TDR Targets

Basic information

Technical information

TDR Targets ID: 1869018
Name: (2,4-dihydroxyphenyl)-(3,4-dihydroxyphenyl)me thanone
MW: 246.215 | Formula: C13H10O5
H donors: 4 H acceptors: 5 LogP: 2.39 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Oc1ccc(c(c1)O)C(=O)c1ccc(c(c1)O)O
InChi: 1S/C13H10O5/c14-8-2-3-9(11(16)6-8)13(18)7-1-4-10(15)12(17)5-7/h1-6,14-17H
InChiKey: UQQYIAVMUUJWGX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	androgen receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.004	0.0506	0.1118
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0035	0.04	0.0855
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0021	0.0114	0.0086
Schistosoma mansoni	hypothetical protein	0.0113	0.2092	0.3034
Brugia malayi	ImpB/MucB/SamB family protein	0.0023	0.0156	0.0148
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0025	0.0198	0.0211
Echinococcus multilocularis	dna polymerase kappa	0.0023	0.0156	0.0247
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0113	0.2092	0.5058
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0156	0.0382
Trichomonas vaginalis	glutaminase, putative	0.033	0.6763	1
Mycobacterium ulcerans	DNA polymerase IV	0.0023	0.0156	0.0148
Giardia lamblia	Phosphoglycerate kinase	0.0206	0.408	1
Echinococcus granulosus	TRP transient receptor potential channel	0.0036	0.0427	0.092
Entamoeba histolytica	protein kinase, putative	0.0035	0.04	0.0855
Trypanosoma brucei	DNA polymerase eta, putative	0.0054	0.0818	0.2005
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.0114	0.0143
Echinococcus granulosus	phosphoglycerate kinase 1	0.0206	0.408	1
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.005	0.0734	0.201
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.059	0.1325
Giardia lamblia	Lysyl-tRNA synthetase	0.0025	0.0198	0.0352
Mycobacterium leprae	Possible D-ribose-binding protein	0.0322	0.6593	1
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0425	0.0477
Echinococcus multilocularis	transient receptor potential ion channel A	0.0093	0.1662	0.3991
Giardia lamblia	Prolyl-tRNA synthetase	0.0034	0.0385	0.0817
Trichomonas vaginalis	phosphoglycerate kinase, putative	0.0206	0.408	0.5999
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0113	0.2092	0.5058
Loa Loa (eye worm)	glutaminase 2	0.033	0.6763	1
Brugia malayi	Transient-receptor-potential like protein	0.0036	0.0427	0.0552
Trypanosoma brucei	glucose transporter, putative	0.0035	0.041	0.1005
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0021	0.0114	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0425	0.0549
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.5056	0.7455
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0022	0.0131	0.0111
Echinococcus granulosus	dna polymerase eta	0.0054	0.0818	0.1893
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.0114	0.0143
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0425	0.0814
Brugia malayi	nuclear hormone receptor	0.0021	0.0114	0.0086
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0034	0.0385	0.049
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0021	0.0114	0.0086
Brugia malayi	mbt repeat family protein	0.005	0.0734	0.101
Echinococcus multilocularis	short transient receptor potential channel 6	0.0064	0.1028	0.2415
Trichomonas vaginalis	esterase, putative	0.0036	0.0425	0.0549
Brugia malayi	Phosphoglycerate kinase	0.0075	0.1279	0.1822
Echinococcus multilocularis	FTZ F1 alpha	0.0021	0.0114	0.0143
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0114	0.0086
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0034	0.0385	0.049
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0021	0.0114	0.0143
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0156	0.0382
Schistosoma mansoni	transient receptor potential channel 4	0.0096	0.1732	0.2498
Leishmania major	phosphoglycerate kinase C, glycosomal	0.0206	0.408	1
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0035	0.04	0.0513
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0035	0.0401	0.0346
Brugia malayi	beta-lactamase	0.0036	0.0425	0.0549
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.059	0.1325
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.0114	0.0143
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0021	0.0114	0.0086
Echinococcus granulosus	SAM and MBT domain containing protein	0.005	0.0734	0.1683
Entamoeba histolytica	phosphoglycerate kinase, putative	0.0206	0.408	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.3199	0.4685
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0057	0.0883	0.2055
Mycobacterium ulcerans	phosphoglycerate kinase	0.0206	0.408	0.5999
Schistosoma mansoni	protein kinase	0.0035	0.04	0.0513
Schistosoma mansoni	transient receptor potential channel	0.0064	0.1028	0.1449
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0075	0.1279	0.3038
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0023	0.0156	0.0148
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0021	0.0114	0.0086
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0025	0.0198	0.0211
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.04	0.0855
