Detailed information for compound 1762630

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 706.946 | Formula: C40H66O10
  • H donors: 6 H acceptors: 6 LogP: 5.44 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 3
  • SMILES: CC[C@@H](C(C)C)/C=C/[C@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CC=C2[C@]1(C)CC[C@@H](C2)O[C@@H]1OC[C@H]([C@@H]([C@H]1O[C@@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)O)O)O)O)C
  • InChi: 1S/C40H66O10/c1-7-23(21(2)3)9-8-22(4)27-12-13-28-26-11-10-24-18-25(14-16-39(24,5)29(26)15-17-40(27,28)6)48-38-36(32(43)30(42)20-47-38)50-37-35(46)34(45)33(44)31(19-41)49-37/h8-10,21-23,25-38,41-46H,7,11-20H2,1-6H3/b9-8+/t22-,23-,25+,26+,27-,28+,29+,30-,31-,32+,33-,34+,35-,36-,37+,38+,39+,40-/m1/s1
  • InChiKey: RYRHMRRZWNWNKA-YSJQLQQBSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tyrosine kinase 0.00609988 0.026197 0.0322198
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0140035 0.0832802 0.422749
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.00924328 0.0488999 0.0488999
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0140035 0.0832802 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0140035 0.0832802 0.422749
Schistosoma mansoni cell adhesion molecule 0.00315325 0.0049151 0.00604512
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.00562338 0.0227554 0.027987
Trichomonas vaginalis CK1 family protein kinase 0.00924328 0.0488999 0.195753
Brugia malayi casein kinase 1, delta 0.00924328 0.0488999 0.0488999
Echinococcus granulosus integrin alpha ps 0.0138349 0.082063 0.10093
Echinococcus multilocularis lachesin 0.00562338 0.0227554 0.027987
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.00315325 0.0049151 0.00604512
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0140035 0.0832802 0.102427
Loa Loa (eye worm) hypothetical protein 0.0285626 0.188432 0.188432
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.00766516 0.0375021 0.173462
Echinococcus granulosus Immunoglobulin subtype 0.00315325 0.0049151 0.00604512
Giardia lamblia hypothetical protein 0.0140035 0.0832802 0.0449904
Schistosoma mansoni septate junction protein 0.00562338 0.0227554 0.027987
Entamoeba histolytica serine/threonine protein kinase, putative 0.0261087 0.17071 1
Schistosoma mansoni kinase 0.0654665 0.454969 0.559569
Brugia malayi Immunoglobulin I-set domain containing protein 0.00562338 0.0227554 0.0227554
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0140035 0.0832802 0.0832802
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0140035 0.0832802 0.45751
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0140035 0.0832802 0.422749
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0140035 0.0832802 0.45751
Trichomonas vaginalis conserved hypothetical protein 0.0140035 0.0832802 0.422749
Loa Loa (eye worm) LAD-2 short isoform 0.00315325 0.0049151 0.0049151
Trichomonas vaginalis CAMK family protein kinase 0.0261087 0.17071 1
Onchocerca volvulus Dual oxidase homolog 0.0037945 0.00954648 0.0100654
Brugia malayi Immunoglobulin I-set domain containing protein 0.00562338 0.0227554 0.0227554
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0140035 0.0832802 0.422749
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0140035 0.0832802 0.45751
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0140035 0.0832802 0.45751
Brugia malayi basement membrane proteoglycan 0.00315325 0.0049151 0.0049151
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0140035 0.0832802 0.0590254
Echinococcus multilocularis insulin receptor 0.00609988 0.026197 0.0322198
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0140035 0.0832802 0.0590254
Loa Loa (eye worm) hypothetical protein 0.00645782 0.0287821 0.0287821
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.00609988 0.026197 0.0322198
Brugia malayi Protein kinase domain containing protein 0.00782604 0.0386641 0.0386641
Schistosoma mansoni hypothetical protein 0.0138349 0.082063 0.10093
Echinococcus multilocularis Immunoglobulin 0.00645522 0.0287634 0.0353763
Trypanosoma cruzi hypothetical protein, conserved 0.0140035 0.0832802 0.45751
Schistosoma mansoni serine/threonine protein kinase 0.00274972 0.00200059 0.00246054
Echinococcus granulosus roundabout 2 0.00562338 0.0227554 0.027987
Loa Loa (eye worm) blistered cuticle protein 3 0.0037945 0.00954648 0.00954648
