Detailed information for compound 1783211

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 373.79 | Formula: C18H16ClN3O4
  • H donors: 0 H acceptors: 3 LogP: 3.52 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(/C=C/c2nnc(o2)c2cccnc2Cl)cc(c1OC)OC
  • InChi: 1S/C18H16ClN3O4/c1-23-13-9-11(10-14(24-2)16(13)25-3)6-7-15-21-22-18(26-15)12-5-4-8-20-17(12)19/h4-10H,1-3H3/b7-6+
  • InChiKey: RFSVIGDEXZMDPU-VOTSOKGWSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0209 0.0894
Trypanosoma brucei glucose transporter, putative 0.0032 0.0613 0.2126
Brugia malayi Membrane calcium atpase protein 3 0.0011 0.0125 0.0365
Schistosoma mansoni transmemberane protein 0.0021 0.0347 0.1535
Schistosoma mansoni sugar transporter 0.0015 0.0209 0.0926
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0615 0.0918
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0613 0.269
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0614 0.2153
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0014 0.0188 0.0833
Onchocerca volvulus 0.0015 0.0209 0.0654
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0614 0.2131
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0104 0.2257 0.791
Onchocerca volvulus 0.0015 0.0209 0.0654
Echinococcus granulosus solute carrier family 22 0.0015 0.0209 0.0733
Toxoplasma gondii sugar transporter ST2 0.0015 0.0209 0.0304
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0209 0.061
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0021 0.0347 0.1215
Loa Loa (eye worm) hypothetical protein 0.0007 0.0025 0.0072
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0615 0.0607
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0326 1
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0559 0.1958
Echinococcus multilocularis Immunoglobulin 0.0009 0.0091 0.0318
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.2257 0.791
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0009 0.0091 0.0318
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0009 0.0091 0.0402
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0209 0.0894
Schistosoma mansoni sugar transporter 0.0015 0.0209 0.0926
Echinococcus granulosus calcium transporting atpase 0.0011 0.0125 0.0439
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0707 0.2458
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0209 0.0894
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0406 1
Echinococcus granulosus apoptotic protease activating factor 1 0.0042 0.0834 0.2922
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.0021 0.0347 0.1215
Schistosoma mansoni caspase-7 (C14 family) 0.0042 0.0834 0.3694
Toxoplasma gondii transporter, major facilitator family protein 0.0015 0.0209 0.0304
Schistosoma mansoni glycyl-tRNA synthetase 0.0006 0.0008 0.0036
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0013 0.0161 0.0566
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0014 0.0188 0.2967
Loa Loa (eye worm) calcium ATPase 0.0008 0.0051 0.0148
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0011 0.0125 0.0555
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0406 0.1798
Onchocerca volvulus 0.0015 0.0209 0.0654
Leishmania major glucose transporter, lmgt2 0.0032 0.0613 0.2126
Toxoplasma gondii P-type ATPase4, putative 0.0014 0.0188 0.0272
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0209 0.5052
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0014 0.0188 0.0659
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0615 0.0607
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0614 0.2153
Toxoplasma gondii sugar transporter ST3 0.0015 0.0209 0.0304
Giardia lamblia Potassium-transporting ATPase alpha chain 1 0.0011 0.0125 0.2018
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0209 0.0894
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0006 0.0008 0.0028
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0021 0.0347 0.1215
Onchocerca volvulus 0.0015 0.0209 0.0654
Loa Loa (eye worm) hypothetical protein 0.0009 0.0091 0.0265
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0613 0.269
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0589 0.2609
Mycobacterium ulcerans cation-transporter ATPase I CtpI 0.0009 0.0087 0.1991
Toxoplasma gondii P-type ATPase PMA1 0.0009 0.0074 0.0099
Echinococcus multilocularis nervana 2 0.0021 0.0347 0.1215
Plasmodium vivax CDK-related protein kinase 6, putative 0.0442 1 1
Plasmodium vivax hexose transporter 0.0104 0.2257 0.2251
Onchocerca volvulus 0.0015 0.0209 0.0654
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0011 0.0125 0.0555
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0209 0.0894
Loa Loa (eye worm) hypothetical protein 0.0015 0.0209 0.061
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0009 0.0087 0.0254
Loa Loa (eye worm) hypothetical protein 0.0015 0.0209 0.061
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.013 0.2854 1
Schistosoma mansoni sugar transporter 0.0015 0.0209 0.0926
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0209 0.0894
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0011 0.0125 0.0412
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0707 0.2458
Schistosoma mansoni glucose transport protein 0.0104 0.2257 1
