Detailed information for compound 177923

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 392.474 | Formula: C21H20N4O2S
  • H donors: 3 H acceptors: 3 LogP: 3.4 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCNS(=O)(=O)c1ccc(cc1)Nc1c2ccccc2nc2c1ccc(c2)N
  • InChi: 1S/C21H20N4O2S/c1-2-23-28(26,27)16-10-8-15(9-11-16)24-21-17-5-3-4-6-19(17)25-20-13-14(22)7-12-18(20)21/h3-13,23H,2,22H2,1H3,(H,24,25)
  • InChiKey: XJZYCJSESUJVLH-UHFFFAOYSA-N  


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Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0337 0.061 0.0604
Trichomonas vaginalis PIKK family atypical protein kinase 0.2821 0.5382 0.538
Trichomonas vaginalis PIKK family atypical protein kinase 0.1752 0.3328 0.3325
Entamoeba histolytica protein kinase, putative 0.0032 0.0024 0.0023
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0988 0.186 0.1841
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0023 0.0006 0.0001
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0337 0.061 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0337 0.061 0.0604
Trichomonas vaginalis PIKK family atypical protein kinase 0.5225 1 1
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0337 0.061 0.0604
Leishmania major phosphatidylinositol 3-kinase, putative 0.0337 0.061 0.0539
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0337 0.061 0.0604
Leishmania major phosphatidylinositol 4-kinase, putative 0.0337 0.061 0.0539
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0988 0.186 0.186
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0059 0.0075 0.0051
Schistosoma mansoni voltage-gated potassium channel 0.0033 0.0026 0.0022
Giardia lamblia Phosphatidylinositol 4-kinase 0.0337 0.061 0.0609
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2471 0.4709 0.4697
Loa Loa (eye worm) phosphatidylinositol 3 0.0337 0.061 0.0604
Trichomonas vaginalis PIKK family atypical protein kinase 0.4156 0.7946 0.7945
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0023 0.0006 0.0006
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.5225 1 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0033 0.0026 0.0026
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.5225 1 1
Brugia malayi p70 ribosomal S6 kinase beta 0.003 0.002 0.0014
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1752 0.3328 0.3312
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0337 0.061 0.0604
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0059 0.0075 0.0075
Trichomonas vaginalis PIKK family atypical protein kinase 0.1752 0.3328 0.3325
Entamoeba histolytica protein kinase, putative 0.003 0.002 0.0019
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0337 0.061 0.0796
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0115 0.0183 0.0177
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0059 0.0075 0.007
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0337 0.061 0.0606
Trichomonas vaginalis PIKK family atypical protein kinase 0.3392 0.6478 0.6476
Plasmodium vivax hypothetical protein 0.0337 0.061 1
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0337 0.061 0.0587
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0023 0.0006 0.0006
Leishmania major phosphatidylinositol 3-kinase, putative 0.1752 0.3328 0.3278
Onchocerca volvulus 0.0337 0.061 0.5
Echinococcus granulosus voltage gated potassium channel 0.0033 0.0026 0.0026
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0337 0.061 0.061
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0059 0.0075 0.5
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1752 0.3328 0.3328
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1752 0.3328 0.3325
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0337 0.061 0.0604
Trichomonas vaginalis PIKK family atypical protein kinase 0.4156 0.7946 0.7945
Trichomonas vaginalis PIKK family atypical protein kinase 0.0337 0.061 0.0604
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0337 0.061 0.0604
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.5225 1 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0115 0.0183 0.0177
Trichomonas vaginalis PIKK family atypical protein kinase 0.3122 0.596 0.5958
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1752 0.3328 0.3328
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0024 0.0018
Schistosoma mansoni immunophilin 0.0059 0.0075 0.007
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0337 0.061 0.0609
Loa Loa (eye worm) phosphatidylinositol 3 0.5225 1 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0337 0.061 0.061
Trypanosoma brucei target of rapamycin kinase 3, putative 0.416 0.7954 0.795
Loa Loa (eye worm) phosphatidylinositol 3 0.0337 0.061 0.0604
Entamoeba histolytica protein kinase, putative 0.0032 0.0024 0.0023
Echinococcus granulosus hyperpolarization activated cyclic 0.0023 0.0006 0.0006
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0115 0.0183 0.0183
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0337 0.061 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0337 0.061 0.0604
Echinococcus multilocularis 0.0337 0.061 0.061
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0059 0.0075 0.0074
Loa Loa (eye worm) AGC/AKT protein kinase 0.0032 0.0024 0.0018
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0337 0.061 0.0609
Echinococcus multilocularis serine protein kinase ATM 0.0988 0.186 0.186