Echinococcus granulosus insulin receptor 0.00609988 0.026197 0.0322198
Brugia malayi Immunoglobulin I-set domain containing protein 0.00399387 0.0109865 0.0109865
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0140035 0.0832802 0.45751
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0140035 0.0832802 0.102427
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0140035 0.0832802 0.45751
Schistosoma mansoni hypothetical protein 0.00315325 0.0049151 0.00604512
Schistosoma mansoni nephrin 0.00562338 0.0227554 0.027987
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.00315325 0.0049151 0.00604512
Schistosoma mansoni titin 0.00274972 0.00200059 0.00246054
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0252043 0.164178 0.164178
Loa Loa (eye worm) hypothetical protein 0.00645522 0.0287634 0.0287634
Echinococcus multilocularis titin 0.00274972 0.00200059 0.00246054
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0140035 0.0832802 0.422749
Loa Loa (eye worm) hypothetical protein 0.00645522 0.0287634 0.0287634
Schistosoma mansoni hypothetical protein 0.00315325 0.0049151 0.00604512
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0140035 0.0832802 0.0590254
Loa Loa (eye worm) hypothetical protein 0.115048 0.81307 0.81307
Loa Loa (eye worm) hypothetical protein 0.00562338 0.0227554 0.0227554
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.00645522 0.0287634 0.0353763
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.044496 0.303511 0.37329
Loa Loa (eye worm) hypothetical protein 0.0150276 0.090677 0.090677
Echinococcus granulosus casein kinase I delta 0.00924328 0.0488999 0.0601423
Echinococcus granulosus integrin alpha 3 0.0273699 0.179818 0.22116
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.101045 0.711931 0.711931
Schistosoma mansoni neuroglian 0.00562338 0.0227554 0.027987
Brugia malayi Kelch motif family protein 0.00326706 0.00573704 0.00573704
Loa Loa (eye worm) hypothetical protein 0.00562338 0.0227554 0.0227554
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.00315325 0.0049151 0.00604512
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.00562338 0.0227554 0.027987
Brugia malayi Prion-like- 0.00562338 0.0227554 0.0227554
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0140035 0.0832802 0.45751
Brugia malayi Immunoglobulin domain containing protein 0.00315325 0.0049151 0.0049151
Loa Loa (eye worm) hypothetical protein 0.00562338 0.0227554 0.0227554
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.00274972 0.00200059 0.00200059
Loa Loa (eye worm) CAMK protein kinase 0.00274972 0.00200059 0.00200059
Echinococcus granulosus lachesin 0.00562338 0.0227554 0.027987
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0140035 0.0832802 0.422749
Loa Loa (eye worm) hypothetical protein 0.00562338 0.0227554 0.0227554
Schistosoma mansoni tyrosine kinase 0.00775072 0.03812 0.0468841
Echinococcus granulosus integrin beta 2 0.0161829 0.099021 0.121787
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0140035 0.0832802 0.422749
Brugia malayi serine/threonine-protein kinase plk-2 0.0261087 0.17071 0.17071
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0140035 0.0832802 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0140035 0.0832802 0.422749
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0140035 0.0832802 0.102427
Onchocerca volvulus Serine\/threonine kinase homolog 0.0261087 0.17071 0.179989
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0140035 0.0832802 0.422749
Loa Loa (eye worm) dihydrofolate reductase 0.0200473 0.126932 0.126932
Echinococcus granulosus contactin 0.00562338 0.0227554 0.027987
Brugia malayi casein kinase I 0.00924328 0.0488999 0.0488999
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0140035 0.0832802 0.45751
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0140035 0.0832802 0.422749
Echinococcus granulosus pro neuregulin 2 membrane bound 0.00315325 0.0049151 0.00604512
Leishmania major hypothetical protein, conserved 0.0140035 0.0832802 0.45751
Schistosoma mansoni roundabout 0.00562338 0.0227554 0.027987
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.115048 0.81307 1
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.00315325 0.0049151 0.00604512
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.00315325 0.0049151 0.00604512
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0140035 0.0832802 0.422749
