Detailed information for compound 175087

Basic information

Technical information
  • TDR Targets ID: 175087
  • Name: 4-(3-hydroxybutyl)phenol
  • MW: 166.217 | Formula: C10H14O2
  • H donors: 2 H acceptors: 2 LogP: 1.93 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(CCc1ccc(cc1)O)O
  • InChi: 1S/C10H14O2/c1-8(11)2-3-9-4-6-10(12)7-5-9/h4-8,11-12H,2-3H2,1H3
  • InChiKey: SFUCGABQOMYVJW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • rhododendrol
  • 69617-84-1
  • AI3-31843
  • Benzenepropanol, 4-hydroxy-alpha-methyl-
  • STK015339
  • 4-(p-Hydroxyphenyl)butan-2-ol
  • MLS001048912
  • SMR000037104
  • EINECS 274-056-1
  • 2-Butanol, 4-(p-hydroxyphenyl)-
  • Benzenepropanol, 4-hydroxy-.alpha.-methyl-, (R)-
  • 4-(p-Hydroxyphenyl)-2-butanol
  • Benzenepropanol, 4-hydroxy-.alpha.-methyl-
  • NSC40514

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Human immunodeficiency virus 1 Aberrant vpr protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis dnaJ subfamily B 0.044 0.3452 0.3451
Onchocerca volvulus 0.0012 0.0021 0.0164
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0238 0.183 0.183
Loa Loa (eye worm) hypothetical protein 0.0043 0.0273 0.0272
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Schistosoma mansoni hypothetical protein 0.0015 0.0047 0.0036
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0273 0.0163
Schistosoma mansoni neuropeptide receptor 0.0012 0.0021 0.0009
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0011
Echinococcus granulosus g protein coupled receptor 0.0012 0.0021 0.002
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0238 0.183 0.1738
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0011
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0021 0.002
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0012 0.0011
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0313 0.0313
Giardia lamblia Phosphatidylinositol 4-kinase 0.0081 0.0574 0.0468
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0012 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0021 0.0009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0112 0.0111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0678 0.5365 0.5312
Trichomonas vaginalis PIKK family atypical protein kinase 0.0934 0.7418 0.7389
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0012 0.0011
Echinococcus granulosus g-protein coupled receptor 0.0012 0.0021 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0157 0.118 0.108
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0081 0.0574 0.0468
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0313 0.0312
Plasmodium vivax hypothetical protein, conserved 0.0081 0.0574 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0012 0.0021 0.002
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0273 0.0272
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0238 0.183 0.183
Brugia malayi hypothetical protein 0.0012 0.0021 0.0021
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0081 0.0574 0.047
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0179 0.0092
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0012 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0157 0.118 0.108
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0012 0.0021 0.002
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0081 0.0574 0.0574
Trichomonas vaginalis PIKK family atypical protein kinase 0.0677 0.5357 0.5304
Brugia malayi FAT domain containing protein 0.0184 0.1398 0.1398
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0021 0.002
Echinococcus granulosus dro:myosuppressin receptor 0.0012 0.0021 0.002
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.1256 1 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0012 0.0012
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0081 0.0574 0.0468
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0421 0.3303 0.3228
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0081 0.0574 0.047
Entamoeba histolytica hypothetical protein 0.0081 0.0574 0.047
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0017 0.0062 0.0062
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0021 0.002
Echinococcus multilocularis GPCR, family 2 0.0015 0.0047 0.0046
Schistosoma mansoni fkbp-rapamycin associated protein 0.0238 0.183 0.1821
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0131 0.0019
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0012 0.0012
Echinococcus multilocularis neuropeptides capa receptor 0.0012 0.0021 0.002
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0012 0.0021 0.0009
Schistosoma mansoni neuropeptide receptor 0.0012 0.0021 0.0009
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0238 0.183 0.1738
Schistosoma mansoni hypothetical protein 0.0033 0.019 0.0179
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0081 0.0574 0.0574
Echinococcus granulosus neuropeptides capa receptor 0.0012 0.0021 0.002
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0421 0.3303 0.3229
Schistosoma mansoni cpg binding protein 0.0033 0.0186 0.0175
Brugia malayi hypothetical protein 0.0012 0.0021 0.0021
Brugia malayi steroid hormone receptor 0.0011 0.0012 0.0012
Brugia malayi Dopamine receptor 0.0012 0.0021 0.0021
Onchocerca volvulus 0.0012 0.0021 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0743 0.5885 0.5839
