TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 422.517 | Formula: C25H30N2O4
H donors: 2 H acceptors: 3 LogP: 3.68 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: N#Cc1ccc2c(c1)[C@H](NC(C(=O)OC(C)(C)C)Cc1ccccc1)[C@H](C(O2)(C)C)O
InChi: 1S/C25H30N2O4/c1-24(2,3)31-23(29)19(14-16-9-7-6-8-10-16)27-21-18-13-17(15-26)11-12-20(18)30-25(4,5)22(21)28/h6-13,19,21-22,27-28H,14H2,1-5H3/t19?,21-,22+/m0/s1
InChiKey: MOYJDVLMCUPZOS-YPURBLFUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ATP-binding cassette, sub-family B (MDR/TAP), member 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Plasmodium yoelii	multidrug resistance protein	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania donovani	p-glycoprotein	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania mexicana	p-glycoprotein	Get druggable targets OG5_126596	All targets in OG5_126596
Neospora caninum	hypothetical protein	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, half transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Plasmodium vivax	multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	abcb9, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma mansoni	smdr2	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania major	ATP-binding cassette protein subfamily B, member 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania donovani	ATP-binding cassette protein subfamily B, member 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 3, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Toxoplasma gondii	ATP-binding cassette transporter ABC.B1	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma mansoni	multidrug resistance protein	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein-2	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Bile salt export pump, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 3, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Onchocerca volvulus		Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	abcb9, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Brugia malayi	multidrug resistance protein 3	Get druggable targets OG5_126596	All targets in OG5_126596
Neospora caninum	ATP-binding cassette, sub-family B (MDR/TAP), member 4, related	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma mansoni	multidrug resistance protein	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	ATP binding cassette sub family B	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Loa Loa (eye worm)	multidrug resistance protein 3	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Candida albicans	potential ABC transporter similar to S. cerevisiae STE6 (YKL209C) involved in peptide pheromone export	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	taga, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein-1	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein-5	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein 5, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma mansoni	multidrug resistance protein	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, half transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein-2	Get druggable targets OG5_126596	All targets in OG5_126596
Plasmodium falciparum	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania braziliensis	p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	Get druggable targets OG5_126596	All targets in OG5_126596
Cryptosporidium parvum	ATP-binding cassette transporter	Get druggable targets OG5_126596	All targets in OG5_126596
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	Get druggable targets OG5_126596	All targets in OG5_126596
Plasmodium knowlesi	multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Cryptosporidium hominis	ATP-binding cassette protein 3	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	ATP-binding cassette sub-family B member 5, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania infantum	ATP-binding cassette protein subfamily B, member 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania major	p-glycoprotein	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania mexicana	p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glyco protein 6, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	Get druggable targets OG5_126596	All targets in OG5_126596