Echinococcus granulosus	dna polymerase kappa	0.0023	0.0156	0.0247
Trypanosoma cruzi	hexose transporter, putative	0.0019	0.0067	0.0026
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0035	0.04	0.0981
Plasmodium vivax	hexose transporter	0.0113	0.2092	0.2047
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0425	0.0814
Trypanosoma brucei	unspecified product	0.0023	0.0156	0.0382
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.04	0.0855
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.5056	0.7455
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0156	0.0382
Onchocerca volvulus		0.005	0.0734	0.201
Brugia malayi	glutaminase DH11.1	0.033	0.6763	1
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0023	0.0156	0.0247
Trypanosoma brucei	phosphoglycerate kinase	0.0206	0.408	1
Mycobacterium leprae	Probable phosphoglycerate kinase Pgk	0.0206	0.408	0.6121
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0113	0.2092	0.5058
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0425	0.0549
Trichomonas vaginalis	sugar transporter, putative	0.0035	0.041	0.0527
Loa Loa (eye worm)	MBCTL1	0.0057	0.0883	0.1233
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.004	0.0506	0.1118
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0113	0.2092	0.5058
Schistosoma mansoni	thyroid hormone receptor	0.0021	0.0114	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0035	0.04	0.0513
Schistosoma mansoni	ets-related	0.0265	0.5372	0.7925
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0025	0.0198	0.0485
Leishmania major	lysyl-tRNA synthetase, putative	0.0025	0.0198	0.0352
Leishmania major	DNA polymerase eta, putative	0.0038	0.0472	0.1033
Trichomonas vaginalis	glucosylceramidase, putative	0.0173	0.3389	0.4969
Trypanosoma brucei	glucose transporter 2A	0.0035	0.041	0.1005
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0021	0.0114	0.0143
Brugia malayi	photoreceptor-specific nuclear receptor	0.0021	0.0114	0.0086
Echinococcus multilocularis	transient receptor potential gamma protein	0.0096	0.1732	0.4163
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0035	0.0401	0.0531
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0023	0.0156	0.0148
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0113	0.2092	0.5058
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0113	0.2092	0.5058
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0034	0.0385	0.0817
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0034	0.0385	0.049
Entamoeba histolytica	hypothetical protein	0.0043	0.059	0.1325
Trypanosoma cruzi	DNA polymerase eta, putative	0.0054	0.0818	0.1893
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0425	0.0549
Schistosoma mansoni	glutaminase	0.033	0.6763	1
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0023	0.0156	0.0148
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0425	0.0549
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0021	0.0114	0.0086
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0025	0.0198	0.0211
Echinococcus granulosus	polycomb protein SCMH1	0.005	0.0734	0.1683
Schistosoma mansoni	sex comb on midleg homolog	0.005	0.0734	0.101
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0156	0.0247
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0425	0.037
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0156	0.0247
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0156	0.0382
Onchocerca volvulus		0.0036	0.0425	0.1007
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0021	0.0114	0.0086
Echinococcus multilocularis	short transient receptor potential channel 6	0.0064	0.1028	0.2415
Loa Loa (eye worm)	RNA binding protein	0.0076	0.1301	0.1856
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0021	0.0114	0.0143
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0425	0.0549
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0035	0.0401	0.0531
Schistosoma mansoni	protein kinase	0.0035	0.04	0.0513
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0156	0.0382
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0035	0.0401	0.0531
Schistosoma mansoni	serine/threonine protein kinase	0.0035	0.04	0.0513
Plasmodium falciparum	protein kinase 7	0.032	0.6541	0.6522
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0021	0.0114	0.0143
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0156	0.0382
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0425	0.0549
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0021	0.0114	0.0143
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0229	0.4578	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0173	0.3389	0.4969
Plasmodium vivax	proline--tRNA ligase, putative	0.004	0.0506	0.0452
Plasmodium vivax	CDK-related protein kinase 6, putative	0.048	1	1
Trichomonas vaginalis	phosphoglycerate kinase, putative	0.0206	0.408	0.5999
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0425	0.0549
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0114	0.0086
Onchocerca volvulus		0.0036	0.0425	0.1007
Leishmania major	glucose transporter, lmgt3	0.0035	0.041	0.0878
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0021	0.0114	0.0086
