Detailed information for compound 188501

Basic information

Technical information
  • TDR Targets ID: 188501
  • Name: 5-ethyl-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)p henyl]phenyl]methyl]imidazole-4-carboxylic ac id
  • MW: 416.476 | Formula: C23H24N6O2
  • H donors: 2 H acceptors: 6 LogP: 4.33 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)O)CC
  • InChi: 1S/C23H24N6O2/c1-3-7-20-24-19(4-2)21(23(30)31)29(20)14-15-10-12-16(13-11-15)17-8-5-6-9-18(17)22-25-27-28-26-22/h5-6,8-13H,3-4,7,14H2,1-2H3,(H,30,31)(H,25,26,27,28)
  • InChiKey: OFYWYKMCRWMPPQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-ethyl-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-4-imidazolecarboxylic acid
  • 5-ethyl-2-propyl-3-[[4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylic acid
  • 5-ethyl-2-propyl-3-[4-[2-(2H-tetrazol-5-yl)phenyl]benzyl]imidazole-4-carboxylic acid
  • DMP 811
  • 139964-19-5
  • 1H-Imidazole-5-carboxylic acid, 4-ethyl-2-propyl-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-
  • 4-Ethyl-2-propyl-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-1H-imidazole-5-carboxylic acid
  • 4-Ethyl-2-propyl-1-(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methylimidazole-5-carboxylic acid
  • Dmp-811

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Angiotensin II type 2 (AT-2) receptor Starlite/ChEMBL No references
Oryctolagus cuniculus Angiotensin II type 1a (AT-1a) receptor Starlite/ChEMBL No references
Bos taurus Angiotensin II type 1a (AT-1a) receptor Starlite/ChEMBL References
Homo sapiens angiotensin II receptor, type 2 Starlite/ChEMBL No references
Homo sapiens angiotensin II receptor, type 1 Starlite/ChEMBL No references
Rattus norvegicus Angiotensin II receptor (AT-1) type-1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) neuropeptide F receptor Angiotensin II type 2 (AT-2) receptor   363 aa 356 aa 23.3 %
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor Angiotensin II type 2 (AT-2) receptor   363 aa 398 aa 18.1 %
Echinococcus granulosus pyroglutamylated rfamide peptide receptor angiotensin II receptor, type 1 359 aa 403 aa 19.1 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Angiotensin II type 1a (AT-1a) receptor   359 aa 325 aa 21.8 %
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor Angiotensin II type 1a (AT-1a) receptor   359 aa 346 aa 18.2 %
Echinococcus multilocularis allatostatin A receptor Angiotensin II type 2 (AT-2) receptor   363 aa 342 aa 24.6 %
Echinococcus granulosus pyroglutamylated rfamide peptide receptor Angiotensin II type 2 (AT-2) receptor   363 aa 398 aa 18.3 %
Echinococcus granulosus neuropeptide receptor Angiotensin II type 2 (AT-2) receptor   363 aa 306 aa 22.2 %
Echinococcus granulosus allatostatin A receptor Angiotensin II type 2 (AT-2) receptor   363 aa 340 aa 24.1 %
Schistosoma japonicum Rhodopsin, putative Angiotensin II type 2 (AT-2) receptor   363 aa 341 aa 22.0 %
Onchocerca volvulus Angiotensin II type 1a (AT-1a) receptor   359 aa 350 aa 23.1 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Angiotensin II type 2 (AT-2) receptor   363 aa 310 aa 23.5 %
Onchocerca volvulus Angiotensin II type 2 (AT-2) receptor   363 aa 305 aa 21.6 %
Onchocerca volvulus Angiotensin II type 1a (AT-1a) receptor   359 aa 399 aa 25.1 %
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor Angiotensin II type 1a (AT-1a) receptor   359 aa 362 aa 24.3 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Angiotensin II type 1a (AT-1a) receptor   359 aa 346 aa 24.9 %
Echinococcus granulosus growth hormone secretagogue receptor type 1 Angiotensin II type 1a (AT-1a) receptor   359 aa 342 aa 22.2 %
Onchocerca volvulus Angiotensin II type 2 (AT-2) receptor   363 aa 306 aa 22.5 %
Echinococcus granulosus thyrotropin releasing hormone receptor Angiotensin II type 2 (AT-2) receptor   363 aa 308 aa 22.1 %
Loa Loa (eye worm) hypothetical protein Angiotensin II type 1a (AT-1a) receptor   359 aa 329 aa 22.2 %
