TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 531.671 | Formula: C25H37N7O4S
H donors: 4 H acceptors: 5 LogP: 2.57 Rotable bonds: 12
Rule of 5 violations (Lipinski): 2
SMILES: CCCCNc1ncc(c(n1)NC[C@@H]1CCCNC1)C(=O)Nc1ccc(cc1)S(=O)(=O)N1CCOCC1
InChi: 1S/C25H37N7O4S/c1-2-3-11-27-25-29-18-22(23(31-25)28-17-19-5-4-10-26-16-19)24(33)30-20-6-8-21(9-7-20)37(34,35)32-12-14-36-15-13-32/h6-9,18-19,26H,2-5,10-17H2,1H3,(H,30,33)(H2,27,28,29,31)/t19-/m1/s1
InChiKey: JGSVNIPAOGOWTI-LJQANCHMSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	TYRO3 protein tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	MER proto-oncogene, tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	AXL receptor tyrosine kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	IPR008957,Fibronectin, type III-like fold,domain-containing	Get druggable targets OG5_132328	All targets in OG5_132328

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	cathepsin L-like protease	0.0044	0.0349	0.0097
Brugia malayi	Cathepsin L-like precursor	0.0044	0.0349	0.0439
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0044	0.0349	0.0349
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0542	0.6709	0.8447
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0044	0.0349	0.3941
Schistosoma mansoni	hypothetical protein	0.0254	0.3039	0.3826
Schistosoma mansoni	hypothetical protein	0.0017	0.0006	0.0008
Echinococcus multilocularis	inositol monophosphatase 1	0.0039	0.0286	0.0286
Brugia malayi	cathepsin L precursor	0.0017	0.0005	0.0006
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0405	0.051
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.0131	0.1463	0.1463
Schistosoma mansoni	hypothetical protein	0.0036	0.0248	0.0312
Brugia malayi	Matrixin family protein	0.0036	0.0248	0.0312
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0405	0.051
Brugia malayi	Serine/threonine-protein kinase Pim-3	0.0638	0.7943	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0053	0.0461	0.058
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	0.0638	0.7943	1
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0017	0.0006	0.0008
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0017	0.0006	0.0008
Brugia malayi	hypothetical protein	0.0025	0.0104	0.0131
Brugia malayi	Cathepsin L-like precursor	0.0044	0.0349	0.0439
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0044	0.0349	0.0439
Leishmania major	cathepsin L-like protease	0.0044	0.0349	0.0097
Brugia malayi	Cathepsin L-like precursor	0.0044	0.0349	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0006	0.0008
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0021	0.0053	0.0053
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0018	0.0012	0.0012
Leishmania major	cysteine peptidase A (CPA)	0.0044	0.0349	0.0097
Leishmania major	cathepsin L-like protease	0.0044	0.0349	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0006
Trypanosoma cruzi	cysteine peptidase, putative	0.0044	0.0349	0.0513
Schistosoma mansoni	nephrin	0.0021	0.0053	0.0067
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0017	0.0005	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0348	0.0439
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0349	0.0513
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0349	0.0439
Brugia malayi	Matrixin family protein	0.0036	0.0248	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0248	0.0312
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0019	0.0036	0.0045
Schistosoma mansoni	cell adhesion molecule	0.0021	0.0053	0.0067
Brugia malayi	Cathepsin L-like precursor	0.0044	0.0349	0.0439
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.0349	0.3941
Echinococcus granulosus	carbonic anhydrase	0.0254	0.3039	0.3826
Loa Loa (eye worm)	cysteine protease	0.0044	0.0349	0.0439
Schistosoma mansoni	matrix metallopeptidase-7 (M10 family)	0.0036	0.0248	0.0312
Onchocerca volvulus	Cathepsin F homolog	0.0044	0.0349	0.0433
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.0349	0.3941
Echinococcus multilocularis	transfer RNA-Phe	0.0017	0.0006	0.0006
Echinococcus granulosus	cathepsin b	0.0238	0.2826	0.3558
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0542	0.6709	1
Toxoplasma gondii	hypothetical protein	0.0254	0.3039	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.0349	0.3941
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0085	0.0877	1
Schistosoma mansoni	matrix metallopeptidase-9 (M10 family)	0.0024	0.01	0.0125
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.0349	0.3941
Brugia malayi	Hemopexin family protein	0.0051	0.0441	0.0555
Schistosoma mansoni	nephrin	0.0028	0.015	0.0189
Onchocerca volvulus		0.0017	0.0006	0.0002
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.0349	0.3941
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0349	0.3941
