TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 410.425 | Formula: C24H18N4O3
H donors: 1 H acceptors: 4 LogP: 4.27 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CC(C(=O)Nc1ccc2c(c1)nc(o2)c1ncccn1)Oc1cccc2c1cccc2
InChi: 1S/C24H18N4O3/c1-15(30-20-9-4-7-16-6-2-3-8-18(16)20)23(29)27-17-10-11-21-19(14-17)28-24(31-21)22-25-12-5-13-26-22/h2-15H,1H3,(H,27,29)
InChiKey: JEMRJBHXGAQYMP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	IMP (inosine 5'-monophosphate) dehydrogenase 2	Starlite/ChEMBL	References
Cryptosporidium parvum	inosine-5-monophosphate dehydrogenase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania infantum	inosine-5-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Plasmodium falciparum	inosine-5'-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD)	Get druggable targets OG5_126887	All targets in OG5_126887
Schistosoma japonicum	ko:K00088 IMP dehydrogenase [EC1.1.1.205], putative	Get druggable targets OG5_126887	All targets in OG5_126887
Mycobacterium ulcerans	inosine 5'-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania braziliensis	guanosine monophosphate reductase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Babesia bovis	inosine-5'-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Plasmodium vivax	inosine-5'-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Brugia malayi	inosine-5'-monophosphate dehydrogenase family protein	Get druggable targets OG5_126887	All targets in OG5_126887
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Cryptosporidium hominis	inosine-5-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Loa Loa (eye worm)	IMP dehydrogenase 1	Get druggable targets OG5_126887	All targets in OG5_126887
Candida albicans	N terminus of Inosine-5'-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Cryptosporidium parvum	inosine-5-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Candida albicans	guanosine nucleotide biosynthesis	Get druggable targets OG5_126887	All targets in OG5_126887
Candida albicans	guanosine nucleotide biosynthesis	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma brucei	GMP reductase	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania donovani	inosine-5'-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Mycobacterium ulcerans	inosine 5-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma brucei gambiense	inosine-5-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma brucei	inosine-5'-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania mexicana	guanosine monophosphate reductase	Get druggable targets OG5_126887	All targets in OG5_126887
Echinococcus multilocularis	inosine 5' monophosphate dehydrogenase 2	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania braziliensis	inosine-5-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma cruzi	GMP reductase	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania major	guanosine monophosphate reductase	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma congolense	GMP reductase	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania major	inosine-5-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma cruzi	GMP reductase	Get druggable targets OG5_126887	All targets in OG5_126887
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania infantum	guanosine monophosphate reductase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania mexicana	inosine-5-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Theileria parva	Inosine-5'-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Plasmodium yoelii	inosine-5'-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania donovani	GMP reductase	Get druggable targets OG5_126887	All targets in OG5_126887
Plasmodium berghei	inosine-5'-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Schistosoma mansoni	inosine-5-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Plasmodium knowlesi	inosine-5'-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Echinococcus granulosus	inosine 5' monophosphate dehydrogenase 2	Get druggable targets OG5_126887	All targets in OG5_126887
Wolbachia endosymbiont of Brugia malayi	IMP dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma brucei gambiense	inosine-5-monophosphate dehydrogenase,IMP dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Neospora caninum	hypothetical protein	Get druggable targets OG5_126887	All targets in OG5_126887
Toxoplasma gondii	IMP dehydrogenas	Get druggable targets OG5_126887	All targets in OG5_126887
