Detailed information for compound 1805007

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1467.74 | Formula: C54H106N12O26S4
  • H donors: 24 H acceptors: 12 LogP: -15.14 Rotable bonds: 33
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCC1O[C@@H](O[C@@H]2[C@@H](CSCCOCCSSCCOCCSC[C@H]3O[C@H]([C@@H]([C@@H]3O[C@H]3OC(CN)[C@H]([C@@H]([C@H]3N)O)O)O)O[C@H]3[C@H](O)[C@@H](N)C[C@H]([C@@H]3O[C@H]3O[C@H](CN)[C@H]([C@@H]([C@H]3N)O)O)N)O[C@H]([C@@H]2O)O[C@H]2[C@H](O)[C@@H](N)C[C@H]([C@@H]2O[C@H]2O[C@H](CN)[C@H]([C@@H]([C@H]2N)O)O)N)[C@H]([C@@H]([C@H]1O)O)N
  • InChi: 1S/C54H106N12O26S4/c55-11-21-33(69)37(73)27(63)49(81-21)87-43-19(61)9-17(59)31(67)47(43)91-53-41(77)45(89-51-29(65)39(75)35(71)23(13-57)83-51)25(85-53)15-93-5-1-79-3-7-95-96-8-4-80-2-6-94-16-26-46(90-52-30(66)40(76)36(72)24(14-58)84-52)42(78)54(86-26)92-48-32(68)18(60)10-20(62)44(48)88-50-28(64)38(74)34(70)22(12-56)82-50/h17-54,67-78H,1-16,55-66H2/t17-,18-,19+,20+,21+,22+,23?,24?,25+,26+,27+,28+,29-,30+,31+,32+,33+,34+,35-,36+,37+,38+,39-,40+,41+,42+,43-,44-,45+,46+,47-,48-,49+,50+,51-,52+,53-,54-/m0/s1
  • InChiKey: AVTMARLPEJHNSQ-ZAPUGHGMSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Echinococcus multilocularis serotonin receptor 0.0131 0.0646 0.0646
Trypanosoma brucei hypothetical protein 0.0135 0.0671 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.0186 0.0847
Schistosoma mansoni alpha-1 adrenergic receptor 0.0131 0.0646 0.0646
Mycobacterium ulcerans hypothetical protein 0.1526 1 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0125 0.0795
Schistosoma mansoni neuropeptide receptor 0.0131 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0131 0.0646 0.0646
Schistosoma mansoni hypothetical protein 0.0169 0.0895 0.0895
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0135 0.0671 1
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Loa Loa (eye worm) neuropeptide F receptor 0.0131 0.0646 0.0646
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0011 0.0067
Brugia malayi Calcitonin receptor-like protein seb-1 0.0199 0.1099 0.4995
Echinococcus multilocularis rhodopsin orphan GPCR 0.0131 0.0646 0.0646
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0131 0.0646 0.0646
Plasmodium falciparum thioredoxin reductase 0.0047 0.0077 0.4378
Echinococcus granulosus neuropeptides capa receptor 0.0131 0.0646 0.0646
Brugia malayi G protein-coupled receptor 0.0131 0.0646 0.2935
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0011 0.5
Schistosoma mansoni hypothetical protein 0.0063 0.0186 0.0186
Echinococcus granulosus rhodopsin orphan GPCR 0.0131 0.0646 0.0646
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0036 0.0003 0.0039
Schistosoma mansoni cytochrome P450 0.0036 0.0003 0.0003
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0201 0.0201
Trypanosoma brucei Sphingosine kinase 0.0059 0.0163 0.2426
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0011 0.0158
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Echinococcus granulosus rhodopsin orphan GPCR 0.0131 0.0646 0.0646
Echinococcus multilocularis neuropeptide receptor 0.0131 0.0646 0.0646
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0131 0.0646 0.0646
Onchocerca volvulus 0.0131 0.0646 1
Brugia malayi sulfakinin receptor protein 0.0131 0.0646 0.2935
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0054 0.0125 0.0795
Brugia malayi glutathione reductase 0.0047 0.0077 0.0351
Onchocerca volvulus 0.0131 0.0646 1
Schistosoma mansoni opsin-like receptor 0.0131 0.0646 0.0646
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0135 0.0671 1
Schistosoma mansoni hypothetical protein 0.0063 0.0186 0.0186
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0131 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Brugia malayi Dopamine receptor 0.0131 0.0646 0.2935
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Entamoeba histolytica diacylglycerol kinase, putative 0.0059 0.0163 0.0163
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0054 0.0125 0.057
Mycobacterium ulcerans diacylglycerol kinase 0.0059 0.0163 0.016
Echinococcus granulosus tachykinin peptides receptor 99D 0.0131 0.0646 0.0646
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0122 0.0583 0.3696
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0025 0.0157
Loa Loa (eye worm) cytochrome P450 family protein 0.0112 0.0517 0.0517
Brugia malayi Tachykinin-like peptides receptor 99D 0.0131 0.0646 0.2935
Trypanosoma cruzi cytochrome P450, putative 0.0053 0.0121 0.1801
