TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 464.563 | Formula: C24H32N8O2
H donors: 2 H acceptors: 6 LogP: 3.93 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CC(CN1CCC(CC1)n1nnnc1CCCCOc1ccc2c(c1)cc1c([nH]2)nc(n1)O)C
InChi: 1S/C24H32N8O2/c1-16(2)15-31-10-8-18(9-11-31)32-22(28-29-30-32)5-3-4-12-34-19-6-7-20-17(13-19)14-21-23(25-20)27-24(33)26-21/h6-7,13-14,16,18H,3-5,8-12,15H2,1-2H3,(H2,25,26,27,33)
InChiKey: HBQKKFACQRPHGJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.011	0.0603	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0616	0.3564	1
Loa Loa (eye worm)	DR-78	0.029	0.1659	0.1659
Loa Loa (eye worm)	hypothetical protein	0.0616	0.3564	0.3564
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.029	0.1659	0.2479
Loa Loa (eye worm)	RecQ helicase	0.0014	0.004	0.004
Loa Loa (eye worm)	hypothetical protein	0.029	0.1659	0.1659
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	0.0264	0.1508	0.1492
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.029	0.1659	0.2479
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0027	0.0119	0.0161
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.1144	0.6655	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0011	0.0011
Schistosoma mansoni	nuclear hormone receptor	0.0616	0.3564	1
Echinococcus multilocularis	survival motor neuron protein 1	0.0168	0.094	0.1396
Schistosoma mansoni	zinc finger protein	0.029	0.1659	0.4656
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0021	0.0081	0.0226
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0035	0.0166	0.0465
Loa Loa (eye worm)	hypothetical protein	0.0325	0.1863	0.1863
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.011	0.0603	0.5
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0021	0.0081	0.0226
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.011	0.0603	0.4705
Mycobacterium tuberculosis	Probable lipase LipD	0.0053	0.0271	0.0483
Loa Loa (eye worm)	glutamate receptor	0.0292	0.1668	0.1668
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0616	0.3564	0.5347
Brugia malayi	hypothetical protein	0.0325	0.1863	0.1848
Loa Loa (eye worm)	latrophilin receptor protein 2	0.003	0.0132	0.0132
Echinococcus multilocularis	muscleblind protein	0.0412	0.237	0.3548
Loa Loa (eye worm)	hypothetical protein	0.0168	0.094	0.094
Brugia malayi	hypothetical protein	0.0325	0.1863	0.1848
Schistosoma mansoni	glutamate receptor NMDA	0.0027	0.0119	0.0335
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.011	0.0603	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0616	0.3564	0.4394
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0616	0.3564	0.3552
Echinococcus granulosus	muscleblind protein	0.0412	0.237	0.2916
Brugia malayi	jmjC domain containing protein	0.0011	0.0024	0.0005
Loa Loa (eye worm)	TAR-binding protein	0.0055	0.0284	0.0284
Plasmodium vivax	SET domain protein, putative	0.0021	0.0081	0.1339
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0014	0.004	0.0033
Echinococcus multilocularis	GPCR, family 2	0.003	0.0132	0.018
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0119	0.0119
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.001	0.0019	0.0019
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0014	0.004	0.0643
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.029	0.1659	0.4548
Schistosoma mansoni	jumonji domain containing protein	0.0042	0.0203	0.0569
Echinococcus granulosus	glutamate receptor 2	0.0027	0.0119	0.0132
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.029	0.1659	0.4656
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0019	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0119	0.0119
Brugia malayi	hypothetical protein	0.029	0.1659	0.1644
Echinococcus granulosus	lamin	0.0019	0.0071	0.0072
Toxoplasma gondii	ABC1 family protein	0.0053	0.0271	0.4496
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0027	0.0119	0.0132
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0035	0.0166	0.0465
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0616	0.3564	0.3564
Loa Loa (eye worm)	hypothetical protein	0.0325	0.1863	0.1863
Treponema pallidum	fructose-bisphosphate aldolase	0.0226	0.1281	1