Brugia malayi Furin-like cysteine rich region family protein 0.0160205 0.0978478 0.0978478
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0200473 0.126932 0.5
Brugia malayi protein unc-22 0.00274972 0.00200059 0.00200059
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.115048 0.81307 1
Schistosoma mansoni septate junction protein 0.00315325 0.0049151 0.00604512
Loa Loa (eye worm) PDE1B protein 0.0140035 0.0832802 0.0832802
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0140035 0.0832802 1
Schistosoma mansoni integrin alpha-ps 0.0150276 0.090677 0.111524
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0140035 0.0832802 0.102427
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0140035 0.0832802 0.0832802
Brugia malayi hypothetical protein 0.00315325 0.0049151 0.0049151
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.00562338 0.0227554 0.027987
Trichomonas vaginalis conserved hypothetical protein 0.0140035 0.0832802 0.422749
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.115048 0.81307 1
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0140035 0.0832802 0.45751
Schistosoma mansoni cell adhesion molecule 0.00315325 0.0049151 0.00604512
Echinococcus multilocularis casein kinase I delta 0.00924328 0.0488999 0.0601423
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0140035 0.0832802 0.422749
Echinococcus multilocularis Immunoglobulin 0.00315325 0.0049151 0.00604512
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0140035 0.0832802 0.422749
Loa Loa (eye worm) hypothetical protein 0.00315325 0.0049151 0.0049151
Echinococcus multilocularis integrin alpha ps 0.0288626 0.190599 0.234419
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.00562338 0.0227554 0.027987
Schistosoma mansoni tyrosine kinase 0.00927447 0.0491252 0.0604195
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.00590297 0.0247748 0.0247748
Echinococcus granulosus epidermal growth factor receptor 0.0160205 0.0978478 0.120344
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0140035 0.0832802 0.422749
Loa Loa (eye worm) hypothetical protein 0.00645522 0.0287634 0.0287634
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0261087 0.17071 0.17071
Echinococcus granulosus neuroglian 0.00892534 0.0466037 0.0573182
Trypanosoma cruzi casein kinase, putative 0.00924328 0.0488999 0.244184
Trypanosoma cruzi casein kinase, putative 0.00924328 0.0488999 0.244184
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0140035 0.0832802 0.102427
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0140035 0.0832802 0.422749
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0140035 0.0832802 0.422749
Schistosoma mansoni dihydrofolate reductase 0.0200473 0.126932 0.156114
Onchocerca volvulus 0.00924328 0.0488999 0.0515581
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.00766516 0.0375021 0.173462
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0140035 0.0832802 1
Echinococcus multilocularis Immunoglobulin subtype 0.00315325 0.0049151 0.00604512
Echinococcus multilocularis casein kinase I alpha 0.00924328 0.0488999 0.0601423
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0140035 0.0832802 0.0590254
Schistosoma mansoni hypothetical protein 0.00315325 0.0049151 0.00604512
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0140035 0.0832802 0.422749
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0140035 0.0832802 0.102427
Schistosoma mansoni vesicular amine transporter 0.00645522 0.0287634 0.0353763
Loa Loa (eye worm) hypothetical protein 0.00315325 0.0049151 0.0049151
Echinococcus granulosus casein kinase I alpha 0.00924328 0.0488999 0.0601423
Echinococcus multilocularis basement membrane specific heparan sulfate 0.00315325 0.0049151 0.00604512
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0140035 0.0832802 0.102427
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.115048 0.81307 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.00315325 0.0049151 0.0049151
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.044496 0.303511 0.37329
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0140035 0.0832802 1
Leishmania major casein kinase, putative 0.00924328 0.0488999 0.244184
Schistosoma mansoni peroxidasin 0.00315585 0.00493386 0.00606819
Giardia lamblia Hypothetical protein 0.0140035 0.0832802 0.0449904
