TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 360.476 | Formula: C19H24O5Si
H donors: 1 H acceptors: 1 LogP: 4.7 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(cc(c1OC)OC)[Si]1(CCC1)c1ccc(c(c1)O)OC
InChi: 1S/C19H24O5Si/c1-21-16-7-6-13(10-15(16)20)25(8-5-9-25)14-11-17(22-2)19(24-4)18(12-14)23-3/h6-7,10-12,20H,5,8-9H2,1-4H3
InChiKey: GKFXVPXWFBFIAB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Sus scrofa	Tubulin	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma cruzi	tubulin gamma chain	Tubulin	445 aa	436 aa	33.5 %
Leishmania major	alpha tubulin	Tubulin	445 aa	434 aa	40.6 %
Schistosoma mansoni	tubulin subunit epsilon	Tubulin	445 aa	464 aa	31.5 %
Drosophila melanogaster	beta-Tubulin at 60D	Tubulin	445 aa	435 aa	91.3 %
Schistosoma japonicum	Tubulin alpha-1C chain, putative	Tubulin	445 aa	438 aa	38.8 %
Leishmania infantum	epsilon tubulin, putative	Tubulin	445 aa	475 aa	30.1 %
Echinococcus multilocularis	peroxisome assembly protein 26	Tubulin	445 aa	438 aa	29.0 %
Echinococcus multilocularis	Tubulin beta 2C chain	Tubulin	445 aa	430 aa	94.4 %
Onchocerca volvulus	60S ribosomal protein L13 homolog	Tubulin	445 aa	430 aa	91.9 %
Entamoeba histolytica	tubulin alpha chain, putative	Tubulin	445 aa	439 aa	35.8 %
Echinococcus multilocularis	tubulin alpha 3 chain	Tubulin	445 aa	434 aa	40.1 %
Leishmania mexicana	gamma-tubulin	Tubulin	445 aa	438 aa	34.2 %
Echinococcus multilocularis	tubulin alpha 1C chain	Tubulin	445 aa	434 aa	40.6 %
Entamoeba histolytica	tubulin alpha-1 chain	Tubulin	445 aa	439 aa	36.2 %
Plasmodium vivax	tubulin gamma chain, putative	Tubulin	445 aa	438 aa	33.1 %
Onchocerca volvulus		Tubulin	445 aa	441 aa	31.5 %
Schistosoma mansoni	tubulin subunit beta	Tubulin	445 aa	430 aa	92.6 %
Echinococcus granulosus	Tubulin alpha 1 chain	Tubulin	445 aa	434 aa	40.3 %
Schistosoma japonicum	ko:K10389 tubulin gamma, putative	Tubulin	445 aa	436 aa	33.9 %
Leishmania major	alpha tubulin	Tubulin	445 aa	434 aa	40.6 %
Echinococcus granulosus	tubulin beta 4A class IVa	Tubulin	445 aa	381 aa	71.4 %
Loa Loa (eye worm)	tubulin beta-1 chain	Tubulin	445 aa	432 aa	88.4 %
Leishmania major	alpha tubulin	Tubulin	445 aa	434 aa	40.6 %
Echinococcus granulosus	Tubulin beta 2C chain	Tubulin	445 aa	428 aa	92.3 %
Echinococcus multilocularis	tubulin alpha chain	Tubulin	445 aa	434 aa	40.1 %
Leishmania braziliensis	alpha tubulin	Tubulin	445 aa	434 aa	40.3 %
Plasmodium yoelii	tubulin gamma chain	Tubulin	445 aa	438 aa	32.9 %
Trichomonas vaginalis	tubulin epsilon chain, putative	Tubulin	445 aa	428 aa	80.8 %
Plasmodium vivax	tubulin epsilon chain, putative	Tubulin	445 aa	444 aa	28.2 %
Onchocerca volvulus		Tubulin	445 aa	434 aa	39.9 %
Echinococcus granulosus	Tubulin alpha 1 chain	Tubulin	445 aa	434 aa	40.8 %
Trypanosoma congolense	alpha tubulin	Tubulin	445 aa	434 aa	40.8 %
Leishmania major	alpha tubulin	Tubulin	445 aa	434 aa	40.6 %
Plasmodium falciparum	tubulin epsilon chain, putative	Tubulin	445 aa	461 aa	27.8 %
