TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 337.372 | Formula: C19H19N3O3
H donors: 1 H acceptors: 3 LogP: 2.33 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: N#C[C@@H]1CCCN1C(=O)CNC(=O)COc1cccc2c1cccc2
InChi: 1S/C19H19N3O3/c20-11-15-7-4-10-22(15)19(24)12-21-18(23)13-25-17-9-3-6-14-5-1-2-8-16(14)17/h1-3,5-6,8-9,15H,4,7,10,12-13H2,(H,21,23)/t15-/m0/s1
InChiKey: VRVJKJRGXAIUNH-HNNXBMFYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	fibroblast activation protein	Starlite/ChEMBL	References
Homo sapiens	prolyl endopeptidase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K01278 dipeptidyl-peptidase 4, putative	Get druggable targets OG5_128614	All targets in OG5_128614
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	Get druggable targets OG5_129295	All targets in OG5_129295
Trypanosoma brucei gambiense	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	Get druggable targets OG5_129295	All targets in OG5_129295
Candida albicans	dipeptidyl aminopeptidase B	Get druggable targets OG5_128614	All targets in OG5_128614
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	Get druggable targets OG5_129295	All targets in OG5_129295
Brugia malayi	prolyl oligopeptidase family protein	Get druggable targets OG5_129295	All targets in OG5_129295
Leishmania mexicana	prolyl oligopeptidase, putative	Get druggable targets OG5_129295	All targets in OG5_129295
Schistosoma japonicum	ko:K01322 prolyl oligopeptidase [EC3.4.21.26], putative	Get druggable targets OG5_129295	All targets in OG5_129295
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	Get druggable targets OG5_128614	All targets in OG5_128614
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129295	All targets in OG5_129295
Leishmania major	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	Get druggable targets OG5_129295	All targets in OG5_129295
Trypanosoma brucei	prolyl endopeptidase	Get druggable targets OG5_129295	All targets in OG5_129295
Toxoplasma gondii	prolyl endopeptidase	Get druggable targets OG5_129295	All targets in OG5_129295
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	Get druggable targets OG5_128614	All targets in OG5_128614
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	Get druggable targets OG5_128614	All targets in OG5_128614
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	Get druggable targets OG5_128614	All targets in OG5_128614
Trypanosoma cruzi	prolyl endopeptidase	Get druggable targets OG5_129295	All targets in OG5_129295
Onchocerca volvulus	Prolyl endopeptidase homolog	Get druggable targets OG5_129295	All targets in OG5_129295
Neospora caninum	Prolyl oligopeptidase (EC 3.4.21.26) (Precursor), related	Get druggable targets OG5_129295	All targets in OG5_129295
Trypanosoma congolense	prolyl endopeptidase	Get druggable targets OG5_129295	All targets in OG5_129295
Loa Loa (eye worm)	prolyl oligopeptidase	Get druggable targets OG5_128614	All targets in OG5_128614
Leishmania infantum	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	Get druggable targets OG5_129295	All targets in OG5_129295
Mycobacterium tuberculosis	Probable protease II PtrBa [first part] (oligopeptidase B)	Get druggable targets OG5_129295	All targets in OG5_129295
Leishmania donovani	prolyl endopeptidase	Get druggable targets OG5_129295	All targets in OG5_129295
Echinococcus granulosus	prolyl endopeptidase	Get druggable targets OG5_129295	All targets in OG5_129295
Candida albicans	dipeptidyl aminopeptidase B	Get druggable targets OG5_128614	All targets in OG5_128614
Echinococcus multilocularis	prolyl endopeptidase	Get druggable targets OG5_129295	All targets in OG5_129295
Brugia malayi	prolyl oligopeptidase family protein	Get druggable targets OG5_128614	All targets in OG5_128614
Schistosoma japonicum	Prolyl endopeptidase, putative	Get druggable targets OG5_129295	All targets in OG5_129295

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	oligopeptidase b	prolyl endopeptidase	710 aa	630 aa	27.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0456	0.0537
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0038	0.0456	0.0537
Echinococcus granulosus	dna polymerase eta	0.0052	0.0737	0.0711
Echinococcus multilocularis	dro:myosuppressin receptor	0.0038	0.0456	0.043
Echinococcus multilocularis	allatostatin A receptor	0.0038	0.0456	0.043
