Detailed information for compound 1790283

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 335.363 | Formula: C17H17N7O
  • H donors: 2 H acceptors: 4 LogP: 1.22 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCCNc1ccn2c(n1)c(cn2)c1cccc(c1)c1nnc(o1)C
  • InChi: 1S/C17H17N7O/c1-11-22-23-17(25-11)13-4-2-3-12(9-13)14-10-20-24-8-5-15(19-7-6-18)21-16(14)24/h2-5,8-10H,6-7,18H2,1H3,(H,19,21)
  • InChiKey: XYDAVXLWFUQNSH-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens casein kinase 2, beta polypeptide Starlite/ChEMBL References
Homo sapiens Pim-1 proto-oncogene, serine/threonine kinase Starlite/ChEMBL References
Homo sapiens checkpoint kinase 1 Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 3 Starlite/ChEMBL References
Homo sapiens casein kinase 2, alpha prime polypeptide References
Homo sapiens Pim-2 proto-oncogene, serine/threonine kinase Starlite/ChEMBL References
Homo sapiens casein kinase 2, alpha 1 polypeptide References
Homo sapiens mechanistic target of rapamycin (serine/threonine kinase) Starlite/ChEMBL References
Homo sapiens Pim-3 proto-oncogene, serine/threonine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans Casein kinase II, regulatory (beta-prime) subunit Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma mansoni protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni casein kinase II beta subunit Get druggable targets OG5_126846 All targets in OG5_126846
Candida albicans frameshifted from upsteam TOR2 CDS (CaP19.9461) Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely protein kinase similar to S. cerevisiae CKA1 (YIL035C) alpha subunit of protein kinase 2, aka casein kinase II Get druggable targets OG5_126901 All targets in OG5_126901
Theileria parva casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Candida albicans Casein kinase II alpha' subunit Get druggable targets OG5_126901 All targets in OG5_126901
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Plasmodium berghei casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania infantum casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Trypanosoma cruzi Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Toxoplasma gondii ck2 beta subunit Get druggable targets OG5_126846 All targets in OG5_126846
Neospora caninum casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K07203 FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana protein kinase ck2 regulatory subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma japonicum Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei phosphatidylinositol 4-kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Serine/threonine-protein kinase Pim-3 Get druggable targets OG5_134863 All targets in OG5_134863
Leishmania major target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) CAMK/PIM protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Serine/threonine-protein kinase Chk1, putative Get druggable targets OG5_130454 All targets in OG5_130454
Theileria parva casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei casein kinase 2, alpha subunit Get druggable targets OG5_126901 All targets in OG5_126901
Schistosoma japonicum ko:K03115 casein kinase 2, beta polypeptide, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma congolense casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Plasmodium yoelii Protein kinase domain Get druggable targets OG5_126901 All targets in OG5_126901
Cryptosporidium parvum putative protein kinase CK2 regulatory subunit CK2B1 Get druggable targets OG5_126846 All targets in OG5_126846
Onchocerca volvulus Casein kinase II subunit beta homolog Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma brucei gambiense protein kinase ck2 regulatory subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei Casein kinase II Get druggable targets OG5_126901 All targets in OG5_126901
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_134863 All targets in OG5_134863
Trypanosoma brucei gambiense casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Plasmodium knowlesi casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii casein kinase ii beta chain Get druggable targets OG5_126846 All targets in OG5_126846
Echinococcus multilocularis FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Toxoplasma gondii casein kinase ii regulatory subunit protein Get druggable targets OG5_126846 All targets in OG5_126846
Babesia bovis casein kinase II beta 4 subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma japonicum ko:K04702 proto-oncogene serine/threonine-protein kinase Pim-1, putative Get druggable targets OG5_134863 All targets in OG5_134863
Echinococcus granulosus casein kinase ii subunit alpha Get druggable targets OG5_126901 All targets in OG5_126901
Cryptosporidium hominis protein kinase domain Get druggable targets OG5_126901 All targets in OG5_126901
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Theileria parva casein kinase II, alpha chain Get druggable targets OG5_126901 All targets in OG5_126901
Brugia malayi Csnk2b protein Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma japonicum ko:K03115 casein kinase 2, beta polypeptide, putative Get druggable targets OG5_126846 All targets in OG5_126846
Neospora caninum YOR039Wp-like protein, related Get druggable targets OG5_126846 All targets in OG5_126846