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0122 0.0583 0.8687
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0059 0.0163 0.2426
Schistosoma mansoni glutaminase 0.027 0.1576 0.1576
Echinococcus multilocularis GPCR, family 2 0.0063 0.0186 0.0186
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0122 0.0583 0.3696
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0017 0.0017
Onchocerca volvulus 0.0131 0.0646 1
Schistosoma mansoni ap endonuclease 0.0037 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0136 0.0677 0.0677
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Schistosoma mansoni neuropeptide F-like receptor 0.0131 0.0646 0.0646
Mycobacterium ulcerans glutaminase 0.027 0.1576 0.1574
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0135 0.0671 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0053 0.0121 0.0121
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0201 0.0201
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0122 0.0583 0.3696
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0039 0.0025 0.0022
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0077 0.0077
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0131 0.0646 0.0646
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0135 0.0671 1
Loa Loa (eye worm) TAR-binding protein 0.0128 0.0621 0.0621
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0131 0.0646 0.0646
Trypanosoma brucei hypothetical protein, conserved 0.0059 0.0163 0.2426
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0256 0.0256
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0163 0.1032
Schistosoma mansoni neuropeptide f receptor 76f 0.0131 0.0646 0.0646
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0131 0.0646 0.0646
Schistosoma mansoni hypothetical protein 0.0073 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Brugia malayi hypothetical protein 0.0131 0.0646 0.2935
Trichomonas vaginalis conserved hypothetical protein 0.0167 0.0885 0.5619
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0039 0.0025 0.0022
Brugia malayi RE15519p 0.0131 0.0646 0.2935
Plasmodium vivax glutathione reductase, putative 0.0047 0.0077 0.4378
Echinococcus granulosus neuropeptide receptor A26 0.0577 0.3632 0.3632
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0122 0.0583 0.3696
Loa Loa (eye worm) CYP4Cod1 0.0053 0.0121 0.0121
Echinococcus granulosus tm gpcr rhodopsin 0.0131 0.0646 0.0646
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.0671 1
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0805 0.5165 0.5165
Echinococcus granulosus rhodopsin orphan GPCR 0.0131 0.0646 0.0646
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.0671 1
Echinococcus multilocularis fmrfamide receptor 0.0131 0.0646 0.0646
Echinococcus granulosus rhodopsin orphan GPCR 0.0131 0.0646 0.0646
Trypanosoma brucei calpain, putative 0.0135 0.0671 1
Trichomonas vaginalis bmru protein, putative 0.0059 0.0163 0.1032
Echinococcus multilocularis neuropeptides capa receptor 0.0131 0.0646 0.0646
Echinococcus multilocularis rhodopsin orphan GPCR 0.0131 0.0646 0.0646
Echinococcus granulosus allatostatin A receptor 0.0131 0.0646 0.0646
Schistosoma mansoni hypothetical protein 0.0169 0.0895 0.0895
Echinococcus granulosus neuropeptide FF receptor 2 0.0131 0.0646 0.0646
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0122 0.0583 0.3696
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Echinococcus granulosus g protein coupled receptor 0.0131 0.0646 0.0646
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.0478 0.8565
Trypanosoma cruzi cytochrome P450, putative 0.0053 0.0121 0.1801
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0201 0.2996
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0054 0.0125 0.0125
Trichomonas vaginalis bmru protein, putative 0.0059 0.0163 0.1032
Trypanosoma cruzi Sphingosine kinase 0.0059 0.0163 0.2426
Echinococcus granulosus g-protein coupled receptor 0.0131 0.0646 0.0646
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0059 0.0163 0.3376
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0131 0.0646 0.0646
Trypanosoma brucei diacylglycerol kinase, putative 0.0059 0.0163 0.2426
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0122 0.0583 0.3696
Schistosoma mansoni hypothetical protein 0.0131 0.0646 0.0646
Plasmodium falciparum glutathione reductase 0.0047 0.0077 0.4378
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0131 0.0646 0.0646
Echinococcus granulosus biogenic amine 5HT receptor 0.0131 0.0646 0.0646
