TDR Targets

Basic information

Technical information

TDR Targets ID: 188501
Name: 5-ethyl-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)p henyl]phenyl]methyl]imidazole-4-carboxylic ac id
MW: 416.476 | Formula: C23H24N6O2
H donors: 2 H acceptors: 6 LogP: 4.33 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)O)CC
InChi: 1S/C23H24N6O2/c1-3-7-20-24-19(4-2)21(23(30)31)29(20)14-15-10-12-16(13-11-15)17-8-5-6-9-18(17)22-25-27-28-26-22/h5-6,8-13H,3-4,7,14H2,1-2H3,(H,30,31)(H,25,26,27,28)
InChiKey: OFYWYKMCRWMPPQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-ethyl-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-4-imidazolecarboxylic acid
5-ethyl-2-propyl-3-[[4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylic acid
5-ethyl-2-propyl-3-[4-[2-(2H-tetrazol-5-yl)phenyl]benzyl]imidazole-4-carboxylic acid
DMP 811
139964-19-5
1H-Imidazole-5-carboxylic acid, 4-ethyl-2-propyl-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-
4-Ethyl-2-propyl-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-1H-imidazole-5-carboxylic acid
4-Ethyl-2-propyl-1-(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methylimidazole-5-carboxylic acid
Dmp-811

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Angiotensin II receptor (AT-1) type-1	Starlite/ChEMBL	References
Bos taurus	Angiotensin II type 1a (AT-1a) receptor	Starlite/ChEMBL	References
Homo sapiens	angiotensin II receptor, type 2	Starlite/ChEMBL	No references
Homo sapiens	angiotensin II receptor, type 1	Starlite/ChEMBL	No references
Oryctolagus cuniculus	Angiotensin II type 1a (AT-1a) receptor	Starlite/ChEMBL	No references
Rattus norvegicus	Angiotensin II type 2 (AT-2) receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus		Angiotensin II type 2 (AT-2) receptor	363 aa	305 aa	21.6 %
Brugia malayi	ORL1-like opioid receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	314 aa	20.4 %
Schistosoma mansoni	peptide (allatostatin)-like receptor	Angiotensin II type 2 (AT-2) receptor	363 aa	364 aa	20.9 %
Loa Loa (eye worm)	hypothetical protein	Angiotensin II type 1a (AT-1a) receptor	359 aa	329 aa	22.2 %
Schistosoma mansoni	adenoreceptor	Angiotensin II type 2 (AT-2) receptor	363 aa	328 aa	22.0 %
Schistosoma mansoni	opsin-like receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	299 aa	25.8 %
Echinococcus multilocularis	G-protein coupled receptor, putative	Angiotensin II type 1a (AT-1a) receptor	359 aa	308 aa	22.7 %
Brugia malayi	GnHR receptor homolog	Angiotensin II type 1a (AT-1a) receptor	359 aa	366 aa	20.8 %
Echinococcus granulosus	neuropeptide receptor	Angiotensin II type 2 (AT-2) receptor	363 aa	306 aa	22.2 %
Schistosoma japonicum	Rhodopsin, putative	Angiotensin II type 2 (AT-2) receptor	363 aa	341 aa	22.0 %
Echinococcus granulosus	allatostatin A receptor	Angiotensin II type 2 (AT-2) receptor	363 aa	340 aa	24.1 %
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	Angiotensin II type 2 (AT-2) receptor	363 aa	398 aa	18.3 %
Onchocerca volvulus		Angiotensin II type 1a (AT-1a) receptor	359 aa	349 aa	25.5 %
Onchocerca volvulus		Angiotensin II type 1a (AT-1a) receptor	359 aa	317 aa	20.5 %
Loa Loa (eye worm)	hypothetical protein	Angiotensin II type 1a (AT-1a) receptor	359 aa	300 aa	28.0 %
Onchocerca volvulus		Angiotensin II type 1a (AT-1a) receptor	359 aa	399 aa	25.1 %