Echinococcus multilocularis solute carrier family 22 0.0015 0.0209 0.0733
Loa Loa (eye worm) hypothetical protein 0.0015 0.0217 0.0632
Onchocerca volvulus 0.0015 0.0209 0.0654
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0014 0.0188 0.2967
Loa Loa (eye worm) hypothetical protein 0.0015 0.0209 0.061
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0209 0.0733
Toxoplasma gondii E1-E2 ATPase subfamily protein 0.0006 0.0011 0.0005
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.013 0.2854 1
Echinococcus granulosus neuroglian 0.0012 0.0146 0.0512
Loa Loa (eye worm) hypothetical protein 0.0014 0.0188 0.0548
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0589 0.2064
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0006 0.0008 0.0023
Leishmania major glucose transporter, lmgt3 0.0032 0.0613 0.2126
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.0011 0.0125 0.0439
Echinococcus granulosus glycyl tRNA synthetase 0.0006 0.0008 0.0028
Onchocerca volvulus 0.0015 0.0209 0.0654
Echinococcus granulosus Immunoglobulin 0.0009 0.0091 0.0318
Giardia lamblia Hexose transporter 0.0015 0.0209 0.346
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0021 0.0347 0.1215
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0406 0.0398
Onchocerca volvulus 0.0015 0.0209 0.0654
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0014 0.0188 0.08
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0014 0.0188 0.0632
Trichomonas vaginalis cation-transporting ATPase, putative 0.0014 0.0188 0.08
Loa Loa (eye worm) hypothetical protein 0.0015 0.0209 0.061
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0011 0.0125 0.0177
Brugia malayi Probable calcium-transporting ATPase KIAA0703 0.0007 0.0025 0.0072
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0406 0.1423
Trypanosoma cruzi P-type H+-ATPase, putative 0.0006 0.0011 0.0011
Onchocerca volvulus 0.0015 0.0209 0.0654
Plasmodium falciparum mitogen-activated protein kinase 2 0.0169 0.3736 0.3731
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0023
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0014 0.0188 0.08
Loa Loa (eye worm) hypothetical protein 0.0015 0.0209 0.061
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0707 0.2458
Chlamydia trachomatis proline--tRNA ligase 0.0011 0.0127 0.2978
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0011 0.0125 0.0365
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0614 0.1792
Brugia malayi major facilitator superfamily protein 0.0015 0.0209 0.061
Echinococcus granulosus twitchin 0.0014 0.0202 0.0709
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0614 0.2722
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0015 0.0209 0.0706
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0209 0.0894
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0614 0.2696
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.0021 0.0347 0.1215
Loa Loa (eye worm) hypothetical protein 0.0015 0.0209 0.061
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.013 0.2854 1
Onchocerca volvulus 0.0015 0.0209 0.0654
Trypanosoma cruzi sugar transporter, putative 0.0015 0.0209 0.0706
Loa Loa (eye worm) hypothetical protein 0.0021 0.0347 0.1011
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0209 0.0894
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0559 0.1958
Echinococcus granulosus nervana 2 0.0021 0.0347 0.1215
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0614 0.2153
Trypanosoma brucei calcium-translocating P-type ATPase 0.0011 0.0125 0.0412
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0169 0.3736 0.5639
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0014 0.0188 0.4522
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0613 0.269
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0104 0.2257 0.791
Brugia malayi hypothetical protein 0.0042 0.0834 0.2431
Trichomonas vaginalis glucose transporter, putative 0.0015 0.0209 0.0894
Brugia malayi Sugar transporter family protein 0.0015 0.0209 0.061
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0014 0.0188 0.08
Brugia malayi P38 map kinase family protein 2 0.013 0.2854 0.832
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0014 0.0188 0.08
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0406 0.6849
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0209 0.0733
Echinococcus granulosus roundabout 2 0.0015 0.0217 0.076
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0009 0.0091 0.0402
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0014 0.0188 0.0632
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0615 0.0918
Brugia malayi Sodium/potassium-transporting ATPase alpha-3 chain, putative 0.0006 0.0011 0.0032
Onchocerca volvulus 0.0015 0.0209 0.0654
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0589 0.1717
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0614 0.2153
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0014 0.0188 0.018
Loa Loa (eye worm) hypothetical protein 0.0009 0.0091 0.0265
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0014 0.0188 0.0632
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.2257 1
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0707 0.1058
