Detailed information for compound 1848405

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 207.181 | Formula: C7H13NO6
  • H donors: 6 H acceptors: 6 LogP: -4.45 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC[C@@H]1N[C@@H](C(=O)O)[C@@H]([C@H]([C@H]1O)O)O
  • InChi: 1S/C7H13NO6/c9-1-2-4(10)6(12)5(11)3(8-2)7(13)14/h2-6,8-12H,1H2,(H,13,14)/t2-,3+,4-,5-,6-/m0/s1
  • InChiKey: AKOVXLYFOWLQSJ-GNFDWLABSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0168 0.516
Schistosoma mansoni atypical protein kinase C 0.0032 0.0108 0.0108
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0116 0.0116
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0042 0.0042
Trypanosoma cruzi V-type ATPase, A subunit, putative 0.0024 0.0061 0.1726
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0033 0.0033
Trypanosoma cruzi V-type ATPase, A subunit, putative 0.0024 0.0061 0.1726
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0042 0.0327
Treponema pallidum V-type ATP synthase subunit B 0.0047 0.02 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0057 0.0057
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0042 0.0042
Entamoeba histolytica deoxycytidyl transferase, putative 0.0015 0.0007 0.0211
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0042 0.0042
Brugia malayi ATP synthase beta chain, mitochondrial precursor, putative 0.0043 0.0173 0.0173
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0042 0.0042
Echinococcus granulosus vacuolar H ATPase v1 sector subunit A 0.0024 0.0061 0.0061
Echinococcus granulosus GPCR family 2 0.0026 0.0071 0.0071
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0168 0.516
Echinococcus granulosus lamin dm0 0.0023 0.0057 0.0057
Plasmodium vivax vacuolar ATP synthase subunit b, putative 0.0047 0.02 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0107 0.0107
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0038 0.0146 0.0146
Schistosoma mansoni transcription factor LCR-F1 0.0059 0.0266 0.0266
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0061 0.1729
Schistosoma mansoni serine/threonine kinase 0.0019 0.003 0.003
Trichomonas vaginalis AGC family protein kinase 0.0019 0.003 0.0267
Mycobacterium leprae PROBABLE ATP SYNTHASE BETA CHAIN ATPD 0.0066 0.0311 1
Toxoplasma gondii exonuclease III APE 0.0019 0.0033 0.049
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0319 0.0319
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0042 0.0042
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0019 0.003 0.003
Brugia malayi vacuolar ATP synthase subunit B 0.0047 0.02 0.02
Leishmania major DNA polymerase kappa, putative 0.0022 0.0047 0.128
Brugia malayi hypothetical protein 0.0204 0.1124 0.1124
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0085 0.0422 0.0422
Echinococcus multilocularis ATPase, H+ transporting, lysosomal accessory 0.0123 0.0645 0.0645
Loa Loa (eye worm) hypothetical protein 0.0134 0.0715 0.0715
Treponema pallidum flagellum-specific ATP synthase (fliI) 0.0043 0.0173 0.8412
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0059 0.0266 0.0266
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0319 1
Trypanosoma brucei Vacuolar proton pump subunit B, putative 0.0047 0.02 0.6191
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0105 0.0539 0.0539
Loa Loa (eye worm) vacuolar ATP synthase subunit B 0.0047 0.02 0.02
Entamoeba histolytica hypothetical protein 0.0024 0.0061 0.1903
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0042 0.0042
Treponema pallidum V-type ATP synthase subunit B 0.0047 0.02 1
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0019 0.003 0.003
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0042 0.0042
Loa Loa (eye worm) AGC/NDR protein kinase 0.0019 0.003 0.003
Trichomonas vaginalis AGC family protein kinase 0.0019 0.003 0.0267
Loa Loa (eye worm) hypothetical protein 0.0026 0.0071 0.0071
Schistosoma mansoni hypothetical protein 0.0059 0.0266 0.0266
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0105 0.0539 0.0539
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0042 0.0042
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0059 0.0266 0.0266
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0042 0.0042
Giardia lamblia Vacuolar ATP synthase catalytic subunit A 0.0024 0.0061 0.1654
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0042 0.0042
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0168 0.8142
Entamoeba histolytica hypothetical protein 0.0059 0.0266 0.8335
Loa Loa (eye worm) vacuolar H ATPase family member 0.0024 0.0061 0.0061
Leishmania major ATPase alpha subunit 0.0034 0.0118 0.3552
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0042 0.0042
Onchocerca volvulus 0.0023 0.0057 0.0462
