Detailed information for compound 1864909

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 479.248 | Formula: C22H25Br2NO
  • H donors: 1 H acceptors: 1 LogP: 6.78 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCN(CC(c1cc2cc(Br)ccc2c2c1ccc(c2)Br)O)CCC
  • InChi: 1S/C22H25Br2NO/c1-3-9-25(10-4-2)14-22(26)21-12-15-11-16(23)5-7-18(15)20-13-17(24)6-8-19(20)21/h5-8,11-13,22,26H,3-4,9-10,14H2,1-2H3
  • InChiKey: QLNYJDZODATQGW-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0039 0.004
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.3505 0.6216
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0088 0.009
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0088 0.0099
Brugia malayi MH1 domain containing protein 0.0008 0.0039 0.0072
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.5413 0.9599
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0159 0.339 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.121 0.3534
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0088 0.0163
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0214 0.0218
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0143 0.302 0.558
Loa Loa (eye worm) hypothetical protein 0.001 0.0088 0.0088
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.2429 0.2429
Echinococcus granulosus smad 0.0008 0.0039 0.004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0009 0.0015
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0088 0.009
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0477 0.385
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0088 0.0163
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.1195 0.3489
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0039 0.004
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0477 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.1195 0.3489
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0969 0.0969
Trypanosoma brucei cysteine peptidase, Clan CA, family C54, putative 0.0024 0.0398 0.3124
Loa Loa (eye worm) hypothetical protein 0.0018 0.0257 0.0257
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0023 0.0366 0.5
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.121 0.123
Loa Loa (eye worm) hypothetical protein 0.001 0.0088 0.0088
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0088 0.009
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0088 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0088 0.0163
Entamoeba histolytica peptidase, C54 family 0.0024 0.0398 0.3228
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.039 0.1101
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.1097 0.905
Loa Loa (eye worm) hypothetical protein 0.001 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.001 0.0088 0.0088
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0088 0.0099
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0088 0.009
Loa Loa (eye worm) hypothetical protein 0.0062 0.1232 0.1232
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0088 0.0088
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.121 0.9819
Brugia malayi AMP-binding enzyme family protein 0.0024 0.039 0.072
Schistosoma mansoni smad 0.0008 0.0039 0.0044
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.3505 0.6216
Onchocerca volvulus 0.0029 0.0501 0.0501
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.302 0.3382
Trypanosoma cruzi cysteine peptidase, Clan CA, family C54, putative 0.0024 0.0398 0.3124
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0969 0.1791
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0023 0.0366 0.1029
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0257 0.5196
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0088 0.0163
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0023 0.0366 0.1029
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.039 0.3059
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0062 0.1232 1
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0023 0.0366 0.1029
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0088 0.0163
Loa Loa (eye worm) hypothetical protein 0.001 0.0088 0.0088
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0159 0.339 1
Echinococcus granulosus ornithine aminotransferase 0.0023 0.0366 0.0372
Schistosoma mansoni hypothetical protein 0.0034 0.062 0.0694
Echinococcus multilocularis ornithine aminotransferase 0.0023 0.0366 0.0372
Schistosoma mansoni hypothetical protein 0.0016 0.0214 0.024
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.039 0.3164
Brugia malayi hypothetical protein 0.0028 0.0477 0.0882
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0039 0.0039
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0088 0.009
Loa Loa (eye worm) hypothetical protein 0.001 0.0088 0.0088
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0501 0.0501
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0477 0.7833
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0251 0.5413 1
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0062 0.1232 0.138
Loa Loa (eye worm) oxidoreductase 0.0007 0.0019 0.0019
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0007 0.0019 0.0019
Mycobacterium ulcerans L-lysine aminotransferase 0.0023 0.0366 0.1029
Echinococcus multilocularis geminin 0.0186 0.3985 0.4052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0088 0.0088
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0062 0.1232 0.138
Echinococcus granulosus GPCR family 2 0.0016 0.0214 0.0218
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0088 0.009
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.039 0.3164
Onchocerca volvulus Phospholipase A2 homolog 0.0096 0.1998 0.1998
Plasmodium vivax SET domain protein, putative 0.0033 0.0604 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0009 0.0015
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0236 0.0643
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0009 0.0015
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0009 0.0015