Giardia lamblia	Gamma tubulin	Tubulin	445 aa	460 aa	32.2 %
Brugia malayi	tubulin alpha chain - mouse	Tubulin	445 aa	433 aa	40.0 %
Schistosoma japonicum	ko:K07374 tubulin alpha, putative	Tubulin	445 aa	433 aa	39.3 %
Plasmodium berghei	alpha tubulin 2	Tubulin	445 aa	434 aa	41.2 %
Babesia bovis	tubulin gamma chain	Tubulin	445 aa	441 aa	34.2 %
Giardia lamblia	Epsilon tubulin	Tubulin	445 aa	442 aa	27.6 %
Leishmania major	alpha tubulin	Tubulin	445 aa	434 aa	40.6 %
Echinococcus granulosus	tubulin alpha 3 chain	Tubulin	445 aa	439 aa	40.3 %
Toxoplasma gondii	beta-1 tubulin, putative	Tubulin	445 aa	430 aa	89.1 %
Cryptosporidium parvum	gamma tubulin	Tubulin	445 aa	436 aa	37.4 %
Trypanosoma brucei	alpha tubulin	Tubulin	445 aa	434 aa	40.8 %
Trypanosoma brucei	epsilon tubulin	Tubulin	445 aa	446 aa	29.4 %
Echinococcus multilocularis	tubulin alpha 3 chain	Tubulin	445 aa	439 aa	40.3 %
Cryptosporidium hominis	gamma-tubulin	Tubulin	445 aa	436 aa	37.4 %
Toxoplasma gondii	beta-tubulin, putative	Tubulin	445 aa	430 aa	89.8 %
Onchocerca volvulus		Tubulin	445 aa	445 aa	36.2 %
Echinococcus multilocularis	Tubulin alpha 1 chain	Tubulin	445 aa	434 aa	40.3 %
Plasmodium berghei	alpha tubulin 1	Tubulin	445 aa	434 aa	40.3 %
Theileria parva	tubulin alpha chain, putative	Tubulin	445 aa	452 aa	36.7 %
Leishmania mexicana	alpha tubulin	Tubulin	445 aa	434 aa	40.6 %
Leishmania infantum	alpha tubulin	Tubulin	445 aa	434 aa	40.6 %
Echinococcus granulosus	tubulin alpha	Tubulin	445 aa	440 aa	30.2 %
Dictyostelium discoideum	alpha tubulin	Tubulin	445 aa	446 aa	41.0 %
Echinococcus granulosus	tubulin subunit TubB	Tubulin	445 aa	441 aa	30.6 %
Trichomonas vaginalis	tubulin gamma chain, putative	Tubulin	445 aa	415 aa	33.5 %
Neospora caninum	hypothetical protein	Tubulin	445 aa	430 aa	89.8 %
Trichomonas vaginalis	tubulin beta chain, putative	Tubulin	445 aa	434 aa	39.6 %
Trypanosoma brucei gambiense	epsilon tubulin	Tubulin	445 aa	446 aa	29.4 %
Leishmania mexicana	beta tubulin	Tubulin	445 aa	429 aa	86.2 %
Toxoplasma gondii	alpha tubulin TUBA1	Tubulin	445 aa	440 aa	40.5 %
Plasmodium berghei	tubulin epsilon chain, putative	Tubulin	445 aa	445 aa	29.4 %
Leishmania major	epsilon tubulin, putative	Tubulin	445 aa	465 aa	30.3 %
Echinococcus multilocularis	tubulin gamma 1 chain	Tubulin	445 aa	436 aa	34.2 %
Theileria parva	tubulin gamma chain, putative	Tubulin	445 aa	420 aa	34.3 %
Echinococcus multilocularis	tubulin subunit TubB	Tubulin	445 aa	441 aa	30.6 %
Plasmodium knowlesi	alpha-tubulin II, putative	Tubulin	445 aa	434 aa	41.2 %
Leishmania major	gamma-tubulin	Tubulin	445 aa	438 aa	34.0 %
Theileria parva	Tubulin alpha chain, putative	Tubulin	445 aa	439 aa	39.6 %
Neospora caninum	tubulin alpha chain	Tubulin	445 aa	440 aa	40.5 %
Giardia lamblia	Alpha-tubulin	Tubulin	445 aa	434 aa	40.3 %
Leishmania major	alpha tubulin	Tubulin	445 aa	434 aa	40.6 %
Schistosoma mansoni	tubulin subunit alpha	Tubulin	445 aa	439 aa	39.4 %