Onchocerca volvulus E3 ubiquitin-protein ligase rpm-1 homolog Angiotensin II type 1a (AT-1a) receptor   359 aa 339 aa 21.2 %
Echinococcus granulosus tm gpcr rhodopsin Angiotensin II type 1a (AT-1a) receptor   359 aa 315 aa 21.0 %
Onchocerca volvulus Angiotensin II type 2 (AT-2) receptor   363 aa 311 aa 23.8 %
Onchocerca volvulus Angiotensin II type 1a (AT-1a) receptor   359 aa 349 aa 25.5 %
Echinococcus granulosus pyroglutamylated rfamide peptide receptor angiotensin II receptor, type 2 363 aa 398 aa 18.3 %
Schistosoma mansoni peptide (allatostatin)-like receptor Angiotensin II type 2 (AT-2) receptor   363 aa 364 aa 20.9 %
Brugia malayi GnHR receptor homolog Angiotensin II type 1a (AT-1a) receptor   359 aa 366 aa 20.8 %
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Angiotensin II type 1a (AT-1a) receptor   359 aa 315 aa 21.0 %
Echinococcus multilocularis G-protein coupled receptor, putative Angiotensin II type 1a (AT-1a) receptor   359 aa 308 aa 22.7 %
Schistosoma mansoni adenoreceptor Angiotensin II type 2 (AT-2) receptor   363 aa 328 aa 22.0 %
Echinococcus multilocularis neuropeptide receptor Angiotensin II type 2 (AT-2) receptor   363 aa 308 aa 21.4 %
Schistosoma mansoni opsin-like receptor Angiotensin II type 1a (AT-1a) receptor   359 aa 299 aa 25.8 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Angiotensin II type 2 (AT-2) receptor   363 aa 308 aa 21.8 %
Onchocerca volvulus Angiotensin II type 1a (AT-1a) receptor   359 aa 313 aa 24.6 %
Loa Loa (eye worm) hypothetical protein Angiotensin II type 1a (AT-1a) receptor   359 aa 300 aa 28.0 %
Brugia malayi ORL1-like opioid receptor Angiotensin II type 1a (AT-1a) receptor   359 aa 314 aa 20.4 %
Brugia malayi putative neuropeptide receptor NPR1 Angiotensin II type 1a (AT-1a) receptor   359 aa 295 aa 27.1 %
Onchocerca volvulus Angiotensin II type 1a (AT-1a) receptor   359 aa 317 aa 20.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cercarial elastase (S01 family) 0.0357 0.1083 0.0507
Schistosoma mansoni cercarial elastase (S01 family) 0.0357 0.1083 0.0507
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.2861 1 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0357 0.1083 0.0507
Brugia malayi GCC2 and GCC3 family protein 0.0224 0.0607 0.0552
Echinococcus granulosus Mastin 0.0357 0.1083 0.2784
Loa Loa (eye worm) hypothetical protein 0.0224 0.0607 0.0552
Toxoplasma gondii kringle domain-containing protein 0.0537 0.1724 0.8639
Onchocerca volvulus 0.0357 0.1083 0.0507
Brugia malayi Protein kinase domain containing protein 0.0556 0.179 0.1742
Schistosoma mansoni serine/threonine protein kinase 0.1164 0.3957 0.3566
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0357 0.1083 0.2784
Loa Loa (eye worm) hypothetical protein 0.0224 0.0607 0.0552
Brugia malayi Muscle positioning protein 4 0.0224 0.0607 0.0552
Loa Loa (eye worm) hypothetical protein 0.0224 0.0607 0.0552
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0357 0.1083 0.0507
Echinococcus multilocularis tissue type plasminogen activator 0.0537 0.1724 0.443
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0587 0.19 0.1852
Schistosoma mansoni cercarial elastase (S01 family) 0.0357 0.1083 0.0507
Echinococcus granulosus laminin 0.0587 0.19 0.4882
Brugia malayi notch-like transmembrane receptor 0.0224 0.0607 0.0552
Echinococcus granulosus enteropeptidase 0.0357 0.1083 0.2784
Loa Loa (eye worm) hypothetical protein 0.0357 0.1083 0.1031
Brugia malayi EGF-like domain containing protein 0.0224 0.0607 0.0552
Loa Loa (eye worm) hypothetical protein 0.1146 0.3891 0.3855
Brugia malayi Calcium binding EGF domain containing protein 0.0224 0.0607 0.0552
Loa Loa (eye worm) hypothetical protein 0.0224 0.0607 0.0552
Brugia malayi hypothetical protein 0.0357 0.1083 0.1031
Loa Loa (eye worm) hypothetical protein 0.0224 0.0607 0.0552
Brugia malayi EGF-like domain containing protein 0.0224 0.0607 0.0552
Loa Loa (eye worm) notch protein 0.0224 0.0607 0.0552
