Detailed information for compound 1864855

Basic information

Technical information
  • TDR Targets ID: 1864855
  • Name: (3-acetamidoacridin-9-yl)-[4-(hexylsulfonylam ino)phenyl]azanium; methanesulfonate
  • MW: 586.723 | Formula: C28H34N4O6S2
  • H donors: 4 H acceptors: 7 LogP: 4.66 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: [O-]S(=O)(=O)C.CCCCCCS(=O)(=O)Nc1ccc(cc1)Nc1c2ccccc2[nH+]c2c1ccc(c2)NC(=O)C
  • InChi: 1S/C27H30N4O3S.CH4O3S/c1-3-4-5-8-17-35(33,34)31-21-13-11-20(12-14-21)29-27-23-9-6-7-10-25(23)30-26-18-22(28-19(2)32)15-16-24(26)27;1-5(2,3)4/h6-7,9-16,18,31H,3-5,8,17H2,1-2H3,(H,28,32)(H,29,30);1H3,(H,2,3,4)
  • InChiKey: QGGUOGWJVQPOFV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3-acetamidoacridin-9-yl)-[4-(hexylsulfonylamino)phenyl]ammonium; methanesulfonate
  • (3-acetamido-9-acridinyl)-[4-(hexylsulfonylamino)phenyl]ammonium; methanesulfonate
  • 53222-06-3
  • ACETAMIDE, N-(9-(4-(HEXYLSULFONAMIDO)ANILINO)ACRIDIN-3-YL)-, METHANESULFONATE
  • N-(9-(4-(Hexylsulfonamido)anilino)acridin-3-yl)acetamide methanesulfonate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0316 0.9667 1
Giardia lamblia Phosphoglycerate kinase 0.0184 0.5493 0.5645
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0184 0.5493 1
Trypanosoma brucei chrX additional, unordered contigs 0.0013 0.0083 0.0062
Brugia malayi regulator of G-protein signaling rgs-7 0.0014 0.0111 0.0119
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0154 0.4561 0.4549
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0033 0.0722 0.1181
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0046 0.1126 0.1107
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0993 0.0974
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.184 0.2037
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.184 0.2037
Loa Loa (eye worm) DnaJ domain-containing protein 0.0066 0.1768 0.1957
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0154 0.4555 0.5004
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0083 0.0062
Echinococcus granulosus tar DNA binding protein 0.0068 0.184 0.3345
Echinococcus multilocularis expressed protein 0.0036 0.0816 0.148
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0694 0.0767
Loa Loa (eye worm) RNA binding protein 0.0068 0.184 0.2037
Echinococcus multilocularis axis inhibition protein axin 0.0014 0.0111 0.0196
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0694 0.1264
Echinococcus granulosus axis inhibition protein axin 0.0014 0.0111 0.0196
Trichomonas vaginalis rotamase, putative 0.0036 0.0816 0.0738
Brugia malayi RNA binding protein 0.0068 0.184 0.2037
Echinococcus granulosus muscleblind protein 0.0161 0.4781 0.8704
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0121 0.0131
Schistosoma mansoni regulator of G protein signaling 0.0014 0.0111 0.0119
Echinococcus granulosus regulator of G protein signaling 3 0.0014 0.0111 0.0196
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0326 1 1
Schistosoma mansoni rotamase 0.0036 0.0816 0.0901
Schistosoma mansoni DNA polymerase IV / kappa 0.0013 0.0083 0.0089
Chlamydia trachomatis phosphoglycerate kinase 0.0184 0.5493 0.5
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0694 0.1259
Loa Loa (eye worm) hypothetical protein 0.0014 0.0111 0.0119
Brugia malayi Glycosyl hydrolases family 31 protein 0.0015 0.0134 0.0145
Leishmania major phosphoglycerate kinase B, cytosolic 0.0184 0.5493 0.5483
Schistosoma mansoni z-protein (S1r protein) 0.0014 0.0111 0.0119
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0184 0.5493 0.5483
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0314 0.0426
Echinococcus multilocularis phosphoglycerate kinase 1 0.0184 0.5493 1
Brugia malayi Phosphoglycerate kinase 0.0067 0.181 0.2004
Entamoeba histolytica hypothetical protein 0.0014 0.0111 0.0115
Giardia lamblia Fructose-bisphosphate aldolase 0.0316 0.9667 1
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0993 0.1018
Trichomonas vaginalis maltase-glucoamylase, putative 0.0015 0.0134 0.0025
Mycobacterium ulcerans hypothetical protein 0.0172 0.5113 0.5628
Echinococcus multilocularis lysosomal alpha glucosidase 0.0176 0.5244 0.9547
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0037 0.0847 0.0827
Trichomonas vaginalis protein kinase inhibitor, putative 0.0066 0.1768 0.1734
Mycobacterium ulcerans glutaminase 0.0295 0.902 1
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0067 0.181 0.1793
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0083 0.0062
Echinococcus multilocularis regulator of G protein signaling 3 0.0014 0.0111 0.0196
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0014 0.0111 0.0119
Leishmania major DNA polymerase eta, putative 0.004 0.0954 0.0935
Echinococcus multilocularis muscleblind protein 1 0.0161 0.4781 0.8704
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0067 0.181 0.1793
Trypanosoma brucei unspecified product 0.0042 0.0993 0.0974