Echinococcus granulosus ATP synthase subunit alpha mitochondrial 0.0047 0.0198 0.0198
Echinococcus multilocularis L aminoadipate semialdehyde 0.0085 0.0422 0.0422
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0042 0.0042
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.015 0.015
Trichomonas vaginalis AGC family protein kinase 0.0019 0.003 0.0267
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0042 0.0042
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0033 0.0841
Brugia malayi p70 ribosomal S6 kinase beta 0.0019 0.003 0.003
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0033 0.0033
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0168 0.516
Echinococcus granulosus unc 13 munc13 0.0014 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0081 0.0399 0.0399
Toxoplasma gondii vacuolar ATP synthase subunit b, putative 0.0047 0.02 0.3626
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.007 0.0332 0.0332
Brugia malayi Latrophilin receptor protein 2 0.0026 0.0071 0.0071
Chlamydia trachomatis V-type ATP synthase subunit B 0.0047 0.02 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0042 0.0042
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0015 0.0007 0.0007
Echinococcus granulosus ATP synthase subunit beta mitochondrial 0.0043 0.0173 0.0173
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0042 0.0168 0.1489
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0014 0.0005 0.0005
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0042 0.0042
Echinococcus granulosus transcription factor Dp 1 0.0039 0.015 0.015
Echinococcus multilocularis RNA directed DNA polymerase 0.0038 0.0146 0.0146
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0168 0.516
Trichomonas vaginalis AGC family protein kinase 0.0019 0.003 0.0267
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0042 0.0042
Echinococcus granulosus serine:threonine protein kinase N2 0.0019 0.003 0.003
Schistosoma mansoni terminal deoxycytidyl transferase 0.0015 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0129 0.0681 0.0681
Brugia malayi Hr1 repeat family protein 0.0019 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0005
Brugia malayi hypothetical protein 0.0123 0.0648 0.0648
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0061 0.1771
Trichomonas vaginalis AGC family protein kinase 0.0019 0.003 0.0267
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0168 0.516
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0168 0.516
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0026 0.0071 0.0071
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0661 0.3831 0.3831
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0042 0.0042
Brugia malayi hypothetical protein 0.0059 0.0266 0.0266
Trypanosoma brucei ATP synthase F1, alpha subunit 0.0034 0.0118 0.3552
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0042 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.002 0.0408
Onchocerca volvulus 0.0023 0.0057 0.0462
Trichomonas vaginalis ATP synthase, putative 0.0047 0.02 0.1775
Echinococcus granulosus intermediate filament protein 0.0023 0.0057 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0042 0.0042
Echinococcus multilocularis unc 13 (munc13) 0.0014 0.0005 0.0005
Onchocerca volvulus 0.0026 0.0071 0.0593
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0061 0.1674
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0168 0.516
Echinococcus granulosus survival motor neuron protein 1 0.0204 0.1124 0.1124
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0042 0.0042
Loa Loa (eye worm) AGC/AKT protein kinase 0.0019 0.003 0.003
Schistosoma mansoni lamin 0.0023 0.0057 0.0057
Schistosoma mansoni serine/threonine protein kinase 0.0072 0.0343 0.0343
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0019 0.003 0.003
Schistosoma mansoni thyroid hormone receptor 0.0149 0.0803 0.0803
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0042 0.0042
Echinococcus multilocularis ATP synthase subunit alpha, mitochondrial 0.0047 0.0198 0.0198
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0319 1
Schistosoma mansoni hypothetical protein 0.0026 0.0071 0.0071
Onchocerca volvulus ATP synthase subunit alpha, mitochondrial homolog 0.0047 0.0198 0.1727
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0148 0.0793 0.0793
Wolbachia endosymbiont of Brugia malayi ATP synthase F0F1 subunit alpha 0.0047 0.0198 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.0071 0.0071
Onchocerca volvulus 0.0134 0.0715 0.6332
Trypanosoma brucei unspecified product 0.0035 0.0128 0.3879
Echinococcus multilocularis dna polymerase kappa 0.0042 0.0168 0.0168
Echinococcus multilocularis protein kinase c epsilon type 0.0033 0.0116 0.0116