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0248	0.0312
Onchocerca volvulus		0.0036	0.0248	0.0306
Loa Loa (eye worm)	CAMK protein kinase	0.0019	0.0036	0.0045
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0254	0.3039	0.3826
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0349	0.0439
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0017	0.0005	0.0006
Brugia malayi	protein unc-22	0.0019	0.0036	0.0045
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0017	0.0005	0.0006
Brugia malayi	cathepsin F-like cysteine proteinase	0.0017	0.0005	0.0006
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0085	0.0877	0.1301
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0021	0.0053	0.0067
Echinococcus granulosus	carbonic anhydrase	0.0254	0.3039	0.3826
Echinococcus granulosus	roundabout 2	0.0021	0.0053	0.0067
Brugia malayi	Cathepsin L-like precursor	0.0044	0.0349	0.0439
Schistosoma mansoni	carbonic anhydrase-related	0.0254	0.3039	0.3826
Echinococcus multilocularis	cathepsin b	0.0238	0.2826	0.2826
Echinococcus multilocularis	cathepsin L cysteine protease	0.0044	0.0349	0.0349
Entamoeba histolytica	cysteine proteinase, putative	0.0044	0.0349	1
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0039	0.0286	0.0928
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0085	0.0877	0.1105
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0019	0.0036	0.0045
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0349	0.3941
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0053	0.0461	0.058
Onchocerca volvulus	Matrix metalloproteinase homolog	0.008	0.081	0.1014
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0044	0.0349	0.0439
Echinococcus granulosus	carbonic anhydrase	0.0254	0.3039	0.3826
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0405	0.051
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0021	0.0053	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0461	0.058
Onchocerca volvulus		0.0044	0.0349	0.0433
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0238	0.2826	0.3558
Onchocerca volvulus		0.0044	0.0349	0.0433
Schistosoma mansoni	neuroglian	0.0021	0.0053	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0104	0.0131
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0085	0.0877	0.1301
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.0005	0.0006
Trypanosoma brucei	carbonic anhydrase-like protein	0.0542	0.6709	1
Schistosoma mansoni	inositol monophosphatase	0.0039	0.0286	0.036
Onchocerca volvulus	Matrilysin homolog	0.0036	0.0248	0.0306
Onchocerca volvulus		0.0044	0.0349	0.0433
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0017	0.0005	0.0006
Brugia malayi	cathepsin B-like cysteine proteinase	0.0238	0.2826	0.3558
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0017	0.0007	0.0009
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0638	0.7943	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0349	0.3941
Schistosoma mansoni	hypothetical protein	0.0051	0.0441	0.0555
Echinococcus granulosus	cathepsin L	0.0017	0.0005	0.0006
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0044	0.0349	0.1134
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0254	0.3039	0.3826
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0039	0.0286	0.042
Loa Loa (eye worm)	projectin	0.0017	0.0006	0.0008
Entamoeba histolytica	cysteine proteinase, putative	0.0044	0.0349	1
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0017	0.0006	0.0008
Loa Loa (eye worm)	matrixin family protein	0.0087	0.0902	0.1135
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0044	0.0349	0.0513
Mycobacterium tuberculosis	Probable peptidoglycan hydrolase	0.0044	0.0348	0.0288
Mycobacterium leprae	PROBABLE HYDROLASE	0.0044	0.0348	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0248	0.0312
Onchocerca volvulus	Serine\/threonine protein kinase homolog	0.0638	0.7943	1
Echinococcus granulosus	roundabout 2	0.0032	0.0197	0.0248
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.0005	0.0006
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0349	0.3941
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0017	0.0005	0.0006
Echinococcus multilocularis	neuroglian	0.0021	0.0053	0.0053
Brugia malayi	Cathepsin L-like precursor	0.0044	0.0349	0.0439
Giardia lamblia	Cathepsin B precursor	0.0085	0.0877	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0346	0.4203	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0006
Brugia malayi	Matrixin family protein	0.0087	0.0902	0.1135
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0104	0.0131
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0542	0.6709	0.8447
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0349	0.0439
Brugia malayi	Matrixin family protein	0.0036	0.0248	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0006
