Detailed information for compound 1802544

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 536.528 | Formula: C32H24O8
  • H donors: 2 H acceptors: 5 LogP: 5.11 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 2
  • SMILES: Cc1cc2c(cc1C)oc(=O)c(c2O)C(c1coc2c(c1=O)cccc2)c1c(=O)oc2c(c1O)cc(c(c2)C)C
  • InChi: 1S/C32H24O8/c1-14-9-19-23(11-16(14)3)39-31(36)26(29(19)34)25(21-13-38-22-8-6-5-7-18(22)28(21)33)27-30(35)20-10-15(2)17(4)12-24(20)40-32(27)37/h5-13,25,34-35H,1-4H3
  • InChiKey: MTOHAWYRGURNTG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tubulin alpha chain 0.0179 0.1447 0.7436
Leishmania major beta tubulin 0.0237 0.1945 0.732
Trypanosoma brucei alpha tubulin 0.0179 0.1447 0.5397
Schistosoma mansoni tubulin subunit beta 0.0056 0.038 0.1954
Brugia malayi Tubulin alpha chain 0.0179 0.1447 0.1998
Echinococcus granulosus tubulin subunit beta 0.0237 0.1945 1
Leishmania major gamma-tubulin 0.0128 0.1007 0.3791
Brugia malayi exodeoxyribonuclease III family protein 0.0015 0.0027 0.0037
Trypanosoma brucei epsilon tubulin 0.0128 0.1007 0.3728
Giardia lamblia Gamma tubulin 0.0128 0.1007 0.3728
Trypanosoma cruzi epsilon tubulin, putative 0.0128 0.1007 0.3728
Echinococcus multilocularis tubulin alpha chain 0.0179 0.1447 0.7436
Toxoplasma gondii alpha-tubulin I, putative 0.0179 0.1447 0.5443
Trichomonas vaginalis tubulin gamma chain, putative 0.0128 0.1007 0.5179
Plasmodium vivax tubulin alpha chain, putative 0.0179 0.1447 0.5443
Loa Loa (eye worm) hypothetical protein 0.0107 0.0819 0.4211
Leishmania major beta tubulin 0.0237 0.1945 0.732
Echinococcus granulosus alpha tubulin 0.0179 0.1447 0.7436
Schistosoma mansoni tubulin subunit alpha 0.0179 0.1447 0.7436
Leishmania major alpha tubulin 0.0179 0.1447 0.5443
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0015 0.0027 0.0101
Brugia malayi alpha-tubulin 0.0179 0.1447 0.1998
Trichomonas vaginalis tubulin beta chain, putative 0.0073 0.0526 0.2704
Brugia malayi beta-tubulin, identical 0.0237 0.1945 0.2687
Echinococcus multilocularis beta tubulin 0.0237 0.1945 1
Plasmodium falciparum alpha tubulin 1 0.0179 0.1447 0.5443
Giardia lamblia Beta tubulin 0.0237 0.1945 0.7293
Echinococcus granulosus tubulin beta 4A class IVa 0.0237 0.1945 1
Giardia lamblia Alpha-tubulin 0.0179 0.1447 0.5397
Trichomonas vaginalis tubulin beta chain, putative 0.0179 0.1447 0.7436
Brugia malayi Cell division protein ftsZ 0.0056 0.038 0.0525
Toxoplasma gondii beta tubulin 0.0237 0.1945 0.732
Echinococcus granulosus tubulin alpha chain 0.0179 0.1447 0.7436
Schistosoma mansoni alpha tubulin 0.0179 0.1447 0.7436
Giardia lamblia Telomerase catalytic subunit 0.0319 0.2658 1
Trypanosoma brucei zeta tubulin 0.0056 0.038 0.1343
Loa Loa (eye worm) tubulin beta-4 chain 0.0237 0.1945 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0056 0.038 0.1954
Loa Loa (eye worm) tubulin alpha 2 0.0123 0.0965 0.4961
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0015 0.0027 0.0138
Echinococcus multilocularis tubulin epsilon chain 0.0128 0.1007 0.5179
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0015 0.0027 0.0705
Plasmodium vivax tubulin epsilon chain, putative 0.0128 0.1007 0.3791
Schistosoma mansoni ap endonuclease 0.0015 0.0027 0.0138
Echinococcus granulosus Tubulin beta 2C chain 0.0237 0.1945 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0237 0.1945 1
Brugia malayi Tubulin alpha-2 chain 0.0179 0.1447 0.1998
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0123 0.0965 0.4961
Echinococcus multilocularis peroxisome assembly protein 26 0.0179 0.1447 0.7436
Trypanosoma brucei beta tubulin 0.0237 0.1945 0.7293