Echinococcus multilocularis basement membrane specific heparan sulfate 0.00645522 0.0287634 0.0353763
Echinococcus multilocularis neuroglian 0.00562338 0.0227554 0.027987
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0140035 0.0832802 0.422749
Echinococcus multilocularis integrin alpha ps 0.0288626 0.190599 0.234419
Echinococcus granulosus integrin alpha ps 0.0288626 0.190599 0.234419
Echinococcus granulosus Immunoglobulin 0.00645522 0.0287634 0.0353763
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0140035 0.0832802 0.422749
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.101045 0.711931 0.875608
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0140035 0.0832802 0.422749
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0140035 0.0832802 0.102427
Schistosoma mansoni serine/threonine protein kinase 0.0261087 0.17071 0.209957
Loa Loa (eye worm) hypothetical protein 0.00562338 0.0227554 0.0227554
Brugia malayi Immunoglobulin I-set domain containing protein 0.00562338 0.0227554 0.0227554
Trichomonas vaginalis conserved hypothetical protein 0.0140035 0.0832802 0.422749
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0140035 0.0832802 0.422749
Schistosoma mansoni cell adhesion molecule 0.00960847 0.0515376 0.0633864
Schistosoma mansoni netrin receptor unc5 0.00315325 0.0049151 0.00604512
Echinococcus granulosus peroxidasin 0.00562597 0.0227742 0.0280101
Schistosoma mansoni basigin related 0.00315325 0.0049151 0.00604512
Schistosoma mansoni hypothetical protein 0.00315325 0.0049151 0.00604512
Trypanosoma cruzi casein kinase, putative 0.00924328 0.0488999 0.244184
Trypanosoma cruzi casein kinase, delta isoform, putative 0.00924328 0.0488999 0.244184
Loa Loa (eye worm) hypothetical protein 0.00562597 0.0227742 0.0227742
Brugia malayi Immunoglobulin I-set domain containing protein 0.00274972 0.00200059 0.00200059
Brugia malayi Immunoglobulin I-set domain containing protein 0.00315325 0.0049151 0.0049151
Loa Loa (eye worm) hypothetical protein 0.00315325 0.0049151 0.0049151
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.00399387 0.0109865 0.0135123
Onchocerca volvulus 0.00274972 0.00200059 0.00210934
Schistosoma mansoni cell adhesion molecule 0.00562338 0.0227554 0.027987
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0140035 0.0832802 0.0590254
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.00960847 0.0515376 0.0633864
Schistosoma mansoni netrin receptor unc5 0.00315325 0.0049151 0.00604512
Trichomonas vaginalis CAMK family protein kinase 0.0261087 0.17071 1
Trypanosoma cruzi hypothetical protein, conserved 0.0140035 0.0832802 0.45751
Loa Loa (eye worm) TK/KIN16 protein kinase 0.14093 1 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0140035 0.0832802 0.0590254
Trichomonas vaginalis CAMK family protein kinase 0.0261087 0.17071 1
Brugia malayi hypothetical protein 0.00326706 0.00573704 0.00573704
Schistosoma mansoni tyrosine kinase 0.00714713 0.0337606 0.0415224
Echinococcus granulosus titin 0.00274972 0.00200059 0.00246054
Schistosoma mansoni nephrin related 0.00315325 0.0049151 0.00604512
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0140035 0.0832802 0.422749
Echinococcus multilocularis epidermal growth factor receptor 0.00927447 0.0491252 0.0604195
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.00782604 0.0386641 0.0475532
Brugia malayi Immunoglobulin I-set domain containing protein 0.00562338 0.0227554 0.0227554
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0140035 0.0832802 0.0832802
Onchocerca volvulus Tyrosine kinase homolog 0.133792 0.948444 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0140035 0.0832802 0.45751
Loa Loa (eye worm) integrin beta-2 0.0217561 0.139273 0.139273
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.115048 0.81307 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.00562338 0.0227554 0.0227554
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0140035 0.0832802 0.102427
Leishmania major cAMP-specific phosphodiesterase, putative 0.0140035 0.0832802 0.45751
Trypanosoma brucei polo-like protein kinase 0.0261087 0.17071 1
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.00924328 0.0488999 0.0488999
Loa Loa (eye worm) hypothetical protein 0.00562338 0.0227554 0.0227554
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0140035 0.0832802 0.0590254
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0140035 0.0832802 0.102427