Onchocerca volvulus	Bile acid receptor homolog	0.0616	0.3564	1
Schistosoma mansoni	nuclear hormone receptor	0.029	0.1659	0.4656
Schistosoma mansoni	hypothetical protein	0.003	0.0132	0.0372
Schistosoma mansoni	nuclear receptor	0.029	0.1659	0.4656
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0042	0.0203	0.0569
Brugia malayi	Nuclear hormone receptor-like 1	0.0325	0.1863	0.1848
Echinococcus granulosus	lamin dm0	0.0019	0.0071	0.0072
Echinococcus multilocularis	lysine specific demethylase 6a	0.0011	0.0024	0.0017
Echinococcus granulosus	survival motor neuron protein 1	0.0168	0.094	0.1147
Schistosoma mansoni	intermediate filament proteins	0.0019	0.0071	0.0198
Echinococcus granulosus	jumonji domain containing 1A	0.0011	0.0024	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0616	0.3564	0.3564
Schistosoma mansoni	DNA helicase recq1	0.0014	0.004	0.0111
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.004	0.019	0.0118
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0616	0.3564	0.4394
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0226	0.1281	1
Echinococcus granulosus	nmda type glutamate receptor	0.0027	0.0119	0.0132
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0616	0.3564	0.3552
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0226	0.1281	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0119	0.0119
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.003	0.0132	0.018
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0027	0.0119	0.0161
Loa Loa (eye worm)	hypothetical protein	0.011	0.0603	0.0603
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0616	0.3564	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0011	0.0011
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0027	0.0119	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0616	0.3564	0.3564
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0226	0.1281	1
Brugia malayi	nuclear receptor RXR	0.0325	0.1863	0.1848
Echinococcus multilocularis	lamin	0.0019	0.0071	0.0087
Loa Loa (eye worm)	hypothetical protein	0.003	0.0132	0.0132
Loa Loa (eye worm)	MH2 domain-containing protein	0.0076	0.0405	0.0405
Brugia malayi	ecdysone receptor	0.029	0.1659	0.1644
Loa Loa (eye worm)	hypothetical protein	0.0325	0.1863	0.1863
Trypanosoma cruzi	hypothetical protein, conserved	0.0053	0.0271	1
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.011	0.0603	0.9955
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.011	0.0604	1
Echinococcus granulosus	glutamate receptor 2	0.0027	0.0119	0.0132
Brugia malayi	Intermediate filament tail domain containing protein	0.0019	0.0071	0.0052
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0053	0.0271	0.0253
Brugia malayi	Probable ClpP-like protease	0.011	0.0603	0.0585
Trypanosoma cruzi	hypothetical protein, conserved	0.0053	0.0271	1
Brugia malayi	Latrophilin receptor protein 2	0.003	0.0132	0.0114
Echinococcus multilocularis	musashi	0.0019	0.0071	0.0087
Loa Loa (eye worm)	jmjC domain-containing protein	0.0011	0.0024	0.0024
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0616	0.3564	0.3552
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0226	0.1281	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0616	0.3564	1
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0053	0.0271	0.0483
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0616	0.3564	0.3552
Schistosoma mansoni	tyrosine kinase	0.0027	0.0119	0.0335
Mycobacterium tuberculosis	Probable esterase LipL	0.0053	0.0271	0.0483
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0616	0.3564	0.3552
Brugia malayi	RNA binding protein	0.0055	0.0284	0.0265
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0014	0.004	0.0659
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.029	0.1659	0.2479
Echinococcus granulosus	bloom syndrome protein	0.0014	0.004	0.0033
Mycobacterium tuberculosis	Conserved protein	0.0053	0.0271	0.0483
Schistosoma mansoni	hypothetical protein	0.0118	0.0651	0.1826
Brugia malayi	Nuclear hormone receptor-like 1	0.0325	0.1863	0.1848
Echinococcus granulosus	Nuclear hormone receptor HR96	0.029	0.1659	0.2037
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0035	0.0166	0.0465