Echinococcus multilocularis tubulin alpha chain 0.0179 0.1447 0.7436
Leishmania major alpha tubulin 0.0179 0.1447 0.5443
Echinococcus granulosus tubulin alpha chain 0.0179 0.1447 0.7436
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0123 0.0965 0.4961
Loa Loa (eye worm) alpha-tubulin 0.0179 0.1447 0.7436
Mycobacterium leprae cell division protein FtsZ 0.0056 0.038 0.5
Echinococcus granulosus Tubulin beta 2C chain 0.0237 0.1945 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0056 0.038 0.1954
Trichomonas vaginalis tubulin beta chain, putative 0.0179 0.1447 0.7436
Plasmodium vivax tubulin beta chain, putative 0.0237 0.1945 0.732
Loa Loa (eye worm) tubulin alpha-3 chain 0.0107 0.0819 0.4211
Trypanosoma cruzi zeta tubulin, putative 0.0056 0.038 0.1343
Leishmania major epsilon tubulin, putative 0.0128 0.1007 0.3791
Trichomonas vaginalis tubulin epsilon chain, putative 0.0237 0.1945 1
Echinococcus granulosus beta tubulin 0.0237 0.1945 1
Leishmania major beta tubulin 0.0237 0.1945 0.732
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0015 0.0027 0.0138
Giardia lamblia Alpha-tubulin 0.0179 0.1447 0.5397
Entamoeba histolytica tubulin gamma chain 0.0128 0.1007 0.5179
Trypanosoma cruzi tubulin gamma chain 0.0128 0.1007 0.3728
Plasmodium vivax delta tubulin, putative 0.0056 0.038 0.143
Echinococcus granulosus tubulin alpha chain 0.0179 0.1447 0.7436
Brugia malayi Tubulin beta chain 0.0056 0.038 0.0525
Echinococcus multilocularis tubulin alpha 1C chain 0.0179 0.1447 0.7436
Trichomonas vaginalis tubulin alpha chain, putative 0.0237 0.1945 1
Echinococcus granulosus tubulin beta 1 chain 0.0237 0.1945 1
Trypanosoma cruzi epsilon tubulin, putative 0.0128 0.1007 0.3728
Schistosoma mansoni tubulin subunit beta 0.0237 0.1945 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0179 0.1447 0.7436
Echinococcus granulosus Tubulin alpha 1 chain 0.0179 0.1447 0.7436
Toxoplasma gondii beta-tubulin, putative 0.0237 0.1945 0.732
Loa Loa (eye worm) BEN-1 protein 0.0237 0.1945 1
Echinococcus multilocularis beta tubulin 0.0237 0.1945 1
Schistosoma mansoni tubulin subunit gamma 0.0128 0.1007 0.5179
Echinococcus multilocularis Tubulin alpha 1 chain 0.0179 0.1447 0.7436
Leishmania major telomerase reverse transcriptase, putative 0.0319 0.2658 1
Toxoplasma gondii RNA-directed DNA polymerase 0.0319 0.2658 1
Trichomonas vaginalis ap endonuclease, putative 0.0015 0.0027 0.0138
Echinococcus multilocularis tubulin alpha 1C chain 0.0179 0.1447 0.7436
Toxoplasma gondii beta-1 tubulin, putative 0.0237 0.1945 0.732
Trichomonas vaginalis tubulin alpha chain, putative 0.0073 0.0526 0.2704
Schistosoma mansoni tubulin subunit alpha 0.0056 0.038 0.1954
Trypanosoma brucei epsilon tubulin 0.0128 0.1007 0.3728
Leishmania major alpha tubulin 0.0179 0.1447 0.5443
Trichomonas vaginalis tubulin, putative 0.0073 0.0526 0.2704
Trichomonas vaginalis tubulin beta chain, putative 0.0179 0.1447 0.7436
Echinococcus granulosus Tubulin beta 2C chain 0.0237 0.1945 1
Echinococcus multilocularis tubulin subunit beta 0.0237 0.1945 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0179 0.1447 0.7436
Leishmania major alpha tubulin 0.0179 0.1447 0.5443
Echinococcus granulosus tubulin subunit TubB 0.0179 0.1447 0.7436
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0015 0.0027 0.0138
Trichomonas vaginalis tubulin beta chain, putative 0.0179 0.1447 0.7436
Echinococcus multilocularis tubulin alpha chain 0.0179 0.1447 0.7436
Trypanosoma brucei alpha tubulin 0.0179 0.1447 0.5397
Entamoeba histolytica tubulin alpha chain, putative 0.0179 0.1447 0.7436
Leishmania major alpha tubulin 0.0179 0.1447 0.5443
