Detailed information for compound 1743680

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 496.921 | Formula: C20H21ClN4O7S
  • H donors: 5 H acceptors: 7 LogP: 0.67 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CNC(=O)c1ccc(cc1)S(=O)(=O)N)NCC(=O)N[C@H](C(=O)O)Cc1ccc(cc1)Cl
  • InChi: 1S/C20H21ClN4O7S/c21-14-5-1-12(2-6-14)9-16(20(29)30)25-18(27)11-23-17(26)10-24-19(28)13-3-7-15(8-4-13)33(22,31)32/h1-8,16H,9-11H2,(H,23,26)(H,24,28)(H,25,27)(H,29,30)(H2,22,31,32)/t16-/m0/s1
  • InChiKey: HTDSXHKTRHYFMS-INIZCTEOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens carbonic anhydrase II Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania infantum carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma cruzi carbonic anhydrase-like protein, putative Get druggable targets OG5_127628 All targets in OG5_127628
Echinococcus granulosus carbonic anhydrase II Get druggable targets OG5_127628 All targets in OG5_127628
Brugia malayi Putative carbonic anhydrase 5 precursor Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma japonicum ko:K01672 carbonic anhydrase [EC4.2.1.1], putative Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma congolense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania mexicana carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Loa Loa (eye worm) carbonic anhydrase 3 Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma congolense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma cruzi carbonic anhydrase-like protein, putative Get druggable targets OG5_127628 All targets in OG5_127628
Brugia malayi Eukaryotic-type carbonic anhydrase family protein Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania donovani carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma brucei carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Echinococcus multilocularis carbonic anhydrase II Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania braziliensis carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma brucei gambiense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Carbonic anhydrase like protein 2 precursor carbonic anhydrase II 260 aa 259 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni alpha glucosidase 0.0036 0.0071 0.0068
Echinococcus granulosus geminin 0.0179 0.0529 0.0529
Schistosoma mansoni hypothetical protein 0.0687 0.2154 0.2152
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.019 0.0564 0.0862
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0058 0.0058
Schistosoma mansoni voltage-gated potassium channel 0.019 0.0564 0.0562
Schistosoma mansoni voltage-gated potassium channel 0.019 0.0564 0.0562
Echinococcus multilocularis muscleblind protein 0.0307 0.0938 0.0938
Echinococcus granulosus thyroid hormone receptor alpha 0.0015 0.0004 0.0004
Echinococcus granulosus tyrosine protein kinase HCK 0.0035 0.0069 0.0069
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0142 0.0139
Echinococcus granulosus potassium voltage gated channel subfamily D 0.019 0.0564 0.0564
Loa Loa (eye worm) hypothetical protein 0.0083 0.0221 0.0221
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0004 0.0001
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0778 0.9363
Echinococcus granulosus N chimaerin 0.0016 0.0007 0.0007
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.019 0.0564 1
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.019 0.0564 0.0562
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.019 0.0564 0.0562
Echinococcus multilocularis GPCR, family 2 0.0018 0.0015 0.0015
Echinococcus granulosus tyrosine protein kinase Src42A 0.0039 0.0082 0.0082
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0015 0.0003 0.0003
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0247 0.0745 0.0743
Brugia malayi Cyclic-nucleotide gated cation channel 0.019 0.0564 0.0562
Echinococcus granulosus two pore calcium channel protein 1 0.019 0.0564 0.0564
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0058 0.0055
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.019 0.0564 0.0562
Toxoplasma gondii transporter, cation channel family protein 0.019 0.0564 1
Onchocerca volvulus Deterin homolog 0.2049 0.6507 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0071 0.0068
Loa Loa (eye worm) glutaminase 0.0272 0.0826 0.0826
Onchocerca volvulus 0.019 0.0564 0.0862
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.0053
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.019 0.0564 0.0562
Brugia malayi nuclear hormone receptor 0.0015 0.0004 0.0001
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.2049 0.6507 0.6507
Loa Loa (eye worm) hypothetical protein 0.0028 0.0045 0.0045
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0058 0.0058
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0053 0.0053
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0197 0.0587 0.0587
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0018 0.0013 0.0013
Loa Loa (eye worm) ryanodine receptor 0.019 0.0564 0.0564
Schistosoma mansoni carbonic anhydrase-related 0.0034 0.0063 0.006
Echinococcus multilocularis calcium activated potassium channel 0.019 0.0564 0.0564
Toxoplasma gondii transporter, cation channel family protein 0.019 0.0564 1
Schistosoma mansoni hypothetical protein 0.0018 0.0015 0.0012
Echinococcus granulosus cyclic nucleotide gated cation channel 0.019 0.0564 0.0564
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.019 0.0564 0.0564
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.019 0.0564 0.0562
Loa Loa (eye worm) carbonic anhydrase 3 0.0147 0.0427 0.0427
Schistosoma mansoni zinc finger protein 0.0015 0.0004 0.0001
Schistosoma mansoni voltage-dependent calcium channel 0.019 0.0564 0.0562
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0151 0.225
Schistosoma mansoni alpha-glucosidase 0.014 0.0402 0.04
Onchocerca volvulus 0.0687 0.2154 0.3306
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0015 0.0012
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0058 0.0058