Plasmodium berghei	multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania infantum	p-glycoprotein	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Brugia malayi	ABC transporter family protein	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	ko:K05659 ATP-binding cassette, subfamily B (MDR/TAP), member 4, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	abcb9, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein-2, putative	Get druggable targets OG5_126596	All targets in OG5_126596

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	SRC-1	0.0057	0.0457	0.0662
Echinococcus multilocularis	AMPK beta subunit	0.0132	0.1451	0.1451
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0449	0.562	1
Toxoplasma gondii	5'-AMP-activated protein kinase subunit beta-1 family protein, putative	0.0078	0.0735	0.4348
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0781	1	1
Schistosoma mansoni	tyrosine kinase	0.0093	0.0929	0.0929
Schistosoma mansoni	chloride channel protein	0.0025	0.0029	0.0029
Trichomonas vaginalis	AGC family protein kinase	0.0056	0.0447	0.0423
Treponema pallidum	hemolysin (tlyC)	0.0025	0.0029	0.5
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.004	0.0232	0.0362
Echinococcus granulosus	serine/threonine protein kinase	0.004	0.0232	0.0232
Onchocerca volvulus		0.0781	1	1
Echinococcus multilocularis	serine threonine protein kinase	0.0024	0.0025	0.0025
Treponema pallidum	Mg2+ transport protein (mgtE)	0.0025	0.0029	0.5
Schistosoma mansoni	AMP-activated protein kinase gamma regulatory subunit	0.0025	0.0029	0.0029
Trypanosoma brucei	SNF1-related protein kinases, putative	0.006	0.0503	0.0848
Toxoplasma gondii	protein kinase, cAMP-dependent, catalytic chain	0.0148	0.1653	1
Brugia malayi	Hr1 repeat family protein	0.0024	0.0025	0.0025
Loa Loa (eye worm)	TK protein kinase	0.004	0.0228	0.033
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0056	0.0447	0.0646
Schistosoma mansoni	serine/threonine protein kinase	0.0203	0.2386	0.2386
Brugia malayi	protein kinase C II.	0.0024	0.0025	0.0025
Toxoplasma gondii	histone kinase SNF1, putative	0.006	0.0503	0.2917
Trypanosoma cruzi	SNF1-related protein kinases, putative	0.006	0.0503	0.0848
Leishmania major	protein kinase, putative,SNF1-related protein kinases, putative	0.006	0.0503	0.0848
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0067	0.0589	0.1002
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0449	0.562	0.562
Trichomonas vaginalis	CAMK family protein kinase	0.006	0.0503	0.0479
Schistosoma mansoni	tyrosine kinase	0.0023	0.0007	0.0007
Toxoplasma gondii	pyruvate dehydrogenase kinase, putative	0.0049	0.0347	0.1961
Trichomonas vaginalis	CAMK family protein kinase	0.006	0.0503	0.0479
Echinococcus granulosus	SNF4:AMP activated protein kinase gamma subunit	0.0025	0.0029	0.0029
Echinococcus multilocularis	roundabout 2	0.0032	0.0122	0.0122
Trichomonas vaginalis	AGC family protein kinase	0.0056	0.0447	0.0423
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0029	0.0042
Echinococcus multilocularis	H(+):Cl() exchange transporter 3	0.0025	0.0029	0.0029
Mycobacterium ulcerans	hypothetical protein	0.0781	1	1
Giardia lamblia	Transglutaminase/protease, putative	0.0781	1	1
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0056	0.0447	0.0646
Echinococcus granulosus	c src tyrosine kinase	0.0023	0.0007	0.0007
Plasmodium vivax	glycogen synthase kinase 3, putative	0.0064	0.0544	0.22
Echinococcus multilocularis	epidermal growth factor receptor	0.0179	0.2067	0.2067
Echinococcus multilocularis	c Jun NH2 terminal kinase	0.0546	0.6911	0.6911
Echinococcus granulosus	epidermal growth factor receptor	0.0098	0.1002	0.1002
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0067	0.0589	0.1002
Schistosoma mansoni	tyrosine kinase	0.0098	0.1002	0.1002
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0024	0.0025	0.0036
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0057	0.0457	0.0457
Brugia malayi	chloride channel protein 7	0.0025	0.0029	0.0029
Schistosoma mansoni	tyrosine kinase	0.006	0.05	0.05
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0103	0.1059	0.1059
Echinococcus multilocularis	enhancer of mRNA decapping protein 4	0.014	0.1549	0.1549
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	0.0064	0.0544	0.3173
Plasmodium vivax	cAMP-dependent protein kinase catalytic subunit, putative	0.0148	0.1653	1
