Detailed information for compound 1762374

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 316.395 | Formula: C18H24N2O3
  • H donors: 1 H acceptors: 2 LogP: 3.07 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(c1ccc(cc1)OCCCCCn1ccc(=O)[nH]c1=O)C
  • InChi: 1S/C18H24N2O3/c1-14(2)15-6-8-16(9-7-15)23-13-5-3-4-11-20-12-10-17(21)19-18(20)22/h6-10,12,14H,3-5,11,13H2,1-2H3,(H,19,21,22)
  • InChiKey: WHTGOQGVJMWYJM-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) calcium channel 0.0101 0.0322 0.0631
Echinococcus multilocularis voltage dependent calcium channel 0.0101 0.0322 0.0784
Trypanosoma brucei C-8 sterol isomerase, putative 0.0368 0.1628 1
Echinococcus multilocularis transient receptor potential cation channel 0.0101 0.0322 0.0784
Brugia malayi SWIRM domain containing protein 0.0062 0.0134 0.0303
Echinococcus multilocularis transient receptor potential gamma protein 0.0101 0.0322 0.0784
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0343 0.0338
Brugia malayi amine oxidase, flavin-containing family protein 0.0348 0.1532 0.3475
Echinococcus granulosus short transient receptor potential channel 6 0.0101 0.0322 0.0784
Plasmodium vivax amine transporter, putative 0.0081 0.0225 0.1459
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0101 0.0322 0.0784
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0047 0.0114
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0286 0.1226 1
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0101 0.0322 0.0784
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0286 0.1226 1
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0101 0.0322 0.073
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0873 0.4102 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0101 0.0322 0.0784
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.04 0.0405
Echinococcus granulosus TRP transient receptor potential channel 0.0101 0.0322 0.0784
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0047 0.0106
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0343 0.0338
Echinococcus multilocularis sodium channel protein 0.0101 0.0322 0.0784
Brugia malayi hypothetical protein 0.0081 0.0225 0.0511
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0286 0.1226 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0101 0.0322 0.0784
Echinococcus multilocularis sodium and chloride dependent glycine 0.0081 0.0225 0.0549
Schistosoma mansoni voltage-gated potassium channel 0.0101 0.0322 0.0784
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0368 0.1628 0.3694
Schistosoma mansoni vesicular amine transporter 0.0101 0.0323 0.0786
Plasmodium falciparum transporter, putative 0.0081 0.0225 0.1459
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0081 0.0225 0.0549
Echinococcus granulosus transient receptor potential cation channel 0.0101 0.0322 0.0784
Onchocerca volvulus 0.0936 0.4408 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0101 0.0322 0.0784
Brugia malayi cation channel family protein 0.0101 0.0322 0.073
Toxoplasma gondii histone lysine-specific demethylase 0.0286 0.1226 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0101 0.0322 0.073
Brugia malayi hypothetical protein 0.0286 0.1226 0.2783
Loa Loa (eye worm) hypothetical protein 0.0101 0.0322 0.0631
Loa Loa (eye worm) hypothetical protein 0.0081 0.0225 0.0409
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0101 0.0322 0.0784
Echinococcus multilocularis voltage gated potassium channel 0.0101 0.0322 0.0784
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0101 0.0322 0.17
Loa Loa (eye worm) hypothetical protein 0.0101 0.0322 0.0631
Trypanosoma cruzi UDP-galactopyranose mutase 0.0286 0.1226 0.7449
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0286 0.1226 1
Onchocerca volvulus CoRest homolog 0.0198 0.0798 0.1371
Echinococcus granulosus potassium large conductance calcium activated 0.0101 0.0322 0.0784
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0081 0.0225 0.0549
Echinococcus multilocularis ryanodine receptor 44f 0.0101 0.0322 0.0784
Loa Loa (eye worm) ion channel NompC 0.0101 0.0322 0.0631
Schistosoma mansoni voltage-gated ion channel 0.0101 0.0322 0.0784
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0081 0.0225 0.0549
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0101 0.0322 0.0784
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0081 0.0225 0.0549
Loa Loa (eye worm) norepinephrine transporter 0.0477 0.2165 0.4857