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	Tubulin	445 aa	433 aa	30.7 %
Trypanosoma brucei	alpha tubulin	Tubulin	445 aa	434 aa	40.8 %
Echinococcus granulosus	tubulin alpha chain	Tubulin	445 aa	434 aa	40.1 %
Leishmania major	alpha tubulin	Tubulin	445 aa	434 aa	40.6 %
Entamoeba histolytica	tubulin family protein	Tubulin	445 aa	429 aa	57.8 %
Loa Loa (eye worm)	BEN-1 protein	Tubulin	445 aa	427 aa	57.1 %
Loa Loa (eye worm)	tubulin beta-2A chain	Tubulin	445 aa	430 aa	91.9 %
Dictyostelium discoideum	gamma tubulin	Tubulin	445 aa	429 aa	33.8 %
Echinococcus multilocularis	tubulin alpha chain	Tubulin	445 aa	433 aa	33.5 %
Neospora caninum	hypothetical protein	Tubulin	445 aa	430 aa	89.1 %
Onchocerca volvulus	Putative cytochrome c-type heme lyase	Tubulin	445 aa	429 aa	87.9 %
Echinococcus granulosus	tubulin gamma 1 chain	Tubulin	445 aa	436 aa	34.2 %
Onchocerca volvulus	Regulatory-associated protein of mTOR homolog	Tubulin	445 aa	440 aa	38.6 %
Plasmodium knowlesi	alpha tubulin, putative	Tubulin	445 aa	434 aa	40.3 %
Plasmodium knowlesi	tubulin gamma chain, putative	Tubulin	445 aa	438 aa	33.1 %
Trichomonas vaginalis	tubulin beta chain, putative	Tubulin	445 aa	434 aa	39.6 %
Brugia malayi	beta-tubulin, identical	Tubulin	445 aa	430 aa	90.9 %
Loa Loa (eye worm)	BEN-1 protein	Tubulin	445 aa	427 aa	82.4 %
Toxoplasma gondii	alpha-tubulin I, putative	Tubulin	445 aa	442 aa	40.0 %
Echinococcus granulosus	Tubulin alpha 1 chain	Tubulin	445 aa	434 aa	38.9 %
Plasmodium falciparum	alpha tubulin 1	Tubulin	445 aa	434 aa	40.8 %
Onchocerca volvulus	Tyrosine kinase homolog	Tubulin	445 aa	434 aa	38.2 %
Plasmodium vivax	tubulin alpha chain, putative	Tubulin	445 aa	434 aa	41.2 %
Leishmania donovani	tubulin gamma chain	Tubulin	445 aa	438 aa	34.2 %
Onchocerca volvulus	Putative methyltransferase KIAA1456	Tubulin	445 aa	426 aa	49.8 %
Brugia malayi	Tubulin alpha-2 chain	Tubulin	445 aa	435 aa	38.6 %
Trichomonas vaginalis	tubulin alpha-1 chain, putative	Tubulin	445 aa	434 aa	39.6 %
Trypanosoma brucei gambiense	alpha tubulin	Tubulin	445 aa	434 aa	40.8 %
Onchocerca volvulus		Tubulin	445 aa	427 aa	82.7 %
Plasmodium berghei	tubulin gamma chain, putative	Tubulin	445 aa	438 aa	33.1 %
Trypanosoma cruzi	epsilon tubulin, putative	Tubulin	445 aa	456 aa	30.9 %
Echinococcus multilocularis	tubulin alpha 1C chain	Tubulin	445 aa	434 aa	39.9 %
Schistosoma japonicum	ko:K07374 tubulin alpha, putative	Tubulin	445 aa	433 aa	40.0 %
Giardia lamblia	Beta tubulin	Tubulin	445 aa	428 aa	88.8 %
Trypanosoma congolense	tubulin gamma chain	Tubulin	445 aa	436 aa	33.3 %
Echinococcus granulosus	tubulin alpha chain	Tubulin	445 aa	433 aa	33.5 %
Schistosoma mansoni	tubulin subunit beta	Tubulin	445 aa	430 aa	95.8 %
Echinococcus granulosus	tubulin alpha chain	Tubulin	445 aa	432 aa	35.0 %
Echinococcus multilocularis	tubulin alpha chain	Tubulin	445 aa	438 aa	34.5 %
Echinococcus multilocularis	Tubulin beta 2C chain	Tubulin	445 aa	428 aa	92.5 %