Mycobacterium tuberculosis	Probable hydrolase	0.0053	0.0271	0.0483
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.029	0.1659	0.4656
Brugia malayi	RNA recognition motif domain containing protein	0.0055	0.0284	0.0265
Echinococcus multilocularis	phd:f box containing protein	0.0011	0.0024	0.0017
Loa Loa (eye worm)	hypothetical protein	0.029	0.1659	0.1659
Mycobacterium tuberculosis	Probable lipase LipE	0.0053	0.0271	0.0483
Loa Loa (eye worm)	hypothetical protein	0.0616	0.3564	0.3564
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0053	0.0271	0.0483
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0034	0.0159	0.014
Loa Loa (eye worm)	hypothetical protein	0.029	0.1659	0.1659
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0325	0.1863	0.5228
Schistosoma mansoni	metabotropic glutamate receptor	0.0142	0.0792	0.2222
Echinococcus granulosus	receptor type guanylyl cyclase	0.0027	0.0119	0.0132
Loa Loa (eye worm)	hypothetical protein	0.029	0.1659	0.1659
Brugia malayi	Pre-SET motif family protein	0.0145	0.0809	0.0792
Brugia malayi	Nuclear hormone receptor E75	0.029	0.1659	0.1644
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.029	0.1659	0.1644
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0271	0.0271
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0616	0.3564	0.3564
Onchocerca volvulus		0.0616	0.3564	1
Brugia malayi	ecdysteroid receptor	0.0616	0.3564	0.3552
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0271	0.0271
Brugia malayi	jmjC domain containing protein	0.0042	0.0203	0.0184
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0035	0.0166	0.0147
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.004	0.019	0.0268
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0616	0.3564	0.3552
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0011	0.0024	0.0014
Mycobacterium leprae	Probable lipase LipE	0.0053	0.0271	0.2132
Schistosoma mansoni	metabotropic glutamate receptor	0.0245	0.1391	0.3902
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0616	0.3564	1
Schistosoma mansoni	coup transcription factor	0.0616	0.3564	1
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.011	0.0604	1
Toxoplasma gondii	hypothetical protein	0.0038	0.0181	0.2996
Echinococcus multilocularis	lysine specific demethylase 5A	0.0042	0.0203	0.0286
Loa Loa (eye worm)	hypothetical protein	0.029	0.1659	0.1659
Echinococcus granulosus	neuropeptide s receptor	0.0329	0.1887	0.2319
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0616	0.3564	1
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.002	0.0076	0.0079
Schistosoma mansoni	tar DNA-binding protein	0.0055	0.0284	0.0796
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0616	0.3564	0.3552
Loa Loa (eye worm)	beta-lactamase	0.0053	0.0271	0.0271
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.004	0.019	0.0534
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0119	0.0119
Echinococcus granulosus	lysine specific demethylase 5A	0.0042	0.0203	0.0235
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0042	0.0203	0.0286
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0035	0.0166	0.023
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0072	0.0381	0.0554
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0039	0.0186	0.0214
Schistosoma mansoni	phosphatidylserine receptor	0.0011	0.0024	0.0067
Brugia malayi	Nuclear hormone receptor-like 1	0.0616	0.3564	0.3552
Onchocerca volvulus		0.0027	0.0119	0.014
Echinococcus multilocularis	nmda type glutamate receptor	0.0027	0.0119	0.0161
Loa Loa (eye worm)	nuclear receptor NHR-67	0.029	0.1659	0.1659
Schistosoma mansoni	tar DNA-binding protein	0.0055	0.0284	0.0796
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0042	0.0203	0.0569
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0055	0.0284	0.0284
Loa Loa (eye worm)	hypothetical protein	0.029	0.1659	0.1659
Loa Loa (eye worm)	hypothetical protein	0.0616	0.3564	0.3564
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.004	0.019	0.0028
Loa Loa (eye worm)	steroid hormone receptor	0.1715	1	1
Loa Loa (eye worm)	hypothetical protein	0.0325	0.1863	0.1863
