Detailed information for compound 177928

Basic information

Technical information
  • TDR Targets ID: 177928
  • Name: 4-(1-pentyl-3,6-dihydro-2H-pyridin-5-yl)-1,3- thiazol-2-amine
  • MW: 251.391 | Formula: C13H21N3S
  • H donors: 1 H acceptors: 1 LogP: 2.64 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCN1CCC=C(C1)c1csc(n1)N
  • InChi: 1S/C13H21N3S/c1-2-3-4-7-16-8-5-6-11(9-16)12-10-17-13(14)15-12/h6,10H,2-5,7-9H2,1H3,(H2,14,15)
  • InChiKey: ZQQLUAMRCWINDM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(1-pentyl-3,6-dihydro-2H-pyridin-5-yl)thiazol-2-amine
  • 4-(1-pentyl-3,6-dihydro-2H-pyridin-5-yl)-2-thiazolamine
  • [4-(1-amyl-3,6-dihydro-2H-pyridin-5-yl)thiazol-2-yl]amine
  • 4-(1-pentyl-5,6-dihydro-2H-pyridin-3-yl)-1,3-thiazol-2-amine
  • 4-(1-pentyl-5,6-dihydro-2H-pyridin-3-yl)thiazol-2-amine
  • 4-(1-pentyl-5,6-dihydro-2H-pyridin-3-yl)-2-thiazolamine
  • [4-(1-amyl-5,6-dihydro-2H-pyridin-3-yl)thiazol-2-yl]amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2531 0.4133 0.412
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0393 0.0612 0.0554
Loa Loa (eye worm) AGC/AKT protein kinase 0.0035 0.0022 0.002
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0393 0.0612 0.0611
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2043 0.333 0.333
Onchocerca volvulus 0.0393 0.0612 0.5
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0032 0.0018 0.0016
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0393 0.0612 0.0802
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.6093 1 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0022 0.0002 0.0002
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0759 0.1215 0.1215
Loa Loa (eye worm) phosphatidylinositol 3 0.0393 0.0612 0.0611
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.6093 1 1
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0059 0.0062 0.0062
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.2043 0.333 0.3316
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0393 0.0612 0.0611
Schistosoma mansoni immunophilin 0.0059 0.0062 0.006
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0022 0.0002 0.0002
Schistosoma mansoni voltage-gated potassium channel 0.0124 0.0169 0.0167
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0393 0.0612 0.0612
Entamoeba histolytica hypothetical protein 0.0393 0.0612 0.0612
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0059 0.0062 0.0061
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0106 0.0139 0.0138
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0393 0.0612 0.0802
Entamoeba histolytica PH domain containing protein kinase, putative 0.0024 0.0004 0.0004
Leishmania major phosphatidylinositol 3-kinase, putative 0.2043 0.333 0.3289
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0393 0.0612 0.0612
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0393 0.0612 1
Entamoeba histolytica protein kinase rad3, putative 0.1152 0.1863 0.1863
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0393 0.0612 0.0612
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0393 0.0612 1
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0022 0.0002 0.0002
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.6093 1 1
Echinococcus granulosus serine/threonine protein kinase 0.0024 0.0004 0.0004
Mycobacterium leprae conserved hypothetical protein 0.0393 0.0612 0.5
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.6093 1 1
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0059 0.0062 0.006
Giardia lamblia Phosphatidylinositol 4-kinase 0.0393 0.0612 0.0612
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0393 0.0612 0.0611
Loa Loa (eye worm) hypothetical protein 0.0393 0.0612 0.0611
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0393 0.0612 0.0592
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0022 0.002
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0022 0.0002 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.6093 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.4532 0.7429 0.7428
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0393 0.0612 0.0612
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0393 0.0612 0.0612
Trypanosoma cruzi target of rapamycin kinase 3 0.4852 0.7955 0.7955
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0059 0.0062 0.0061
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1152 0.1863 0.1863
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0022 0.002
Echinococcus multilocularis voltage gated potassium channel 0.0033 0.0019 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.3285 0.5375 0.5374
Trichomonas vaginalis PIKK family atypical protein kinase 0.3641 0.5961 0.596
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0393 0.0612 0.0611
Loa Loa (eye worm) phosphatidylinositol 3 0.2043 0.333 0.3329
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0393 0.0612 0.0611
Schistosoma mansoni fkbp-rapamycin associated protein 0.1152 0.1863 0.1861
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0393 0.0612 0.0611
Trichomonas vaginalis PIKK family atypical protein kinase 0.0393 0.0612 0.0611
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.6093 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1152 0.1863 0.1861
Trichomonas vaginalis PIKK family atypical protein kinase 0.0759 0.1215 0.1214
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0393 0.0612 0.0592
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0059 0.0062 0.0061
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0059 0.0062 0.0062
Trypanosoma brucei target of rapamycin kinase 3, putative 0.4852 0.7955 0.7951