Brugia malayi	putative neuropeptide receptor NPR1	Angiotensin II type 1a (AT-1a) receptor	359 aa	295 aa	27.1 %
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	angiotensin II receptor, type 2	363 aa	398 aa	18.3 %
Onchocerca volvulus	E3 ubiquitin-protein ligase rpm-1 homolog	Angiotensin II type 1a (AT-1a) receptor	359 aa	339 aa	21.2 %
Echinococcus multilocularis	allatostatin A receptor	Angiotensin II type 2 (AT-2) receptor	363 aa	342 aa	24.6 %
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	362 aa	24.3 %
Onchocerca volvulus		Angiotensin II type 1a (AT-1a) receptor	359 aa	350 aa	23.1 %
Echinococcus multilocularis	neuropeptide receptor	Angiotensin II type 2 (AT-2) receptor	363 aa	308 aa	21.4 %
Loa Loa (eye worm)	neuropeptide F receptor	Angiotensin II type 2 (AT-2) receptor	363 aa	356 aa	23.3 %
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	Angiotensin II type 1a (AT-1a) receptor	359 aa	315 aa	21.0 %
Onchocerca volvulus		Angiotensin II type 2 (AT-2) receptor	363 aa	311 aa	23.8 %
Schistosoma japonicum	ko:K04135 adrenergic receptor, alpha 1a, putative	Angiotensin II type 1a (AT-1a) receptor	359 aa	346 aa	24.9 %
Schistosoma japonicum	ko:K04209 neuropeptide Y receptor, invertebrate, putative	Angiotensin II type 2 (AT-2) receptor	363 aa	310 aa	23.5 %
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	346 aa	18.2 %
Onchocerca volvulus		Angiotensin II type 2 (AT-2) receptor	363 aa	306 aa	22.5 %
Echinococcus granulosus	thyrotropin releasing hormone receptor	Angiotensin II type 2 (AT-2) receptor	363 aa	308 aa	22.1 %
Schistosoma japonicum	ko:K04134 cholinergic receptor, invertebrate, putative	Angiotensin II type 1a (AT-1a) receptor	359 aa	325 aa	21.8 %
Onchocerca volvulus		Angiotensin II type 1a (AT-1a) receptor	359 aa	313 aa	24.6 %
Echinococcus multilocularis	thyrotropin releasing hormone receptor	Angiotensin II type 2 (AT-2) receptor	363 aa	308 aa	21.8 %
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	Angiotensin II type 2 (AT-2) receptor	363 aa	398 aa	18.1 %
Echinococcus granulosus	growth hormone secretagogue receptor type 1	Angiotensin II type 1a (AT-1a) receptor	359 aa	342 aa	22.2 %
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	angiotensin II receptor, type 1	359 aa	403 aa	19.1 %
Echinococcus granulosus	tm gpcr rhodopsin	Angiotensin II type 1a (AT-1a) receptor	359 aa	315 aa	21.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0357	0.1083	0.0507
Echinococcus granulosus	glycoprotein Antigen 5	0.0357	0.1083	0.2784
Echinococcus granulosus	neurogenic locus notch protein 4	0.0224	0.0607	0.1561
Loa Loa (eye worm)	hypothetical protein	0.0224	0.0607	0.0552
Echinococcus granulosus	laminin	0.0587	0.19	0.4882
Schistosoma mansoni	cercarial elastase (S01 family)	0.0357	0.1083	0.0507
Loa Loa (eye worm)	notch protein	0.0224	0.0607	0.0552
Brugia malayi	EGF-like domain containing protein	0.0224	0.0607	0.0552
Echinococcus multilocularis	notch	0.0224	0.0607	0.1561
Echinococcus granulosus	neurogenic locus notch protein	0.0224	0.0607	0.1561
Brugia malayi	Kringle domain containing protein	0.0537	0.1724	0.1675
Loa Loa (eye worm)	hypothetical protein	0.1146	0.3891	0.3855
Echinococcus granulosus	neural cadherin	0.0224	0.0607	0.1561
Loa Loa (eye worm)	hypothetical protein	0.0224	0.0607	0.0552
