Detailed information for compound 187366

Basic information

Technical information
  • TDR Targets ID: 187366
  • Name: 10-[(4-hydroxy-3,5-dimethylphenyl)methylidene ]anthracen-9-one
  • MW: 326.388 | Formula: C23H18O2
  • H donors: 1 H acceptors: 2 LogP: 5.33 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1c(C)cc(cc1C)C=C1c2ccccc2C(=O)c2c1cccc2
  • InChi: 1S/C23H18O2/c1-14-11-16(12-15(2)22(14)24)13-21-17-7-3-5-9-19(17)23(25)20-10-6-4-8-18(20)21/h3-13,24H,1-2H3
  • InChiKey: PQMHTJHLRWHJCL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 10-[(4-hydroxy-3,5-dimethyl-phenyl)methylene]anthracen-9-one
  • 10-[(4-hydroxy-3,5-dimethylphenyl)methylene]-9-anthracenone
  • 10-[(4-hydroxy-3,5-dimethyl-phenyl)methylidene]anthracen-9-one
  • 10-(4-hydroxy-3,5-dimethyl-benzylidene)anthracen-9-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Sus scrofa Tubulin Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) tubulin alpha chain Tubulin   445 aa 432 aa 39.8 %
Echinococcus granulosus tubulin alpha chain Tubulin   445 aa 433 aa 33.5 %
Cryptosporidium parvum alpha tubulin Tubulin   445 aa 438 aa 40.2 %
Onchocerca volvulus Tubulin   445 aa 441 aa 31.5 %
Giardia lamblia Beta tubulin Tubulin   445 aa 428 aa 88.8 %
Echinococcus granulosus tubulin beta 4A class IVa Tubulin   445 aa 381 aa 71.4 %
Trichomonas vaginalis tubulin epsilon chain, putative Tubulin   445 aa 428 aa 80.8 %
Toxoplasma gondii alpha-tubulin I, putative Tubulin   445 aa 442 aa 40.0 %
Onchocerca volvulus Tubulin   445 aa 427 aa 49.9 %
Trypanosoma brucei alpha tubulin Tubulin   445 aa 434 aa 40.8 %
Echinococcus multilocularis tubulin alpha 1C chain Tubulin   445 aa 434 aa 40.6 %
Plasmodium falciparum alpha tubulin 2 Tubulin   445 aa 434 aa 41.2 %
Echinococcus multilocularis tubulin alpha 1C chain Tubulin   445 aa 434 aa 39.9 %
Trypanosoma cruzi tubulin gamma chain Tubulin   445 aa 436 aa 33.5 %
Onchocerca volvulus Tubulin   445 aa 433 aa 39.0 %
Neospora caninum tubulin alpha chain Tubulin   445 aa 440 aa 40.5 %
Plasmodium berghei alpha tubulin 1 Tubulin   445 aa 434 aa 40.3 %
Schistosoma mansoni tubulin subunit alpha Tubulin   445 aa 439 aa 39.4 %
Trypanosoma brucei epsilon tubulin Tubulin   445 aa 446 aa 29.6 %
Plasmodium falciparum tubulin gamma chain Tubulin   445 aa 438 aa 32.6 %
Schistosoma mansoni alpha tubulin Tubulin   445 aa 436 aa 39.7 %
Echinococcus granulosus tubulin alpha 1C chain Tubulin   445 aa 434 aa 40.8 %
Schistosoma japonicum ko:K10389 tubulin gamma, putative Tubulin   445 aa 436 aa 33.9 %
Trypanosoma congolense tubulin gamma chain Tubulin   445 aa 436 aa 33.3 %
Leishmania mexicana alpha tubulin Tubulin   445 aa 434 aa 40.6 %
Plasmodium falciparum alpha tubulin 1 Tubulin   445 aa 434 aa 40.8 %
Echinococcus multilocularis tubulin delta chain Tubulin   445 aa 461 aa 26.0 %
Brugia malayi Tubulin alpha-2 chain Tubulin   445 aa 435 aa 38.6 %
Neospora caninum hypothetical protein Tubulin   445 aa 430 aa 89.1 %
Plasmodium berghei tubulin gamma chain, putative Tubulin   445 aa 438 aa 33.1 %
