TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 428.333 | Formula: C19H25Cl2N4O3-
H donors: 0 H acceptors: 2 LogP: 2.99 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Clc1cccc(c1)OCCCN1CCN(CC1)c1cc(=O)n(c(=O)n1C)C.[Cl-]
InChi: 1S/C19H25ClN4O3.ClH/c1-21-17(14-18(25)22(2)19(21)26)24-10-8-23(9-11-24)7-4-12-27-16-6-3-5-15(20)13-16;/h3,5-6,13-14H,4,7-12H2,1-2H3;1H/p-1
InChiKey: MTXCRSDUBLNSJJ-UHFFFAOYSA-M

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0018	0.0072	0.1423
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0215	0.0482
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0269	0.0601
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0084	0.1843
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0015	0.0038	0.0014
Schistosoma mansoni	cpg binding protein	0.003	0.0218	0.0218
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.002	0.009	0.0065
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0068	0.0686	0.0662
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0046	0.0413	0.1045
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0038	0.0085
Echinococcus multilocularis	JmjC domain containing protein 4	0.0018	0.0072	0.0047
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.009	0.1883
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0187	0.2168	0.5768
Loa Loa (eye worm)	jmjC domain-containing protein	0.0018	0.0072	0.0125
Schistosoma mansoni	microtubule-associated protein tau	0.073	0.8888	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.024	0.0243
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.002	0.009	0.0175
Echinococcus granulosus	dna polymerase eta	0.002	0.009	0.0073
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.01	0.1086	0.2856
Brugia malayi	MH2 domain containing protein	0.0016	0.0052	0.0073
Echinococcus multilocularis	dna polymerase kappa	0.002	0.009	0.0065
Echinococcus granulosus	polycomb protein SCMH1	0.0106	0.116	0.1281
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.009	0.1883
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1342	0.3544
Echinococcus granulosus	mothers against decapentaplegic 5	0.0016	0.0052	0.003
Echinococcus granulosus	endoplasmin	0.0028	0.0192	0.0188
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0016	0.0052	0.0027
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.009	0.1673
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.024	0.0579
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0094	0.1012	0.1113
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0187	0.2168	0.5768
Toxoplasma gondii	cathepsin CPC1	0.0373	0.4466	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0015	0.004	0.009
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0084	0.0132
Onchocerca volvulus		0.0108	0.119	1
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0015	0.0038	0.0013
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0084	0.1843
Schistosoma mansoni	heat shock protein	0.0035	0.028	0.0287
Brugia malayi	jmjC domain containing protein	0.0068	0.0686	0.1778
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0068	0.0686	0.0745
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0046	0.0413	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0042	0.0363	0.0813
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0094	0.1012	0.0989
Brugia malayi	Smad1	0.0016	0.0052	0.0073
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0084	0.1514
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0015	0.0038	0.0034
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0016	0.0052	0.003
Schistosoma mansoni	smad	0.0016	0.0052	0.003
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0034	0.0269	0.0548
Schistosoma mansoni	ferritin	0.0017	0.006	0.0039
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0046	0.0413	0.0438
Brugia malayi	hypothetical protein	0.0072	0.0744	0.1934
Trichomonas vaginalis	alpha-glucosidase, putative	0.0015	0.004	0.009
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0269	0.0601
Leishmania major	heat shock protein 83-1	0.0035	0.028	0.6557
Echinococcus multilocularis	expressed protein	0.0017	0.006	0.0034
Schistosoma mansoni	sex comb on midleg homolog	0.0106	0.116	0.1281
Echinococcus multilocularis	microtubule associated protein 2	0.073	0.8888	0.8886
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0153	0.0344
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.009	0.1673
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0094	0.1012	0.1113
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.002	0.009	0.0202
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0015	0.0038	0.0328
Loa Loa (eye worm)	hypothetical protein	0.002	0.009	0.0175
Leishmania major	heat shock protein 83-1	0.0035	0.028	0.6557
Echinococcus multilocularis	dna polymerase eta	0.002	0.009	0.0065
Schistosoma mansoni	cpg binding protein	0.003	0.0218	0.0218
Echinococcus multilocularis	heat shock protein 90	0.0035	0.028	0.0255
