Detailed information for compound 1893287

Basic information

Technical information
  • TDR Targets ID: 1893287
  • Name: [(6R,8S,9R,10S,11S,13S,14S,17R)-17-(2-acetylo xyacetyl)-6,9-difluoro-11-hydroxy-10,13-dimet hyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclo penta[a]phenanthren-17-yl] acetate
  • MW: 480.498 | Formula: C25H30F2O7
  • H donors: 1 H acceptors: 5 LogP: 2.11 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)O[C@@]1(CC[C@@H]2[C@]1(C)C[C@H](O)[C@]1([C@H]2C[C@H](C2=CC(=O)C=C[C@]12C)F)F)C(=O)COC(=O)C
  • InChi: 1S/C25H30F2O7/c1-13(28)33-12-21(32)24(34-14(2)29)8-6-16-17-10-19(26)18-9-15(30)5-7-22(18,3)25(17,27)20(31)11-23(16,24)4/h5,7,9,16-17,19-20,31H,6,8,10-12H2,1-4H3/t16-,17-,19+,20-,22-,23-,24-,25-/m0/s1
  • InChiKey: RWKMFNKALGKSFN-CYBFZDFUSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [(6R,8S,9R,10S,11S,13S,14S,17R)-17-(2-acetoxyacetyl)-6,9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] acetate
  • acetic acid [(6R,8S,9R,10S,11S,13S,14S,17R)-17-(2-acetoxy-1-oxoethyl)-6,9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] ester
  • acetic acid [(6R,8S,9R,10S,11S,13S,14S,17R)-17-(2-acetoxyacetyl)-6,9-difluoro-11-hydroxy-3-keto-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] ester
  • [(6R,8S,9R,10S,11S,13S,14S,17R)-17-(2-acetyloxyethanoyl)-6,9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] ethanoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.01 0.2316 0.2316
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0026 0.0244 0.0323
Toxoplasma gondii ribonuclease HI protein 0.0024 0.0196 0.0525
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0627 0.0829
Schistosoma mansoni hypothetical protein 0.0058 0.1152 0.112
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0026 0.0244 0.0209
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1577 0.1547
Echinococcus multilocularis snurportin 1 0.0372 1 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.0099 0.0064
Entamoeba histolytica hypothetical protein 0.0028 0.0305 0.3044
Onchocerca volvulus Cathepsin L homolog 0.002 0.0078 0.0382
Brugia malayi bHLH-PAS transcription factor 0.0043 0.0735 0.0971
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.004 0.0627 0.0594
Schistosoma mansoni ran 0.0026 0.0231 0.0196
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase isozyme 0.0033 0.0432 0.0398
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1682 0.7173
Brugia malayi nuclear hormone receptor 0.0019 0.0036 0.0047
Schistosoma mansoni survival motor neuron protein 0.0058 0.1152 0.112
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0036 0.0047
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0231 0.0196
Trypanosoma cruzi ribonuclease H1, putative 0.0024 0.0196 0.0653
Echinococcus granulosus ornithine aminotransferase 0.0026 0.0244 0.0209
Echinococcus granulosus Aminotransferase class III 0.0026 0.0244 0.0209
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0184 0.4689 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.004 0.0627 0.0594
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.049 0.1944
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.004 0.0627 0.0627
Echinococcus multilocularis thyroid hormone receptor alpha 0.004 0.0627 0.0594
Schistosoma mansoni thyroid hormone receptor 0.004 0.0627 0.0594
Loa Loa (eye worm) hypothetical protein 0.0021 0.0099 0.0099
Schistosoma mansoni Tr4/Tr2 (homologue) 0.004 0.0627 0.0594
Schistosoma mansoni coup transcription factor 0.004 0.0627 0.0594
Onchocerca volvulus 0.002 0.0078 0.0382
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0305 0.0491
Echinococcus multilocularis ribonuclease H1 0.0024 0.0196 0.0161
Schistosoma mansoni lamin 0.0033 0.0427 0.0392
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0627 0.0594
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0047 0.0047
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0099 0.0131
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0367 0.1401
Leishmania major cathepsin L-like protease 0.002 0.0078 0.0135
Brugia malayi Nuclear hormone receptor family member nhr-40 0.004 0.0627 0.0829
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0026 0.0244 0.0424
Echinococcus multilocularis ornithine aminotransferase 0.0026 0.0244 0.0209
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase isozyme L3 0.01 0.2326 1
Mycobacterium ulcerans acetylornithine aminotransferase 0.0026 0.0244 0.0424
Schistosoma mansoni hypothetical protein 0.0092 0.209 0.2062
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0734 0.0701
Brugia malayi Nuclear hormone receptor family member nhr-1 0.004 0.0627 0.0829
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.004 0.0627 0.0594
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0026 0.0255 0.091
Loa Loa (eye worm) hypothetical protein 0.0021 0.0099 0.0099