Candida albicans	N terminus of Inosine-5'-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	PHD-finger domain-containing protein	0.0048	0.0449	0.1534
Loa Loa (eye worm)	hypothetical protein	0.002	0.0066	0.0226
Leishmania major	pyruvate kinase	0.0029	0.0188	0.0641
Trichomonas vaginalis	set domain proteins, putative	0.0171	0.2137	0.1987
Mycobacterium ulcerans	beta-lactamase	0.0032	0.0219	0.0069
Echinococcus granulosus	geminin	0.0292	0.3798	1
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0029	0.0189	0.0002
Plasmodium vivax	hypothetical protein, conserved	0.0032	0.0219	0.0771
Trypanosoma cruzi	hypothetical protein, conserved	0.0032	0.0219	0.075
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0032	0.0219	0.0069
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.0016	0.0003	0.0009
Schistosoma mansoni	hypothetical protein	0.0029	0.0183	0.0482
Onchocerca volvulus		0.0079	0.0869	0.3777
Trypanosoma brucei	inosine-5'-monophosphate dehydrogenase	0.0228	0.2924	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0124	0.1489	0.5091
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0183	0.0626
Schistosoma mansoni	cpg binding protein	0.0025	0.0136	0.0358
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0032	0.0227	0.0041
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.015	0.1853	0.6335
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0022	0.0088	0.0233
Echinococcus multilocularis	Chromobox protein 3	0.0029	0.0189	0.0499
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0044	0.0395	0.104
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD)	0.0228	0.2924	0.5965
Trypanosoma cruzi	GMP reductase	0.0228	0.2924	1
Entamoeba histolytica	hypothetical protein	0.0029	0.0189	0.0124
Loa Loa (eye worm)	helicase	0.0029	0.0189	0.0648
Echinococcus granulosus	chromobox protein 2	0.0029	0.0189	0.0499
Echinococcus multilocularis	Chromo domain	0.0029	0.0189	0.0499
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0035	0.026	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0219	0.075
Echinococcus granulosus	lysine specific demethylase 5A	0.0061	0.0625	0.1645
Plasmodium vivax	SET domain protein, putative	0.0022	0.0088	0.0311
Brugia malayi	AF-10 protein	0.0016	0.0003	0.0009
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0029	0.0189	0.0002
Echinococcus granulosus	jumonji domain containing protein	0.0067	0.0708	0.1864
Echinococcus multilocularis	chromobox protein 1	0.0179	0.225	0.5924
Mycobacterium leprae	Probable lipase LipE	0.0032	0.0219	0.0069
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0124	0.1489	0.392
Toxoplasma gondii	ABC1 family protein	0.0032	0.0219	0.075
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0922	0.3152
Mycobacterium tuberculosis	Probable esterase LipL	0.0032	0.0219	0.0069
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0018	0.0027	0.0072
Schistosoma mansoni	bromodomain containing protein	0.0047	0.043	0.1133
Brugia malayi	PHD-finger family protein	0.0019	0.0051	0.0173
Schistosoma mansoni	hypothetical protein	0.0048	0.0449	0.1181
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0026	0.0142	0.0373
Plasmodium vivax	pyruvate kinase, putative	0.0029	0.0188	0.0659
Brugia malayi	inosine-5'-monophosphate dehydrogenase	0.0098	0.1138	0.3893
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0219	0.075
Trichomonas vaginalis	esterase, putative	0.0032	0.0219	0.0032
Trypanosoma brucei	GMP reductase	0.0228	0.2924	1
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0029	0.0188	0.0641
Onchocerca volvulus		0.0032	0.0219	0.059
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0021	0.0071	0.0186
Schistosoma mansoni	hypothetical protein	0.0292	0.3798	1
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0046	0.0413	0.1413
Plasmodium falciparum	pyruvate kinase	0.0029	0.0188	0.0659
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0189	0.0648
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0189	0.0002
Mycobacterium tuberculosis	Probable hydrolase	0.0032	0.0219	0.0069
Trichomonas vaginalis	D-aminoacylase, putative	0.0032	0.0219	0.0032
Echinococcus multilocularis	inosine 5' monophosphate dehydrogenase 2	0.0228	0.2924	0.77
Echinococcus multilocularis	pyruvate kinase	0.0029	0.0188	0.0494
Schistosoma mansoni	chromobox protein	0.0029	0.0189	0.0499
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0035	0.026	0.0074
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0744	1	1
Brugia malayi	PHD-finger family protein	0.0018	0.0039	0.0135
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0744	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0189	0.0002
Brugia malayi	jmjC domain containing protein	0.0061	0.0625	0.2136
