Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dopamine transporter | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Fxna peptidase homolog | 0.0431 | 0.1237 | 0.1237 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0431 | 0.1237 | 0.5 |
Brugia malayi | leucyl aminopeptidase | 0.0431 | 0.1237 | 0.1237 |
Mycobacterium ulcerans | hypothetical protein | 0.0431 | 0.1237 | 0.5 |
Brugia malayi | FXNA | 0.0431 | 0.1237 | 0.1237 |
Loa Loa (eye worm) | hypothetical protein | 0.0431 | 0.1237 | 0.1237 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0431 | 0.1237 | 0.1237 |
Toxoplasma gondii | hypothetical protein | 0.0431 | 0.1237 | 0.5 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0431 | 0.1237 | 0.1237 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0431 | 0.1237 | 0.5 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0431 | 0.1237 | 0.1237 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0431 | 0.1237 | 0.5 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0431 | 0.1237 | 0.1237 |
Leishmania major | hypothetical protein, conserved | 0.0431 | 0.1237 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0431 | 0.1237 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0431 | 0.1237 | 0.5 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0431 | 0.1237 | 0.5 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0431 | 0.1237 | 0.1237 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0431 | 0.1237 | 0.1237 |
Schistosoma mansoni | nicalin (M28 family) | 0.0431 | 0.1237 | 0.1237 |
Loa Loa (eye worm) | hypothetical protein | 0.2706 | 1 | 1 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0431 | 0.1237 | 0.1237 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.2706 | 1 | 1 |
Brugia malayi | nicalin | 0.0431 | 0.1237 | 0.1237 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0431 | 0.1237 | 0.1237 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0431 | 0.1237 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0431 | 0.1237 | 0.5 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0109 | 0 | 0.5 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0431 | 0.1237 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0431 | 0.1237 | 0.5 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0431 | 0.1237 | 0.1237 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.2706 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0431 | 0.1237 | 0.1237 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.2706 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0431 | 0.1237 | 0.1237 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.2706 | 1 | 1 |
Onchocerca volvulus | 0.0431 | 0.1237 | 0.1237 | |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0431 | 0.1237 | 0.5 |
Leishmania major | glutaminyl cyclase, putative | 0.0431 | 0.1237 | 0.5 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0431 | 0.1237 | 0.1237 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0431 | 0.1237 | 0.1237 |
Loa Loa (eye worm) | hypothetical protein | 0.0431 | 0.1237 | 0.1237 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 238 nM | Displacement of [3H]WIN35,428 from Sprague-Dawley rat brain DAT after 120 mins by liquid scintillation counting analysis | ChEMBL. | 24494745 |
Ki (binding) | = 60700 nM | Displacement of [3H]citalopram from Sprague-Dawley rat brain SERT after 60 mins by liquid scintillation counting analysis | ChEMBL. | 24494745 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.