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0477 0.378
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0088 0.0099
Plasmodium vivax ornithine aminotransferase, putative 0.0023 0.0366 0.5924
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.302 0.3071
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.039 0.1101
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0477 1
Schistosoma mansoni smad1 5 8 and 0.0008 0.0039 0.0044
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0039 0.0044
Loa Loa (eye worm) hypothetical protein 0.0024 0.039 0.039
Loa Loa (eye worm) hypothetical protein 0.005 0.0969 0.0969
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0088 0.0099
Schistosoma mansoni hypothetical protein 0.0016 0.0214 0.024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.302 0.3382
Onchocerca volvulus 0.001 0.0088 0.0088
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0023 0.0366 0.1029
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0088 0.0088
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.3505 0.6216
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0086 0.0158
Entamoeba histolytica peptidase, C54 family 0.0062 0.1232 1
Onchocerca volvulus Phospholipase A2 homolog 0.0458 1 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0049 0.0055
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.121 0.123
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0088 0.009
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0049 0.005
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0088 0.0163
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.121 0.1355
Entamoeba histolytica peptidase, C54 family 0.0024 0.0398 0.3228
Schistosoma mansoni cpg binding protein 0.0029 0.0501 0.0561
Loa Loa (eye worm) hypothetical protein 0.0028 0.0477 0.0477
Echinococcus granulosus cpg binding protein 0.003 0.0537 0.0546
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0009 0.0015
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.039 0.1101
Brugia malayi MH2 domain containing protein 0.0008 0.0039 0.0072
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0604 0.0677
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0088 0.0163
Brugia malayi ecdysteroid receptor 0.001 0.0088 0.0163
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.5413 0.9599
Echinococcus granulosus Aminotransferase class III 0.0023 0.0366 0.0372
Schistosoma mansoni nuclear hormone receptor 0.001 0.0088 0.0099
Echinococcus multilocularis Smad4 0.0008 0.0039 0.004
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0088 0.0099
Loa Loa (eye worm) histone methyltransferase 0.001 0.0088 0.0088
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0214 0.0395
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.039 0.1101
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0088 0.009
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.3505 0.6216
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0088 0.009
Loa Loa (eye worm) hypothetical protein 0.0034 0.062 0.062
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0143 0.302 0.302
Echinococcus granulosus FTZ F1 alpha 0.001 0.0088 0.009
Onchocerca volvulus 0.0007 0.0019 0.0019
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.039 0.1101
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.0019 0.0021
Brugia malayi hypothetical protein 0.0018 0.026 0.0481
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0023 0.0366 0.2912
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0214 0.0218
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.039 0.1101
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.039 0.1101
Schistosoma mansoni Smad4 0.0008 0.0039 0.0044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0088 0.0088
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.062 0.1145
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0007 0.0019 0.0152
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0023 0.0366 0.1029
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0023 0.0366 0.1029
Loa Loa (eye worm) hypothetical protein 0.001 0.0088 0.0088
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.039 0.3059
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.039 0.1101
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.302 0.3071
Mycobacterium tuberculosis Probable aminotransferase 0.0159 0.339 1
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0024 0.0398 0.3124
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0023 0.0366 0.0675
Schistosoma mansoni hypothetical protein 0.0016 0.0214 0.024
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0062 0.1232 0.2185
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0604 0.0677
Loa Loa (eye worm) hypothetical protein 0.001 0.0088 0.0088
Brugia malayi MH2 domain containing protein 0.0116 0.2429 0.4488
Onchocerca volvulus 0.0024 0.039 0.039
Echinococcus granulosus neuropeptide s receptor 0.045 0.9836 1
Echinococcus multilocularis neuropeptide s receptor 0.045 0.9836 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0009 0.0015
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0088 0.009
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0019 0.0033
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0139 0.0142
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0062 0.1232 0.2185
Entamoeba histolytica peptidase, C54 family 0.0024 0.0398 0.3228
Brugia malayi Peptidase family C54 containing protein 0.0062 0.1232 0.2276
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0007 0.0019 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0009 0.0015
Echinococcus multilocularis GPCR, family 2 0.0016 0.0214 0.0218
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0477 0.378
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0088 0.0163
Brugia malayi follicle stimulating hormone receptor 0.0245 0.5287 0.9767
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0039 0.004
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0214 0.0214