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0168 0.516
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0019 0.003 0.003
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0033 0.0033
Schistosoma mansoni intermediate filament proteins 0.0023 0.0057 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0042 0.0042
Entamoeba histolytica protein kinase, putative 0.0019 0.003 0.0942
Schistosoma mansoni ap endonuclease 0.0019 0.0033 0.0033
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0019 0.003 0.003
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0105 0.0539 0.0539
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0042 0.0042
Schistosoma mansoni coup transcription factor 0.0021 0.0042 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.002 0.0408
Echinococcus multilocularis ATP synthase subunit beta, mitochondrial 0.0043 0.0173 0.0173
Plasmodium vivax ATP synthase subunit beta, mitochondrial, putative 0.0043 0.0173 0.8412
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0042 0.0042
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0033 0.0861
Onchocerca volvulus 0.0204 0.1126 1
Echinococcus multilocularis geminin 0.0276 0.155 0.155
Brugia malayi steroid hormone receptor 0.0021 0.0042 0.0042
Echinococcus multilocularis serine:threonine protein kinase 38 0.0019 0.003 0.003
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0061 0.166
Trichomonas vaginalis AGC family protein kinase 0.0019 0.003 0.0267
Treponema pallidum V-type ATP synthase subunit A 0.0024 0.0061 0.1654
Schistosoma mansoni ubiquitin ligase sina (ec 6.3.2.-) (seven in absentia homolog)(smsina) 0.1704 1 1
Brugia malayi hypothetical protein 0.0123 0.0645 0.0645
Echinococcus granulosus dna polymerase eta 0.0015 0.0007 0.0007
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0072 0.0343 0.0343
Trypanosoma brucei rac serine-threonine kinase, putative 0.0019 0.003 0.0747
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0042 0.0042
Brugia malayi ATP synthase alpha chain, mitochondrial precursor, putative 0.0047 0.0198 0.0198
Schistosoma mansoni protein kinase C 0.0014 0.0005 0.0005
Onchocerca volvulus 0.0042 0.0165 0.1428
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0042 0.0042
Echinococcus multilocularis lamin 0.0023 0.0057 0.0057
Brugia malayi MH2 domain containing protein 0.0103 0.0527 0.0527
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0123 0.0645 0.0645
Trichomonas vaginalis DNA polymerase eta, putative 0.0042 0.0168 0.1489
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0085 0.0422 0.0422
Schistosoma mansoni survival motor neuron protein 0.0042 0.0165 0.0165
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0047 0.128
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0081 0.0399 0.0399
Entamoeba histolytica protein kinase, putative 0.0019 0.003 0.0942
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0033 0.1034
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0042 0.0042
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0319 0.0319
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0026 0.0071 0.0071
Schistosoma mansoni hypothetical protein 0.0026 0.0071 0.0071
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0047 0.128
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0168 0.8142
Entamoeba histolytica V-type ATPase, A subunit, putative 0.0024 0.0061 0.19
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0023 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0042 0.0165 0.0165
Echinococcus multilocularis serine threonine protein kinase 0.0058 0.0265 0.0265
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0168 0.516
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0033 0.0841
Echinococcus multilocularis GPCR, family 2 0.0026 0.0071 0.0071
Entamoeba histolytica hypothetical protein 0.0059 0.0266 0.8335
Echinococcus multilocularis musashi 0.0023 0.0057 0.0057
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.0071 0.0071
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0168 0.516
Brugia malayi Pre-SET motif family protein 0.0179 0.0979 0.0979
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0319 0.0319
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0129 0.0681 0.0681
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0061 0.1011
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0134 0.0715 0.0715
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0042
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0042 0.0327
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.007 0.0332 0.2953
Plasmodium falciparum ATP synthase subunit beta, mitochondrial 0.0043 0.0173 0.8412
Schistosoma mansoni hypothetical protein 0.0042 0.0165 0.0165