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.0087	0.1413	0.4328
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Echinococcus granulosus	orexin receptor type 2	0.0038	0.0456	0.043
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0038	0.0456	0.0537
Brugia malayi	AKH receptor	0.0038	0.0456	0.0361
Plasmodium vivax	hypothetical protein, conserved	0.0033	0.0364	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0038	0.0456	0.043
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0033	0.0364	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0364	0.0263
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0038	0.0456	0.043
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0157	0.0439
Loa Loa (eye worm)	G-protein coupled receptor	0.0038	0.0456	0.0356
Schistosoma mansoni	cpg binding protein	0.0068	0.1037	0.1248
Echinococcus multilocularis	G protein coupled receptor 139	0.0038	0.0456	0.043
Echinococcus granulosus	neuropeptides capa receptor	0.0038	0.0456	0.043
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0038	0.0456	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Schistosoma mansoni	ap endonuclease	0.002	0.0107	0.0109
Brugia malayi	follicle stimulating hormone receptor	0.0038	0.0456	0.0361
Schistosoma mansoni	cpg binding protein	0.0064	0.0966	0.1161
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0456	0.043
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0038	0.0456	0.0361
Leishmania major	DNA polymerase eta, putative	0.0037	0.0434	0.1084
Echinococcus multilocularis	fmrfamide receptor	0.0038	0.0456	0.043
Toxoplasma gondii	hypothetical protein	0.0033	0.0364	0.1116
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.0087	0.1413	0.1389
Echinococcus granulosus	neuropeptide Y receptor	0.0038	0.0456	0.043
Echinococcus granulosus	biogenic amine 5HT receptor	0.0038	0.0456	0.043
Schistosoma mansoni	hypothetical protein	0.0038	0.0456	0.0537
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0136	0.2366	0.2874
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0038	0.0456	0.0356
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.0107	0.0079
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0456	0.043
Trypanosoma brucei	prolyl oligopeptidase, putative	0.0079	0.1267	0.4016
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0038	0.0456	0.043
Brugia malayi	hypothetical protein	0.0038	0.0456	0.0361
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0033	0.0364	1
Echinococcus multilocularis	cpg binding protein	0.0068	0.1037	0.1013
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Echinococcus multilocularis	serotonin receptor	0.0038	0.0456	0.043
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0226	0.4122	0.4106
Mycobacterium ulcerans	protease II (oligopeptidase B), PtrB	0.0079	0.1267	1
Trypanosoma cruzi	DNA polymerase eta, putative	0.0037	0.0434	0.1084
Brugia malayi	hypothetical protein	0.0038	0.0456	0.0361
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0456	0.0537
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0456	0.043
Echinococcus multilocularis	Alpha N acetylgalactosaminidase	0.0109	0.1838	0.1816
Toxoplasma gondii	prolyl endopeptidase	0.0175	0.3125	1
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0023	0.0157	0.1384
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0226	0.4122	0.5024
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Echinococcus granulosus	7TM GPCR rhodopsin	0.0038	0.0456	0.043
Schistosoma mansoni	opsin-like receptor	0.0038	0.0456	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Brugia malayi	putative neuropeptide receptor NPR1	0.0038	0.0456	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Leishmania major	oligopeptidase b	0.0079	0.1267	0.3845
Echinococcus granulosus	g-protein coupled receptor	0.0038	0.0456	0.043
Echinococcus granulosus	g protein coupled receptor	0.0038	0.0456	0.043
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0157	0.0439
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0038	0.0456	0.043
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0.0107	0.5
Entamoeba histolytica	dipeptidyl-peptidase, putative	0.0033	0.0364	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0456	0.043
Echinococcus multilocularis	Glycoside hydrolase, family 27	0.0109	0.1838	0.1816
Echinococcus granulosus	G protein coupled receptor 139	0.0038	0.0456	0.043
