Detailed information for compound 180224

Basic information

Technical information
  • TDR Targets ID: 180224
  • Name: ethyl 1-(2-oxo-3-phenylpropanoyl)piperidine-2 -carboxylate
  • MW: 303.353 | Formula: C17H21NO4
  • H donors: 0 H acceptors: 3 LogP: 2.37 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C1CCCCN1C(=O)C(=O)Cc1ccccc1
  • InChi: 1S/C17H21NO4/c1-2-22-17(21)14-10-6-7-11-18(14)16(20)15(19)12-13-8-4-3-5-9-13/h3-5,8-9,14H,2,6-7,10-12H2,1H3
  • InChiKey: KDJAKBJRDJBEOI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 1-(2-oxo-3-phenyl-propanoyl)piperidine-2-carboxylate
  • 1-(1,2-dioxo-3-phenylpropyl)-2-piperidinecarboxylic acid ethyl ester
  • 1-(2-keto-3-phenyl-propanoyl)pipecolin ethyl ester
  • 1-(2-keto-3-phenyl-propanoyl)pipecolinic acid ethyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0944 0.0944
Onchocerca volvulus 0.002 0.0527 0.0612
Trichomonas vaginalis sugar transport protein, putative 0.0007 0.0105 0.0102
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0507 0.0671
Trichomonas vaginalis sugar transporter, putative 0.0007 0.0105 0.0102
Schistosoma mansoni neuropeptide receptor 0.0005 0.0016 0.0016
Onchocerca volvulus 0.0007 0.0105 0.0106
Trypanosoma brucei glucose transporter, putative 0.0016 0.0402 0.4607
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0266 0.0295
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0051 0.161 0.1596
Trichomonas vaginalis sugar transporter, putative 0.0007 0.0105 0.0102
Entamoeba histolytica hypothetical protein 0.0011 0.0249 0.0479
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0033 0.0993 0.0978
Plasmodium vivax CDK-related protein kinase 6, putative 0.0217 0.729 1
Echinococcus multilocularis dnaJ subfamily B 0.0296 1 1
Trichomonas vaginalis sugar transporter, putative 0.0007 0.0105 0.0102
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0033 0.0993 0.0993
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0944 0.093
Echinococcus multilocularis synaptic vesicle 2 protein 0.0007 0.0105 0.0089
Trypanosoma brucei glucose transporter, putative 0.0016 0.0402 0.4607
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0007 0.0109 0.0128
Schistosoma mansoni hypothetical protein 0.0005 0.0016 0.0016
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0007 0.0109 0.0109
Entamoeba histolytica hypothetical protein 0.0026 0.0751 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0016 0.0395 0.0379
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0019 0.0507 0.9969
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0006 0.0075 0.0075
Echinococcus granulosus serine protein kinase ATM 0.0026 0.0749 0.0734
Schistosoma mansoni adenoreceptor 0.0005 0.0016 0.0016
Trichomonas vaginalis CAMK family protein kinase 0.0016 0.0395 0.0449
Entamoeba histolytica hypothetical protein 0.0026 0.0751 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0016 0.0395 0.0379
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0016 0.0395 0.0404
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0019 0.0507 0.537
Brugia malayi hypothetical protein 0.0007 0.0105 0.0121
Schistosoma mansoni amine GPCR 0.0005 0.0016 0.0016
Trichomonas vaginalis sugar transporter, putative 0.0007 0.0105 0.0102
Schistosoma mansoni neuropeptide receptor 0.0005 0.0016 0.0016
Brugia malayi Major Facilitator Superfamily protein 0.0007 0.0105 0.0121
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0019 0.0507 0.0492
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0007 0.0109 0.0128
Loa Loa (eye worm) hypothetical protein 0.0007 0.0109 0.0128
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0507 0.0584
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0019 0.0507 0.6241
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0033 0.0993 0.1335
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0007 0.0109 0.0112
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.001 0.019 1
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0008 0.0141 0.0126
Trypanosoma brucei THT1 - hexose transporter, putative 0.0016 0.0402 0.4607
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0011 0.0249 0.3046
Echinococcus multilocularis calcium dependent protein kinase 0.0015 0.0362 0.0346
Brugia malayi F/Y-rich N-terminus family protein 0.0007 0.0115 0.0136
Loa Loa (eye worm) hypothetical protein 0.0015 0.0384 0.0503
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0006 0.0075 0.0059
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0033 0.0993 0.1335
Plasmodium falciparum protein kinase 6 0.0217 0.729 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0105 0.0121
Echinococcus granulosus solute carrier family 22 0.0007 0.0105 0.0089
Loa Loa (eye worm) hypothetical protein 0.0007 0.0109 0.0128