Giardia lamblia High cysteine protein 0.0224 0.0607 0.5
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0587 0.19 0.1852
Echinococcus multilocularis protein jagged 1 0.0224 0.0607 0.1561
Loa Loa (eye worm) hypothetical protein 0.1146 0.3891 0.3855
Echinococcus multilocularis laminin 0.0587 0.19 0.4882
Brugia malayi Calcium binding EGF domain containing protein 0.0224 0.0607 0.0552
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0587 0.19 0.1852
Echinococcus granulosus glutamate receptor 2 0.0065 0.0042 0.0107
Brugia malayi Calcium binding EGF domain containing protein 0.0224 0.0607 0.0552
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0075 0.0076 0.0195
Brugia malayi EGF-like domain containing protein 0.0224 0.0607 0.0552
Schistosoma mansoni hypothetical protein 0.0537 0.1724 0.1189
Loa Loa (eye worm) TK/ROR protein kinase 0.0556 0.179 0.1742
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0537 0.1724 0.5
Loa Loa (eye worm) hypothetical protein 0.0224 0.0607 0.0552
Echinococcus multilocularis Tolloid protein 1 0.0587 0.19 0.4882
Echinococcus multilocularis glutamate receptor 2 0.007 0.0058 0.015
Echinococcus granulosus protein jagged 2 0.0224 0.0607 0.1561
Loa Loa (eye worm) hypothetical protein 0.2861 1 1
Schistosoma mansoni hypothetical protein 0.0357 0.1083 0.0507
Loa Loa (eye worm) hypothetical protein 0.0224 0.0607 0.0552
Loa Loa (eye worm) hypothetical protein 0.0587 0.19 0.1852
Mycobacterium ulcerans hypothetical protein 0.0357 0.1083 0.5
Schistosoma mansoni cercarial elastase (S01 family) 0.0357 0.1083 0.0507
Brugia malayi Protein kinase domain containing protein 0.1146 0.3891 0.3855
Onchocerca volvulus Arrow homolog 0.0587 0.19 0.1376
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0357 0.1083 0.2784
Schistosoma mansoni cercarial elastase (S01 family) 0.0357 0.1083 0.0507
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0357 0.1083 0.2784
Loa Loa (eye worm) hypothetical protein 0.2861 1 1
Leishmania major hypothetical protein, conserved 0.0537 0.1724 0.5
Brugia malayi Kringle domain containing protein 0.0537 0.1724 0.1675
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0357 0.1083 0.0507
Loa Loa (eye worm) hypothetical protein 0.0224 0.0607 0.0552
Schistosoma mansoni cercarial elastase (S01 family) 0.0357 0.1083 0.0507
Loa Loa (eye worm) hypothetical protein 0.0224 0.0607 0.0552
Echinococcus granulosus glutamate receptor 2 0.0075 0.0076 0.0195
Echinococcus multilocularis glutamate receptor 2 0.0075 0.0076 0.0195
Loa Loa (eye worm) hypothetical protein 0.0224 0.0607 0.0552
Echinococcus multilocularis slit 2 protein 0.0224 0.0607 0.1561
Echinococcus multilocularis notch 0.0224 0.0607 0.1561
Loa Loa (eye worm) hypothetical protein 0.0224 0.0607 0.0552
Loa Loa (eye worm) hypothetical protein 0.0587 0.19 0.1852
Echinococcus multilocularis neurogenic locus protein delta 0.0224 0.0607 0.1561
Brugia malayi Trypsin family protein 0.0357 0.1083 0.1031
Echinococcus granulosus neurogenic locus notch protein 4 0.0224 0.0607 0.1561
Onchocerca volvulus 0.0357 0.1083 0.0507
Loa Loa (eye worm) hypothetical protein 0.0224 0.0607 0.0552
Loa Loa (eye worm) hypothetical protein 0.0224 0.0607 0.0552
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.2861 1 1
Echinococcus multilocularis transmembrane protease serine 3 0.0357 0.1083 0.2784
Loa Loa (eye worm) TKL/MLK/LZK protein kinase 0.1146 0.3891 0.3855
Loa Loa (eye worm) hypothetical protein 0.0224 0.0607 0.0552
Echinococcus granulosus glycoprotein Antigen 5 0.0357 0.1083 0.2784
Echinococcus granulosus notch 0.0224 0.0607 0.1561
Loa Loa (eye worm) hypothetical protein 0.0224 0.0607 0.0552
Onchocerca volvulus 0.2861 1 1
Echinococcus granulosus neurogenic locus notch protein 0.0224 0.0607 0.1561
Echinococcus granulosus protein jagged 2 0.0224 0.0607 0.1561
Echinococcus multilocularis Mastin 0.0357 0.1083 0.2784
Loa Loa (eye worm) hypothetical protein 0.0224 0.0607 0.0552
Loa Loa (eye worm) hypothetical protein 0.0357 0.1083 0.1031