Drosophila melanogaster	gamma-Tubulin at 23C	Tubulin	445 aa	439 aa	34.4 %
Echinococcus multilocularis	Tubulin alpha 1 chain	Tubulin	445 aa	434 aa	40.8 %
Schistosoma japonicum	Tubulin beta chain, putative	Tubulin	445 aa	436 aa	96.6 %
Echinococcus multilocularis	hypothetical protein	Tubulin	445 aa	422 aa	29.9 %
Loa Loa (eye worm)	tubulin alpha chain	Tubulin	445 aa	432 aa	39.8 %
Brugia malayi	Tubulin beta-1 chain	Tubulin	445 aa	429 aa	87.9 %
Echinococcus granulosus	Tubulin beta 2C chain	Tubulin	445 aa	430 aa	95.1 %
Neospora caninum	hypothetical protein	Tubulin	445 aa	430 aa	89.1 %
Loa Loa (eye worm)	alpha-tubulin	Tubulin	445 aa	440 aa	38.2 %
Echinococcus multilocularis	tubulin alpha	Tubulin	445 aa	443 aa	30.5 %
Trypanosoma congolense	epsilon tubulin	Tubulin	445 aa	464 aa	29.3 %
Trichomonas vaginalis	tubulin, putative	Tubulin	445 aa	428 aa	80.8 %
Leishmania braziliensis	gamma-tubulin	Tubulin	445 aa	438 aa	34.2 %
Neospora caninum	tubulin alpha chain, putative	Tubulin	445 aa	433 aa	30.9 %
Entamoeba histolytica	tubulin family protein	Tubulin	445 aa	428 aa	56.3 %
Entamoeba histolytica	tubulin gamma chain	Tubulin	445 aa	428 aa	32.9 %
Plasmodium yoelii	tubulin alpha chain	Tubulin	445 aa	434 aa	40.3 %
Brugia malayi	alpha-tubulin	Tubulin	445 aa	434 aa	38.7 %
Leishmania infantum	alpha tubulin	Tubulin	445 aa	434 aa	40.6 %
Trichomonas vaginalis	tubulin beta chain, putative	Tubulin	445 aa	434 aa	39.6 %
Schistosoma mansoni	tubulin subunit gamma	Tubulin	445 aa	436 aa	33.5 %
Trichomonas vaginalis	tubulin epsilon chain, putative	Tubulin	445 aa	434 aa	39.6 %
Neospora caninum	Beta-tubulin, related	Tubulin	445 aa	446 aa	35.0 %
Plasmodium falciparum	tubulin gamma chain	Tubulin	445 aa	438 aa	32.6 %
Echinococcus granulosus	alpha tubulin	Tubulin	445 aa	422 aa	29.9 %
Giardia lamblia	Beta tubulin	Tubulin	445 aa	428 aa	88.8 %
Loa Loa (eye worm)	tubulin alpha-2 chain	Tubulin	445 aa	440 aa	39.1 %
Onchocerca volvulus	1D304 homolog	Tubulin	445 aa	433 aa	40.4 %
Trypanosoma brucei	alpha tubulin	Tubulin	445 aa	434 aa	40.8 %
Trypanosoma cruzi	epsilon tubulin, putative	Tubulin	445 aa	456 aa	30.9 %
Leishmania mexicana	epsilon tubulin, putative	Tubulin	445 aa	469 aa	30.5 %
Leishmania major	alpha tubulin	Tubulin	445 aa	434 aa	40.6 %
Echinococcus multilocularis	Tubulin alpha 1 chain	Tubulin	445 aa	434 aa	38.9 %
Trypanosoma cruzi	alpha tubulin, putative	Tubulin	445 aa	434 aa	40.6 %
Onchocerca volvulus		Tubulin	445 aa	427 aa	49.9 %
Leishmania donovani	epsilon tubulin, putative	Tubulin	445 aa	475 aa	30.1 %
Plasmodium falciparum	alpha tubulin 2	Tubulin	445 aa	434 aa	41.2 %
Echinococcus multilocularis	tubulin delta chain	Tubulin	445 aa	461 aa	26.0 %
Trichomonas vaginalis	tubulin beta chain, putative	Tubulin	445 aa	434 aa	39.6 %
Plasmodium vivax	tubulin alpha chain, putative	Tubulin	445 aa	434 aa	40.3 %
Leishmania braziliensis	alpha tubulin	Tubulin	445 aa	434 aa	40.3 %
Cryptosporidium parvum	alpha tubulin	Tubulin	445 aa	438 aa	40.2 %