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.019 0.0564 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.005 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0032 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.004 0.0083 0.0083
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.3141 1 1
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0018 0.0013 0.0013
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0336 0.0336
Echinococcus multilocularis two pore calcium channel protein 1 0.019 0.0564 0.0564
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0147 0.0427 0.0424
Schistosoma mansoni lamin 0.0029 0.0047 0.0044
Schistosoma mansoni 60S ribosomal protein L21 0.019 0.0564 0.0562
Echinococcus multilocularis tyrosine protein kinase Abl 0.0104 0.0289 0.0289
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0166 0.0163
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0004
Echinococcus multilocularis transfer RNA-Gly 0.019 0.0564 0.0564
Echinococcus multilocularis tyrosine protein kinase Blk 0.0043 0.0092 0.0092
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0058 0.0055
Loa Loa (eye worm) hypothetical protein 0.0032 0.0058 0.0058
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0071 0.0071
Schistosoma mansoni voltage-gated potassium channel 0.019 0.0564 0.0562
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.019 0.0564 0.0862
Schistosoma mansoni vav2 0.0016 0.0007 0.0004
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0149 0.0146
Echinococcus multilocularis N chimaerin 0.0016 0.0007 0.0007
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0149 0.1662
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0149 0.1494
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0524 0.6004
Brugia malayi Variant SH3 domain containing protein 0.0016 0.0007 0.0004
Brugia malayi nuclear hormone receptor family member nhr-6 0.0015 0.0004 0.0001
Onchocerca volvulus 0.0083 0.0221 0.0333
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0111 0.0111
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.001 0.0007
Onchocerca volvulus 0.0203 0.0604 0.0923
Brugia malayi Matrixin family protein 0.0203 0.0604 0.0601
Echinococcus multilocularis hyperpolarization activated cyclic 0.019 0.0564 0.0564
Echinococcus granulosus NCK adaptor protein 0.0015 0.0003 0.0003
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0004 0.0004
Echinococcus granulosus potassium voltage gated channel protein 0.019 0.0564 0.0564
Echinococcus granulosus tyrosine protein kinase Fyn 0.005 0.0115 0.0115
Trypanosoma brucei carbonic anhydrase-like protein 0.0147 0.0427 0.7421
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0111 0.0108
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.001
Brugia malayi cation channel family protein 0.019 0.0564 0.0562
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0039 0.0082 0.0082
Echinococcus multilocularis thyroid hormone receptor alpha 0.0032 0.0058 0.0058
Echinococcus granulosus short transient receptor potential channel 6 0.019 0.0564 0.0564
Echinococcus granulosus potassium voltage gated channel protein 0.019 0.0564 0.0564
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.003 0.5
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0004
Schistosoma mansoni inhibitor of apoptosis protein 0.2049 0.6507 0.6506
Echinococcus multilocularis microtubule associated protein 2 0.1418 0.4491 0.4491
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0111 0.0111
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0015 0.0004 0.0004
Schistosoma mansoni carbonic anhydrase-related 0.0034 0.0063 0.006
Echinococcus granulosus transient receptor potential cation channel 0.019 0.0564 0.0564
Echinococcus granulosus shaker cognate 0.019 0.0564 0.0564
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.019 0.0564 0.0564
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0047 0.0047
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0147 0.0427 0.0424
Onchocerca volvulus 0.0029 0.0047 0.0066
Brugia malayi voltage-dependent calcium channel 0.019 0.0564 0.0562
Echinococcus multilocularis tyrosine protein kinase Src42A 0.005 0.0115 0.0115
Echinococcus granulosus potassium voltage gated channel subfamily D 0.019 0.0564 0.0564
Loa Loa (eye worm) hypothetical protein 0.019 0.0564 0.0564
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0147 0.0427 0.7209
Brugia malayi Pre-SET motif family protein 0.003 0.0053 0.005
Echinococcus granulosus lysosomal alpha glucosidase 0.0162 0.0474 0.0474
Echinococcus multilocularis voltage gated potassium channel 0.019 0.0564 0.0564
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.019 0.0564 0.0564
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0047 0.0047
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.019 0.0564 0.0562
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0005 0.0005
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0058 0.0055
Echinococcus multilocularis tar DNA binding protein 0.0067 0.017 0.017
Echinococcus multilocularis lamin dm0 0.0029 0.0047 0.0047
Loa Loa (eye worm) DR-78 0.0015 0.0004 0.0004
Leishmania major calcium channel protein, putative,ion transporter, putative 0.019 0.0564 1
Schistosoma mansoni voltage-gated potassium channel 0.019 0.0564 0.0562
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.005 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.019 0.0564 0.0564
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0167 0.0491 0.0489
Brugia malayi protein-tyrosine kinase 0.0043 0.0092 0.0089
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.019 0.0564 0.0564
Echinococcus multilocularis potassium voltage gated channel protein 0.019 0.0564 0.0564
Echinococcus multilocularis sodium channel protein 0.019 0.0564 0.0564
Loa Loa (eye worm) hypothetical protein 0.0034 0.0063 0.0063
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.019 0.0564 0.0562
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0078 0.0078
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.014 0.0404 0.0404