Leishmania major alpha tubulin Tubulin   445 aa 434 aa 40.6 %
Plasmodium vivax tubulin epsilon chain, putative Tubulin   445 aa 444 aa 28.2 %
Toxoplasma gondii beta tubulin Tubulin   445 aa 430 aa 89.1 %
Theileria parva tubulin gamma chain, putative Tubulin   445 aa 420 aa 34.3 %
Echinococcus granulosus tubulin alpha 3 chain Tubulin   445 aa 434 aa 40.1 %
Giardia lamblia Beta tubulin Tubulin   445 aa 428 aa 88.8 %
Schistosoma japonicum Tubulin beta chain, putative Tubulin   445 aa 436 aa 96.6 %
Echinococcus multilocularis tubulin gamma 1 chain Tubulin   445 aa 436 aa 34.2 %
Loa Loa (eye worm) BEN-1 protein Tubulin   445 aa 427 aa 82.4 %
Dictyostelium discoideum beta tubulin Tubulin   445 aa 432 aa 76.2 %
Trichomonas vaginalis tubulin, putative Tubulin   445 aa 428 aa 80.8 %
Plasmodium knowlesi alpha tubulin, putative Tubulin   445 aa 434 aa 40.3 %
Leishmania infantum epsilon tubulin, putative Tubulin   445 aa 475 aa 30.1 %
Entamoeba histolytica tubulin alpha-1 chain Tubulin   445 aa 439 aa 36.2 %
Echinococcus multilocularis tubulin alpha 3 chain Tubulin   445 aa 439 aa 40.3 %
Brugia malayi Tubulin beta-1 chain Tubulin   445 aa 429 aa 87.9 %
Toxoplasma gondii beta-tubulin, putative Tubulin   445 aa 430 aa 89.8 %
Leishmania mexicana alpha tubulin Tubulin   445 aa 434 aa 40.6 %
Leishmania major alpha tubulin Tubulin   445 aa 434 aa 40.6 %
Echinococcus multilocularis Tubulin alpha 1 chain Tubulin   445 aa 434 aa 40.3 %
Leishmania major alpha tubulin Tubulin   445 aa 434 aa 40.6 %
Onchocerca volvulus Tubulin   445 aa 435 aa 39.8 %
Brugia malayi tubulin alpha-2 chain Tubulin   445 aa 440 aa 38.4 %
Plasmodium vivax tubulin alpha chain, putative Tubulin   445 aa 434 aa 41.2 %
Plasmodium yoelii tubulin alpha chain Tubulin   445 aa 434 aa 40.3 %
Onchocerca volvulus 1D304 homolog Tubulin   445 aa 433 aa 40.4 %
Echinococcus granulosus tubulin alpha 3 chain Tubulin   445 aa 439 aa 40.3 %
Neospora caninum hypothetical protein Tubulin   445 aa 430 aa 89.8 %
Trypanosoma brucei gambiense alpha tubulin Tubulin   445 aa 434 aa 40.8 %
Schistosoma mansoni tubulin subunit beta Tubulin   445 aa 430 aa 95.8 %
Onchocerca volvulus Tubulin   445 aa 445 aa 36.2 %
Schistosoma mansoni tubulin subunit epsilon Tubulin   445 aa 464 aa 31.5 %
Leishmania major alpha tubulin Tubulin   445 aa 434 aa 40.6 %
Echinococcus multilocularis tubulin, beta 4A class IVa Tubulin   445 aa 381 aa 71.4 %
Brugia malayi Tubulin gamma chain Tubulin   445 aa 440 aa 31.4 %
Plasmodium falciparum tubulin epsilon chain, putative Tubulin   445 aa 461 aa 27.8 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin   445 aa 428 aa 80.6 %
Echinococcus multilocularis tubulin alpha chain Tubulin   445 aa 434 aa 40.1 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin   445 aa 434 aa 39.6 %
Echinococcus granulosus Tubulin alpha 1 chain Tubulin   445 aa 434 aa 40.8 %
Echinococcus multilocularis Tubulin beta 2C chain Tubulin   445 aa 428 aa 92.5 %