Brugia malayi	tubulin alpha-2 chain	Tubulin	445 aa	440 aa	38.4 %
Leishmania infantum	gamma-tubulin	Tubulin	445 aa	438 aa	34.2 %
Schistosoma japonicum	Tubulin alpha-1 chain, putative	Tubulin	445 aa	439 aa	39.4 %
Babesia bovis	tubulin alpha chain, putative	Tubulin	445 aa	433 aa	40.6 %
Leishmania major	alpha tubulin	Tubulin	445 aa	434 aa	40.6 %
Echinococcus granulosus	tubulin alpha 3 chain	Tubulin	445 aa	434 aa	40.1 %
Cryptosporidium hominis	alpha-tubulin	Tubulin	445 aa	438 aa	40.2 %
Dictyostelium discoideum	beta tubulin	Tubulin	445 aa	432 aa	76.2 %
Leishmania mexicana	alpha tubulin	Tubulin	445 aa	434 aa	40.6 %
Onchocerca volvulus		Tubulin	445 aa	433 aa	39.0 %
Dictyostelium discoideum	hypothetical protein	Tubulin	445 aa	438 aa	38.6 %
Trichomonas vaginalis	tubulin alpha chain, putative	Tubulin	445 aa	428 aa	80.8 %
Trypanosoma brucei	epsilon tubulin	Tubulin	445 aa	446 aa	29.6 %
Echinococcus granulosus	beta tubulin	Tubulin	445 aa	427 aa	82.7 %
Leishmania major	alpha tubulin	Tubulin	445 aa	434 aa	40.6 %
Onchocerca volvulus		Tubulin	445 aa	435 aa	39.8 %
Babesia bovis	tubulin, putative	Tubulin	445 aa	457 aa	21.4 %
Brugia malayi	Tubulin gamma chain	Tubulin	445 aa	440 aa	31.4 %
Trypanosoma brucei	alpha tubulin	Tubulin	445 aa	434 aa	40.8 %
Schistosoma mansoni	alpha tubulin	Tubulin	445 aa	436 aa	39.7 %
Leishmania donovani	alpha tubulin	Tubulin	445 aa	434 aa	40.6 %
Trypanosoma brucei	epsilon tubulin	Tubulin	445 aa	446 aa	29.6 %
Schistosoma mansoni	tubulin subunit alpha	Tubulin	445 aa	434 aa	38.9 %
Schistosoma japonicum	Tubulin alpha chain, putative	Tubulin	445 aa	457 aa	36.8 %
Onchocerca volvulus		Tubulin	445 aa	433 aa	40.0 %
Trichomonas vaginalis	tubulin beta chain, putative	Tubulin	445 aa	434 aa	39.6 %
Toxoplasma gondii	beta tubulin	Tubulin	445 aa	430 aa	89.1 %
Echinococcus multilocularis	tubulin, beta 4A class IVa	Tubulin	445 aa	381 aa	71.4 %
Schistosoma mansoni	alpha tubulin	Tubulin	445 aa	434 aa	39.4 %
Trichomonas vaginalis	tubulin beta chain, putative	Tubulin	445 aa	428 aa	80.6 %
Leishmania major	alpha tubulin	Tubulin	445 aa	434 aa	40.6 %
Leishmania major	alpha tubulin	Tubulin	445 aa	434 aa	40.6 %
Trypanosoma brucei	tubulin gamma chain	Tubulin	445 aa	436 aa	33.5 %
Giardia lamblia	Alpha-tubulin	Tubulin	445 aa	434 aa	40.3 %
Leishmania braziliensis	epsilon tubulin, putative	Tubulin	445 aa	465 aa	29.9 %
Echinococcus granulosus	peroxisome assembly protein 26	Tubulin	445 aa	438 aa	29.2 %
Trypanosoma brucei gambiense	gamma tubulin	Tubulin	445 aa	436 aa	33.5 %
Plasmodium yoelii	tubulin beta chain	Tubulin	445 aa	445 aa	29.7 %
Echinococcus granulosus	tubulin alpha 1C chain	Tubulin	445 aa	434 aa	39.6 %
Giardia lamblia	Beta tubulin	Tubulin	445 aa	428 aa	88.8 %
Plasmodium knowlesi	tubulin epsilon chain, putative	Tubulin	445 aa	441 aa	29.0 %
Echinococcus granulosus	tubulin alpha 1C chain	Tubulin	445 aa	434 aa	40.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Trypsin family protein	0.0354	1	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0354	1	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0017	0	0.5