Schistosoma mansoni lamin 0.002 0.0527 0.0527
Schistosoma mansoni intermediate filament proteins 0.002 0.0527 0.0527
Onchocerca volvulus Bile acid receptor homolog 0.0007 0.0109 0.0112
Schistosoma mansoni hypothetical protein 0.0008 0.0141 0.0141
Brugia malayi Major Facilitator Superfamily protein 0.0007 0.0105 0.0121
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0105 0.0102
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0507 0.0584
Loa Loa (eye worm) sugar transporter 0.0051 0.161 0.2178
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0944 0.093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0507 0.0584
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0007 0.0109 0.0094
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0007 0.0109 0.0128
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0016 0.0395 0.0379
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0051 0.161 0.1596
Schistosoma mansoni cpg binding protein 0.0022 0.0611 0.0611
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0007 0.0109 0.0094
Toxoplasma gondii facilitative glucose transporter GT1 0.0051 0.161 0.3201
Toxoplasma gondii FATC domain-containing protein 0.0026 0.0749 0.137
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0007 0.0105 0.2954
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0016 0.0395 0.0379
Loa Loa (eye worm) hypothetical protein 0.0015 0.0384 0.0503
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0007 0.0109 0.0094
Trypanosoma cruzi hexose transporter 0.0016 0.0402 0.4607
Echinococcus granulosus General substrate transporter 0.0044 0.1363 0.135
Echinococcus multilocularis serine protein kinase ATM 0.0026 0.0749 0.0734
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0507 0.0584
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0507 0.0584
Loa Loa (eye worm) hypothetical protein 0.0007 0.0105 0.0121
Trichomonas vaginalis sugar transporter, putative 0.0007 0.0105 0.0102
Brugia malayi FAT domain containing protein 0.0008 0.0141 0.0171
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0005 0.0016 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0507 0.0584
Plasmodium vivax hexose transporter 0.0051 0.161 0.2094
Chlamydia trachomatis lysine--tRNA ligase 0.0011 0.0249 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0007 0.0109 0.0094
Brugia malayi Cam kinase protein 1 0.0016 0.0395 0.0518
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0007 0.0109 0.0128
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0018 0.0471 0.0779
Brugia malayi Pre-SET motif family protein 0.0032 0.0944 0.1268
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0033 0.0993 0.0993
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0015 0.0384 0.0503
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0005 0.0016 0.0016
Schistosoma mansoni neuropeptide receptor 0.0005 0.0016 0.0016
Plasmodium falciparum proline--tRNA ligase 0.0018 0.0471 0.051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0224 0.0245
Trichomonas vaginalis sugar transporter, putative 0.0007 0.0105 0.0102
Loa Loa (eye worm) hypothetical protein 0.0012 0.0285 0.0368
Trypanosoma cruzi target of rapamycin kinase 3 0.0019 0.0507 0.6241
Echinococcus multilocularis solute carrier family 22 0.0007 0.0105 0.0089
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0507 0.6241
Entamoeba histolytica hypothetical protein 0.0026 0.0751 1
Plasmodium vivax calcium-dependent protein kinase, putative 0.0016 0.0395 0.0404
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0105 0.0102
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0033 0.0993 0.0978
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0051 0.161 0.1596
Onchocerca volvulus 0.0007 0.0105 0.0106
Echinococcus granulosus synaptic vesicle 2 protein 0.0007 0.0105 0.0089
Brugia malayi Steroid receptor seven-up type 2 0.0007 0.0109 0.0128
Echinococcus multilocularis lamin 0.002 0.0527 0.0512
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0007 0.0109 0.0128
Schistosoma mansoni lysyl-tRNA synthetase 0.0011 0.0249 0.0249
Schistosoma mansoni hypothetical protein 0.0005 0.0016 0.0016
Plasmodium vivax proline--tRNA ligase, putative 0.0018 0.0471 0.051
Schistosoma mansoni neuropeptide F-like receptor 0.0005 0.0016 0.0016
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0007 0.0105 0.0089
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0015 0.0384 1
Leishmania major protein kinase, putative 0.0016 0.0395 0.7189
Loa Loa (eye worm) histone methyltransferase 0.0008 0.0118 0.014
Brugia malayi nuclear hormone receptor 0.0007 0.0109 0.0128
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0118 0.0102
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0015 0.0384 0.0436