Schistosoma japonicum ko:K07374 tubulin alpha, putative Tubulin   445 aa 433 aa 40.0 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin   445 aa 434 aa 39.6 %
Babesia bovis tubulin gamma chain Tubulin   445 aa 441 aa 34.2 %
Leishmania infantum alpha tubulin Tubulin   445 aa 434 aa 40.6 %
Dictyostelium discoideum hypothetical protein Tubulin   445 aa 438 aa 38.6 %
Neospora caninum Beta-tubulin, related Tubulin   445 aa 446 aa 35.0 %
Babesia bovis tubulin alpha chain, putative Tubulin   445 aa 433 aa 40.6 %
Onchocerca volvulus Tubulin   445 aa 427 aa 82.7 %
Echinococcus multilocularis Tubulin alpha 1 chain Tubulin   445 aa 434 aa 40.8 %
Brugia malayi alpha-tubulin Tubulin   445 aa 434 aa 38.7 %
Echinococcus granulosus tubulin gamma 1 chain Tubulin   445 aa 436 aa 34.2 %
Entamoeba histolytica tubulin family protein Tubulin   445 aa 429 aa 57.8 %
Leishmania major alpha tubulin Tubulin   445 aa 434 aa 40.6 %
Giardia lamblia Epsilon tubulin Tubulin   445 aa 442 aa 27.6 %
Leishmania mexicana gamma-tubulin Tubulin   445 aa 438 aa 34.2 %
Loa Loa (eye worm) alpha-tubulin Tubulin   445 aa 440 aa 38.2 %
Trypanosoma cruzi epsilon tubulin, putative Tubulin   445 aa 456 aa 30.9 %
Entamoeba histolytica tubulin family protein Tubulin   445 aa 428 aa 56.3 %
Onchocerca volvulus Regulatory-associated protein of mTOR homolog Tubulin   445 aa 440 aa 38.6 %
Theileria parva tubulin alpha chain, putative Tubulin   445 aa 452 aa 36.7 %
Entamoeba histolytica tubulin gamma chain Tubulin   445 aa 428 aa 32.9 %
Plasmodium knowlesi tubulin gamma chain, putative Tubulin   445 aa 438 aa 33.1 %
Brugia malayi tubulin alpha chain - mouse Tubulin   445 aa 433 aa 40.0 %
Echinococcus granulosus tubulin alpha chain Tubulin   445 aa 432 aa 35.0 %
Trypanosoma brucei epsilon tubulin Tubulin   445 aa 446 aa 29.4 %
Giardia lamblia Alpha-tubulin Tubulin   445 aa 434 aa 40.3 %
Giardia lamblia Gamma tubulin Tubulin   445 aa 460 aa 32.2 %
Schistosoma japonicum Tubulin alpha-1C chain, putative Tubulin   445 aa 438 aa 38.8 %
Echinococcus multilocularis Tubulin alpha 1 chain Tubulin   445 aa 434 aa 38.9 %
Trypanosoma cruzi epsilon tubulin, putative Tubulin   445 aa 456 aa 30.9 %
Echinococcus granulosus Tubulin alpha 1 chain Tubulin   445 aa 434 aa 38.9 %
Echinococcus granulosus tubulin alpha 1C chain Tubulin   445 aa 434 aa 39.6 %
Echinococcus granulosus tubulin subunit TubB Tubulin   445 aa 441 aa 30.6 %
Drosophila melanogaster beta-Tubulin at 60D Tubulin   445 aa 435 aa 91.3 %
Leishmania major epsilon tubulin, putative Tubulin   445 aa 465 aa 30.3 %
Trichomonas vaginalis tubulin alpha chain, putative Tubulin   445 aa 428 aa 80.8 %
Echinococcus multilocularis tubulin alpha chain Tubulin   445 aa 438 aa 34.5 %
Echinococcus granulosus Tubulin beta 2C chain Tubulin   445 aa 430 aa 95.1 %
Neospora caninum tubulin alpha chain, putative Tubulin   445 aa 433 aa 30.9 %
Leishmania donovani tubulin gamma chain Tubulin   445 aa 438 aa 34.2 %
Drosophila melanogaster gamma-Tubulin at 23C Tubulin   445 aa 439 aa 34.4 %