Entamoeba histolytica	protein kinase, putative	0.0056	0.0447	0.2591
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0024	0.0025	0.0025
Trypanosoma brucei	5'-AMP-activated protein kinase subunit beta	0.0132	0.1451	0.2543
Schistosoma mansoni	nephrin	0.0028	0.0075	0.0075
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0148	0.1653	0.2392
Echinococcus granulosus	mitogen activated protein kinase	0.0067	0.0589	0.0589
Echinococcus multilocularis	H(+):Cl() exchange transporter 7	0.0025	0.0029	0.0029
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0148	0.1653	0.1653
Leishmania major	protein kinase A catalytic subunit isoform 1	0.0148	0.1653	0.2905
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0148	0.1653	0.1653
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0024	0.0025	0.0025
Echinococcus multilocularis	5' AMP activated protein kinase catalytic	0.0285	0.3462	0.3462
Schistosoma mansoni	serine/threonine protein kinase	0.0148	0.1653	0.1653
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0024	0.0025	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0047	0.0068
Echinococcus multilocularis	5' AMP activated protein kinase subunit gamma	0.0273	0.33	0.33
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0148	0.1653	0.2905
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 1	0.0148	0.1653	0.2905
Loa Loa (eye worm)	TK protein kinase	0.0048	0.0344	0.0498
Echinococcus multilocularis	mitogen activated protein kinase	0.0067	0.0589	0.0589
Echinococcus granulosus	NDR protein kinase	0.0024	0.0025	0.0025
Leishmania major	protein kinase A catalytic subunit isoform 2	0.0148	0.1653	0.2905
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0193	0.225	0.225
Trypanosoma cruzi	developmentally regulated phosphoprotein, putative	0.0139	0.1542	0.2707
Brugia malayi	Protein kinase domain containing protein	0.0024	0.0025	0.0025
Echinococcus multilocularis	H(+):Cl() exchange transporter 4	0.0025	0.0029	0.0029
Schistosoma mansoni	AMP-activated protein kinase gamma regulatory subunit	0.0025	0.0029	0.0029
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0064	0.0544	0.0788
Brugia malayi	hypothetical protein	0.0053	0.0398	0.0398
Trichomonas vaginalis	CAMK family protein kinase	0.006	0.0503	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0122	0.0177
Brugia malayi	Furin-like cysteine rich region family protein	0.0179	0.2067	0.2067
Giardia lamblia	5-AMP-activated protein kinase, beta-1 subunit	0.0132	0.1451	0.1426
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0067	0.0589	0.3448
Trypanosoma brucei	protein kinase, putative	0.0064	0.0544	0.0922
Echinococcus granulosus	roundabout 2	0.0032	0.0122	0.0122
Brugia malayi	Voltage gated chloride channel family protein	0.0025	0.0029	0.0029
Brugia malayi	5'-AMP-activated protein kinase, beta subunit, complex-interacting region containing protein	0.0132	0.1451	0.1451
Echinococcus granulosus	5' AMP activated protein kinase subunit beta 1	0.0071	0.0642	0.0642
Trypanosoma brucei	developmentally regulated phosphoprotein	0.0139	0.1542	0.2707
Echinococcus granulosus	H:Cl exchange transporter 3	0.0025	0.0029	0.0029
Schistosoma mansoni	hypothetical protein	0.0781	1	1
Echinococcus multilocularis	Glutaredoxin protein 5	0.0032	0.0127	0.0127
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0067	0.0589	0.1002
Chlamydia trachomatis	GutQ/KpsF family sugar-phosphate isomerase	0.0025	0.0029	0.5
Schistosoma mansoni	tyrosine kinase	0.0093	0.0929	0.0929
Brugia malayi	CLC chloride channel protein	0.0025	0.0029	0.0029
Echinococcus multilocularis	protein kinase shaggy	0.0064	0.0544	0.0544
Schistosoma mansoni	serine/threonine protein kinase	0.0546	0.6911	0.6911
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0148	0.1653	0.2905
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 2	0.0148	0.1653	0.2905
Onchocerca volvulus	Alicorn homolog	0.0116	0.123	0.1205
Schistosoma mansoni	serine/threonine protein kinase	0.0024	0.0025	0.0025
Leishmania major	hypothetical protein, conserved	0.0132	0.1451	0.2543
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0048	0.0344	0.0344
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0179	0.2067	0.2991
Loa Loa (eye worm)	TK/INSR protein kinase	0.006	0.05	0.0724
Brugia malayi	Protein kinase domain containing protein	0.0203	0.2386	0.2386