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0078 0.0078
Loa Loa (eye worm) ubiquitin C-terminal hydrolase UCH-L5 0.0033 0.0432 0.0432
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0627 0.0829
Leishmania major ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C12, putative 0.0033 0.0432 0.1688
Brugia malayi RNA, U transporter 1 0.0099 0.2303 0.3042
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase isozyme 0.01 0.2326 0.2299
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.004 0.0627 0.0594
Brugia malayi nuclear receptor NHR-88 0.004 0.0627 0.0829
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0033 0.0432 0.1688
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1577 0.3296
Brugia malayi Cytochrome P450 family protein 0.0019 0.0047 0.0063
Schistosoma mansoni nuclear hormone receptor 0.004 0.0627 0.0594
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0036 0.0036
Brugia malayi hypothetical protein 0.002 0.0062 0.0082
Brugia malayi hypothetical protein 0.0043 0.0734 0.097
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.004 0.0627 0.0594
Brugia malayi RNase H family protein 0.0024 0.0196 0.0259
Brugia malayi steroid hormone receptor 0.004 0.0627 0.0829
Brugia malayi Importin beta-1 subunit 0.0035 0.049 0.0648
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase BAP1 0.0033 0.0432 0.0398
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1577 0.3296
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.004 0.0627 0.0627
Loa Loa (eye worm) hypothetical protein 0.0019 0.0036 0.0036
Brugia malayi Steroid receptor seven-up type 2 0.004 0.0627 0.0829
Schistosoma mansoni hypothetical protein 0.0372 1 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0734 0.0701
Leishmania major cathepsin L-like protease 0.0077 0.1682 0.7173
Schistosoma mansoni lamin 0.0033 0.0427 0.0392
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0026 0.0244 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0036 0.0036
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0078 0.0043
Brugia malayi hypothetical protein 0.0286 0.7568 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0078 0.0043
Loa Loa (eye worm) ctsf protein 0.002 0.0078 0.0078
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0078 0.0043
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1682 0.7173
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0036 0.0036
Leishmania major cathepsin L-like protease 0.0077 0.1682 0.7173
Trypanosoma cruzi ribonuclease H1, putative 0.0024 0.0196 0.0653
Onchocerca volvulus 0.004 0.0627 0.53
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0026 0.0244 0.0738
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0231 0.0805
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.01 0.2326 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0231 0.0805
Echinococcus multilocularis ornithine aminotransferase 0.0026 0.0244 0.0209
Loa Loa (eye worm) hypoxia-induced factor 1 0.0182 0.464 0.464
Loa Loa (eye worm) hypothetical protein 0.0021 0.0099 0.0099
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0078 0.0043
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0367 0.1283
Schistosoma mansoni ubiquitinyl hydrolase-BAP1 (C12 family) 0.0033 0.0432 0.0398
Schistosoma mansoni single-minded 0.0059 0.1166 0.1134
Schistosoma mansoni family C12 unassigned peptidase (C12 family) 0.01 0.2326 0.2299
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0627 0.0829
Echinococcus granulosus lamin 0.0033 0.0427 0.0392
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0047 0.0822 0.3397
Brugia malayi RNase H family protein 0.0024 0.0196 0.0259
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0078 0.0043
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.0044 0.0738 1
Entamoeba histolytica hypothetical protein 0.0043 0.0734 0.882
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.004 0.0627 0.0627
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.004 0.0627 0.0594
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0036 0.0047
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0047 0.0822 0.3397
Brugia malayi conserved hypotetical protein 0.0019 0.0036 0.0047
Loa Loa (eye worm) hypothetical protein 0.004 0.0627 0.0627
Echinococcus granulosus retinoic acid receptor rxr beta a 0.004 0.0627 0.0594
Leishmania major hypothetical protein, conserved 0.003 0.0367 0.1401
Treponema pallidum ribonuclease H (rnhA) 0.0024 0.0196 0.5
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0305 0.0491
Entamoeba histolytica hypothetical protein 0.0043 0.0734 0.882
Leishmania major importin beta-1 subunit, putative 0.0028 0.0305 0.1128
Leishmania major ribonuclease H1, putative 0.0024 0.0196 0.0653
Trypanosoma brucei ingi protein (ORF1) 0.0026 0.0255 0.091
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.004 0.0627 0.0627