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0053	0.0271	0.0271
Brugia malayi	Nuclear hormone receptor E75	0.029	0.1659	0.1644
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.004	0.019	0.0172
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0042	0.0203	0.0235
Echinococcus multilocularis	bloom syndrome protein	0.0014	0.004	0.0041
Onchocerca volvulus	Metabotropic glutamate receptor homolog	0.0047	0.0236	0.0474
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.004	0.019	0.6744
Brugia malayi	jmjC domain containing protein	0.0011	0.0024	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0119	0.0119
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.004	0.019	0.022
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0053	0.0271	0.076
Schistosoma mansoni	DNA helicase recq5	0.0014	0.004	0.0111
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0014	0.004	0.0643
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0616	0.3564	1
Brugia malayi	Receptor family ligand binding region containing protein	0.0075	0.0397	0.0379
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0021	0.0081	0.0102
Entamoeba histolytica	recQ family helicase, putative	0.0014	0.004	0.031
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0271	0.0271
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.011	0.0604	0.237
Brugia malayi	photoreceptor-specific nuclear receptor	0.0616	0.3564	0.3552
Brugia malayi	nuclear receptor NHR-88	0.029	0.1659	0.1644
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0616	0.3564	0.3564
Onchocerca volvulus		0.0053	0.0271	0.0573
Schistosoma mansoni	hypothetical protein	0.003	0.0132	0.0372
Brugia malayi	orphan nuclear receptor NR2E1	0.029	0.1659	0.1644
Loa Loa (eye worm)	hypothetical protein	0.0325	0.1863	0.1863
Mycobacterium tuberculosis	Conserved protein	0.0053	0.0271	0.0483
Mycobacterium ulcerans	beta-lactamase	0.0053	0.0271	0.2038
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.011	0.0603	0.9955
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0226	0.1281	1
Entamoeba histolytica	hypothetical protein	0.0027	0.0119	0.0933
Schistosoma mansoni	phd/f-box containing protein	0.0011	0.0024	0.0067
Echinococcus multilocularis	neuropeptide receptor A26	0.0329	0.1887	0.2822
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0014	0.004	0.004
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0027	0.0119	0.0119
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0226	0.1281	1
Brugia malayi	Steroid receptor seven-up type 2	0.0616	0.3564	0.3552
Loa Loa (eye worm)	hypothetical protein	0.0616	0.3564	0.3564
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.029	0.1659	0.1659
Schistosoma mansoni	lamin	0.0019	0.0071	0.0198
Loa Loa (eye worm)	metabotropic GABA-B receptor subtype 2	0.0075	0.0397	0.0397
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0039	0.0186	0.6544
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0013	0.0013
Schistosoma mansoni	thyroid hormone receptor	0.0616	0.3564	1
Brugia malayi	jmjC domain containing protein	0.0011	0.0024	0.0005
Echinococcus multilocularis	ecdysone induced protein 78C	0.0616	0.3564	0.5347
Onchocerca volvulus	Protein ultraspiracle homolog	0.0616	0.3564	1
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.0014	0.004	0.0275
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0072	0.0381	0.1104
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0069	0.0069
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0325	0.1863	0.5228
Plasmodium vivax	hypothetical protein, conserved	0.0053	0.0271	0.4496
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0014	0.004	0.0275
Loa Loa (eye worm)	jmjC domain-containing protein	0.0011	0.0024	0.0024
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0038	0.0181	0.141
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0616	0.3564	0.5347
Echinococcus multilocularis	lamin dm0	0.0019	0.0071	0.0087
Loa Loa (eye worm)	glutamate receptor	0.0115	0.0631	0.0631
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0027	0.0119	0.0161
Echinococcus granulosus	GPCR family 3 C terminal	0.0047	0.0236	0.0277
Brugia malayi	metabotropic glutamate receptor type 2	0.0142	0.0792	0.0775