Toxoplasma gondii	protein kinase, putative	0.032	0.6541	1
Trichomonas vaginalis	sugar transporter, putative	0.0035	0.041	0.0527
Trypanosoma brucei	glucose transporter, putative	0.0035	0.041	0.1005
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0425	0.0915
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0425	0.0915
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.004	0.0506	0.1118
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0021	0.0114	0.0086
Brugia malayi	hypothetical protein	0.015	0.2889	0.4223
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0021	0.0114	0.0086
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0114	0.0086
Schistosoma mansoni	transient receptor potential channel	0.0064	0.1028	0.1449
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1732	0.2498
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.1301	0.1856
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0034	0.0385	0.0416
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0021	0.0114	0.0086
Echinococcus granulosus	FTZ F1 alpha	0.0021	0.0114	0.0143
Leishmania major	DNA polymerase kappa, putative	0.0023	0.0156	0.0247
Echinococcus granulosus	histone acetyltransferase MYST2	0.0057	0.0883	0.2055
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0114	0.0086
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0425	0.0549
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.1301	0.1856
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0425	0.0549
Mycobacterium ulcerans	DNA polymerase IV	0.0023	0.0156	0.0148
Entamoeba histolytica	hypothetical protein	0.0025	0.0198	0.0352
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.04	0.0855
Leishmania major	hypothetical protein, conserved	0.0036	0.0425	0.0915
Brugia malayi	Steroid receptor seven-up type 2	0.0021	0.0114	0.0086
Mycobacterium ulcerans	lipase LipD	0.0036	0.0425	0.0549
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0818	0.1136
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.3199	0.4685
Plasmodium falciparum	phosphoglycerate kinase	0.0206	0.408	0.4047
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.059	0.0795
Mycobacterium tuberculosis	Probable phosphoglycerate kinase Pgk	0.0206	0.408	0.8899
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0035	0.04	0.0855
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0057	0.0883	0.1233
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0206	0.408	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0021	0.0114	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0114	0.0086
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0114	0.0086
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0156	0.0382
Schistosoma mansoni	transient receptor potential channel	0.0096	0.1732	0.2498
Brugia malayi	beta-lactamase family protein	0.0036	0.0425	0.0549
Toxoplasma gondii	ABC1 family protein	0.0036	0.0425	0.0568
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0206	0.408	1
Trypanosoma brucei	glucose transporter, putative	0.0035	0.041	0.1005
Trypanosoma brucei	glucose transporter 1E	0.0035	0.041	0.1005
Trypanosoma cruzi	hexose transporter, putative	0.0035	0.041	0.0878
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0113	0.2092	0.5058
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0425	0.0549
Schistosoma mansoni	hypothetical protein	0.0043	0.059	0.0795
Brugia malayi	nuclear receptor NHR-88	0.0021	0.0114	0.0086
Plasmodium falciparum	proline--tRNA ligase	0.004	0.0506	0.0452
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.04	0.0855
Echinococcus multilocularis	General substrate transporter	0.0097	0.1749	0.4206
Echinococcus granulosus	General substrate transporter	0.0097	0.1749	0.4206
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.1301	0.1856
Echinococcus granulosus	transient receptor potential ion channel A	0.0093	0.1662	0.3991
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0425	0.0915
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0021	0.0114	0.0086
Echinococcus multilocularis	dna polymerase eta	0.0054	0.0818	0.1893
Brugia malayi	Fli-1 protein	0.0265	0.5372	0.7925
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0959	0.1346
Loa Loa (eye worm)	hypothetical protein	0.015	0.2889	0.4223
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0425	0.0549
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0425	0.0814
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0021	0.0114	0.0143
Echinococcus multilocularis	GA binding protein alpha chain	0.0087	0.1537	0.368
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0021	0.0114	0.0086
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0021	0.0116	0.0132
Onchocerca volvulus	Glucosylceramidase homolog	0.0165	0.3199	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0114	0.0086
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.005	0.0734	0.101
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0035	0.0401	0.0346
Schistosoma mansoni	coup transcription factor	0.0021	0.0114	0.0086
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0113	0.2092	0.5058
Loa Loa (eye worm)	fli-1 protein	0.0265	0.5372	0.7925
Onchocerca volvulus		0.015	0.2889	0.8995