Onchocerca volvulus Tubulin   445 aa 433 aa 40.0 %
Echinococcus multilocularis Tubulin beta 2C chain Tubulin   445 aa 430 aa 94.4 %
Loa Loa (eye worm) tubulin beta-1 chain Tubulin   445 aa 432 aa 88.4 %
Leishmania infantum gamma-tubulin Tubulin   445 aa 438 aa 34.2 %
Leishmania major alpha tubulin Tubulin   445 aa 434 aa 40.6 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin   445 aa 434 aa 39.6 %
Schistosoma japonicum Tubulin alpha chain, putative Tubulin   445 aa 457 aa 36.8 %
Entamoeba histolytica tubulin alpha chain, putative Tubulin   445 aa 439 aa 35.8 %
Trichomonas vaginalis tubulin epsilon chain, putative Tubulin   445 aa 434 aa 39.6 %
Echinococcus multilocularis tubulin subunit TubB Tubulin   445 aa 441 aa 30.6 %
Neospora caninum hypothetical protein Tubulin   445 aa 430 aa 89.1 %
Trypanosoma brucei alpha tubulin Tubulin   445 aa 434 aa 40.8 %
Trypanosoma brucei alpha tubulin Tubulin   445 aa 434 aa 40.8 %
Schistosoma mansoni tubulin subunit beta Tubulin   445 aa 430 aa 92.6 %
Brugia malayi beta-tubulin, identical Tubulin   445 aa 430 aa 90.9 %
Leishmania braziliensis gamma-tubulin Tubulin   445 aa 438 aa 34.2 %
Plasmodium knowlesi alpha-tubulin II, putative Tubulin   445 aa 434 aa 41.2 %
Cryptosporidium hominis alpha-tubulin Tubulin   445 aa 438 aa 40.2 %
Loa Loa (eye worm) tubulin beta-2A chain Tubulin   445 aa 430 aa 91.9 %
Echinococcus multilocularis tubulin alpha chain Tubulin   445 aa 433 aa 33.5 %
Loa Loa (eye worm) tubulin alpha-2 chain Tubulin   445 aa 440 aa 39.1 %
Trypanosoma brucei tubulin gamma chain Tubulin   445 aa 436 aa 33.5 %
Leishmania major alpha tubulin Tubulin   445 aa 434 aa 40.6 %
Plasmodium yoelii tubulin gamma chain Tubulin   445 aa 438 aa 32.9 %
Echinococcus granulosus peroxisome assembly protein 26 Tubulin   445 aa 438 aa 29.2 %
Plasmodium knowlesi tubulin epsilon chain, putative Tubulin   445 aa 441 aa 29.0 %
Schistosoma japonicum ko:K07374 tubulin alpha, putative Tubulin   445 aa 433 aa 39.3 %
Trypanosoma brucei epsilon tubulin Tubulin   445 aa 446 aa 29.6 %
Leishmania major alpha tubulin Tubulin   445 aa 434 aa 40.6 %
Echinococcus granulosus tubulin alpha chain Tubulin   445 aa 434 aa 40.1 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin   445 aa 434 aa 39.6 %
Toxoplasma gondii alpha tubulin TUBA1 Tubulin   445 aa 440 aa 40.5 %
Schistosoma japonicum Tubulin alpha-1 chain, putative Tubulin   445 aa 439 aa 39.4 %
Cryptosporidium hominis gamma-tubulin Tubulin   445 aa 436 aa 37.4 %
Onchocerca volvulus Tyrosine kinase homolog Tubulin   445 aa 434 aa 38.2 %
Leishmania infantum alpha tubulin Tubulin   445 aa 434 aa 40.6 %
Leishmania major alpha tubulin Tubulin   445 aa 434 aa 40.6 %
Echinococcus multilocularis hypothetical protein Tubulin   445 aa 422 aa 29.9 %
Plasmodium vivax tubulin gamma chain, putative Tubulin   445 aa 438 aa 33.1 %
Onchocerca volvulus 60S ribosomal protein L13 homolog Tubulin   445 aa 430 aa 91.9 %
Echinococcus granulosus alpha tubulin Tubulin   445 aa 422 aa 29.9 %