Trypanosoma brucei	epsilon tubulin	0.0017	0	0.5
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0354	1	1
Loa Loa (eye worm)	hypothetical protein	0.0354	1	1
Leishmania major	alpha tubulin	0.0017	0	0.5
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0354	1	1
Plasmodium falciparum	tubulin gamma chain	0.0017	0	0.5
Toxoplasma gondii	beta-tubulin, putative	0.0017	0	0.5
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0354	1	1
Leishmania major	beta tubulin	0.0017	0	0.5
Plasmodium vivax	tubulin alpha chain, putative	0.0017	0	0.5
Leishmania major	beta tubulin	0.0017	0	0.5
Trypanosoma brucei	alpha tubulin	0.0017	0	0.5
Plasmodium falciparum	alpha tubulin 2	0.0017	0	0.5
Leishmania major	beta tubulin	0.0017	0	0.5
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0017	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0354	1	1
Leishmania major	beta tubulin	0.0017	0	0.5
Schistosoma mansoni	cercarial elastase (S01 family)	0.0354	1	1
Echinococcus multilocularis	glycoprotein Antigen 5	0.0354	1	1
Onchocerca volvulus		0.0354	1	0.5
Schistosoma mansoni	hypothetical protein	0.0354	1	1
Trypanosoma brucei	epsilon tubulin	0.0017	0	0.5
Trypanosoma brucei	alpha tubulin	0.0017	0	0.5
Schistosoma mansoni	hypothetical protein	0.0354	1	1
Trypanosoma cruzi	epsilon tubulin, putative	0.0017	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0354	1	1
Trypanosoma cruzi	epsilon tubulin, putative	0.0017	0	0.5
Trichomonas vaginalis	tubulin gamma chain, putative	0.0017	0	0.5
Trichomonas vaginalis	tubulin beta chain, putative	0.0017	0	0.5
Leishmania major	beta tubulin	0.0017	0	0.5
Leishmania major	beta tubulin	0.0017	0	0.5
Leishmania major	beta tubulin	0.0017	0	0.5
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0354	1	1
Leishmania major	alpha tubulin	0.0017	0	0.5
Giardia lamblia	Beta tubulin	0.0017	0	0.5
Leishmania major	alpha tubulin	0.0017	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0354	1	1
Trypanosoma brucei	epsilon tubulin	0.0017	0	0.5
Onchocerca volvulus		0.0354	1	0.5
Giardia lamblia	Alpha-tubulin	0.0017	0	0.5
Brugia malayi	Trypsin family protein	0.0354	1	1
Leishmania major	beta tubulin	0.0017	0	0.5
Echinococcus granulosus	Mastin	0.0354	1	1
Giardia lamblia	Gamma tubulin	0.0017	0	0.5
Leishmania major	alpha tubulin	0.0017	0	0.5
Leishmania major	alpha tubulin	0.0017	0	0.5
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0017	0	0.5
Leishmania major	alpha tubulin	0.0017	0	0.5
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0354	1	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0017	0	0.5
Plasmodium vivax	tubulin alpha chain, putative	0.0017	0	0.5
Entamoeba histolytica	tubulin gamma chain	0.0017	0	0.5
Leishmania major	beta tubulin	0.0017	0	0.5
Leishmania major	beta tubulin	0.0017	0	0.5
Mycobacterium ulcerans	hypothetical protein	0.0354	1	0.5