Echinococcus granulosus	inosine 5' monophosphate dehydrogenase 2	0.0228	0.2924	0.77
Brugia malayi	Heterochromatin protein 1	0.0179	0.225	0.7693
Mycobacterium ulcerans	inosine 5-monophosphate dehydrogenase	0.0223	0.2847	0.5796
Toxoplasma gondii	PHD-finger domain-containing protein	0.0048	0.0449	0.1534
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0032	0.0219	0.0578
Schistosoma mansoni	cpg binding protein	0.0023	0.0099	0.0261
Wolbachia endosymbiont of Brugia malayi	IMP dehydrogenase	0.0228	0.2924	0.5
Brugia malayi	Bromodomain containing protein	0.005	0.0472	0.1614
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0018	0.0037	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0869	0.2971
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0744	1	1
Brugia malayi	M-phase phosphoprotein, mpp8	0.0029	0.0189	0.0648
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0367	0.1254
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0029	0.0189	0.0124
Brugia malayi	inosine-5'-monophosphate dehydrogenase family protein	0.0228	0.2924	1
Echinococcus granulosus	chromobox protein 1	0.0179	0.225	0.5924
Schistosoma mansoni	chromobox protein	0.0179	0.225	0.5924
Plasmodium vivax	hypothetical protein, conserved	0.0048	0.0449	0.1575
Toxoplasma gondii	IMP dehydrogenas	0.0228	0.2924	1
Plasmodium falciparum	conserved Plasmodium membrane protein, unknown function	0.0017	0.0022	0.0076
Echinococcus granulosus	cpg binding protein	0.0025	0.0136	0.0358
Plasmodium vivax	hypothetical protein, conserved	0.0029	0.0189	0.0665
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0032	0.0219	0.075
Brugia malayi	latrophilin 2 splice variant baaae	0.0029	0.0183	0.0626
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0034	0.0257	0.0677
Trichomonas vaginalis	penicillin-binding protein, putative	0.0032	0.0219	0.0032
Onchocerca volvulus	Putative GMP reductase	0.0098	0.1138	0.51
Echinococcus multilocularis	chromodomain helicase DNA binding protein 1	0.0029	0.0189	0.0499
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0124	0.1489	0.392
Trypanosoma cruzi	hypothetical protein, conserved	0.0032	0.0219	0.075
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0032	0.0222	0.0035
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0029	0.0189	0.0002
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0018	0.0037	0.0097
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0048	0.0449	0.1181
Loa Loa (eye worm)	CHromoDomain protein family member	0.0032	0.0226	0.0773
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0032	0.0219	0.0069
Toxoplasma gondii	'chromo' (CHRromatin Organization MOdifier) domain-containing protein	0.0029	0.0189	0.0648
Trypanosoma brucei	hypothetical protein, conserved	0.0032	0.0219	0.075
Mycobacterium ulcerans	hypothetical protein	0.0032	0.0219	0.0069
Mycobacterium tuberculosis	Conserved protein	0.0032	0.0219	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0039	0.0135
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0257	0.0677
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0363	0.4776	1
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1167	0.3991
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0449	0.1534
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0035	0.026	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0189	0.0648
Mycobacterium tuberculosis	Conserved protein	0.0032	0.0219	0.0069
Trichomonas vaginalis	chromobox protein, putative	0.0108	0.1272	0.1105
Loa Loa (eye worm)	PHD-finger family protein	0.0048	0.0449	0.1534
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0049	0.0461	0.1213
Echinococcus multilocularis	pyruvate kinase	0.0023	0.0103	0.0271
Schistosoma mansoni	hypothetical protein	0.0016	0.0003	0.0007
Echinococcus granulosus	histone lysine methyltransferase setb	0.0034	0.0257	0.0677
Trichomonas vaginalis	chromobox protein, putative	0.0179	0.225	0.2102
Echinococcus granulosus	pyruvate kinase	0.0029	0.0188	0.0494
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0166	0.0567
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0189	0.0002
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0023	0.0099	0.0339
Echinococcus granulosus	chromobox protein 1	0.0179	0.225	0.5924
Schistosoma mansoni	chromobox protein	0.0029	0.0189	0.0499
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0032	0.0219	0.0578
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0032	0.0219	0.0069
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0029	0.0189	0.0499
Trypanosoma brucei	pyruvate kinase 1	0.0029	0.0188	0.0641