Echinococcus granulosus	dro:myosuppressin receptor	0.0038	0.0456	0.043
Echinococcus multilocularis	g protein coupled receptor	0.0038	0.0456	0.043
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0456	0.043
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0038	0.0456	0.043
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0038	0.0456	0.043
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0038	0.0456	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0226	0.4122	0.4106
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0038	0.0456	0.043
Schistosoma mansoni	neuropeptide F-like receptor	0.0038	0.0456	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Loa Loa (eye worm)	TYRA-2 protein	0.0038	0.0456	0.0356
Schistosoma mansoni	hypothetical protein	0.0038	0.0456	0.0537
Brugia malayi	prolyl oligopeptidase family protein	0.0226	0.4122	0.4064
Echinococcus granulosus	biogenic amine 5HT receptor	0.0038	0.0456	0.043
Echinococcus multilocularis	g-protein coupled receptor	0.0038	0.0456	0.043
Toxoplasma gondii	exonuclease III APE	0.002	0.0107	0.0287
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0108	0.1814	0.1733
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0456	0.043
Brugia malayi	Dopamine receptor protein 2	0.0038	0.0456	0.0361
Trypanosoma cruzi	hypothetical protein, conserved	0.0033	0.0364	0.0853
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0157	0.0439
Toxoplasma gondii	acylaminoacyl-peptidase, putative	0.0033	0.0364	0.1116
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0456	0.0537
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0038	0.0456	0.043
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Echinococcus multilocularis	orexin receptor type 2	0.0038	0.0456	0.043
Echinococcus multilocularis	neuropeptide Y receptor	0.0038	0.0456	0.043
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.0087	0.1413	0.4328
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0038	0.0456	0.0537
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.002	0.0103	0.0076
Leishmania major	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	0.0175	0.3125	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0033	0.0364	0.0853
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0038	0.0456	0.043
Brugia malayi	Dopamine receptor	0.0038	0.0456	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Entamoeba histolytica	dipeptidyl-peptidase, putative	0.0033	0.0364	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0038	0.0456	0.0356
Echinococcus granulosus	dnaJ subfamily B	0.0434	0.8188	0.8183
Schistosoma mansoni	biogenic amine receptor	0.0038	0.0456	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0175	0.3125	0.3053
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0175	0.3125	0.3803
Brugia malayi	G protein-coupled receptor	0.0038	0.0456	0.0361
Echinococcus multilocularis	acylamino acid releasing enzyme	0.0033	0.0364	0.0338
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0038	0.0456	0.0356
Schistosoma mansoni	amine GPCR	0.0038	0.0456	0.0537
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0107	0.0942
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	0.0087	0.1413	0.4328
Leishmania major	oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein	0.0079	0.1267	0.3845
Loa Loa (eye worm)	cytochrome P450 family protein	0.0052	0.0727	0.063
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0157	0.0439
Echinococcus multilocularis	neuropeptides capa receptor	0.0038	0.0456	0.043
Trypanosoma cruzi	DNA polymerase eta, putative	0.0052	0.0737	0.2088
Brugia malayi	neuropeptide F receptor	0.0038	0.0456	0.0361
Trichomonas vaginalis	Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase	0.0033	0.0364	0.3217
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0157	0.0439
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0157	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Trypanosoma cruzi	oligopeptidase b	0.0079	0.1267	0.3845
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0023	0.0157	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Echinococcus granulosus	g protein coupled receptor	0.0038	0.0456	0.043
Brugia malayi	hypothetical protein	0.0038	0.0456	0.0361
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0023	0.0157	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0364	0.0263
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0038	0.0456	0.0537