Plasmodium vivax tubulin alpha chain, putative Tubulin   445 aa 434 aa 40.3 %
Echinococcus granulosus Tubulin alpha 1 chain Tubulin   445 aa 434 aa 40.3 %
Trypanosoma congolense alpha tubulin Tubulin   445 aa 434 aa 40.8 %
Leishmania major alpha tubulin Tubulin   445 aa 434 aa 40.6 %
Leishmania braziliensis alpha tubulin Tubulin   445 aa 434 aa 40.3 %
Dictyostelium discoideum alpha tubulin Tubulin   445 aa 446 aa 41.0 %
Toxoplasma gondii beta-1 tubulin, putative Tubulin   445 aa 430 aa 89.1 %
Giardia lamblia Beta tubulin Tubulin   445 aa 428 aa 88.8 %
Trypanosoma brucei alpha tubulin Tubulin   445 aa 434 aa 40.8 %
Plasmodium berghei tubulin epsilon chain, putative Tubulin   445 aa 445 aa 29.4 %
Plasmodium yoelii tubulin beta chain Tubulin   445 aa 445 aa 29.7 %
Echinococcus multilocularis tubulin alpha 3 chain Tubulin   445 aa 434 aa 40.1 %
Trypanosoma brucei gambiense epsilon tubulin Tubulin   445 aa 446 aa 29.4 %
Trichomonas vaginalis tubulin gamma chain, putative Tubulin   445 aa 415 aa 33.5 %
Trypanosoma cruzi alpha tubulin, putative Tubulin   445 aa 434 aa 40.6 %
Babesia bovis tubulin, putative Tubulin   445 aa 457 aa 21.4 %
Giardia lamblia Alpha-tubulin Tubulin   445 aa 434 aa 40.3 %
Leishmania mexicana epsilon tubulin, putative Tubulin   445 aa 469 aa 30.5 %
Loa Loa (eye worm) BEN-1 protein Tubulin   445 aa 427 aa 57.1 %
Echinococcus granulosus Tubulin beta 2C chain Tubulin   445 aa 428 aa 92.3 %
Cryptosporidium parvum gamma tubulin Tubulin   445 aa 436 aa 37.4 %
Leishmania major gamma-tubulin Tubulin   445 aa 438 aa 34.0 %
Leishmania donovani epsilon tubulin, putative Tubulin   445 aa 475 aa 30.1 %
Onchocerca volvulus Tubulin   445 aa 434 aa 39.9 %
Plasmodium berghei alpha tubulin 2 Tubulin   445 aa 434 aa 41.2 %
Trypanosoma congolense epsilon tubulin Tubulin   445 aa 464 aa 29.3 %
Echinococcus multilocularis peroxisome assembly protein 26 Tubulin   445 aa 438 aa 29.0 %
Dictyostelium discoideum gamma tubulin Tubulin   445 aa 429 aa 33.8 %
Leishmania braziliensis alpha tubulin Tubulin   445 aa 434 aa 40.3 %
Leishmania major alpha tubulin Tubulin   445 aa 434 aa 40.6 %
Trypanosoma brucei gambiense gamma tubulin Tubulin   445 aa 436 aa 33.5 %
Theileria parva Tubulin alpha chain, putative Tubulin   445 aa 439 aa 39.6 %
Echinococcus multilocularis tubulin alpha Tubulin   445 aa 443 aa 30.5 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin   445 aa 434 aa 39.6 %
Leishmania mexicana beta tubulin Tubulin   445 aa 429 aa 86.2 %
Schistosoma mansoni alpha tubulin Tubulin   445 aa 434 aa 39.4 %
Echinococcus granulosus beta tubulin Tubulin   445 aa 427 aa 82.7 %
Trichomonas vaginalis tubulin alpha-1 chain, putative Tubulin   445 aa 434 aa 39.6 %
Schistosoma mansoni tubulin subunit alpha Tubulin   445 aa 434 aa 38.9 %
Echinococcus granulosus tubulin alpha Tubulin   445 aa 440 aa 30.2 %
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein Tubulin   445 aa 433 aa 30.7 %