Loa Loa (eye worm)	ctsf protein	0.0044	0.0349	0.0439
Onchocerca volvulus		0.0044	0.0349	0.0433
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0023	0.0082	0.0104
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0017	0.0005	0.0006
Trypanosoma cruzi	cysteine peptidase, putative	0.0044	0.0349	0.0513
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	0.0638	0.7943	0.7943
Echinococcus granulosus	cathepsin l1	0.0044	0.0349	0.0439
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0018	0.0012	0.0015
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0349	0.0513
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0017	0.0007	0.0009
Echinococcus granulosus	Down syndrome cell adhesion molecule	0.0017	0.0007	0.0009
Echinococcus granulosus	carbonic anhydrase II	0.0542	0.6709	0.8447
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0349	0.0513
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0044	0.0349	0.1134
Giardia lamblia	Cathepsin B precursor	0.0085	0.0877	1
Echinococcus granulosus	inositol monophosphatase 1	0.0039	0.0286	0.036
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0349	0.3941
Onchocerca volvulus		0.0017	0.0006	0.0002
Echinococcus granulosus	roundabout 2	0.0021	0.0053	0.0067
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0349	0.0513
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0405	0.051
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0104	0.0131
Loa Loa (eye worm)	fibroinase	0.0044	0.0349	0.0439
Entamoeba histolytica	cysteine protease, putative	0.0044	0.0349	1
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0085	0.0877	0.092
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0021	0.0053	0.0067
Schistosoma mansoni	cathepsin C	0.0017	0.0005	0.0006
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0238	0.2826	0.3558
Schistosoma mansoni	inositol monophosphatase	0.0039	0.0286	0.036
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.0349	0.3941
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0254	0.3039	0.3826
Echinococcus multilocularis	cathepsin L	0.0017	0.0005	0.0005
Echinococcus multilocularis	carbonic anhydrase	0.0254	0.3039	0.3039
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0542	0.6709	0.8447
Schistosoma mansoni	titin	0.0019	0.0036	0.0045
Onchocerca volvulus	Cathepsin L homolog	0.0044	0.0349	0.0433
Echinococcus multilocularis	carbonic anhydrase II	0.0542	0.6709	0.6709
Entamoeba histolytica	cysteine proteinase, putative	0.0044	0.0349	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0346	0.4203	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0405	0.0405
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0039	0.0286	0.042
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.0005	0.0006
Plasmodium vivax	vivapain-2	0.0044	0.0349	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0021	0.0053	0.0067
Echinococcus multilocularis	cathepsin b	0.0238	0.2826	0.2826
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0349	0.3941
Onchocerca volvulus		0.0044	0.0349	0.0433
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0029
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0039	0.0286	0.3226
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0053	0.0461	0.058
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0017	0.0005	0.0006
Schistosoma mansoni	cell adhesion molecule	0.0028	0.0151	0.019
Toxoplasma gondii	cathepsin B	0.0085	0.0877	0.2876
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.0248	0.0312
Toxoplasma gondii	cathepsin CPL	0.0044	0.0349	0.1134
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0017	0.0006	0.0008
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0349	0.3941
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0017	0.0006	0.0008
Brugia malayi	Fibronectin type III domain containing protein	0.0025	0.0104	0.0131
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0405	0.0405
Onchocerca volvulus		0.0044	0.0349	0.0433
Echinococcus granulosus	nephrin	0.0017	0.0006	0.0008
Schistosoma mansoni	cathepsin F (C01 family)	0.0044	0.0349	0.0439
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0017	0.0005	0.0006
Echinococcus granulosus	titin	0.0019	0.0036	0.0045
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.0349	0.3941
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0017	0.0005	0.0006
Echinococcus granulosus	cathepsin b	0.0238	0.2826	0.3558
Brugia malayi	Papain family cysteine protease containing protein	0.0044	0.0349	0.0439
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0044	0.0349	0.0439
Giardia lamblia	Cathepsin B precursor	0.0085	0.0877	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0349	0.0513
Mycobacterium ulcerans	hydrolase	0.0044	0.0348	0.0158
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0019	0.0028	0.0035
Schistosoma mansoni	carbonic anhydrase-related	0.0254	0.3039	0.3826
