TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 401.446 | Formula: C23H25F2NO3
H donors: 1 H acceptors: 2 LogP: 2.22 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)C1CCCN(C1)CCO/C=C\c1cc(F)ccc1Cc1ccccc1F
InChi: 1S/C23H25F2NO3/c24-21-8-7-17(14-19-4-1-2-6-22(19)25)18(15-21)9-12-29-13-11-26-10-3-5-20(16-26)23(27)28/h1-2,4,6-9,12,15,20H,3,5,10-11,13-14,16H2,(H,27,28)/b12-9-
InChiKey: LFJRBVHGXKJLHK-XFXZXTDPSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	solute carrier family 6 (neurotransmitter transporter, GABA), member 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Sodium- and chloride-dependent GABA transporter 2, putative	Get druggable targets OG5_126944	All targets in OG5_126944
Schistosoma japonicum	ko:K05046 solute carrier family 6 (neurotransmitter transporter, GABA), member, putative	Get druggable targets OG5_126944	All targets in OG5_126944
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	Get druggable targets OG5_126944	All targets in OG5_126944
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126944	All targets in OG5_126944
Schistosoma japonicum	ko:K10420 dynein light chain Tctex-type 1, putative	Get druggable targets OG5_126944	All targets in OG5_126944
Schistosoma japonicum	Sodium- and chloride-dependent creatine transporter 1, putative	Get druggable targets OG5_126944	All targets in OG5_126944
Schistosoma japonicum	IPR000175,Sodium:neurotransmitter symporter,domain-containing	Get druggable targets OG5_126944	All targets in OG5_126944
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	Get druggable targets OG5_126944	All targets in OG5_126944
Schistosoma japonicum	IPR000175,Sodium:neurotransmitter symporter,domain-containing	Get druggable targets OG5_126944	All targets in OG5_126944
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	Get druggable targets OG5_126944	All targets in OG5_126944
Schistosoma japonicum	Sodium- and chloride-dependent GABA transporter 3, putative	Get druggable targets OG5_126944	All targets in OG5_126944
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	Get druggable targets OG5_126944	All targets in OG5_126944
Schistosoma japonicum	IPR000175,Sodium:neurotransmitter symporter,domain-containing	Get druggable targets OG5_126944	All targets in OG5_126944
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	Get druggable targets OG5_126944	All targets in OG5_126944
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126944	All targets in OG5_126944

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	solute carrier family 6 (neurotransmitter transporter, GABA), member 1	599 aa	605 aa	22.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0063	0.0143	0.0672
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0019	0.0035	0.0321
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0019	0.0035	0.0566
Brugia malayi	hypothetical protein	0.0019	0.0035	0.0566
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0287	0.4683
Loa Loa (eye worm)	hypothetical protein	0.0257	0.0612	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0566
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0019	0.0035	0.0566
Echinococcus multilocularis	survival motor neuron protein 1	0.0257	0.0612	0.2882
Onchocerca volvulus		0.0019	0.0035	0.2971
Onchocerca volvulus		0.0019	0.0035	0.2971
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0038	0.0082	0.0082
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0019	0.0035	0.0321
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0019	0.0035	0.0321
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0566
Brugia malayi	Inositol-1	0.0038	0.0082	0.1345
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0013	0.0063
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0019	0.0035	0.0321
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.0009	0.0081
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0037	0.4477
Schistosoma mansoni	ap endonuclease	0.0019	0.0037	0.0341
Echinococcus granulosus	survival motor neuron protein 1	0.0257	0.0612	0.5661
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0019	0.0035	0.0122
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0063	0.0143	0.1321
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0019	0.0035	0.0321
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0037	0.0341
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0037	0.4477
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0009	0.0041
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0123	0.0287	0.2651
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0013	0.0214
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0007	0.0857
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0019	0.0035	0.0163
Echinococcus multilocularis	serotonin transporter	0.0019	0.0035	0.0163
Trichomonas vaginalis	inositol monophosphatase, putative	0.0038	0.0082	1
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0019	0.0035	0.0163
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0019	0.0035	0.0321
Brugia malayi	hypothetical protein	0.0257	0.0612	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0019	0.0035	0.0566
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0566