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0111 0.0111
Echinococcus granulosus intermediate filament protein 0.0029 0.0047 0.0047
Echinococcus multilocularis tyrosine protein kinase Fyn 0.005 0.0115 0.0115
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0034 0.0063 0.006
Loa Loa (eye worm) hypothetical protein 0.0247 0.0745 0.0745
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0004 0.0004
Brugia malayi hypothetical protein 0.0015 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0034 0.0063 0.006
Toxoplasma gondii transporter, cation channel family protein 0.019 0.0564 1
Loa Loa (eye worm) hypothetical protein 0.0307 0.0938 0.0938
Schistosoma mansoni caspase-7 (C14 family) 0.0687 0.2154 0.2152
Echinococcus granulosus transient receptor potential gamma protein 0.019 0.0564 0.0564
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0142 0.0142
Echinococcus granulosus potassium voltage gated channel subfamily D 0.019 0.0564 0.0564
Brugia malayi Cell death protein 3 precursor 0.0687 0.2154 0.2152
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0203 0.0604 0.0604
Echinococcus multilocularis potassium voltage gated channel protein 0.019 0.0564 0.0564
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.019 0.0564 0.0564
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0149 0.0149
Loa Loa (eye worm) SRC-1 0.005 0.0115 0.0115
Schistosoma mansoni voltage-gated potassium channel 0.019 0.0564 0.0562
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0237 0.0714 0.0712
Echinococcus granulosus carbonic anhydrase 0.0034 0.0063 0.0063
Brugia malayi ion channel NompC 0.019 0.0564 0.0562
Schistosoma mansoni voltage-gated potassium channel 0.019 0.0564 0.0562
Echinococcus multilocularis hyperpolarization activated cyclic 0.019 0.0564 0.0564
Brugia malayi Transient-receptor-potential like protein 0.019 0.0564 0.0562
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0053 0.0427
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0034 0.0063 0.006
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0495 0.5619
Echinococcus multilocularis muscleblind protein 1 0.0307 0.0938 0.0938
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0078 0.0078
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0058 0.0058
Loa Loa (eye worm) voltage-gated potassium channel 0.019 0.0564 0.0564
Loa Loa (eye worm) hypothetical protein 0.0203 0.0604 0.0604
Loa Loa (eye worm) hypothetical protein 0.019 0.0564 0.0564
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0058 0.0083
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0004
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0149 0.0146
Schistosoma mansoni nuclear receptor 0.0015 0.0004 0.0001
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0149 0.2225
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.019 0.0564 0.0564
Echinococcus multilocularis short transient receptor potential channel 6 0.019 0.0564 0.0564
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0047 0.0044
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0004
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0495 0.5619
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.2049 0.6507 0.6507
Echinococcus multilocularis tyrosine protein kinase HCK 0.0035 0.0069 0.0069
Schistosoma mansoni tar DNA-binding protein 0.0067 0.017 0.0167
Brugia malayi TAR-binding protein 0.0067 0.017 0.0167
Echinococcus granulosus tyrosine protein kinase Lyn 0.005 0.0115 0.0115
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0058 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0058 0.0055
Loa Loa (eye worm) hypothetical protein 0.019 0.0564 0.0564
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.005 0.0115 0.0115
Schistosoma mansoni hypothetical protein 0.0018 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.019 0.0564 0.0564
Echinococcus multilocularis carbonic anhydrase 0.0034 0.0063 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0058 0.0055
Echinococcus multilocularis carbonic anhydrase 0.0034 0.0063 0.0063
Schistosoma mansoni voltage-gated potassium channel 0.019 0.0564 0.0562
Schistosoma mansoni carbonic anhydrase 0.0034 0.0063 0.006
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0778 0.9363
Schistosoma mansoni transient receptor potential channel 0.019 0.0564 0.0562
Schistosoma mansoni tyrosine kinase 0.0018 0.0013 0.001
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.019 0.0564 0.0564
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0004 0.0004
Echinococcus multilocularis sodium leak channel non selective protein 0.019 0.0564 0.0564
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.019 0.0564 0.0562
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0147 0.0427 0.7209
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.0621 0.0621
Echinococcus multilocularis inhibitor of apoptosis protein 0.2049 0.6507 0.6507
Schistosoma mansoni voltage-gated potassium channel 0.019 0.0564 0.0562
Schistosoma mansoni carbonic anhydrase-related 0.0034 0.0063 0.006
Loa Loa (eye worm) RNA binding protein 0.0067 0.017 0.017
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0083 0.008
Loa Loa (eye worm) hypothetical protein 0.019 0.0564 0.0564
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0015 0.0015
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0058 0.0055
Brugia malayi Tyrosine-protein kinase abl-1 0.0139 0.0402 0.0399
Schistosoma mansoni cpg binding protein 0.0033 0.0063 0.006
Brugia malayi RhoGAP domain containing protein 0.0016 0.0007 0.0004
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.019 0.0564 0.0564
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0495 0.5619
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0016 0.0007 0.0004
Schistosoma mansoni transient receptor potential channel 0.019 0.0564 0.0562
Brugia malayi Matrixin family protein 0.0203 0.0604 0.0601
Echinococcus granulosus caspase 2 0.0687 0.2154 0.2154
Leishmania major carbonic anhydrase-like protein 0.0147 0.0427 0.7421
Loa Loa (eye worm) TK/ABL protein kinase 0.0236 0.0712 0.0712