Entamoeba histolytica hypothetical protein 0.0043 0.0734 0.882
Loa Loa (eye worm) hypothetical protein 0.004 0.0627 0.0627
Plasmodium vivax importin-beta 2, putative 0.0035 0.049 0.1833
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0427 0.0427
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1682 0.7173
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1682 0.7173
Trypanosoma cruzi cysteine peptidase, Clan CA, family C19, putative 0.0031 0.0372 0.1422
Brugia malayi RNase H family protein 0.0024 0.0196 0.0259
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase isozyme L3, putative 0.01 0.2326 1
Loa Loa (eye worm) steroid hormone receptor 0.004 0.0627 0.0627
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0047 0.0822 0.1612
Onchocerca volvulus 0.002 0.0078 0.0382
Schistosoma mansoni aryl hydrocarbon receptor 0.0059 0.1166 0.1134
Trichomonas vaginalis Clan CA, family C12, ubiquitin hydrolase-like cysteine peptidase 0.01 0.2326 0.4875
Schistosoma mansoni importin beta-1 0.0035 0.049 0.0456
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0367 0.1283
Leishmania major GTP-binding protein, putative 0.0026 0.0231 0.0805
Plasmodium vivax ornithine aminotransferase, putative 0.0026 0.0244 0.0738
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.004 0.0627 0.0627
Brugia malayi photoreceptor-specific nuclear receptor 0.004 0.0627 0.0829
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.004 0.0627 0.0627
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0231 0.0805
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0255 0.091
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.004 0.0627 0.0594
Brugia malayi nuclear receptor RXR 0.0021 0.0099 0.0131
Loa Loa (eye worm) hypothetical protein 0.0019 0.0036 0.0036
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0734 0.0701
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.049 0.1833
Brugia malayi nuclear receptor NHR-67 0.0019 0.0036 0.0047
Echinococcus multilocularis importin subunit beta 1 0.0035 0.049 0.0456
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0427 0.0564
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0305 0.0491
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.004 0.0627 0.0627
Loa Loa (eye worm) hypothetical protein 0.0019 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0019 0.0036 0.0036
Echinococcus multilocularis lamin 0.0033 0.0427 0.0392
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1682 0.7173
Loa Loa (eye worm) hypothetical protein 0.0019 0.0036 0.0036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1682 0.7173
Echinococcus multilocularis ecdysone induced protein 78C 0.004 0.0627 0.0594
Loa Loa (eye worm) hypothetical protein 0.0033 0.0427 0.0427
Brugia malayi Cathepsin L-like precursor 0.002 0.0078 0.0103
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.004 0.0627 0.53
Schistosoma mansoni retinoic acid receptor RXR 0.004 0.0627 0.0594
Schistosoma mansoni ubiquitin-specific peptidase 9X (C19 family) 0.0108 0.2544 0.2517
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.1577 0.6668
Brugia malayi Cathepsin L-like precursor 0.002 0.0078 0.0103
Schistosoma mansoni family C12 unassigned peptidase (C12 family) 0.01 0.2326 0.2299
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0026 0.0244 0.5
Trichomonas vaginalis ribonuclease H1, putative 0.0024 0.0196 0.0256
Brugia malayi Cytochrome P450 family protein 0.0019 0.0047 0.0063
Leishmania major cathepsin L-like protease 0.002 0.0078 0.0135
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.004 0.0627 0.0594
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0627 0.0829
Trypanosoma brucei RNA helicase, putative 0.0092 0.209 0.8965
Onchocerca volvulus Protein ultraspiracle homolog 0.004 0.0627 0.53
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0099 0.0064
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0627 0.0829
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0036 0.0047
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0033 0.0432 0.1688
Loa Loa (eye worm) hypothetical protein 0.0019 0.0036 0.0036
Schistosoma mansoni thyroid hormone receptor 0.004 0.0627 0.0594
Onchocerca volvulus 0.002 0.0078 0.0382
Echinococcus granulosus lamin dm0 0.0033 0.0427 0.0392
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1682 0.7173
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1682 0.7173
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase, putative 0.0033 0.0432 0.4759
Loa Loa (eye worm) hypothetical protein 0.004 0.0627 0.0627
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.1682 0.7173
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1577 0.1547
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0036 0.0047
Brugia malayi ubiquitin C-terminal hydrolase UCH-L5 0.0033 0.0432 0.0571
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0231 0.0305