Echinococcus granulosus rhodopsin orphan GPCR 0.0131 0.0646 0.0646
Echinococcus granulosus neuropeptides capa receptor 0.0131 0.0646 0.0646
Leishmania major hypothetical protein, conserved 0.0059 0.0163 0.2426
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Echinococcus granulosus serotonin receptor 0.0131 0.0646 0.0646
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0122 0.0583 0.3696
Onchocerca volvulus 0.0131 0.0646 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0201 0.2996
Loa Loa (eye worm) glutaminase 2 0.027 0.1576 0.1576
Echinococcus multilocularis rhodopsin orphan GPCR 0.0131 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Brugia malayi hypothetical protein 0.0131 0.0646 0.2935
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0039 0.0025 0.0022
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0122 0.0583 0.3696
Echinococcus granulosus neuropeptide Y receptor 0.0131 0.0646 0.0646
Brugia malayi latrophilin 2 splice variant baaae 0.0136 0.0677 0.3075
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.0478 0.0476
Schistosoma mansoni myosin xvIII 0.0131 0.0646 0.0646
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.0186 0.0186
Echinococcus granulosus dro:myosuppressin receptor 0.0131 0.0646 0.0646
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0131 0.0646 0.2935
Trichomonas vaginalis sphingosine kinase, putative 0.0059 0.0163 0.1032
Entamoeba histolytica hypothetical protein 0.0073 0.0256 0.0256
Echinococcus multilocularis orexin receptor type 2 0.0131 0.0646 0.0646
Brugia malayi diacylglycerol kinase 0.0059 0.0163 0.0739
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0122 0.0583 0.3696
Schistosoma mansoni neuropeptide F-like receptor 0.0131 0.0646 0.0646
Echinococcus granulosus lysosomal alpha glucosidase 0.0159 0.0828 0.0828
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.0558 0.0556
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0131 0.0646 0.0646
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0122 0.0583 0.8687
Schistosoma mansoni hypothetical protein 0.0131 0.0646 0.0646
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0077 0.0075
Onchocerca volvulus 0.0131 0.0646 1
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Brugia malayi hypothetical protein 0.0073 0.0256 0.1163
Onchocerca volvulus 0.0131 0.0646 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0131 0.0646 0.0646
Echinococcus granulosus ceramide kinase 0.0059 0.0163 0.0163
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0122 0.0583 0.3696
Onchocerca volvulus 0.0092 0.0379 0.448
Echinococcus granulosus alpha 1A adrenergic receptor 0.0131 0.0646 0.0646
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0201 0.0913
Loa Loa (eye worm) hypothetical protein 0.0199 0.1099 0.1099
Brugia malayi Cytochrome P450 family protein 0.0036 0.0003 0.0012
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0199 0.1099 0.1099
Schistosoma mansoni opsin-like receptor 0.0131 0.0646 0.0646
Toxoplasma gondii GAF domain-containing protein 0.0039 0.0025 0.0513
Echinococcus multilocularis sex peptide receptor 0.0131 0.0646 0.0646
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0135 0.0671 1
Schistosoma mansoni alpha-glucosidase 0.0136 0.068 0.068
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.0671 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0131 0.0646 0.0646
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0131 0.0646 0.0646
Brugia malayi Serotonin receptor 0.0131 0.0646 0.2935
Brugia malayi Eye-specific diacylglycerol kinase 0.0059 0.0163 0.0739
Entamoeba histolytica hypothetical protein 0.0073 0.0256 0.0256
Echinococcus granulosus neuropeptide s receptor 0.0577 0.3632 0.3632
Brugia malayi Diacylglycerol kinase protein 2 0.0059 0.0163 0.0739
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0122 0.0583 0.3696
Echinococcus multilocularis serotonin receptor 0.0131 0.0646 0.0646
Leishmania major sphingosine kinase A, B, putative 0.0059 0.0163 0.2426
Echinococcus granulosus tar DNA binding protein 0.0128 0.0621 0.0621
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0131 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0054 0.0125 0.0125
Schistosoma mansoni amine GPCR 0.0131 0.0646 0.0646
Echinococcus granulosus GPCR family 2 0.0063 0.0186 0.0186
Toxoplasma gondii exonuclease III APE 0.0037 0.0011 0.022
Loa Loa (eye worm) glutathione reductase 0.0047 0.0077 0.0077
Entamoeba histolytica diacylglycerol kinase, putative 0.0059 0.0163 0.0163