Brugia malayi	Calcium binding EGF domain containing protein	0.0224	0.0607	0.0552
Loa Loa (eye worm)	hypothetical protein	0.0224	0.0607	0.0552
Brugia malayi	Cadherin domain containing protein	0.0224	0.0607	0.0552
Echinococcus multilocularis	glutamate receptor 2	0.0075	0.0076	0.0195
Plasmodium falciparum	cysteine repeat modular protein 1	0.0537	0.1724	0.5
Brugia malayi	Trypsin family protein	0.0357	0.1083	0.1031
Brugia malayi	Protein kinase domain containing protein	0.1146	0.3891	0.3855
Loa Loa (eye worm)	hypothetical protein	0.0224	0.0607	0.0552
Echinococcus multilocularis	neurogenic locus protein delta	0.0224	0.0607	0.1561
Schistosoma mansoni	cercarial elastase (S01 family)	0.0357	0.1083	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0357	0.1083	0.1031
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0357	0.1083	0.0507
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0357	0.1083	0.0507
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0357	0.1083	0.1031
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.1146	0.3891	1
Echinococcus granulosus	transmembrane protease serine 3	0.0357	0.1083	0.2784
Loa Loa (eye worm)	hypothetical protein	0.0587	0.19	0.1852
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.0587	0.19	0.1376
Echinococcus multilocularis	protein jagged 2	0.0224	0.0607	0.1561
Brugia malayi	Cadherin domain containing protein	0.0224	0.0607	0.0552
Echinococcus multilocularis	Tolloid protein 1	0.0587	0.19	0.4882
Echinococcus multilocularis	neural cadherin	0.0224	0.0607	0.1561
Loa Loa (eye worm)	hypothetical protein	0.0224	0.0607	0.0552
Mycobacterium ulcerans	hypothetical protein	0.0357	0.1083	0.5
Schistosoma mansoni	cercarial elastase (S01 family)	0.0357	0.1083	0.0507
Echinococcus multilocularis	protein jagged 1	0.0224	0.0607	0.1561
Echinococcus granulosus	delta-like protein 1	0.0224	0.0607	0.1561
Schistosoma mansoni	cercarial elastase (S01 family)	0.0357	0.1083	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0224	0.0607	0.0552
Echinococcus granulosus	neurogenic locus notch protein	0.0224	0.0607	0.1561
Schistosoma mansoni	cercarial elastase (S01 family)	0.0357	0.1083	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0224	0.0607	0.0552
Echinococcus granulosus	slit 2 protein	0.0224	0.0607	0.1561
Loa Loa (eye worm)	Notch2	0.0224	0.0607	0.0552
Echinococcus granulosus	tissue type plasminogen activator	0.0537	0.1724	0.443
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0357	0.1083	0.2784
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0224	0.0607	0.0552
Echinococcus granulosus	glutamate receptor 2	0.0065	0.0042	0.0107
Echinococcus granulosus	Tolloid protein 1	0.0587	0.19	0.4882
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0357	0.1083	0.2784
Brugia malayi	EGF-like domain containing protein	0.0224	0.0607	0.0552
Loa Loa (eye worm)	hypothetical protein	0.0224	0.0607	0.0552
Loa Loa (eye worm)	hypothetical protein	0.0587	0.19	0.1852
Schistosoma mansoni	cercarial elastase (S01 family)	0.0357	0.1083	0.0507
Onchocerca volvulus		0.0357	0.1083	0.0507
Echinococcus granulosus	protein jagged 1	0.0224	0.0607	0.1561
Loa Loa (eye worm)	hypothetical protein	0.0357	0.1083	0.1031
Schistosoma mansoni	hypothetical protein	0.0357	0.1083	0.0507
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0357	0.1083	0.2784