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0019 0.0507 0.6241
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0944 0.093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0266 0.0295
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0019 0.0507 0.9969
Echinococcus multilocularis FTZ F1 alpha 0.0007 0.0109 0.0094
Echinococcus granulosus lamin dm0 0.002 0.0527 0.0512
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0011 0.0249 1
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0402 0.0457
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.0016 0.0016
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0006 0.0075 0.0059
Trypanosoma cruzi hexose transporter, putative 0.0016 0.0402 0.4607
Schistosoma mansoni protein kinase 0.0016 0.0395 0.0395
Trichomonas vaginalis myo-inositol transporter, putative 0.0007 0.0105 0.0102
Echinococcus granulosus FTZ F1 alpha 0.0007 0.0109 0.0094
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0007 0.0109 0.0094
Loa Loa (eye worm) hypothetical protein 0.0009 0.0169 0.0209
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0507 0.0671
Trichomonas vaginalis sugar transporter, putative 0.0007 0.0105 0.0102
Onchocerca volvulus Huntingtin homolog 0.0089 0.2896 0.345
Schistosoma mansoni hypothetical protein 0.0026 0.0751 0.0751
Loa Loa (eye worm) hypothetical protein 0.0007 0.0105 0.0121
Leishmania major glucose transporter/membrane transporter D2, putative 0.0016 0.0402 0.7359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0507 0.0584
Plasmodium falciparum mitogen-activated protein kinase 2 0.0083 0.2688 0.3595
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0007 0.0109 0.0109
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0507 0.0584
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0105 0.0102
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0019 0.0507 0.6241
Trypanosoma brucei glucose transporter 1E 0.0016 0.0402 0.4607
Schistosoma mansoni opsin-like receptor 0.0005 0.0016 0.0016
Toxoplasma gondii target of rapamycin (TOR), putative 0.0019 0.0507 0.0855
Mycobacterium ulcerans integral membrane transport protein 0.0007 0.0105 0.2954
Schistosoma mansoni amine GPCR 0.0005 0.0016 0.0016
Brugia malayi Sugar transporter family protein 0.0051 0.161 0.2178
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0011 0.0224 0.0209
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0051 0.161 0.1596
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0749 0.0874
Trichomonas vaginalis set domain proteins, putative 0.0248 0.8365 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0007 0.0109 0.0128
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0015 0.0384 0.0384
Trypanosoma brucei glucose transporter, putative 0.0016 0.0402 0.4607
Treponema pallidum prolyl-tRNA synthetase 0.0005 0.0044 0.5
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0051 0.161 0.1596
Schistosoma mansoni amine GPCR 0.0005 0.0016 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0007 0.0109 0.0128
Schistosoma mansoni growth hormone secretagogue receptor 0.0005 0.0016 0.0016
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0007 0.0109 0.0094
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0018 0.0471 0.9078
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0011 0.0249 0.0275
Loa Loa (eye worm) sugar transporter 0.0007 0.0105 0.0121
Trichomonas vaginalis sugar transporter, putative 0.0007 0.0105 0.0102
Schistosoma mansoni biogenic amine (5HT) receptor 0.0005 0.0016 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0105 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.161 0.1905
Schistosoma mansoni cpg binding protein 0.0022 0.0611 0.0611
Loa Loa (eye worm) hypothetical protein 0.0007 0.0105 0.0121
Plasmodium falciparum calcium-dependent protein kinase 4 0.0016 0.0395 0.0404
Trichomonas vaginalis sugar transporter, putative 0.0007 0.0105 0.0102
Trichomonas vaginalis sugar transporter, putative 0.0007 0.0105 0.0102
Trichomonas vaginalis sugar transporter, putative 0.0007 0.0105 0.0102
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0507 0.0584
Loa Loa (eye worm) hypothetical protein 0.0089 0.2896 0.3935
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0224 0.0245
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0011 0.0224 0.0285
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0005 0.0016 0.0016
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0019 0.0507 0.537
Trichomonas vaginalis sugar transporter, putative 0.0007 0.0105 0.0102
Plasmodium falciparum hexose transporter 0.0051 0.161 0.2094
Onchocerca volvulus 0.0007 0.0105 0.0106
Onchocerca volvulus 0.0007 0.0105 0.0106
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0019 0.0507 0.0507