Echinococcus multilocularis sphingosine kinase 1 0.1526 1 1
Echinococcus multilocularis geminin 0.0169 0.0895 0.0895
Brugia malayi putative neuropeptide receptor 0.0131 0.0646 0.2935
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0083 0.0322 0.4798
Echinococcus multilocularis neuropeptide s receptor 0.0577 0.3632 0.3632
Schistosoma mansoni hypothetical protein 0.0063 0.0186 0.0186
Schistosoma mansoni adenoreceptor 0.0131 0.0646 0.0646
Trypanosoma cruzi diacylglycerol kinase, putative 0.0059 0.0163 0.2426
Loa Loa (eye worm) RNA binding protein 0.0128 0.0621 0.0621
Echinococcus granulosus geminin 0.0169 0.0895 0.0895
Brugia malayi Melatonin receptor type 1A 0.0131 0.0646 0.2935
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0083 0.0322 0.2042
Schistosoma mansoni amine GPCR 0.0131 0.0646 0.0646
Schistosoma mansoni hypothetical protein 0.0136 0.0677 0.0677
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0059 0.0163 0.2426
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0011 0.0011
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.0558 0.0556
Leishmania major hypothetical protein, conserved 0.0059 0.0163 0.2426
Brugia malayi Serotonin receptor 0.0131 0.0646 0.2935
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0059 0.0163 0.0163
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0011 0.0008
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0201 0.2996
Echinococcus multilocularis G-protein coupled receptor, putative 0.0131 0.0646 0.0646
Schistosoma mansoni biogenic amine (5HT) receptor 0.0131 0.0646 0.0646
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0122 0.0583 0.3696
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.0478 0.0476
Loa Loa (eye worm) ceramide kinase 0.0059 0.0163 0.0163
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0122 0.0583 0.3696
Loa Loa (eye worm) cytochrome P450 0.0036 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Schistosoma mansoni neuropeptide receptor 0.0131 0.0646 0.0646
Onchocerca volvulus 0.0131 0.0646 1
Plasmodium falciparum diacylglycerol kinase, putative 0.0059 0.0163 1
Brugia malayi hypothetical protein 0.0131 0.0646 0.2935
Toxoplasma gondii diacylglycerol kinase, putative 0.0059 0.0163 0.3376
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0036 0.0003 0.0039
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.0671 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0122 0.0583 0.8687
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0131 0.0646 0.0646
Schistosoma mansoni biogenic amine (5HT) receptor 0.0131 0.0646 0.0646
Loa Loa (eye worm) glutaminase 0.027 0.1576 0.1576
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0131 0.0646 0.0646
Schistosoma mansoni biogenic amine receptor 0.0131 0.0646 0.0646
Echinococcus granulosus Diacylglycerol kinase theta 0.0059 0.0163 0.0163
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0122 0.0583 0.3696
Leishmania major diacylglycerol kinase-like protein 0.0059 0.0163 0.2426
Trypanosoma cruzi hypothetical protein, conserved 0.0059 0.0163 0.2426
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0131 0.0646 0.0646
Echinococcus multilocularis fmrfamide receptor 0.0131 0.0646 0.0646
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0122 0.0583 0.8687
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0011 0.0008
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0122 0.0583 0.3696
Echinococcus multilocularis neuropeptide Y receptor 0.0131 0.0646 0.0646
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.0671 1
Schistosoma mansoni amine GPCR 0.0131 0.0646 0.0646
Trichomonas vaginalis sphingosine kinase, putative 0.0059 0.0163 0.1032
Schistosoma mansoni biogenic amine receptor 0.0131 0.0646 0.0646
Leishmania major trypanothione reductase 0.0047 0.0077 0.1151
Echinococcus multilocularis neuropeptides capa receptor 0.0131 0.0646 0.0646
Brugia malayi hypothetical protein 0.0131 0.0646 0.2935
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Brugia malayi hypothetical protein 0.0131 0.0646 0.2935
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0059 0.0163 0.0163
Echinococcus granulosus sex peptide receptor 0.0131 0.0646 0.0646
Echinococcus multilocularis g-protein coupled receptor 0.0131 0.0646 0.0646
Onchocerca volvulus 0.0131 0.0646 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0122 0.0583 0.3696
Leishmania major diacylglycerol kinase, putative 0.0059 0.0163 0.2426