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0017	0.0005	0.0006
Leishmania major	cathepsin L-like protease	0.0044	0.0349	0.0097
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0349	0.3941
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0017	0.0006	0.0008
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0048	0.0405	0.051
Echinococcus multilocularis	roundabout 2	0.0021	0.0053	0.0053
Brugia malayi	Matrixin family protein	0.0036	0.0248	0.0312
Brugia malayi	cathepsin L-like precursor	0.0044	0.0349	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0029
Onchocerca volvulus	Cathepsin L homolog	0.0044	0.0349	0.0433
Echinococcus multilocularis	carbonic anhydrase	0.0254	0.3039	0.3039
Brugia malayi	Inositol-1	0.0039	0.0286	0.036
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0542	0.6709	0.8447
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0017	0.0006	0.0008
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0039	0.0286	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0349	0.3941
Schistosoma mansoni	carbonic anhydrase	0.0254	0.3039	0.3826
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0036	0.0045
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0238	0.2826	0.4208
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0254	0.3039	0.3826
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0044	0.0349	0.0439
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0017	0.0006	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0349	0.0439
Schistosoma mansoni	cathepsin F (C01 family)	0.0044	0.0349	0.0439
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0044	0.0349	0.3941
Loa Loa (eye worm)	carbonic anhydrase 3	0.0542	0.6709	0.8447
Schistosoma mansoni	cathepsin B (C01 family)	0.0017	0.0005	0.0006
Echinococcus granulosus	contactin	0.0021	0.0053	0.0067
Schistosoma mansoni	serine/threonine protein kinase	0.0638	0.7943	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0044	0.0349	0.0513
Schistosoma mansoni	cathepsin S (C01 family)	0.0017	0.0005	0.0006
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0638	0.7943	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0021	0.0053	0.0053
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0017	0.0005	0.0006
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0349	0.0513
Onchocerca volvulus		0.0044	0.0349	0.0433
Echinococcus multilocularis	cysteine protease	0.0044	0.0349	0.0349
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0349	0.3941
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0017	0.0005	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0248	0.0312
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0542	0.6709	0.8447
Echinococcus multilocularis	cathepsin L cysteine protease	0.0044	0.0349	0.0349
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0238	0.2826	0.3558
Echinococcus multilocularis	cathepsin L	0.0017	0.0005	0.0005
Brugia malayi	Cathepsin L-like precursor	0.0044	0.0349	0.0439
Echinococcus multilocularis	roundabout 2	0.0032	0.0197	0.0197
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	0.0131	0.1463	0.1843
Schistosoma mansoni	hemicentin	0.0017	0.0006	0.0008
Schistosoma mansoni	myosin-binding protein-related	0.0017	0.0006	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0053	0.0067
Echinococcus granulosus	cathepsin l1	0.0044	0.0349	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0254	0.3039	0.3826
Loa Loa (eye worm)	matrixin family protein	0.008	0.081	0.1019
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0017	0.0006	0.0008
Schistosoma mansoni	carbonic anhydrase-related	0.0254	0.3039	0.3826
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0021	0.0053	0.0053
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0017	0.0005	0.0006
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.0005	0.0006
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0025	0.0104	0.0131
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0039	0.0286	0.3226
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0254	0.3039	0.3826
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.0349	0.3941
Schistosoma mansoni	cell adhesion molecule	0.0017	0.0006	0.0008
Schistosoma mansoni	titin	0.0017	0.0006	0.0008
Trichomonas vaginalis	inositol monophosphatase, putative	0.0039	0.0286	0.3226
Leishmania major	cathepsin L-like protease	0.0044	0.0349	0.0097
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0349	0.0513
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0349	0.3941
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0021	0.0053	0.0067
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0019	0.0028	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0238	0.2826	0.3558
Brugia malayi	fibroinase precursor	0.0017	0.0005	0.0006
Echinococcus multilocularis	Down syndrome cell adhesion molecule	0.0017	0.0007	0.0007