Candida albicans Casein kinase II, regulatory (beta-prime) subunit Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania braziliensis protein kinase ck2 regulatory subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Onchocerca volvulus Casein kinase II subunit beta homolog Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum Phosphatidylinositol 3-kinase tor2, related Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase Get druggable targets OG5_130454 All targets in OG5_130454
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica casein kinase II regulatory subunit family protein Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium yoelii protein kinase Ck2-beta Get druggable targets OG5_126846 All targets in OG5_126846
Cryptosporidium parvum casein kinase II, alpha subunit, putative Get druggable targets OG5_126901 All targets in OG5_126901
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Babesia bovis protein kinase CK2 regulatory subunit CK2B1 Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma japonicum ko:K03097 casein kinase 2, alpha polypeptide, putative Get druggable targets OG5_126901 All targets in OG5_126901
Giardia lamblia Kinase, CMGC CK2 Get druggable targets OG5_126901 All targets in OG5_126901
Candida albicans frameshifted from upstream TOR2 CDS (CaP19.1905) Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Leishmania infantum protein kinase ck2 regulatory subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma brucei gambiense phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_130454 All targets in OG5_130454
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium falciparum casein kinase II beta chain Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis protein kinase Ck2-beta Get druggable targets OG5_126846 All targets in OG5_126846
Giardia lamblia GTOR Get druggable targets OG5_127212 All targets in OG5_127212
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Plasmodium vivax casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Toxoplasma gondii CMGC kinase, CK2 family Get druggable targets OG5_126901 All targets in OG5_126901
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) CMGC/CK2 protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Giardia lamblia Casein kinase II beta chain Get druggable targets OG5_126846 All targets in OG5_126846
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum putative casein kinase II regulatory subunit; besthit Pf 23508244 Get druggable targets OG5_126846 All targets in OG5_126846
Brugia malayi Casein kinase II, alpha chain Get druggable targets OG5_126901 All targets in OG5_126901
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica casein kinase II regulatory subunit family protein Get druggable targets OG5_126846 All targets in OG5_126846
Echinococcus multilocularis casein kinase ii subunit beta Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Onchocerca volvulus Serine\/threonine protein kinase homolog Get druggable targets OG5_134863 All targets in OG5_134863
Leishmania mexicana phosphatidylinositol 3-kinase (tor2)-like protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium vivax unspecified product Get druggable targets OG5_126901 All targets in OG5_126901
Plasmodium falciparum casein kinase 2, alpha subunit Get druggable targets OG5_126901 All targets in OG5_126901
Entamoeba histolytica casein kinase II regulatory subunit family protein Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Leishmania major protein kinase ck2 regulatory subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_130454 All targets in OG5_130454
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans Casein kinase II, regulatory (beta) subunit Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma congolense Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum casein kinase II beta chain Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania donovani Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus casein kinase ii subunit beta Get druggable targets OG5_126846 All targets in OG5_126846
Loa Loa (eye worm) CAMK/PIM protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Leishmania donovani Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma congolense Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis proto oncogene serine:threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Babesia bovis casein kinase II, alpha chain (CK II) Get druggable targets OG5_126901 All targets in OG5_126901
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax casein kinase 2, alpha subunit, putative Get druggable targets OG5_126901 All targets in OG5_126901
Candida albicans Casein kinase II alpha' subunit Get druggable targets OG5_126901 All targets in OG5_126901
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus proto oncogene serine:threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Plasmodium knowlesi casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania donovani Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania infantum target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Toxoplasma gondii target of rapamycin (TOR), putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi casein kinase 2, alpha subunit, putative Get druggable targets OG5_126901 All targets in OG5_126901
Plasmodium berghei casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium vivax casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Loa Loa (eye worm) Csnk2b protein Get druggable targets OG5_126846 All targets in OG5_126846