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0005 0.0016 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0224 0.0245
Onchocerca volvulus 0.0021 0.0571 0.0664
Loa Loa (eye worm) hypothetical protein 0.0007 0.0109 0.0128
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.0016 0.0016
Plasmodium falciparum calcium-dependent protein kinase 2 0.0016 0.0395 0.0404
Trichomonas vaginalis sugar transporter, putative 0.0007 0.0105 0.0102
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0944 0.0944
Echinococcus multilocularis solute carrier family 22 0.0007 0.0105 0.0089
Echinococcus granulosus Sugar transporter ERD6 protein 0.0007 0.0105 0.0089
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0016 0.0395 0.0518
Trichomonas vaginalis glucose transporter, putative 0.0016 0.0402 0.0457
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0016 0.0395 0.4501
Schistosoma mansoni hypothetical protein 0.0051 0.161 0.161
Trichomonas vaginalis sugar transporter, putative 0.0007 0.0105 0.0102
Onchocerca volvulus 0.0007 0.0105 0.0106
Trichomonas vaginalis sugar transporter, putative 0.0007 0.0105 0.0102
Loa Loa (eye worm) intermediate filament protein 0.002 0.0527 0.0699
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.0016 0.0016
Loa Loa (eye worm) steroid hormone receptor 0.0007 0.0109 0.0128
Schistosoma mansoni hypothetical protein 0.0123 0.406 0.406
Giardia lamblia Lysyl-tRNA synthetase 0.0011 0.0249 0.3597
Plasmodium falciparum calcium-dependent protein kinase 3 0.0016 0.0395 0.0404
Echinococcus multilocularis solute carrier family 22 0.0007 0.0105 0.0089
Trichomonas vaginalis sugar transporter, putative 0.0007 0.0105 0.0102
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0016 0.0395 0.0617
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.7335 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0005 0.0016 0.0016
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0007 0.0109 0.0109
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0099 0.0095
Loa Loa (eye worm) hypothetical protein 0.0007 0.0109 0.0128
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0507 0.6241
Trypanosoma brucei THT1 - hexose transporter, putative 0.0016 0.0402 0.4607
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0007 0.0109 0.0094
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.0016 0.0016
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0019 0.0508 0.6261
Loa Loa (eye worm) hypothetical protein 0.0008 0.0141 0.0171
Loa Loa (eye worm) hypothetical protein 0.0009 0.0169 0.0209
Schistosoma mansoni transcription factor LCR-F1 0.0026 0.0751 0.0751
Schistosoma mansoni cpg binding protein 0.0021 0.0571 0.0571
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0007 0.0105 0.2954
Loa Loa (eye worm) hypothetical protein 0.0032 0.0944 0.1268
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0015 0.0384 0.0384
Schistosoma mansoni steroid hormone receptor ad4bp 0.0007 0.0109 0.0109
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0507 0.0584
Echinococcus granulosus cpg binding protein 0.0022 0.0611 0.0596
Schistosoma mansoni sugar transporter 0.0007 0.0105 0.0105
Echinococcus granulosus solute carrier family 22 0.0007 0.0105 0.0089
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0051 0.161 0.1596
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0019 0.0507 0.0492
Entamoeba histolytica hypothetical protein 0.0026 0.0749 0.997
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0007 0.0109 0.0128
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0015 0.0384 0.0369
Plasmodium falciparum lysine--tRNA ligase 0.0011 0.0249 0.0201
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0051 0.161 0.1596
Loa Loa (eye worm) CXXC zinc finger family protein 0.0021 0.0571 0.0758
Trypanosoma brucei glucose transporter, putative 0.0016 0.0402 0.4607
Trichomonas vaginalis sugar transporter, putative 0.0007 0.0105 0.0102
Trypanosoma cruzi hexose transporter, putative 0.0016 0.0402 0.4607
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0507 0.0584
Loa Loa (eye worm) major facilitator superfamily transporter 0.0007 0.0105 0.0121
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0007 0.0109 0.0128
Trichomonas vaginalis sugar transporter, putative 0.0007 0.0105 0.0102
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.001 0.019 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0033 0.0993 0.0993
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0944 0.0944
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0005 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0011 0.0249 0.0319
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0507 0.0584
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0007 0.0109 0.0128
Brugia malayi major facilitator superfamily protein 0.0007 0.0105 0.0121