Echinococcus granulosus bloom syndrome protein 0.0049 0.1224 0.2224
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0184 0.5493 0.5632
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0326 1 1
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0138 0.4054 0.4492
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0037 0.0847 0.0827
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0037 0.0847 0.1411
Echinococcus granulosus expressed protein 0.0014 0.0111 0.0196
Schistosoma mansoni alpha-glucosidase 0.0151 0.4469 0.4952
Schistosoma mansoni axis inhibition protein axin 0.0014 0.0111 0.0119
Schistosoma mansoni DNA helicase recq1 0.002 0.0314 0.0345
Onchocerca volvulus 0.0032 0.0694 0.089
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.091 0.0836
Echinococcus multilocularis Regulator of G protein signaling 20 0.0014 0.0111 0.0196
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.091 0.0836
Loa Loa (eye worm) hypothetical protein 0.0032 0.0694 0.0767
Treponema pallidum fructose-bisphosphate aldolase 0.0316 0.9667 1
Echinococcus multilocularis axis inhibition protein axin 0.0014 0.0111 0.0196
Plasmodium vivax SET domain protein, putative 0.0032 0.0694 0.113
Schistosoma mansoni tar DNA-binding protein 0.0068 0.184 0.2037
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0011 0.0021 0.0038
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0316 0.9667 1
Echinococcus granulosus regulator of G protein signaling 7 0.0014 0.0111 0.0196
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0125 0.3617 0.4007
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.091 0.1006
Schistosoma mansoni tar DNA-binding protein 0.0068 0.184 0.2037
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.091 0.1656
Toxoplasma gondii Erv1 / Alr family protein 0.0037 0.0847 0.1541
Schistosoma mansoni tar DNA-binding protein 0.0068 0.184 0.2037
Leishmania major DNA polymerase eta, putative 0.0069 0.1864 0.1847
Trichomonas vaginalis glutaminase, putative 0.0295 0.902 0.9323
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0316 0.9667 1
Leishmania major phosphoglycerate kinase C, glycosomal 0.0184 0.5493 0.5483
Loa Loa (eye worm) glutaminase 2 0.0295 0.902 1
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0067 0.181 0.1793
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0042 0.0993 0.1098
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0083 0.0062
Trichomonas vaginalis DNA helicase recq1, putative 0.0049 0.1224 0.1165
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.091 0.0941
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.091 0.0891
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0584 0.0564
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0035 0.0789 0.077
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0184 0.5493 1
Schistosoma mansoni axis inhibition protein axin 0.0014 0.0111 0.0119
Echinococcus multilocularis regulator of G protein signaling 7 0.0014 0.0111 0.0196
Schistosoma mansoni regulator of G protein signaling 0.0014 0.0111 0.0119
Schistosoma mansoni blooms syndrome DNA helicase 0.0039 0.0898 0.0992
Schistosoma mansoni hypothetical protein 0.0066 0.1768 0.1957
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.091 0.0836
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0584 0.0564
Toxoplasma gondii ImpB/MucB/SamB family protein 0.004 0.0954 0.1737
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.0502 0.0409
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.091 0.0891
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0083 0.0062
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0026 0.0502 0.0482
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0789 0.077
Loa Loa (eye worm) hypothetical protein 0.002 0.0314 0.0345
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0993 0.0974
Loa Loa (eye worm) hypothetical protein 0.0014 0.0111 0.0119
Schistosoma mansoni tar DNA-binding protein 0.0068 0.184 0.2037
Brugia malayi glutaminase DH11.1 0.0295 0.902 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.091 0.1006
Echinococcus multilocularis muscleblind protein 0.0161 0.4781 0.8704
Toxoplasma gondii peptidylprolyl isomerase 0.0035 0.0789 0.1436
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0314 0.024
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.091 0.0836
Schistosoma mansoni alpha-glucosidase 0.0151 0.4469 0.4952
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0993 0.0974
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0184 0.5493 1
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0138 0.4054 0.4492
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0314 0.0345
Echinococcus granulosus Regulator of G protein signaling 20 0.0014 0.0111 0.0196
Brugia malayi Regulator of G protein signaling domain containing protein 0.0014 0.0111 0.0119
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0026 0.0502 0.0482