Schistosoma mansoni	lysyl-tRNA synthetase	0.0025	0.0198	0.0211
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0021	0.0114	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0425	0.0549
Echinococcus multilocularis	polycomb protein SCMH1	0.005	0.0734	0.1683
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0021	0.0114	0.0086
Toxoplasma gondii	facilitative glucose transporter GT1	0.0113	0.2092	0.3138
Entamoeba histolytica	protein kinase, putative	0.0035	0.04	0.0855
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0075	0.1279	0.3038
Loa Loa (eye worm)	mbt repeat family protein	0.005	0.0734	0.101
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0425	0.0814
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0035	0.0401	0.0346
Trypanosoma cruzi	hexose transporter	0.0035	0.041	0.0878
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0156	0.0382
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0023	0.0156	0.022
Echinococcus multilocularis	lysyl tRNA synthetase	0.0025	0.0198	0.0352
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0425	0.0549
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.041	0.0527
Leishmania major	phosphoglycerate kinase B, cytosolic	0.0206	0.408	1
Toxoplasma gondii	phosphoglycerate kinase PGKII	0.0206	0.408	0.6205
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.3199	0.4685
Echinococcus multilocularis	calcium dependent protein kinase	0.0033	0.0354	0.074
Treponema pallidum	methylgalactoside ABC transporter, periplasmic galactose-binding protein (mglB-1)	0.0322	0.6593	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.5056	0.7455
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0023	0.0156	0.022
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0425	0.0549
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0425	0.0549
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0183	0.3593	0.3557
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0021	0.0114	0.0143
Treponema pallidum	phosphoglycerate kinase	0.0206	0.408	0.6156
Giardia lamblia	DINP protein human, muc B family	0.0023	0.0156	0.0247
Treponema pallidum	methylgalactoside ABC transporter, periplasmic galactose-binding protein (mglB-2)	0.0322	0.6593	1
Mycobacterium ulcerans	glutaminase	0.033	0.6763	1
Schistosoma mansoni	phosphoglycerate kinase	0.0206	0.408	0.5999
Trichomonas vaginalis	glucose transporter, putative	0.0035	0.041	0.0527
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0114	0.0086
Brugia malayi	RNA binding protein	0.0076	0.1301	0.1856
Schistosoma mansoni	hypothetical protein	0.0309	0.63	0.9309
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.3199	0.4685
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0156	0.0247
Schistosoma mansoni	lysyl-tRNA synthetase	0.0025	0.0198	0.0211
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0035	0.0401	0.0346
Echinococcus multilocularis	ecdysone induced protein 78C	0.0021	0.0114	0.0143
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0425	0.0477
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0425	0.0814
Brugia malayi	Cam kinase protein 1	0.0035	0.04	0.0513
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0057	0.0883	0.2055
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0156	0.0382
Chlamydia trachomatis	phosphoglycerate kinase	0.0206	0.408	1
Leishmania major	protein kinase, putative	0.0035	0.04	0.0855
Loa Loa (eye worm)	hypothetical protein	0.0206	0.408	0.5999
Brugia malayi	beta-lactamase family protein	0.0036	0.0425	0.0549
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0156	0.0382
Trypanosoma cruzi	hexose transporter, putative	0.0035	0.041	0.0878
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0425	0.0549
Brugia malayi	ImpB/MucB/SamB family protein	0.0054	0.0818	0.1136
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0056	0.0138
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0156	0.0382
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0114	0.0086
Schistosoma mansoni	glucose transport protein	0.0113	0.2092	0.3034
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0025	0.0198	0.0352
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0156	0.0382
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.5056	0.7455
Echinococcus granulosus	transient receptor potential gamma protein	0.0096	0.1732	0.4163
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0021	0.0114	0.0086
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0156	0.0382
Loa Loa (eye worm)	sugar transporter	0.0113	0.2092	0.3034
Schistosoma mansoni	RAR-like nuclear receptor	0.0021	0.0114	0.0086
Brugia malayi	Ets-domain containing protein	0.0087	0.1537	0.2208
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0021	0.0116	0.0132
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.1301	0.1856
Brugia malayi	Ets-domain containing protein	0.0087	0.1537	0.2208
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.3199	0.4685
Wolbachia endosymbiont of Brugia malayi	phosphoglycerate kinase	0.0206	0.408	1
Trypanosoma brucei	phosphoglycerate kinase, putative	0.0075	0.1279	0.3134
Schistosoma mansoni	gabp alpha	0.0087	0.1537	0.2208