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0059	0.0132	0.2164
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0007	0.0857
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0882	0.2124	1
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0019	0.0035	0.0122
Plasmodium falciparum	amino acid transporter, putative	0.0019	0.0035	0.0122
Mycobacterium ulcerans	dihydropteroate synthase 2 FolP2	0.0229	0.0544	0.0544
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0037	0.013
Loa Loa (eye worm)	inositol-1	0.0038	0.0082	0.1345
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0019	0.0035	0.0321
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0037	1
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0037	0.4477
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0013	0.0124
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0063	0.0143	0.1321
Schistosoma mansoni	inositol monophosphatase	0.0038	0.0082	0.0761
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0038	0.0082	1
Brugia malayi	CXXC zinc finger family protein	0.0032	0.0066	0.1084
Toxoplasma gondii	histone lysine methyltransferase SET1	0.006	0.0135	0.0474
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0566
Echinococcus granulosus	sodium and chloride dependent glycine	0.0019	0.0035	0.0321
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0013	0.0219
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0019	0.0035	0.0163
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0007	0.0857
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0566
Plasmodium vivax	amine transporter, putative	0.0019	0.0035	0.0122
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0019	0.0035	0.0163
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0063	0.0143	0.2626
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0005	0.0001	0.0006
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0007	0.0857
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0037	0.0602
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0037	0.4477
Schistosoma mansoni	cpg binding protein	0.0032	0.0066	0.0614
Schistosoma mansoni	sodium/chloride dependent transporter	0.0019	0.0035	0.0321
Echinococcus granulosus	serotonin transporter	0.0019	0.0035	0.0321
Onchocerca volvulus		0.0019	0.0035	0.2971
Echinococcus granulosus	sodium and chloride dependent glycine	0.0019	0.0035	0.0321
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0038	0.0082	1
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0032	0.0066	0.1084
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0007	0.0857
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0037	0.4477
Mycobacterium leprae	PROBABLE DIHYDROPTEROATE SYNTHASE 2 FOLP2 (DHPS 2) (Dihydropteroate pyrophosphorylase 2)	0.0229	0.0544	0.0544
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0082	1
Schistosoma mansoni	sodium/chloride dependent transporter	0.0019	0.0035	0.0321
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0007	0.0857
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0123	0.0287	0.2651
Schistosoma mansoni	sodium/chloride dependent transporter	0.0019	0.0035	0.0321
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0007	0.0857
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0037	0.4477
Loa Loa (eye worm)	norepinephrine transporter	0.0019	0.0035	0.0566
Onchocerca volvulus		0.0032	0.0066	0.5687
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0019	0.0035	0.0566
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0037	0.0678
Plasmodium vivax	hypothetical protein, conserved	0.0019	0.0035	0.0122
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0063	0.0143	0.0143
Toxoplasma gondii	hypothetical protein	0.0019	0.0035	0.0122
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0037	0.0037
Toxoplasma gondii	hypothetical protein	0.0019	0.0035	0.0122
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0123	0.0287	0.135
Onchocerca volvulus		0.0052	0.0117	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0566
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0037	0.0602
Echinococcus granulosus	cpg binding protein	0.0033	0.0071	0.0654
Mycobacterium tuberculosis	Dihydropteroate synthase 1 FolP (DHPS 1) (dihydropteroate pyrophosphorylase 1) (dihydropteroate diphosphorylase 1)	0.0229	0.0544	0.0706
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.0009	0.0041
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0007	0.0857
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0038	0.0082	1
Schistosoma mansoni	cpg binding protein	0.0033	0.0071	0.0654
Leishmania major	methionine synthase, putative	0.0229	0.0544	1
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0082	0.1514
Mycobacterium ulcerans	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0.4139	1	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0007	0.0857
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0038	0.0082	0.0289
Mycobacterium leprae	Probable dihydropteroate synthase 1 FolP1 (DHPS 1) (dihydropteroate pyrophosphorylase 1) (dihydropteroate dipyrophosphorylase 1)	0.0229	0.0544	0.0544
Mycobacterium ulcerans	dihydropteroate synthase 1 FolP1	0.0229	0.0544	0.0544
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0019	0.0035	0.0321