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0109 0.0109
Schistosoma mansoni hypothetical protein 0.0015 0.0047 0.0036
Schistosoma mansoni neuropeptide F-like receptor 0.0012 0.0021 0.0009
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0081 0.0574 0.0468
Echinococcus multilocularis neuropeptide Y receptor 0.0012 0.0021 0.002
Onchocerca volvulus 0.0012 0.0021 0.0164
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0012 0.0011
Brugia malayi putative neuropeptide receptor 0.0012 0.0021 0.0021
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0021 0.002
Echinococcus granulosus neuropeptide receptor 0.0012 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Brugia malayi putative neuropeptide receptor NPR1 0.0012 0.0021 0.0021
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0273 0.104
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.1256 1 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0012 0.0021 0.0009
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0273 0.0262
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0081 0.0574 0.0468
Schistosoma mansoni amine GPCR 0.0012 0.0021 0.0009
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0081 0.0574 0.0468
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0081 0.0574 0.0468
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0421 0.3303 0.3303
Schistosoma mansoni amine GPCR 0.0012 0.0021 0.0009
Schistosoma mansoni importin beta-1 0.0032 0.0179 0.0168
Onchocerca volvulus Neuropeptide F receptor homolog 0.0012 0.0021 0.0164
Plasmodium falciparum importin beta, putative 0.0032 0.0179 0.2275
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0313 0.0313
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0012 0.0021 0.002
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0081 0.0574 0.0574
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0109 0.0259
Brugia malayi G-protein coupled receptor 0.0012 0.0021 0.0021
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0109 0.222
Loa Loa (eye worm) hypothetical protein 0.0032 0.0179 0.0178
Mycobacterium tuberculosis Conserved protein 0.0043 0.0273 0.104
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0012 0.0011
Mycobacterium leprae Probable lipase LipE 0.0043 0.0273 0.3521
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0081 0.0574 0.0468
Echinococcus multilocularis serotonin receptor 0.0012 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0023 0.0109 0.0108
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0021 0.002
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0012 0.0021 0.0009
Brugia malayi GnHR receptor homolog 0.0012 0.0021 0.0021
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0021 0.002
Schistosoma mansoni hypothetical protein 0.0176 0.1338 0.1328
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0012 0.0021 0.002
Loa Loa (eye worm) phosphatidylinositol 3 0.0081 0.0574 0.0574
Brugia malayi Serotonin receptor 0.0012 0.0021 0.0021
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0273 0.0262
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0184 0.1398 0.1397
Trichomonas vaginalis PIKK family atypical protein kinase 0.0421 0.3303 0.3228
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0081 0.0574 0.0468
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0021 0.002
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0081 0.0574 1
Echinococcus multilocularis 0.0081 0.0574 0.0574
Entamoeba histolytica hypothetical protein 0.0238 0.183 0.174
Brugia malayi AKH receptor 0.0012 0.0021 0.0021
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0081 0.0574 0.0468
Loa Loa (eye worm) hypothetical protein 0.0017 0.0062 0.0062
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0702 0.0701
Loa Loa (eye worm) phosphatidylinositol 3 0.0081 0.0574 0.0574
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0081 0.0574 0.047
Echinococcus multilocularis cpg binding protein 0.0033 0.0186 0.0185
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.1256 1 1
Onchocerca volvulus 0.0012 0.0021 0.0164
Onchocerca volvulus 0.0023 0.0109 0.1736
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0012 0.0021 0.002
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0012 0.0021 0.0009
Trypanosoma cruzi target of rapamycin kinase 3 0.1 0.7947 0.7924
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0081 0.0574 0.0574
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0012 0.0011
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0238 0.183 0.174
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0012 0.0021 0.0021
Echinococcus multilocularis orexin receptor type 2 0.0012 0.0021 0.002
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0109 0.222
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Brugia malayi Dopamine receptor protein 1 0.0012 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0015 0.0047 0.0046
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0081 0.0574 0.0633
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0112 0.0112
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0131 0.0019
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0081 0.0574 0.0468
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0021 0.0009
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0081 0.0574 0.047