Trichomonas vaginalis PIKK family atypical protein kinase 0.4156 0.7946 0.7945
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0337 0.061 0.061
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0988 0.186 0.186
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0337 0.061 0.0587
Trichomonas vaginalis PIKK family atypical protein kinase 0.3505 0.6695 0.6693
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0337 0.061 0.0604
Trichomonas vaginalis PIKK family atypical protein kinase 0.3886 0.7428 0.7426
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0107 0.0168 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0764 0.143 0.1425
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0337 0.061 0.0796
Giardia lamblia GTOR 0.5225 1 1
Loa Loa (eye worm) FKBP5 protein 0.0059 0.0075 0.0069
Plasmodium vivax hypothetical protein, conserved 0.0337 0.061 1
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0337 0.061 0.0609
Leishmania major hypothetical protein, conserved 0.0337 0.061 0.0539
Entamoeba histolytica hypothetical protein 0.0988 0.186 0.186
Loa Loa (eye worm) hypothetical protein 0.1101 0.2077 0.2073
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0023 0.0006 0.0006
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0337 0.061 0.0609
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0764 0.143 0.143
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.5225 1 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1101 0.2077 0.2777
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0059 0.0075 0.0074
Mycobacterium leprae conserved hypothetical protein 0.0337 0.061 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0337 0.061 0.0604
Schistosoma mansoni immunophilin 0.0059 0.0075 0.007
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0337 0.061 0.0609
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0337 0.061 0.061
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0024 0.0018
Echinococcus multilocularis voltage gated potassium channel 0.0033 0.0026 0.0026
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0337 0.061 0.0587
Trichomonas vaginalis PIKK family atypical protein kinase 0.3886 0.7428 0.7426
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0337 0.061 0.0796
Loa Loa (eye worm) phosphatidylinositol 3 0.0337 0.061 0.0604
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0022 0.0004 0.0004
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0337 0.061 0.0609
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0337 0.061 0.0587
Trichomonas vaginalis PIKK family atypical protein kinase 0.3886 0.7428 0.7426
Trichomonas vaginalis PIKK family atypical protein kinase 0.3886 0.7428 0.7426
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0337 0.061 0.0604
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0024 0.0018
Echinococcus granulosus hyperpolarization activated cyclic 0.0023 0.0006 0.0006
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0059 0.0075 0.5
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0023 0.0006 0.0001
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0051 0.0059 0.0059
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0337 0.061 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0033 0.0026 0.0026
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0337 0.061 0.061
Entamoeba histolytica protein kinase rad3, putative 0.0988 0.186 0.186
Loa Loa (eye worm) hypothetical protein 0.0764 0.143 0.1425
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0059 0.0075 0.0074
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0337 0.061 0.0609
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0337 0.061 0.061
Loa Loa (eye worm) hypothetical protein 0.01 0.0154 0.0148
Trichomonas vaginalis PIKK family atypical protein kinase 0.2821 0.5382 0.538
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0337 0.061 0.0609
Trichomonas vaginalis PIKK family atypical protein kinase 0.4156 0.7946 0.7945
Trichomonas vaginalis PIKK family atypical protein kinase 0.2817 0.5374 0.5371
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0337 0.061 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0988 0.186 0.1856
Trichomonas vaginalis PIKK family atypical protein kinase 0.1752 0.3328 0.3325
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0337 0.061 0.061
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0337 0.061 0.0604
Toxoplasma gondii FATC domain-containing protein 0.0988 0.186 0.2485
Toxoplasma gondii target of rapamycin (TOR), putative 0.3886 0.7428 1
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0337 0.061 0.0609
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0059 0.0075 0.1219
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0337 0.061 0.061
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0059 0.0075 0.0075
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0988 0.186 0.1857
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0764 0.143 0.143
Trichomonas vaginalis PIKK family atypical protein kinase 0.4156 0.7946 0.7945
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0337 0.061 0.0606
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0337 0.061 0.0609
Echinococcus multilocularis Zinc finger, PHD finger 0.0337 0.061 0.061
Trichomonas vaginalis PIKK family atypical protein kinase 0.3886 0.7428 0.7426
Trichomonas vaginalis PIKK family atypical protein kinase 0.2821 0.5382 0.538
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0988 0.186 0.186