Schistosoma mansoni opsin-like receptor 0.0005 0.0016 0.0016
Schistosoma mansoni coup transcription factor 0.0007 0.0109 0.0109
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0005 0.0016 0.0016
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0016 0.0395 0.0518
Loa Loa (eye worm) hypothetical protein 0.0007 0.0105 0.0121
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.001 0.0217 0.0274
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0507 0.0584
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0624 0.8064
Loa Loa (eye worm) hypothetical protein 0.0007 0.0105 0.0121
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0005 0.0016 0.0016
Echinococcus multilocularis geminin 0.0123 0.406 0.405
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0007 0.0109 0.0109
Echinococcus granulosus calcium dependent protein kinase 0.0015 0.0362 0.0346
Schistosoma mansoni glucose transport protein 0.0051 0.161 0.161
Onchocerca volvulus 0.0007 0.0105 0.0106
Trichomonas vaginalis sugar transporter, putative 0.0007 0.0105 0.0102
Leishmania major lysyl-tRNA synthetase, putative 0.0011 0.0249 0.3586
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0016 0.0395 0.0404
Echinococcus granulosus ecdysone induced protein 78C 0.0007 0.0109 0.0094
Trypanosoma brucei glucose transporter, putative 0.0016 0.0402 0.4607
Brugia malayi nuclear receptor NHR-88 0.0007 0.0109 0.0128
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0011 0.0224 0.1854
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0083 0.2688 0.5495
Toxoplasma gondii protein kinase, putative 0.0144 0.4806 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0141 0.0145
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0889 0.0875
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0045 0.1408 0.1408
Trichomonas vaginalis sugar transporter, putative 0.0007 0.0105 0.0102
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0118 0.0102
Trichomonas vaginalis sugar transporter, putative 0.0007 0.0105 0.0102
Trichomonas vaginalis sugar transporter, putative 0.0007 0.0105 0.0102
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0007 0.0109 0.0094
Brugia malayi Major Facilitator Superfamily protein 0.0007 0.0105 0.0121
Trypanosoma brucei glucose transporter, putative 0.0016 0.0402 0.4607
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.0016 0.0016
Loa Loa (eye worm) major facilitator superfamily transporter 0.0007 0.0105 0.0121
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0026 0.0749 0.0749
Echinococcus granulosus geminin 0.0123 0.406 0.405
Schistosoma mansoni protein kinase 0.0016 0.0395 0.0395
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0507 0.0584
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0011 0.0224 0.0209
Schistosoma mansoni sugar transporter 0.0007 0.0105 0.0105
Leishmania major phosphatidylinositol 3-kinase, putative 0.0019 0.0507 0.9969
Loa Loa (eye worm) hypothetical protein 0.0007 0.0109 0.0128
Brugia malayi hypothetical protein 0.0089 0.2896 0.3935
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0507 0.0584
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0015 0.0384 0.0369
Onchocerca volvulus 0.0007 0.0105 0.0106
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0007 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0007 0.0105 0.0121
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0944 0.0944
Schistosoma mansoni biogenic amine receptor 0.0005 0.0016 0.0016
Schistosoma mansoni biogenic amine receptor 0.0005 0.0016 0.0016
Echinococcus multilocularis lamin dm0 0.002 0.0527 0.0512
Onchocerca volvulus Huntingtin homolog 0.0089 0.2896 0.345
Echinococcus granulosus lysyl tRNA synthetase 0.0011 0.0249 0.0234
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0083 0.2688 0.3595
Trichomonas vaginalis sugar transporter, putative 0.0007 0.0105 0.0102
Loa Loa (eye worm) hypothetical protein 0.0007 0.0105 0.0121
Loa Loa (eye worm) hypothetical protein 0.0007 0.0105 0.0121
Onchocerca volvulus 0.002 0.0527 0.0612
Schistosoma mansoni neuropeptide f receptor 76f 0.0005 0.0016 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0507 0.0584
Toxoplasma gondii lysine-tRNA ligase 0.0011 0.0249 0.0308
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0007 0.0109 0.0094
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0018 0.0471 0.9078
Loa Loa (eye worm) hypothetical protein 0.0012 0.0266 0.0342
Echinococcus granulosus lamin 0.002 0.0527 0.0512
Schistosoma mansoni neuropeptide receptor 0.0005 0.0016 0.0016
Brugia malayi intermediate filament protein 0.002 0.0527 0.0699
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.0016 0.0016
Schistosoma mansoni lamin 0.002 0.0527 0.0527
Brugia malayi hypothetical protein 0.0026 0.0751 0.1004