Echinococcus granulosus	AMP activated protein kinase gamma regulatory	0.0025	0.0029	0.0029
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0057	0.0457	0.0457
Onchocerca volvulus		0.0064	0.0544	0.0517
Entamoeba histolytica	PH domain containing protein kinase, putative	0.004	0.0232	0.1269
Entamoeba histolytica	protein kinase, putative	0.0056	0.0447	0.2591
Mycobacterium tuberculosis	Conserved protein	0.0781	1	1
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0449	0.562	0.562
Loa Loa (eye worm)	TK protein kinase	0.0108	0.1134	0.1641
Echinococcus granulosus	Protein kinase C brain isozyme	0.0024	0.0025	0.0025
Echinococcus multilocularis	serine:threonine kinase SAD 1	0.006	0.0503	0.0503
Trichomonas vaginalis	CMGC family protein kinase	0.0067	0.0589	0.0566
Chlamydia trachomatis	CBS domain-containing protein	0.0025	0.0029	0.5
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0065	0.0562	0.0562
Plasmodium falciparum	glycogen synthase kinase 3	0.0064	0.0544	0.3173
Echinococcus granulosus	enhancer of mRNA decapping protein 4	0.014	0.1549	0.1549
Trichomonas vaginalis	CAMK family protein kinase	0.006	0.0503	0.0479
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0064	0.0544	0.0788
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0024	0.0025	0.0036
Schistosoma mansoni	tyrosine kinase	0.0057	0.0457	0.0457
Entamoeba histolytica	protein kinase, putative	0.004	0.0228	0.1246
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0024	0.0025	0.0036
Echinococcus granulosus	5' AMP activated protein kinase subunit gamma	0.0273	0.33	0.33
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0193	0.225	0.3255
Echinococcus granulosus	Pyruvate dehydrogenase lipoamide kinase	0.0139	0.1542	0.1542
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0098	0.1002	0.1002
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0.0544	0.319
Trichomonas vaginalis	CAMK family protein kinase	0.006	0.0503	0.0479
Leishmania major	serine/threonine protein kinase, putative,protein kinase, putative	0.006	0.0503	0.0848
Leishmania major	pyruvate dehydrogenase (lipoamide) kinase, putative	0.0049	0.0347	0.057
Schistosoma mansoni	serine/threonine protein kinase	0.0024	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1542	0.2231
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0148	0.1653	0.2392
Brugia malayi	Protein kinase domain containing protein	0.006	0.05	0.05
Trichomonas vaginalis	CAMK family protein kinase	0.006	0.0503	0.0479
Giardia lamblia	Kinase, CAMK CAMKL	0.006	0.0503	0.0475
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0057	0.0457	0.0457
Trichomonas vaginalis	CMGC family protein kinase	0.0064	0.0544	0.0521
Brugia malayi	Tyrosine-protein kinase abl-1	0.0023	0.0007	0.0007
Schistosoma mansoni	tyrosine kinase	0.0179	0.2067	0.2067
Echinococcus granulosus	AMPK beta subunit	0.0132	0.1451	0.1451
Trichomonas vaginalis	CAMK family protein kinase	0.006	0.0503	0.0479
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0024	0.0025	0.0025
Loa Loa (eye worm)	IMP dehydrogenase 1	0.0025	0.0029	0.0042
Schistosoma mansoni	serine/threonine protein kinase	0.0178	0.2052	0.2052
Echinococcus granulosus	serine threonine protein kinase nrc	0.004	0.0232	0.0232
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0057	0.0457	0.0457
Trichomonas vaginalis	CAMK family protein kinase	0.006	0.0503	0.0479
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0057	0.0457	0.0457
Loa Loa (eye worm)	CAMK/CAMKL/CHK1 protein kinase	0.0203	0.2386	0.3452
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	0.0449	0.562	1
Giardia lamblia	Kinase, CMGC GSK	0.0064	0.0544	0.0517
Schistosoma mansoni	serine/threonine kinase	0.0024	0.0025	0.0025
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0148	0.1653	1
Trypanosoma cruzi	pyruvate dehydrogenase (lipoamide) kinase, putative	0.0049	0.0347	0.057
Brugia malayi	protein-tyrosine kinase	0.0048	0.0344	0.0344
Trichomonas vaginalis	AGC family protein kinase	0.0056	0.0447	0.0423
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.0139	0.1542	0.1542
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0048	0.0344	0.0344
Trichomonas vaginalis	CAMK family protein kinase	0.006	0.0503	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0398	0.0576
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 2	0.0148	0.1653	0.2905
