Detailed information for compound 1851916

Basic information

Technical information
  • TDR Targets ID: 1851916
  • Name: tert-butyl N-[(2S)-1-[[(2S)-1-[[(4S,5R,6R,7R) -5,6-dihydroxy-2,8-dimethyl-7-[[(2S)-2-methyl butyl]carbamoyl]nonan-4-yl]amino]-3-(3H-imida zol-4-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phe nylpropan-2-yl]carbamate
  • MW: 700.908 | Formula: C37H60N6O7
  • H donors: 7 H acceptors: 7 LogP: 4.6 Rotable bonds: 25
    Rule of 5 violations (Lipinski): 3
  • SMILES: CC[C@@H](CNC(=O)[C@@H]([C@H]([C@@H]([C@@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)CC(C)C)O)O)C(C)C)C
  • InChi: 1S/C37H60N6O7/c1-10-24(6)19-39-35(48)30(23(4)5)32(45)31(44)27(16-22(2)3)41-34(47)29(18-26-20-38-21-40-26)42-33(46)28(17-25-14-12-11-13-15-25)43-36(49)50-37(7,8)9/h11-15,20-24,27-32,44-45H,10,16-19H2,1-9H3,(H,38,40)(H,39,48)(H,41,47)(H,42,46)(H,43,49)/t24-,27-,28-,29-,30+,31+,32+/m0/s1
  • InChiKey: PIKMEJCYGLUULJ-YHCBXFNRSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • tert-butyl N-[(1S)-2-[[(1S)-2-[[(1S,2R,3R,4R)-2,3-dihydroxy-1-isobutyl-5-methyl-4-[[(2S)-2-methylbutyl]carbamoyl]hexyl]amino]-1-(3H-imidazol-4-ylmethyl)-2-oxo-ethyl]amino]-2-oxo-1-(phenylmethyl)ethyl]carbamate
  • N-[(1S)-2-[[(1S)-2-[[(1S,2R,3R,4R)-2,3-dihydroxy-1-isobutyl-5-methyl-4-[[[(2S)-2-methylbutyl]amino]-oxomethyl]hexyl]amino]-1-(3H-imidazol-4-ylmethyl)-2-oxoethyl]amino]-2-oxo-1-(phenylmethyl)ethyl]carbamic acid tert-butyl ester
  • N-[(1S)-1-(benzyl)-2-[[(1S)-2-[[(1S,2R,3R,4R)-2,3-dihydroxy-1-isobutyl-5-methyl-4-[[(2S)-2-methylbutyl]carbamoyl]hexyl]amino]-1-(3H-imidazol-4-ylmethyl)-2-keto-ethyl]amino]-2-keto-ethyl]carbamic acid tert-butyl ester
  • tert-butyl N-[(2S)-1-[[(2S)-1-[[(4S,5R,6R,7R)-5,6-dihydroxy-2,8-dimethyl-7-[[(2S)-2-methylbutyl]carbamoyl]nonan-4-yl]amino]-3-(3H-imidazol-4-yl)-1-oxo-propan-2-yl]amino]-1-oxo-3-phenyl-propan-2-yl]carbamate
  • 107600-10-2
  • L-Histidinamide, N-((1,1-dimethylethoxy)carbonyl)-L-phenylalanyl-N-(2,3-dihydroxy-5-methyl-4-(((2-methylbutyl)amino)carbonyl)-1-(2-methylpropyl)hexyl)-, (1S-(1R*,2S*,3S*,4S*(R*)))-
  • AIDS-027576
  • AIDS027576
  • L-Histidinamide, N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl-N-[2,3-dihydroxy-5-methyl-4-[[(2-methylbutyl)amino]carbonyl]-1-(2-methylpropyl)hexyl]-, [1S-[1R*,2S*,3S*,4S*(R*)]]-