Entamoeba histolytica hypothetical protein 0.0337 0.061 0.0609
Schistosoma mansoni hypothetical protein 0.0337 0.061 0.0606
Leishmania major phosphatidylinositol kinase, putative 0.0337 0.061 0.0539
Trichomonas vaginalis PIKK family atypical protein kinase 0.4461 0.8532 0.8531
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0337 0.061 0.0609
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0059 0.0075 0.0074
Loa Loa (eye worm) phosphatidylinositol 3 0.0337 0.061 0.0604
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0337 0.061 0.0796
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.5225 1 1
Loa Loa (eye worm) phosphatidylinositol kinase 0.0337 0.061 0.0604
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1752 0.3328 0.3312
Loa Loa (eye worm) hypothetical protein 0.0337 0.061 0.0604
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0337 0.061 0.0604
Echinococcus multilocularis rac serine:threonine kinase 0.0022 0.0004 0.0004
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0023 0.0006 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0988 0.186 0.1856
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0023 0.0006 0.0006
Schistosoma mansoni voltage-gated potassium channel 0.0126 0.0203 0.0199
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0023 0.0006 0.0001
Mycobacterium tuberculosis Conserved hypothetical protein 0.0337 0.061 0.5
Loa Loa (eye worm) hypothetical protein 0.0051 0.0059 0.0054
Loa Loa (eye worm) hypothetical protein 0.1065 0.2008 0.2003
Entamoeba histolytica hypothetical protein 0.0337 0.061 0.0609
Trichomonas vaginalis PIKK family atypical protein kinase 0.0651 0.1213 0.1208
Echinococcus multilocularis fk506 binding protein 0.0059 0.0075 0.0075
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0023 0.0006 0.0006
Trypanosoma cruzi Protein kinase B 0.0022 0.0004 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.1402 0.2655 0.2651
Trichomonas vaginalis PIKK family atypical protein kinase 0.3091 0.59 0.5898
Brugia malayi FAT domain containing protein 0.0764 0.143 0.1425
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0006 0.0001
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0337 0.061 0.0606
Trichomonas vaginalis PIKK family atypical protein kinase 0.1752 0.3328 0.3325
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0337 0.061 0.061
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0988 0.186 0.186
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.5225 1 1
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0059 0.0075 0.0069
Schistosoma mansoni fkbp-rapamycin associated protein 0.0988 0.186 0.1857
Loa Loa (eye worm) hypothetical protein 0.0033 0.0026 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0988 0.186 0.1856
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0059 0.0075 0.0074
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1752 0.3328 0.3278
Loa Loa (eye worm) phosphatidylinositol 3 0.1752 0.3328 0.3325
Brugia malayi Protein kinase domain containing protein 0.0032 0.0024 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.1101 0.2077 0.2073
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0059 0.0075 0.0069
Schistosoma mansoni immunophilin 0.0051 0.0059 0.0055
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0024 0.0018
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0115 0.0183 0.0183
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0337 0.061 0.0604
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0337 0.061 0.061
Entamoeba histolytica PH domain containing protein kinase, putative 0.0022 0.0004 0.0004
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0337 0.061 0.0609
Schistosoma mansoni hypothetical protein 0.0764 0.143 0.1426
Trichomonas vaginalis PIKK family atypical protein kinase 0.3122 0.596 0.5958
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0337 0.061 1
Trichomonas vaginalis conserved hypothetical protein 0.0651 0.1213 0.1208
Trichomonas vaginalis PIKK family atypical protein kinase 0.2817 0.5374 0.5371
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0337 0.061 0.0609
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0337 0.061 0.0609
Entamoeba histolytica hypothetical protein 0.0337 0.061 0.0609
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0059 0.0075 0.0074
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0337 0.061 0.0604
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0337 0.061 0.0606
Trichomonas vaginalis PIKK family atypical protein kinase 0.3091 0.59 0.5898
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0059 0.0075 0.1219
Trichomonas vaginalis PIKK family atypical protein kinase 0.3886 0.7428 0.7426
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0337 0.061 0.061
Trichomonas vaginalis immunophilin, putative 0.0059 0.0075 0.0069
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.5225 1 1
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0988 0.186 0.186
Giardia lamblia Hypothetical protein 0.0337 0.061 0.0609
Trichomonas vaginalis PIKK family atypical protein kinase 0.2821 0.5382 0.538
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0337 0.061 0.0604
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0051 0.0059 0.0059
Onchocerca volvulus 0.0337 0.061 0.5
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0024 0.0018
Trichomonas vaginalis fk506-binding protein, putative 0.0059 0.0075 0.0069