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0024	0.0025	0.0025
Echinococcus granulosus	neuroglian	0.0028	0.0075	0.0075
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0148	0.1653	1
Echinococcus multilocularis	insulin receptor	0.006	0.05	0.05
Schistosoma mansoni	serine/threonine-protein kinase	0.004	0.0232	0.0232
Loa Loa (eye worm)	CMGC/MAPK/JNK protein kinase	0.0546	0.6911	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0057	0.0457	0.0457
Brugia malayi	ancient conserved domain protein 4	0.0025	0.0029	0.0029
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0148	0.1653	0.1653
Entamoeba histolytica	protein kinase, putative	0.0064	0.0544	0.319
Echinococcus granulosus	nervana 2	0.0032	0.0127	0.0127
Schistosoma mansoni	inosine-5-monophosphate dehydrogenase	0.0025	0.0029	0.0029
Echinococcus granulosus	mitogen activated protein kinase 14	0.0449	0.562	0.562
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0.0544	0.319
Schistosoma mansoni	serine/threonine protein kinase	0.0285	0.3462	0.3462
Schistosoma mansoni	pyruvate dehydrogenase	0.0139	0.1542	0.1542
Trichomonas vaginalis	CAMK family protein kinase	0.006	0.0503	0.0479
Brugia malayi	Protein kinase domain containing protein	0.0024	0.0025	0.0025
Giardia lamblia	Kinase, CMGC GSK	0.0064	0.0544	0.0517
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0032	0.0127	0.0127
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0023	0.0007	0.0007
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0067	0.0589	0.0852
Echinococcus granulosus	protein kinase c iota type	0.0024	0.0025	0.0025
Entamoeba histolytica	protein kinase, putative	0.0056	0.0447	0.2591
Echinococcus multilocularis	inosine 5' monophosphate dehydrogenase 2	0.0025	0.0029	0.0029
Brugia malayi	loechrig isoform VII	0.0273	0.33	0.33
Leishmania major	developmentally regulated phosphoprotein-like protein	0.0139	0.1542	0.2707
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0398	0.0576
Schistosoma mansoni	chloride channel protein	0.0025	0.0029	0.0029
Onchocerca volvulus	Tyrosine kinase homolog	0.0173	0.1984	0.196
Brugia malayi	SRC-1	0.0057	0.0457	0.0457
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0024	0.0025	0.0036
Echinococcus multilocularis	rho associated protein kinase	0.0178	0.2052	0.2052
Echinococcus granulosus	protein kinase C gamma type	0.0024	0.0025	0.0025
Giardia lamblia	Kinase, AGC PKA	0.004	0.0232	0.0203
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0056	0.0447	0.0747
Schistosoma mansoni	AMP-activated protein kinase gamma regulatory subunit	0.0025	0.0029	0.0029
Trichomonas vaginalis	AGC family protein kinase	0.0056	0.0447	0.0423
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0025	0.0036
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 1	0.0148	0.1653	0.2905
Schistosoma mansoni	tyrosine kinase	0.006	0.05	0.05
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0103	0.1059	0.1059
Echinococcus granulosus	epidermal growth factor receptor	0.0179	0.2067	0.2067
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.0139	0.1542	0.1542
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0103	0.1059	0.1059
Wolbachia endosymbiont of Brugia malayi	hemolysin	0.0025	0.0029	0.5
Trypanosoma brucei	5'-AMP-activated protein kinase catalytic subunit alpha, putative	0.006	0.0503	0.0848
Echinococcus granulosus	Glutaredoxin protein 5	0.0032	0.0127	0.0127
Trichomonas vaginalis	CMGC family protein kinase	0.0067	0.0589	0.0566
Entamoeba histolytica	serine/threonine protein kinase, putative	0.006	0.0503	0.2935
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0067	0.0589	0.1002
Echinococcus granulosus	tyrosine protein kinase HCK	0.004	0.0228	0.0228
Schistosoma mansoni	serine/threonine protein kinase	0.0024	0.0025	0.0025
Echinococcus multilocularis	tyrosine protein kinase HCK	0.004	0.0228	0.0228
Trichomonas vaginalis	CAMK family protein kinase	0.006	0.0503	0.0479
Schistosoma mansoni	tyrosine kinase	0.0057	0.0457	0.0457
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0122	0.0177
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0148	0.1653	0.1653
Trichomonas vaginalis	CMGC family protein kinase	0.0064	0.0544	0.0521
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1653	0.2392
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0449	0.562	1
Schistosoma mansoni	cell adhesion molecule	0.0026	0.0047	0.0047