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.1256 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0238 0.183 0.1738
Echinococcus granulosus 7TM GPCR rhodopsin 0.0012 0.0021 0.002
Onchocerca volvulus 0.0081 0.0574 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Schistosoma mansoni amine GPCR 0.0012 0.0021 0.0009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0574 0.0468
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1 0.7947 0.7924
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0081 0.0574 0.0468
Echinococcus multilocularis neuropeptides capa receptor 0.0012 0.0021 0.002
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0047 0.0046
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0012 0.0021 0.002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0012 0.0011
Loa Loa (eye worm) phosphatidylinositol 3 0.0081 0.0574 0.0574
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0421 0.3303 0.3303
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0047 0.0046
Echinococcus granulosus hypothetical protein 0.0012 0.0021 0.002
Leishmania major hypothetical protein, conserved 0.0081 0.0574 0.047
Leishmania major phosphatidylinositol 4-kinase, putative 0.0081 0.0574 0.047
Schistosoma mansoni hypothetical protein 0.0012 0.0021 0.0009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Brugia malayi G protein-coupled receptor F59B2.13 0.0012 0.0021 0.0021
Echinococcus multilocularis G protein coupled receptor 139 0.0012 0.0021 0.002
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0273 0.104
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0012 0.0021 0.002
Brugia malayi RNA, U transporter 1 0.009 0.0648 0.0648
Loa Loa (eye worm) phosphatidylinositol 3 0.0421 0.3303 0.3303
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0081 0.0574 0.0468
Echinococcus granulosus dnaJ subfamily B 0.044 0.3452 0.3451
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0021 0.0009
Echinococcus granulosus neuropeptide s receptor 0.0012 0.0021 0.002
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0421 0.3303 0.3228
Onchocerca volvulus 0.0012 0.0021 0.0164
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0012 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0999 0.7938 0.7915
Schistosoma mansoni adenoreceptor 0.0012 0.0021 0.0009
Brugia malayi hypothetical protein 0.0012 0.0021 0.0021
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0273 0.0163
Schistosoma mansoni neuropeptide receptor 0.0012 0.0021 0.0009
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0081 0.0574 0.0564
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0081 0.0574 0.0468
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0081 0.0574 0.0574
Echinococcus granulosus serine protein kinase ATM 0.0238 0.183 0.1829
Toxoplasma gondii FATC domain-containing protein 0.0238 0.183 0.2352
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0081 0.0574 0.0564
Schistosoma mansoni hypothetical protein 0.0015 0.0047 0.0036
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0021 0.002
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1 0.7947 0.7924
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0043 0.0273 0.0272
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0081 0.0574 1
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0594 0.4689 0.4629
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0273 0.104
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0012 0.0011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0021 0.002
Schistosoma mansoni neuropeptide F-like receptor 0.0012 0.0021 0.0009
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0273 0.0163
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0273 0.104
Plasmodium vivax hypothetical protein 0.0081 0.0574 1
Loa Loa (eye worm) hypothetical protein 0.0238 0.183 0.1829
Trichomonas vaginalis PIKK family atypical protein kinase 0.0678 0.5365 0.5312
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0265 0.2048 0.265
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Entamoeba histolytica hypothetical protein 0.0081 0.0574 0.047
Loa Loa (eye worm) hypothetical protein 0.0017 0.0062 0.0062
Leishmania major phosphatidylinositol 3-kinase, putative 0.0081 0.0574 0.047
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0081 0.0574 0.047
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0081 0.0574 0.0468
Trichomonas vaginalis PIKK family atypical protein kinase 0.0816 0.6465 0.6425
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0081 0.0574 0.0574
Trichomonas vaginalis PIKK family atypical protein kinase 0.0421 0.3303 0.3228
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0273 0.0163
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0021 0.0009
Echinococcus multilocularis dro:myosuppressin receptor 0.0012 0.0021 0.002
Schistosoma mansoni hypothetical protein 0.0012 0.0021 0.0009
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0047 0.0047
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.1256 1 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0012 0.0021 0.0009
Brugia malayi hypothetical protein 0.0012 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0012 0.0012
Echinococcus multilocularis neuropeptide Y receptor 0.0012 0.0021 0.002
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0421 0.3303 0.3303