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0101 0.0322 0.0784
Brugia malayi hypothetical protein 0.0101 0.0322 0.073
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0101 0.0322 0.073
Loa Loa (eye worm) hypothetical protein 0.0101 0.0322 0.0631
Echinococcus granulosus transient receptor potential cation channel 0.0101 0.0322 0.0784
Echinococcus granulosus synaptic vesicular amine transporter 0.0184 0.0727 0.1772
Loa Loa (eye worm) hypothetical protein 0.0101 0.0322 0.0631
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0101 0.0322 0.0784
Schistosoma mansoni 60S ribosomal protein L21 0.0101 0.0322 0.0784
Echinococcus multilocularis transfer RNA-Gly 0.0101 0.0322 0.0784
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0286 0.1226 0.299
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0101 0.0322 0.0784
Echinococcus granulosus hypothetical protein 0.0101 0.0322 0.0784
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0047 0.0114
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0101 0.0322 0.0784
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0101 0.0322 0.0784
Echinococcus granulosus voltage dependent calcium channel 0.0101 0.0322 0.0784
Schistosoma mansoni hypothetical protein 0.0101 0.0322 0.0784
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.1793 0.8602 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0225 0.0409
Onchocerca volvulus 0.0101 0.0322 0.0231
Echinococcus granulosus two pore calcium channel protein 2 0.0101 0.0322 0.0784
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0101 0.0322 0.073
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0081 0.0225 0.0511
Loa Loa (eye worm) hypothetical protein 0.0198 0.0798 0.1724
Plasmodium falciparum protoporphyrinogen oxidase 0.0286 0.1226 1
Brugia malayi ion channel NompC 0.0101 0.0322 0.073
Giardia lamblia hypothetical protein 0.0062 0.0134 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0101 0.0322 0.0784
Toxoplasma gondii transporter, cation channel family protein 0.0101 0.0322 0.2283
Loa Loa (eye worm) hypothetical protein 0.0101 0.0322 0.0631
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0101 0.0322 0.0784
Leishmania major hypothetical protein, unknown function 0.0101 0.0322 0.17
Loa Loa (eye worm) hypothetical protein 0.0062 0.0134 0.02
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0101 0.0322 0.073
Echinococcus multilocularis serotonin transporter 0.0477 0.2165 0.5277
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0081 0.0225 0.0549
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0081 0.0225 0.0549
Schistosoma mansoni sodium-dependent amino acid transporter 0.0081 0.0225 0.0549
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0101 0.0322 0.0784
Echinococcus multilocularis potassium voltage gated channel protein 0.0101 0.0322 0.0784
Schistosoma mansoni voltage-gated cation channel 0.0101 0.0322 0.0784
Loa Loa (eye worm) solute carrier family 6 member 4 0.0477 0.2165 0.4857
Schistosoma mansoni voltage-dependent calcium channel 0.0101 0.0322 0.0784
Toxoplasma gondii hypothetical protein 0.0101 0.0322 0.2283
Schistosoma mansoni sodium/chloride dependent transporter 0.0081 0.0225 0.0549
Loa Loa (eye worm) hypothetical protein 0.0101 0.0322 0.0631
Loa Loa (eye worm) hypothetical protein 0.0101 0.0322 0.0631
Echinococcus granulosus voltage gated potassium channel 0.0101 0.0322 0.0784
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0286 0.1226 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0047 0.0114
Echinococcus multilocularis transient receptor potential cation channel 0.0101 0.0322 0.0784
Echinococcus multilocularis calcium activated potassium channel 0.0101 0.0322 0.0784
Entamoeba histolytica SWIRM domain protein 0.0062 0.0134 1
Loa Loa (eye worm) MH2 domain-containing protein 0.014 0.0514 0.1072
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0101 0.0322 0.0784
Loa Loa (eye worm) hypothetical protein 0.0081 0.0225 0.0409
Brugia malayi glutathione reductase 0.0046 0.0054 0.0122
Schistosoma mansoni sodium/chloride dependent transporter 0.0477 0.2165 0.5277
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0101 0.0322 0.0784
Brugia malayi cation channel family protein 0.0101 0.0322 0.073
Loa Loa (eye worm) voltage-gated potassium channel 0.0101 0.0322 0.0631
Schistosoma mansoni voltage-gated potassium channel 0.0101 0.0322 0.0784
Echinococcus multilocularis hyperpolarization activated cyclic 0.0101 0.0322 0.0784