Leishmania major beta tubulin 0.0237 0.1945 0.732
Echinococcus granulosus tubulin alpha 0.0128 0.1007 0.5179
Echinococcus granulosus tubulin epsilon chain 0.0128 0.1007 0.5179
Echinococcus granulosus tubulin alpha 3 chain 0.0179 0.1447 0.7436
Loa Loa (eye worm) tubulin beta chain 0.0237 0.1945 1
Trypanosoma brucei alpha tubulin, putative 0.0073 0.0526 0.1898
Plasmodium falciparum tubulin beta chain 0.0237 0.1945 0.732
Echinococcus multilocularis hypothetical protein 0.0179 0.1447 0.7436
Loa Loa (eye worm) hypothetical protein 0.0179 0.1447 0.7436
Trichomonas vaginalis tubulin, putative 0.0056 0.038 0.1954
Echinococcus granulosus tubulin delta chain 0.0056 0.038 0.1954
Leishmania major beta tubulin 0.0237 0.1945 0.732
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0056 0.038 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0179 0.1447 0.7436
Loa Loa (eye worm) tubulin gamma chain 0.0128 0.1007 0.5179
Trichomonas vaginalis tubulin, putative 0.0073 0.0526 0.2704
Loa Loa (eye worm) BEN-1 protein 0.0237 0.1945 1
Trypanosoma cruzi beta tubulin, putative 0.0237 0.1945 0.7293
Toxoplasma gondii alpha tubulin TUBA1 0.0179 0.1447 0.5443
Schistosoma mansoni tubulin subunit beta 0.0237 0.1945 1
Leishmania major alpha tubulin 0.0179 0.1447 0.5443
Plasmodium vivax tubulin gamma chain, putative 0.0128 0.1007 0.3791
Entamoeba histolytica tubulin family protein 0.0237 0.1945 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0015 0.0027 0.0101
Trichomonas vaginalis tubulin alpha chain, putative 0.0073 0.0526 0.2704
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0179 0.1447 0.7436
Trypanosoma brucei beta tubulin 0.0237 0.1945 0.7293
Entamoeba histolytica tubulin family protein 0.0237 0.1945 1
Leishmania major zeta tubulin, putative 0.0056 0.038 0.143
Toxoplasma gondii exonuclease III APE 0.0015 0.0027 0.0101
Echinococcus granulosus peroxisome assembly protein 26 0.0179 0.1447 0.7436
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0128 0.1007 0.3791
Leishmania major beta tubulin 0.0237 0.1945 0.732
Plasmodium vivax telomerase reverse transcriptase, putative 0.0319 0.2658 1
Loa Loa (eye worm) tubulin beta-1 chain 0.0237 0.1945 1
Loa Loa (eye worm) beta-tubulin 0.0237 0.1945 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0073 0.0526 0.2704
Trypanosoma cruzi alpha tubulin, putative 0.0179 0.1447 0.5397
Echinococcus granulosus Tubulin beta 2C chain 0.0237 0.1945 1
Leishmania major beta tubulin 0.0237 0.1945 0.732
Loa Loa (eye worm) tubulin alpha chain 0.0179 0.1447 0.7436
Loa Loa (eye worm) tubulin alpha 2 0.0051 0.0338 0.1736
Echinococcus granulosus tubulin alpha chain 0.0179 0.1447 0.7436
Echinococcus multilocularis tubulin alpha chain 0.0179 0.1447 0.7436
Trypanosoma cruzi tubulin delta chain 0.0056 0.038 0.1343
Echinococcus granulosus beta tubulin 0.0237 0.1945 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0128 0.1007 0.5179
Trypanosoma brucei epsilon tubulin 0.0128 0.1007 0.3728
Echinococcus multilocularis tubulin gamma 1 chain 0.0128 0.1007 0.5179
Trypanosoma brucei zeta tubulin, putative 0.0056 0.038 0.1343
Loa Loa (eye worm) tubulin beta-2A chain 0.0237 0.1945 1
Trypanosoma brucei tubulin delta chain 0.0056 0.038 0.1343
Schistosoma mansoni tubulin subunit alpha 0.0179 0.1447 0.7436
Echinococcus granulosus tubulin alpha chain 0.0179 0.1447 0.7436
Loa Loa (eye worm) tubulin alpha chain 0.0179 0.1447 0.7436
Plasmodium falciparum telomerase reverse transcriptase 0.0319 0.2658 1
Trypanosoma brucei beta tubulin 0.0128 0.1007 0.3728
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0319 0.2658 1