Echinococcus granulosus Diacylglycerol kinase zeta 0.0059 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Entamoeba histolytica diacylglycerol kinase, putative 0.0059 0.0163 0.0163
Brugia malayi cytochrome P450 0.0036 0.0003 0.0012
Echinococcus multilocularis rhodopsin orphan GPCR 0.0131 0.0646 0.0646
Entamoeba histolytica hypothetical protein, conserved 0.1526 1 1
Onchocerca volvulus 0.0131 0.0646 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.0478 0.0476
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0053 0.0121 0.0118
Echinococcus multilocularis rhodopsin orphan GPCR 0.0131 0.0646 0.0646
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0131 0.0646 0.0646
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0054 0.0125 0.0125
Schistosoma mansoni ap endonuclease 0.0037 0.0011 0.0011
Echinococcus granulosus neuropeptide receptor 0.0131 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0077 0.0077
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0621 0.0621
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.0646 0.0646
Brugia malayi RNA recognition motif domain containing protein 0.0128 0.0621 0.2823
Schistosoma mansoni growth hormone secretagogue receptor 0.0131 0.0646 0.0646
Echinococcus granulosus orexin receptor type 2 0.0131 0.0646 0.0646
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0077 0.0077
Entamoeba histolytica diacylglycerol kinase, putative 0.0059 0.0163 0.0163
Onchocerca volvulus 0.0131 0.0646 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0186 0.0186
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0059 0.0163 0.0163
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0122 0.0583 0.3696
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0025 0.0398
Schistosoma mansoni hypothetical protein 0.0063 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Echinococcus granulosus cytochrome P450 2K1 0.0036 0.0003 0.0003
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0036 0.0003 0.0039
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0011 0.0048
Echinococcus multilocularis rhodopsin orphan GPCR 0.0131 0.0646 0.0646
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0122 0.0583 0.3696
Plasmodium falciparum GAF domain-related protein, putative 0.0039 0.0025 0.0929
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0131 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0172 0.0917 0.0917
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0131 0.0646 0.0646
Brugia malayi hypothetical protein 0.0131 0.0646 0.2935
Loa Loa (eye worm) hypothetical protein 0.0059 0.0163 0.0163
Brugia malayi hypothetical protein 0.0131 0.0646 0.2935
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0621 0.0621
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0201 0.0201
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0059 0.0163 0.1032
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0131 0.0646 0.0646
Schistosoma mansoni amine GPCR 0.0131 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Brugia malayi Dopamine receptor protein 1 0.0131 0.0646 0.2935
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0122 0.0583 0.3696
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0059 0.0163 0.3376
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0059 0.0163 0.0163
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0122 0.0583 0.3696
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0077 0.1151
Trypanosoma cruzi Sphingosine kinase 0.0059 0.0163 0.2426
Mycobacterium tuberculosis Conserved protein 0.1526 1 1
Trypanosoma brucei trypanothione reductase 0.0047 0.0077 0.1151
Echinococcus multilocularis G protein coupled receptor 139 0.0131 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Loa Loa (eye worm) G-protein coupled receptor 0.0131 0.0646 0.0646
Toxoplasma gondii hypothetical protein 0.0107 0.0482 1
Loa Loa (eye worm) TYRA-2 protein 0.0131 0.0646 0.0646
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.0186 0.0186
Mycobacterium ulcerans putative regulatory protein 0.0039 0.0025 0.0022
Plasmodium falciparum diacylglycerol kinase, putative 0.0059 0.0163 1
Echinococcus granulosus hypothetical protein 0.0131 0.0646 0.0646
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0011 0.0158
Echinococcus multilocularis neuropeptide receptor 0.0131 0.0646 0.0646
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.0558 0.0556
Brugia malayi ORL1-like opioid receptor 0.0131 0.0646 0.2935
Echinococcus granulosus 7TM GPCR rhodopsin 0.0131 0.0646 0.0646
Schistosoma mansoni diacylglycerol kinase theta 0.0059 0.0163 0.0163