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0005 0.0016 0.0016
Trichomonas vaginalis glucose transporter, putative 0.0007 0.0105 0.0102
Entamoeba histolytica protein kinase, putative 0.0016 0.0395 0.324
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0402 0.0457
Echinococcus multilocularis thyroid hormone receptor alpha 0.0007 0.0109 0.0094
Loa Loa (eye worm) hypothetical protein 0.0011 0.0224 0.0285
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0007 0.0109 0.0128
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0005 0.0016 0.0016
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0007 0.0109 0.0094
Brugia malayi CXXC zinc finger family protein 0.0021 0.0571 0.0758
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0007 0.0109 0.0128
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0007 0.0109 0.0109
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0224 0.0245
Trichomonas vaginalis sugar transporter, putative 0.0007 0.0105 0.0102
Brugia malayi Nuclear hormone receptor-like 1 0.0007 0.0109 0.0128
Loa Loa (eye worm) hypothetical protein 0.0007 0.0109 0.0128
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.0016 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0402 0.0457
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0507 0.0584
Plasmodium vivax SET domain protein, putative 0.0032 0.0944 0.1168
Trypanosoma brucei glucose transporter 2A 0.0016 0.0402 0.4607
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0011 0.0249 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0011 0.0249 0.0249
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0007 0.0109 0.0128
Echinococcus multilocularis lysyl tRNA synthetase 0.0011 0.0249 0.0234
Trichomonas vaginalis glucose transporter, putative 0.0016 0.0402 0.0457
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0007 0.0109 0.0094
Schistosoma mansoni thyroid hormone receptor 0.0007 0.0109 0.0109
Trichomonas vaginalis PIKK family atypical protein kinase 0.0007 0.0099 0.0095
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0011 0.0249 0.2245
Loa Loa (eye worm) hypothetical protein 0.0009 0.0181 0.0226
Loa Loa (eye worm) hypothetical protein 0.0016 0.0395 0.0518
Schistosoma mansoni biogenic amine (5HT) receptor 0.0005 0.0016 0.0016
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0012 0.0266 0.2502
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0507 0.0584
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0015 0.0384 0.3034
Trichomonas vaginalis sugar transporter, putative 0.0007 0.0105 0.0102
Trichomonas vaginalis sugar transporter, putative 0.0007 0.0105 0.0102
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0019 0.0507 0.6241
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0507 0.0584
Plasmodium falciparum calcium-dependent protein kinase 1 0.0016 0.0395 0.0404
Trypanosoma cruzi hexose transporter, putative 0.0016 0.0402 0.4607
Onchocerca volvulus 0.0032 0.0944 0.1112
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0008 0.0141 0.0126
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0507 0.0584
Echinococcus multilocularis General substrate transporter 0.0044 0.1363 0.135
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0005 0.0016 0.0016
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0006 0.0074 0.008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0507 0.0584
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0507 0.0584
Loa Loa (eye worm) hypothetical protein 0.0007 0.0105 0.0121
Echinococcus granulosus intermediate filament protein 0.002 0.0527 0.0512
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0007 0.0105 0.5
Brugia malayi photoreceptor-specific nuclear receptor 0.0007 0.0109 0.0128
Loa Loa (eye worm) hypothetical protein 0.0019 0.0515 0.0682
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0507 0.0584
Onchocerca volvulus Protein ultraspiracle homolog 0.0007 0.0109 0.0112
Brugia malayi Sugar transporter family protein 0.0007 0.0105 0.0121
Onchocerca volvulus Putative transporter 0.0007 0.0105 0.0106
Loa Loa (eye worm) hypothetical protein 0.002 0.0527 0.0699
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0507 0.0584
Toxoplasma gondii histone lysine methyltransferase SET1 0.0041 0.1247 0.243
Schistosoma mansoni glucose transporter 0.0007 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0007 0.0109 0.0128
Schistosoma mansoni thyroid hormone receptor 0.0007 0.0109 0.0109
Echinococcus granulosus solute carrier family 22 0.0007 0.0105 0.0089
Schistosoma mansoni amine GPCR 0.0005 0.0016 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0007 0.0109 0.0128
Onchocerca volvulus 0.0007 0.0105 0.0106
Echinococcus granulosus mixed lineage leukemia protein mll 0.0006 0.0075 0.0059