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0015 0.0004 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0058 0.0058
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0071 0.2995
Brugia malayi nuclear hormone receptor family member odr-7 0.0015 0.0004 0.0001
Schistosoma mansoni voltage-gated potassium channel 0.019 0.0564 0.0562
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.019 0.0564 0.0564
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.019 0.0564 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0058 0.0058
Loa Loa (eye worm) matrixin family protein 0.049 0.1523 0.1523
Echinococcus granulosus transient receptor potential cation channel 0.019 0.0564 0.0564
Echinococcus multilocularis transient receptor potential cation channel 0.019 0.0564 0.0564
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.0047
Echinococcus granulosus potassium voltage gated channel subfamily H 0.019 0.0564 0.0564
Loa Loa (eye worm) hypothetical protein 0.019 0.0564 0.0564
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0149 0.2225
Echinococcus granulosus two pore calcium channel protein 2 0.019 0.0564 0.0564
Onchocerca volvulus 0.0032 0.0058 0.0083
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.001 0.0007
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.005 0.0115 0.0115
Echinococcus granulosus short transient receptor potential channel 6 0.019 0.0564 0.0564
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0058 0.0055
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.003 0.5
Onchocerca volvulus Matrilysin homolog 0.0203 0.0604 0.0923
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0058 0.0055
Schistosoma mansoni voltage-gated potassium channel 0.019 0.0564 0.0562
Echinococcus granulosus transient receptor potential cation channel 0.019 0.0564 0.0564
Echinococcus multilocularis voltage gated hydrogen channel 1 0.019 0.0564 0.0564
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0004
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.019 0.0564 0.0564
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.019 0.0564 0.0562
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.019 0.0564 0.0564
Echinococcus multilocularis c src tyrosine kinase 0.0018 0.0013 0.0013
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0058 0.0055
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0058 0.0058
Schistosoma mansoni voltage-gated potassium channel 0.019 0.0564 0.0562
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.3141 1 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0111 0.0108
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.0474 0.0474
Brugia malayi glutaminase DH11.1 0.0272 0.0826 0.0823
Loa Loa (eye worm) hypothetical protein 0.019 0.0564 0.0564
Loa Loa (eye worm) matrix metalloproteinase 0.0203 0.0604 0.0604
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0004 0.0001
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0034 0.0063 0.006
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0166 0.0163
Toxoplasma gondii hypothetical protein 0.0034 0.0063 0.0616
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0147 0.0427 0.0427
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0034 0.0063 0.006
Loa Loa (eye worm) TK protein kinase 0.0035 0.0069 0.0069
Echinococcus multilocularis tyrosine protein kinase Fyn 0.005 0.0115 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0058 0.0055
Schistosoma mansoni cpg binding protein 0.0032 0.0057 0.0054
Loa Loa (eye worm) hypothetical protein 0.0034 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0034 0.0063 0.0063
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0058 0.0058
Brugia malayi Pre-SET motif family protein 0.0208 0.0621 0.0618
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0111 0.0111
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0058 0.0083
Echinococcus multilocularis tyrosine protein kinase Src64B 0.005 0.0115 0.0115
Schistosoma mansoni hypothetical protein 0.0018 0.0015 0.0012
Trichomonas vaginalis set domain proteins, putative 0.0236 0.0712 0.8491
Brugia malayi Tyrosine-protein kinase abl-1 0.0104 0.0289 0.0287
Echinococcus granulosus hypothetical protein 0.019 0.0564 0.0564
Onchocerca volvulus Glucosylceramidase homolog 0.0169 0.0495 0.0755
Loa Loa (eye worm) hypothetical protein 0.019 0.0564 0.0564
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.019 0.0564 1
Schistosoma mansoni voltage-gated ion channel 0.019 0.0564 0.0562
Onchocerca volvulus Matrilysin homolog 0.0449 0.1393 0.2136
Loa Loa (eye worm) hypothetical protein 0.0687 0.2154 0.2154
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.019 0.0564 0.0562
Onchocerca volvulus 0.0287 0.0875 0.1339
Schistosoma mansoni voltage-gated potassium channel 0.019 0.0564 0.0562
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.001 0.001
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0737 0.2312 0.2312
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.3141 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.019 0.0564 0.0564
Loa Loa (eye worm) TAR-binding protein 0.0067 0.017 0.017
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.019 0.0564 0.0564
Brugia malayi nuclear receptor NHR-67 0.0015 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0307 0.0938 0.0938
Brugia malayi Muscleblind-like protein 0.0307 0.0938 0.0935
Echinococcus multilocularis transient receptor potential cation channel 0.019 0.0564 0.0564
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0004 0.0004
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0015 0.0015
Brugia malayi Matrixin family protein 0.0203 0.0604 0.0601
Loa Loa (eye worm) hypothetical protein 0.0032 0.0058 0.0058
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.019 0.0564 0.0562
Echinococcus granulosus sodium leak channel non selective protein 0.019 0.0564 0.0564
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.001 0.0007
Loa Loa (eye worm) TK protein kinase 0.0043 0.0092 0.0092