Schistosoma mansoni	survival motor neuron protein	0.0052	0.0117	0.1079
Echinococcus multilocularis	cpg binding protein	0.0033	0.0071	0.0333
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0063	0.0143	0.0185
Chlamydia trachomatis	bifunctional 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase/dihydropteroate synthase	0.118	0.2844	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0019	0.0035	0.0566
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0019	0.0035	0.0566
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0019	0.0035	0.0321
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0009	0.0081
Schistosoma mansoni	cpg binding protein	0.0033	0.0071	0.0654
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0037	0.4477
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0038	0.0082	1
Echinococcus multilocularis	inositol monophosphatase 1	0.0038	0.0082	0.0388
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0034	0.0073	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0287	0.4683
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0007	0.0857
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0007	0.0857
Echinococcus granulosus	inositol monophosphatase 1	0.0038	0.0082	0.0761
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0019	0.0035	0.0566
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0019	0.0035	0.0566
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0037	0.013
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0007	0.0857
Mycobacterium leprae	Probable 5-methyltetrahydrofolate--homocystein methyltransferase MetH (Methionine synthase, vitamin-B12 dependent isozyme) (MS)	0.0229	0.0544	0.0544
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0007	0.0857
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0566
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0019	0.0035	0.0321
Schistosoma mansoni	inositol monophosphatase	0.0038	0.0082	0.0761
Onchocerca volvulus		0.0019	0.0035	0.2971
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0123	0.0287	0.2651
Echinococcus multilocularis	dnaJ subfamily B	0.0451	0.1081	0.509
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.0037	1
Mycobacterium tuberculosis	Dihydropteroate synthase 2 FolP2 (DHPS 2) (dihydropteroate pyrophosphorylase 2)	0.0229	0.0544	0.0706
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0007	0.0857
Loa Loa (eye worm)	serotonin transporter b	0.0019	0.0035	0.0566
Toxoplasma gondii	dihydropteroate synthase	0.118	0.2844	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0052	0.0117	0.1906
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0063	0.0143	0.2333
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0034	0.0073	0.0073
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0019	0.0035	0.0122
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0037	0.0174
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0067	0.0152	0.1408
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0007	0.0857
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0082	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0007	0.0857
Schistosoma mansoni	hypothetical protein	0.0052	0.0117	0.1079
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0566
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0063	0.0143	0.0143
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0123	0.0287	0.2651
Plasmodium falciparum	hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase	0.118	0.2844	1
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0082	1
Plasmodium vivax	hydroxymethylpterin pyrophosphokinase-dihydropteroate synthetase, putative	0.118	0.2844	1
Trichomonas vaginalis	helicase, putative	0.0007	0.0007	0.0857
Mycobacterium tuberculosis	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FolK (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase) (	0.3188	0.77	1
Echinococcus granulosus	dnaJ subfamily B	0.0451	0.1081	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0009	0.0081
Plasmodium falciparum	transporter, putative	0.0019	0.0035	0.0122
Toxoplasma gondii	exonuclease III APE	0.0019	0.0037	0.013
Schistosoma mansoni	hypothetical protein	0.0451	0.1081	1
Schistosoma mansoni	ap endonuclease	0.0019	0.0037	0.0341
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0037	0.0048
Mycobacterium ulcerans	B12-dependent methionine synthase	0.0229	0.0544	0.0544
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0007	0.0857

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)	= 71.1 %	Inhibition of mouse GAT2 expressed in HEK cells assessed as remaining [3H]-GABA uptake at 100 uM after 25 mins by liquid scintillation counting analysis relative to control	ChEMBL.	23598250
IC50 (binding)	= 4.55	Inhibition of mouse GAT3 expressed in HEK cells assessed as inhibition of [3H]-GABA uptake after 25 mins by liquid scintillation counting analysis	ChEMBL.	23598250
IC50 (binding)	= 6.52	Inhibition of mouse GAT1 expressed in HEK cells assessed as inhibition of [3H]-GABA uptake after 25 mins by liquid scintillation counting analysis	ChEMBL.	23598250

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2387677

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1778434