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0018	0.0072	0.1201
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0373	0.4466	0.5011
Trichomonas vaginalis	heat shock protein, putative	0.0028	0.0192	0.043
Echinococcus multilocularis	phd:f box containing protein	0.0018	0.0072	0.0047
Schistosoma mansoni	hypothetical protein	0.0691	0.8411	0.9461
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0084	0.0059
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0015	0.004	0.009
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0198	0.0466
Echinococcus multilocularis	lysine specific demethylase 5A	0.0068	0.0686	0.0662
Trichomonas vaginalis	alpha-glucosidase, putative	0.0015	0.004	0.009
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0373	0.4466	1
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.009	0.1883
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0298	0.0667
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.0413	0.0925
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0106	0.116	0.1281
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0153	0.0344
Echinococcus granulosus	neutral alpha glucosidase AB	0.0042	0.0363	0.0381
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.0413	0.0925
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0373	0.4466	1
Plasmodium falciparum	endoplasmin, putative	0.0021	0.0113	0.0198
Echinococcus granulosus	ferritin	0.0017	0.006	0.0039
Leishmania major	heat shock protein 83-1	0.0035	0.028	0.6557
Loa Loa (eye worm)	mbt repeat family protein	0.0106	0.116	0.3056
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0106	0.116	0.9745
Brugia malayi	Endoplasmin precursor	0.0035	0.028	0.0685
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0084	0.1843
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.009	0.1673
Brugia malayi	Calcitonin receptor-like protein seb-1	0.01	0.1086	0.2856
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0018	0.0072	0.0053
Echinococcus multilocularis	ferritin	0.0017	0.006	0.0034
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0331	0.074
Trypanosoma brucei	glucosidase, putative	0.0042	0.0363	0.8742
Loa Loa (eye worm)	hypothetical protein	0.0015	0.004	0.004
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.0413	0.0925
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0015	0.0038	0.0014
Giardia lamblia	Grp94/Hsp90	0.0028	0.0192	0.0246
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0042	0.0363	0.0813
Leishmania major	heat shock protein 83-1	0.0035	0.028	0.6557
Echinococcus granulosus	phd:f box containing protein	0.0018	0.0072	0.0053
Leishmania major	heat shock protein 83-1	0.0035	0.028	0.6557
Schistosoma mansoni	endoplasmin	0.0035	0.028	0.0287
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.0028	0.0192	1
Schistosoma mansoni	phosphatidylserine receptor	0.0018	0.0072	0.0053
Schistosoma mansoni	glutaminase	0.0314	0.374	0.4192
Toxoplasma gondii	heat shock protein HSP90	0.0035	0.028	0.0573
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0094	0.1012	0.2656
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0186	0.0416
Schistosoma mansoni	heat shock protein	0.0035	0.028	0.0287
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.024	0.0579
Echinococcus granulosus	heat shock protein 90	0.0028	0.0192	0.0188
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.0028	0.0192	0.4295
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0072	0.0125
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.024	0.0215
Trichomonas vaginalis	DNA polymerase eta, putative	0.002	0.009	0.0202
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0054	0.0511	0.1095
Leishmania major	heat shock protein 83-1	0.0035	0.028	0.6557
Trichomonas vaginalis	heat shock protein, putative	0.0028	0.0192	0.043
Entamoeba histolytica	hypothetical protein	0.0072	0.0744	1
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0121	0.1342	0.132
Trypanosoma cruzi	heat shock protein 85, putative	0.0035	0.028	0.6557
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0094	0.1012	0.1113
Schistosoma mansoni	smad1 5 8 and	0.0016	0.0052	0.003
Leishmania major	heat shock protein 83-1	0.0035	0.028	0.6557
Loa Loa (eye worm)	Smad1	0.0016	0.0052	0.0073
Schistosoma mansoni	transcription factor LCR-F1	0.0072	0.0744	0.0811
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.006	0.0591	0.0638
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0373	0.4466	1
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0421	0.5066	0.5687
Brugia malayi	latrophilin 2 splice variant baaae	0.0068	0.0695	0.1802
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0269	0.0601
Toxoplasma gondii	heat shock protein 90, putative	0.0035	0.028	0.0573
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0046	0.0413	0.0389
Trichomonas vaginalis	alpha-glucosidase, putative	0.0015	0.004	0.009
Brugia malayi	jmjC domain containing protein	0.0018	0.0072	0.0125