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0038	0.0456	0.0361
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0038	0.0456	0.043
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0023	0.0157	0.0211
Loa Loa (eye worm)	G-protein coupled receptor	0.0038	0.0456	0.0356
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0456	0.043
Schistosoma mansoni	amine GPCR	0.0038	0.0456	0.0537
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0038	0.0456	0.043
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0456	0.043
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0038	0.0456	0.043
Brugia malayi	hypothetical protein	0.0038	0.0456	0.0361
Echinococcus granulosus	neuropeptide receptor	0.0038	0.0456	0.043
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0456	0.0537
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0038	0.0456	0.0537
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0073	0.1132	0.1364
Onchocerca volvulus		0.0064	0.0966	0.1391
Echinococcus multilocularis	neuropeptide receptor	0.0038	0.0456	0.043
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0456	0.043
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0023	0.0157	0.017
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0157	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Echinococcus multilocularis	fmrfamide receptor	0.0038	0.0456	0.043
Schistosoma mansoni	amine GPCR	0.0038	0.0456	0.0537
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0038	0.0456	0.043
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.0087	0.1413	0.4486
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0038	0.0456	0.043
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.002	0.0103	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Brugia malayi	CXXC zinc finger family protein	0.0064	0.0966	0.0876
Echinococcus granulosus	neuropeptides capa receptor	0.0038	0.0456	0.043
Echinococcus granulosus	somatostatin receptor	0.0038	0.0456	0.043
Giardia lamblia	DINP protein human, muc B family	0.0023	0.0157	0.1942
Brugia malayi	Serotonin receptor	0.0038	0.0456	0.0361
Echinococcus granulosus	hypothetical protein	0.0038	0.0456	0.043
Echinococcus multilocularis	dna polymerase eta	0.0052	0.0737	0.0711
Brugia malayi	hypothetical protein	0.0038	0.0456	0.0361
Echinococcus granulosus	survival motor neuron protein 1	0.0527	1	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0038	0.0456	0.043
Brugia malayi	Melatonin receptor type 1A	0.0038	0.0456	0.0361
Schistosoma mansoni	growth hormone secretagogue receptor	0.0038	0.0456	0.0537
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0038	0.0456	0.0537
Echinococcus granulosus	prolyl endopeptidase	0.0175	0.3125	0.3106
Schistosoma mansoni	hypothetical protein	0.0038	0.0456	0.0537
Brugia malayi	larval opioid receptor	0.0038	0.0456	0.0361
Schistosoma mansoni	acylaminoacyl-peptidase (S09 family)	0.0033	0.0364	0.0424
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1132	0.1039
Echinococcus granulosus	Dipeptidyl peptidase 9	0.0087	0.1413	0.1389
Echinococcus multilocularis	prolyl endopeptidase	0.0175	0.3125	0.3106
Trichomonas vaginalis	alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative	0.0073	0.1132	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0038	0.0456	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Trichomonas vaginalis	DNA polymerase eta, putative	0.0023	0.0157	0.1384
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0038	0.0456	0.043
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.002	0.0107	0.0278
Schistosoma mansoni	amine GPCR	0.0038	0.0456	0.0537
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0038	0.0456	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0109	0.1838	0.2229
Schistosoma mansoni	biogenic amine receptor	0.0038	0.0456	0.0537
Loa Loa (eye worm)	melatonin receptor type 1A	0.0038	0.0456	0.0356
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0038	0.0456	0.0361
Trypanosoma brucei	serine peptidase, clan SC, family S9A-like protein	0.0079	0.1267	0.4016
Schistosoma mansoni	cpg binding protein	0.0068	0.1037	0.1248
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0038	0.0456	0.0537
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0456	0.0537
Loa Loa (eye worm)	neuropeptide F receptor	0.0038	0.0456	0.0356
Brugia malayi	prolyl oligopeptidase family protein	0.0175	0.3125	0.3057