Schistosoma mansoni	cercarial elastase (S01 family)	0.0354	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0017	0	0.5
Leishmania major	beta tubulin	0.0017	0	0.5
Entamoeba histolytica	tubulin family protein	0.0017	0	0.5
Leishmania major	alpha tubulin	0.0017	0	0.5
Trichomonas vaginalis	tubulin beta chain, putative	0.0017	0	0.5
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0354	1	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0354	1	1
Trypanosoma cruzi	beta tubulin, putative	0.0017	0	0.5
Schistosoma mansoni	cercarial elastase (S01 family)	0.0354	1	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0017	0	0.5
Trichomonas vaginalis	tubulin, putative	0.0017	0	0.5
Schistosoma mansoni	cercarial elastase (S01 family)	0.0354	1	1
Entamoeba histolytica	tubulin alpha-1 chain	0.0017	0	0.5
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0354	1	1
Trypanosoma brucei	beta tubulin	0.0017	0	0.5
Trypanosoma brucei	beta tubulin	0.0017	0	0.5
Leishmania major	alpha tubulin	0.0017	0	0.5
Brugia malayi	Trypsin-like protease protein 5	0.0354	1	1
Loa Loa (eye worm)	hypothetical protein	0.0354	1	1
Leishmania major	epsilon tubulin, putative	0.0017	0	0.5
Leishmania major	beta tubulin	0.0017	0	0.5
Loa Loa (eye worm)	trypsin family protein	0.0354	1	1
Plasmodium vivax	tubulin gamma chain, putative	0.0017	0	0.5
Trichomonas vaginalis	tubulin beta chain, putative	0.0017	0	0.5
Plasmodium vivax	tubulin epsilon chain, putative	0.0017	0	0.5
Entamoeba histolytica	tubulin alpha chain, putative	0.0017	0	0.5
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0354	1	1
Giardia lamblia	Beta tubulin	0.0017	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0354	1	1
Trypanosoma brucei	alpha tubulin	0.0017	0	0.5
Schistosoma mansoni	cercarial elastase (S01 family)	0.0354	1	1
Echinococcus multilocularis	enteropeptidase	0.0354	1	1
Toxoplasma gondii	beta-1 tubulin, putative	0.0017	0	0.5
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0017	0	0.5
Trypanosoma brucei	beta tubulin	0.0017	0	0.5
Echinococcus multilocularis	Mastin	0.0354	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0017	0	0.5
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0354	1	1
Toxoplasma gondii	alpha tubulin TUBA1	0.0017	0	0.5
Giardia lamblia	Alpha-tubulin	0.0017	0	0.5
Echinococcus multilocularis	transmembrane protease serine 3	0.0354	1	1
Trypanosoma brucei	beta tubulin	0.0017	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0354	1	1
Onchocerca volvulus		0.0354	1	0.5
Onchocerca volvulus		0.0354	1	0.5
Trypanosoma brucei	tubulin gamma chain	0.0017	0	0.5
Trypanosoma brucei	beta tubulin	0.0017	0	0.5
Giardia lamblia	Beta tubulin	0.0017	0	0.5
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0354	1	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0017	0	0.5
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0017	0	0.5
Trypanosoma cruzi	alpha tubulin, putative	0.0017	0	0.5
Leishmania major	gamma-tubulin	0.0017	0	0.5
Toxoplasma gondii	alpha-tubulin I, putative	0.0017	0	0.5