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0616	0.3564	0.5347
Trichomonas vaginalis	D-aminoacylase, putative	0.0053	0.0271	0.1863
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0616	0.3564	1
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0334	0.0334
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0616	0.3564	0.3564
Echinococcus multilocularis	geminin	0.0118	0.0651	0.0961
Brugia malayi	TAR-binding protein	0.0055	0.0284	0.0265
Echinococcus granulosus	histone lysine methyltransferase setb	0.0021	0.0081	0.0084
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.0075	0.0397	0.0397
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0145	0.0809	0.0809
Onchocerca volvulus		0.0053	0.0271	0.0573
Echinococcus granulosus	peptidase Clp S14 family	0.0072	0.0381	0.0455
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0325	0.1863	0.2786
Echinococcus multilocularis	glutamate receptor 2	0.0027	0.0119	0.0161
Brugia malayi	metabotropic GABA-B receptor subtype 2	0.0027	0.0119	0.0101
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0616	0.3564	0.3564
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0292	0.1668	0.1653
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.011	0.0603	0.5
Echinococcus granulosus	ecdysone induced protein 78C	0.0616	0.3564	0.4394
Loa Loa (eye worm)	hypothetical protein	0.029	0.1659	0.1659
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.003	0.0132	0.0114
Brugia malayi	Muscleblind-like protein	0.0412	0.237	0.2355
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0011	0.0024	0.0395
Echinococcus granulosus	tar DNA binding protein	0.0055	0.0284	0.0335
Trichomonas vaginalis	D-aminoacylase, putative	0.0053	0.0271	0.1863
Brugia malayi	jmjC domain containing protein	0.0011	0.0024	0.0005
Mycobacterium ulcerans	lipase LipD	0.0053	0.0271	0.2038
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0021	0.0081	0.0102
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0035	0.0166	0.0166
Brugia malayi	jmjC domain containing protein	0.0042	0.0203	0.0184
Loa Loa (eye worm)	hypothetical protein	0.029	0.1659	0.1659
Schistosoma mansoni	hypothetical protein	0.0118	0.0651	0.1826
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0053	0.0271	0.2038
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0038	0.0181	0.2996
Loa Loa (eye worm)	hypothetical protein	0.029	0.1659	0.1659
Echinococcus granulosus	lysine specific demethylase 6a	0.0011	0.0024	0.0014
Schistosoma mansoni	protein kinase	0.0027	0.0119	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0024	0.0024
Echinococcus granulosus	beta LACTamase domain containing family member	0.0053	0.0271	0.0319
Loa Loa (eye worm)	hypothetical protein	0.0412	0.237	0.237
Echinococcus granulosus	phd:f box containing protein	0.0011	0.0024	0.0014
Echinococcus multilocularis	atrial natriuretic peptide receptor	0.0027	0.0119	0.0161
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0616	0.3564	0.3552
Echinococcus granulosus	JmjC domain containing protein 4	0.0011	0.0024	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0397	0.0397
Echinococcus granulosus	geminin	0.0118	0.0651	0.079
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0616	0.3564	0.4394
Echinococcus multilocularis	jumonji domain containing 1A	0.0011	0.0024	0.0017
Brugia malayi	hypothetical protein	0.0168	0.094	0.0923
Schistosoma mansoni	RAR-like nuclear receptor	0.0616	0.3564	1
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.011	0.0603	0.073
Brugia malayi	intermediate filament protein	0.0019	0.0071	0.0052
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0038	0.0181	0.2708
Loa Loa (eye worm)	hypothetical protein	0.029	0.1659	0.1659
Mycobacterium ulcerans	hypothetical protein	0.0053	0.0271	0.2038
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0616	0.3564	1
Brugia malayi	hypothetical protein	0.029	0.1659	0.1644
Schistosoma mansoni	tyrosine kinase	0.0027	0.0119	0.0335
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.003	0.0132	0.018
Mycobacterium leprae	conserved hypothetical protein	0.0053	0.0271	0.2132
Echinococcus multilocularis	FTZ F1 alpha	0.0616	0.3564	0.5347