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0057	0.0457	0.0457
Schistosoma mansoni	serine/threonine protein kinase	0.0148	0.1653	0.1653
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0024	0.0025	0.0025
Schistosoma mansoni	serine/threonine-protein kinase	0.004	0.0232	0.0232
Toxoplasma gondii	AGC kinase	0.0148	0.1653	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0057	0.0457	0.0457
Giardia lamblia	Kinase, AGC PKA	0.0148	0.1653	0.1629
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0449	0.562	0.562
Trichomonas vaginalis	CAMK family protein kinase	0.006	0.0503	0.0479
Trichomonas vaginalis	CMGC family protein kinase	0.0067	0.0589	0.0566
Trypanosoma cruzi	Protein kinase B	0.004	0.0232	0.0362
Loa Loa (eye worm)	hypothetical protein	0.006	0.0503	0.0727
Schistosoma mansoni	tyrosine kinase	0.0023	0.0007	0.0007
Echinococcus granulosus	serine:threonine protein kinase N2	0.0024	0.0025	0.0025
Mycobacterium ulcerans	hypothetical protein	0.0781	1	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0057	0.0457	0.0457
Trichomonas vaginalis	CAMK family protein kinase	0.006	0.0503	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0029	0.0042
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.004	0.0232	0.1247
Trichomonas vaginalis	CMGC family protein kinase	0.0067	0.0589	0.0566
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0048	0.0344	0.0344
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0026	0.0047	0.0047
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.006	0.05	0.05
Echinococcus granulosus	serine:threonine kinase SAD 1	0.006	0.0503	0.0503
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0048	0.0344	0.0344
Wolbachia endosymbiont of Brugia malayi	Mg2+/Co2+ transporter	0.0025	0.0029	0.5
Giardia lamblia	Hypothetical protein	0.0781	1	1
Trichomonas vaginalis	peptide N-glycanase, putative	0.0781	1	1
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0067	0.0589	0.1002
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0449	0.562	0.562
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.0064	0.0544	0.0544
Trichomonas vaginalis	AGC family protein kinase	0.0056	0.0447	0.0423
Echinococcus granulosus	rho-associated protein kinase 1	0.0178	0.2052	0.2052
Echinococcus multilocularis	nervana 2	0.0032	0.0127	0.0127
Brugia malayi	MAP kinase sur-1	0.0067	0.0589	0.0589
Leishmania major	protein kinase A catalytic subunit	0.0148	0.1653	0.2905
Echinococcus multilocularis	protein kinase c epsilon type	0.0024	0.0025	0.0025
Brugia malayi	ancient conserved domain protein 2	0.0025	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0029	0.0042
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0148	0.1653	0.1653
Echinococcus granulosus	twitchin	0.0036	0.018	0.018
Schistosoma mansoni	serine/threonine protein kinase	0.0024	0.0025	0.0025
Brugia malayi	5'-AMP-activated protein kinase, beta subunit, complex-interacting region containing protein	0.0132	0.1451	0.1451
Trypanosoma brucei	protein kinase A catalytic subunit, putative	0.0148	0.1653	0.2905
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0148	0.1653	0.1653
Toxoplasma gondii	AGC kinase	0.0148	0.1653	1
Toxoplasma gondii	AGC kinase	0.0056	0.0447	0.2572
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0023	0.0007	0.0007
Schistosoma mansoni	tyrosine kinase	0.0098	0.1002	0.1002
Entamoeba histolytica	PH domain containing protein kinase, putative	0.004	0.0232	0.1269
Trichomonas vaginalis	AGC family protein kinase	0.0056	0.0447	0.0423
Schistosoma mansoni	serine/threonine protein kinase	0.006	0.0503	0.0503
Echinococcus granulosus	protein kinase c epsilon type	0.0024	0.0025	0.0025
Trichomonas vaginalis	AGC family protein kinase	0.0148	0.1653	0.1633
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0108	0.1134	0.1134
Trypanosoma cruzi	glycogen synthase kinase 3, putative	0.0064	0.0544	0.0922
Brugia malayi	putative serine/threonine kinase SADA gamma	0.006	0.0503	0.0503
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0043	0.0272	0.0272
Schistosoma mansoni	atypical protein kinase C	0.0024	0.0025	0.0025
Schistosoma mansoni	protein kinase subunit beta	0.0071	0.0642	0.0642
Schistosoma mansoni	serine/threonine protein kinase	0.0024	0.0025	0.0025
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0024	0.0025	0.0025
Plasmodium vivax	serine/threonine protein kinase KIN, putative	0.006	0.0503	0.1908