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0037 0.0847 0.0827
Schistosoma mansoni regulator of G protein signaling 0.0014 0.0111 0.0119
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0067 0.181 0.1793
Loa Loa (eye worm) hepatopoietin HPO2 0.0037 0.0847 0.0936
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0993 0.1018
Trichomonas vaginalis rotamase, putative 0.0035 0.0789 0.071
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0083 0.0062
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0042 0.0993 0.1098
Plasmodium falciparum phosphoglycerate kinase 0.0184 0.5493 1
Schistosoma mansoni regulator of G protein signaling 0.0014 0.0111 0.0119
Brugia malayi hypothetical protein 0.0014 0.0111 0.0119
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0316 0.9667 1
Trypanosoma brucei phosphoglycerate kinase 0.0184 0.5493 0.5483
Echinococcus granulosus dna polymerase eta 0.0069 0.1864 0.3391
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0013 0.0083 0.0152
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0694 0.1259
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0134 0.0025
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0134 0.0025
Mycobacterium ulcerans phosphoglycerate kinase 0.0184 0.5493 0.6053
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0035 0.0789 0.0816
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0184 0.5493 0.5483
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0326 1 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0042 0.0993 0.0974
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0033 0.071 0.1292
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0125 0.3617 0.6582
Giardia lamblia DINP protein human, muc B family 0.0042 0.0993 0.095
Loa Loa (eye worm) RecQ helicase 0.0049 0.1224 0.1354
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.091 0.0836
Brugia malayi Augmenter of liver regeneration 0.0037 0.0847 0.0936
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0993 0.0974
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0026 0.0502 0.0482
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0314 0.0566
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0694 0.0767
Entamoeba histolytica deoxycytidyl transferase, putative 0.0042 0.0993 0.1028
Entamoeba histolytica hypothetical protein 0.0014 0.0111 0.0115
Leishmania major hypothetical protein, conserved 0.0037 0.0847 0.0827
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0314 0.0566
Echinococcus multilocularis dnaJ subfamily C 6 0.0066 0.1768 0.3215
Echinococcus granulosus axis inhibition protein axin 0.0014 0.0111 0.0196
Trypanosoma brucei phosphoglycerate kinase 0.0067 0.181 0.1793
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0134 0.0113
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0225 0.679 0.7526
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0042 0.0993 0.1804
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0993 0.0974
Mycobacterium tuberculosis Conserved hypothetical protein 0.0172 0.5113 0.9156
Schistosoma mansoni tar DNA-binding protein 0.0068 0.184 0.2037
Brugia malayi Muscleblind-like protein 0.0161 0.4781 0.5299
Trypanosoma cruzi DNA polymerase eta, putative 0.004 0.0954 0.0935
Loa Loa (eye worm) PXA domain-containing protein 0.0014 0.0111 0.0119
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.091 0.0836
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.091 0.0836
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0993 0.0974
Echinococcus multilocularis expressed protein 0.0014 0.0111 0.0196
Loa Loa (eye worm) hypothetical protein 0.0184 0.5493 0.6088
Echinococcus multilocularis tar DNA binding protein 0.0068 0.184 0.3345
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0037 0.0847 0.1411
Brugia malayi PXA domain containing protein 0.0014 0.0111 0.0119
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0046 0.1126 0.1107
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0993 0.0974
Brugia malayi polk-prov protein 0.0013 0.0083 0.0089
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0037 0.0847 0.0827
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0316 0.9667 1
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0083 0.0062
Onchocerca volvulus 0.0102 0.2896 0.3723
Loa Loa (eye worm) hypothetical protein 0.0013 0.0083 0.0089
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.091 0.0891
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0134 0.0025
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0015 0.0134 0.0169
Toxoplasma gondii hypothetical protein 0.0053 0.1339 0.2438
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0184 0.5493 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0657 0.1191
Schistosoma mansoni terminal deoxycytidyl transferase 0.0042 0.0993 0.1098
Brugia malayi ImpB/MucB/SamB family protein 0.0042 0.0993 0.1098
Echinococcus granulosus dna polymerase kappa 0.0042 0.0993 0.1804