Onchocerca volvulus Putative cytochrome c-type heme lyase Tubulin   445 aa 429 aa 87.9 %
Schistosoma mansoni tubulin subunit gamma Tubulin   445 aa 436 aa 33.5 %
Leishmania major alpha tubulin Tubulin   445 aa 434 aa 40.6 %
Leishmania braziliensis epsilon tubulin, putative Tubulin   445 aa 465 aa 29.9 %
Leishmania donovani alpha tubulin Tubulin   445 aa 434 aa 40.6 %
Onchocerca volvulus Putative methyltransferase KIAA1456 Tubulin   445 aa 426 aa 49.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0017 0 0.5
Trichomonas vaginalis tubulin alpha chain, putative 0.0017 0 0.5
Echinococcus multilocularis glycoprotein Antigen 5 0.0103 1 1
Leishmania major beta tubulin 0.0017 0 0.5
Leishmania major beta tubulin 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0103 1 1
Trypanosoma brucei epsilon tubulin 0.0017 0 0.5
Schistosoma mansoni cercarial elastase (S01 family) 0.0103 1 1
Trypanosoma brucei beta tubulin 0.0017 0 0.5
Plasmodium falciparum tubulin gamma chain 0.0017 0 0.5
Entamoeba histolytica tubulin family protein 0.0017 0 0.5
Onchocerca volvulus 0.0103 1 0.5
Entamoeba histolytica tubulin family protein 0.0017 0 0.5
Onchocerca volvulus 0.0103 1 0.5
Leishmania major beta tubulin 0.0017 0 0.5
Leishmania major beta tubulin 0.0017 0 0.5
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0103 1 1
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0103 1 1
Schistosoma mansoni hypothetical protein 0.0103 1 1
Loa Loa (eye worm) hypothetical protein 0.0103 1 1
Leishmania major alpha tubulin 0.0017 0 0.5
Schistosoma mansoni cercarial elastase (S01 family) 0.0103 1 1
Entamoeba histolytica tubulin alpha chain, putative 0.0017 0 0.5
Leishmania major alpha tubulin 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0103 1 1
Plasmodium falciparum tubulin beta chain 0.0017 0 0.5
Trichomonas vaginalis tubulin gamma chain, putative 0.0017 0 0.5
Toxoplasma gondii beta tubulin 0.0017 0 0.5
Giardia lamblia Alpha-tubulin 0.0017 0 0.5
Leishmania major gamma-tubulin 0.0017 0 0.5
Trichomonas vaginalis tubulin beta chain, putative 0.0017 0 0.5
Toxoplasma gondii alpha tubulin TUBA1 0.0017 0 0.5
Leishmania major alpha tubulin 0.0017 0 0.5
Trypanosoma brucei beta tubulin 0.0017 0 0.5
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0103 1 1
Plasmodium falciparum alpha tubulin 1 0.0017 0 0.5
Leishmania major beta tubulin 0.0017 0 0.5
Plasmodium vivax tubulin alpha chain, putative 0.0017 0 0.5
Plasmodium vivax tubulin alpha chain, putative 0.0017 0 0.5
Trichomonas vaginalis tubulin gamma chain, putative 0.0017 0 0.5
Brugia malayi hypothetical protein 0.0103 1 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0103 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.0017 0 0.5
Leishmania major alpha tubulin 0.0017 0 0.5
Leishmania major beta tubulin 0.0017 0 0.5
Brugia malayi Trypsin family protein 0.0103 1 1
Echinococcus granulosus enteropeptidase 0.0103 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.0017 0 0.5
Schistosoma mansoni cercarial elastase (S01 family) 0.0103 1 1