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0101 0.0322 0.2283
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0477 0.2165 0.4912
Echinococcus granulosus hyperpolarization activated cyclic 0.0101 0.0322 0.0784
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0101 0.0322 0.0784
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0101 0.0322 0.0784
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0101 0.0322 0.0784
Loa Loa (eye worm) hypothetical protein 0.0101 0.0322 0.0631
Echinococcus multilocularis potassium voltage gated channel protein 0.0101 0.0322 0.0784
Loa Loa (eye worm) voltage-gated calcium channel 0.0101 0.0322 0.0631
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.04 0.0405
Schistosoma mansoni microtubule-associated protein tau 0.081 0.3791 0.924
Brugia malayi Myb-like DNA-binding domain containing protein 0.0193 0.0771 0.1749
Toxoplasma gondii hypothetical protein 0.0081 0.0225 0.1459
Schistosoma mansoni sodium/chloride dependent transporter 0.0081 0.0225 0.0549
Loa Loa (eye worm) hypothetical protein 0.0101 0.0322 0.0631
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0101 0.0322 0.0784
Loa Loa (eye worm) voltage-gated potassium channel 0.0101 0.0322 0.0631
Echinococcus granulosus short transient receptor potential channel 6 0.0101 0.0322 0.0784
Treponema pallidum sodium- and chloride- dependent transporter 0.0477 0.2165 0.5
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0368 0.1628 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0225 0.0409
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0047 0.0114
Echinococcus granulosus sodium channel protein 0.0101 0.0322 0.0784
Loa Loa (eye worm) hypothetical protein 0.0101 0.0322 0.0631
Trypanosoma cruzi UDP-galactopyranose mutase 0.0286 0.1226 0.7449
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0081 0.0225 0.0511
Echinococcus granulosus potassium voltage gated channel protein 0.0101 0.0322 0.0784
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0101 0.0322 0.0784
Entamoeba histolytica hypothetical protein 0.0062 0.0134 1
Echinococcus multilocularis conserved hypothetical protein 0.0101 0.0322 0.0784
Schistosoma mansoni voltage-gated potassium channel 0.0101 0.0322 0.0784
Echinococcus multilocularis two pore calcium channel protein 1 0.0101 0.0322 0.0784
Echinococcus granulosus potassium voltage gated channel protein 0.0101 0.0322 0.0784
Toxoplasma gondii hypothetical protein 0.0101 0.0322 0.2283
Echinococcus granulosus sodium and chloride dependent glycine 0.0081 0.0225 0.0549
Echinococcus multilocularis hyperpolarization activated cyclic 0.0101 0.0322 0.0784
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0343 0.0338
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0101 0.0322 1
Echinococcus multilocularis voltage dependent calcium channel 0.0101 0.0322 0.0784
Leishmania major UDP-galactopyranose mutase 0.0286 0.1226 0.7449
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0101 0.0322 0.0631
Loa Loa (eye worm) hypothetical protein 0.0477 0.2165 0.4857
Loa Loa (eye worm) hypothetical protein 0.0101 0.0322 0.0631
Schistosoma mansoni voltage-gated potassium channel 0.0101 0.0322 0.0784
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0101 0.0322 0.0784
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.04 0.0405
Schistosoma mansoni voltage-gated potassium channel 0.0101 0.0322 0.0784
Loa Loa (eye worm) abnormal catecholamine distribution protein 1 0.0184 0.0727 0.156
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0101 0.0322 0.0784
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0101 0.0322 0.0784
Echinococcus granulosus lysine specific histone demethylase 1A 0.0286 0.1226 0.299
Brugia malayi Cyclic-nucleotide gated cation channel 0.0101 0.0322 0.073
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0101 0.0322 0.0231
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0062 0.0134 0.0326
Echinococcus granulosus voltage gated potassium channel 0.0101 0.0322 0.0784
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0101 0.0322 0.073
Loa Loa (eye worm) hypothetical protein 0.0081 0.0225 0.0409
Toxoplasma gondii transporter, cation channel family protein 0.0101 0.0322 0.2283
Loa Loa (eye worm) hypothetical protein 0.0368 0.1628 0.3626
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0101 0.0322 0.0784
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0101 0.0322 0.0784
