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.037 0.1446
Echinococcus multilocularis cathepsin b 0.0027 0.0179 0.0179
Brugia malayi fibroinase precursor 0.0027 0.0179 0.07
Leishmania major cysteine peptidase A (CPA) 0.0135 0.2139 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2556 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0037 0.0042
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0137 0.064
Onchocerca volvulus Matrix metalloproteinase homolog 0.0096 0.1431 0.5597
Brugia malayi Histone deacetylase family protein 0.0041 0.0435 0.1702
Plasmodium vivax unspecified product 0.0064 0.0855 0.3996
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0037 0.0042
Onchocerca volvulus 0.0135 0.2139 0.8367
Brugia malayi Cytochrome P450 family protein 0.0019 0.0039 0.0151
Leishmania major cathepsin L-like protease 0.0135 0.2139 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0027 0.0179 0.0179
Echinococcus multilocularis chromobox protein 1 0.0033 0.0292 0.0292
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0027 0.0179 0.0179
Plasmodium vivax unspecified product 0.0027 0.0179 0.0837
Trichomonas vaginalis chromobox protein, putative 0.0033 0.0292 0.1248
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.037 0.1729
Giardia lamblia Encystation-specific protease 0.0027 0.0179 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1381 0.1381
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0028 0.0028
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0027 0.0179 0.0713
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0027 0.0179 0.07
Brugia malayi Associated with TFs and helicases family protein 0.0033 0.0292 0.1141
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0037 0.0174
Entamoeba histolytica cysteine protease, putative 0.0064 0.0855 0.3915
Loa Loa (eye worm) hypothetical protein 0.0033 0.0292 0.1141
Loa Loa (eye worm) hypothetical protein 0.0043 0.0475 0.1858
Brugia malayi Muscleblind-like protein 0.0148 0.2377 0.9297
Schistosoma mansoni chromobox protein 0.0033 0.0292 0.0292
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.2139 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0135 0.2139 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0292 0.1141
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0028 0.0133
Trichomonas vaginalis Heterochromatin protein, putative 0.0033 0.0292 0.1248
Trypanosoma brucei histone deacetylase, putative 0.0041 0.0435 0.1926
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.003 0.0227 0.2724
Leishmania major histone deacetylase, putative 0.0041 0.0435 0.2034
Trypanosoma brucei cysteine peptidase C (CPC) 0.0027 0.0179 0.0713
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0033 0.0292 0.1248
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0135 0.2139 1
Trypanosoma cruzi histone deacetylase, putative 0.0041 0.0435 0.2034
Plasmodium vivax hypothetical protein, conserved 0.0037 0.037 0.1729
Leishmania major DNA polymerase eta, putative 0.0019 0.0037 0.0174
Leishmania major cathepsin L-like protease 0.0135 0.2139 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.2139 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0042
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0137 0.064
Plasmodium vivax protoporphyrinogen oxidase, putative 0.003 0.0227 0.1062
Echinococcus multilocularis chromobox protein 2 0.0566 1 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0028 0.0028
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0758 0.0758
Giardia lamblia Hypothetical protein 0.0027 0.0179 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0027 0.0179 0.0837
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0033 0.0292 0.0292
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0037 0.0366 0.1431
Onchocerca volvulus Matrilysin homolog 0.0096 0.1431 0.5597
Echinococcus granulosus cathepsin b 0.0027 0.0179 0.0179
Giardia lamblia Cysteine protease 0.0027 0.0179 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.059 0.2308
Trypanosoma cruzi cysteine protease, putative 0.0064 0.0855 0.3996
Trypanosoma cruzi cysteine peptidase, putative 0.0037 0.0366 0.171
Giardia lamblia DINP protein human, muc B family 0.0019 0.0037 0.0588
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0033 0.0292 0.0292
Echinococcus multilocularis muscleblind protein 0.0148 0.2377 0.2377
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.037 0.1617
Plasmodium vivax vivapain-1 0.0064 0.0855 0.3996
Brugia malayi cathepsin L-like cysteine proteinase 0.0027 0.0179 0.07
Schistosoma mansoni hypothetical protein 0.0034 0.0305 0.0305
Giardia lamblia Cathepsin L precursor 0.0027 0.0179 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0135 0.2139 1
Brugia malayi Cathepsin L-like precursor 0.0135 0.2139 0.8367
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.003 0.0227 0.2724
Loa Loa (eye worm) hypothetical protein 0.0027 0.0179 0.07
Entamoeba histolytica cysteine proteinase, putative 0.0097 0.1463 0.6799
Brugia malayi cathepsin L-like precursor 0.0097 0.1463 0.5724
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0179 0.0713
Entamoeba histolytica cysteine protease, putative 0.0135 0.2139 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0042
Brugia malayi M-phase phosphoprotein, mpp8 0.0033 0.0292 0.1141
Schistosoma mansoni hypothetical protein 0.0033 0.0292 0.0292
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0292 0.1364
Loa Loa (eye worm) hypothetical protein 0.0027 0.0179 0.07
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.037 0.1617
Echinococcus multilocularis cathepsin L cysteine protease 0.0135 0.2139 0.2139
Trichomonas vaginalis esterase, putative 0.0037 0.037 0.1617
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0758 0.0758
Entamoeba histolytica hypothetical protein 0.0033 0.0292 0.1248
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0033 0.0292 0.1364
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.037 0.0853
Echinococcus granulosus cathepsin l cysteine peptidase 0.0135 0.2139 0.2139
Mycobacterium ulcerans beta-lactamase 0.0037 0.037 0.4679
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0292 0.1248
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.1381 0.1381
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.2139 1
Mycobacterium ulcerans protoporphyrinogen oxidase 0.003 0.0227 0.2724
Echinococcus multilocularis histone deacetylase 0.0041 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.0097 0.1463 0.5724
Brugia malayi Papain family cysteine protease containing protein 0.0135 0.2139 0.8367
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0135 0.2139 1
Mycobacterium tuberculosis Conserved protein 0.0037 0.037 0.0853
Mycobacterium tuberculosis Possible oxidoreductase 0.003 0.0227 0.0496
Schistosoma mansoni histone deacetylase 4 5 0.0041 0.0435 0.0435
Onchocerca volvulus 0.0135 0.2139 0.8367
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0033 0.0292 0.1141
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0037 0.0174
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0027 0.0179 0.07
Onchocerca volvulus 0.0135 0.2139 0.8367

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 4.9 uM Cytotoxicity against human HT-29 cells ChEMBL. 23301897
ED50 (binding) > 20 uM Inhibition of NF-kappaB p65 (unknown origin) by ELISA ChEMBL. 23301897

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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