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0140035 0.0832802 0.422749
Brugia malayi basement membrane proteoglycan precursor 0.00315325 0.0049151 0.0049151
Echinococcus granulosus titin 0.00274972 0.00200059 0.00246054
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.00562338 0.0227554 0.027987
Brugia malayi dihydrofolate reductase family protein 0.0200473 0.126932 0.126932
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0140035 0.0832802 0.45751
Loa Loa (eye worm) integrin alpha pat-2 0.0537669 0.370469 0.370469
Schistosoma mansoni integrin alpha-ps 0.0288626 0.190599 0.234419
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0140035 0.0832802 0.102427
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.00315325 0.0049151 0.00604512
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0140035 0.0832802 0.102427
Echinococcus multilocularis integrin beta 2 0.0161829 0.099021 0.121787
Loa Loa (eye worm) kelch domain-containing protein family protein 0.00326706 0.00573704 0.00573704
Loa Loa (eye worm) hypothetical protein 0.013535 0.0798963 0.0798963
Trichomonas vaginalis CAMK family protein kinase 0.0261087 0.17071 1
Trichomonas vaginalis CK1 family protein kinase 0.00924328 0.0488999 0.195753
Echinococcus granulosus neuroglian 0.00562338 0.0227554 0.027987
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0140035 0.0832802 0.0832802
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0140035 0.0832802 0.0590254
Brugia malayi Immunoglobulin domain containing protein 0.00315325 0.0049151 0.0049151
Brugia malayi Immunoglobulin I-set domain containing protein 0.00562338 0.0227554 0.0227554
Trypanosoma cruzi casein kinase, putative 0.00924328 0.0488999 0.244184
Brugia malayi Immunoglobulin I-set domain containing protein 0.00315325 0.0049151 0.0049151
Echinococcus granulosus casein kinase I alpha 0.00924328 0.0488999 0.0601423
Echinococcus multilocularis epidermal growth factor receptor 0.0160205 0.0978478 0.120344
Echinococcus multilocularis casein kinase I alpha 0.00924328 0.0488999 0.0601423
Brugia malayi Heparan sulfate 0.00315325 0.0049151 0.0049151
Echinococcus granulosus Down syndrome cell adhesion molecule 0.00315325 0.0049151 0.00604512
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0140035 0.0832802 0.102427
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.101045 0.711931 0.875608
Echinococcus multilocularis 0.00451264 0.0147332 0.0181204
Schistosoma mansoni hypothetical protein 0.00315325 0.0049151 0.00604512
Schistosoma mansoni tyrosine kinase 0.00609988 0.026197 0.0322198
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0140035 0.0832802 0.422749
Trichomonas vaginalis CAMK family protein kinase 0.0261087 0.17071 1
Loa Loa (eye worm) hypothetical protein 0.0120786 0.0693779 0.0693779
Schistosoma mansoni basigin related 0.00315325 0.0049151 0.00604512
Echinococcus multilocularis hemicentin 1 0.00562338 0.0227554 0.027987
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0140035 0.0832802 0.0590254
Schistosoma mansoni septate junction protein 0.00562338 0.0227554 0.027987
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0140035 0.0832802 0.102427
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0140035 0.0832802 0.102427
Brugia malayi Immunoglobulin I-set domain containing protein 0.00315585 0.00493386 0.00493386
Schistosoma mansoni tyrosine kinase 0.00927447 0.0491252 0.0604195
Trypanosoma cruzi hypothetical protein, conserved 0.0140035 0.0832802 0.45751
Brugia malayi Integrin beta pat-3 precursor 0.0217561 0.139273 0.139273
Trichomonas vaginalis CAMK family protein kinase 0.0261087 0.17071 1
Leishmania major hypothetical protein, conserved 0.0140035 0.0832802 0.45751
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0140035 0.0832802 0.422749
Loa Loa (eye worm) hypothetical protein 0.0140035 0.0832802 0.0832802
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0140035 0.0832802 0.0590254
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0140035 0.0832802 0.422749
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0140035 0.0832802 1
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.00785228 0.0388535 0.0477862
Trypanosoma cruzi hypothetical protein, conserved 0.0140035 0.0832802 0.45751
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0140035 0.0832802 0.422749