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0058 0.0055
Echinococcus multilocularis transient receptor potential cation channel 0.019 0.0564 0.0564
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0003
Brugia malayi ecdysone receptor 0.0015 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0004
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0058 0.0058
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0048 0.0048
Echinococcus multilocularis ryanodine receptor 44f 0.019 0.0564 0.0564
Mycobacterium ulcerans glutaminase 0.0272 0.0826 1
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0778 0.9363
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0058 0.0055
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.019 0.0564 0.0562
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.001
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0015 0.0004 0.0001
Echinococcus multilocularis nuclear receptor nhr 48 0.0015 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.019 0.0564 0.0564
Loa Loa (eye worm) hypothetical protein 0.019 0.0564 0.0564
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0058 0.0058
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0058 0.0058
Schistosoma mansoni tyrosine kinase 0.0229 0.0688 0.0686
Loa Loa (eye worm) hypothetical protein 0.019 0.0564 0.0564
Schistosoma mansoni tyrosine kinase 0.005 0.0115 0.0113
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0336 0.0336
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.3141 1 1
Echinococcus multilocularis NCK adaptor protein 0.0015 0.0003 0.0003
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0495 0.5619
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0058 0.0055
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.019 0.0564 0.0562
Loa Loa (eye worm) ion channel NompC 0.019 0.0564 0.0564
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0004
Brugia malayi nuclear receptor RXR 0.0017 0.001 0.0007
Schistosoma mansoni hypothetical protein 0.0018 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.0032 0.0058 0.0058
Brugia malayi cation channel family protein 0.019 0.0564 0.0562
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0053 0.005
Echinococcus granulosus microtubule associated protein 2 0.1418 0.4491 0.4491
Onchocerca volvulus Matrix metalloproteinase homolog 0.0449 0.1393 0.2136
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.017 0.017
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0016 0.0007 0.0007
Echinococcus granulosus carbonic anhydrase 0.0034 0.0063 0.0063
Echinococcus granulosus growth factor receptor bound protein 2 0.0015 0.0003 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0053 0.005
Echinococcus granulosus tyrosine protein kinase Blk 0.0043 0.0092 0.0092
Brugia malayi CXXC zinc finger family protein 0.0032 0.0057 0.0054
Loa Loa (eye worm) hypothetical protein 0.019 0.0564 0.0564
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.0474 0.0474
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.019 0.0564 0.6535
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0015
Schistosoma mansoni transient receptor potential channel 0.019 0.0564 0.0562
Schistosoma mansoni tyrosine kinase 0.005 0.0115 0.0113
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0034 0.0063 0.006
Onchocerca volvulus 0.0236 0.0712 0.1089
Echinococcus multilocularis transient receptor potential cation channel 0.019 0.0564 0.0564
Schistosoma mansoni tar DNA-binding protein 0.0067 0.017 0.0167
Echinococcus granulosus hyperpolarization activated cyclic 0.019 0.0564 0.0564
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0004
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0058 0.0058
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.019 0.0564 0.6535
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0057 0.0057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0058 0.0058
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0004 0.0004
Wolbachia endosymbiont of Brugia malayi extracellular metallopeptidase 0.257 0.8175 1
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0778 0.9363
Schistosoma mansoni hypothetical protein 0.2049 0.6507 0.6506
Brugia malayi hypothetical protein 0.0017 0.001 0.0007
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.019 0.0564 0.0562
Schistosoma mansoni vesicular amine transporter 0.019 0.0564 0.0562
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0016 0.0007 0.0007
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.001 0.0007
Schistosoma mansoni two-pore calcium channel 0.019 0.0564 0.0562
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0058 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0058 0.0055
Echinococcus multilocularis tyrosine protein kinase Fgr 0.005 0.0115 0.0115
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0166 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0058 0.0055
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.0221 0.0221
Brugia malayi Hemopexin family protein 0.0287 0.0875 0.0872
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.019 0.0564 1
Brugia malayi Matrixin family protein 0.0203 0.0604 0.0601
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0071 0.0071
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0257 0.0778 0.0775
Echinococcus granulosus transient receptor potential cation channel 0.019 0.0564 0.0564
Loa Loa (eye worm) hypothetical protein 0.2049 0.6507 0.6507
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.019 0.0564 0.0562
Brugia malayi nuclear receptor RXR 0.0015 0.0004 0.0001
Echinococcus multilocularis musashi 0.0029 0.0047 0.0047
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.019 0.0564 0.0564
Onchocerca volvulus 0.2049 0.6507 1
Echinococcus granulosus c src tyrosine kinase 0.0018 0.0013 0.0013
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.0221 0.0221
Schistosoma mansoni alpha-glucosidase 0.014 0.0402 0.04
Onchocerca volvulus 0.0032 0.0057 0.0081
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0043 0.0092 0.0092