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0393 0.0612 0.0611
Echinococcus multilocularis Zinc finger, PHD finger 0.0393 0.0612 0.0612
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0113 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.0033 0.0019 0.0017
Loa Loa (eye worm) hypothetical protein 0.0051 0.0048 0.0047
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0059 0.0062 0.0061
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1284 0.208 0.2782
Schistosoma mansoni voltage-gated potassium channel 0.0033 0.0019 0.0017
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.2043 0.333 0.3316
Trichomonas vaginalis PIKK family atypical protein kinase 0.2043 0.333 0.3329
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0059 0.0062 0.004
Entamoeba histolytica hypothetical protein 0.1152 0.1863 0.1863
Entamoeba histolytica protein kinase, putative 0.0035 0.0022 0.0021
Loa Loa (eye worm) hypothetical protein 0.1152 0.1863 0.1861
Trichomonas vaginalis fk506-binding protein, putative 0.0059 0.0062 0.006
Loa Loa (eye worm) phosphatidylinositol 3 0.6093 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1152 0.1863 0.1861
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2043 0.333 0.333
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0393 0.0612 0.0612
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0393 0.0612 0.0592
Echinococcus multilocularis hyperpolarization activated cyclic 0.0022 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0891 0.1432 0.1431
Leishmania major phosphatidylinositol 3-kinase, putative 0.0393 0.0612 0.0554
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0393 0.0612 0.0612
Trichomonas vaginalis immunophilin, putative 0.0059 0.0062 0.006
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0033 0.0019 0.0019
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0051 0.0048 0.0048
Giardia lamblia Hypothetical protein 0.0393 0.0612 0.0612
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0393 0.0612 0.0611
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0393 0.0612 0.0611
Trichomonas vaginalis PIKK family atypical protein kinase 0.329 0.5384 0.5383
Echinococcus granulosus serine protein kinase ATM 0.1152 0.1863 0.1863
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.6093 1 1
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0059 0.0062 0.0061
Toxoplasma gondii target of rapamycin (TOR), putative 0.4532 0.7429 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0393 0.0612 0.0802
Leishmania major phosphatidylinositol 4-kinase, putative 0.0393 0.0612 0.0554
Trichomonas vaginalis PIKK family atypical protein kinase 0.3605 0.5902 0.5901
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0059 0.0062 0.5
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0393 0.0612 0.0611
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0059 0.0062 0.006
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0393 0.0612 0.0611
Entamoeba histolytica hypothetical protein 0.0393 0.0612 0.0612
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0393 0.0612 0.0612
Trichomonas vaginalis PIKK family atypical protein kinase 0.3285 0.5375 0.5374
Loa Loa (eye worm) hypothetical protein 0.0759 0.1215 0.1214
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0393 0.0612 0.0611
Trichomonas vaginalis PIKK family atypical protein kinase 0.3641 0.5961 0.596
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0891 0.1432 0.1432
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0393 0.0612 0.0612
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0393 0.0612 0.0611
Trichomonas vaginalis PIKK family atypical protein kinase 0.2043 0.333 0.3329
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0393 0.0612 0.0611
Trichomonas vaginalis PIKK family atypical protein kinase 0.6093 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0393 0.0612 0.0611
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0393 0.0612 0.0611
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0393 0.0612 0.0612
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0059 0.0062 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.5202 0.8533 0.8532
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0393 0.0612 1
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0393 0.0612 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0393 0.0612 0.0611
Trichomonas vaginalis PIKK family atypical protein kinase 0.1152 0.1863 0.1861
Trichomonas vaginalis PIKK family atypical protein kinase 0.4532 0.7429 0.7428
Echinococcus multilocularis 0.0393 0.0612 0.0612
Trichomonas vaginalis PIKK family atypical protein kinase 0.329 0.5384 0.5383
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0393 0.0612 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.4847 0.7947 0.7946
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0891 0.1432 0.1432
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0393 0.0612 0.0802
Trichomonas vaginalis PIKK family atypical protein kinase 0.3605 0.5902 0.5901
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0022 0.0002 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.1635 0.2657 0.2656
Trypanosoma cruzi Protein kinase B 0.0024 0.0004 0.0004
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0059 0.0062 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0759 0.1215 0.1214
Loa Loa (eye worm) hypothetical protein 0.1242 0.201 0.2008
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0393 0.0612 0.0611
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0051 0.0048 0.0048
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0393 0.0612 0.0611