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0022	0.0088	0.0303
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0189	0.0648
Trichomonas vaginalis	Heterochromatin protein, putative	0.0029	0.0189	0.0002
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0018	0.0027	0.0072
Trichomonas vaginalis	chromobox protein, putative	0.0029	0.0189	0.0002
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0228	0.2924	1
Treponema pallidum	fructose-bisphosphate aldolase	0.0744	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0219	0.075
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0051	0.0492	0.1295
Brugia malayi	Type III restriction enzyme, res subunit family protein	0.0029	0.0189	0.0648
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0189	0.0648
Echinococcus granulosus	pyruvate kinase	0.0029	0.0188	0.0494
Echinococcus multilocularis	jumonji domain containing protein	0.0067	0.0708	0.1864
Loa Loa (eye worm)	beta-lactamase	0.0032	0.0219	0.075
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0032	0.0226	0.0596
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0158	0.1955	0.5149
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0228	0.2924	1
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0363	0.4776	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0124	0.1489	0.5091
Echinococcus granulosus	peregrin	0.005	0.0472	0.1243
Brugia malayi	SET domain containing protein	0.0031	0.0207	0.0708
Toxoplasma gondii	'chromo' (CHRromatin Organization MOdifier) domain-containing protein	0.0029	0.0189	0.0648
Brugia malayi	PHD-finger family protein	0.0048	0.0449	0.1534
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0201	0.2553	0.5157
Mycobacterium leprae	conserved hypothetical protein	0.0032	0.0219	0.0069
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0029	0.0188	0.0641
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0189	0.0002
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0035	0.026	0.0074
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0042	0.0367	0.1254
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0029	0.0188	0.0641
Echinococcus granulosus	Chromo domain	0.0029	0.0189	0.0499
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0022	0.0091	0.024
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0189	0.0002
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0032	0.0226	0.0596
Leishmania major	guanosine monophosphate reductase	0.0228	0.2924	1
Plasmodium vivax	heterochromatin protein 1, putative	0.0029	0.0189	0.0665
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0124	0.1489	0.392
Schistosoma mansoni	cpg binding protein	0.0025	0.0136	0.0358
Brugia malayi	Bromodomain containing protein	0.0055	0.0546	0.1868
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0029	0.0189	0.0124
Onchocerca volvulus		0.0029	0.0189	0.0443
Trichomonas vaginalis	conserved hypothetical protein	0.0101	0.1167	0.0998
Chlamydia trachomatis	pyruvate kinase	0.0029	0.0188	0.5
Plasmodium falciparum	phd finger protein, putative	0.0048	0.0449	0.1575
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0044	0.0395	0.104
Onchocerca volvulus	Pyruvate kinase homolog	0.0029	0.0188	0.0434
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0124	0.1489	0.392
Brugia malayi	hypothetical protein	0.0029	0.0189	0.0648
Onchocerca volvulus	Pyruvate kinase homolog	0.0029	0.0188	0.0434
Onchocerca volvulus		0.0051	0.0492	0.1926
Mycobacterium ulcerans	inosine 5-monophosphate dehydrogenase	0.0104	0.1216	0.2241
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0108	0.1272	0.5755
Loa Loa (eye worm)	jmjC domain-containing protein	0.0061	0.0625	0.2136
Echinococcus multilocularis	chromobox protein 1	0.0179	0.225	0.5924
Plasmodium vivax	inosine-5'-monophosphate dehydrogenase, putative	0.0223	0.2847	1
Onchocerca volvulus		0.0171	0.2137	1
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0029	0.0189	0.0499
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0032	0.0219	0.0069
Plasmodium falciparum	inosine-5'-monophosphate dehydrogenase	0.0223	0.2847	1
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.0764	0.0587
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0029	0.0189	0.0665
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0042	0.0367	0.1254
Brugia malayi	CHD4 protein	0.0032	0.0226	0.0773
Onchocerca volvulus		0.0032	0.0219	0.059
Echinococcus granulosus	beta LACTamase domain containing family member	0.0032	0.0219	0.0578
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0228	0.2924	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.01	0.1154	0.3945