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.029	0.1659	0.2037
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0035	0.0166	0.0189
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0014	0.004	0.0021
Trichomonas vaginalis	esterase, putative	0.0053	0.0271	0.1863
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.004	0.019	0.0118
Schistosoma mansoni	nuclear receptor nhr-48	0.029	0.1659	0.4656
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0226	0.1281	1
Echinococcus granulosus	FTZ F1 alpha	0.0616	0.3564	0.4394
Schistosoma mansoni	protein phosphatase 2C	0.0011	0.0024	0.0067
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0035	0.0166	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0119	0.0119
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0616	0.3564	0.5347
Echinococcus granulosus	atrial natriuretic peptide receptor	0.0027	0.0119	0.0132
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0094	0.0508	0.049
Schistosoma mansoni	peptidase Clp (S14 family)	0.011	0.0603	0.1691
Loa Loa (eye worm)	hypothetical protein	0.029	0.1659	0.1659
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.011	0.0603	0.0888
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.011	0.0603	0.9955
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0027	0.0119	0.0119
Giardia lamblia	Fructose-bisphosphate aldolase	0.0226	0.1281	1
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0072	0.0381	0.1104
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0616	0.3564	0.3564
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0616	0.3564	0.4394
Loa Loa (eye worm)	nuclear hormone receptor	0.029	0.1659	0.1659
Onchocerca volvulus		0.0021	0.0081	0.0029
Onchocerca volvulus		0.0165	0.0926	0.245
Onchocerca volvulus		0.0027	0.0119	0.014
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0508	0.0508
Brugia malayi	MH2 domain containing protein	0.0076	0.0405	0.0387
Echinococcus granulosus	tyrosine kinase	0.0027	0.0119	0.0132
Loa Loa (eye worm)	metabotropic glutamate receptor 8	0.0027	0.0119	0.0119
Onchocerca volvulus		0.0053	0.0271	0.0573
Schistosoma mansoni	hypothetical protein	0.003	0.0132	0.0372
Brugia malayi	beta-lactamase	0.0053	0.0271	0.0253
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0027	0.0119	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0014	0.004	0.004
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0021	0.0081	0.1339
Schistosoma mansoni	tar DNA-binding protein	0.0055	0.0284	0.0796
Brugia malayi	metabotropic GABA-B receptor subtype 2	0.0047	0.0236	0.0218
Plasmodium vivax	JmjC domain containing protein	0.0011	0.0024	0.0395
Onchocerca volvulus		0.029	0.1659	0.4548
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0027	0.0119	0.0161
Brugia malayi	beta-lactamase family protein	0.0053	0.0271	0.0253
Schistosoma mansoni	nuclear receptor	0.029	0.1659	0.4656
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0616	0.3564	0.5347
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0027	0.0119	0.0119
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0014	0.004	0.0041
Schistosoma mansoni	aldehyde dehydrogenase	0.0039	0.0186	0.0521
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0014	0.004	0.0643
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0332	0.1903	0.5338
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0021	0.0081	0.0226
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0011	0.0024	0.0067
Brugia malayi	nuclear receptor NHR-67	0.029	0.1659	0.1644
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0341	0.1953	1
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0014	0.004	0.0021
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0027	0.0119	0.0132
Echinococcus granulosus	neuropeptide receptor A26	0.0329	0.1887	0.2319
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0325	0.1863	0.229
Echinococcus multilocularis	tyrosine kinase	0.0027	0.0119	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0616	0.3564	0.3564
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0616	0.3564	0.3552
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0249	0.1416	0.1416
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0245	0.1391	0.1705