Schistosoma mansoni	glucose transport protein	0.0113	0.2092	0.3034
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0248	0.0286
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.004	0.0506	0.1241
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0035	0.041	0.0878
Loa Loa (eye worm)	steroid hormone receptor	0.0021	0.0114	0.0086
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0035	0.04	0.0855
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0156	0.0247
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0087	0.1537	0.2208
Trichomonas vaginalis	DNA polymerase eta, putative	0.0023	0.0156	0.0148
Loa Loa (eye worm)	glutaminase	0.033	0.6763	1
Trypanosoma brucei	phosphoglycerate kinase	0.0206	0.408	1
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0035	0.0401	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0357	0.0449
Trypanosoma brucei	glucose transporter, putative	0.0035	0.041	0.1005
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0385	0.049
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.5056	0.7455
Toxoplasma gondii	lysine-tRNA ligase	0.0025	0.0198	0.0218
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.5056	0.7455
Echinococcus multilocularis	phosphoglycerate kinase 1	0.0206	0.408	1
Echinococcus multilocularis	SAM and MBT domain containing protein	0.005	0.0734	0.1683
Trypanosoma brucei	phosphoglycerate kinase	0.0075	0.1279	0.3134
Plasmodium falciparum	lysine--tRNA ligase	0.0025	0.0198	0.0142
Trypanosoma cruzi	3-phosphoglycerate kinase, glycosomal	0.0075	0.1279	0.3038
Brugia malayi	TAR-binding protein	0.0076	0.1301	0.1856
Trypanosoma cruzi	hexose transporter, putative	0.0035	0.041	0.0878
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0021	0.0114	0.0143
Trypanosoma brucei	glucose transporter, putative	0.0035	0.041	0.1005
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0021	0.0114	0.0086
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0023	0.0156	0.0247
Trypanosoma cruzi	DNA polymerase eta, putative	0.0038	0.0472	0.1033
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.0114	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0427	0.0552
Schistosoma mansoni	sex comb on midleg homolog	0.005	0.0734	0.101
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0057	0.0883	0.2055
Trichomonas vaginalis	conserved hypothetical protein	0.0113	0.2092	0.3034
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0425	0.0814
Entamoeba histolytica	hypothetical protein	0.0043	0.059	0.1325
Entamoeba histolytica	hypothetical protein	0.0043	0.059	0.1325
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0023	0.0156	0.0247
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0035	0.04	0.0513
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0023	0.0156	0.0148
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0251	0.5056	0.7455
Toxoplasma gondii	phosphoglycerate kinase PGKI	0.0206	0.408	0.6205
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0034	0.0385	0.0817
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.1301	0.3094
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0183	0.3593	0.5454
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0425	0.0814
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0201	0.3991	0.9778
Trichomonas vaginalis	sugar transporter, putative	0.0035	0.041	0.0527
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.004	0.0506	0.1118
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0183	0.3593	0.3557
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0034	0.0385	0.049
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0425	0.0549
Trypanosoma brucei	glucose transporter, putative	0.0035	0.041	0.1005
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0035	0.041	0.1005
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0114	0.0086
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.004	0.0506	0.0694
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0035	0.04	0.0855
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0035	0.0401	0.0346
Echinococcus granulosus	short transient receptor potential channel 6	0.0064	0.1028	0.2415
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0201	0.3991	0.9778
Leishmania major	glucose transporter, lmgt2	0.0035	0.041	0.0878
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0035	0.0401	0.0346
Echinococcus granulosus	short transient receptor potential channel 6	0.0064	0.1028	0.2415
Echinococcus granulosus	calcium dependent protein kinase	0.0033	0.0354	0.074
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0021	0.0114	0.0086
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0023	0.0156	0.0247
Trypanosoma brucei	glucose transporter, putative	0.0035	0.041	0.1005
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1264	0.1801
Trypanosoma brucei	glucose transporter, putative	0.0035	0.041	0.1005
Brugia malayi	Phosphoglycerate kinase	0.0206	0.408	0.5999
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0425	0.0814
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0035	0.0401	0.0346
Leishmania major	PAS-domain containing phosphoglycerate kinase, putative	0.0075	0.1279	0.3038
Plasmodium vivax	phosphoglycerate kinase, putative	0.0206	0.408	0.4047