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0273 0.104
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0273 0.0163
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0012 0.0021 0.002
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0172 0.0171
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0012 0.0012
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0043 0.0273 0.0272
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0012 0.0021 0.0021
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0012 0.0021 0.002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0702 0.0701
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0238 0.183 0.1829
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0021 0.0009
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0109 0.0109
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0012 0.0012
Brugia malayi hypothetical protein 0.0012 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0021 0.002
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0012 0.0021 0.002
Onchocerca volvulus 0.0012 0.0021 0.0164
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0081 0.0574 0.0574
Trichomonas vaginalis PIKK family atypical protein kinase 0.0238 0.183 0.1738
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0109 0.222
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0112 0.0962
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0012 0.0012
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0081 0.0574 0.0468
Loa Loa (eye worm) hypothetical protein 0.0256 0.1978 0.1977
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0081 0.0574 0.0574
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0702 0.0701
Mycobacterium tuberculosis Conserved protein 0.0043 0.0273 0.104
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0012 0.0021 0.0164
Leishmania major phosphatidylinositol kinase, putative 0.0081 0.0574 0.047
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0081 0.0574 0.0574
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0021 0.002
Entamoeba histolytica hypothetical protein 0.0026 0.0131 0.0022
Schistosoma mansoni amine GPCR 0.0012 0.0021 0.0009
Entamoeba histolytica hypothetical protein 0.0081 0.0574 0.047
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0012 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0999 0.7938 0.7915
Schistosoma mansoni ran 0.0023 0.0112 0.01
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Brugia malayi G-protein coupled receptor 0.0012 0.0021 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0012 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.1256 1 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0012 0.0021 0.002
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0131 0.0019
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0421 0.3303 0.3228
Toxoplasma gondii ABC1 family protein 0.0043 0.0273 0.0221
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0238 0.183 0.1821
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0012 0.0021 0.002
Giardia lamblia Hypothetical protein 0.0081 0.0574 0.0468
Schistosoma mansoni biogenic amine (5HT) receptor 0.0012 0.0021 0.0009
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0157 0.118 0.108
Echinococcus multilocularis snurportin 1 0.0339 0.2642 0.2641
Trichomonas vaginalis PIKK family atypical protein kinase 0.0934 0.7418 0.7389
Trichomonas vaginalis PIKK family atypical protein kinase 0.0843 0.6683 0.6645
Loa Loa (eye worm) phosphatidylinositol 3 0.0081 0.0574 0.0574
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0081 0.0574 0.0574
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0021 0.002
Echinococcus multilocularis somatostatin receptor 0.0012 0.0021 0.002
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0081 0.0574 0.0564
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0021 0.002
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0081 0.0574 0.0468
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Schistosoma mansoni biogenic amine receptor 0.0012 0.0021 0.0009
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0081 0.0574 0.047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0934 0.7418 0.7389
Trichomonas vaginalis PIKK family atypical protein kinase 0.0934 0.7418 0.7389
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0081 0.0574 1
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0273 0.4112
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0081 0.0574 0.0574
Echinococcus granulosus g protein coupled receptor 0.0012 0.0021 0.002
Onchocerca volvulus 0.0012 0.0021 0.0164
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.045 0.0439
Brugia malayi Tachykinin-like peptides receptor 99D 0.0012 0.0021 0.0021
Brugia malayi Melatonin receptor type 1A 0.0012 0.0021 0.0021
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0421 0.3303 0.3296
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0021 0.0009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Loa Loa (eye worm) phosphatidylinositol 3 0.0081 0.0574 0.0574
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0273 0.0272
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0112 0.0962
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0273 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0081 0.0574 0.0633
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0394 0.0386