Brugia malayi	jmjC domain containing protein	0.0158	0.1955	0.6687
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0189	0.0648
Trypanosoma cruzi	GMP reductase	0.0228	0.2924	1
Loa Loa (eye worm)	pyruvate kinase-PB	0.002	0.0066	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0189	0.0648
Echinococcus granulosus	Chromobox protein 3	0.0029	0.0189	0.0499
Brugia malayi	beta-lactamase	0.0032	0.0219	0.075
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0032	0.0226	0.0596
Onchocerca volvulus	Pyruvate kinase homolog	0.0029	0.0188	0.0434
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0101	0.1167	0.524
Brugia malayi	inosine-5'-monophosphate dehydrogenase	0.0098	0.1138	0.3893
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0744	1	1
Brugia malayi	Bromodomain containing protein	0.0028	0.0165	0.0565
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0744	1	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0257	0.0677
Schistosoma mansoni	pyruvate kinase	0.0029	0.0188	0.0494
Trichomonas vaginalis	penicillin-binding protein, putative	0.0032	0.0219	0.0032
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0035	0.026	0.0074
Trichomonas vaginalis	hypothetical protein	0.0029	0.0189	0.0002
Trichomonas vaginalis	chromobox protein, putative	0.0029	0.0189	0.0002
Entamoeba histolytica	hypothetical protein	0.0029	0.0189	0.0124
Onchocerca volvulus		0.0032	0.0219	0.059
Trichomonas vaginalis	D-aminoacylase, putative	0.0032	0.0219	0.0032
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0048	0.0449	0.1181
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0189	0.0002
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0032	0.0219	0.0578
Toxoplasma gondii	chromodomain helicase DNA binding protein CHD1/SWI2/SNF2	0.0029	0.0189	0.0648
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0219	0.075
Echinococcus multilocularis	geminin	0.0292	0.3798	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0124	0.1489	0.392
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0042	0.0367	0.1254
Echinococcus multilocularis	pyruvate kinase	0.0029	0.0188	0.0494
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	0.0228	0.2924	0.5965
Leishmania major	inosine-5-monophosphate dehydrogenase	0.0228	0.2924	1
Brugia malayi	Protein cec-1.	0.0029	0.0189	0.0648
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0744	1	1
Trypanosoma brucei	pyruvate kinase 1, putative	0.0029	0.0188	0.0641
Loa Loa (eye worm)	GMP reductase	0.0098	0.1138	0.3893
Trichomonas vaginalis	chromobox protein, putative	0.0179	0.225	0.2102
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0227	0.0041
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0061	0.0625	0.1645
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena	0.0124	0.1495	0.2849
Loa Loa (eye worm)	pyruvate kinase	0.0029	0.0188	0.0641
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0029	0.0189	0.0499
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0189	0.0648
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0486	0.1662
Mycobacterium ulcerans	lipase LipD	0.0032	0.0219	0.0069
Loa Loa (eye worm)	heterochromatin protein 1	0.0179	0.225	0.7693
Schistosoma mansoni	hypothetical protein	0.0029	0.0189	0.0499
Brugia malayi	beta-lactamase family protein	0.0032	0.0219	0.075
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.0764	0.0587
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0363	0.4776	1
Brugia malayi	GMP reductase	0.0098	0.1138	0.3893
Plasmodium falciparum	chromodomain-helicase-DNA-binding protein 1 homolog, putative	0.0029	0.0189	0.0665
Schistosoma mansoni	inosine-5-monophosphate dehydrogenase	0.0228	0.2924	0.77
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0029	0.0188	0.0641
Echinococcus multilocularis	chromobox protein 2	0.0029	0.0189	0.0499
Leishmania major	pyruvate kinase	0.0029	0.0188	0.0641
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0124	0.1489	0.392
Plasmodium vivax	hypothetical protein, conserved	0.0017	0.0022	0.0076
Echinococcus granulosus	PHD finger protein rhinoceros	0.0048	0.0449	0.1181
Mycobacterium tuberculosis	Conserved protein	0.0032	0.0219	0.0069
Brugia malayi	F/Y-rich N-terminus family protein	0.0025	0.0128	0.0438
Echinococcus granulosus	chromodomain helicase DNA binding protein 1	0.0029	0.0189	0.0499
Giardia lamblia	PHD finger protein 15	0.0048	0.0449	0.0266
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0035	0.026	0.0074
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0189	0.0002
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0026	0.0142	0.0373