Trichomonas vaginalis	glutaminase, putative	0.0314	0.374	0.8375
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0046	0.0413	0.5402
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0121	0.1342	0.3544
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0298	0.0667
Echinococcus multilocularis	smad	0.0016	0.0052	0.0027
Echinococcus granulosus	expressed protein	0.0017	0.006	0.0039
Schistosoma mansoni	ferritin light chain	0.0017	0.006	0.0039
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0121	0.1342	0.1486
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.009	0.1673
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.024	0.0215
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0198	0.0466
Plasmodium falciparum	heat shock protein 90	0.0035	0.028	0.0573
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.009	0.1883
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0084	0.0818
Trypanosoma brucei	heat shock protein 90, putative	0.0035	0.028	0.6644
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0042	0.0363	0.091
Loa Loa (eye worm)	heat shock protein 90	0.0035	0.028	0.0685
Echinococcus granulosus	GPCR family 2	0.0032	0.024	0.0243
Brugia malayi	mbt repeat family protein	0.0106	0.116	0.3056
Echinococcus multilocularis	lysine specific demethylase 6a	0.0018	0.0072	0.0047
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0015	0.0038	0.0328
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0072	0.0744	0.072
Leishmania major	heat shock protein 83-1	0.0035	0.028	0.6557
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0042	0.0363	0.0813
Leishmania major	heat shock protein 83-1	0.0035	0.028	0.6557
Brugia malayi	MH1 domain containing protein	0.0016	0.0052	0.0073
Trichomonas vaginalis	alpha-glucosidase, putative	0.0042	0.0363	0.0813
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0038	0.0085
Schistosoma mansoni	smad1 5 8 and	0.0016	0.0052	0.003
Brugia malayi	mbt repeat family protein	0.0106	0.116	0.3056
Schistosoma mansoni	hypothetical protein	0.0032	0.024	0.0243
Brugia malayi	heat shock protein 90	0.0035	0.028	0.0685
Echinococcus granulosus	microtubule associated protein 2	0.073	0.8888	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0269	0.0601
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0084	0.0158
Schistosoma mansoni	cpg binding protein	0.0028	0.0198	0.0195
Echinococcus granulosus	smad	0.0016	0.0052	0.003
Trypanosoma cruzi	heat shock protein 90, putative	0.0035	0.028	0.6557
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0298	0.0667
Schistosoma mansoni	apoferritin-2	0.0017	0.006	0.0039
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0153	0.0344
Treponema pallidum	heat shock protein 90	0.0028	0.0192	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0046	0.0413	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0042	0.0363	0.0813
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0022	0.0116	0.2524
Mycobacterium ulcerans	glutaminase	0.0314	0.374	1
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0042	0.0363	0.4705
Mycobacterium ulcerans	DNA polymerase IV	0.002	0.009	0.0083
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0183	0.0409
Leishmania major	heat shock protein 83-1	0.0035	0.028	0.6557
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0046	0.0413	0.5402
Echinococcus granulosus	dna polymerase kappa	0.002	0.009	0.0073
Trypanosoma brucei	unspecified product	0.002	0.009	0.1883
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0028	0.0192	0.0188
Leishmania major	heat shock protein 83-1	0.0035	0.028	0.6557
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0084	0.0066
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0018	0.0072	0.0105
Schistosoma mansoni	hypothetical protein	0.0032	0.024	0.0243
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0042	0.0363	0.0813
Loa Loa (eye worm)	transcription factor SMAD2	0.0241	0.2838	0.757
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0298	0.0667
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.002	0.009	0.0073
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0019	0.0083	0.1707
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.002	0.009	0.1673
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.009	0.1883
Schistosoma mansoni	hypothetical protein	0.0648	0.7871	0.8852
Echinococcus granulosus	histone acetyltransferase MYST2	0.0121	0.1342	0.1486
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0227	0.0509
Loa Loa (eye worm)	jmjC domain-containing protein	0.0018	0.0072	0.0125
Schistosoma mansoni	hypothetical protein	0.0068	0.0695	0.0755
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0069	0.0706	0.0768
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0018	0.0072	0.0105
Echinococcus multilocularis	geminin	0.0691	0.8411	0.8407
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0153	0.0344