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0131 0.0646 0.0646
Onchocerca volvulus 0.0131 0.0646 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0122 0.0583 0.3696
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0172 0.0917 0.4167
Plasmodium vivax diacylglycerol kinase, putative 0.0059 0.0163 1
Brugia malayi hypothetical protein 0.0131 0.0646 0.2935
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0122 0.0583 0.3696
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0131 0.0646 0.0646
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0135 0.0671 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0131 0.0646 0.2935
Schistosoma mansoni hypothetical protein 0.0131 0.0646 0.0646
Echinococcus granulosus 7tm_1 domain containing protein 0.0131 0.0646 0.0646
Mycobacterium tuberculosis Diacylglycerol kinase 0.0059 0.0163 0.016
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0482 0.3058
Brugia malayi hypothetical protein 0.0131 0.0646 0.2935
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0131 0.0646 0.0646
Trichomonas vaginalis diacylglycerol kinase, putative 0.0059 0.0163 0.1032
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.0646 0.0646
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0131 0.0646 0.0646
Echinococcus granulosus G protein coupled receptor 139 0.0131 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0131 0.0646 0.0646
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0122 0.0583 0.0583
Loa Loa (eye worm) diacylglycerol kinase 2 0.0059 0.0163 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0482 0.3058
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0128 0.0621 0.0621
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0122 0.0583 0.0583
Schistosoma mansoni neuropeptide receptor 0.0131 0.0646 0.0646
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0131 0.0646 0.0646
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0011 0.0011
Brugia malayi diacylglycerol kinase 0.0059 0.0163 0.0739
Echinococcus multilocularis Diacylglycerol kinase theta 0.0059 0.0163 0.0163
Echinococcus granulosus neuropeptide receptor 0.0131 0.0646 0.0646
Brugia malayi larval opioid receptor 0.0131 0.0646 0.2935
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0011 0.5
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0036 0.0003 0.0039
Brugia malayi G-protein coupled receptor 0.0131 0.0646 0.2935
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0059 0.0163 0.2426
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0077 0.4378
Echinococcus multilocularis neuropeptide FF receptor 2 0.0131 0.0646 0.0646
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0621 0.0621
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0135 0.0671 1
Brugia malayi GnHR receptor homolog 0.0131 0.0646 0.2935
Mycobacterium tuberculosis Probable reductase 0.0107 0.0478 0.0476
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0131 0.0646 0.0646
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0122 0.0583 0.0583
Loa Loa (eye worm) hypothetical protein 0.1526 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.0131 0.0646 0.0646
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0363 0.2201 0.2201
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0131 0.0646 0.0646
Plasmodium vivax diacylglycerol kinase, putative 0.0059 0.0163 1
Echinococcus multilocularis allatostatin A receptor 0.0131 0.0646 0.0646
Toxoplasma gondii hypothetical protein 0.0039 0.0025 0.0513
Echinococcus multilocularis dro:myosuppressin receptor 0.0131 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0482 0.3058
Onchocerca volvulus 0.0131 0.0646 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0131 0.0646 0.0646
Trypanosoma brucei calpain-like protein, putative 0.0135 0.0671 1
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Echinococcus multilocularis rhodopsin orphan GPCR 0.0131 0.0646 0.0646
Brugia malayi G protein-coupled receptor F59B2.13 0.0131 0.0646 0.2935
Leishmania major cytochrome p450-like protein 0.0036 0.0003 0.0039
Leishmania major cytochrome p450-like protein 0.0053 0.0121 0.1801
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.0478 0.0476
Echinococcus granulosus g protein coupled receptor 0.0131 0.0646 0.0646
Schistosoma mansoni sphingosine kinase A B 0.1526 1 1
Schistosoma mansoni hypothetical protein 0.0036 0.0003 0.0003
Schistosoma mansoni biogenic amine receptor 0.0131 0.0646 0.0646