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0018 0.0028 0.0245
Entamoeba histolytica protein kinase, putative 0.0019 0.003 0.0942
Schistosoma mansoni lamin 0.0023 0.0057 0.0057
Brugia malayi Calcitonin receptor-like protein seb-1 0.0081 0.0399 0.0399
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0081 0.0399 0.0399
Loa Loa (eye worm) ATP synthase subunit beta 0.0029 0.0093 0.0093
Trypanosoma cruzi Vacuolar proton pump subunit B, putative 0.0047 0.02 0.6191
Loa Loa (eye worm) hypothetical protein 0.0153 0.0826 0.0826
Mycobacterium ulcerans F0F1 ATP synthase subunit alpha 0.0047 0.0198 1
Brugia malayi Intermediate filament tail domain containing protein 0.0023 0.0057 0.0057
Loa Loa (eye worm) MH2 domain-containing protein 0.0103 0.0527 0.0527
Plasmodium falciparum ATP synthase F1, alpha subunit 0.0047 0.0198 0.9913
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0204 0.1124 0.1124
Trypanosoma cruzi ATP synthase subunit beta, mitochondrial, putative 0.0043 0.0173 0.5342
Schistosoma mansoni ATP synthase alpha subunit mitochondrial 0.0047 0.0198 0.0198
Leishmania major ATPase beta subunit, putative 0.0043 0.0173 0.5342
Echinococcus multilocularis vacuolar ATP synthase subunit b 0.0047 0.02 0.02
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.003 0.003
Trichomonas vaginalis AGC family protein kinase 0.0019 0.003 0.0267
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0042 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0042 0.0042
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0168 0.516
Echinococcus granulosus Protein kinase C brain isozyme 0.0072 0.0343 0.0343
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0042 0.0042
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0319 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0042 0.0042
Echinococcus granulosus lamin 0.0023 0.0057 0.0057
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0019 0.003 0.003
Onchocerca volvulus 0.0085 0.0422 0.3724
Echinococcus multilocularis e3 ubiquitin protein ligase siah1 0.1704 1 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0319 0.0319
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0107 0.3223
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0026 0.0071 0.0071
Schistosoma mansoni unc-13 (munc13) 0.0014 0.0005 0.0005
Schistosoma mansoni ATP synthase alpha subunit vacuolar 0.0024 0.0061 0.0061
Schistosoma mansoni hypothetical protein 0.0055 0.0247 0.0247
Echinococcus multilocularis dna polymerase eta 0.0015 0.0007 0.0007
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0015 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0276 0.155 0.155
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0019 0.003 0.003
Brugia malayi nuclear receptor NHR-88 0.0021 0.0042 0.0042
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0033 0.0116 0.0116
Treponema pallidum V-type ATP synthase subunit A 0.0024 0.0061 0.1654
Schistosoma mansoni ap endonuclease 0.0019 0.0033 0.0033
Trypanosoma brucei DNA polymerase IV, putative 0.0035 0.0128 0.3879
Onchocerca volvulus 0.0021 0.0042 0.0327
Trichomonas vaginalis ATP synthase beta subunit, putative 0.0024 0.0061 0.0538
Trichomonas vaginalis set domain proteins, putative 0.0204 0.1126 1
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0042
Schistosoma mansoni ATP synthase beta subunit 0.0043 0.0173 0.0173
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0168 0.516
Echinococcus granulosus protein kinase C gamma type 0.0058 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0055 0.0247 0.0247
Giardia lamblia Vacuolar ATP synthase subunit B 0.0047 0.02 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0015 0.0007 0.0007
Echinococcus multilocularis survival motor neuron protein 1 0.0204 0.1124 0.1124
Onchocerca volvulus 0.0123 0.0648 0.5738
Toxoplasma gondii melibiase subfamily protein 0.0105 0.0539 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0042 0.0042
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0014 0.0005 0.0005
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0042 0.0042
Brugia malayi Melibiase family protein 0.007 0.0332 0.0332
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0026 0.0071 0.0071
Loa Loa (eye worm) AGC/PKN protein kinase 0.0019 0.003 0.003
Mycobacterium leprae PROBABLE ATP SYNTHASE ALPHA CHAIN ATPA 0.0047 0.0198 0.5498
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0026 0.0071 0.0071
Entamoeba histolytica protein kinase, putative 0.0019 0.003 0.0942
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0033 0.0293
Loa Loa (eye worm) hypothetical protein 0.007 0.0332 0.0332
Schistosoma mansoni DNA polymerase eta 0.0015 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0042 0.0042