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0049 0.005
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0088 0.009
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0024 0.0398 0.3124
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.1241 0.139
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.1105 0.1105
Schistosoma mansoni hypothetical protein 0.0186 0.3985 0.4463
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0088 0.009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0088 0.009
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.3505 0.6216
Schistosoma mansoni smad1 5 8 and 0.0008 0.0039 0.0044
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.5413 0.9599
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0236 0.0643
Brugia malayi nuclear receptor NHR-88 0.001 0.0088 0.0163
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0236 0.0643
Brugia malayi Pre-SET motif family protein 0.0033 0.0604 0.1116
Schistosoma mansoni cpg binding protein 0.003 0.0537 0.0602
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.006 0.1195 0.3489
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0604 0.0614
Brugia malayi nuclear hormone receptor 0.001 0.0088 0.0163
Entamoeba histolytica peptidase, C54 family 0.0024 0.0398 0.3228
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0604 0.0677
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0214 0.0218
Echinococcus multilocularis ornithine aminotransferase 0.0023 0.0366 0.0372
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0009 0.0015
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0023 0.0366 0.1029
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0251 0.5413 0.5413
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0604 0.0614
Loa Loa (eye worm) hypothetical protein 0.0018 0.0257 0.0257
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.1195 0.2207
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0049 0.005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0088 0.0088
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0023 0.0366 0.0409
Loa Loa (eye worm) hypothetical protein 0.0016 0.0214 0.0214
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0039 0.0039
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0019 0.0019
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0604 0.0614
Schistosoma mansoni hypothetical protein 0.0016 0.0214 0.024
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0019 0.0035
Echinococcus multilocularis cpg binding protein 0.003 0.0537 0.0546
Brugia malayi CXXC zinc finger family protein 0.0029 0.0501 0.0925
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0159 0.339 1
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0062 0.1232 0.2185
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0088 0.0163
Brugia malayi Pre-SET motif family protein 0.0229 0.494 0.9126
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0023 0.0366 1
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0477 0.378
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0088 0.009
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.006 0.1195 0.1338
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.039 0.1101
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0088 0.0088
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative 0.0062 0.1232 1
Onchocerca volvulus 0.0261 0.5639 0.5639
Brugia malayi Phospholipase A2 family protein 0.0096 0.1998 0.3692
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.5413 0.9599
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0088 0.0088
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0214 0.0218
Schistosoma mansoni hypothetical protein 0.0409 0.893 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0088 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0009 0.0015
Mycobacterium ulcerans hypothetical protein 0.0159 0.339 1
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0023 0.0366 0.1029
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0023 0.0366 0.1029
Echinococcus granulosus Peptidase C54 0.0062 0.1232 0.1253
Toxoplasma gondii autophagy-related cysteine peptidase atg4, putative 0.0024 0.0398 0.3182
Mycobacterium ulcerans hypothetical protein 0.0024 0.039 0.1101
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0007 0.0019 0.0019
Mycobacterium ulcerans acetylornithine aminotransferase 0.0023 0.0366 0.1029
Schistosoma mansoni hypothetical protein 0.0012 0.0139 0.0156
Loa Loa (eye worm) Smad1 0.0008 0.0039 0.0039
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0062 0.1232 0.2185
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0019
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0088 0.009
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0088 0.0163
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.121 0.1355
Echinococcus granulosus geminin 0.0186 0.3985 0.4052
Loa Loa (eye worm) hypothetical protein 0.0018 0.0257 0.0257
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0019 0.0019
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0088 0.0099
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0049 0.005
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0139 0.0142
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0088 0.009
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0019 0.0035
Loa Loa (eye worm) hypothetical protein 0.0018 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.0024 0.039 0.039
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0257 0.0707
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0088 0.0163
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0088 0.009
Echinococcus multilocularis dnaJ subfamily B 0.0409 0.893 0.9078
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0009 0.0015
Brugia malayi AMP-binding enzyme family protein 0.0024 0.039 0.072
Loa Loa (eye worm) hypothetical protein 0.0018 0.0257 0.0257
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.302 0.3071
Echinococcus multilocularis Peptidase C54 0.0062 0.1232 0.1253