Leishmania major beta tubulin 0.0017 0 0.5
Leishmania major beta tubulin 0.0017 0 0.5
Toxoplasma gondii beta-tubulin, putative 0.0017 0 0.5
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0017 0 0.5
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0103 1 1
Giardia lamblia Beta tubulin 0.0017 0 0.5
Echinococcus multilocularis transmembrane protease serine 3 0.0103 1 1
Giardia lamblia Beta tubulin 0.0017 0 0.5
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0103 1 1
Echinococcus multilocularis Mastin 0.0103 1 1
Brugia malayi Trypsin family protein 0.0103 1 1
Echinococcus granulosus transmembrane protease serine 3 0.0103 1 1
Trypanosoma brucei beta tubulin 0.0017 0 0.5
Leishmania major beta tubulin 0.0017 0 0.5
Echinococcus multilocularis enteropeptidase 0.0103 1 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0103 1 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0103 1 1
Leishmania major alpha tubulin 0.0017 0 0.5
Plasmodium vivax tubulin gamma chain, putative 0.0017 0 0.5
Trypanosoma cruzi epsilon tubulin, putative 0.0017 0 0.5
Toxoplasma gondii beta-1 tubulin, putative 0.0017 0 0.5
Trypanosoma brucei alpha tubulin 0.0017 0 0.5
Trypanosoma brucei alpha tubulin 0.0017 0 0.5
Trypanosoma brucei alpha tubulin 0.0017 0 0.5
Trypanosoma cruzi beta tubulin, putative 0.0017 0 0.5
Onchocerca volvulus 0.0103 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0103 1 1
Leishmania major beta tubulin 0.0017 0 0.5
Echinococcus granulosus glycoprotein Antigen 5 0.0103 1 1
Trypanosoma brucei alpha tubulin 0.0017 0 0.5
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0103 1 1
Trypanosoma brucei epsilon tubulin 0.0017 0 0.5
Plasmodium vivax tubulin epsilon chain, putative 0.0017 0 0.5
Plasmodium falciparum alpha tubulin 2 0.0017 0 0.5
Schistosoma mansoni hypothetical protein 0.0103 1 1
Trypanosoma cruzi epsilon tubulin, putative 0.0017 0 0.5
Trichomonas vaginalis tubulin epsilon chain, putative 0.0017 0 0.5
Onchocerca volvulus 0.0103 1 0.5
Schistosoma mansoni cercarial elastase (S01 family) 0.0103 1 1
Giardia lamblia Beta tubulin 0.0017 0 0.5
Leishmania major beta tubulin 0.0017 0 0.5
Trichomonas vaginalis tubulin beta chain, putative 0.0017 0 0.5
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0103 1 1
Trypanosoma cruzi alpha tubulin, putative 0.0017 0 0.5
Trichomonas vaginalis tubulin, putative 0.0017 0 0.5
Trichomonas vaginalis tubulin beta chain, putative 0.0017 0 0.5
Trichomonas vaginalis tubulin alpha chain, putative 0.0017 0 0.5
Leishmania major beta tubulin 0.0017 0 0.5
Trypanosoma brucei beta tubulin 0.0017 0 0.5
Leishmania major beta tubulin 0.0017 0 0.5
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0103 1 1
Onchocerca volvulus 0.0103 1 0.5
Leishmania major alpha tubulin 0.0017 0 0.5
Trichomonas vaginalis tubulin gamma chain, putative 0.0017 0 0.5
Trypanosoma brucei epsilon tubulin 0.0017 0 0.5
Plasmodium falciparum tubulin epsilon chain, putative 0.0017 0 0.5
Leishmania major beta tubulin 0.0017 0 0.5