Echinococcus multilocularis	neuropeptide receptor A26	0.0526	0.9984	0.9984
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0023	0.0157	0.0166
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0456	0.0537
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.0107	0.0008
Schistosoma mansoni	neuropeptide F-like receptor	0.0038	0.0456	0.0537
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.0087	0.1413	0.4486
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0157	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0766	0.0669
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0038	0.0456	0.043
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Echinococcus multilocularis	neuropeptide receptor	0.0038	0.0456	0.043
Loa Loa (eye worm)	prolyl oligopeptidase	0.0033	0.0364	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Brugia malayi	G-protein coupled receptor	0.0038	0.0456	0.0361
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0023	0.0157	0.013
Giardia lamblia	Alanyl dipeptidyl peptidase	0.0033	0.0364	1
Schistosoma mansoni	survival motor neuron protein	0.0108	0.1814	0.2199
Echinococcus granulosus	fmrfamide receptor	0.0038	0.0456	0.043
Brugia malayi	Melibiase family protein	0.0073	0.1132	0.1043
Echinococcus granulosus	allatostatin A receptor	0.0038	0.0456	0.043
Brugia malayi	putative neuropeptide receptor	0.0038	0.0456	0.0361
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0157	0.0166
Loa Loa (eye worm)	neuropeptide F receptor	0.0038	0.0456	0.0356
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0456	0.043
Echinococcus granulosus	dna polymerase kappa	0.0023	0.0157	0.013
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Mycobacterium ulcerans	DNA polymerase IV	0.0023	0.0157	0.0431
Echinococcus granulosus	acylamino acid releasing enzyme	0.0033	0.0364	0.0338
Echinococcus granulosus	Alpha N acetylgalactosaminidase	0.0109	0.1838	0.1816
Brugia malayi	hypothetical protein	0.0038	0.0456	0.0361
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.0226	0.4122	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0157	0.0439
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0157	0.0439
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0038	0.0456	0.0356
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0038	0.0456	0.043
Treponema pallidum	exodeoxyribonuclease (exoA)	0.002	0.0107	0.5
Schistosoma mansoni	opsin-like receptor	0.0038	0.0456	0.0537
Leishmania major	DNA polymerase eta, putative	0.0052	0.0737	0.2088
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0456	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.0107	0.0079
Schistosoma mansoni	myosin xvIII	0.0038	0.0456	0.0537
Brugia malayi	ImpB/MucB/SamB family protein	0.0052	0.0737	0.0645
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0023	0.0157	0.013
Trypanosoma brucei	Alpha/beta hydrolase domain-containing protein	0.0033	0.0364	0.1108
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Giardia lamblia	Alanyl dipeptidyl peptidase	0.0033	0.0364	1
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0107	0.0942
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Echinococcus granulosus	cpg binding protein	0.0068	0.1037	0.1013
Echinococcus granulosus	neuropeptide receptor	0.0038	0.0456	0.043
Echinococcus multilocularis	neuropeptides capa receptor	0.0038	0.0456	0.043
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0023	0.0157	0.017
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0456	0.043
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Brugia malayi	G-protein coupled receptor	0.0038	0.0456	0.0361
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0038	0.0456	0.0537
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0038	0.0456	0.0537
Echinococcus multilocularis	neuropeptide Y receptor	0.0038	0.0456	0.043
Echinococcus multilocularis	g protein coupled receptor	0.0038	0.0456	0.043
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Trypanosoma cruzi	oligopeptidase b	0.0079	0.1267	0.3845
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0737	0.064
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0033	0.0364	1
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0064	0.0966	0.0871
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0175	0.3125	0.3803
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0157	0.0166
