Detailed information for compound 177378

Basic information

Technical information
  • TDR Targets ID: 177378
  • Name: N-[9-[4-(heptylsulfonylamino)-2-methoxyanilin o]acridin-3-yl]acetamide
  • MW: 534.67 | Formula: C29H34N4O4S
  • H donors: 3 H acceptors: 4 LogP: 6.06 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCCCCS(=O)(=O)Nc1ccc(c(c1)OC)Nc1c2ccccc2nc2c1ccc(c2)NC(=O)C
  • InChi: 1S/C29H34N4O4S/c1-4-5-6-7-10-17-38(35,36)33-22-14-16-26(28(19-22)37-3)32-29-23-11-8-9-12-25(23)31-27-18-21(30-20(2)34)13-15-24(27)29/h8-9,11-16,18-19,33H,4-7,10,17H2,1-3H3,(H,30,34)(H,31,32)
  • InChiKey: CSLYGYKGVZKOAV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[9-[4-(heptylsulfonylamino)-2-methoxy-anilino]acridin-3-yl]acetamide
  • N-[9-[4-(heptylsulfonylamino)-2-methoxyanilino]-3-acridinyl]acetamide
  • N-[9-[[4-(heptylsulfonylamino)-2-methoxy-phenyl]amino]acridin-3-yl]ethanamide
  • N-[9-[[4-(heptylsulfonylamino)-2-methoxyphenyl]amino]acridin-3-yl]acetamide
  • N-[9-[[4-(heptylsulfonylamino)-2-methoxy-phenyl]amino]acridin-3-yl]acetamide
  • N-[9-[[4-(heptylsulfonylamino)-2-methoxyphenyl]amino]-3-acridinyl]acetamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0694 0.1426 0.1422
Trichomonas vaginalis PIKK family atypical protein kinase 0.2835 0.5958 0.5956
Trichomonas vaginalis conserved hypothetical protein 0.0591 0.1209 0.1204
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0306 0.0606 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0022 0.0005 0.0004
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0306 0.0606 0.0605
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0306 0.0606 0.0601
Trichomonas vaginalis PIKK family atypical protein kinase 0.2807 0.5899 0.5897
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0057 0.0078 0.1278
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0306 0.0606 0.0601
Trichomonas vaginalis PIKK family atypical protein kinase 0.2558 0.5372 0.5369
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0306 0.0606 0.0605
Entamoeba histolytica hypothetical protein 0.0306 0.0606 0.0605
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0306 0.0606 0.0605
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0057 0.0078 0.0077
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0897 0.1857 0.1857
Trichomonas vaginalis PIKK family atypical protein kinase 0.2562 0.538 0.5378
Giardia lamblia Hypothetical protein 0.0306 0.0606 0.0605
Trichomonas vaginalis immunophilin, putative 0.0057 0.0078 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.3529 0.7427 0.7425
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0306 0.0606 0.0606
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.4745 1 1
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0306 0.0606 0.0606
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0306 0.0606 0.0601
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0049 0.0061 0.0061
Onchocerca volvulus 0.0306 0.0606 0.5
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0026 0.0021
Trichomonas vaginalis fk506-binding protein, putative 0.0057 0.0078 0.0072
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0306 0.0606 0.0606
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0005 0.0001
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0306 0.0606 0.0601
Brugia malayi FAT domain containing protein 0.0694 0.1426 0.1421
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.4745 1 1
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0057 0.0078 0.0072
Schistosoma mansoni fkbp-rapamycin associated protein 0.0897 0.1857 0.1853
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0306 0.0606 0.0606
Trichomonas vaginalis PIKK family atypical protein kinase 0.1591 0.3325 0.3322
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0897 0.1857 0.1857
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0057 0.0078 0.0077
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1591 0.3325 0.3273
Loa Loa (eye worm) phosphatidylinositol 3 0.1591 0.3325 0.3322
Loa Loa (eye worm) hypothetical protein 0.0033 0.0028 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0897 0.1857 0.1853
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0057 0.0078 0.0072
Schistosoma mansoni immunophilin 0.0049 0.0061 0.0057
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0026 0.0021
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0114 0.0199 0.0199
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0306 0.0606 0.0601
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0306 0.0606 0.0606
Brugia malayi Protein kinase domain containing protein 0.0032 0.0026 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.1 0.2074 0.207
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0306 0.0606 0.0601
Echinococcus multilocularis rac serine:threonine kinase 0.0022 0.0005 0.0005
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0023 0.0005 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0897 0.1857 0.1853
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0023 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0049 0.0061 0.0056
Entamoeba histolytica hypothetical protein 0.0306 0.0606 0.0605
Loa Loa (eye worm) hypothetical protein 0.0967 0.2004 0.2
Trichomonas vaginalis PIKK family atypical protein kinase 0.0591 0.1209 0.1204
Schistosoma mansoni voltage-gated potassium channel 0.0124 0.0221 0.0217
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0023 0.0005 0.0001
Mycobacterium tuberculosis Conserved hypothetical protein 0.0306 0.0606 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.1273 0.2652 0.2648