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0589 0.1717
Toxoplasma gondii facilitative glucose transporter GT1 0.0104 0.2257 0.3403
Plasmodium vivax sugar transporter, putative 0.0015 0.0209 0.0201
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0209 0.0894
Echinococcus granulosus nervana 2 0.0021 0.0347 0.1215
Echinococcus multilocularis neuroglian 0.0012 0.0146 0.0512
Schistosoma mansoni vesicular amine transporter 0.0009 0.0091 0.0402
Onchocerca volvulus 0.0021 0.0347 0.1084
Leishmania major calcium-transporting ATPase, putative 0.0011 0.0125 0.0412
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0014 0.0188 0.0659
Schistosoma mansoni protein kinase 0.0032 0.0614 0.2722
Schistosoma mansoni glucose transport protein 0.0104 0.2257 1
Echinococcus granulosus solute carrier family 22 0.0015 0.0209 0.0733
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0209 0.0894
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0406 0.1398
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0589 0.2609
Loa Loa (eye worm) hypothetical protein 0.0006 0.0011 0.0032
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0209 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0613 0.269
Brugia malayi Immunoglobulin I-set domain containing protein 0.0009 0.0091 0.0265
Echinococcus multilocularis calcium transporting atpase 0.0011 0.0125 0.0439
Giardia lamblia Sugar-proton symporter 0.0015 0.0209 0.346
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0167 0.0488
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.013 0.2854 0.832
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0209 0.0894
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0014 0.0188 0.2967
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0406 0.1769
Schistosoma mansoni nephrin 0.0012 0.0146 0.0647
Trichomonas vaginalis myo-inositol transporter, putative 0.0015 0.0209 0.0894
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0011 0.0125 0.0555
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0209 0.0733
Plasmodium falciparum calcium-transporting ATPase 0.0011 0.0125 0.0117
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0613 0.2126
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0209 0.061
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0169 0.3736 0.3731
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0613 0.2126
Plasmodium falciparum hexose transporter 0.0104 0.2257 0.2251
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0326 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0209 0.0894
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.2257 0.791
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0021 0.0347 0.1215
Leishmania major myo-inositol/proton symporter (MIT) 0.0015 0.0209 0.0706
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0406 0.1398
Onchocerca volvulus 0.014 0.309 0.9663
Echinococcus granulosus nervana 2 0.0021 0.0347 0.1215
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0007 0.0025 0.0072
Loa Loa (eye worm) sugar transporter 0.0104 0.2257 0.6582
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0008 0.0056 0.0164
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0209 0.0894
Loa Loa (eye worm) hypothetical protein 0.0009 0.0091 0.0265
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0406 0.1798
Loa Loa (eye worm) hypothetical protein 0.0015 0.0209 0.061
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0615 0.0607
Brugia malayi Na,K-ATPase alpha subunit 0.0014 0.0188 0.0548
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0014 0.0188 0.0632
Plasmodium falciparum protein kinase 7 0.0295 0.6618 0.6616
Trypanosoma cruzi hexose transporter, putative 0.0015 0.0209 0.0706
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0014 0.0188 0.0659
Echinococcus granulosus nervana 2 0.0021 0.0347 0.1215
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0209 0.0894
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.0011 0.0125 0.0439
Trypanosoma cruzi plasma-membrane proton-efflux P-type ATPase, putative 0.0006 0.0011 0.0011
Schistosoma mansoni protein kinase 0.0032 0.0614 0.2722
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0014 0.0188 0.0632
Loa Loa (eye worm) hypothetical protein 0.0009 0.0091 0.0265
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0021 0.0347 0.1535
Leishmania major protein kinase, putative 0.0032 0.0614 0.2131
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.0127 1
Schistosoma mansoni glucose transporter 0.0015 0.0209 0.0926
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0008 0.0051 0.0706
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0613 0.2126
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0613 0.2126
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0406 0.6849
Trypanosoma cruzi P-type H+-ATPase, putative 0.0009 0.0074 0.0231
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0015 0.0209 0.0201
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.0009 0.0087 0.1364
Loa Loa (eye worm) hypothetical protein 0.0031 0.0589 0.1717
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0209 0.0894
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0614 0.2153
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0209 0.0894