Schistosoma mansoni	serine/threonine protein kinase	0.006	0.0503	0.0503
Echinococcus multilocularis	5' AMP activated protein kinase subunit beta 1	0.0071	0.0642	0.0642
Mycobacterium ulcerans	putative transglutaminase-like protein	0.0781	1	1
Schistosoma mansoni	protein kinase subunit beta	0.0132	0.1451	0.1451
Schistosoma mansoni	pyruvate dehydrogenase	0.0132	0.144	0.144
Brugia malayi	Protein kinase domain containing protein	0.0056	0.0447	0.0447
Mycobacterium tuberculosis	Long conserved protein	0.0781	1	1
Echinococcus granulosus	H:Cl exchange transporter 4	0.0025	0.0029	0.0029
Echinococcus multilocularis	5' AMP activated protein kinase subunit gamma	0.0248	0.2976	0.2976
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0148	0.1653	0.1653
Trichomonas vaginalis	AGC family protein kinase	0.0056	0.0447	0.0423
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0029	0.0042
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0057	0.0457	0.0457
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0024	0.0025	0.0025
Trichomonas vaginalis	CAMK family protein kinase	0.006	0.0503	0.0479
Echinococcus multilocularis	protein kinase c iota type	0.0024	0.0025	0.0025
Trypanosoma cruzi	5'-AMP-activated protein kinase catalytic subunit alpha, putative	0.006	0.0503	0.0848
Schistosoma mansoni	serine/threonine protein kinase	0.0024	0.0025	0.0025
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0024	0.0025	0.0036
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0781	1	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.004	0.0232	0.0232
Giardia lamblia	Kinase, CMGC MAPK	0.0067	0.0589	0.0562
Loa Loa (eye worm)	chloride channel protein 7	0.0025	0.0029	0.0042
Echinococcus granulosus	protein kinase shaggy	0.0064	0.0544	0.0544
Schistosoma mansoni	tyrosine kinase	0.0093	0.0929	0.0929
Schistosoma mansoni	serine/threonine protein kinase	0.0024	0.0025	0.0025
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0057	0.0457	0.0457
Loa Loa (eye worm)	AGC/DMPK/ROCK protein kinase	0.0537	0.6787	0.982
Trichomonas vaginalis	CAMK family protein kinase	0.006	0.0503	0.0479
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0056	0.045	0.259
Schistosoma mansoni	pyruvate dehydrogenase	0.0132	0.144	0.144
Mycobacterium leprae	Conserved hypothetical protein	0.0781	1	1
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	0.0449	0.562	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0023	0.0007	0.0007
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	0.0449	0.562	0.8132
Trichomonas vaginalis	CAMK family protein kinase	0.006	0.0503	0.0479
Giardia lamblia	Kinase, CAMK CAMKL	0.006	0.0503	0.0475
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0057	0.0457	0.0457
Echinococcus granulosus	mitogen activated protein kinase 11	0.0449	0.562	0.562
Brugia malayi	cAMP-dependent protein kinase catalytic subunit, putative	0.0148	0.1653	0.1653
Brugia malayi	kinase, mitochondrial precursor	0.0139	0.1542	0.1542
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.004	0.0232	0.0362
Echinococcus granulosus	tyrosine protein kinase Blk	0.0048	0.0344	0.0344
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0024	0.0025	0.0025
Echinococcus granulosus	Transglutaminase	0.0781	1	1
Echinococcus granulosus	mitogen activated protein kinase 3	0.0067	0.0589	0.0589
Brugia malayi	Protein kinase domain containing protein	0.0537	0.6787	0.6787
Plasmodium falciparum	serine/threonine protein kinase KIN	0.006	0.0503	0.2917
Chlamydia trachomatis	Mg++ transporter	0.0025	0.0029	0.5
Mycobacterium leprae	Conserved hypothetical protein	0.0781	1	1
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.0064	0.0544	0.0544
Mycobacterium ulcerans	transglutaminase family protein	0.0781	1	1
Loa Loa (eye worm)	5'-AMP-activated protein kinase	0.0132	0.1451	0.2099
Echinococcus multilocularis	c src tyrosine kinase	0.0023	0.0007	0.0007
Brugia malayi	p70 ribosomal S6 kinase beta	0.0056	0.0447	0.0447
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0057	0.0457	0.0457
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0067	0.0589	0.1002
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0057	0.0457	0.0457
Schistosoma mansoni	chloride channel protein	0.0025	0.0029	0.0029
Echinococcus multilocularis	neuroglian	0.0028	0.0075	0.0075
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0067	0.0589	0.1002