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis casein kinase ii subunit alpha Get druggable targets OG5_126901 All targets in OG5_126901
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum hypothetical protein Get druggable targets OG5_126901 All targets in OG5_126901
Candida albicans Casein kinase II, regulatory (beta) subunit Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126901 All targets in OG5_126901
Entamoeba histolytica casein kinase, putative Get druggable targets OG5_126901 All targets in OG5_126901
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Trypanosoma brucei protein lipid droplet kinase (LDK) Pim-2 proto-oncogene, serine/threonine kinase 311 aa 278 aa 28.8 %
Trypanosoma brucei protein lipid droplet kinase (LDK) Pim-3 proto-oncogene, serine/threonine kinase 326 aa 296 aa 29.7 %
Trypanosoma cruzi casein kinase II, alpha chain, putative casein kinase 2, alpha 1 polypeptide 391 aa 316 aa 51.3 %
Trypanosoma cruzi casein kinase II, alpha chain, putative casein kinase 2, alpha prime polypeptide 350 aa 319 aa 50.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0052 0.0585 0.0628
Brugia malayi PXA domain containing protein 0.0052 0.0585 0.016
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0052 0.0585 0.016
Echinococcus granulosus expressed protein 0.0052 0.0585 0.0179
Echinococcus multilocularis Regulator of G protein signaling 20 0.0052 0.0585 0.0179
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0432 0.1092
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0054 0.0632 0.0821
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0044 0.0432 0.1508
Brugia malayi Protein kinase domain containing protein 0.0057 0.0681 0.0259
Echinococcus multilocularis regulator of G protein signaling 3 0.0052 0.0585 0.0179
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0432 0.1092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0135 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0355 0.0809
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0355 0.0809
Loa Loa (eye worm) hypothetical protein 0.0052 0.0585 0.016
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0432 0.1092
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0052 0.0585 0.0179
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0411 0.1014
Schistosoma mansoni serine/threonine protein kinase 0.0207 0.367 0.3384
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0276 0.0521
Echinococcus granulosus cyclin dependent kinase 0.0057 0.0681 0.0291
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0681 0.0259
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0389 0.7304 0.7182
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0052 0.0585 0.016
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0585 0.1651
Echinococcus granulosus beta-adrenergic receptor kinase 0.0057 0.0688 0.0299
Giardia lamblia GTOR 0.0054 0.0632 0.0821
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0472 0.8965 1
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0681 0.0259
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0054 0.0632 0.0897
Loa Loa (eye worm) hypothetical protein 0.0052 0.0578 0.0152
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0632 0.1823
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0191 0.0208
Loa Loa (eye worm) hypothetical protein 0.0052 0.0585 0.016
Giardia lamblia Kinase, CMGC CDK 0.0057 0.0681 0.1019
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0432 0.1092
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0054 0.0632 0.0897
Brugia malayi PXA domain containing protein 0.0052 0.0585 0.016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0411 0.1014
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0044 0.0432 0.0307
Schistosoma mansoni serine/threonine protein kinase 0.0389 0.7304 0.7182
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0389 0.7304 0.7182
Echinococcus granulosus cyclin dependent kinase 5 0.0057 0.0681 0.0291
Plasmodium falciparum casein kinase 2, alpha subunit 0.0166 0.2868 1
Echinococcus granulosus axis inhibition protein axin 0.0052 0.0585 0.0179
Echinococcus multilocularis beta adrenergic receptor kinase 0.0057 0.0688 0.0299
Plasmodium falciparum protein kinase 5 0.0057 0.0681 0.1019
Echinococcus multilocularis cyclin dependent kinase 1 0.0057 0.0681 0.0291
Leishmania major casein kinase II, putative 0.0166 0.2868 1
Echinococcus multilocularis cyclin dependent kinase 5 0.0057 0.0681 0.0291
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0688 0.0267
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0585 0.1651
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0135 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0355 0.0809
Echinococcus multilocularis regulator of G protein signaling 0.0052 0.0585 0.0179
Entamoeba histolytica cell division protein kinase 2, putative 0.0057 0.0681 0.1019
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0524 1 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0054 0.0632 0.0209
Echinococcus granulosus regulator of G protein signaling 3 0.0052 0.0585 0.0179
Brugia malayi Casein kinase II, alpha chain 0.0166 0.2868 0.2546
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0585 0.1651
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0432 0.1092