Schistosoma mansoni cell adhesion molecule 0.00562338 0.0227554 0.027987
Echinococcus granulosus casein kinase I delta 0.00924328 0.0488999 0.0601423
Echinococcus granulosus low density lipoprotein receptor ldl 0.00315325 0.0049151 0.00604512
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0140035 0.0832802 0.0590254
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0140035 0.0832802 0.0832802
Schistosoma mansoni Neurotrimin precursor (hNT) 0.00645522 0.0287634 0.0353763
Echinococcus granulosus Immunoglobulin 0.00315325 0.0049151 0.00604512
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0140035 0.0832802 0.45751
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0140035 0.0832802 0.0590254
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0261087 0.17071 1
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.00315325 0.0049151 0.00604512
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0140035 0.0832802 0.0590254
Echinococcus granulosus 3'partial|cell adhesion molecule:down regulated by 0.00315325 0.0049151 0.00604512
Plasmodium vivax casein kinase 1, putative 0.00924328 0.0488999 0.24898
Loa Loa (eye worm) TK/ROR protein kinase 0.00399387 0.0109865 0.0109865
Echinococcus multilocularis Immunoglobulin 0.00315325 0.0049151 0.00604512
Schistosoma mansoni tyrosine kinase 0.0160205 0.0978478 0.120344
Loa Loa (eye worm) hypothetical protein 0.0120786 0.0693779 0.0693779
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0140035 0.0832802 0.102427
Echinococcus multilocularis tyrosine protein kinase otk 0.00562338 0.0227554 0.027987
Loa Loa (eye worm) TK/EGFR protein kinase 0.0160205 0.0978478 0.0978478
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.115048 0.81307 1
Echinococcus multilocularis peroxidasin 0.00562597 0.0227742 0.0280101
Brugia malayi hypothetical protein 0.00645522 0.0287634 0.0287634
Echinococcus granulosus roundabout 2 0.0120786 0.0693779 0.0853283
Leishmania major dihydrofolate reductase-thymidylate synthase 0.00766516 0.0375021 0.173462
Schistosoma mansoni tyrosine kinase 0.00775072 0.03812 0.0468841
Schistosoma mansoni protein kinase 0.00924328 0.0488999 0.0601423
Echinococcus multilocularis roundabout 2 0.0120786 0.0693779 0.0853283
Brugia malayi Immunoglobulin I-set domain containing protein 0.00562338 0.0227554 0.0227554
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.00562338 0.0227554 0.027987
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.101045 0.711931 0.711931
Trypanosoma cruzi casein kinase, putative 0.00924328 0.0488999 0.244184
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0140035 0.0832802 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0140035 0.0832802 0.422749
Schistosoma mansoni septate junction protein 0.00315325 0.0049151 0.00604512
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0140035 0.0832802 0.0590254
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0140035 0.0832802 0.422749
Schistosoma mansoni hypothetical protein 0.00315325 0.0049151 0.00604512
Chlamydia trachomatis dihydrofolate reductase 0.0200473 0.126932 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0261087 0.17071 1
Echinococcus granulosus twitchin 0.00920494 0.048623 0.0598018
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0140035 0.0832802 0.422749
Echinococcus multilocularis integrin alpha 3 0.0273699 0.179818 0.22116
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.00562338 0.0227554 0.027987
Onchocerca volvulus Basement membrane proteoglycan homolog 0.00562338 0.0227554 0.0239924
Onchocerca volvulus 0.00896368 0.0468806 0.049429
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0140035 0.0832802 0.422749
Echinococcus multilocularis netrin receptor unc 5 0.00315325 0.0049151 0.00604512
Loa Loa (eye worm) hypothetical protein 0.00326706 0.00573704 0.00573704
Echinococcus multilocularis neuroglian 0.00892534 0.0466037 0.0573182
Trichomonas vaginalis CK1 family protein kinase 0.00924328 0.0488999 0.195753
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0140035 0.0832802 0.422749
Schistosoma mansoni integrin alpha 0.0423975 0.288354 0.354649
Schistosoma mansoni cell adhesion molecule 0.00562338 0.0227554 0.027987
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.115048 0.81307 1
Echinococcus multilocularis roundabout 2 0.00562338 0.0227554 0.027987
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0261087 0.17071 0.209957