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0316 0.9667 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0111 0.0119
Echinococcus granulosus regulator of G protein signaling 3 0.0014 0.0111 0.0196
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0816 0.0738
Entamoeba histolytica recQ family helicase, putative 0.0026 0.0502 0.0519
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0584 0.0564
Trypanosoma brucei unspecified product 0.0029 0.0584 0.0564
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0014 0.0111 0.0119
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0993 0.0974
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.091 0.0941
Trypanosoma brucei glucosidase, putative 0.0039 0.091 0.0891
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0014 0.0111 0.0119
Echinococcus granulosus beta-adrenergic receptor kinase 0.0014 0.0121 0.0215
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0134 0.0113
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0037 0.0847 0.1537
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0993 0.0974
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0314 0.0345
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0067 0.181 0.1793
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.091 0.0836
Schistosoma mansoni alpha glucosidase 0.0039 0.091 0.1006
Trypanosoma cruzi DNA polymerase eta, putative 0.0069 0.1864 0.1847
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0314 0.0566
Leishmania major DNA damage repair protein, putative 0.0013 0.0083 0.0062
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0015 0.0134 0.0139
Loa Loa (eye worm) hypothetical protein 0.0014 0.0111 0.0119
Echinococcus granulosus dnaJ subfamily C 6 0.0066 0.1768 0.3215
Brugia malayi hypothetical protein 0.0014 0.0111 0.0119
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.1126 0.1107
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.1126 0.1107
Onchocerca volvulus 0.0256 0.7773 1
Trypanosoma brucei DNA polymerase eta, putative 0.0069 0.1864 0.1847
Schistosoma mansoni serine/threonine protein kinase 0.0138 0.4054 0.4492
Brugia malayi TAR-binding protein 0.0068 0.184 0.2037
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0184 0.5493 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0056 0.1443 0.1425
Brugia malayi Pre-SET motif family protein 0.0032 0.0694 0.0767
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0014 0.0111 0.0119
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0125 0.3617 0.6582
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0125 0.3617 0.4007
Echinococcus multilocularis regulator of G protein signaling 3 0.0014 0.0111 0.0196
Leishmania major glycosyl hydrolase-like protein 0.0015 0.0134 0.0113
Brugia malayi Bloom's syndrome protein homolog 0.0049 0.1224 0.1354
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0083 0.0062
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0316 0.9667 1
Entamoeba histolytica phosphoglycerate kinase, putative 0.0184 0.5493 0.5682
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0176 0.5244 0.5812
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0993 0.0974
Brugia malayi ImpB/MucB/SamB family protein 0.0069 0.1864 0.2064
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0314 0.0566
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.091 0.0836
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0014 0.0121 0.0131
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0314 0.0571
Trichomonas vaginalis DNA helicase recq, putative 0.0049 0.1224 0.1165
Echinococcus granulosus lysosomal alpha glucosidase 0.0176 0.5244 0.9547
Brugia malayi regulator of G-protein signaling egl-10 0.0014 0.0111 0.0119
Echinococcus multilocularis bloom syndrome protein 0.0049 0.1224 0.2224
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0014 0.0111 0.0196
Toxoplasma gondii Erv1 / Alr family protein 0.0037 0.0847 0.1541
Brugia malayi Phosphoglycerate kinase 0.0184 0.5493 0.6088
Echinococcus multilocularis dna polymerase eta 0.0069 0.1864 0.3391
Loa Loa (eye worm) hypothetical protein 0.0014 0.0111 0.0119
Schistosoma mansoni DNA polymerase eta 0.0069 0.1864 0.2064
Echinococcus multilocularis regulator of G protein signaling 0.0014 0.0111 0.0196
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0014 0.0111 0.0196
Trypanosoma brucei unspecified product 0.0029 0.0584 0.0564
Brugia malayi Regulator of G protein signaling domain containing protein 0.0014 0.0111 0.0119
Loa Loa (eye worm) hypothetical protein 0.0015 0.0134 0.0145
Trypanosoma brucei phosphoglycerate kinase 0.0184 0.5493 0.5483
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0042 0.0993 0.1804
Schistosoma mansoni phosphoglycerate kinase 0.0184 0.5493 0.6088
Brugia malayi Glycosyl hydrolases family 31 protein 0.0176 0.5244 0.5812
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0134 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0993 0.0974
