Detailed information for compound 177023

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 355.432 | Formula: C23H21N3O
  • H donors: 2 H acceptors: 2 LogP: 5.24 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCNC(=O)c1ccc(cc1)Nc1c2ccccc2nc2c1cccc2
  • InChi: 1S/C23H21N3O/c1-2-15-24-23(27)16-11-13-17(14-12-16)25-22-18-7-3-5-9-20(18)26-21-10-6-4-8-19(21)22/h3-14H,2,15H2,1H3,(H,24,27)(H,25,26)
  • InChiKey: OHWUOJBVACHSGL-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.2774 0.5381 0.5372
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0331 0.0608 0.0608
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1723 0.3327 0.3312
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0023 0.0004
Toxoplasma gondii FATC domain-containing protein 0.0972 0.1859 0.2503
Echinococcus granulosus cyclic nucleotide gated cation channel 0.003 0.0019 0.0019
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0331 0.0608 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0331 0.0608 0.0608
Trichomonas vaginalis PIKK family atypical protein kinase 0.5137 1 1
Loa Loa (eye worm) hypothetical protein 0.0331 0.0608 0.0608
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0331 0.0608 0.0608
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0331 0.0608 0.0608
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0331 0.0608 0.0608
Schistosoma mansoni fkbp-rapamycin associated protein 0.0972 0.1859 0.1859
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0049 0.0055 0.0055
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0044 0.0047 0.0047
Giardia lamblia Hypothetical protein 0.0331 0.0608 0.0541
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0331 0.0608 0.059
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.243 0.4708 0.4696
Trichomonas vaginalis PIKK family atypical protein kinase 0.4086 0.7946 0.7942
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.003 0.0019 0.0019
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.5137 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0044 0.0047 0.0047
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.5137 1 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.003 0.0019 0.0019
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0331 0.0608 0.059
Trichomonas vaginalis PIKK family atypical protein kinase 0.1723 0.3327 0.3314
Schistosoma mansoni immunophilin 0.0056 0.007 0.007
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1723 0.3327 0.3327
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.003 0.0019 0.0019
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0153 0.0259 0.0259
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0331 0.0608 0.0608
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0331 0.0608 0.0818
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0056 0.007 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.3335 0.6478 0.6471
Schistosoma mansoni serine/threonine-protein kinase 0.0022 0.0003 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0331 0.0608 0.059
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0331 0.0608 0.0608
Trichomonas vaginalis PIKK family atypical protein kinase 0.1723 0.3327 0.3314
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0331 0.0608 0.0608
Loa Loa (eye worm) hypothetical protein 0.0044 0.0047 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.1723 0.3327 0.3314
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0056 0.007 0.1156
Echinococcus multilocularis Zinc finger, PHD finger 0.0331 0.0608 0.0608
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1723 0.3327 0.3327
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0331 0.0608 0.0608
Trichomonas vaginalis PIKK family atypical protein kinase 0.4086 0.7946 0.7942
Loa Loa (eye worm) phosphatidylinositol 3 0.0331 0.0608 0.0608
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0331 0.0608 0.059
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.5137 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0153 0.0259 0.0259
Trichomonas vaginalis PIKK family atypical protein kinase 0.307 0.5959 0.5951
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1723 0.3327 0.3327
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0023 0.0004
Trichomonas vaginalis fk506-binding protein, putative 0.0056 0.007 0.0051
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.5137 1 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0331 0.0608 0.0608
Entamoeba histolytica hypothetical protein 0.0331 0.0608 0.0605
Schistosoma mansoni serine/threonine-protein kinase 0.0022 0.0003 0.0003
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.4091 0.7954 0.7954
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0331 0.0608 0.059
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0023 0.0004
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.003 0.0019 0.0019
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0153 0.0259 0.0259
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0331 0.0608 0.0605
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0331 0.0608 0.0608
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0056 0.007 0.0067
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0331 0.0608 0.0541
Loa Loa (eye worm) AGC/AKT protein kinase 0.0032 0.0023 0.0023
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0331 0.0608 0.0608
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0972 0.1859 0.1856
Trichomonas vaginalis PIKK family atypical protein kinase 0.4086 0.7946 0.7942
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0331 0.0608 0.0586