Loa Loa (eye worm) hypothetical protein 0.0477 0.2165 0.4857
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0054 0.0131
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0101 0.0322 0.0784
Echinococcus multilocularis transient receptor potential cation channel 0.0101 0.0322 0.0784
Echinococcus multilocularis short transient receptor potential channel 6 0.0101 0.0322 0.0784
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0081 0.0225 0.0511
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0081 0.0225 0.0549
Leishmania major hypothetical protein, conserved 0.0101 0.0322 0.17
Loa Loa (eye worm) hypothetical protein 0.0101 0.0322 0.0631
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0081 0.0225 0.0549
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0047 0.0114
Echinococcus multilocularis potassium voltage gated channel protein 0.0101 0.0322 0.0784
Loa Loa (eye worm) transcription factor SMAD2 0.014 0.0514 0.1072
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0101 0.0322 0.073
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0101 0.0322 0.0784
Schistosoma mansoni ryanodine receptor related 0.0101 0.0322 0.0784
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0047 0.0114
Loa Loa (eye worm) hypothetical protein 0.0286 0.1226 0.2706
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0054 0.0131
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0101 0.0322 0.0784
Brugia malayi Abnormal catecholamine distribution protein 1 0.0184 0.0727 0.165
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0101 0.0322 0.073
Schistosoma mansoni voltage-gated potassium channel 0.0101 0.0322 0.0784
Toxoplasma gondii transporter, cation channel family protein 0.0101 0.0322 0.2283
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0101 0.0322 0.0784
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0101 0.0322 0.0784
Schistosoma mansoni voltage-gated potassium channel 0.0101 0.0322 0.0784
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0101 0.0322 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.04 0.065
Echinococcus multilocularis synaptic vesicular amine transporter 0.0184 0.0727 0.1772
Schistosoma mansoni transient receptor potential channel 0.0101 0.0322 0.0784
Echinococcus multilocularis protoporphyrinogen oxidase 0.0286 0.1226 0.299
Schistosoma mansoni voltage-gated potassium channel 0.0101 0.0322 0.0784
Mycobacterium tuberculosis Conserved hypothetical protein 0.0286 0.1226 0.1372
Plasmodium falciparum amino acid transporter, putative 0.0081 0.0225 0.1459
Onchocerca volvulus 0.0477 0.2165 0.4638
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0286 0.1226 1
Schistosoma mansoni voltage-gated potassium channel 0.0101 0.0322 0.0784
Echinococcus granulosus potassium voltage gated channel protein 0.0101 0.0322 0.0784
Schistosoma mansoni two-pore calcium channel 0.0101 0.0322 0.0784
Schistosoma mansoni voltage-gated potassium channel 0.0101 0.0322 0.0784
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0343 0.0338
Plasmodium vivax hypothetical protein, conserved 0.0286 0.1226 1
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0101 0.0322 0.0784
Brugia malayi SWIRM domain containing protein 0.0936 0.4408 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0322 0.0631
Schistosoma mansoni transient receptor potential channel 0.0101 0.0322 0.0784
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0101 0.0322 0.17
Schistosoma mansoni voltage-gated potassium channel 0.0101 0.0322 0.0784
Echinococcus multilocularis sodium leak channel non selective protein 0.0101 0.0322 0.0784
Echinococcus granulosus shaker cognate 0.0101 0.0322 0.0784
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0101 0.0322 0.0784
Loa Loa (eye worm) hypothetical protein 0.0101 0.0322 0.0631
Chlamydia trachomatis protoporphyrinogen oxidase 0.0286 0.1226 1
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0101 0.0322 0.073
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0101 0.0322 0.17
Loa Loa (eye worm) hypothetical protein 0.0188 0.0748 0.1609
Mycobacterium tuberculosis Probable reductase 0.0105 0.0343 0.0338
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0101 0.0322 0.0631
Loa Loa (eye worm) hypothetical protein 0.0101 0.0322 0.0631
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0101 0.0322 0.0784
Echinococcus granulosus transient receptor potential cation channel 0.0101 0.0322 0.0784