Echinococcus multilocularis lysosomal alpha glucosidase 0.0176 0.5244 0.9547
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0993 0.0974
Loa Loa (eye worm) hypothetical protein 0.0069 0.1864 0.2064
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0993 0.0974
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0035 0.0789 0.077
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0154 0.4555 0.7916
Leishmania major DNA polymerase kappa, putative 0.0013 0.0083 0.0062
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0789 0.077
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0037 0.0847 0.1537
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0134 0.0025
Leishmania major DNA polymerase kappa, putative 0.0042 0.0993 0.0974
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0694 0.1259
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0134 0.0025
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0036 0.0816 0.0901
Schistosoma mansoni DNA helicase recq5 0.002 0.0314 0.0345
Schistosoma mansoni glutaminase 0.0295 0.902 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0993 0.0974
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0125 0.3617 0.4007
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0154 0.4561 0.4549
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0042 0.0993 0.0924
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0993 0.0974
Loa Loa (eye worm) hypothetical protein 0.0149 0.4387 0.4862
Plasmodium vivax phosphoglycerate kinase, putative 0.0184 0.5493 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0314 0.0571
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0134 0.0025
Schistosoma mansoni regulator of G protein signaling 0.0014 0.0111 0.0119
Echinococcus granulosus phosphoglycerate kinase 1 0.0184 0.5493 1
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0121 0.0131
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0154 0.4561 0.4549
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0036 0.0816 0.0901
Trypanosoma brucei phosphoglycerate kinase, putative 0.0067 0.181 0.1793
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0067 0.181 0.1793
Echinococcus multilocularis beta adrenergic receptor kinase 0.0014 0.0121 0.0215
Trichomonas vaginalis set domain proteins, putative 0.0256 0.7773 0.8018
Echinococcus granulosus expressed protein 0.0036 0.0816 0.148
Brugia malayi Pre-SET motif family protein 0.0225 0.679 0.7526
Trichomonas vaginalis DNA polymerase eta, putative 0.0042 0.0993 0.0924
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.091 0.1652
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0314 0.0345
Loa Loa (eye worm) hypothetical protein 0.0161 0.4781 0.5299
Loa Loa (eye worm) TAR-binding protein 0.0068 0.184 0.2037
Loa Loa (eye worm) glutaminase 0.0295 0.902 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0014 0.0111 0.0196
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0184 0.5493 0.5632
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0083 0.0062
Brugia malayi PXA domain containing protein 0.0014 0.0111 0.0119
Loa Loa (eye worm) hypothetical protein 0.0014 0.0111 0.0119
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.091 0.1652
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0993 0.0974
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0013 0.0083 0.0152
Trypanosoma brucei glycosyl hydrolase-like protein 0.0015 0.0134 0.0113
Entamoeba histolytica hypothetical protein 0.0014 0.0111 0.0115
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0083 0.0062
Brugia malayi A-kinase anchor protein 10, precursor 0.0014 0.0111 0.0119
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0694 0.0767
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0316 0.9667 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0316 0.9667 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0694 0.0767
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0043 0.1036 0.1761
Echinococcus multilocularis dna polymerase kappa 0.0042 0.0993 0.1804
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0083 0.0062
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0316 0.9667 1
Loa Loa (eye worm) hypothetical protein 0.0161 0.4781 0.5299
Loa Loa (eye worm) RGS-3 protein 0.0014 0.0111 0.0119
Brugia malayi DnaJ domain containing protein 0.0066 0.1768 0.1957
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0993 0.0974
Echinococcus granulosus regulator of G protein signaling 7 0.0014 0.0111 0.0196
Schistosoma mansoni phosphoglycerate kinase 0.0184 0.5493 0.6088

Activities

Activity type Activity value Assay description Source Reference
LD10 (ADMET) = 21 mg kg-1 Toxicity in mouse L1210 cells xenografted mouse assessed as compound proving lethal to 10% animal ChEMBL. 536990

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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