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0022 0.0002 0.0002
Schistosoma mansoni voltage-gated potassium channel 0.0124 0.0169 0.0167
Echinococcus granulosus hyperpolarization activated cyclic 0.0022 0.0002 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.1152 0.1863 0.1861
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0022 0.0002 0.0002
Loa Loa (eye worm) phosphatidylinositol 3 0.0393 0.0612 0.0611
Entamoeba histolytica hypothetical protein 0.0393 0.0612 0.0612
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0059 0.0062 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0891 0.1432 0.1431
Toxoplasma gondii FATC domain-containing protein 0.1152 0.1863 0.2489
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0393 0.0612 0.0611
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0022 0.002
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0393 0.0612 0.0611
Schistosoma mansoni immunophilin 0.0051 0.0048 0.0047
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0022 0.0002 0.0002
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0059 0.0062 0.006
Entamoeba histolytica PH domain containing protein kinase, putative 0.0024 0.0004 0.0004
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1152 0.1863 0.1861
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0059 0.0062 0.0061
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0393 0.0612 0.0611
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0059 0.0062 0.006
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0393 0.0612 0.0612
Trichomonas vaginalis PIKK family atypical protein kinase 0.4532 0.7429 0.7428
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1152 0.1863 0.1863
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0393 0.0612 0.0612
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0393 0.0612 0.0612
Leishmania major phosphatidylinositol 3-related kinase, putative 0.2043 0.333 0.3289
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1152 0.1863 0.1861
Trichomonas vaginalis PIKK family atypical protein kinase 0.3285 0.5375 0.5374
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0393 0.0612 0.0592
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0393 0.0612 0.0612
Trichomonas vaginalis PIKK family atypical protein kinase 0.329 0.5384 0.5383
Trichomonas vaginalis PIKK family atypical protein kinase 0.4847 0.7947 0.7946
Loa Loa (eye worm) hypothetical protein 0.0098 0.0127 0.0125
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0393 0.0612 0.0612
Schistosoma mansoni hypothetical protein 0.0891 0.1432 0.1431
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0393 0.0612 0.0612
Trichomonas vaginalis conserved hypothetical protein 0.1284 0.208 0.2078
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0024 0.0004 0.0004
Echinococcus multilocularis serine protein kinase ATM 0.1152 0.1863 0.1863
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0393 0.0612 0.0612
Leishmania major hypothetical protein, unknown function 0.0393 0.0612 0.0554
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0393 0.0612 0.0612
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0059 0.0062 0.006
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.6093 1 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0393 0.0612 0.0612
Brugia malayi FAT domain containing protein 0.0891 0.1432 0.1431
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0106 0.0139 0.0138
Trichomonas vaginalis PIKK family atypical protein kinase 0.4087 0.6696 0.6696
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0393 0.0612 0.0612
Trichomonas vaginalis PIKK family atypical protein kinase 0.4532 0.7429 0.7428
Schistosoma mansoni voltage-gated potassium channel 0.0033 0.0019 0.0017
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0393 0.0612 0.0612
Trichomonas vaginalis PIKK family atypical protein kinase 0.4532 0.7429 0.7428
Trichomonas vaginalis PIKK family atypical protein kinase 0.4532 0.7429 0.7428
Leishmania major phosphatidylinositol kinase related protein, putative 0.0393 0.0612 0.0554
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0393 0.0612 0.0612
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0393 0.0612 0.0611
Loa Loa (eye worm) phosphatidylinositol 3 0.0393 0.0612 0.0611
Trichomonas vaginalis PIKK family atypical protein kinase 0.4532 0.7429 0.7428
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0393 0.0612 0.0611
Entamoeba histolytica protein kinase, putative 0.0035 0.0022 0.0021
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0393 0.0612 0.0612
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0393 0.0612 0.0612
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0022 0.002
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0059 0.0062 0.004
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0393 0.0612 0.0612
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0393 0.0612 0.0612
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0059 0.0062 0.1004
Loa Loa (eye worm) hypothetical protein 0.1284 0.208 0.2078
Giardia lamblia GTOR 0.6093 1 1
Onchocerca volvulus 0.0393 0.0612 0.5
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0393 0.0612 0.0612
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.6093 1 1
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0059 0.0062 0.0062
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0033 0.0019 0.0019
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2043 0.333 0.3329
Trichomonas vaginalis PIKK family atypical protein kinase 0.3641 0.5961 0.596
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0113 0.0152 0.0152