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.029	0.1659	0.2479
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0024	0.0024
Schistosoma mansoni	jumonji domain containing protein	0.0011	0.0024	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0081	0.0081
Brugia malayi	Pre-SET motif family protein	0.0021	0.0081	0.0062
Schistosoma mansoni	thyroid hormone receptor	0.0616	0.3564	1
Brugia malayi	conserved hypotetical protein	0.029	0.1659	0.1644
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.029	0.1659	0.2479
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0271	0.0271
Loa Loa (eye worm)	jmjC domain-containing protein	0.0042	0.0203	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0616	0.3564	0.3564
Schistosoma mansoni	tar DNA-binding protein	0.0055	0.0284	0.0796
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0271	0.0271
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0011	0.0024	0.0395
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0616	0.3564	0.4394
Brugia malayi	nuclear hormone receptor family member odr-7	0.029	0.1659	0.1644
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0359	0.2063	0.3087
Schistosoma mansoni	hypothetical protein	0.0047	0.0236	0.0663
Onchocerca volvulus	Poor gastrulation protein homolog	0.0047	0.0236	0.0474
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0616	0.3564	0.4394
Schistosoma mansoni	hypothetical protein	0.003	0.0132	0.0372
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0245	0.1391	0.2075
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0035	0.0166	0.023
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0226	0.1281	1
Onchocerca volvulus		0.029	0.1659	0.4548
Leishmania major	extracellular receptor, putative	0.0027	0.0119	0.3872
Leishmania major	hypothetical protein, conserved	0.0053	0.0271	1
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0325	0.1863	0.1863
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0027	0.0119	0.014
Echinococcus multilocularis	GPCR, family 3, C terminal	0.0047	0.0236	0.0336
Brugia malayi	tailless protein	0.029	0.1659	0.1644
Echinococcus granulosus	Nuclear hormone receptor HR96	0.029	0.1659	0.2037
Echinococcus granulosus	GPCR family 2	0.003	0.0132	0.0148
Brugia malayi	Guanylyl cyclase protein 23	0.0027	0.0119	0.0101
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0616	0.3564	0.5347
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0034	0.0159	0.0159
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0616	0.3564	0.3564
Loa Loa (eye worm)	jmjC domain-containing protein	0.0011	0.0024	0.0024
Brugia malayi	Receptor family ligand binding region containing protein	0.0027	0.0119	0.0101
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0616	0.3564	1
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0014	0.004	0.0033
Brugia malayi	latrophilin 2 splice variant baaae	0.0064	0.0334	0.0316
Schistosoma mansoni	tar DNA-binding protein	0.0055	0.0284	0.0796
Loa Loa (eye worm)	hypothetical protein	0.0412	0.237	0.237
Echinococcus granulosus	nuclear receptor nhr 48	0.029	0.1659	0.2037
Loa Loa (eye worm)	hypothetical protein	0.029	0.1659	0.1659
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0616	0.3564	0.5347
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0014	0.004	0.0041
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0011	0.0024	0.0017
Schistosoma mansoni	nuclear hormone receptor	0.029	0.1659	0.4656
Mycobacterium tuberculosis	Conserved protein	0.0053	0.0271	0.0483
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0616	0.3564	0.3552
Schistosoma mansoni	lamin	0.0019	0.0071	0.0198
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0359	0.2063	0.2537
Trichomonas vaginalis	set domain proteins, putative	0.0165	0.0926	0.7145
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0616	0.3564	0.3552
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0053	0.0271	0.076
Trypanosoma cruzi	extracellular receptor, putative	0.0027	0.0119	0.3872
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0119	0.0119
Trichomonas vaginalis	D-aminoacylase, putative	0.0053	0.0271	0.1863