Leishmania major	DNA polymerase eta, putative	0.002	0.009	0.1673
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0042	0.0363	0.0761
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0015	0.0038	0.0573
Trypanosoma brucei	Heat shock protein 83, putative	0.0035	0.028	0.6644
Echinococcus granulosus	JmjC domain containing protein 4	0.0018	0.0072	0.0053
Trypanosoma brucei	heat shock protein, putative	0.0035	0.028	0.6644
Echinococcus multilocularis	endoplasmin	0.0028	0.0192	0.0167
Loa Loa (eye worm)	MH2 domain-containing protein	0.0016	0.0052	0.0073
Trypanosoma brucei	heat shock protein, putative	0.0035	0.028	0.6644
Trypanosoma brucei	heat shock protein, putative	0.0035	0.028	0.6644
Schistosoma mansoni	apoferritin-2	0.0017	0.006	0.0039
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0187	0.2168	0.2148
Trichomonas vaginalis	alpha-glucosidase, putative	0.0015	0.004	0.009
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0036	0.0298	0.7109
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.002	0.0092	0.0075
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0373	0.4466	1
Trichomonas vaginalis	heat shock protein, putative	0.0028	0.0192	0.043
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0084	0.1728
Loa Loa (eye worm)	phosphatidylinositol 3	0.0015	0.0038	0.0034
Schistosoma mansoni	hypothetical protein	0.0032	0.024	0.0243
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0094	0.1012	0.2656
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0046	0.0413	1
Trypanosoma cruzi	Heat shock protein 83, putative	0.0035	0.028	0.6557
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0106	0.116	0.1138
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0015	0.0038	0.0573
Toxoplasma gondii	exonuclease III APE	0.0019	0.0084	0.0132
Loa Loa (eye worm)	MH1 domain-containing protein	0.0016	0.0052	0.0073
Echinococcus granulosus	Smad4	0.0016	0.0052	0.003
Schistosoma mansoni	protein phosphatase 2C	0.0018	0.0072	0.0053
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0016	0.0052	0.003
Echinococcus granulosus	heat shock protein 90	0.0035	0.028	0.0287
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0018	0.0072	0.1201
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0015	0.004	0.0209
Echinococcus granulosus	lysosomal alpha glucosidase	0.0187	0.2168	0.2418
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0016	0.0052	0.0027
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.009	0.0175
Entamoeba histolytica	heat shock protein 90, putative	0.0035	0.028	0.3542
Leishmania major	heat shock protein 83-1	0.0035	0.028	0.6557
Trypanosoma cruzi	heat shock protein 85, putative	0.0035	0.028	0.6557
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0042	0.0363	0.4705
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0015	0.004	0.009
Echinococcus granulosus	lysine specific demethylase 6a	0.0018	0.0072	0.0053
Trypanosoma brucei	heat shock protein, putative	0.0035	0.028	0.6644
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0015	0.004	0.0387
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0084	0.0066
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0046	0.0413	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0269	0.0601
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0121	0.1342	0.1486
Entamoeba histolytica	hypothetical protein	0.0072	0.0744	1
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0046	0.0413	1
Schistosoma mansoni	DNA polymerase eta	0.002	0.009	0.0073
Trypanosoma cruzi	heat shock protein 85, putative	0.0028	0.0192	0.4295
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0042	0.0363	0.091
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0069	0.0706	0.0768
Loa Loa (eye worm)	glutaminase 2	0.0314	0.374	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0363	0.8709
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.009	0.1883
Onchocerca volvulus		0.0106	0.116	0.9745
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0373	0.4466	1
Plasmodium vivax	JmjC domain containing protein	0.0018	0.0072	0.0105
Schistosoma mansoni	alpha-glucosidase	0.0161	0.1845	0.2053
Schistosoma mansoni	Smad4	0.0016	0.0052	0.003
Leishmania major	alpha glucosidase II subunit, putative	0.0042	0.0363	0.8709
Leishmania major	DNA polymerase kappa, putative	0.002	0.009	0.1673
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0072	0.0125
Entamoeba histolytica	hypothetical protein	0.0072	0.0744	1
Schistosoma mansoni	hypothetical protein	0.0072	0.0744	0.0811
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0363	0.8709
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0153	0.0343
Schistosoma mansoni	ap endonuclease	0.0019	0.0084	0.0066
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.009	0.0175
Echinococcus multilocularis	polycomb protein SCMH1	0.0106	0.116	0.1138
Trypanosoma cruzi	heat shock protein 90, putative	0.0028	0.0192	0.4295
Schistosoma mansoni	endoplasmin	0.0035	0.028	0.0287