Leishmania major hypothetical protein, unknown function 0.019 0.0564 1
Onchocerca volvulus 0.0029 0.0047 0.0066
Echinococcus multilocularis TRP (transient receptor potential) channel 0.019 0.0564 0.0564
Onchocerca volvulus 0.003 0.0053 0.0076
Echinococcus granulosus voltage dependent calcium channel 0.3141 1 1
Echinococcus multilocularis voltage dependent calcium channel 0.3141 1 1
Echinococcus granulosus voltage gated potassium channel 0.019 0.0564 0.0564
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0071 0.0761
Echinococcus multilocularis carbonic anhydrase 0.0034 0.0063 0.0063
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0015 0.0004 0.0001
Echinococcus granulosus tyrosine kinase 0.0043 0.0092 0.0092
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0737 0.2312 0.2312
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0058 0.0058
Brugia malayi nuclear receptor NHR-88 0.0015 0.0004 0.0001
Echinococcus granulosus tyrosine protein kinase Src64B 0.005 0.0115 0.0115
Schistosoma mansoni hypothetical protein 0.0287 0.0875 0.0872
Echinococcus multilocularis conserved hypothetical protein 0.019 0.0564 0.0564
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0162 0.0474 0.0474
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.0221 0.0218
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0111 0.0108
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0015 0.0015
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.001 0.001
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0071 0.2995
Echinococcus multilocularis two pore calcium channel protein 2 0.019 0.0564 0.0564
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0058 0.0055
Plasmodium vivax SET domain protein, putative 0.003 0.0053 1
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.019 0.0564 0.0562
Echinococcus granulosus muscleblind protein 0.0307 0.0938 0.0938
Schistosoma mansoni glutaminase 0.0272 0.0826 0.0823
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0524 0.6004
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0058 0.0058
Echinococcus multilocularis transient receptor potential gamma protein 0.019 0.0564 0.0564
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0058 0.0055
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0058 0.0058
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0166 0.1926
Echinococcus granulosus ryanodine receptor 44f 0.019 0.0564 0.0564
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.017 0.0167
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.005 0.0115 0.0115
Echinococcus multilocularis growth factor receptor bound protein 2 0.0015 0.0003 0.0003
Brugia malayi RNA binding protein 0.0067 0.017 0.0167
Schistosoma mansoni lamin 0.0029 0.0047 0.0044
Schistosoma mansoni hypothetical protein 0.004 0.0083 0.008
Loa Loa (eye worm) nuclear receptor NHR-67 0.0015 0.0004 0.0004
Brugia malayi SRC-1 0.005 0.0115 0.0113
Loa Loa (eye worm) hypothetical protein 0.019 0.0564 0.0564
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0034 0.0063 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0058 0.0055
Echinococcus granulosus nuclear receptor nhr 48 0.0015 0.0004 0.0004
Echinococcus multilocularis raf serine:threonine protein kinase 0.0246 0.0741 0.0741
Echinococcus multilocularis tyrosine protein kinase Srms 0.0043 0.0092 0.0092
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.3141 1 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.019 0.0564 0.0562
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0058 0.0055
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0004
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0058 0.0055
Schistosoma mansoni inositol 145-trisphosphate receptor 0.019 0.0564 0.0562
Loa Loa (eye worm) nuclear hormone receptor 0.0015 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.3141 1 1
Brugia malayi nuclear hormone receptor 0.0032 0.0058 0.0055
Brugia malayi steroid hormone receptor 0.0032 0.0058 0.0055
Echinococcus multilocularis potassium voltage gated channel protein 0.019 0.0564 0.0564
Echinococcus granulosus potassium voltage gated channel protein 0.019 0.0564 0.0564
Leishmania major hypothetical protein, conserved 0.019 0.0564 1
Loa Loa (eye worm) voltage-dependent calcium channel 0.019 0.0564 0.0564
Echinococcus multilocularis potassium large conductance calcium activated 0.019 0.0564 0.0564
Brugia malayi tailless protein 0.0015 0.0004 0.0001
Loa Loa (eye worm) voltage-gated potassium channel 0.019 0.0564 0.0564
Echinococcus multilocularis potassium voltage gated channel protein 0.019 0.0564 0.0564
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0495 0.5619
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0004 0.0001
Echinococcus granulosus transient receptor potential cation channel 0.019 0.0564 0.0564
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0016 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0179 0.0529 0.0526
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0058 0.0083
Loa Loa (eye worm) hypothetical protein 0.0203 0.0604 0.0604
Echinococcus granulosus lamin dm0 0.0029 0.0047 0.0047
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.019 0.0564 0.0562
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.001 0.001
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.019 0.0564 0.0564
Echinococcus granulosus raf serine:threonine protein kinase 0.0246 0.0741 0.0741
Brugia malayi MH2 domain containing protein 0.0119 0.0336 0.0333
Mycobacterium ulcerans hydrolase 0.0247 0.0745 0.8986
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0147 0.0427 0.0424
Loa Loa (eye worm) calcium channel 0.3141 1 1
Schistosoma mansoni voltage-gated potassium channel 0.019 0.0564 0.0562
Schistosoma mansoni serine/threonine protein kinase 0.0246 0.0741 0.0739
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.2049 0.6507 0.6506
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0257 0.0778 0.0778
Schistosoma mansoni voltage-gated potassium channel 0.019 0.0564 0.0562