Trichomonas vaginalis PIKK family atypical protein kinase 0.0421 0.3303 0.3228
Echinococcus granulosus tachykinin peptides receptor 99D 0.0012 0.0021 0.002
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0273 0.0163
Brugia malayi follicle stimulating hormone receptor 0.0012 0.0021 0.0021
Onchocerca volvulus 0.0043 0.0273 0.4645
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0273 0.0163
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0081 0.0574 1
Leishmania major phosphatidylinositol kinase related protein, putative 0.0081 0.0574 0.047
Loa Loa (eye worm) phosphatidylinositol kinase 0.0081 0.0574 0.0574
Onchocerca volvulus 0.0012 0.0021 0.0164
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0109 0.0259
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0021 0.002
Echinococcus granulosus g protein coupled receptor 0.0012 0.0021 0.002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0012 0.0011
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0339 0.2642 0.2641
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0081 0.0574 0.0468
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.019 0.019
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0179 0.0178
Giardia lamblia GTOR 0.1256 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Echinococcus granulosus fmrfamide receptor 0.0012 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0265 0.2048 0.1958
Trichomonas vaginalis PIKK family atypical protein kinase 0.0421 0.3303 0.3228
Echinococcus multilocularis serine protein kinase ATM 0.0238 0.183 0.1829
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0238 0.183 0.1829
Echinococcus granulosus geminin 0.0176 0.1338 0.1337
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0109 0.222
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.1256 1 1
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0081 0.0574 0.0574
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0273 0.0272
Schistosoma mansoni cpg binding protein 0.0031 0.0172 0.0161
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0081 0.0574 0.0468
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0012 0.0021 0.0021
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0273 0.0163
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0021 0.002
Onchocerca volvulus 0.0012 0.0021 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0751 0.5945 0.5899
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0238 0.183 0.1738
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0062 0.0036
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Echinococcus granulosus G protein coupled receptor 139 0.0012 0.0021 0.002
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0081 0.0574 0.047
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0081 0.0574 0.0633
Trichomonas vaginalis PIKK family atypical protein kinase 0.0743 0.5885 0.5839
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0574 0.0468
Echinococcus granulosus neuropeptide receptor 0.0012 0.0021 0.002
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0021 0.002
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0081 0.0574 0.0574
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0702 0.0701
Schistosoma mansoni opsin-like receptor 0.0012 0.0021 0.0009
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0081 0.0574 0.047
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.0702 0.0702
Entamoeba histolytica Ran family GTPase 0.0023 0.0112 0.0003
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0081 0.0574 0.0574
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0081 0.0574 0.0468
Schistosoma mansoni opsin-like receptor 0.0012 0.0021 0.0009
Echinococcus granulosus neuropeptide receptor A26 0.0012 0.0021 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.1073 0.8527 0.851
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0012 0.0021 0.0009
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0081 0.0574 0.0564
Schistosoma mansoni opsin-like receptor 0.0012 0.0021 0.0009
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0081 0.0574 0.0574
Schistosoma mansoni hypothetical protein 0.0015 0.0047 0.0036
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0081 0.0574 0.0633
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0081 0.0574 0.0468
Trichomonas vaginalis PIKK family atypical protein kinase 0.0999 0.7938 0.7915
Echinococcus multilocularis fmrfamide receptor 0.0012 0.0021 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0337 0.2628 0.2544
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0011
Schistosoma mansoni hypothetical protein 0.0184 0.1398 0.1388
Trichomonas vaginalis PIKK family atypical protein kinase 0.0934 0.7418 0.7389
Trichomonas vaginalis PIKK family atypical protein kinase 0.0678 0.5365 0.5312
Loa Loa (eye worm) hypothetical protein 0.0184 0.1398 0.1397
Echinococcus granulosus snurportin 1 0.0339 0.2642 0.2641
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0021 0.0009
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0273 0.3521
Schistosoma mansoni myosin xvIII 0.0012 0.0021 0.0009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0702 0.0691
Loa Loa (eye worm) beta-lactamase 0.0043 0.0273 0.0272
Brugia malayi RE15519p 0.0012 0.0021 0.0021
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0081 0.0574 0.0468