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0019
Echinococcus granulosus cysteine protease atg4b 0.0062 0.1232 0.1253
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0257 0.0707
Schistosoma mansoni cpg binding protein 0.003 0.0537 0.0602
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.302 0.3382
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0564 0.0573
Onchocerca volvulus 0.0007 0.0019 0.0019
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.3701 0.6563
Brugia malayi steroid hormone receptor 0.001 0.0088 0.0163
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0088 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0009 0.0015
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0088 0.0099
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.121 0.3534
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0088 0.0088
Echinococcus multilocularis Aminotransferase class III 0.0023 0.0366 0.0372
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.302 0.3071
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.3505 0.6216
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0088 0.0088
Schistosoma mansoni hypothetical protein 0.0186 0.3985 0.4463
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0969 0.1791
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0088 0.0163
Plasmodium falciparum ornithine aminotransferase 0.0023 0.0366 0.7563
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.121 0.3534
Onchocerca volvulus 0.0011 0.0108 0.0108
Plasmodium falciparum cysteine protease ATG4, putative 0.0024 0.0398 0.8264
Trichomonas vaginalis helicase, putative 0.0007 0.0009 0.0015
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0019 0.0033
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.2429 0.2429
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0019 0.0035
Echinococcus multilocularis cysteine protease atg4b 0.0062 0.1232 0.1253
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0023 0.0366 0.1029
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0604 0.0677
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0257 0.407
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0245 0.5287 0.5287
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.3701 0.6563
Trichomonas vaginalis set domain proteins, putative 0.0261 0.5639 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0039 0.004
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0088 0.0163
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0088 0.0088
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0019 0.0035
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0159 0.339 0.6011
Onchocerca volvulus 0.0007 0.0019 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0088 0.0163
Echinococcus granulosus Smad4 0.0008 0.0039 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0009 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0009 0.0015
Brugia malayi MH2 domain containing protein 0.0008 0.0039 0.0072
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0229 0.494 0.494
Schistosoma mansoni thyroid hormone receptor 0.001 0.0088 0.0099
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.3505 0.6216
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.5413 0.9599
Loa Loa (eye worm) hypothetical protein 0.0096 0.1998 0.1998
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.121 0.3534
Schistosoma mansoni smad1 5 8 and 0.0008 0.0039 0.0044
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.121 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.039 0.1101
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.039 0.3164
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0236 0.0643
Onchocerca volvulus Glucosylceramidase homolog 0.0164 0.3505 0.3505
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0009 0.0015
Echinococcus granulosus neuropeptide receptor A26 0.045 0.9836 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0009 0.0015
Schistosoma mansoni thyroid hormone receptor 0.001 0.0088 0.0099
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0214 0.0395
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0088 0.0088
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.039 0.3059
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.039 0.1101
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0088 0.0163
Onchocerca volvulus 0.0033 0.0604 0.0604
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0088 0.0163
Echinococcus multilocularis smad 0.0008 0.0039 0.004
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0062 0.1232 1
Schistosoma mansoni autophagin-1 (C54 family) 0.0062 0.1232 0.138
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.1195 0.1215
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0019 0.0035
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.006 0.1195 0.9693
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0009 0.0015
Echinococcus multilocularis neuropeptide receptor A26 0.045 0.9836 1
Brugia malayi MH1 domain containing protein 0.0008 0.0039 0.0072
Loa Loa (eye worm) hypothetical protein 0.0024 0.039 0.039
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0009 0.0015
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0062 0.1232 0.2185
Echinococcus granulosus dnaJ subfamily B 0.0409 0.893 0.9078
Schistosoma mansoni coup transcription factor 0.001 0.0088 0.0099
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0088 0.0099
Brugia malayi AMP-binding enzyme family protein 0.0024 0.039 0.072
Loa Loa (eye worm) hypothetical protein 0.0033 0.0604 0.0604
Leishmania major hypothetical protein, conserved 0.0028 0.0477 0.378
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.5413 0.9599
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0023 0.0366 0.1029
Brugia malayi Smad1 0.0008 0.0039 0.0072
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0604 0.4915
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.1195 0.1215

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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