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0019 0.003 0.003
Mycobacterium tuberculosis Probable ATP synthase alpha chain AtpA 0.0047 0.0198 0.6295
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0061 0.1674
Schistosoma mansoni unc-13 (munc13) 0.0016 0.0014 0.0014
Brugia malayi latrophilin 2 splice variant baaae 0.0055 0.0247 0.0247
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0042 0.0042
Leishmania major vacuolar ATP synthase catalytic subunit A, putative 0.0024 0.0061 0.1726
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0033 0.0841
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0042 0.0042
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.0071 0.0071
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0061 0.0007
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0042 0.0042
Brugia malayi Protein kinase domain containing protein 0.0019 0.003 0.003
Giardia lamblia DINP protein human, muc B family 0.0022 0.0047 0.0821
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0019 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0042
Echinococcus granulosus ATPase H transporting lysosomal accessory 0.0123 0.0645 0.0645
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0085 0.0422 0.0422
Schistosoma mansoni serine/threonine protein kinase 0.0072 0.0343 0.0343
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0042
Trichomonas vaginalis AGC family protein kinase 0.0019 0.003 0.0267
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0042 0.0042
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.003 0.003
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0026 0.0071 0.121
Echinococcus granulosus e3 ubiquitin protein ligase siah1 0.1704 1 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0123 0.0648 0.0648
Mycobacterium ulcerans F0F1 ATP synthase subunit beta 0.0043 0.0173 0.8486
Echinococcus granulosus histone lysine methyltransferase setb 0.0026 0.0071 0.0071
Echinococcus multilocularis serine:threonine protein kinase N2 0.0019 0.003 0.003
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0042 0.0327
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0042 0.0042
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0026 0.0071 0.0071
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0061 0.1011
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0042 0.0042
Schistosoma mansoni ATP synthase subunit beta vacuolar 0.0047 0.02 0.02
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0026 0.0071 0.0071
Schistosoma mansoni hypothetical protein 0.0276 0.155 0.155
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0105 0.0539 0.0539
Entamoeba histolytica hypothetical protein 0.0059 0.0266 0.8335
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0042 0.0042
Trypanosoma brucei V-type ATPase, A subunit, putative 0.0024 0.0061 0.1726
Echinococcus multilocularis lamin dm0 0.0023 0.0057 0.0057
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0047 0.1311
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0129 0.0681 0.0681
Trypanosoma brucei ATP synthase subunit beta, mitochondrial 0.0043 0.0173 0.5342
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0042
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0042 0.0042
Echinococcus granulosus L aminoadipate semialdehyde 0.0085 0.0422 0.0422
Brugia malayi Protein kinase domain containing protein 0.0019 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.1704 1 1
Echinococcus granulosus dna polymerase kappa 0.0042 0.0168 0.0168
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0025 0.0066 0.0066
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0319 1
Chlamydia trachomatis type III secretion system ATPase 0.0043 0.0173 0.8097
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0015 0.0007 0.0007
Echinococcus multilocularis protein kinase c iota type 0.0032 0.0108 0.0108
Brugia malayi Pre-SET motif family protein 0.0026 0.0071 0.0071
Entamoeba histolytica V-type ATPase, B subunit, putative 0.0047 0.02 0.6272
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0033 0.0841
Echinococcus multilocularis serine:threonine protein kinase N2 0.0019 0.003 0.003
Loa Loa (eye worm) transcription factor SMAD2 0.0103 0.0527 0.0527
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.002 0.0408
Plasmodium vivax SET domain protein, putative 0.0026 0.0071 0.2294
Loa Loa (eye worm) hypothetical protein 0.0023 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0042
Trypanosoma cruzi V-type proton ATPase subunit B, putative 0.0047 0.02 0.6191
Plasmodium vivax ATP synthase alpha chain, putative 0.0047 0.0198 0.9913
Wolbachia endosymbiont of Brugia malayi ATP synthase F0F1 subunit beta 0.0043 0.0173 0.8486