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0131 0.0646 0.2935
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0059 0.0163 0.0163
Echinococcus granulosus neuropeptide Y receptor 0.0131 0.0646 0.0646
Toxoplasma gondii hypothetical protein 0.0039 0.0025 0.0513
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0122 0.0583 0.3696
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0054 0.0125 0.057
Onchocerca volvulus 0.0131 0.0646 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.0558 1
Echinococcus granulosus somatostatin receptor 0.0131 0.0646 0.0646
Brugia malayi Ceramide kinase 0.0059 0.0163 0.0739
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.0478 0.0476
Loa Loa (eye worm) hypothetical protein 0.0039 0.0025 0.0025
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0059 0.0163 0.0163
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0131 0.0646 0.0646
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0131 0.0646 0.2935
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.0828 0.0828
Brugia malayi AKH receptor 0.0131 0.0646 0.2935
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0131 0.0646 0.0646
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0131 0.0646 0.0646
Echinococcus multilocularis g protein coupled receptor 0.0131 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Schistosoma mansoni alpha-glucosidase 0.0136 0.068 0.068
Echinococcus granulosus tm gpcr rhodopsin 0.0131 0.0646 0.0646
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0011 0.0011
Echinococcus multilocularis 0.0036 0.0003 0.0003
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0011 0.0158
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0131 0.0646 0.0646
Brugia malayi Glycosyl hydrolases family 31 protein 0.0159 0.0828 0.3761
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Echinococcus multilocularis tar DNA binding protein 0.0128 0.0621 0.0621
Echinococcus granulosus biogenic amine 5HT receptor 0.0131 0.0646 0.0646
Brugia malayi Thioredoxin reductase 0.0047 0.0077 0.0351
Brugia malayi putative neuropeptide receptor NPR1 0.0131 0.0646 0.2935
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.0186 0.0186
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0199 0.1099 0.4995
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.0646 0.0646
Brugia malayi TAR-binding protein 0.0128 0.0621 0.2823
Loa Loa (eye worm) cytochrome P450 family protein 0.0053 0.0121 0.0121
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0122 0.0583 0.3696
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0059 0.0163 0.2426
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0054 0.0125 0.0125
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0011 0.0067
Schistosoma mansoni neuropeptide receptor 0.0131 0.0646 0.0646
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0135 0.0671 1
Brugia malayi Cytochrome P450 family protein 0.0053 0.0121 0.0549
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0201 0.0201
Brugia malayi glutaminase DH11.1 0.027 0.1576 0.7161
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0135 0.0671 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.0186 0.0186
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.0646 0.0646
Echinococcus multilocularis neuropeptide Y receptor 0.0131 0.0646 0.0646
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.0646 0.0646
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0036 0.0003 0.0039
Loa Loa (eye worm) hypothetical protein 0.0059 0.0163 0.0163
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0256 0.0256
Onchocerca volvulus 0.0131 0.0646 1
Echinococcus multilocularis neuropeptide receptor A26 0.0577 0.3632 0.3632
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0131 0.0646 0.0646
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0131 0.0646 0.0646
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0131 0.0646 0.2935
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0131 0.0646 0.0646
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0125 0.0795
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0011 0.0011
Echinococcus granulosus fmrfamide receptor 0.0131 0.0646 0.0646
Echinococcus multilocularis ceramide kinase 0.0059 0.0163 0.0163
Brugia malayi Latrophilin receptor protein 2 0.0063 0.0186 0.0847
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.0583 0.3696
Toxoplasma gondii thioredoxin reductase 0.0047 0.0077 0.1602
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0122 0.0583 0.3696