Loa Loa (eye worm) hypothetical protein 0.0587 0.19 0.1852
Schistosoma mansoni cercarial elastase (S01 family) 0.0357 0.1083 0.0507
Trypanosoma cruzi hypothetical protein, conserved 0.0537 0.1724 0.5
Loa Loa (eye worm) hypothetical protein 0.0357 0.1083 0.1031
Brugia malayi Calcium binding EGF domain containing protein 0.0587 0.19 0.1852
Toxoplasma gondii calcium binding egf domain-containing protein 0.0587 0.19 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0357 0.1083 0.0507
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0224 0.0607 0.0552
Toxoplasma gondii calcium binding egf domain-containing protein 0.0587 0.19 1
Brugia malayi Cadherin domain containing protein 0.0224 0.0607 0.0552
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0357 0.1083 0.0507
Echinococcus granulosus Tolloid protein 1 0.0587 0.19 0.4882
Echinococcus multilocularis protein jagged 2 0.0224 0.0607 0.1561
Echinococcus granulosus neurogenic locus notch protein 0.0224 0.0607 0.1561
Schistosoma mansoni hypothetical protein 0.0357 0.1083 0.0507
Brugia malayi Trypsin family protein 0.0357 0.1083 0.1031
Brugia malayi Trypsin-like protease protein 5 0.0357 0.1083 0.1031
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0587 0.19 0.1852
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.1146 0.3891 1
Echinococcus granulosus transmembrane protease serine 3 0.0357 0.1083 0.2784
Brugia malayi Cadherin domain containing protein 0.0224 0.0607 0.0552
Echinococcus granulosus delta-like protein 1 0.0224 0.0607 0.1561
Echinococcus multilocularis glutamate receptor 2 0.0065 0.0042 0.0107
Loa Loa (eye worm) hypothetical protein 0.0224 0.0607 0.0552
Echinococcus multilocularis fat cadherin tumor suppressor 0.0224 0.0607 0.1561
Echinococcus granulosus neurogenic locus protein delta 0.0224 0.0607 0.1561
Echinococcus multilocularis protein jagged 1 0.0224 0.0607 0.1561
Brugia malayi Delta serrate ligand family protein 0.0224 0.0607 0.0552
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0357 0.1083 0.1031
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0357 0.1083 0.2784
Echinococcus multilocularis neurogenic locus protein delta 0.0224 0.0607 0.1561
Echinococcus granulosus fibropellin Ia 0.0224 0.0607 0.1561
Echinococcus multilocularis neural cadherin 0.0224 0.0607 0.1561
Brugia malayi EGF-like domain containing protein 0.0224 0.0607 0.0552
Schistosoma mansoni cercarial elastase (S01 family) 0.0357 0.1083 0.0507
Loa Loa (eye worm) hypothetical protein 0.0224 0.0607 0.0552
Brugia malayi Fibulin-1 precursor 0.0587 0.19 0.1852
Brugia malayi Trypsin family protein 0.0357 0.1083 0.1031
Loa Loa (eye worm) hypothetical protein 0.0357 0.1083 0.1031
Schistosoma mansoni egf-like domain protein 0.0587 0.19 0.1376
Plasmodium falciparum cysteine repeat modular protein 1 0.0537 0.1724 0.5
Echinococcus multilocularis fibropellin Ia 0.0224 0.0607 0.1561
Schistosoma mansoni cercarial elastase (S01 family) 0.0357 0.1083 0.0507
Onchocerca volvulus 0.0537 0.1724 0.1189
Onchocerca volvulus 0.0357 0.1083 0.0507
Brugia malayi EGF-like domain containing protein 0.0224 0.0607 0.0552
Loa Loa (eye worm) hypothetical protein 0.0224 0.0607 0.0552
Brugia malayi EGF-like domain containing protein 0.0224 0.0607 0.0552
Loa Loa (eye worm) hypothetical protein 0.0224 0.0607 0.0552
Onchocerca volvulus 0.2504 0.8727 0.8645
Echinococcus granulosus protein jagged 1 0.0224 0.0607 0.1561
Onchocerca volvulus 0.0357 0.1083 0.0507
Loa Loa (eye worm) hypothetical protein 0.0587 0.19 0.1852
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0357 0.1083 0.0507
Echinococcus granulosus protein jagged 1 0.0224 0.0607 0.1561
Schistosoma mansoni cercarial elastase (S01 family) 0.0357 0.1083 0.0507
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.1146 0.3891 1
Echinococcus multilocularis neurogenic locus notch protein 4 0.0224 0.0607 0.1561
Loa Loa (eye worm) trypsin family protein 0.0357 0.1083 0.1031