Echinococcus multilocularis		0.0054	0.0418	0.0418
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0024	0.0025	0.0025
Onchocerca volvulus		0.017	0.1948	0.1925
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.004	0.0232	0.0232
Trypanosoma cruzi	SNF1-related protein kinase regulatory subunit beta, putative	0.0132	0.1451	0.2543
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0103	0.1059	0.1059
Brugia malayi	EST embl\|AI107989\|AI107989 comes from the 3' UTR, putative	0.0285	0.3462	0.3462
Loa Loa (eye worm)	CAMK/CAMKL/AMPK protein kinase	0.0285	0.3462	0.501
Schistosoma mansoni	tyrosine kinase	0.0103	0.1059	0.1059
Trypanosoma brucei	protein kinase, putative	0.0067	0.0589	0.1002
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	0.0064	0.0544	0.0922
Echinococcus granulosus	5' AMP activated protein kinase catalytic	0.0285	0.3462	0.3462
Trypanosoma brucei	pyruvate dehydrogenase (lipoamide) kinase, putative	0.0049	0.0347	0.057
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.006	0.05	0.05
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0024	0.0025	0.0025
Schistosoma mansoni	serine/threonine protein kinase	0.0148	0.1653	0.1653
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0057	0.0457	0.0457
Brugia malayi	inosine-5'-monophosphate dehydrogenase family protein	0.0025	0.0029	0.0029
Echinococcus granulosus	c-Jun N-terminal kinases	0.0546	0.6911	0.6911
Brugia malayi	P38 map kinase family protein 2	0.0449	0.562	0.562
Echinococcus multilocularis	Transglutaminase	0.0781	1	1
Echinococcus granulosus	H:Cl exchange transporter 7	0.0025	0.0029	0.0029
Echinococcus granulosus	inosine 5' monophosphate dehydrogenase 2	0.0025	0.0029	0.0029
Echinococcus multilocularis	nervana 2	0.0032	0.0127	0.0127
Echinococcus multilocularis	SNF4:AMP activated protein kinase gamma subunit	0.0025	0.0029	0.0029
Echinococcus multilocularis	epidermal growth factor receptor	0.0098	0.1002	0.1002
Loa Loa (eye worm)	CAMK/CAMKL/BRSK protein kinase	0.006	0.0503	0.0727
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.0064	0.0544	0.0544
Schistosoma mansoni	serine/threonine protein kinase	0.006	0.0503	0.0503
Giardia lamblia	5-AMP-activated protein kinase, gamma-1 subunit	0.0273	0.33	0.328
Schistosoma mansoni	protein kinase subunit gamma	0.0273	0.33	0.33
Echinococcus granulosus	tyrosine kinase	0.0048	0.0344	0.0344
Brugia malayi	Stress-activated protein kinase jnk-1	0.0546	0.6911	0.6911
Schistosoma mansoni	serine/threonine protein kinase	0.006	0.0503	0.0503
Brugia malayi	CBS domain containing protein	0.0025	0.0029	0.0029
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0043	0.0272	0.0272
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0023	0.0007	0.0007
Mycobacterium tuberculosis	Hypothetical protein	0.0781	1	1
Wolbachia endosymbiont of Brugia malayi	Mg/Co/Ni transporter MgtE	0.0025	0.0029	0.5
Wolbachia endosymbiont of Brugia malayi	IMP dehydrogenase	0.0025	0.0029	0.5
Entamoeba histolytica	protein kinase 2, putative	0.004	0.0232	0.1269
Schistosoma mansoni	serine/threonine protein kinase	0.0067	0.0589	0.0589
Echinococcus multilocularis	rac serine:threonine kinase	0.004	0.0232	0.0232
Loa Loa (eye worm)	chloride channel 3	0.0025	0.0029	0.0042
Trypanosoma cruzi	5'-AMP-activated protein kinase subunit beta, putative	0.0132	0.1451	0.2543
Trichomonas vaginalis	CAMK family protein kinase	0.006	0.0503	0.0479
Echinococcus granulosus	nervana 2	0.0032	0.0127	0.0127
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0067	0.0589	0.0589
Brugia malayi	intracellular kinase	0.0064	0.0544	0.0544
Onchocerca volvulus		0.0162	0.1836	0.1812
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0032	0.0127	0.0127
Echinococcus granulosus	insulin receptor	0.006	0.05	0.05
Onchocerca volvulus		0.0178	0.2052	0.2029
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0057	0.0457	0.0457
Loa Loa (eye worm)	loechrig isoform VII	0.0273	0.33	0.4775
Plasmodium falciparum	cAMP-dependent protein kinase catalytic subunit	0.0148	0.1653	1

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (binding)	= 6.11	SUPPLEMENTARY: Inhibition of P-glycoprotein expressed in MDR CCRF vcr1000 cells by daunorubicin efflux assay. Same assay as CHEMBL914418	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2449322

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1809633