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0059 0.0163 0.1032
Brugia malayi Dopamine receptor protein 2 0.0131 0.0646 0.2935
Brugia malayi neuropeptide F receptor 0.0131 0.0646 0.2935
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0122 0.0583 0.3696
Echinococcus granulosus rhodopsin orphan GPCR 0.0131 0.0646 0.0646
Entamoeba histolytica hypothetical protein 0.0073 0.0256 0.0256
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0122 0.0583 0.3696
Onchocerca volvulus 0.0131 0.0646 1
Schistosoma mansoni sphingoid long chain base kinase 0.1526 1 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0131 0.0646 0.0646
Entamoeba histolytica hypothetical protein 0.0073 0.0256 0.0256
Echinococcus multilocularis somatostatin receptor 0.0131 0.0646 0.0646
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.0646 0.0646
Schistosoma mansoni opsin-like receptor 0.0131 0.0646 0.0646
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0122 0.0583 0.8687
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Schistosoma mansoni histamine h1 receptor 0.0131 0.0646 0.0646
Echinococcus multilocularis g protein coupled receptor 0.0131 0.0646 0.0646
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0059 0.0163 0.1032
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0201 0.0201
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.0646 0.0646
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0025 0.0929
Echinococcus granulosus tm gpcr rhodopsin 0.0131 0.0646 0.0646
Onchocerca volvulus 0.0131 0.0646 1
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0621 0.0621
Echinococcus multilocularis g protein coupled receptor 0.0131 0.0646 0.0646
Schistosoma mansoni hypothetical protein 0.0059 0.0163 0.0163
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0059 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Trichomonas vaginalis glutaminase, putative 0.027 0.1576 1
Echinococcus granulosus g protein coupled receptor 0.0131 0.0646 0.0646
Brugia malayi RNA binding protein 0.0128 0.0621 0.2823
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0011 0.5
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0083 0.0322 0.2042
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0159 0.0828 0.0828
Brugia malayi Cytochrome P450 family protein 0.0053 0.0121 0.0549
Brugia malayi neuropeptide F receptor 0.0131 0.0646 0.2935
Brugia malayi follicle stimulating hormone receptor 0.0363 0.2201 1
Schistosoma mansoni diacylglycerol kinase theta 0.0059 0.0163 0.0163
Toxoplasma gondii cytochrome p450 superfamily protein 0.0036 0.0003 0.0054
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.0186 0.0186
Echinococcus granulosus rhodopsin orphan GPCR 0.0131 0.0646 0.0646
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0621 0.0621
Schistosoma mansoni amine GPCR 0.0131 0.0646 0.0646
Schistosoma mansoni hypothetical protein 0.0131 0.0646 0.0646
Trypanosoma cruzi diacylglycerol kinase, putative 0.0059 0.0163 0.2426
Loa Loa (eye worm) hypothetical protein 0.0131 0.0646 0.0646
Loa Loa (eye worm) G-protein coupled receptor 0.0131 0.0646 0.0646
Brugia malayi hypothetical protein 0.0131 0.0646 0.2935
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0131 0.0646 1
Trichomonas vaginalis diacylglycerol kinase, putative 0.0059 0.0163 0.1032
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0017 0.0017
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0131 0.0646 0.0646
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0011 0.0158
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0131 0.0646 0.0646
Leishmania major cytochrome p450-like protein 0.0036 0.0003 0.0039
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.0828 0.0828
Brugia malayi G-protein coupled receptor 0.0131 0.0646 0.2935
Brugia malayi hypothetical protein 0.0059 0.0163 0.0739
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0131 0.0646 0.0646
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0122 0.0583 0.3696
Onchocerca volvulus 0.0131 0.0646 1
Mycobacterium ulcerans putative regulatory protein 0.0039 0.0025 0.0022
Trypanosoma brucei cytochrome P450, putative 0.0053 0.0121 0.1801
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0135 0.0671 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0131 0.0646 1
Brugia malayi Cytochrome P450 family protein 0.0112 0.0517 0.2351
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0201 0.2996

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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