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens renin Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Cathepsin D precursor, putative Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma mansoni cathepsin D (A01 family) Get druggable targets OG5_126885 All targets in OG5_126885
Candida albicans vacuolar aspartic proteinase precursor similar to S. cerevisiae PEP4 (YPL154C) Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium yoelii hypothetical protein Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium berghei plasmepsin VI Get druggable targets OG5_126885 All targets in OG5_126885
Candida albicans vacuolar aspartic proteinase precursor similar to S. cerevisiae PEP4 (YPL154C) Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium knowlesi plasmepsin IV, putative Get druggable targets OG5_126885 All targets in OG5_126885
Neospora caninum Pepsinogen A1, related Get druggable targets OG5_126885 All targets in OG5_126885
Cryptosporidium parvum membrane bound aspartyl proteinase with a signal peptide plus transmembrane domain Get druggable targets OG5_126885 All targets in OG5_126885
Toxoplasma gondii aspartyl proteinase (eimepsin), putative Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium falciparum plasmepsin II Get druggable targets OG5_126885 All targets in OG5_126885
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium falciparum plasmepsin VI Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium yoelii hypothetical protein Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium vivax aspartyl proteinase, putative Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium vivax plasmepsin IV, putative Get druggable targets OG5_126885 All targets in OG5_126885
Toxoplasma gondii aspartyl protease ASP1 Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma japonicum ko:K01379 cathepsin D [EC3.4.23.5], putative Get druggable targets OG5_126885 All targets in OG5_126885
Loa Loa (eye worm) aspartic protease BmAsp-2 Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium falciparum plasmepsin I Get druggable targets OG5_126885 All targets in OG5_126885
Cryptosporidium hominis aspartyl protease precursor Get druggable targets OG5_126885 All targets in OG5_126885
Babesia bovis eukaryotic aspartyl protease family protein Get druggable targets OG5_126885 All targets in OG5_126885
Echinococcus granulosus cathepsin d lysosomal aspartyl protease Get druggable targets OG5_126885 All targets in OG5_126885
Theileria parva pepsinogen, putative Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium yoelii plasmepsin Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium falciparum plasmepsin IV Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium knowlesi aspartyl protease, putative Get druggable targets OG5_126885 All targets in OG5_126885
Theileria parva cathepsin E, putative Get druggable targets OG5_126885 All targets in OG5_126885
Neospora caninum Renin, related Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium berghei plasmepsin IV Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma mansoni cathepsin D (A01 family) Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) Get druggable targets OG5_126885 All targets in OG5_126885
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) Get druggable targets OG5_126885 All targets in OG5_126885
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase Get druggable targets OG5_126885 All targets in OG5_126885
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum plasmepsin X renin 406 aa 352 aa 26.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi FAD binding domain containing protein 0.0798 0.0845 0.0876
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.2922 0.3673 1
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.2922 0.3673 1
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.7671 1 1
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.1039 0.1166 0.1065
Schistosoma mansoni aspartate carbamoyltransferase 0.066 0.0661 0.0661
Brugia malayi flavodoxin family protein 0.0305 0.0188 0.0195
Toxoplasma gondii carbamoylphosphate synthetase 0.066 0.0661 0.0529
Loa Loa (eye worm) integrin beta-2 0.0337 0.023 0.0116
Treponema pallidum flavodoxin 0.0305 0.0188 1
Trypanosoma cruzi glutamine-dependent carbamoyl-phosphate synthetase, putative 0.066 0.0661 0.0874
Brugia malayi Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor 0.0269 0.0139 0.0144
Entamoeba histolytica acetyl-coA carboxylase, putative 0.1308 0.1524 1
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0269 0.0139 0.0139
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.1039 0.1166 0.2905
Toxoplasma gondii flavodoxin domain-containing protein 0.0396 0.0309 0.0172
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0305 0.0188 0.0082
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0798 0.0845 0.0715
Schistosoma mansoni cathepsin D (A01 family) 0.0174 0.0013 0.0013
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.066 0.0661 0.1476
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.2922 0.3673 0.3584
Echinococcus granulosus dihydrolipoyllysine residue acetyltransferase 0.0269 0.0139 0.0026
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0798 0.0845 0.1182
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.7402 0.9642 1
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.2922 0.3673 1
Leishmania major carbamoyl-phosphate synthase, putative 0.066 0.0661 0.0529
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.5551 0.7176 1
Brugia malayi flavodoxin family protein 0.0798 0.0845 0.0876
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.1039 0.1166 0.2905
Echinococcus multilocularis Biotin lipoyl attachment 0.0269 0.0139 0.0026
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.1039 0.1166 0.2905
Brugia malayi FAD binding domain containing protein 0.0493 0.0438 0.0454
Schistosoma mansoni integrin beta subunit 0.0198 0.0045 0.0045
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.2922 0.3673 1
Trypanosoma brucei unspecified product 0.1921 0.234 0.2232
Schistosoma mansoni NADPH flavin oxidoreductase 0.0402 0.0317 0.0317
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.1039 0.1166 0.1166
Plasmodium falciparum carbamoyl phosphate synthetase 0.066 0.0661 0.0742
Trypanosoma brucei glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative 0.066 0.0661 0.0529
Loa Loa (eye worm) hypothetical protein 0.0269 0.0139 0.0021
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.1039 0.1166 0.2905
Plasmodium vivax hypothetical protein, conserved 0.0305 0.0188 0.0069
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0798 0.0845 0.0715
Schistosoma mansoni dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase 0.0269 0.0139 0.0139
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.1039 0.1166 0.2905
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0708 0.0724 0.8159