Echinococcus multilocularis roundabout 2 0.0015 0.0217 0.076
Brugia malayi Fibronectin type III domain containing protein 0.0009 0.0091 0.0265
Plasmodium vivax calcium-transporting ATPase, putative 0.0014 0.0188 0.018
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.0011 0.0125 0.0439
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0613 0.2126
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0589 0.2064
Mycobacterium tuberculosis Possible metal cation transporting P-type ATPase CtpH 0.0009 0.0087 0.2494
Loa Loa (eye worm) hypothetical protein 0.0013 0.0161 0.0471
Onchocerca volvulus 0.0015 0.0209 0.0654
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.0011 0.0125 0.0439
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0209 0.0894
Loa Loa (eye worm) hypothetical protein 0.0009 0.0091 0.0265
Trypanosoma brucei sugar transporter, putative 0.0015 0.0209 0.0706
Entamoeba histolytica protein kinase, putative 0.0032 0.0614 1
Trypanosoma cruzi P-type H+-ATPase, putative 0.0009 0.0074 0.0231
Trypanosoma cruzi glucose transporter, putative 0.0015 0.0209 0.0706
Onchocerca volvulus 0.0014 0.0188 0.0588
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0406 0.1423
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0209 0.0894
Entamoeba histolytica protein kinase, putative 0.0032 0.0614 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0091 0.0265
Loa Loa (eye worm) hypothetical protein 0.0042 0.0834 0.2431
Echinococcus multilocularis nervana 2 0.0021 0.0347 0.1215
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0209 0.0894
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0613 0.269
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0615 0.0607
Echinococcus multilocularis mitogen activated protein kinase 14 0.013 0.2854 1
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0209 0.5052
Loa Loa (eye worm) hypothetical protein 0.0021 0.0347 0.1011
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0209 1
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0011 0.0125 0.0555
Schistosoma mansoni sugar transporter 0.0015 0.0209 0.0926
Trypanosoma cruzi hexose transporter 0.0032 0.0613 0.2126
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0209 0.0894
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0406 0.0602
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0406 0.1398
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0209 0.0894
Leishmania major P-type H -ATPase, putative 0.0009 0.0074 0.0231
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0278 0.0949
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0006 0.0008 0.0023
Trypanosoma brucei glucose transporter, putative 0.0032 0.0613 0.2126
Brugia malayi Cam kinase protein 1 0.0032 0.0614 0.1792
Trichomonas vaginalis sugar transport protein, putative 0.0015 0.0209 0.0894
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0707 0.07
Echinococcus multilocularis General substrate transporter 0.0089 0.1922 0.6736
Trypanosoma brucei glucose transporter, putative 0.0032 0.0613 0.2126
Onchocerca volvulus 0.0015 0.0209 0.0654
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0209 0.0894
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0014 0.0188 0.0632
Loa Loa (eye worm) hypothetical protein 0.0015 0.0209 0.061
Leishmania major calcium motive p-type ATPase, putative 0.0011 0.0125 0.0412
Schistosoma mansoni tyrosine kinase 0.0008 0.0053 0.0233
Loa Loa (eye worm) hypothetical protein 0.0015 0.0217 0.0632
Brugia malayi hypothetical protein 0.0015 0.0209 0.061
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0209 0.0894
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0104 0.2257 0.791
Echinococcus multilocularis solute carrier family 22 0.0015 0.0209 0.0733
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0589 0.9579
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0209 0.0894
Schistosoma mansoni cell adhesion molecule 0.0013 0.0161 0.0715
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0006 0.0008 0.0023
Toxoplasma gondii sugar transporter ST1 0.0015 0.0209 0.0304
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0589 0.2583
Plasmodium vivax P-type ATPase4, putative 0.0014 0.0188 0.018
Echinococcus multilocularis solute carrier family 22 0.0015 0.0209 0.0733
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0021 0.0347 0.1215
Brugia malayi hypothetical protein 0.0015 0.0209 0.061
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0209 0.0894
Loa Loa (eye worm) hypothetical protein 0.0031 0.0589 0.1717
Echinococcus granulosus caspase 2 0.0042 0.0834 0.2922
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0209 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0209 0.0894
Echinococcus multilocularis nervana 2 0.0021 0.0347 0.1215
Loa Loa (eye worm) hypothetical protein 0.0015 0.0209 0.061
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0707 0.2458
Trypanosoma cruzi calcium-transporting ATPase, putative 0.0007 0.0025 0.0058
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0015 0.0209 0.6328
Onchocerca volvulus 0.0015 0.0209 0.0654
Echinococcus granulosus solute carrier family 22 0.0015 0.0209 0.0733
Echinococcus multilocularis glycyl tRNA synthetase 0.0006 0.0008 0.0028