Schistosoma mansoni	jumonji domain containing protein	0.0068	0.0686	0.0745
Leishmania major	heat shock protein 83-1	0.0035	0.028	0.6557
Giardia lamblia	DINP protein human, muc B family	0.002	0.009	0.0014
Echinococcus granulosus	lysine specific demethylase 5A	0.0069	0.0706	0.0768
Loa Loa (eye worm)	MBCTL1	0.0121	0.1342	0.3544
Brugia malayi	jmjC domain containing protein	0.0069	0.0706	0.1832
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.0028	0.0192	1
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.002	0.0092	0.0067
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.009	0.1883
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0042	0.0363	0.0339
Schistosoma mansoni	ferritin	0.0017	0.006	0.0039
Leishmania major	heat shock protein 83-1	0.0035	0.028	0.6557
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0084	0.1514
Brugia malayi	MH2 domain containing protein	0.0016	0.0052	0.0073
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0015	0.004	0.0387
Entamoeba histolytica	deoxycytidyl transferase, putative	0.002	0.009	0.0904
Echinococcus multilocularis	heat shock protein 90	0.0028	0.0192	0.0167
Schistosoma mansoni	ferritin	0.0017	0.006	0.0039
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0028	0.0192	0.0246
Plasmodium vivax	heat shock protein 86, putative	0.0035	0.028	0.0573
Trypanosoma brucei	heat shock protein, putative	0.0035	0.028	0.6644
Trypanosoma cruzi	DNA polymerase eta, putative	0.002	0.009	0.1673
Plasmodium vivax	endoplasmin, putative	0.0035	0.028	0.0573
Schistosoma mansoni	jumonji domain containing protein	0.0018	0.0072	0.0053
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0186	0.0416
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0015	0.004	0.004
Leishmania major	heat shock protein 83-1	0.0035	0.028	0.6557
Loa Loa (eye worm)	jmjC domain-containing protein	0.0069	0.0706	0.1832
Trypanosoma brucei	glycosyl hydrolase-like protein	0.0015	0.004	0.063
Giardia lamblia	GTOR	0.0046	0.0413	0.0752
Onchocerca volvulus		0.0028	0.0198	0.1487
Trichomonas vaginalis	heat shock protein, putative	0.0021	0.0113	0.0253
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0269	0.0601
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0038	0.0085
Trypanosoma brucei	heat shock protein, putative	0.0035	0.028	0.6644
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0084	0.1514
Trichomonas vaginalis	heat shock protein, putative	0.0035	0.028	0.0626
Trichomonas vaginalis	endoplasmin, putative	0.0021	0.0113	0.0253
Trichomonas vaginalis	alpha-glucosidase, putative	0.0042	0.0363	0.0813
Schistosoma mansoni	ap endonuclease	0.0019	0.0084	0.0066
Trichomonas vaginalis	alpha-glucosidase, putative	0.0042	0.0363	0.0813
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0084	0.0158
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0015	0.0038	0.0328
Trypanosoma brucei	heat shock protein, putative	0.0035	0.028	0.6644
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0373	0.4466	1
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.024	0.0579
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0186	0.0416
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0072	0.0744	0.0811
Leishmania major	heat shock protein 83-1	0.0035	0.028	0.6557
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0036	0.0298	0.7034
Onchocerca volvulus	Uncharacterized family 31 glucosidase KIAA1161 homolog	0.0015	0.004	0.0129
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0094	0.1012	0.0989
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.002	0.009	0.2308
Loa Loa (eye worm)	MH2 domain-containing protein	0.0241	0.2838	0.757
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.009	0.1883
Entamoeba histolytica	hypothetical protein	0.0072	0.0744	1
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	0.0028	0.0192	1
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.009	0.1883
Brugia malayi	MH2 domain containing protein	0.0241	0.2838	0.757
Trypanosoma brucei	heat shock protein 84, putative	0.0014	0.0025	0.0253
Brugia malayi	MH1 domain containing protein	0.0016	0.0052	0.0073
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.009	0.1883
Leishmania major	heat shock protein 83-1	0.0035	0.028	0.6557
Schistosoma mansoni	sex comb on midleg homolog	0.0106	0.116	0.1281
Schistosoma mansoni	ferritin light chain	0.0017	0.006	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0106	0.116	0.3056
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0153	0.0343
Echinococcus granulosus	SAM and MBT domain containing protein	0.0106	0.116	0.1281
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0084	0.0188
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0187	0.2168	0.2148
Trypanosoma cruzi	heat shock protein 85, putative	0.0035	0.028	0.6557
Echinococcus multilocularis	GPCR, family 2	0.0032	0.024	0.0215
Trichomonas vaginalis	ferritin, putative	0.0017	0.006	0.0133
Trypanosoma brucei	heat shock protein, putative	0.0035	0.028	0.6644