Brugia malayi	nuclear hormone receptor family member nhr-6	0.029	0.1659	0.1644
Loa Loa (eye worm)	RNA binding protein	0.0055	0.0284	0.0284
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0094	0.0508	0.049
Mycobacterium ulcerans	esterase/lipase LipP	0.0053	0.0271	0.2038
Trypanosoma brucei	hypothetical protein, conserved	0.0053	0.0271	1
Echinococcus multilocularis	neuropeptide s receptor	0.0329	0.1887	0.2822
Onchocerca volvulus		0.0034	0.0159	0.0253
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0053	0.0271	0.0389
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0616	0.3564	0.3552
Echinococcus multilocularis	nuclear receptor nhr 48	0.029	0.1659	0.2479
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.003	0.0132	0.0148
Brugia malayi	nuclear receptor NHR-88	0.0616	0.3564	0.3552
Schistosoma mansoni	hypothetical protein	0.0034	0.0159	0.0446
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0021	0.0081	0.0226
Brugia malayi	beta-lactamase family protein	0.0053	0.0271	0.0253
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0072	0.0381	0.4723
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0226	0.1281	1
Echinococcus granulosus	thyroid hormone receptor alpha	0.1389	0.8095	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0071	0.0071
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0039	0.0186	0.026
Trichomonas vaginalis	penicillin-binding protein, putative	0.0053	0.0271	0.1863
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.003	0.0132	0.0148
Echinococcus multilocularis	JmjC domain containing protein 4	0.0011	0.0024	0.0017
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.029	0.1659	0.2037
Echinococcus granulosus	intermediate filament protein	0.0019	0.0071	0.0072
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0616	0.3564	0.4394
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0014	0.004	0.0659
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0053	0.0271	0.0483
Schistosoma mansoni	survival motor neuron protein	0.0034	0.0159	0.0446
Schistosoma mansoni	aldehyde dehydrogenase	0.0039	0.0186	0.0521
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.029	0.1659	0.4548
Schistosoma mansoni	hypothetical protein	0.0064	0.0334	0.0937
Echinococcus multilocularis	muscleblind protein 1	0.0412	0.237	0.3548
Echinococcus multilocularis	glutamate receptor 2	0.0027	0.0119	0.0161
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.011	0.0603	0.5
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0027	0.0119	0.0132
Loa Loa (eye worm)	intermediate filament protein	0.0019	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0359	0.2063	0.2063
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0024	0.0024
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0094	0.0508	0.0508
Echinococcus multilocularis	tar DNA binding protein	0.0055	0.0284	0.0408
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.011	0.0603	1
Loa Loa (eye worm)	hypothetical protein	0.029	0.1659	0.1659
Brugia malayi	nuclear receptor RXR	0.029	0.1659	0.1644
Loa Loa (eye worm)	transcription factor SMAD2	0.0076	0.0405	0.0405
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.011	0.0603	1
Brugia malayi	nuclear hormone receptor	0.0616	0.3564	0.3552
Brugia malayi	Bloom's syndrome protein homolog	0.0014	0.004	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0271	0.0271
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0226	0.1281	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0053	0.0271	0.1863
Toxoplasma gondii	aldehyde dehydrogenase	0.0039	0.0186	0.3079
Brugia malayi	follicle stimulating hormone receptor	0.0249	0.1416	0.14
Brugia malayi	hypothetical protein	0.0027	0.0119	0.0101
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0616	0.3564	0.3552
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0236	0.0236
Brugia malayi	nuclear hormone receptor	0.029	0.1659	0.1644

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 0.009 nM	Inhibition of human platelet aggregation induced by ADP after 3 min incubation with platelet rich plasma	ChEMBL.	8230115
S	> 10 mg ml-1	Aqueous solubility	ChEMBL.	8230115

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 181485