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0585 0.1651
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0197 0.0231
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0585 0.1651
Trichomonas vaginalis CMGC family protein kinase 0.0166 0.2868 1
Trypanosoma cruzi cdc2-related kinase 3 0.0057 0.0681 0.1094
Brugia malayi A-kinase anchor protein 10, precursor 0.0052 0.0585 0.016
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0044 0.0432 0.0083
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0044 0.0432 0.0083
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0052 0.0585 0.016
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0632 0.0209
Loa Loa (eye worm) PXA domain-containing protein 0.0052 0.0585 0.016
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0054 0.0632 0.0897
Toxoplasma gondii ck2 beta subunit 0.0044 0.0432 0.0307
Echinococcus granulosus Regulator of G protein signaling 20 0.0052 0.0585 0.0179
Echinococcus multilocularis cyclin dependent kinase 1 0.0057 0.0681 0.0291
Echinococcus multilocularis axis inhibition protein axin 0.0052 0.0585 0.0179
Trypanosoma cruzi cdc2-related kinase 1 0.0057 0.0681 0.1094
Trichomonas vaginalis CMGC family protein kinase 0.0166 0.2868 1
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0389 0.7304 0.8053
Brugia malayi regulator of G-protein signaling rgs-7 0.0052 0.0585 0.016
Echinococcus granulosus cyclin dependent kinase 1 0.0057 0.0681 0.0291
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0057 0.0681 0.0259
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0057 0.0681 0.0291
Entamoeba histolytica casein kinase, putative 0.0166 0.2868 1
Trichomonas vaginalis CMGC family protein kinase 0.0166 0.2868 1
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0472 0.8965 1
Trypanosoma brucei cdc2-related kinase 3 0.0057 0.0681 0.2373
Brugia malayi Regulator of G protein signaling domain containing protein 0.0052 0.0585 0.016
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0389 0.7304 0.8053
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0054 0.0632 0.0234
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0432 0.1092
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0432 0.1092
Trichomonas vaginalis CMGC family protein kinase 0.0166 0.2868 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0054 0.0632 0.2205
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0472 0.8965 0.8919
Loa Loa (eye worm) hypothetical protein 0.0052 0.0585 0.016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0411 0.1014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0191 0.0208
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0054 0.0632 0.0234
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0688 0.0267
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0474 0.1245
Brugia malayi Protein kinase domain containing protein 0.0389 0.7304 0.7182
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0411 0.1014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0632 0.1823
Entamoeba histolytica hypothetical protein 0.0052 0.0585 0.0628
Trichomonas vaginalis CMGC family protein kinase 0.0166 0.2868 1
Trypanosoma cruzi casein kinase II, putative 0.0166 0.2868 1
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0166 0.2868 0.2546
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0052 0.0585 0.1651
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0057 0.0681 0.1094
Echinococcus granulosus regulator of G protein signaling 7 0.0052 0.0585 0.0179
Brugia malayi hypothetical protein 0.0052 0.0585 0.016
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0432 0.1092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0197 0.0231
Echinococcus multilocularis axis inhibition protein axin 0.0052 0.0585 0.0179
Toxoplasma gondii CMGC kinase, CK2 family 0.0166 0.2868 1
Trypanosoma cruzi cdc2-related kinase 1 0.0057 0.0681 0.1094
Echinococcus multilocularis regulator of G protein signaling 3 0.0052 0.0585 0.0179
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0197 0.0231
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0166 0.2868 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0052 0.0585 0.0179
Loa Loa (eye worm) hypothetical protein 0.0052 0.0585 0.016
Echinococcus granulosus axis inhibition protein axin 0.0052 0.0585 0.0179
Echinococcus multilocularis casein kinase ii subunit alpha 0.0166 0.2868 0.2854
Giardia lamblia Kinase, CMGC CK2 0.0166 0.2868 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0585 0.016
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0052 0.0585 0.016
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0026 0.0062 0.0217
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0057 0.0681 0.0259
Schistosoma mansoni regulator of G protein signaling 0.0052 0.0585 0.016
Echinococcus multilocularis regulator of G protein signaling 7 0.0052 0.0585 0.0179
Schistosoma mansoni z-protein (S1r protein) 0.0052 0.0585 0.016
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0052 0.0585 0.0179
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0057 0.0681 0.1295
Schistosoma mansoni regulator of G protein signaling 0.0052 0.0585 0.016
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0389 0.7304 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0253 0.0435
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0355 0.0809
Echinococcus granulosus regulator of G protein signaling 3 0.0052 0.0585 0.0179