Schistosoma mansoni tubulin subunit delta 0.0056 0.038 0.1954
Loa Loa (eye worm) alpha-tubulin 0.0179 0.1447 0.7436
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0237 0.1945 1
Brugia malayi tubulin alpha chain - mouse 0.0179 0.1447 0.1998
Leishmania major beta tubulin 0.0237 0.1945 0.732
Leishmania major alpha tubulin 0.0179 0.1447 0.5443
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.038 0.1954
Brugia malayi Tubulin beta-1 chain 0.0237 0.1945 0.2687
Trypanosoma cruzi zeta tubulin, putative 0.0056 0.038 0.1343
Echinococcus multilocularis Tubulin alpha 1 chain 0.0179 0.1447 0.7436
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0319 0.2658 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0179 0.1447 0.7436
Trypanosoma brucei beta tubulin 0.0237 0.1945 0.7293
Trichomonas vaginalis tubulin epsilon chain, putative 0.0237 0.1945 1
Brugia malayi Tubulin beta chain 0.0073 0.0526 0.0726
Echinococcus granulosus tubulin alpha 1C chain 0.0179 0.1447 0.7436
Schistosoma mansoni tubulin subunit beta 0.0237 0.1945 1
Brugia malayi Tubulin alpha-2 chain 0.0179 0.1447 0.1998
Giardia lamblia Beta tubulin 0.0237 0.1945 0.7293
Schistosoma mansoni alpha tubulin 0.0179 0.1447 0.7436
Leishmania major beta tubulin 0.0237 0.1945 0.732
Leishmania major beta tubulin 0.0237 0.1945 0.732
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0056 0.038 0.1954
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0073 0.0526 0.2704
Echinococcus granulosus Tubulin beta 2C chain 0.0237 0.1945 1
Echinococcus multilocularis tubulin alpha 0.0128 0.1007 0.5179
Treponema pallidum cell division protein FtsZ 0.0056 0.038 1
Plasmodium vivax tubulin alpha chain, putative 0.0179 0.1447 0.5443
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0015 0.0027 0.0101
Mycobacterium ulcerans cell division protein FtsZ 0.0056 0.038 1
Trypanosoma brucei beta tubulin 0.0237 0.1945 0.7293
Entamoeba histolytica tubulin alpha-1 chain 0.0179 0.1447 0.7436
Loa Loa (eye worm) tubulin alpha 2 0.0123 0.0965 0.4961
Echinococcus multilocularis Tubulin beta 2C chain 0.0237 0.1945 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0237 0.1945 1
Trichomonas vaginalis ap endonuclease, putative 0.0015 0.0027 0.0138
Echinococcus multilocularis Tubulin beta 2C chain 0.0237 0.1945 1
Schistosoma mansoni tubulin subunit epsilon 0.0128 0.1007 0.5179
Echinococcus multilocularis Tubulin beta 2C chain 0.0237 0.1945 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0179 0.1447 0.7436
Leishmania major beta tubulin 0.0237 0.1945 0.732
Leishmania major beta tubulin 0.0237 0.1945 0.732
Onchocerca volvulus 0.0073 0.0526 0.0526
Echinococcus granulosus tubulin alpha 3 chain 0.0179 0.1447 0.7436
Leishmania major beta tubulin 0.0237 0.1945 0.732
Echinococcus multilocularis tubulin subunit TubB 0.0179 0.1447 0.7436
Trypanosoma brucei alpha tubulin 0.0179 0.1447 0.5397
Mycobacterium tuberculosis Cell division protein FtsZ 0.0056 0.038 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0056 0.038 0.143
Leishmania major alpha tubulin 0.0179 0.1447 0.5443
Echinococcus multilocularis tubulin delta chain 0.0056 0.038 0.1954
Leishmania major beta tubulin 0.0237 0.1945 0.732
Leishmania major beta tubulin 0.0237 0.1945 0.732
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.038 0.1954
Leishmania major delta tubulin, putative 0.0056 0.038 0.143
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0012 0 0.5
Plasmodium falciparum tubulin epsilon chain, putative 0.0128 0.1007 0.3791
Schistosoma mansoni tubulin subunit beta 0.0237 0.1945 1
Echinococcus granulosus tubulin gamma 1 chain 0.0128 0.1007 0.5179