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0012 0.0021 0.002
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0179 0.0068
Schistosoma mansoni ran 0.0023 0.0112 0.01
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.2152 1
Leishmania major hypothetical protein, conserved 0.0043 0.0273 0.0166
Echinococcus granulosus cpg binding protein 0.0033 0.0186 0.0185
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0081 0.0574 0.0564
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0021 0.002
Echinococcus multilocularis neuropeptide receptor 0.0012 0.0021 0.002
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0012 0.0012
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0522 0.4109 0.4043
Loa Loa (eye worm) hypothetical protein 0.0043 0.0273 0.0272
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0012 0.0021 0.002
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0109 0.222
Schistosoma mansoni hypothetical protein 0.0012 0.0021 0.0009
Brugia malayi hypothetical protein 0.0012 0.0021 0.0021
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0021 0.0009
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0184 0.1398 0.1397
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.1256 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0421 0.3303 0.3228
Brugia malayi Serotonin receptor 0.0012 0.0021 0.0021
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0081 0.0574 0.0468
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0112 0.0111
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0081 0.0574 0.0468
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0012 0.0021 0.002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0021 0.0009
Onchocerca volvulus 0.0012 0.0021 0.0164
Echinococcus multilocularis serotonin receptor 0.0012 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0033 0.019 0.0189
Onchocerca volvulus 0.0012 0.0021 0.0164
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0012 0.0011
Mycobacterium leprae conserved hypothetical protein 0.0081 0.0574 1
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0047 0.0047
Brugia malayi ecdysteroid receptor 0.0011 0.0012 0.0012
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0081 0.0574 0.0574
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.1256 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.0012 0.0021 0.002
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0081 0.0574 0.0574
Trichomonas vaginalis esterase, putative 0.0043 0.0273 0.0163
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0012 0.0021 0.002
Brugia malayi hypothetical protein 0.0012 0.0021 0.0021
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0047 0.0046
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0112 0.0111
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0131 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0012 0.0012
Schistosoma mansoni biogenic amine (5HT) receptor 0.0012 0.0021 0.0009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Mycobacterium ulcerans beta-lactamase 0.0043 0.0273 1
Brugia malayi sulfakinin receptor protein 0.0012 0.0021 0.0021
Echinococcus multilocularis fmrfamide receptor 0.0012 0.0021 0.002
Brugia malayi hypothetical protein 0.0012 0.0021 0.0021
Loa Loa (eye worm) phosphatidylinositol 3 0.1256 1 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0012 0.0021 0.0009
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0081 0.0574 0.0574
Loa Loa (eye worm) hypothetical protein 0.0017 0.0062 0.0062
Brugia malayi G protein-coupled receptor 0.0012 0.0021 0.0021
Leishmania major importin beta-1 subunit, putative 0.0026 0.0131 0.0022
Onchocerca volvulus 0.0012 0.0021 0.0164
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0012 0.0021 0.0009
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0021 0.002
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0081 0.0574 0.0574
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Brugia malayi beta-lactamase family protein 0.0043 0.0273 0.0273
Brugia malayi beta-lactamase 0.0043 0.0273 0.0273
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0012 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0934 0.7418 0.7389
Brugia malayi neuropeptide F receptor 0.0012 0.0021 0.0021
Schistosoma mansoni amine GPCR 0.0012 0.0021 0.0009
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0012 0.0011
Echinococcus multilocularis neuropeptide FF receptor 2 0.0012 0.0021 0.002
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0081 0.0574 0.0468
Schistosoma mansoni hypothetical protein 0.044 0.3452 0.3444
Echinococcus granulosus serotonin receptor 0.0012 0.0021 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0751 0.5945 0.5899
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0677 0.5357 0.5304
Leishmania major GTP-binding protein, putative 0.0023 0.0112 0.0003
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0012 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0043 0.0273 0.0272
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Echinococcus granulosus 7tm_1 domain containing protein 0.0012 0.0021 0.002
Echinococcus granulosus alpha 1A adrenergic receptor 0.0012 0.0021 0.002
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0265 0.2048 0.2047
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0062 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0184 0.1398 0.13