Loa Loa (eye worm)	hypothetical protein	0.0224	0.0607	0.0552
Brugia malayi	Fibulin-1 precursor	0.0587	0.19	0.1852
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0357	0.1083	0.0507
Echinococcus granulosus	protein jagged 1	0.0224	0.0607	0.1561
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0224	0.0607	0.1561
Echinococcus granulosus	enteropeptidase	0.0357	0.1083	0.2784
Echinococcus granulosus	neurogenic locus protein delta	0.0224	0.0607	0.1561
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0587	0.19	1
Brugia malayi	Muscle positioning protein 4	0.0224	0.0607	0.0552
Echinococcus multilocularis	neurogenic locus protein delta	0.0224	0.0607	0.1561
Schistosoma mansoni	serine/threonine protein kinase	0.1164	0.3957	0.3566
Brugia malayi	Calcium binding EGF domain containing protein	0.0224	0.0607	0.0552
Brugia malayi	hypothetical protein	0.0357	0.1083	0.1031
Brugia malayi	Trypsin-like protease protein 5	0.0357	0.1083	0.1031
Loa Loa (eye worm)	hypothetical protein	0.0224	0.0607	0.0552
Loa Loa (eye worm)	hypothetical protein	0.0224	0.0607	0.0552
Echinococcus granulosus	protein jagged 2	0.0224	0.0607	0.1561
Schistosoma mansoni	cercarial elastase (S01 family)	0.0357	0.1083	0.0507
Onchocerca volvulus		0.0537	0.1724	0.1189
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0537	0.1724	0.5
Loa Loa (eye worm)	hypothetical protein	0.0357	0.1083	0.1031
Trypanosoma cruzi	hypothetical protein, conserved	0.0537	0.1724	0.5
Echinococcus granulosus	notch	0.0224	0.0607	0.1561
Loa Loa (eye worm)	hypothetical protein	0.0587	0.19	0.1852
Schistosoma mansoni	egf-like domain protein	0.0587	0.19	0.1376
Loa Loa (eye worm)	hypothetical protein	0.0357	0.1083	0.1031
Loa Loa (eye worm)	hypothetical protein	0.0224	0.0607	0.0552
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.2861	1	1
Onchocerca volvulus		0.0357	0.1083	0.0507
Toxoplasma gondii	kringle domain-containing protein	0.0537	0.1724	0.8639
Loa Loa (eye worm)	low-density lipoprotein receptor repeat class B containing protein	0.0587	0.19	0.1852
Echinococcus multilocularis	glutamate receptor 2	0.007	0.0058	0.015
Echinococcus multilocularis	tissue type plasminogen activator	0.0537	0.1724	0.443
Loa Loa (eye worm)	hypothetical protein	0.0587	0.19	0.1852
Loa Loa (eye worm)	hypothetical protein	0.0224	0.0607	0.0552
Echinococcus multilocularis	transmembrane protease serine 3	0.0357	0.1083	0.2784
Echinococcus multilocularis	enteropeptidase	0.0357	0.1083	0.2784
Onchocerca volvulus		0.0357	0.1083	0.0507
Loa Loa (eye worm)	trypsin family protein	0.0357	0.1083	0.1031
Brugia malayi	EGF-like domain containing protein	0.0224	0.0607	0.0552
Onchocerca volvulus		0.0357	0.1083	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0224	0.0607	0.0552
Echinococcus granulosus	fibropellin Ia	0.0224	0.0607	0.1561
Loa Loa (eye worm)	hypothetical protein	0.0224	0.0607	0.0552
Brugia malayi	EGF-like domain containing protein	0.0224	0.0607	0.0552
Onchocerca volvulus		0.2504	0.8727	0.8645
Brugia malayi	Calcium binding EGF domain containing protein	0.0587	0.19	0.1852
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0224	0.0607	0.1561
Echinococcus multilocularis	neurogenic locus notch protein	0.0224	0.0607	0.1561
Echinococcus granulosus	protein jagged 2	0.0224	0.0607	0.1561