Trypanosoma cruzi Protein kinase B 0.0022 0.0005 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.2807 0.5899 0.5897
Echinococcus multilocularis fk506 binding protein 0.0057 0.0078 0.0078
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0023 0.0005 0.0005
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0694 0.1426 0.1426
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0306 0.0606 0.0601
Trichomonas vaginalis PIKK family atypical protein kinase 0.3774 0.7945 0.7944
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0306 0.0606 0.0605
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0897 0.1857 0.1857
Echinococcus multilocularis Zinc finger, PHD finger 0.0306 0.0606 0.0606
Trichomonas vaginalis PIKK family atypical protein kinase 0.2562 0.538 0.5378
Trichomonas vaginalis PIKK family atypical protein kinase 0.3529 0.7427 0.7425
Leishmania major phosphatidylinositol kinase, putative 0.0306 0.0606 0.0532
Entamoeba histolytica hypothetical protein 0.0306 0.0606 0.0605
Schistosoma mansoni hypothetical protein 0.0306 0.0606 0.0601
Loa Loa (eye worm) phosphatidylinositol kinase 0.0306 0.0606 0.0601
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.4745 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1591 0.3325 0.3308
Loa Loa (eye worm) hypothetical protein 0.0306 0.0606 0.0601
Trichomonas vaginalis PIKK family atypical protein kinase 0.4051 0.8532 0.8531
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0306 0.0606 0.0605
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0057 0.0078 0.0077
Loa Loa (eye worm) phosphatidylinositol 3 0.0306 0.0606 0.0601
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0306 0.0606 0.0788
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.4745 1 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0023 0.0005 0.0005
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0306 0.0606 1
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0306 0.0606 0.0606
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0023 0.0005 0.0005
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0306 0.0606 0.0605
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1591 0.3325 0.3325
Trichomonas vaginalis PIKK family atypical protein kinase 0.0897 0.1857 0.1853
Entamoeba histolytica hypothetical protein 0.0306 0.0606 0.0605
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0306 0.0606 0.0605
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0023 0.0005 0.0005
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0306 0.0606 0.0788
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0107 0.0183 0.0178
Echinococcus granulosus serine/threonine protein kinase 0.0022 0.0005 0.0005
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0057 0.0078 0.0072
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0306 0.0606 0.0601
Schistosoma mansoni voltage-gated potassium channel 0.0124 0.0221 0.0217
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0306 0.0606 0.0605
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0057 0.0078 0.0072
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0306 0.0606 0.0601
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0591 0.1209 0.1209
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0057 0.0078 0.0078
Entamoeba histolytica PH domain containing protein kinase, putative 0.0022 0.0005 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.1591 0.3325 0.3322
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.4745 1 1
Loa Loa (eye worm) hypothetical protein 0.0306 0.0606 0.0601
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0306 0.0606 0.0601
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.4745 1 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0023 0.0005 0.0005
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0306 0.0606 0.0532
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.003 0.0022 0.0017
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1971 0.4129 0.4113
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0306 0.0606 0.0601
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1591 0.3325 0.3322
Trichomonas vaginalis PIKK family atypical protein kinase 0.0306 0.0606 0.0601
Schistosoma mansoni voltage-gated potassium channel 0.0033 0.0028 0.0023
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0057 0.0078 0.0077
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0057 0.0078 0.0077
Trypanosoma cruzi target of rapamycin kinase 3 0.3778 0.7954 0.7953
Loa Loa (eye worm) hypothetical protein 0.0591 0.1209 0.1204
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0306 0.0606 0.0605
Echinococcus granulosus serine protein kinase ATM 0.0897 0.1857 0.1857
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0306 0.0606 0.0601
Leishmania major phosphatidylinositol kinase related protein, putative 0.0306 0.0606 0.0532
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.4745 1 1
Loa Loa (eye worm) hypothetical protein 0.0897 0.1857 0.1853
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0306 0.0606 0.0601
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1591 0.3325 0.3325
Trichomonas vaginalis PIKK family atypical protein kinase 0.2835 0.5958 0.5956
Leishmania major hypothetical protein, unknown function 0.0306 0.0606 0.0532
Trichomonas vaginalis PIKK family atypical protein kinase 0.2558 0.5372 0.5369
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0057 0.0078 0.0052
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.3778 0.7954 0.7937
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0306 0.0606 0.0605
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0026 0.0021