Mycobacterium leprae	PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD)	0.0104	0.1216	0.2241
Brugia malayi	Valyl-tRNA synthetase	0.0029	0.0189	0.0648
Plasmodium vivax	hypothetical protein, conserved	0.0029	0.0189	0.0665
Schistosoma mansoni	pyruvate kinase	0.0029	0.0188	0.0494
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0257	0.088
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	0.0124	0.1495	0.2849
Brugia malayi	CXXC zinc finger family protein	0.0023	0.0099	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0188	0.0641
Schistosoma mansoni	hypothetical protein	0.0292	0.3798	1
Mycobacterium tuberculosis	Probable lipase LipE	0.0032	0.0219	0.0069
Onchocerca volvulus		0.0029	0.0189	0.0443
Trichomonas vaginalis	conserved hypothetical protein	0.0101	0.1167	0.0998
Trichomonas vaginalis	chromobox protein, putative	0.0108	0.1272	0.1105
Entamoeba histolytica	hypothetical protein	0.0029	0.0189	0.0124
Schistosoma mansoni	chromobox protein	0.0179	0.225	0.5924
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0219	0.075
Mycobacterium ulcerans	inosine 5'-monophosphate dehydrogenase	0.0228	0.2924	0.5965
Trichomonas vaginalis	D-aminoacylase, putative	0.0032	0.0219	0.0032
Loa Loa (eye worm)	pyruvate kinase	0.0029	0.0188	0.0641
Toxoplasma gondii	WD domain, G-beta repeat-containing protein	0.0016	0.0003	0.0009
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0061	0.0625	0.1645
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0158	0.1955	0.5149
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.0016	0.0003	0.0009
Giardia lamblia	Fructose-bisphosphate aldolase	0.0744	1	1
Trichomonas vaginalis	chromobox protein, putative	0.0029	0.0189	0.0002
Echinococcus granulosus	fetal alzheimer antigen falz	0.0018	0.0027	0.0072
Brugia malayi	chromobox protein homolog 3	0.0101	0.1167	0.3991
Echinococcus multilocularis	peregrin	0.005	0.0472	0.1243
Plasmodium falciparum	heterochromatin protein 1	0.0029	0.0189	0.0665
Echinococcus multilocularis	cpg binding protein	0.0025	0.0136	0.0358
Onchocerca volvulus	Alhambra homolog	0.0048	0.0449	0.1714
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0124	0.1489	0.392
Brugia malayi	Associated with TFs and helicases family protein	0.0029	0.0189	0.0648
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0219	0.075
Loa Loa (eye worm)	IMP dehydrogenase 1	0.0228	0.2924	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0035	0.026	0.0074
Schistosoma mansoni	jumonji domain containing protein	0.0125	0.1509	0.3975
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0032	0.0219	0.075
Mycobacterium ulcerans	esterase/lipase LipP	0.0032	0.0219	0.0069
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0744	1	1
Loa Loa (eye worm)	pyruvate kinase	0.0029	0.0188	0.0641
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0022	0.0088	0.0233
Echinococcus multilocularis	lysine specific demethylase 5A	0.0058	0.0588	0.1548
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0035	0.026	0.0074
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0744	1	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0226	0.0773
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0189	0.0002
Toxoplasma gondii	PHD-finger domain-containing protein	0.0016	0.0003	0.0009
Brugia malayi	Pre-SET motif family protein	0.0022	0.0088	0.0303
Toxoplasma gondii	pyruvate kinase PyK1	0.0029	0.0188	0.0641
Brugia malayi	Pre-SET motif family protein	0.015	0.1853	0.6335
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0189	0.0648
Brugia malayi	beta-lactamase family protein	0.0032	0.0219	0.075
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0744	1	1
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0029	0.0189	0.0124
Leishmania major	hypothetical protein, conserved	0.0032	0.0219	0.075
Mycobacterium tuberculosis	Probable lipase LipD	0.0032	0.0219	0.0069

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)		Inhibition of Cryptosporidium parvum N-terminal His6-tagged IMPDH-mediated NADH production expressed in Escherichia coli BL21(DE3) preincubated for 5 mins prior to substrate addition by fluorescence assay in presence of BSA	ChEMBL.	23668331
IC50 (binding)	> 5000 nM	Inhibition of Cryptosporidium parvum N-terminal His6-tagged IMPDH-mediated NADH production expressed in Escherichia coli BL21(DE3) preincubated for 5 mins prior to substrate addition by fluorescence assay	ChEMBL.	23668331
IC50 (binding)	> 5 uM	Inhibition of human IMPDH2	ChEMBL.	23668331

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2348808

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1756909