Trypanosoma brucei	heat shock protein 90, putative	0.0035	0.028	0.6644
Leishmania major	glycosyl hydrolase-like protein	0.0015	0.004	0.0387
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0695	0.1802
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0035	0.028	0.0447
Mycobacterium ulcerans	heat shock protein 90	0.0028	0.0192	0.0359
Trypanosoma cruzi	heat shock protein 90, putative	0.0021	0.0103	0.2005
Schistosoma mansoni	hypothetical protein	0.0032	0.024	0.0243
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0269	0.0601
Echinococcus multilocularis	jumonji domain containing 1A	0.0018	0.0072	0.0047
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0094	0.1012	0.1113
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0084	0.0188
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.009	0.1883
Echinococcus granulosus	geminin	0.0691	0.8411	0.9461
Echinococcus granulosus	cpg binding protein	0.003	0.0218	0.0218
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0038	0.0085
Schistosoma mansoni	ferritin	0.0017	0.006	0.0039
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.009	0.1883
Leishmania major	hypothetical protein, conserved	0.0018	0.0072	0.1201
Echinococcus multilocularis	cpg binding protein	0.003	0.0218	0.0194
Schistosoma mansoni	hypothetical protein	0.0691	0.8411	0.9461
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0042	0.0363	0.0813
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0421	0.5066	0.5053
Brugia malayi	jmjC domain containing protein	0.0018	0.0072	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0072	0.0125
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0298	0.0667
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0015	0.0038	0.0328
Mycobacterium ulcerans	DNA polymerase IV	0.002	0.009	0.0083
Entamoeba histolytica	heat shock protein 90, putative	0.0035	0.028	0.3542
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0015	0.004	0.009
Loa Loa (eye worm)	hypothetical protein	0.01	0.1086	0.2856
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0084	0.0132
Schistosoma mansoni	alpha glucosidase	0.0042	0.0363	0.0381
Echinococcus granulosus	jumonji domain containing 1A	0.0018	0.0072	0.0053
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0038	0.0085
Trichomonas vaginalis	heat shock protein, putative	0.0014	0.0025	0.0056
Schistosoma mansoni	alpha-glucosidase	0.0161	0.1845	0.2053
Loa Loa (eye worm)	hypothetical protein	0.0032	0.024	0.0579
Trypanosoma cruzi	target of rapamycin kinase 3	0.0036	0.0298	0.7034
Loa Loa (eye worm)	endoplasmin	0.0035	0.028	0.0685
Loa Loa (eye worm)	glutaminase	0.0314	0.374	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0094	0.1012	0.1113
Mycobacterium tuberculosis	Conserved hypothetical protein	0.002	0.009	0.2308
Brugia malayi	glutaminase DH11.1	0.0314	0.374	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0046	0.0413	1
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0046	0.0413	0.0438
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.024	0.0243
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0373	0.4466	1
Trypanosoma brucei	DNA polymerase eta, putative	0.002	0.009	0.1883
Loa Loa (eye worm)	phosphatidylinositol 3	0.0046	0.0413	0.1045
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0183	0.0409
Schistosoma mansoni	smad1 5 8 and	0.0016	0.0052	0.003
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.01	0.1086	0.2856
Brugia malayi	jmjC domain containing protein	0.0018	0.0072	0.0125
Schistosoma mansoni	terminal deoxycytidyl transferase	0.002	0.009	0.0073
Schistosoma mansoni	phd/f-box containing protein	0.0018	0.0072	0.0053
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0121	0.1342	0.132
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.002	0.009	0.0073
Brugia malayi	jmjC domain containing protein	0.0018	0.0072	0.0125
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.009	0.1883
Echinococcus multilocularis	Smad4	0.0016	0.0052	0.0027
Echinococcus granulosus	heat shock protein	0.0035	0.028	0.0287
Echinococcus multilocularis	heat shock protein	0.0035	0.028	0.0255
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0153	0.0343
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0018	0.0072	0.0105
Loa Loa (eye worm)	jmjC domain-containing protein	0.0018	0.0072	0.0125

Activities

Activity type	Activity value	Assay description	Source	Reference
APD75 (functional)	= 6 %	The percentage change of the duration of action potential at 75% repolarization was measured before and after the administration of the compound at 3.0 ug/mL	ChEMBL.	1527781
APD75 (functional)	= 7 %	Percentage change of the duration of action potential at 75% repolarization was measured before and after the administration of the compound at 10.0 ug/mL	ChEMBL.	1527781

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 286089

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 187285