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0026 0.0021
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0897 0.1857 0.1853
Trichomonas vaginalis PIKK family atypical protein kinase 0.3529 0.7427 0.7425
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0306 0.0606 0.0601
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0033 0.0028 0.0022
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0306 0.0606 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0306 0.0606 0.0601
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0306 0.0606 0.0601
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0306 0.0606 0.0605
Trichomonas vaginalis PIKK family atypical protein kinase 0.4745 1 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0023 0.0005 0.0001
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0057 0.0078 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.4745 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0306 0.0606 0.0601
Entamoeba histolytica protein kinase, putative 0.0032 0.0026 0.0026
Trypanosoma brucei target of rapamycin kinase 3, putative 0.3778 0.7954 0.7948
Echinococcus granulosus hyperpolarization activated cyclic 0.0023 0.0005 0.0005
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0114 0.0199 0.0199
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0306 0.0606 1
Loa Loa (eye worm) AGC/AKT protein kinase 0.0032 0.0026 0.0021
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0306 0.0606 0.0605
Loa Loa (eye worm) phosphatidylinositol 3 0.0306 0.0606 0.0601
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0057 0.0078 0.0077
Echinococcus multilocularis 0.0306 0.0606 0.0606
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0897 0.1857 0.1857
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0306 0.0606 0.0581
Echinococcus multilocularis serine protein kinase ATM 0.0897 0.1857 0.1857
Trichomonas vaginalis PIKK family atypical protein kinase 0.3774 0.7945 0.7944
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0306 0.0606 0.0606
Onchocerca volvulus 0.0306 0.0606 0.5
Echinococcus granulosus voltage gated potassium channel 0.0033 0.0028 0.0028
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0306 0.0606 0.0606
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0057 0.0078 0.5
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1591 0.3325 0.3325
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0023 0.0005 0.0005
Leishmania major phosphatidylinositol 3-kinase, putative 0.1591 0.3325 0.3273
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1591 0.3325 0.3322
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0306 0.0606 0.0601
Trichomonas vaginalis PIKK family atypical protein kinase 0.3774 0.7945 0.7944
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0114 0.0199 0.0194
Trichomonas vaginalis PIKK family atypical protein kinase 0.2835 0.5958 0.5956
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1591 0.3325 0.3325
Trichomonas vaginalis PIKK family atypical protein kinase 0.0306 0.0606 0.0601
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.4745 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0306 0.0606 0.0601
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0306 0.0606 0.0606
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0026 0.0021
Schistosoma mansoni immunophilin 0.0057 0.0078 0.0073
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0306 0.0606 0.0605
Loa Loa (eye worm) phosphatidylinositol 3 0.4745 1 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.4745 1 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0033 0.0028 0.0028
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1591 0.3325 0.3308
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0306 0.0606 0.0601
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0057 0.0078 0.0078
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.4745 1 1
Brugia malayi p70 ribosomal S6 kinase beta 0.003 0.0022 0.0017
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0306 0.0606 0.0788
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0057 0.0078 0.0073
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0306 0.0606 0.0601
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0114 0.0199 0.0194
Trichomonas vaginalis PIKK family atypical protein kinase 0.308 0.6477 0.6475
Trichomonas vaginalis PIKK family atypical protein kinase 0.1591 0.3325 0.3322
Entamoeba histolytica protein kinase, putative 0.003 0.0022 0.0022
Plasmodium vivax hypothetical protein 0.0306 0.0606 1
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0306 0.0606 0.0581
Trichomonas vaginalis PIKK family atypical protein kinase 0.1591 0.3325 0.3322
Entamoeba histolytica protein kinase, putative 0.0032 0.0026 0.0026
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0897 0.1857 0.1836
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0023 0.0005 0.0001
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0306 0.0606 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2562 0.538 0.5378
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0306 0.0606 0.0601
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0306 0.0606 0.0601
Leishmania major phosphatidylinositol 4-kinase, putative 0.0306 0.0606 0.0532
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0897 0.1857 0.1857
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0306 0.0606 0.0601
Leishmania major phosphatidylinositol 3-kinase, putative 0.0306 0.0606 0.0532
Trichomonas vaginalis PIKK family atypical protein kinase 0.4745 1 1
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0306 0.0606 0.0601