Schistosoma mansoni sugar transporter 0.0007 0.0105 0.0105
Brugia malayi major facilitator superfamily protein 0.0007 0.0105 0.0121
Trypanosoma brucei glucose transporter, putative 0.0016 0.0402 0.4607
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0019 0.0507 0.0492
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0507 0.0671
Schistosoma mansoni protein kinase 0.0016 0.0395 0.0395
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.002 0.0527 0.0699
Trypanosoma cruzi hexose transporter, putative 0.0009 0.0155 0.0786
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.0016 0.0016
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0005 0.0016 0.0016
Schistosoma mansoni opsin-like receptor 0.0005 0.0016 0.0016
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0016 0.0395 0.0617
Echinococcus multilocularis cpg binding protein 0.0022 0.0611 0.0596
Schistosoma mansoni biogenic amine receptor 0.0005 0.0016 0.0016
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0009 0.0181 0.0166
Schistosoma mansoni nuclear hormone receptor 0.0007 0.0109 0.0109
Schistosoma mansoni histamine h1 receptor 0.0005 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0007 0.0105 0.0121
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0007 0.0109 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0402 0.0457
Onchocerca volvulus 0.0007 0.0105 0.0106
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0009 0.0181 0.0166
Onchocerca volvulus 0.0007 0.0105 0.0106
Trypanosoma brucei THT1 - hexose transporter, putative 0.0016 0.0402 0.4607
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0507 0.0584
Plasmodium falciparum protein kinase 7 0.0144 0.4806 0.6542
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0019 0.0507 0.6241
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0016 0.0395 0.0379
Brugia malayi Pre-SET motif family protein 0.0218 0.7335 1
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.001 0.0201 0.0217
Brugia malayi Intermediate filament tail domain containing protein 0.002 0.0527 0.0699
Trichomonas vaginalis sugar transporter, putative 0.0007 0.0105 0.0102
Echinococcus multilocularis solute carrier family 22 0.0007 0.0105 0.0089
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0026 0.0751 0.0736
Loa Loa (eye worm) hypothetical protein 0.0007 0.0105 0.0121
Trichomonas vaginalis sugar transporter, putative 0.0007 0.0105 0.0102
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0507 0.0584
Schistosoma mansoni amine GPCR 0.0005 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0005 0.0016 0.0016
Brugia malayi hypothetical protein 0.0007 0.0105 0.0121
Onchocerca volvulus 0.0007 0.0109 0.0112
Trichomonas vaginalis sugar transporter, putative 0.0007 0.0105 0.0102
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0026 0.0749 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0105 0.0121
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.0016 0.0016
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0016 0.0395 0.0518
Schistosoma mansoni hypothetical protein 0.0005 0.0016 0.0016
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0033 0.0993 0.0978
Onchocerca volvulus 0.0248 0.8365 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0109 0.0128
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.0749 0.1002
Echinococcus granulosus solute carrier family 22 0.0007 0.0105 0.0089
Leishmania major phosphatidylinositol kinase related protein, putative 0.0019 0.0508 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0019 0.0507 0.0507
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0012 0.0266 0.0343
Schistosoma mansoni alpha-1 adrenergic receptor 0.0005 0.0016 0.0016
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.0749 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0224 0.0245
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0007 0.0109 0.0128
Trichomonas vaginalis sugar transporter, putative 0.0007 0.0105 0.0102
Plasmodium vivax lysine--tRNA ligase, putative 0.0011 0.0249 0.0201
Onchocerca volvulus 0.0007 0.0105 0.0106
Schistosoma mansoni neuropeptide F-like receptor 0.0005 0.0016 0.0016
Onchocerca volvulus 0.0007 0.0105 0.0106
Schistosoma mansoni glucose transport protein 0.0051 0.161 0.161
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0944 0.1786
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0007 0.0109 0.0094
Schistosoma mansoni sugar transporter 0.0007 0.0105 0.0105
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0507 0.0584
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0224 0.0245
Schistosoma mansoni glucose transport protein 0.0051 0.161 0.161
Loa Loa (eye worm) hypothetical protein 0.0007 0.0105 0.0121
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0019 0.0507 0.6241