Toxoplasma gondii casein kinase I 0.00924328 0.0488999 0.0146961
Echinococcus multilocularis integrin alpha ps 0.0138349 0.082063 0.10093
Echinococcus multilocularis Immunoglobulin 0.00645522 0.0287634 0.0353763
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0140035 0.0832802 0.0590254
Echinococcus multilocularis leucine rich repeat containing protein 4 0.00315325 0.0049151 0.00604512
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0261087 0.17071 0.209957
Echinococcus granulosus insulin growth factor 1 receptor beta 0.00609988 0.026197 0.0322198
Loa Loa (eye worm) hypothetical protein 0.00315325 0.0049151 0.0049151
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0140035 0.0832802 0.0590254
Trypanosoma cruzi hypothetical protein, conserved 0.0140035 0.0832802 0.45751
Trypanosoma cruzi hypothetical protein, conserved 0.0140035 0.0832802 0.45751
Echinococcus multilocularis roundabout 2 0.00562338 0.0227554 0.027987
Loa Loa (eye worm) hypothetical protein 0.0138349 0.082063 0.082063
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.00562338 0.0227554 0.0227554
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0140035 0.0832802 0.102427
Loa Loa (eye worm) hypothetical protein 0.00562338 0.0227554 0.0227554
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0140035 0.0832802 0.102427
Schistosoma mansoni titin 0.00562338 0.0227554 0.027987
Echinococcus granulosus basement membrane specific heparan sulfate 0.00315325 0.0049151 0.00604512
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0140035 0.0832802 0.422749
Echinococcus granulosus netrin receptor unc 5 0.00315325 0.0049151 0.00604512
Echinococcus granulosus casein kinase i 0.00924328 0.0488999 0.0601423
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0140035 0.0832802 0.422749
Loa Loa (eye worm) hypothetical protein 0.00645522 0.0287634 0.0287634
Trypanosoma cruzi casein kinase, delta isoform, putative 0.00896368 0.0468806 0.231654
Brugia malayi Fibronectin type III domain containing protein 0.00645522 0.0287634 0.0287634
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.00924328 0.0488999 0.0488999
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.00315325 0.0049151 0.00604512
Echinococcus multilocularis twitchin 0.00274972 0.00200059 0.00246054
Brugia malayi Immunoglobulin I-set domain containing protein 0.00562338 0.0227554 0.0227554
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0140035 0.0832802 0.45751
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.00562338 0.0227554 0.0227554
Echinococcus granulosus roundabout 2 0.00562338 0.0227554 0.027987
Plasmodium falciparum phosphodiesterase delta, putative 0.0140035 0.0832802 1
Toxoplasma gondii cytochrome p450 superfamily protein 0.0814725 0.570571 0.687328
Echinococcus granulosus casein kinase I alpha 0.00924328 0.0488999 0.0601423
Echinococcus multilocularis casein kinase i 0.00924328 0.0488999 0.0601423
Echinococcus granulosus hemicentin 1 0.00562338 0.0227554 0.027987
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.00315325 0.0049151 0.0049151
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0140035 0.0832802 0.102427
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0140035 0.0832802 0.0832802
Loa Loa (eye worm) hypothetical protein 0.00315325 0.0049151 0.0049151
Schistosoma mansoni tyrosine kinase 0.00775072 0.03812 0.0468841
Echinococcus granulosus defective proboscis extension response 0.00645522 0.0287634 0.0353763
Loa Loa (eye worm) immunoglobulin domain-containing protein 0.00315325 0.0049151 0.0049151
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0140035 0.0832802 0.422749
Brugia malayi Protein kinase domain containing protein 0.00609988 0.026197 0.026197
Plasmodium vivax phosphodiesterase gamma, putative 0.0140035 0.0832802 1
Echinococcus granulosus epidermal growth factor receptor 0.00927447 0.0491252 0.0604195
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0140035 0.0832802 0.422749
Echinococcus granulosus tyrosine protein kinase otk 0.00562338 0.0227554 0.027987
Schistosoma mansoni serine/threonine protein kinase 0.00924328 0.0488999 0.0601423
Echinococcus multilocularis dihydrofolate reductase 0.0200473 0.126932 0.156114
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0140035 0.0832802 0.422749
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0140035 0.0832802 0.422749