Brugia malayi hypothetical protein 0.0012 0.0021 0.0021
Brugia malayi nuclear receptor NHR-88 0.0011 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0751 0.5945 0.5899
Onchocerca volvulus 0.0012 0.0021 0.0164
Schistosoma mansoni hypothetical protein 0.0012 0.0021 0.0009
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.1256 1 1
Onchocerca volvulus 0.0012 0.0021 0.0164
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0047 0.0046
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0021 0.002
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.0702 0.0701
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0012 0.0011
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0179 0.0068
Brugia malayi nuclear hormone receptor 0.0011 0.0012 0.0012
Loa Loa (eye worm) neuropeptide F receptor 0.0012 0.0021 0.002
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0012 0.0021 0.002
Brugia malayi Importin beta-1 subunit 0.0032 0.0179 0.0179
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0081 0.0574 0.0633
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.1256 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0021 0.002
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0043 0.0273 0.0272
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0012 0.0021 0.0009
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0273 0.104
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0273 0.104
Loa Loa (eye worm) TYRA-2 protein 0.0012 0.0021 0.002
Mycobacterium tuberculosis Conserved protein 0.0043 0.0273 0.104
Echinococcus granulosus biogenic amine 5HT receptor 0.0012 0.0021 0.002
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0012 0.0012
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0081 0.0574 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Echinococcus granulosus neuropeptide Y receptor 0.0012 0.0021 0.002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0702 0.0691
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0081 0.0574 0.0468
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0081 0.0574 0.0468
Trichomonas vaginalis PIKK family atypical protein kinase 0.0999 0.7938 0.7915
Brugia malayi beta-lactamase family protein 0.0043 0.0273 0.0273
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0109 0.222
Schistosoma mansoni hypothetical protein 0.0081 0.0574 0.0564
Echinococcus multilocularis g-protein coupled receptor 0.0012 0.0021 0.002
Echinococcus granulosus allatostatin A receptor 0.0012 0.0021 0.002
Onchocerca volvulus 0.0031 0.0172 0.2852
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0081 0.0574 0.0564
Schistosoma mansoni neuropeptide receptor 0.0012 0.0021 0.0009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0999 0.7938 0.7915
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0702 0.0691
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0273 1
Schistosoma mansoni histamine h1 receptor 0.0012 0.0021 0.0009
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0012 0.0011
Brugia malayi larval opioid receptor 0.0012 0.0021 0.0021
Brugia malayi ORL1-like opioid receptor 0.0012 0.0021 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0012 0.0012
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0021 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0421 0.3303 0.3228
Echinococcus granulosus somatostatin receptor 0.0012 0.0021 0.002
Onchocerca volvulus 0.0043 0.0273 0.4645
Leishmania major hypothetical protein, unknown function 0.0081 0.0574 0.047
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0081 0.0574 0.0468
Onchocerca volvulus 0.0012 0.0021 0.0164
Echinococcus multilocularis G-protein coupled receptor, putative 0.0012 0.0021 0.002
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.1256 1 1
Plasmodium vivax importin-beta 2, putative 0.0032 0.0179 0.2275
Schistosoma mansoni biogenic amine receptor 0.0012 0.0021 0.0009
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0081 0.0574 0.0574
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0081 0.0574 1
Echinococcus granulosus orexin receptor type 2 0.0012 0.0021 0.002
Onchocerca volvulus 0.0043 0.0273 0.4645
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0012 0.0021 0.002
Echinococcus multilocularis allatostatin A receptor 0.0012 0.0021 0.002
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0012 0.0021 0.002
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0109 0.222
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0081 0.0574 0.0468
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Echinococcus multilocularis Zinc finger, PHD finger 0.0081 0.0574 0.0574
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0011
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0012 0.0021 0.0009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Echinococcus multilocularis neuropeptide s receptor 0.0012 0.0021 0.002
Mycobacterium ulcerans lipase LipD 0.0043 0.0273 1
Schistosoma mansoni biogenic amine receptor 0.0012 0.0021 0.0009
Mycobacterium tuberculosis Conserved hypothetical protein 0.0081 0.0574 0.2477
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0012 0.0021 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.1256 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0081 0.0574 0.047
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0012 0.0021 0.0021