Brugia malayi Sugar transporter family protein 0.0015 0.0209 0.061
Trypanosoma brucei P-type H+-ATPase, putative 0.0009 0.0074 0.0231
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0014 0.0188 0.08
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0104 0.2257 0.791
Echinococcus multilocularis apoptotic protease activating factor 1 0.0042 0.0834 0.2922
Trypanosoma brucei glucose transporter 2A 0.0032 0.0613 0.2126
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0209 0.0894
Onchocerca volvulus 0.0042 0.0834 0.2608
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0326 0.5469
Onchocerca volvulus Cell death protein 3 homolog 0.0042 0.0834 0.2608
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0209 0.0894
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0006 0.0008 0.0023
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0589 1
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0406 0.0398
Loa Loa (eye worm) sugar transporter 0.0015 0.0209 0.061
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0615 0.0607
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0014 0.0188 0.0659
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0021 0.0347 0.1535
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0021 0.0347 0.1215
Echinococcus granulosus Threonyl tRNA synthetase C 0.0006 0.0008 0.0028
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0209 0.0894
Trypanosoma brucei glucose transporter, putative 0.0032 0.0613 0.2126
Leishmania major glucose transporter, lmgt1 0.0032 0.0613 0.2126
Loa Loa (eye worm) hypothetical protein 0.0015 0.0209 0.061
Echinococcus multilocularis Immunoglobulin 0.0009 0.0091 0.0318
Echinococcus granulosus Na:K ATPase alpha subunit 0.0011 0.0125 0.0439
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0209 0.0733
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0014 0.0188 0.4522
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0011 0.0125 0.2018
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0021 0.0347 0.1535
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0209 0.0894
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.013 0.2854 1
Brugia malayi major facilitator superfamily protein 0.0015 0.0209 0.061
Echinococcus granulosus solute carrier family 22 0.0015 0.0209 0.0733
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0014 0.0188 0.0272
Echinococcus multilocularis mitogen activated protein kinase 11 0.013 0.2854 1
Brugia malayi Cell death protein 3 precursor 0.0042 0.0834 0.2431
Onchocerca volvulus 0.0021 0.0347 0.1084
Trypanosoma brucei glucose transporter, putative 0.0032 0.0613 0.2126
Leishmania major hypothetical protein, conserved 0.0015 0.0209 0.0706
Schistosoma mansoni ATPase 0.0014 0.0188 0.0833
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0615 0.0607
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0014 0.0188 0.0659
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0155 0.343 1
Echinococcus multilocularis caspase 2 0.0042 0.0834 0.2922
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0209 0.0894
Loa Loa (eye worm) hypothetical protein 0.0015 0.0209 0.061
Echinococcus multilocularis nervana 2 0.0021 0.0347 0.1215
Loa Loa (eye worm) E1-E2 ATPase 0.0009 0.0074 0.0215
Brugia malayi hypothetical protein 0.0015 0.0209 0.061
Schistosoma mansoni protein kinase 0.0032 0.0614 0.2722
Schistosoma mansoni glucose transport protein 0.0104 0.2257 1
Trypanosoma brucei glucose transporter, putative 0.0032 0.0613 0.2126
Loa Loa (eye worm) sodium potassium adenosine triphosphatase 0.0006 0.0011 0.0032
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0615 0.0607
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0613 0.2126
Entamoeba histolytica plasma membrane calcium-transporting ATPase 1, putative 0.0008 0.0051 0.0706
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0209 0.0894
Trypanosoma brucei calcium motive p-type ATPase, putative 0.0011 0.0125 0.0412
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0614 0.2153
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0613 0.269
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0614 0.2153
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0011 0.0125 0.0555
Trypanosoma brucei glucose transporter 1E 0.0032 0.0613 0.2126
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0014 0.0188 0.0632
Trichomonas vaginalis cation-transporting ATPase, putative 0.0014 0.0188 0.08
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.2257 0.791
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0615 0.0607
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0074 0.0292
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0014 0.0188 0.0272
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0615 0.0607
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0011 0.0125 0.0412
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0209 0.061
Onchocerca volvulus 0.0015 0.0209 0.0654
Loa Loa (eye worm) hypothetical protein 0.0014 0.0188 0.0548
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.2257 0.791
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0209 0.5052
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0021 0.0347 0.1535
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0008 0.0051 0.0148