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.019 0.0564 0.0564
Schistosoma mansoni tar DNA-binding protein 0.0067 0.017 0.0167
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.019 0.0564 0.0564
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0495 0.5619
Echinococcus multilocularis caspase 2 0.0687 0.2154 0.2154
Loa Loa (eye worm) raf kinase 0.0242 0.0731 0.0731
Brugia malayi conserved hypotetical protein 0.0015 0.0004 0.0001
Schistosoma mansoni voltage-gated potassium channel 0.019 0.0564 0.0562
Loa Loa (eye worm) hypothetical protein 0.0237 0.0714 0.0714
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0043 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.019 0.0564 0.0564
Echinococcus granulosus calcium activated potassium channel 0.019 0.0564 0.0564
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.019 0.0564 0.0562
Schistosoma mansoni transient receptor potential channel 4 0.019 0.0564 0.0562
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0071 0.0761
Schistosoma mansoni polycystin 1-related 0.0226 0.0678 0.0676
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0004 0.0001
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.3141 1 1
Echinococcus granulosus inhibitor of apoptosis protein 0.2049 0.6507 0.6507
Brugia malayi Raf kinase 0.0237 0.0714 0.0712
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0247 0.0745 1
Echinococcus granulosus lamin 0.0029 0.0047 0.0047
Echinococcus granulosus hyperpolarization activated cyclic 0.019 0.0564 0.0564
Echinococcus granulosus potassium voltage gated channel protein 0.019 0.0564 0.0564
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0004
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0053 0.0053
Echinococcus multilocularis short transient receptor potential channel 6 0.019 0.0564 0.0564
Brugia malayi hypothetical protein 0.0687 0.2154 0.2152
Schistosoma mansoni ryanodine receptor related 0.019 0.0564 0.0562
Echinococcus multilocularis shaker cognate 0.019 0.0564 0.0564
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.019 0.0564 0.0562
Loa Loa (eye worm) voltage-gated calcium channel 0.019 0.0564 0.0564
Brugia malayi nuclear receptor NHR-88 0.0032 0.0058 0.0055
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0197 0.0587 0.0587
Onchocerca volvulus Cell death protein 3 homolog 0.0687 0.2154 0.3306
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.019 0.0564 0.0564
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0166 0.1926
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0147 0.0427 0.0424
Echinococcus granulosus voltage dependent calcium channel 0.019 0.0564 0.0564
Schistosoma mansoni voltage-gated potassium channel 0.019 0.0564 0.0562
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.0221 0.0218
Echinococcus granulosus carbonic anhydrase 0.0034 0.0063 0.0063
Echinococcus granulosus potassium voltage gated channel protein 0.019 0.0564 0.0564
Loa Loa (eye worm) hypothetical protein 0.019 0.0564 0.0564
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0058 0.0055
Loa Loa (eye worm) hypothetical protein 0.0687 0.2154 0.2154
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0778 0.9363
Brugia malayi hypothetical protein 0.019 0.0564 0.0562
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.019 0.0564 0.0562
Trichomonas vaginalis glutaminase, putative 0.0272 0.0826 1
Schistosoma mansoni voltage-gated potassium channel 0.019 0.0564 0.0562
Echinococcus multilocularis transient receptor potential cation channel 0.019 0.0564 0.0564
Schistosoma mansoni nuclear receptor nhr-48 0.0015 0.0004 0.0001
Entamoeba histolytica protein kinase, putative 0.0035 0.0069 0.2809
Echinococcus granulosus potassium voltage gated channel subfamily H 0.019 0.0564 0.0564
Schistosoma mansoni nuclear receptor 0.0015 0.0004 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0053 0.005
Echinococcus granulosus voltage gated potassium channel 0.019 0.0564 0.0564
Schistosoma mansoni hypothetical protein 0.019 0.0564 0.0562
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.019 0.0564 0.0564
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0058 0.0055
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.019 0.0564 0.0564
Schistosoma mansoni voltage-gated cation channel 0.3141 1 1
Echinococcus granulosus TRP transient receptor potential channel 0.019 0.0564 0.0564
Brugia malayi olfactory channel protein osm-9 0.019 0.0564 0.0562
Loa Loa (eye worm) hypothetical protein 0.0032 0.0058 0.0058
Echinococcus granulosus baculoviral IAP repeat containing protein 0.2049 0.6507 0.6507
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0016 0.0007 0.0004
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0015 0.0004 0.0001
Schistosoma mansoni hypothetical protein 0.0179 0.0529 0.0526
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0058 0.0058
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0149 0.1494
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0053 0.005
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.3141 1 1
Mycobacterium leprae PROBABLE HYDROLASE 0.0247 0.0745 1
Plasmodium falciparum carbonic anhydrase 0.0034 0.0063 1
Loa Loa (eye worm) hypothetical protein 0.019 0.0564 0.0564
Echinococcus granulosus tyrosine protein kinase Fyn 0.005 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0004
Brugia malayi Matrixin family protein 0.049 0.1523 0.1521
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0173 0.0171
Loa Loa (eye worm) hypothetical protein 0.0032 0.0058 0.0058
Brugia malayi hypothetical protein 0.0017 0.001 0.0007
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.019 0.0564 1
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.019 0.0564 0.0564
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.019 0.0564 0.0562
Brugia malayi intermediate filament protein 0.0029 0.0047 0.0044
Schistosoma mansoni cpg binding protein 0.0033 0.0063 0.006
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.2049 0.6507 0.6506
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0166 0.0166