Leishmania major C-8 sterol isomerase-like protein 0.0368 0.1628 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0101 0.0322 0.0784
Schistosoma mansoni vesicular amine transporter 0.0184 0.0727 0.1772
Echinococcus multilocularis short transient receptor potential channel 6 0.0101 0.0322 0.0784
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0101 0.0322 0.2283
Echinococcus granulosus voltage dependent calcium channel 0.0101 0.0322 0.0784
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0101 0.0322 0.073
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0081 0.0225 0.1459
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0101 0.0322 0.0784
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0081 0.0225 0.0549
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0101 0.0322 0.073
Schistosoma mansoni voltage-gated potassium channel 0.0101 0.0322 0.0784
Echinococcus granulosus transient receptor potential cation channel 0.0101 0.0322 0.0784
Brugia malayi olfactory channel protein osm-9 0.0101 0.0322 0.073
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0081 0.0225 0.0549
Echinococcus multilocularis transient receptor potential cation channel 0.0101 0.0322 0.0784
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0101 0.0322 0.073
Echinococcus granulosus transient receptor potential cation channel 0.0101 0.0322 0.0784
Echinococcus granulosus transient receptor potential cation channel 0.0101 0.0322 0.0784
Loa Loa (eye worm) hypothetical protein 0.0193 0.0771 0.1661
Echinococcus multilocularis microtubule associated protein 2 0.081 0.3791 0.924
Echinococcus multilocularis potassium large conductance calcium activated 0.0101 0.0322 0.0784
Echinococcus granulosus potassium voltage gated channel protein 0.0101 0.0322 0.0784
Echinococcus multilocularis two pore calcium channel protein 2 0.0101 0.0322 0.0784
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0101 0.0322 0.0784
Schistosoma mansoni voltage-gated potassium channel 0.0101 0.0322 0.0784
Echinococcus granulosus potassium voltage gated channel protein 0.0101 0.0322 0.0784
Loa Loa (eye worm) serotonin transporter b 0.0477 0.2165 0.4857
Echinococcus granulosus two pore calcium channel protein 1 0.0101 0.0322 0.0784
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0101 0.0322 0.17
Plasmodium vivax hypothetical protein, conserved 0.0286 0.1226 1
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0101 0.0322 0.0784
Echinococcus granulosus microtubule associated protein 2 0.081 0.3791 0.924
Schistosoma mansoni transient receptor potential channel 4 0.0101 0.0322 0.0784
Schistosoma mansoni voltage-gated potassium channel 0.0101 0.0322 0.0784
Loa Loa (eye worm) glutathione reductase 0.0046 0.0054 0.0017
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0081 0.0225 0.0409
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0101 0.0322 0.0231
Schistosoma mansoni voltage-gated potassium channel 0.0101 0.0322 0.0784
Loa Loa (eye worm) hypothetical protein 0.0286 0.1226 0.2706
Schistosoma mansoni amine oxidase 0.0286 0.1226 0.299
Echinococcus multilocularis sodium and chloride dependent glycine 0.0081 0.0225 0.0549
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0873 0.4102 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0322 0.0631
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0101 0.0322 0.0784
Loa Loa (eye worm) hypothetical protein 0.0081 0.0225 0.0409
Loa Loa (eye worm) voltage-dependent calcium channel 0.0101 0.0322 0.0631
Echinococcus granulosus calcium activated potassium channel 0.0101 0.0322 0.0784
Loa Loa (eye worm) hypothetical protein 0.0348 0.1532 0.3406
Echinococcus multilocularis potassium voltage gated channel protein 0.0101 0.0322 0.0784
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0101 0.0322 0.0784
Loa Loa (eye worm) hypothetical protein 0.0101 0.0322 0.0631
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0101 0.0322 0.0784
Schistosoma mansoni voltage-gated potassium channel 0.0101 0.0322 0.0784
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0101 0.0322 0.0784
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0101 0.0322 0.0784
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0101 0.0322 0.0784
Brugia malayi Thioredoxin reductase 0.0046 0.0054 0.0122
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0101 0.0322 0.0784
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0047 0.0114
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0101 0.0322 0.073