Echinococcus multilocularis serine protein kinase ATM 0.0972 0.1859 0.1859
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0331 0.0608 0.0586
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0331 0.0608 0.0608
Toxoplasma gondii target of rapamycin (TOR), putative 0.3821 0.7427 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.3446 0.6695 0.6688
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0143 0.024 0.0221
Schistosoma mansoni hypothetical protein 0.0751 0.1428 0.1428
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0331 0.0608 0.0608
Trichomonas vaginalis PIKK family atypical protein kinase 0.5137 1 1
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0056 0.007 0.0047
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0331 0.0608 0.0608
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0331 0.0608 0.0605
Leishmania major hypothetical protein, conserved 0.0331 0.0608 0.0608
Entamoeba histolytica hypothetical protein 0.0972 0.1859 0.1856
Trichomonas vaginalis conserved hypothetical protein 0.1083 0.2076 0.2061
Brugia malayi Cyclic-nucleotide gated cation channel 0.003 0.0019 0.0019
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0331 0.0608 0.0605
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0751 0.1428 0.1428
Loa Loa (eye worm) phosphatidylinositol 3 0.5137 1 1
Loa Loa (eye worm) hypothetical protein 0.1083 0.2076 0.2076
Leishmania major peptidylprolyl isomerase-like protein 0.0056 0.007 0.007
Onchocerca volvulus 0.0331 0.0608 0.5
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0331 0.0608 0.0608
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0056 0.007 0.0067
Entamoeba histolytica protein kinase, putative 0.0032 0.0023 0.002
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0331 0.0608 0.0605
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0331 0.0608 0.0608
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0047 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.3821 0.7427 0.7422
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0331 0.0608 1
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0331 0.0608 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0331 0.0608 0.059
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0331 0.0608 0.0605
Echinococcus granulosus hyperpolarization activated cyclic 0.003 0.0019 0.0019
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0331 0.0608 0.0586
Trichomonas vaginalis PIKK family atypical protein kinase 0.3821 0.7427 0.7422
Trichomonas vaginalis PIKK family atypical protein kinase 0.3821 0.7427 0.7422
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0023 0.0004
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0331 0.0608 0.0608
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.003 0.0019 0.0019
Echinococcus granulosus cyclic nucleotide gated cation channel 0.003 0.0019 0.0019
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0056 0.007 0.5
Schistosoma mansoni immunophilin 0.0049 0.0055 0.0055
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0331 0.0608 0.0608
Echinococcus multilocularis voltage gated potassium channel 0.0044 0.0047 0.0047
Plasmodium vivax hypothetical protein, conserved 0.0331 0.0608 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0972 0.1859 0.1856
Trichomonas vaginalis conserved hypothetical protein 0.0751 0.1428 0.1412
Leishmania major fk506-binding protein 1-like protein 0.0056 0.007 0.007
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0331 0.0608 0.0541
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0331 0.0608 0.0605
Loa Loa (eye worm) hypothetical protein 0.0133 0.022 0.022
Trichomonas vaginalis PIKK family atypical protein kinase 0.2774 0.5381 0.5372
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0331 0.0608 0.0605
Trichomonas vaginalis PIKK family atypical protein kinase 0.4086 0.7946 0.7942
Leishmania major phosphatidylinositol 4-kinase, putative 0.0331 0.0608 0.0608
Trichomonas vaginalis PIKK family atypical protein kinase 0.277 0.5373 0.5364
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0972 0.1859 0.184
Loa Loa (eye worm) phosphatidylinositol 3 0.1723 0.3327 0.3327
Echinococcus multilocularis 0.0331 0.0608 0.0608
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0331 0.0608 0.0608
Trichomonas vaginalis PIKK family atypical protein kinase 0.3821 0.7427 0.7422
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0972 0.1859 0.1859
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0331 0.0608 0.059
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0056 0.007 0.007
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0331 0.0608 0.059
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0056 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0972 0.1859 0.1859
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0751 0.1428 0.1428
Trichomonas vaginalis PIKK family atypical protein kinase 0.4086 0.7946 0.7942
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0331 0.0608 0.0608
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0331 0.0608 0.0605
Trichomonas vaginalis PIKK family atypical protein kinase 0.3821 0.7427 0.7422
Trichomonas vaginalis PIKK family atypical protein kinase 0.2774 0.5381 0.5372
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0331 0.0608 0.0605
Trichomonas vaginalis PIKK family atypical protein kinase 0.0972 0.1859 0.1843
Giardia lamblia Phosphatidylinositol 4-kinase 0.0331 0.0608 0.0541
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0331 0.0608 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0331 0.0608 0.0608