Loa Loa (eye worm) phosphatidylinositol 3 0.0306 0.0606 0.0601
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2244 0.4707 0.4693
Trichomonas vaginalis PIKK family atypical protein kinase 0.3774 0.7945 0.7944
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0057 0.0078 0.0052
Schistosoma mansoni voltage-gated potassium channel 0.0033 0.0028 0.0023
Giardia lamblia Phosphatidylinositol 4-kinase 0.0306 0.0606 0.0605
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0023 0.0005 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.2558 0.5372 0.5369
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0306 0.0606 1
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0306 0.0606 0.0606
Loa Loa (eye worm) hypothetical protein 0.0099 0.0167 0.0162
Trichomonas vaginalis PIKK family atypical protein kinase 0.2562 0.538 0.5378
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0306 0.0606 0.0605
Trichomonas vaginalis PIKK family atypical protein kinase 0.3774 0.7945 0.7944
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0897 0.1857 0.1853
Trichomonas vaginalis PIKK family atypical protein kinase 0.1591 0.3325 0.3322
Toxoplasma gondii FATC domain-containing protein 0.0897 0.1857 0.2478
Toxoplasma gondii target of rapamycin (TOR), putative 0.3529 0.7427 1
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0306 0.0606 0.0606
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0306 0.0606 0.0601
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0897 0.1857 0.1853
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0306 0.0606 0.0605
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0057 0.0078 0.1278
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0306 0.0606 0.0606
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0057 0.0078 0.0078
Echinococcus granulosus hyperpolarization activated cyclic 0.0023 0.0005 0.0005
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0057 0.0078 0.5
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0023 0.0005 0.0001
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0049 0.0061 0.0061
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0306 0.0606 1
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0306 0.0606 0.0606
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0033 0.0028 0.0028
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0057 0.0078 0.0077
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0306 0.0606 0.0605
Entamoeba histolytica protein kinase rad3, putative 0.0897 0.1857 0.1857
Loa Loa (eye worm) hypothetical protein 0.0694 0.1426 0.1421
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0057 0.0078 0.0077
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.4745 1 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1 0.2074 0.2771
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0306 0.0606 0.0606
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0306 0.0606 0.0605
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0026 0.0021
Echinococcus multilocularis voltage gated potassium channel 0.0033 0.0028 0.0028
Mycobacterium leprae conserved hypothetical protein 0.0306 0.0606 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0306 0.0606 0.0601
Schistosoma mansoni immunophilin 0.0057 0.0078 0.0073
Loa Loa (eye worm) phosphatidylinositol 3 0.0306 0.0606 0.0601
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0306 0.0606 0.0788
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0306 0.0606 0.0605
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0022 0.0005 0.0004
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0306 0.0606 0.0581
Trichomonas vaginalis PIKK family atypical protein kinase 0.3529 0.7427 0.7425
Trichomonas vaginalis PIKK family atypical protein kinase 0.3529 0.7427 0.7425
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0026 0.0021
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0306 0.0606 0.0601
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0306 0.0606 0.0581
Trichomonas vaginalis PIKK family atypical protein kinase 0.3529 0.7427 0.7425
Trichomonas vaginalis conserved hypothetical protein 0.0694 0.1426 0.1421
Trichomonas vaginalis PIKK family atypical protein kinase 0.3183 0.6694 0.6692
Trichomonas vaginalis PIKK family atypical protein kinase 0.3529 0.7427 0.7425
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0306 0.0606 0.0601
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0107 0.0183 0.0178
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0306 0.0606 0.0788
Loa Loa (eye worm) FKBP5 protein 0.0057 0.0078 0.0072
Giardia lamblia GTOR 0.4745 1 1
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0023 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.1 0.2074 0.207
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0306 0.0606 0.0605
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0694 0.1426 0.1426
Plasmodium vivax hypothetical protein, conserved 0.0306 0.0606 1
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0306 0.0606 0.0605
Leishmania major hypothetical protein, conserved 0.0306 0.0606 0.0532
Entamoeba histolytica hypothetical protein 0.0897 0.1857 0.1857

Activities

Activity type Activity value Assay description Source Reference
Log 1/D50 (functional) = 4.55 Drug concentration in mole/kg/day providing 50% extension of life in intraperitoneally implanted leukemia L1210 mice. ChEMBL. 7069706
Log 1/LD10 (ADMET) = 4.31 Compound concentration in mole/kg/day lethal to 10% of mice ChEMBL. 7069706

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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