Brugia malayi	hypothetical protein	0.0354	1	1
Leishmania major	beta tubulin	0.0017	0	0.5
Leishmania major	beta tubulin	0.0017	0	0.5
Plasmodium falciparum	tubulin beta chain	0.0017	0	0.5
Trichomonas vaginalis	tubulin beta chain, putative	0.0017	0	0.5
Leishmania major	beta tubulin	0.0017	0	0.5
Trichomonas vaginalis	tubulin beta chain, putative	0.0017	0	0.5
Echinococcus granulosus	enteropeptidase	0.0354	1	1
Onchocerca volvulus		0.0354	1	0.5
Echinococcus granulosus	transmembrane protease serine 3	0.0354	1	1
Plasmodium falciparum	tubulin epsilon chain, putative	0.0017	0	0.5
Trypanosoma brucei	alpha tubulin	0.0017	0	0.5
Trichomonas vaginalis	tubulin gamma chain, putative	0.0017	0	0.5
Leishmania major	beta tubulin	0.0017	0	0.5
Schistosoma mansoni	cercarial elastase (S01 family)	0.0354	1	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0354	1	1
Leishmania major	alpha tubulin	0.0017	0	0.5
Brugia malayi	Trypsin family protein	0.0354	1	1
Plasmodium falciparum	alpha tubulin 1	0.0017	0	0.5
Trichomonas vaginalis	tubulin alpha chain, putative	0.0017	0	0.5
Toxoplasma gondii	beta tubulin	0.0017	0	0.5
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0354	1	1
Plasmodium vivax	tubulin beta chain, putative	0.0017	0	0.5
Schistosoma mansoni	cercarial elastase (S01 family)	0.0354	1	1
Leishmania major	alpha tubulin	0.0017	0	0.5
Leishmania major	beta tubulin	0.0017	0	0.5
Onchocerca volvulus		0.0354	1	0.5
Leishmania major	alpha tubulin	0.0017	0	0.5
Schistosoma mansoni	cercarial elastase (S01 family)	0.0354	1	1
Echinococcus granulosus	glycoprotein Antigen 5	0.0354	1	1
Leishmania major	alpha tubulin	0.0017	0	0.5
Trypanosoma cruzi	tubulin gamma chain	0.0017	0	0.5
Leishmania major	beta tubulin	0.0017	0	0.5
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0354	1	1
Entamoeba histolytica	tubulin family protein	0.0017	0	0.5
Schistosoma mansoni	cercarial elastase (S01 family)	0.0354	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 0.062 uM	Cytotoxicity against human MCF7 cells after 3 days	ChEMBL.	24139940
IC50 (binding)	= 11.8 uM	Inhibition of porcine brain tubulin polymerization by turbidity assay	ChEMBL.	24139940
Inhibition (binding)	= 87 %	Inhibition of porcine brain tubulin polymerization at 30 uM by turbidity assay	ChEMBL.	24139940
Inhibition (binding)	= 88.1 %	Displacement of [3H]colchicine from tubulin (unknown origin) at 3 uM after 30 mins by scintillation counting	ChEMBL.	24139940
Inhibition (binding)	= 98.3 %	Displacement of [3H]colchicine from tubulin (unknown origin) at 30 uM after 30 mins by scintillation counting	ChEMBL.	24139940
Inhibition (binding)	= 99 %	Displacement of [3H]colchicine from tubulin (unknown origin) at 10 uM after 30 mins by scintillation counting	ChEMBL.	24139940

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	24139940

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3093567

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1829950