Trichomonas vaginalis PIKK family atypical protein kinase 0.4386 0.8532 0.8529
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0056 0.007 0.0067
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0331 0.0608 0.0605
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0331 0.0608 0.0818
Loa Loa (eye worm) phosphatidylinositol kinase 0.0331 0.0608 0.0608
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.5137 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0331 0.0608 0.059
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1723 0.3327 0.3327
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0331 0.0608 0.059
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.0007 0.0007
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0331 0.0608 0.059
Brugia malayi p70 ribosomal S6 kinase beta 0.003 0.0019 0.0019
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0972 0.1859 0.1856
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.003 0.0019 0.0019
Schistosoma mansoni voltage-gated potassium channel 0.0167 0.0287 0.0287
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.003 0.0019 0.0019
Entamoeba histolytica hypothetical protein 0.0331 0.0608 0.0605
Loa Loa (eye worm) hypothetical protein 0.0049 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.1047 0.2006 0.2006
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0331 0.0608 0.0605
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.064 0.1211 0.1208
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.003 0.0019 0.0019
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0056 0.007 0.0051
Echinococcus multilocularis hyperpolarization activated cyclic 0.003 0.0019 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.1378 0.2654 0.264
Trichomonas vaginalis PIKK family atypical protein kinase 0.3039 0.59 0.5892
Loa Loa (eye worm) hypothetical protein 0.0751 0.1428 0.1428
Echinococcus multilocularis rac serine:threonine kinase 0.0022 0.0003 0.0003
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.003 0.0019 0.0019
Leishmania major phosphatidylinositol kinase, putative 0.0331 0.0608 0.0608
Trichomonas vaginalis PIKK family atypical protein kinase 0.1723 0.3327 0.3314
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0331 0.0608 0.0605
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0972 0.1859 0.1859
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.5137 1 1
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0056 0.007 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0972 0.1859 0.1843
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0047 0.0047
Entamoeba histolytica protein kinase rad3, putative 0.0972 0.1859 0.1856
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0056 0.007 0.0067
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1723 0.3327 0.3325
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1723 0.3327 0.3325
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0023 0.0004
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1083 0.2076 0.2795
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0049 0.0055 0.0055
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0056 0.007 0.007
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.003 0.0019 0.0019
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0153 0.0259 0.0259
Trichomonas vaginalis PIKK family atypical protein kinase 0.0331 0.0608 0.059
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0331 0.0608 0.0608
Schistosoma mansoni 60S ribosomal protein L21 0.0024 0.0007 0.0007
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0331 0.0608 0.0605
Brugia malayi FAT domain containing protein 0.0751 0.1428 0.1428
Trichomonas vaginalis PIKK family atypical protein kinase 0.307 0.5959 0.5951
Trichomonas vaginalis PIKK family atypical protein kinase 0.064 0.1211 0.1194
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0331 0.0608 0.0818
Trichomonas vaginalis PIKK family atypical protein kinase 0.277 0.5373 0.5364
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0331 0.0608 0.0605
Entamoeba histolytica hypothetical protein 0.0331 0.0608 0.0605
Mycobacterium leprae conserved hypothetical protein 0.0331 0.0608 0.5
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0056 0.007 0.007
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0331 0.0608 0.059
Trichomonas vaginalis PIKK family atypical protein kinase 0.3039 0.59 0.5892
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0056 0.007 0.0047
Leishmania major phosphatidylinositol 3-kinase, putative 0.0331 0.0608 0.0608
Trichomonas vaginalis PIKK family atypical protein kinase 0.3821 0.7427 0.7422
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0056 0.007 0.0051
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0331 0.0608 0.0605
Giardia lamblia GTOR 0.5137 1 1
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0972 0.1859 0.1859
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0331 0.0608 0.0608
Trichomonas vaginalis PIKK family atypical protein kinase 0.2774 0.5381 0.5372
Loa Loa (eye worm) phosphatidylinositol 3 0.0331 0.0608 0.0608
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0044 0.0047 0.0047
Mycobacterium tuberculosis Conserved hypothetical protein 0.0331 0.0608 0.5
Brugia malayi Protein kinase domain containing protein 0.0032 0.0023 0.0023
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0056 0.007 0.0067
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0331 0.0608 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0331 0.0608 0.0586