Schistosoma mansoni voltage-gated potassium channel 0.019 0.0564 0.0562
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0166 0.0166
Echinococcus multilocularis transient receptor potential cation channel 0.019 0.0564 0.0564
Echinococcus multilocularis geminin 0.0179 0.0529 0.0529
Echinococcus granulosus potassium voltage gated channel subfamily C 0.019 0.0564 0.0564
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0236 0.0712 0.0712
Echinococcus granulosus potassium large conductance calcium activated 0.019 0.0564 0.0564
Echinococcus granulosus tyrosine protein kinase ABL1 0.0236 0.0712 0.0712
Schistosoma mansoni microtubule-associated protein tau 0.1418 0.4491 0.4489
Echinococcus granulosus tyrosine protein kinase Fyn 0.005 0.0115 0.0115
Brugia malayi Glycosyl hydrolases family 31 protein 0.0162 0.0474 0.0472
Echinococcus granulosus apoptotic protease activating factor 1 0.0687 0.2154 0.2154
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0058 0.0058
Echinococcus granulosus potassium voltage gated channel subfamily A 0.019 0.0564 0.0564
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.001
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0058 0.0055
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0058 0.0055
Brugia malayi orphan nuclear receptor NR2E1 0.0015 0.0004 0.0001
Schistosoma mansoni tar DNA-binding protein 0.0067 0.017 0.0167
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0166 0.2541
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.001
Loa Loa (eye worm) glutaminase 2 0.0272 0.0826 0.0826
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0149 0.1494
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0018 0.0013 0.001
Schistosoma mansoni tyrosine kinase 0.0018 0.0013 0.001
Loa Loa (eye worm) hypothetical protein 0.0032 0.0058 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0058 0.0058
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0004 0.0004
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0058 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0058 0.0055
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0058 0.0058
Brugia malayi ecdysteroid receptor 0.0032 0.0058 0.0055
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0058 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0058 0.0058
Echinococcus granulosus voltage gated hydrogen channel 1 0.019 0.0564 0.0564
Schistosoma mansoni calcium-activated potassium channel 0.019 0.0564 0.0562
Loa Loa (eye worm) hypothetical protein 0.019 0.0564 0.0564
Echinococcus multilocularis lamin 0.0029 0.0047 0.0047
Schistosoma mansoni intermediate filament proteins 0.0029 0.0047 0.0044
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0149 0.0149
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0166 0.0166
Toxoplasma gondii hypothetical protein 0.019 0.0564 1
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.019 0.0564 0.0562
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0166 0.2541
Loa Loa (eye worm) hypothetical protein 0.009 0.0243 0.0243
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0015 0.0003 0.0003
Echinococcus multilocularis carbonic anhydrase II 0.0147 0.0427 0.0427
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.019 0.0564 0.0562
Echinococcus multilocularis cpg binding protein 0.0033 0.0063 0.0063
Echinococcus granulosus sodium channel protein 0.019 0.0564 0.0564
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.2049 0.6507 0.6506
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.019 0.0564 0.0562
Echinococcus multilocularis apoptotic protease activating factor 1 0.0687 0.2154 0.2154
Echinococcus multilocularis voltage dependent calcium channel 0.3141 1 1
Trypanosoma brucei glucosidase, putative 0.0036 0.0071 0.0761
Loa Loa (eye worm) hypothetical protein 0.0032 0.0058 0.0058
Schistosoma mansoni coup transcription factor 0.0032 0.0058 0.0055
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0203 0.0604 0.0601
Echinococcus granulosus cyclic nucleotide gated cation channel 0.019 0.0564 0.0564
Echinococcus granulosus carbonic anhydrase II 0.0147 0.0427 0.0427
Schistosoma mansoni tar DNA-binding protein 0.0067 0.017 0.0167
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0495 0.5619
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.019 0.0564 0.0562
Echinococcus granulosus GPCR family 2 0.0018 0.0015 0.0015
Toxoplasma gondii hypothetical protein 0.019 0.0564 1
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.019 0.0564 0.0562
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0005 0.0002
Loa Loa (eye worm) matrixin family protein 0.0449 0.1393 0.1393
Echinococcus granulosus tar DNA binding protein 0.0067 0.017 0.017
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.3141 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0778 0.9363
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0111 0.0108
Echinococcus granulosus cpg binding protein 0.0033 0.0063 0.0063
Echinococcus granulosus tyrosine protein kinase Src42A 0.005 0.0115 0.0115
Brugia malayi hypothetical protein 0.0015 0.0004 0.0001
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0015 0.0004 0.0004
Echinococcus granulosus transient receptor potential cation channel 0.019 0.0564 0.0564
Echinococcus multilocularis voltage gated potassium channel 0.019 0.0564 0.0564
Onchocerca volvulus 0.0094 0.0256 0.0387
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.3141 1 1
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.019 0.0564 0.0564
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.005 0.0115 0.0115
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0058 0.0055
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.019 0.0564 0.0562
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0015 0.0004 0.0004

Activities

Activity type Activity value Assay description Source Reference
Kd (binding) = 94 nM Dissociation constant against human carbonic anhydrase II at 37 degree centigrade ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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