Schistosoma mansoni	cercarial elastase (S01 family)	0.0357	0.1083	0.0507
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0357	0.1083	0.2784
Brugia malayi	EGF-like domain containing protein	0.0224	0.0607	0.0552
Loa Loa (eye worm)	hypothetical protein	0.0224	0.0607	0.0552
Echinococcus multilocularis	protein jagged 1	0.0224	0.0607	0.1561
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0357	0.1083	0.0507
Leishmania major	hypothetical protein, conserved	0.0537	0.1724	0.5
Echinococcus multilocularis	neurogenic locus notch protein	0.0224	0.0607	0.1561
Brugia malayi	Low-density lipoprotein receptor repeat class B containing protein	0.0587	0.19	0.1852
Schistosoma mansoni	cercarial elastase (S01 family)	0.0357	0.1083	0.0507
Brugia malayi	notch-like transmembrane receptor	0.0224	0.0607	0.0552
Onchocerca volvulus		0.2861	1	1
Loa Loa (eye worm)	hypothetical protein	0.0587	0.19	0.1852
Brugia malayi	Protein kinase domain containing protein	0.0556	0.179	0.1742
Brugia malayi	Trypsin family protein	0.0357	0.1083	0.1031
Schistosoma mansoni	hypothetical protein	0.0537	0.1724	0.1189
Loa Loa (eye worm)	hypothetical protein	0.0224	0.0607	0.0552
Echinococcus multilocularis	glycoprotein Antigen 5	0.0357	0.1083	0.2784
Onchocerca volvulus	Arrow homolog	0.0587	0.19	0.1376
Echinococcus multilocularis	glutamate receptor 2	0.0065	0.0042	0.0107
Schistosoma mansoni	cercarial elastase (S01 family)	0.0357	0.1083	0.0507
Brugia malayi	EGF-like domain containing protein	0.0224	0.0607	0.0552
Loa Loa (eye worm)	hypothetical protein	0.0357	0.1083	0.1031
Loa Loa (eye worm)	TK/ROR protein kinase	0.0556	0.179	0.1742
Loa Loa (eye worm)	hypothetical protein	0.0537	0.1724	0.1675
Loa Loa (eye worm)	hypothetical protein	0.2861	1	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0357	0.1083	0.0507
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0075	0.0076	0.0195
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0587	0.19	1
Loa Loa (eye worm)	hypothetical protein	0.0224	0.0607	0.0552
Brugia malayi	Delta serrate ligand family protein	0.0224	0.0607	0.0552
Loa Loa (eye worm)	hypothetical protein	0.1146	0.3891	0.3855
Echinococcus multilocularis	slit 2 protein	0.0224	0.0607	0.1561
Brugia malayi	GCC2 and GCC3 family protein	0.0224	0.0607	0.0552
Loa Loa (eye worm)	hypothetical protein	0.0224	0.0607	0.0552
Loa Loa (eye worm)	TKL/MLK/LZK protein kinase	0.1146	0.3891	0.3855
Loa Loa (eye worm)	hypothetical protein	0.2861	1	1
Echinococcus granulosus	glutamate receptor 2	0.0075	0.0076	0.0195
Onchocerca volvulus		0.0357	0.1083	0.0507
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.2861	1	1
Brugia malayi	EGF-like domain containing protein	0.0224	0.0607	0.0552
Echinococcus multilocularis	fibropellin Ia	0.0224	0.0607	0.1561
Brugia malayi	Trypsin family protein	0.0357	0.1083	0.1031
Echinococcus granulosus	Mastin	0.0357	0.1083	0.2784
Loa Loa (eye worm)	hypothetical protein	0.0224	0.0607	0.0552
Brugia malayi	Calcium binding EGF domain containing protein	0.0224	0.0607	0.0552
Loa Loa (eye worm)	multiple epidermal growth factor-like domains 6	0.0587	0.19	0.1852
Echinococcus multilocularis	fibrillin 1	0.0587	0.19	0.4882
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0075	0.0076	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0224	0.0607	0.0552
Echinococcus multilocularis	laminin	0.0587	0.19	0.4882