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0023 0.0004
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0023 0.0004
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0972 0.1859 0.1859
Loa Loa (eye worm) FKBP5 protein 0.0056 0.007 0.007
Trypanosoma brucei target of rapamycin kinase 3, putative 0.4091 0.7954 0.7949
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0331 0.0608 0.0605
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0331 0.0608 0.0608
Trichomonas vaginalis PIKK family atypical protein kinase 0.3821 0.7427 0.7422
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.5137 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0019 0.0019
Leishmania major hypothetical protein, unknown function 0.0331 0.0608 0.0608
Echinococcus granulosus voltage gated potassium channel 0.0044 0.0047 0.0047
Loa Loa (eye worm) phosphatidylinositol 3 0.0331 0.0608 0.0608
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0331 0.0608 0.0818
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0331 0.0608 0.0605
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0056 0.007 0.007
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.5137 1 1
Trypanosoma cruzi target of rapamycin kinase 3 0.4091 0.7954 0.7953
Schistosoma mansoni immunophilin 0.0056 0.007 0.007
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0056 0.007 0.0067
Loa Loa (eye worm) hypothetical protein 0.064 0.1211 0.1211
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0331 0.0608 0.0608
Trichomonas vaginalis PIKK family atypical protein kinase 0.0972 0.1859 0.1843
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.5137 1 1
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0331 0.0608 0.0608
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0331 0.0608 1
Echinococcus granulosus serine protein kinase ATM 0.0972 0.1859 0.1859
Trichomonas vaginalis PIKK family atypical protein kinase 0.1723 0.3327 0.3314
Loa Loa (eye worm) phosphatidylinositol 3 0.0331 0.0608 0.0608
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0331 0.0608 0.0608
Trichomonas vaginalis PIKK family atypical protein kinase 0.307 0.5959 0.5951
Trichomonas vaginalis PIKK family atypical protein kinase 0.277 0.5373 0.5364
Echinococcus multilocularis fk506 binding protein 0.0056 0.007 0.007
Plasmodium vivax hypothetical protein 0.0331 0.0608 1
Echinococcus granulosus serine/threonine protein kinase 0.0022 0.0003 0.0003
Echinococcus granulosus hyperpolarization activated cyclic 0.003 0.0019 0.0019
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1723 0.3327 0.3312
Trichomonas vaginalis immunophilin, putative 0.0056 0.007 0.0051
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.5137 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0331 0.0608 0.0608
Trichomonas vaginalis conserved hypothetical protein 0.064 0.1211 0.1194
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.5137 1 1
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.003 0.0019 0.0019
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0331 0.0608 1
Entamoeba histolytica protein kinase, putative 0.003 0.0019 0.0016
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0331 0.0608 0.059
Leishmania major phosphatidylinositol 3-kinase, putative 0.1723 0.3327 0.3327
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0331 0.0608 0.059
Entamoeba histolytica protein kinase, putative 0.0032 0.0023 0.002
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2134 0.413 0.4117
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0331 0.0608 0.0608
Onchocerca volvulus 0.0331 0.0608 0.5
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.003 0.0019 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.5137 1 1
Toxoplasma gondii AGC kinase 0.003 0.0019 0.0026
Schistosoma mansoni hypothetical protein 0.0331 0.0608 0.0608
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0331 0.0608 0.0818
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0972 0.1859 0.1859
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0331 0.0608 0.0605
Leishmania major phosphatidylinositol kinase related protein, putative 0.0331 0.0608 0.0608
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1723 0.3327 0.3327
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.003 0.0019 0.0019
Entamoeba histolytica hypothetical protein 0.0331 0.0608 0.0605
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0143 0.024 0.0221
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0056 0.007 0.007
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0331 0.0608 0.0608
Schistosoma mansoni voltage-gated potassium channel 0.0167 0.0287 0.0287
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0331 0.0608 0.0608
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.003 0.0019 0.0019

Activities

Activity type Activity value Assay description Source Reference
ILSmax (functional) = 25 % Tumor cell selectivity determined as maximal percent increase in life span (ILSmax) at LD10 dosage level in L1210 cells ChEMBL. 7120279
ILSmax (functional) = 25 % Tumor cell selectivity determined as maximal percent increase in life span (ILSmax) at LD10 dosage level in L1210 cells ChEMBL. 7120279
Log 1/D50 (functional) < 3.34 Drug concentration in mole/kg/day providing 50% extension of life in intraperitoneally implanted leukemia L1210 mice. ChEMBL. 7069706
Log 1/LD10 (ADMET) = 3.34 Compound concentration in mole/kg/day lethal to 10% of mice ChEMBL. 7069706

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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