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0140035 0.0832802 0.102427
Echinococcus granulosus Immunoglobulin 0.00315325 0.0049151 0.00604512
Brugia malayi Peroxidasin 0.00562597 0.0227742 0.0227742
Loa Loa (eye worm) hypothetical protein 0.0140035 0.0832802 0.0832802
Loa Loa (eye worm) hypothetical protein 0.00960847 0.0515376 0.0515376
Brugia malayi Immunoglobulin domain containing protein 0.00315325 0.0049151 0.0049151
Loa Loa (eye worm) TKL/LRRK protein kinase 0.00782604 0.0386641 0.0386641
Brugia malayi Integrin alpha pat-2 precursor 0.0423975 0.288354 0.288354
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0140035 0.0832802 0.102427
Trypanosoma brucei hypothetical protein, conserved 0.0140035 0.0832802 0.45751
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0140035 0.0832802 0.422749
Echinococcus multilocularis cell adhesion molecule:down regulated by 0.00315325 0.0049151 0.00604512
Loa Loa (eye worm) hypothetical protein 0.00645522 0.0287634 0.0287634
Brugia malayi Immunoglobulin I-set domain containing protein 0.14093 1 1
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0200473 0.126932 0.5
Loa Loa (eye worm) TK/INSR protein kinase 0.00609988 0.026197 0.026197
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0140035 0.0832802 0.0832802
Onchocerca volvulus 0.129798 0.919598 0.969586
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0140035 0.0832802 0.422749
Trypanosoma cruzi polo-like protein kinase, putative 0.0261087 0.17071 1
Loa Loa (eye worm) hypothetical protein 0.0252043 0.164178 0.164178
Plasmodium falciparum phosphodiesterase gamma, putative 0.0140035 0.0832802 1
Schistosoma mansoni serine/threonine protein kinase 0.00274972 0.00200059 0.00246054
Schistosoma mansoni basigin related 0.00315325 0.0049151 0.00604512
Brugia malayi Dihydrofolate reductase 0.0200473 0.126932 0.126932
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.00927447 0.0491252 0.0604195
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.00562338 0.0227554 0.0227554
Schistosoma mansoni integrin beta subunit 0.0129158 0.0754249 0.0927655
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0140035 0.0832802 0.45751
Brugia malayi Immunoglobulin I-set domain containing protein 0.00562338 0.0227554 0.0227554
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0140035 0.0832802 0.0590254
Giardia lamblia Kinase, PLK 0.0261087 0.17071 0.159401
Brugia malayi Blistered cuticle protein 3 0.0037945 0.00954648 0.00954648
Brugia malayi Immunoglobulin I-set domain containing protein 0.00861695 0.0443763 0.0443763
Loa Loa (eye worm) hypothetical protein 0.0140035 0.0832802 0.0832802
Trypanosoma cruzi polo-like protein kinase, putative 0.0261087 0.17071 1
Echinococcus multilocularis contactin neuroglian septate junction protein 0.00562338 0.0227554 0.027987
Echinococcus multilocularis hemicentin 1 0.00562338 0.0227554 0.027987
Trypanosoma brucei casein kinase I, isoform 2 0.00924328 0.0488999 0.244184
Onchocerca volvulus Peroxidasin homolog 0.00250156 0.000208261 0.000219582
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0140035 0.0832802 0.422749
Plasmodium falciparum casein kinase 1 0.00924328 0.0488999 0.24898
Loa Loa (eye worm) TK protein kinase 0.00399387 0.0109865 0.0109865
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0200473 0.126932 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.00315325 0.0049151 0.0049151
Echinococcus multilocularis casein kinase I alpha 0.00924328 0.0488999 0.0601423
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0140035 0.0832802 0.45751
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.00399387 0.0109865 0.0135123
Schistosoma mansoni nephrin 0.00892534 0.0466037 0.0573182
Echinococcus granulosus dihydrofolate reductase 0.0200473 0.126932 0.156114
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0140035 0.0832802 0.102427
Echinococcus multilocularis casein kinase I delta 0.00924328 0.0488999 0.0601423
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0140035 0.0832802 0.422749
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0140035 0.0832802 0.422749

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 2.74 uM Antiplasmodial activity against Plasmodium falciparum W2 ChEMBL. 23562058

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 23562058

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.