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0038	0.0456	0.043
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0038	0.0456	0.043
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0364	0.3217
Echinococcus granulosus	7tm_1 domain containing protein	0.0038	0.0456	0.043
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0023	0.0157	0.1942
Leishmania major	DNA polymerase kappa, putative	0.0023	0.0157	0.0166
Echinococcus granulosus	tm gpcr rhodopsin	0.0038	0.0456	0.043
Trypanosoma brucei	unspecified product	0.0023	0.0157	0.0439
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0038	0.0456	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0033	0.0364	0.0424
Schistosoma mansoni	DNA polymerase eta	0.0052	0.0737	0.088
Brugia malayi	sulfakinin receptor protein	0.0038	0.0456	0.0361
Brugia malayi	Dopamine receptor protein 1	0.0038	0.0456	0.0361
Schistosoma mansoni	histamine h1 receptor	0.0038	0.0456	0.0537
Echinococcus granulosus	neuropeptide Y receptor	0.0038	0.0456	0.043
Echinococcus granulosus	neuropeptide FF receptor 2	0.0038	0.0456	0.043
Echinococcus multilocularis	serotonin receptor	0.0038	0.0456	0.043
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0456	0.0537
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0038	0.0456	0.043
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0456	0.0537
Echinococcus granulosus	tm gpcr rhodopsin	0.0038	0.0456	0.043
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0037	0.0434	0.134
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0456	0.0537
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0038	0.0456	0.0537
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0456	0.043
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Brugia malayi	hypothetical protein	0.0038	0.0456	0.0361
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0157	0.0166
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0157	0.0439
Brugia malayi	ORL1-like opioid receptor	0.0038	0.0456	0.0361
Mycobacterium tuberculosis	Probable protease II PtrBa [first part] (oligopeptidase B)	0.0142	0.2478	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0456	0.043
Schistosoma mansoni	hypothetical protein	0.0038	0.0456	0.0537
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0038	0.0456	0.0537
Echinococcus multilocularis	g protein coupled receptor	0.0038	0.0456	0.043
Trypanosoma brucei	DNA polymerase eta, putative	0.0052	0.0737	0.2308
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0038	0.0456	0.0361
Brugia malayi	hypothetical protein	0.0054	0.0766	0.0674
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0157	0.0439
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0038	0.0456	0.043
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0109	0.1838	0.2229
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0109	0.1838	0.2229
Trypanosoma cruzi	prolyl endopeptidase	0.0175	0.3125	1
Echinococcus multilocularis	survival motor neuron protein 1	0.0527	1	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0157	0.0439
Brugia malayi	prolyl oligopeptidase family protein	0.0033	0.0364	0.0268
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.0087	0.1413	0.1708
Toxoplasma gondii	dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein	0.0087	0.1413	0.4491
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0109	0.1838	0.2229
Echinococcus multilocularis	neuropeptide s receptor	0.0526	0.9984	0.9984
Brugia malayi	Cytochrome P450 family protein	0.0052	0.0727	0.0635
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0033	0.0364	0.3217
Mycobacterium ulcerans	DNA polymerase IV	0.0023	0.0157	0.0431
Schistosoma mansoni	neuropeptide f receptor 76f	0.0038	0.0456	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Echinococcus granulosus	serotonin receptor	0.0038	0.0456	0.043
Echinococcus granulosus	sex peptide receptor	0.0038	0.0456	0.043
Brugia malayi	Serotonin receptor	0.0038	0.0456	0.0361
Plasmodium falciparum	peptidase, putative	0.0033	0.0364	1
Schistosoma mansoni	hypothetical protein	0.0434	0.8188	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Schistosoma mansoni	biogenic amine receptor	0.0038	0.0456	0.0537
Echinococcus multilocularis	sex peptide receptor	0.0038	0.0456	0.043
Loa Loa (eye worm)	prolyl oligopeptidase	0.0226	0.4122	0.4061
Loa Loa (eye worm)	hypothetical protein	0.0527	1	1