Plasmodium falciparum tubulin delta chain, putative 0.0056 0.038 0.143
Trypanosoma brucei alpha tubulin 0.0179 0.1447 0.5397
Trichomonas vaginalis tubulin epsilon chain, putative 0.0179 0.1447 0.7436
Loa Loa (eye worm) hypothetical protein 0.0123 0.0965 0.4961
Schistosoma mansoni ap endonuclease 0.0015 0.0027 0.0138
Plasmodium falciparum alpha tubulin 2 0.0179 0.1447 0.5443
Echinococcus multilocularis Tubulin beta 2C chain 0.0237 0.1945 1
Leishmania major beta tubulin 0.0237 0.1945 0.732
Echinococcus multilocularis tubulin alpha 3 chain 0.0179 0.1447 0.7436
Trichomonas vaginalis tubulin, putative 0.0237 0.1945 1
Echinococcus multilocularis tubulin beta 1 chain 0.0237 0.1945 1
Giardia lamblia Beta tubulin 0.0237 0.1945 0.7293
Echinococcus granulosus tubulin alpha 1C chain 0.0179 0.1447 0.7436
Brugia malayi Tubulin gamma chain 0.0128 0.1007 0.1391
Leishmania major alpha tubulin 0.0179 0.1447 0.5443
Brugia malayi Tubulin alpha chain 0.0056 0.038 0.0525
Trypanosoma cruzi tubulin delta chain 0.0056 0.038 0.1343
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0056 0.038 0.143
Leishmania major alpha tubulin 0.0179 0.1447 0.5443
Brugia malayi tubulin alpha-2 chain 0.0179 0.1447 0.1998
Leishmania major alpha tubulin 0.0179 0.1447 0.5443
Loa Loa (eye worm) tubulin alpha-2 chain 0.0179 0.1447 0.7436
Leishmania major alpha tubulin 0.0179 0.1447 0.5443
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0015 0.0027 0.0138
Trypanosoma brucei telomerase reverse transcriptase 0.0319 0.2658 1
Giardia lamblia Epsilon tubulin 0.0056 0.038 0.1343
Leishmania major beta tubulin 0.0237 0.1945 0.732
Brugia malayi Telomerase reverse transcriptase 0.085 0.7241 1
Trichomonas vaginalis tubulin beta chain, putative 0.0179 0.1447 0.7436
Trichomonas vaginalis tubulin alpha chain, putative 0.0128 0.1007 0.5179
Trypanosoma brucei tubulin gamma chain 0.0128 0.1007 0.3728
Loa Loa (eye worm) tubulin beta chain 0.0056 0.038 0.1954
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0107 0.0819 0.4211
Schistosoma mansoni tubulin subunit beta 0.0237 0.1945 1
Giardia lamblia Delta tubulin 0.0056 0.038 0.1343
Leishmania major beta tubulin 0.0237 0.1945 0.732
Trichomonas vaginalis tubulin beta chain, putative 0.0237 0.1945 1
Schistosoma mansoni tubulin subunit beta 0.0237 0.1945 1
Schistosoma mansoni alpha tubulin 0.0179 0.1447 0.7436
Schistosoma mansoni tubulin subunit alpha 0.0179 0.1447 0.7436
Plasmodium falciparum tubulin gamma chain 0.0128 0.1007 0.3791
Trichomonas vaginalis tubulin beta chain, putative 0.0179 0.1447 0.7436

Activities

Activity type Activity value Assay description Source Reference
IZ (functional) = 20.8 mm Antibacterial activity against Escherichia coli ATCC 25922 assessed as growth inhibition after 24 hr by disk diffusion assay ChEMBL. No reference
IZ (functional) = 27.2 mm Antifungal activity against Candida albicans assessed as growth inhibition after 3 to 4 days by disk diffusion assay ChEMBL. No reference
MBC (functional) = 50 ug ml-1 Bactericidal activity against Escherichia coli ATCC 25922 after 18 to 24 hr ChEMBL. No reference
MFC (functional) = 25 ug ml-1 Fungicidal activity against Candida albicans after 48 hr ChEMBL. No reference
MIC (functional) = 12.5 ug ml-1 Antifungal activity against Candida albicans assessed as growth inhibition after 48 hr by macrodilution method ChEMBL. No reference
MIC (functional) = 25 ug ml-1 Antibacterial activity against Escherichia coli ATCC 25922 assessed as growth inhibition after 24 hr by macrodilution method ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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