Trypanosoma cruzi glutamine dependent carbamoyl-phosphate synthase, putative 0.066 0.0661 0.0874
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0798 0.0845 0.1182
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0798 0.0845 0.074
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0798 0.0845 0.1003
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.2922 0.3673 0.3584
Loa Loa (eye worm) hypothetical protein 0.0798 0.0845 0.0762
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.1039 0.1166 0.1041
Echinococcus granulosus methionine synthase reductase 0.0493 0.0438 0.0328
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0305 0.0188 0.0082
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.2922 0.3673 0.3584
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0798 0.0845 0.1996
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.1039 0.1166 0.3233
Schistosoma mansoni dihydrolipoamide S-acetyltransferase 0.0269 0.0139 0.0139
Echinococcus granulosus dihydrolipoyllysine residue succinyltransferase 0.0269 0.0139 0.0026
Leishmania major hypothetical protein, conserved 0.0305 0.0188 0.005
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.1308 0.1524 1
Trypanosoma brucei acetyl-CoA carboxylase 0.7671 1 1
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0798 0.0845 0.0715
Chlamydia trachomatis biotin carboxylase 0.2653 0.3316 1
Schistosoma mansoni carbamoyl-phosphate synthetase 0.066 0.0661 0.0661
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.0305 0.0188 0.0082
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.1039 0.1166 0.2905
Echinococcus multilocularis dihydrolipoyllysine residue succinyltransferase 0.0269 0.0139 0.0026
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.1039 0.1166 0.172
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.2922 0.3673 1
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.1039 0.1166 0.2905
Echinococcus multilocularis methionine synthase reductase 0.0493 0.0438 0.0328
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0798 0.0845 0.0715
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.2922 0.3673 0.3601
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.7671 1 1
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.1039 0.1166 0.2905
Leishmania major p450 reductase, putative 0.0798 0.0845 0.0715
Schistosoma mansoni diflavin oxidoreductase 0.0396 0.0309 0.0309
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.2922 0.3673 1
Echinococcus granulosus Biotin lipoyl attachment 0.0269 0.0139 0.0026
Toxoplasma gondii pyruvate carboxylase 0.2922 0.3673 0.3584
Toxoplasma gondii flavodoxin domain-containing protein 0.0396 0.0309 0.0172
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.1039 0.1166 0.1041
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.5551 0.7176 1
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.1039 0.1166 0.1041
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0798 0.0845 0.0715
Brugia malayi dihydrolipoamide S-acetyltransferase precursor, putative 0.0269 0.0139 0.0144
Schistosoma mansoni cytochrome P450 reductase 0.0798 0.0845 0.0845
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.066 0.0661 0.1476
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0798 0.0845 0.074
Schistosoma mansoni acetyl-CoA carboxylase 0.7671 1 1
Schistosoma mansoni pyruvate carboxylase 0.2922 0.3673 0.3673
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.2922 0.3673 0.3673
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.2922 0.3673 1
Trypanosoma cruzi acetyl-CoA carboxylase 0.4749 0.6108 1
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0278 0.0151 0.0151
Leishmania major propionyl-coa carboxylase beta chain, putative 0.1039 0.1166 0.1041
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0269 0.0139 0.0139
Trichomonas vaginalis sulfite reductase, putative 0.0798 0.0845 1
Echinococcus multilocularis dihydrolipoyllysine residue acetyltransferase 0.0269 0.0139 0.0026
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.1039 0.1166 0.2905
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.2922 0.3673 0.3601
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.1039 0.1166 0.1065
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.1039 0.1166 0.2905
Schistosoma mansoni carbamoyl-phosphate synthetase 0.066 0.0661 0.0661
Loa Loa (eye worm) FAD binding domain-containing protein 0.0493 0.0438 0.0335
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0305 0.0188 0.0069
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.0305 0.0188 0.0069
Leishmania major carboxylase, putative 0.2922 0.3673 0.3584
Schistosoma mansoni cathepsin D (A01 family) 0.0174 0.0013 0.0013
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.066 0.0661 0.0742
Brugia malayi Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta 0.0269 0.0139 0.0144
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.2922 0.3673 0.5922
Plasmodium vivax flavodoxin domain containing protein 0.0708 0.0724 0.0831
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0798 0.0845 0.1182
Brugia malayi Integrin beta pat-3 precursor 0.0337 0.023 0.0238
Leishmania major cytochrome P450 reductase, putative 0.0708 0.0724 0.0593
Brugia malayi Carboxyl transferase domain containing protein 0.7402 0.9642 1
Trypanosoma cruzi p450 reductase, putative 0.0798 0.0845 0.1182
Plasmodium falciparum nitric oxide synthase, putative 0.0798 0.0845 0.1003
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.2922 0.3673 0.5922
Loa Loa (eye worm) flavodoxin family protein 0.0305 0.0188 0.0073
Leishmania major acetyl-CoA carboxylase, putative 0.7671 1 1
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.7671 1 1
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.1039 0.1166 0.172
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0493 0.0438 0.0438
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.1039 0.1166 0.2905
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.2922 0.3673 0.3673
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.1039 0.1166 0.172
Loa Loa (eye worm) hypothetical protein 0.0269 0.0139 0.0021
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0798 0.0845 0.074
Loa Loa (eye worm) FAD binding domain-containing protein 0.0798 0.0845 0.0762
Mycobacterium ulcerans pyruvate carboxylase 0.2922 0.3673 1
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0305 0.0188 0.005
Loa Loa (eye worm) hypothetical protein 0.0269 0.0139 0.0021
Chlamydia trachomatis sulfite reductase 0.0493 0.0438 0.094
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0798 0.0845 0.074
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.1039 0.1166 0.2905
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1528 0.1816 0.1816

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 3.4 uM Tested for the inhibition of human plasma renin ChEMBL. 3295239

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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