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0014 0.0188 0.2967
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0406 1
Schistosoma mansoni ATPase 0.0014 0.0188 0.0833
Echinococcus multilocularis solute carrier family 22 0.0015 0.0209 0.0733
Brugia malayi hypothetical protein 0.0009 0.0091 0.0265
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.034 0.1477
Loa Loa (eye worm) hypothetical protein 0.0015 0.0209 0.061
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0209 0.061
Loa Loa (eye worm) hypothetical protein 0.0025 0.0455 0.1326
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0006 0.0011 0.0011
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0014 0.0188 0.08
Brugia malayi Sugar transporter family protein 0.0104 0.2257 0.6582
Mycobacterium ulcerans sugar transporter 0.0015 0.0209 0.5052
Schistosoma mansoni na+/k+ atpase alpha subunit 0.0011 0.0125 0.0555
Echinococcus granulosus mitogen activated protein kinase 11 0.013 0.2854 1
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0613 0.269
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0614 0.1792
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0014 0.0188 0.3097
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0014 0.0188 0.0659
Onchocerca volvulus Putative transporter 0.0015 0.0209 0.0654
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0209 0.0894
Trypanosoma brucei P-type H+-ATPase, putative 0.0009 0.0074 0.0231
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0707 0.2458
Loa Loa (eye worm) hypothetical protein 0.0042 0.0834 0.2431
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0014 0.0188 0.0632
Brugia malayi calcium ATPase 0.0006 0.0011 0.0032
Toxoplasma gondii protein kinase, putative 0.0295 0.6618 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0155 0.343 1
Brugia malayi glycyl-tRNA synthetase 0.0006 0.0008 0.0023
Schistosoma mansoni hypothetical protein 0.0042 0.0834 0.3694
Leishmania major calcium-translocating P-type ATPase 0.0014 0.0188 0.0632
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0209 0.061
Trichomonas vaginalis cation-transporting ATPase, putative 0.0014 0.0188 0.08
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0006 0.0011 0.005
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0015 0.0209 0.6328
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0209 0.0894
Onchocerca volvulus 0.0015 0.0209 0.0654
Schistosoma mansoni hypothetical protein 0.0104 0.2257 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0614 0.1792
Echinococcus granulosus General substrate transporter 0.0089 0.1922 0.6736
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0209 0.0894
Onchocerca volvulus Tyrosine kinase homolog 0.0145 0.3197 1
Echinococcus multilocularis mitogen activated protein kinase 11 0.013 0.2854 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0209 0.0894
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0406 1
Brugia malayi E1-E2 ATPase family protein 0.0009 0.0074 0.0215
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0615 0.0918
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0209 0.0926
Trypanosoma brucei glucose transporter, putative 0.0032 0.0613 0.2126
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0406 0.1184
Loa Loa (eye worm) hypothetical protein 0.0015 0.0209 0.061
Loa Loa (eye worm) hypothetical protein 0.0015 0.0209 0.061
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0614 0.1792
Echinococcus granulosus mitogen activated protein kinase 14 0.013 0.2854 1
Trypanosoma brucei glucose transporter, putative 0.0032 0.0613 0.2126
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0014 0.0188 0.0548
Leishmania major P-type H -ATPase, putative 0.0009 0.0074 0.0231
Trypanosoma brucei calcium-transporting ATPase, putative 0.0007 0.0025 0.0058
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0614 0.2153
Echinococcus granulosus defective proboscis extension response 0.0009 0.0091 0.0318
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0707 0.07
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0011 0.0125 0.0521
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0011 0.0127 0.2978
Loa Loa (eye worm) hypothetical protein 0.0023 0.0406 0.1184
Leishmania major P-type ATPase, putative 0.0011 0.0125 0.0412
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0209 0.0894
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0009 0.0087 0.0254
Entamoeba histolytica hypothetical protein 0.0023 0.0406 0.6561
Echinococcus multilocularis mitogen activated protein kinase 14 0.013 0.2854 1
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0589 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0209 0.0894
Loa Loa (eye worm) hypothetical protein 0.0015 0.0209 0.061
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0613 0.2126
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.0011 0.0125 0.0439

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 61.21 uM Inhibition of electric eel AChE using acetylthiocholine as substrate incubated for 20 mins prior to substrate addition measured every 30 secs for 4 mins by Ellman's method ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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