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0337 0.061 0.061
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0337 0.061 0.061
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0024 0.0018
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0024 0.0018
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0988 0.186 0.1856
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0059 0.0075 0.0051
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.416 0.7954 0.7939
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0337 0.061 0.0609
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0337 0.061 0.0604
Trichomonas vaginalis PIKK family atypical protein kinase 0.3886 0.7428 0.7426
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0023 0.0006 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.5225 1 1
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0337 0.061 1
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0033 0.0026 0.002
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0337 0.061 0.0606
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0337 0.061 0.0604
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0337 0.061 0.0609
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0059 0.0075 0.0069
Trichomonas vaginalis PIKK family atypical protein kinase 0.5225 1 1
Trypanosoma cruzi target of rapamycin kinase 3 0.416 0.7954 0.7954
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0059 0.0075 0.0074
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0059 0.0075 0.0074
Loa Loa (eye worm) hypothetical protein 0.0651 0.1213 0.1208
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0337 0.061 0.0609
Echinococcus granulosus serine protein kinase ATM 0.0988 0.186 0.186
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0337 0.061 0.0604
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.5225 1 1
Leishmania major phosphatidylinositol kinase related protein, putative 0.0337 0.061 0.0539
Loa Loa (eye worm) hypothetical protein 0.0988 0.186 0.1856
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1752 0.3328 0.3328
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0337 0.061 0.0604
Trichomonas vaginalis PIKK family atypical protein kinase 0.3122 0.596 0.5958
Leishmania major hypothetical protein, unknown function 0.0337 0.061 0.0539
Trichomonas vaginalis PIKK family atypical protein kinase 0.2817 0.5374 0.5371
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0059 0.0075 0.0069
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0337 0.061 0.0606
Trichomonas vaginalis PIKK family atypical protein kinase 0.1752 0.3328 0.3325
Entamoeba histolytica PH domain containing protein kinase, putative 0.0022 0.0004 0.0004
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0059 0.0075 0.0075
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.5225 1 1
Loa Loa (eye worm) hypothetical protein 0.0337 0.061 0.0604
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0651 0.1213 0.1212
Echinococcus multilocularis hyperpolarization activated cyclic 0.0023 0.0006 0.0006
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.5225 1 1
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0337 0.061 0.0539
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.003 0.002 0.0014
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0337 0.061 0.0604
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1752 0.3328 0.3325
Trichomonas vaginalis PIKK family atypical protein kinase 0.0337 0.061 0.0604
Schistosoma mansoni voltage-gated potassium channel 0.0033 0.0026 0.0022
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0337 0.061 0.0606
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.217 0.4131 0.4117
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0337 0.061 0.061
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0023 0.0006 0.0006
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.5225 1 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0023 0.0006 0.0006
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0337 0.061 1
Entamoeba histolytica hypothetical protein 0.0337 0.061 0.0609
Trichomonas vaginalis PIKK family atypical protein kinase 0.0988 0.186 0.1856
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0337 0.061 0.0609
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0337 0.061 0.0609
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1752 0.3328 0.3328
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0023 0.0006 0.0006
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0337 0.061 0.0796
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0107 0.0168 0.0163
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0059 0.0075 0.0069
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0337 0.061 0.0604
Schistosoma mansoni voltage-gated potassium channel 0.0126 0.0203 0.0199
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0337 0.061 0.0609
Echinococcus granulosus serine/threonine protein kinase 0.0022 0.0004 0.0004

Activities

Activity type Activity value Assay description Source Reference
Log 1/D50 (functional) = 4.63 Drug concentration in mole/kg/day providing 50% extension of life in intraperitoneally implanted leukemia L1210 mice. ChEMBL. 7069706
Log 1/LD10 (ADMET) = 4.33 Compound concentration in mole/kg/day lethal to 10% of mice ChEMBL. 7069706

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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