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.1146	0.3891	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0357	0.1083	0.0507
Echinococcus multilocularis	Mastin	0.0357	0.1083	0.2784
Giardia lamblia	High cysteine protein	0.0224	0.0607	0.5
Loa Loa (eye worm)	hypothetical protein	0.0224	0.0607	0.0552
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0357	0.1083	0.0507
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.0587	0.19	0.1852

Activities

Activity type	Activity value	Assay description	Source	Reference
ED30 (functional)	= 0.005 mg kg-1	Antihypertensive potency expressed as effective dose (iv) that lowers the mean arterial blood pressure by 30 mm Hg in renal hypertensive rats.	ChEMBL.	No reference
ED30 (functional)	= 0.005 mg kg-1	Antihypertensive activity of compound was measured in renal hypertensive rat after iv administration	ChEMBL.	No reference
ED30 (functional)	= 0.005 mg kg-1	Intravenous effective dose of the compound required for lowering blood pressure in renal hypertensive rats (RHR)	ChEMBL.	8576904
ED30 (functional)	= 0.03 mg kg-1	Oral antihypertensive potency expressed as effective dose that lowers the mean arterial blood pressure by 30 mm Hg in renal hypertensive rats	ChEMBL.	No reference
ED30 (functional)	= 0.03 mg kg-1	Antihypertensive activity of compound was measured in renal hypertensive rat after oral administration	ChEMBL.	No reference
ED30 (functional)	= 0.03 mg kg-1	Oral effective dose of the compound required for lowering blood pressure in renal hypertensive rats (RHR)	ChEMBL.	8576904
F (ADMET)	= 8 %	Oral bioavailability in rat	ChEMBL.	8576904
F (ADMET)	= 13 %	Oral bioavailability in dog	ChEMBL.	8576904
F (ADMET)	= 15 %	Oral bioavailability	ChEMBL.	No reference
IC50 (binding)	= 6 nM	Binding affinity for Angiotensin II receptor, type 1	ChEMBL.	No reference
IC50 (binding)	= 6 nM	Inhibitory activity against Angiotensin II receptor type 1 in rat adrenal membrane	ChEMBL.	8576904
IC50 (binding)	= 6 nM	Binding affinity for Angiotensin II receptor, type 1	ChEMBL.	No reference
IC50 (binding)	= 6 nM	In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta	ChEMBL.	No reference
IC50 (binding)	= 6 nM	Inhibitory activity against Angiotensin II receptor type 1 in rat adrenal membrane	ChEMBL.	8576904
IC50 (binding)	= 12 nM	In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex	ChEMBL.	8568823
IC50 (binding)	= 12 nM	In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex	ChEMBL.	8568823
IC50 (binding)	> 1000 nM	Binding affinity for angiotensin II AT-2 receptor	ChEMBL.	No reference
IC50 (binding)	> 1000 nM	Binding affinity for angiotensin II AT-2 receptor	ChEMBL.	No reference
IC50 (binding)	> 1000 nM	In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain	ChEMBL.	No reference
ID50 (functional)	= 0.019 mg kg-1	In vivo inhibitory activity against angiotensin II induced pressor response in anesthetized normotensive rats	ChEMBL.	8568823
ID50 (functional)	= 0.019 mg kg-1	In vivo inhibitory activity against angiotensin II induced pressor response in anesthetized normotensive rats	ChEMBL.	8568823

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

Search by CAS
ChEMBL: CHEMBL115021
PubChem: 3081289

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 188501