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0012 0.0021 0.0009
Onchocerca volvulus 0.0012 0.0021 0.0164
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0081 0.0574 0.0468
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Echinococcus multilocularis sex peptide receptor 0.0012 0.0021 0.002
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0012 0.0011
Schistosoma mansoni hypothetical protein 0.0339 0.2642 0.2634
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0012 0.0011
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0273 0.0273
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0012 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0081 0.0574 0.0574
Schistosoma mansoni cpg binding protein 0.0033 0.0186 0.0175
Schistosoma mansoni neuropeptide f receptor 76f 0.0012 0.0021 0.0009
Loa Loa (eye worm) hypothetical protein 0.0023 0.0109 0.0108
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0012 0.0021 0.0021
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0021 0.0009
Mycobacterium ulcerans hypothetical protein 0.0043 0.0273 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0012 0.0021 0.0009
Toxoplasma gondii target of rapamycin (TOR), putative 0.0934 0.7418 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Schistosoma mansoni hypothetical protein 0.0176 0.1338 0.1328
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0021 0.002
Loa Loa (eye worm) G-protein coupled receptor 0.0012 0.0021 0.002
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0021 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0677 0.5357 0.5304
Onchocerca volvulus 0.0081 0.0574 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0678 0.5365 0.5312
Brugia malayi CXXC zinc finger family protein 0.0031 0.0172 0.0172
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0081 0.0574 0.0574
Loa Loa (eye worm) hypothetical protein 0.0023 0.0109 0.0108
Brugia malayi hypothetical protein 0.0012 0.0021 0.0021
Leishmania major phosphatidylinositol 3-kinase, putative 0.0421 0.3303 0.3229
Entamoeba histolytica protein kinase rad3, putative 0.0238 0.183 0.174
Loa Loa (eye worm) melatonin receptor type 1A 0.0012 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0017 0.0062 0.0062
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0021 0.002
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0081 0.0574 0.0564
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0047 0.0046
Brugia malayi Dopamine receptor protein 2 0.0012 0.0021 0.0021
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0012 0.0011
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0081 0.0574 0.0574
Echinococcus multilocularis neuropeptide receptor 0.0012 0.0021 0.002
Entamoeba histolytica hypothetical protein 0.0081 0.0574 0.047
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0021 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0238 0.183 0.1738
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.002
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0012 0.0012
Echinococcus granulosus GPCR family 2 0.0015 0.0047 0.0046
Brugia malayi neuropeptide F receptor 0.0012 0.0021 0.0021
Echinococcus granulosus biogenic amine 5HT receptor 0.0012 0.0021 0.002
Echinococcus multilocularis neuropeptide receptor A26 0.0012 0.0021 0.002
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0081 0.0574 1
Echinococcus granulosus sex peptide receptor 0.0012 0.0021 0.002
Echinococcus granulosus neuropeptide FF receptor 2 0.0012 0.0021 0.002
Echinococcus granulosus importin subunit beta 1 0.0032 0.0179 0.0178
Echinococcus granulosus neuropeptide Y receptor 0.0012 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0081 0.0574 0.0574
Mycobacterium ulcerans hypothetical protein 0.0023 0.0109 0.222
Echinococcus granulosus neuropeptides capa receptor 0.0012 0.0021 0.002
Onchocerca volvulus 0.0012 0.0021 0.0164
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0021 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0934 0.7418 0.7389
Loa Loa (eye worm) G-protein coupled receptor 0.0012 0.0021 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.1256 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0012 0.0012
Echinococcus multilocularis geminin 0.0176 0.1338 0.1337
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0012 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0157 0.118 0.1179
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0048 0.0313 0.0312

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 25.38 uM PUBCHEM_BIOASSAY: Identification of SV40 T antigen inhibitors: A route to novel anti-viral reagents. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1909, AID2102, AID2501, AID2615, AID2775, AID449729, AID485276, AID485288] ChEMBL. No reference
IC50 (functional) > 100 uM In vitro cell growth inhibitory activity against K562 human chronic myelogenous leukemia cell line ChEMBL. No reference
IC50 (functional) > 100 uM In vitro cell growth inhibitory activity against K562 human chronic myelogenous leukemia cell line ChEMBL. No reference
Potency (functional) 0.2936 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.4147 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 1.4125 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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