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0054 0.0017
Entamoeba histolytica SWIRM domain protein 0.0062 0.0134 1
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0101 0.0322 0.17
Echinococcus multilocularis voltage gated potassium channel 0.0101 0.0322 0.0784
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0477 0.2165 0.5277
Toxoplasma gondii hypothetical protein 0.0081 0.0225 0.1459
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0081 0.0225 0.0511
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0101 0.0322 0.073
Toxoplasma gondii SWIRM domain-containing protein 0.0062 0.0134 0.0681
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0101 0.0322 0.0784
Echinococcus multilocularis transient receptor potential cation channel 0.0101 0.0322 0.0784
Brugia malayi Transient-receptor-potential like protein 0.0101 0.0322 0.073
Schistosoma mansoni voltage-gated potassium channel 0.0101 0.0322 0.0784
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0081 0.0225 0.1459
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0101 0.0322 0.0784
Loa Loa (eye worm) hypothetical protein 0.0081 0.0225 0.0409
Mycobacterium tuberculosis Possible oxidoreductase 0.0286 0.1226 0.1372
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0101 0.0322 0.0784
Schistosoma mansoni amine oxidase 0.0286 0.1226 0.299
Echinococcus granulosus sodium leak channel non selective protein 0.0101 0.0322 0.0784
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0101 0.0322 0.0631
Echinococcus multilocularis shaker cognate 0.0101 0.0322 0.0784
Echinococcus granulosus sodium and chloride dependent glycine 0.0081 0.0225 0.0549
Loa Loa (eye worm) hypothetical protein 0.0101 0.0322 0.0631
Loa Loa (eye worm) ryanodine receptor 0.0101 0.0322 0.0631
Plasmodium vivax hypothetical protein, conserved 0.0081 0.0225 0.1459
Schistosoma mansoni calcium-activated potassium channel 0.0101 0.0322 0.0784
Loa Loa (eye worm) hypothetical protein 0.0936 0.4408 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0081 0.0225 0.0549
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.2078 1 1
Echinococcus granulosus serotonin transporter 0.0477 0.2165 0.5277
Loa Loa (eye worm) hypothetical protein 0.0101 0.0322 0.0631
Brugia malayi MH2 domain containing protein 0.014 0.0514 0.1166
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0101 0.0322 0.0784
Loa Loa (eye worm) hypothetical protein 0.0101 0.0322 0.0631
Loa Loa (eye worm) hypothetical protein 0.0101 0.0322 0.0631
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0101 0.0322 0.073
Echinococcus granulosus voltage gated hydrogen channel 1 0.0101 0.0322 0.0784
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0101 0.0322 0.0784
Loa Loa (eye worm) hypothetical protein 0.0101 0.0322 0.0631
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0101 0.0322 0.0784
Echinococcus granulosus ryanodine receptor 44f 0.0101 0.0322 0.0784
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0062 0.0134 0.0326
Echinococcus granulosus transient receptor potential gamma protein 0.0101 0.0322 0.0784
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0081 0.0225 0.1459
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0081 0.0225 0.0549
Echinococcus multilocularis 0.0286 0.1226 0.299
Loa Loa (eye worm) hypothetical protein 0.0477 0.2165 0.4857
Brugia malayi voltage-dependent calcium channel 0.0101 0.0322 0.073
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0343 0.0338
Loa Loa (eye worm) hypothetical protein 0.0873 0.4102 0.93
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0081 0.0225 0.0549
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0101 0.0322 0.0784
Schistosoma mansoni SWI/SNF complex-related 0.0062 0.0134 0.0326
Echinococcus granulosus lysine specific histone demethylase 1A 0.0873 0.4102 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0081 0.0225 0.0549
Loa Loa (eye worm) hypothetical protein 0.0873 0.4102 0.93
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0081 0.0225 0.0549
Echinococcus multilocularis transient receptor potential cation channel 0.0101 0.0322 0.0784
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0081 0.0225 0.0409
Schistosoma mansoni transient receptor potential channel 0.0101 0.0322 0.0784

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) > 100 uM Cytotoxicity against HEL ChEMBL. 23743443

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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