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.6093 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0393 0.0612 0.0611
Loa Loa (eye worm) phosphatidylinositol kinase 0.0393 0.0612 0.0611
Trichomonas vaginalis PIKK family atypical protein kinase 0.4847 0.7947 0.7946
Plasmodium vivax hypothetical protein, conserved 0.0393 0.0612 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2043 0.333 0.333
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0393 0.0612 0.0611
Trichomonas vaginalis PIKK family atypical protein kinase 0.2043 0.333 0.3329
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0059 0.0062 0.1004
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0022 0.002
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0393 0.0612 0.0612
Schistosoma mansoni serine/threonine-protein kinase 0.0024 0.0004 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.2043 0.333 0.3329
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0393 0.0612 1
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1152 0.1863 0.1845
Leishmania major hypothetical protein, conserved 0.0393 0.0612 0.0554
Trichomonas vaginalis PIKK family atypical protein kinase 0.4847 0.7947 0.7946
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1152 0.1863 0.1863
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0393 0.0612 0.0612
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0033 0.0019 0.0017
Entamoeba histolytica hypothetical protein 0.0393 0.0612 0.0612
Loa Loa (eye worm) FKBP5 protein 0.0059 0.0062 0.006
Loa Loa (eye worm) phosphatidylinositol 3 0.0393 0.0612 0.0611
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0393 0.0612 0.0611
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0113 0.0152 0.015
Schistosoma mansoni serine/threonine-protein kinase 0.0024 0.0004 0.0002
Brugia malayi Protein kinase domain containing protein 0.0035 0.0022 0.002
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0393 0.0612 0.0612
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.4852 0.7955 0.7942
Echinococcus multilocularis rac serine:threonine kinase 0.0024 0.0004 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.4847 0.7947 0.7946
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0393 0.0612 0.0612
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2882 0.4711 0.4699
Mycobacterium tuberculosis Conserved hypothetical protein 0.0393 0.0612 0.5
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0022 0.002
Echinococcus multilocularis fk506 binding protein 0.0059 0.0062 0.0062
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1152 0.1863 0.1863
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0393 0.0612 1
Leishmania major phosphatidylinositol kinase, putative 0.0393 0.0612 0.0554
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0393 0.0612 0.0611
Schistosoma mansoni hypothetical protein 0.0393 0.0612 0.0611
Trichomonas vaginalis PIKK family atypical protein kinase 0.6093 1 1
Loa Loa (eye worm) hypothetical protein 0.0393 0.0612 0.0611
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0393 0.0612 0.0612
Echinococcus multilocularis hyperpolarization activated cyclic 0.0022 0.0002 0.0002
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1152 0.1863 0.1863
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2043 0.333 0.333
Echinococcus granulosus voltage gated potassium channel 0.0033 0.0019 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.329 0.5384 0.5383
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0393 0.0612 0.0612
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0393 0.0612 0.0612
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0393 0.0612 0.0802
Trichomonas vaginalis PIKK family atypical protein kinase 0.3956 0.6479 0.6479
Plasmodium vivax hypothetical protein 0.0393 0.0612 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0113 0.0152 0.015
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0059 0.0062 0.006
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0393 0.0612 0.0611
Entamoeba histolytica protein kinase, putative 0.0032 0.0018 0.0018
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.2043 0.333 0.3329
Schistosoma mansoni immunophilin 0.0059 0.0062 0.006
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0393 0.0612 0.0611
Trichomonas vaginalis PIKK family atypical protein kinase 0.2043 0.333 0.3329
Brugia malayi p70 ribosomal S6 kinase beta 0.0032 0.0018 0.0016
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.6093 1 1
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0022 0.002
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.6093 1 1

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 4.1 mg kg-1 Inhibition of locomotor activity was determined after interperitoneal administration in mouse ChEMBL. 1967314
ED50 (functional) = 15.6 mg kg-1 Inhibition of locomotor activity was determined after oral administration in rat ChEMBL. 1967314
ED50 (functional) > 30 mg kg-1 Reversal of reserpine-induced depression in rat after subcutaneous administration ChEMBL. 1967314
IC50 (binding) = 1850 nM Inhibition of [3H]-haloperidol binding for Dopamine receptor D2 in rat striatal membranes. ChEMBL. 1967314
IC50 (binding) = 6396 nM Inhibition of [3H]-N-propylnorapomorphine binding to Dopamine receptor D2 of rat striatal membranes ChEMBL. 1967314
Inhibition (functional) = 0 % Decrease of DOPA formation effected by 30 mg/kg administered intraperitoneally in the striatum of GBL-treated rats ChEMBL. 1967314

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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