Echinococcus multilocularis neurogenic locus notch protein 0.0224 0.0607 0.1561
Loa Loa (eye worm) hypothetical protein 0.0357 0.1083 0.1031
Onchocerca volvulus 0.0357 0.1083 0.0507
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0075 0.0076 0.0195
Loa Loa (eye worm) hypothetical protein 0.0224 0.0607 0.0552
Echinococcus multilocularis glycoprotein Antigen 5 0.0357 0.1083 0.2784
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0587 0.19 0.1376
Loa Loa (eye worm) Notch2 0.0224 0.0607 0.0552
Echinococcus multilocularis fibrillin 1 0.0587 0.19 0.4882
Echinococcus multilocularis neurogenic locus notch protein 0.0224 0.0607 0.1561
Echinococcus multilocularis enteropeptidase 0.0357 0.1083 0.2784
Echinococcus granulosus slit 2 protein 0.0224 0.0607 0.1561
Echinococcus granulosus tissue type plasminogen activator 0.0537 0.1724 0.443
Loa Loa (eye worm) hypothetical protein 0.0224 0.0607 0.0552
Loa Loa (eye worm) hypothetical protein 0.0537 0.1724 0.1675
Brugia malayi EGF-like domain containing protein 0.0224 0.0607 0.0552
Echinococcus granulosus neural cadherin 0.0224 0.0607 0.1561
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0357 0.1083 0.0507
Loa Loa (eye worm) hypothetical protein 0.0587 0.19 0.1852

Activities

Activity type Activity value Assay description Source Reference
ED30 (functional) = 0.005 mg kg-1 Antihypertensive potency expressed as effective dose (iv) that lowers the mean arterial blood pressure by 30 mm Hg in renal hypertensive rats. ChEMBL. No reference
ED30 (functional) = 0.005 mg kg-1 Antihypertensive activity of compound was measured in renal hypertensive rat after iv administration ChEMBL. No reference
ED30 (functional) = 0.005 mg kg-1 Intravenous effective dose of the compound required for lowering blood pressure in renal hypertensive rats (RHR) ChEMBL. 8576904
ED30 (functional) = 0.03 mg kg-1 Oral antihypertensive potency expressed as effective dose that lowers the mean arterial blood pressure by 30 mm Hg in renal hypertensive rats ChEMBL. No reference
ED30 (functional) = 0.03 mg kg-1 Antihypertensive activity of compound was measured in renal hypertensive rat after oral administration ChEMBL. No reference
ED30 (functional) = 0.03 mg kg-1 Oral effective dose of the compound required for lowering blood pressure in renal hypertensive rats (RHR) ChEMBL. 8576904
F (ADMET) = 8 % Oral bioavailability in rat ChEMBL. 8576904
F (ADMET) = 13 % Oral bioavailability in dog ChEMBL. 8576904
F (ADMET) = 15 % Oral bioavailability ChEMBL. No reference
IC50 (binding) = 6 nM Binding affinity for Angiotensin II receptor, type 1 ChEMBL. No reference
IC50 (binding) = 6 nM Inhibitory activity against Angiotensin II receptor type 1 in rat adrenal membrane ChEMBL. 8576904
IC50 (binding) = 6 nM Binding affinity for Angiotensin II receptor, type 1 ChEMBL. No reference
IC50 (binding) = 6 nM In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta ChEMBL. No reference
IC50 (binding) = 6 nM Inhibitory activity against Angiotensin II receptor type 1 in rat adrenal membrane ChEMBL. 8576904
IC50 (binding) = 12 nM In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex ChEMBL. 8568823
IC50 (binding) = 12 nM In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex ChEMBL. 8568823
IC50 (binding) > 1000 nM Binding affinity for angiotensin II AT-2 receptor ChEMBL. No reference
IC50 (binding) > 1000 nM Binding affinity for angiotensin II AT-2 receptor ChEMBL. No reference
IC50 (binding) > 1000 nM In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain ChEMBL. No reference
ID50 (functional) = 0.019 mg kg-1 In vivo inhibitory activity against angiotensin II induced pressor response in anesthetized normotensive rats ChEMBL. 8568823
ID50 (functional) = 0.019 mg kg-1 In vivo inhibitory activity against angiotensin II induced pressor response in anesthetized normotensive rats ChEMBL. 8568823

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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