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0007 0.0109 0.0128
Echinococcus multilocularis ecdysone induced protein 78C 0.0007 0.0109 0.0094
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0019 0.0507 0.9969
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0051 0.161 0.1596
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0402 0.0457
Brugia malayi lysyl-tRNA synthetase 0.0011 0.0249 0.0319
Schistosoma mansoni hypothetical protein 0.0123 0.406 0.406
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0395 0.0395
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0007 0.0109 0.0109
Trichomonas vaginalis sugar transporter, putative 0.0007 0.0105 0.0102
Trichomonas vaginalis sugar transporter, putative 0.0007 0.0105 0.0102
Schistosoma mansoni hypothetical protein 0.0296 1 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0018 0.0471 0.5684
Trichomonas vaginalis sugar transporter, putative 0.0007 0.0105 0.0102
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0507 0.0584
Onchocerca volvulus 0.0007 0.0105 0.0106
Schistosoma mansoni fkbp-rapamycin associated protein 0.0011 0.0224 0.0224
Trichomonas vaginalis sugar transporter, putative 0.0007 0.0105 0.0102
Onchocerca volvulus 0.0007 0.0105 0.0106
Giardia lamblia Prolyl-tRNA synthetase 0.0015 0.0384 0.6942
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0015 0.0384 0.0503
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0105 0.0102
Brugia malayi Sugar transporter family protein 0.0007 0.0105 0.0121
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0019 0.0507 0.0492
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0016 0.0395 0.0404
Leishmania major glucose transporter, lmgt2 0.0016 0.0402 0.7359
Onchocerca volvulus 0.0007 0.0105 0.0106
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0019 0.0507 0.9969
Loa Loa (eye worm) hypothetical protein 0.0007 0.0105 0.0121
Brugia malayi ecdysteroid receptor 0.0007 0.0109 0.0128
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0016 0.0395 0.0379
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0007 0.0109 0.0094
Loa Loa (eye worm) hypothetical protein 0.0089 0.2896 0.3935
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0006 0.0075 0.0059
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0016 0.0395 0.0379
Schistosoma mansoni myosin xvIII 0.0005 0.0016 0.0016
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0026 0.0751 0.0736
Onchocerca volvulus 0.0007 0.0105 0.0106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0224 0.0245
Loa Loa (eye worm) hypothetical protein 0.0022 0.0624 0.0831
Brugia malayi cytoplasmic intermediate filament protein 0.001 0.0217 0.0274
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0018 0.0471 0.5684
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0005 0.0016 0.0016
Echinococcus multilocularis musashi 0.002 0.0527 0.0512
Leishmania major glucose transporter, lmgt1 0.0016 0.0402 0.7359
Schistosoma mansoni retinoic acid receptor RXR 0.0007 0.0109 0.0109
Brugia malayi hypothetical protein 0.0007 0.0105 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0007 0.0109 0.0128
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0016 0.0395 0.0379
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0019 0.0507 0.6241
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0011 0.0249 0.2245
Leishmania major glucose transporter, lmgt3 0.0016 0.0402 0.7359
Mycobacterium ulcerans sugar transporter 0.0007 0.0105 0.2954
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0007 0.0109 0.0128
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0016 0.0395 0.0617
Schistosoma mansoni RAR-like nuclear receptor 0.0007 0.0109 0.0109
Brugia malayi steroid hormone receptor 0.0007 0.0109 0.0128
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0507 0.0584
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0033 0.0993 0.0978
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0507 0.0671
Entamoeba histolytica protein kinase, putative 0.0016 0.0395 0.324
Giardia lamblia GTOR 0.0019 0.0507 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0007 0.0109 0.0128
Trypanosoma brucei glucose transporter, putative 0.0016 0.0402 0.4607
Entamoeba histolytica hypothetical protein 0.0026 0.0751 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0018 0.0471 0.5684
Plasmodium falciparum calcium-dependent protein kinase 5 0.0016 0.0395 0.0404
Trichomonas vaginalis sugar transporter, putative 0.0007 0.0105 0.0102

Activities

Activity type Activity value Assay description Source Reference
Ki app (binding) = 9 uM Inhibition constant against peptidyl prolyl isomerase ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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