Echinococcus granulosus regulator of G protein signaling 7 0.0052 0.0585 0.0179
Entamoeba histolytica cell division protein kinase 2, putative 0.0057 0.0681 0.1019
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0044 0.0432 0.0083
Schistosoma mansoni serine/threonine protein kinase 0.0524 1 1
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0472 0.8965 0.8919
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0681 0.2
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0472 0.8965 0.8919
Schistosoma mansoni axis inhibition protein axin 0.0052 0.0585 0.016
Trichomonas vaginalis CMGC family protein kinase 0.0166 0.2868 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0355 0.0809
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0135 0.0003
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0043 0.0412 0.1436
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0057 0.0681 0.1094
Schistosoma mansoni regulator of G protein signaling 0.0052 0.0585 0.016
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0355 0.0809
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0432 0.1092
Schistosoma mansoni regulator of G protein signaling 0.0052 0.0585 0.016
Loa Loa (eye worm) RGS-3 protein 0.0052 0.0585 0.016
Schistosoma mansoni protein kinase 0.0166 0.2868 0.2546
Entamoeba histolytica protein kinase domain containing protein 0.0166 0.2868 1
Entamoeba histolytica hypothetical protein 0.0052 0.0585 0.0628
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0054 0.0632 0.0821
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0632 0.0209
Schistosoma mansoni axis inhibition protein axin 0.0052 0.0585 0.016
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0057 0.0688 0.0267
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0389 0.7304 0.7182
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0207 0.367 0.3384
Giardia lamblia Kinase, CMGC CDK 0.0057 0.0681 0.1019
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0054 0.0632 0.2205
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0135 0.0003
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0681 0.2
Loa Loa (eye worm) hypothetical protein 0.0052 0.0585 0.016
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0432 0.1092
Trichomonas vaginalis CMGC family protein kinase 0.0166 0.2868 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0052 0.0585 0.016
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0432 0.1092
Echinococcus multilocularis cyclin dependent kinase 0.0057 0.0681 0.0291
Plasmodium vivax unspecified product 0.0166 0.2868 1
Plasmodium vivax protein kinase Crk2 0.0057 0.0681 0.1019
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0057 0.0681 0.0259
Brugia malayi regulator of G-protein signaling egl-10 0.0052 0.0585 0.016
Echinococcus granulosus casein kinase ii subunit alpha 0.0166 0.2868 0.2854
Trypanosoma brucei cdc2-related kinase 1 0.0057 0.0681 0.2373
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0681 0.2
Brugia malayi cell division control protein 2 homolog 0.0057 0.0681 0.0259
Trypanosoma brucei Casein kinase II 0.0166 0.2868 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0432 0.1092
Schistosoma mansoni regulator of G protein signaling 0.0052 0.0585 0.016
Brugia malayi hypothetical protein 0.0052 0.0585 0.016
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0355 0.0809
Trypanosoma cruzi cdc2-related kinase 3 0.0057 0.0681 0.1094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0632 0.1823
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0585 0.1651
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0054 0.0632 0.0897
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0432 0.1092
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0432 0.1092
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.0432 0.1092
Brugia malayi Protein kinase domain containing protein 0.0207 0.367 0.3384
Echinococcus multilocularis expressed protein 0.0052 0.0585 0.0179
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0411 0.1014

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.3 nM Inhibition of Pim1 (unknown origin) using STK3 as substrate preincubated for 30 mins followed by substrate and ATP addition after 45 mins by HTRF assay ChEMBL. 24091081
IC50 (binding) = 1.8 nM Inhibition of Pim3 (unknown origin) using STK1 as substrate preincubated for 30 mins followed by substrate and ATP addition after 60 mins by HTRF assay ChEMBL. 24091081
IC50 (binding) = 7.3 nM Inhibition of Pim2 (unknown origin) using STK1 as substrate preincubated for 30 mins followed by substrate and ATP addition after 60 mins by HTRF assay ChEMBL. 24091081
IC50 (binding) = 580 nM Inhibition of CDK2 (unknown origin) ChEMBL. 24091081
IC50 (binding) = 950 nM Inhibition of CK2 (unknown origin) ChEMBL. 24091081
IC50 (binding) > 3000 nM Inhibition of mTOR (unknown origin) ChEMBL. 24091081
IC50 (binding) = 7100 nM Inhibition of CHK1 (unknown origin) ChEMBL. 24091081
Inhibition (ADMET) Inhibition of CYP2C9 (unknown origin) at >20 uM ChEMBL. 24091081
Inhibition (ADMET) Inhibition of CYP3A4 (unknown origin) at >20 uM ChEMBL. 24091081
Inhibition (ADMET) Inhibition of CYP2D6 (unknown origin) at >20 uM ChEMBL. 24091081
Inhibition (binding) = 11 % Inhibition of human ERG (unknown origin) at 10 uM ChEMBL. 24091081

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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