Loa Loa (eye worm) intermediate filament protein 0.0023 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0134 0.0715 0.0715
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0168 0.516
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0061 0.1729
Trichomonas vaginalis AGC family protein kinase 0.0019 0.003 0.0267
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0061 0.166
Brugia malayi intermediate filament protein 0.0023 0.0057 0.0057
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0033 0.0293
Toxoplasma gondii ATP synthase beta subunit ATP-B 0.0043 0.0173 0.3128
Brugia malayi nuclear hormone receptor 0.0021 0.0042 0.0042
Loa Loa (eye worm) latrophilin receptor protein 2 0.0026 0.0071 0.0071
Trypanosoma brucei ATP synthase F1, alpha subunit 0.0034 0.0118 0.3552
Trichomonas vaginalis ATP synthase alpha subunit mitochondrial, putative 0.0047 0.02 0.1775
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0026 0.0071 0.0071
Brugia malayi Protein kinase c protein 2 0.0053 0.0235 0.0235
Entamoeba histolytica hypothetical protein 0.0059 0.0266 0.8335
Echinococcus granulosus geminin 0.0276 0.155 0.155
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0179 0.0979 0.0979
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0019 0.003 0.003
Mycobacterium tuberculosis Probable ATP synthase beta chain AtpD 0.0066 0.0311 1
Echinococcus granulosus NDR protein kinase 0.0019 0.003 0.003
Echinococcus granulosus RNA directed DNA polymerase 0.0038 0.0146 0.0146
Leishmania major vacuolar ATP synthase subunit b, putative 0.0047 0.02 0.6191
Echinococcus granulosus protein kinase c epsilon type 0.0033 0.0116 0.0116
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0107 0.3223
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0042 0.0042
Schistosoma mansoni hypothetical protein 0.0026 0.0071 0.0071
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0105 0.0539 0.0539
Plasmodium vivax vacuolar ATP synthase catalytic subunit A, putative 0.0024 0.0061 0.1654
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0042 0.0042
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0042 0.0042
Brugia malayi polk-prov protein 0.0032 0.0107 0.0107
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0105 0.0539 0.0539
Echinococcus multilocularis thyroid hormone receptor alpha 0.0149 0.0803 0.0803
Plasmodium falciparum V-type proton ATPase subunit B 0.0047 0.02 1
Trichomonas vaginalis AGC family protein kinase 0.0019 0.003 0.0267
Trichomonas vaginalis AGC family protein kinase 0.0019 0.003 0.0267
Brugia malayi Protein kinase domain containing protein 0.0019 0.003 0.003
Leishmania major ATPase beta subunit, putative 0.0043 0.0173 0.5342
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0007 0.0007
Brugia malayi ecdysteroid receptor 0.0021 0.0042 0.0042
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.004 0.0156 0.0156
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0061 0.1674
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.003 0.003
Leishmania major ATPase alpha subunit 0.0034 0.0118 0.3552
Echinococcus granulosus vacuolar ATP synthase subunit b 0.0047 0.02 0.02
Brugia malayi protein kinase C II. 0.0033 0.0116 0.0116
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0015 0.0007 0.0007
Brugia malayi vacuolar ATP synthase catalytic subunit A, osteoclast isoform 0.0024 0.0061 0.0061
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0319 0.0319
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0105 0.0539 0.0539
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0168 0.516
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0319 1
Echinococcus multilocularis vacuolar H+ ATPase v1 sector subunit A 0.0024 0.0061 0.0061
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0061 0.166
Plasmodium falciparum V-type proton ATPase catalytic subunit A 0.0024 0.0061 0.1654
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0026 0.0071 0.0071
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0042 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0168 0.516
Loa Loa (eye worm) hypothetical protein 0.0052 0.0225 0.0225
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0042 0.0042
Schistosoma mansoni thyroid hormone receptor 0.0149 0.0803 0.0803
Toxoplasma gondii AGC kinase 0.0019 0.003 0.0435
Loa Loa (eye worm) hypothetical protein 0.0038 0.0146 0.0146
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.007 0.0332 0.0332
Schistosoma mansoni hypothetical protein 0.0026 0.0071 0.0071
Echinococcus granulosus protein kinase c iota type 0.0032 0.0108 0.0108
Toxoplasma gondii vacuolar ATP synthase subunit A, putative 0.0024 0.0061 0.1009

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.