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0425	0.1041
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0425	0.0915
Echinococcus granulosus	lysyl tRNA synthetase	0.0025	0.0198	0.0352
Trichomonas vaginalis	glucose transporter, putative	0.0035	0.041	0.0527
Schistosoma mansoni	thyroid hormone receptor	0.0021	0.0114	0.0086
Trichomonas vaginalis	CAMK family protein kinase	0.0035	0.04	0.0513
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0035	0.041	0.1005
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0075	0.1279	0.3038
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0425	0.0549
Brugia malayi	Sugar transporter family protein	0.0113	0.2092	0.3034
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.3199	0.4685
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.1301	0.1856
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0034	0.0385	0.049
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0425	0.0814
Loa Loa (eye worm)	hypothetical protein	0.005	0.0734	0.101
Leishmania major	DNA polymerase eta, putative	0.0054	0.0818	0.1893
Onchocerca volvulus		0.0036	0.0425	0.1007
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0425	0.0549
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0114	0.0086
Plasmodium falciparum	hexose transporter	0.0113	0.2092	0.2047
Schistosoma mansoni	glucose transport protein	0.0113	0.2092	0.3034
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0251	0.5056	0.7455
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0035	0.04	0.0513
Entamoeba histolytica	hypothetical protein	0.0043	0.059	0.1325
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0021	0.0114	0.0086
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0034	0.0385	0.0817
Plasmodium vivax	lysine--tRNA ligase, putative	0.0025	0.0198	0.0142
Brugia malayi	lysyl-tRNA synthetase	0.0025	0.0198	0.0211
Brugia malayi	mbt repeat family protein	0.005	0.0734	0.101
Leishmania major	glucose transporter, lmgt1	0.0035	0.041	0.0878
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.3199	0.4685
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0021	0.0114	0.0086
Brugia malayi	hypothetical protein	0.0043	0.059	0.0795
Schistosoma mansoni	phosphoglycerate kinase	0.0206	0.408	0.5999
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.041	0.0527
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0425	0.0549
Schistosoma mansoni	retinoic acid receptor RXR	0.0021	0.0114	0.0086
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0036	0.0427	0.092
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0114	0.0086
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0035	0.0401	0.0346
Echinococcus granulosus	tar DNA binding protein	0.0076	0.1301	0.3094
Brugia malayi	ecdysteroid receptor	0.0021	0.0114	0.0086
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0025	0.0198	0.0127
Brugia malayi	steroid hormone receptor	0.0021	0.0114	0.0086
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0021	0.0114	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0883	0.1233
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0075	0.1279	0.3038
Brugia malayi	Nuclear hormone receptor-like 1	0.0021	0.0114	0.0086
Echinococcus granulosus	ecdysone induced protein 78C	0.0021	0.0114	0.0143
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0114	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0385	0.049
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0057	0.0883	0.1233
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0198	0.0211
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.1301	0.1856
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0425	0.0814
Schistosoma mansoni	protein kinase	0.0035	0.04	0.0513
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.1301	0.1856
Schistosoma mansoni	DNA polymerase eta	0.0054	0.0818	0.1136
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0114	0.0086
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0021	0.0114	0.0086
Echinococcus granulosus	GA binding protein alpha chain	0.0087	0.1537	0.368
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0038	0.0472	0.0641
Schistosoma mansoni	nuclear hormone receptor	0.0021	0.0114	0.0086
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0035	0.041	0.1005
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.1301	0.1856

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	13.782 uM	PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	30.5756 uM	PubChem BioAssay: Tox21. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	34.6188 uM	PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	34.6188 uM	PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the NFkB signaling pathway. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	54.3719 uM	PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	54.8671 uM	PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	61.5619 uM	PubChem BioAssay: Tox21. qHTS assay for small molecule activators of the heat shock response signaling pathway. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3182608

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1869018