Echinococcus multilocularis	dnaJ subfamily B	0.0434	0.8188	0.8183
Brugia malayi	RE15519p	0.0038	0.0456	0.0361
Brugia malayi	hypothetical protein	0.0038	0.0456	0.0361
Echinococcus granulosus	neuropeptide receptor A26	0.0526	0.9984	0.9984
Mycobacterium tuberculosis	Probable peptidase	0.0079	0.1267	0.4894
Brugia malayi	ImpB/MucB/SamB family protein	0.0023	0.0157	0.0059
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0038	0.0456	0.0356
Brugia malayi	GnHR receptor homolog	0.0038	0.0456	0.0361
Echinococcus granulosus	tm gpcr rhodopsin	0.0038	0.0456	0.043
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0157	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Brugia malayi	hypothetical protein	0.0038	0.0456	0.0361
Schistosoma mansoni	ap endonuclease	0.002	0.0107	0.0109
Toxoplasma gondii	melibiase subfamily protein	0.0109	0.1838	0.586
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.0107	0.0003
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0038	0.0456	0.0361
Echinococcus multilocularis	dna polymerase kappa	0.0023	0.0157	0.013
Schistosoma mansoni	opsin-like receptor	0.0038	0.0456	0.0537
Brugia malayi	G protein-coupled receptor F59B2.13	0.0038	0.0456	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Entamoeba histolytica	hypothetical protein, conserved	0.0033	0.0364	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0456	0.0537
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0016	0.0027	0.0012
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0121	0.2083	0.6647
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0038	0.0456	0.043
Schistosoma mansoni	adenoreceptor	0.0038	0.0456	0.0537
Mycobacterium leprae	PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B)	0.0079	0.1267	0.5
Brugia malayi	neuropeptide F receptor	0.0038	0.0456	0.0361
Echinococcus granulosus	g protein coupled receptor	0.0038	0.0456	0.043
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0073	0.1132	0.1364
Schistosoma mansoni	hypothetical protein	0.0108	0.1814	0.2199
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0456	0.043
Onchocerca volvulus		0.0108	0.1814	0.3705
Trypanosoma brucei	prolyl endopeptidase	0.0175	0.3125	1
Schistosoma mansoni	amine GPCR	0.0038	0.0456	0.0537
Trypanosoma cruzi	oligopeptidase B-like protein, putative	0.0079	0.1267	0.3845
Onchocerca volvulus	Prolyl endopeptidase homolog	0.0175	0.3125	0.728
Echinococcus multilocularis	somatostatin receptor	0.0038	0.0456	0.043
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0456	0.0537
Brugia malayi	prolyl oligopeptidase family protein	0.0087	0.1413	0.1327
Brugia malayi	hypothetical protein	0.0038	0.0456	0.0361
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0038	0.0456	0.043
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0456	0.0356
Trypanosoma cruzi	serine peptidase, clan SC, family S9A-like protein, putative	0.0079	0.1267	0.3845
Trypanosoma brucei	oligopeptidase b	0.0079	0.1267	0.4016
Mycobacterium tuberculosis	Probable protease II PtrBb [second part] (oligopeptidase B)	0.0079	0.1267	0.4894
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0456	0.043
Brugia malayi	prolyl oligopeptidase family protein	0.0033	0.0364	0.0268
Echinococcus granulosus	neuropeptide s receptor	0.0526	0.9984	0.9984
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0456	0.0537
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0038	0.0456	0.0537
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0038	0.0456	0.043

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 5.6 uM	Inhibition of human recombinant PREP expressed in Escherichia coli using Z-Gly-Pro-p-nitroanilide as substrate incubated for 15 mins prior to substrate addition	ChEMBL.	24900696
IC50 (binding)	= 9.4 uM	Inhibition of mouse recombinant FAP expressed in HEK293 cells using Ala-Pro-p-nitroanilide as substrate incubated for 15 mins prior to substrate addition	ChEMBL.	24900696
IC50 (binding)	> 100 uM	Inhibition of DPP2 in human seminal plasma using Lys-Ala-p-nitroanilide as substrate incubated for 15 mins prior to substrate addition	ChEMBL.	24900696
IC50 (binding)	> 100 uM	Inhibition of DPP4 in human seminal plasma using Gly-Pro-p-nitroanilide as substrate incubated for 15 mins prior to substrate addition	ChEMBL.	24900696

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2385285

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1776475