Trypanosoma brucei beta tubulin 0.0017 0 0.5
Entamoeba histolytica tubulin gamma chain 0.0017 0 0.5
Plasmodium vivax tubulin beta chain, putative 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0103 1 1
Leishmania major alpha tubulin 0.0017 0 0.5
Toxoplasma gondii alpha-tubulin I, putative 0.0017 0 0.5
Trichomonas vaginalis tubulin epsilon chain, putative 0.0017 0 0.5
Leishmania major alpha tubulin 0.0017 0 0.5
Schistosoma mansoni cercarial elastase (S01 family) 0.0103 1 1
Leishmania major alpha tubulin 0.0017 0 0.5
Brugia malayi Trypsin-like protease protein 5 0.0103 1 1
Brugia malayi Trypsin family protein 0.0103 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.0017 0 0.5
Echinococcus granulosus Mastin 0.0103 1 1
Trypanosoma cruzi tubulin gamma chain 0.0017 0 0.5
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0103 1 1
Giardia lamblia Alpha-tubulin 0.0017 0 0.5
Giardia lamblia Gamma tubulin 0.0017 0 0.5
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0103 1 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0017 0 0.5
Leishmania major beta tubulin 0.0017 0 0.5
Entamoeba histolytica tubulin alpha-1 chain 0.0017 0 0.5
Leishmania major alpha tubulin 0.0017 0 0.5
Leishmania major alpha tubulin 0.0017 0 0.5
Trichomonas vaginalis tubulin beta chain, putative 0.0017 0 0.5
Schistosoma mansoni cercarial elastase (S01 family) 0.0103 1 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0103 1 1
Leishmania major alpha tubulin 0.0017 0 0.5
Schistosoma mansoni cercarial elastase (S01 family) 0.0103 1 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0103 1 1
Leishmania major beta tubulin 0.0017 0 0.5
Mycobacterium ulcerans hypothetical protein 0.0103 1 0.5
Leishmania major epsilon tubulin, putative 0.0017 0 0.5
Leishmania major beta tubulin 0.0017 0 0.5
Trypanosoma brucei tubulin gamma chain 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0103 1 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0103 1 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0103 1 1
Loa Loa (eye worm) trypsin family protein 0.0103 1 1
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0103 1 1
Onchocerca volvulus 0.0103 1 0.5
Leishmania major beta tubulin 0.0017 0 0.5

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.8 uM In vitro inhibitory concentration against human chronic myelogenous leukemia K562 cell growth ChEMBL. 12852768
IC50 (functional) = 0.8 uM In vitro inhibitory concentration against human chronic myelogenous leukemia K562 cell growth ChEMBL. 12852768
IC50 (functional) = 0.91 uM In vitro inhibition of maximum porcine tubulin assembly rate after 20 min at 37 degrees C ChEMBL. 12852768
IC50 (functional) = 0.91 uM In vitro inhibition of maximum porcine tubulin assembly rate after 20 min at 37 degrees C ChEMBL. 12852768

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 12852768

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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