Schistosoma mansoni	ephrin receptor	0.0018	0.0012	0.0015
Echinococcus multilocularis	cysteine protease	0.0044	0.0349	0.0349
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0349	0.3941
Onchocerca volvulus	Matrilysin homolog	0.008	0.081	0.1014
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0044	0.0349	0.0349
Brugia malayi	cathepsin L-like cysteine proteinase	0.0017	0.0005	0.0006
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0349	0.3941
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0017	0.0005	0.0006
Trypanosoma cruzi	cruzipain precursor, putative	0.0044	0.0349	0.0513
Plasmodium falciparum	carbonic anhydrase	0.0254	0.3039	1
Loa Loa (eye worm)	inositol-1	0.0039	0.0286	0.036
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0021	0.0053	0.0067
Brugia malayi	Cathepsin L-like precursor	0.0044	0.0349	0.0439
Echinococcus granulosus	neuroglian	0.0021	0.0053	0.0067
Echinococcus granulosus	titin	0.0019	0.0036	0.0045
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0017	0.0005	0.0006
Echinococcus granulosus	cathepsin L cysteine protease	0.0017	0.0005	0.0006
Schistosoma mansoni	cell adhesion molecule	0.0021	0.0053	0.0067
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0254	0.3039	0.3826
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0349	0.0513
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0006	0.0008
Echinococcus granulosus	cysteine protease	0.0017	0.0005	0.0006
Schistosoma mansoni	cathepsin F (C01 family)	0.0044	0.0349	0.0439
Brugia malayi	Protein kinase domain containing protein	0.0638	0.7943	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0006
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0017	0.0005	0.0006
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0017	0.0005	0.0006
Echinococcus granulosus	cathepsin L	0.0017	0.0005	0.0006
Echinococcus multilocularis	carbonic anhydrase	0.0254	0.3039	0.3039
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0017	0.0006	0.0008
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0349	0.0513
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0021	0.0053	0.0067
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0039	0.0286	0.042
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0405	0.051
Leishmania major	carbonic anhydrase-like protein	0.0542	0.6709	1
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0254	0.3039	0.3826
Echinococcus multilocularis	roundabout 2	0.0021	0.0053	0.0053
Onchocerca volvulus		0.0019	0.0036	0.0039
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0349	0.3941
Loa Loa (eye worm)	hypothetical protein	0.0254	0.3039	0.3826
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0238	0.2826	0.3558
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.0349	0.3941
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0048	0.0405	0.051
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.0005	0.0006
Loa Loa (eye worm)	cathepsin B	0.0085	0.0877	0.1105
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0039	0.0286	0.8186
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0044	0.0349	0.1134
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0349	0.0513
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0044	0.0349	0.0439
Onchocerca volvulus		0.0044	0.0349	0.0433
Brugia malayi	Matrix metalloprotease, N-terminal domain containing protein	0.0044	0.0348	0.0439
Echinococcus multilocularis	titin	0.0019	0.0036	0.0036
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0017	0.0005	0.0006
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0349	0.0513
Leishmania major	cathepsin L-like protease	0.0044	0.0349	0.0097
Echinococcus granulosus	twitchin	0.0017	0.0005	0.0007
Leishmania major	cathepsin L-like protease	0.0044	0.0349	0.0097
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0349	0.3941
Trypanosoma cruzi	cysteine peptidase, putative	0.0044	0.0349	0.0513
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0542	0.6709	1
Schistosoma mansoni	cell adhesion molecule	0.0017	0.0006	0.0008
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0349	0.3941
Onchocerca volvulus		0.0051	0.0441	0.0549
Loa Loa (eye worm)	matrix metalloproteinase	0.0036	0.0248	0.0312
Leishmania major	cathepsin L-like protease	0.0044	0.0349	0.0097
Plasmodium vivax	vivapain-2	0.0044	0.0349	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0006

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.14 uM	Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay	ChEMBL.	24219778
IC50 (binding)	= 1.6 uM	Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay	ChEMBL.	24219778
IC50 (binding)	= 14 uM	Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay	ChEMBL.	24219778

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3093638

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1830352