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 5 0.0031 0.0372 0.0337
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase isozyme 0.0033 0.0432 0.0398
Loa Loa (eye worm) hypothetical protein 0.004 0.0627 0.0627
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.7568 0.7559
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0047 0.0822 0.3397
Loa Loa (eye worm) hypothetical protein 0.0019 0.0036 0.0036
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0047 0.0047
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0305 0.1128
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase UCHL3 0.01 0.2326 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1682 0.7173
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0231 0.0196
Entamoeba histolytica hypothetical protein 0.0033 0.0432 0.4759
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.004 0.0627 0.0594
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0078 0.0043
Echinococcus multilocularis Aminotransferase class III 0.0026 0.0244 0.0209
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0026 0.0244 0.0424
Onchocerca volvulus 0.002 0.0078 0.0382
Schistosoma mansoni family C12 unassigned peptidase (C12 family) 0.01 0.2326 0.2299
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0078 0.0043
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0078 0.0043
Loa Loa (eye worm) hypothetical protein 0.0019 0.0036 0.0036
Onchocerca volvulus 0.002 0.0078 0.0382
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1682 0.7173
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1682 0.7173
Loa Loa (eye worm) hypothetical protein 0.01 0.2316 0.2316
Mycobacterium ulcerans putative regulatory protein 0.0043 0.0735 0.1481
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0231 0.0679
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.004 0.0627 0.0594
Trypanosoma brucei ingi protein (ORF1) 0.0026 0.0255 0.091
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.1152 0.1522
Schistosoma mansoni ubiquitinyl hydrolase-UCH37 (C12 family) 0.0033 0.0432 0.0398
Brugia malayi Nuclear hormone receptor family member nhr-31 0.004 0.0627 0.0829
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0367 0.1283
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0099 0.0131
Brugia malayi hypothetical protein 0.0197 0.5071 0.67
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.01 0.2326 1
Echinococcus multilocularis transfer RNA-Lys 0.0043 0.0735 0.0702
Plasmodium vivax ubiquitin C-terminal hydrolase, family 1, putative 0.0033 0.0432 0.1574
Brugia malayi Nuclear hormone receptor family member nhr-41 0.004 0.0627 0.0829
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 0.0108 0.2544 0.2517
Brugia malayi hypothetical protein 0.0019 0.0036 0.0047
Echinococcus granulosus cathepsin l1 0.002 0.0078 0.0043
Loa Loa (eye worm) hypothetical protein 0.002 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.003 0.0367 0.0367
Echinococcus multilocularis cysteine protease 0.002 0.0078 0.0043
Echinococcus granulosus ribonuclease H1 0.0024 0.0196 0.0161
Onchocerca volvulus Cathepsin F homolog 0.002 0.0078 0.0382
Trichomonas vaginalis Clan CA, family C12, ubiquitin hydrolase-like cysteine peptidase 0.01 0.2326 0.4875
Schistosoma mansoni phosphoglucomutase 0.0024 0.0196 0.0161
Onchocerca volvulus 0.002 0.0078 0.0382
Loa Loa (eye worm) hypothetical protein 0.0286 0.7568 0.7568
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0627 0.0594
Brugia malayi intermediate filament protein 0.0033 0.0427 0.0564
Leishmania major ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C12, putative 0.01 0.2326 1
Leishmania major cysteine peptidase A (CPA) 0.002 0.0078 0.0135
Schistosoma mansoni ran 0.0026 0.0231 0.0196
Brugia malayi ecdysone receptor 0.0019 0.0036 0.0047
Echinococcus multilocularis musashi 0.0033 0.0427 0.0392
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0026 0.0244 0.0424
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0108 0.2544 0.3361
Brugia malayi hypothetical protein 0.003 0.0367 0.0485
Brugia malayi PAS domain containing protein 0.0059 0.1166 0.154
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0184 0.4689 1
Leishmania major cathepsin L-like protease 0.0077 0.1682 0.7173
Loa Loa (eye worm) hypothetical protein 0.01 0.2316 0.2316
Brugia malayi hypothetical protein 0.0021 0.0099 0.0131
Schistosoma mansoni steroid hormone receptor ad4bp 0.004 0.0627 0.0594
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase 5, putative 0.0047 0.0822 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.1577 0.6713
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.1217 0.5131
Loa Loa (eye worm) fibroinase 0.002 0.0078 0.0078
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 1 1
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0044 0.0738 0.0738
Leishmania major cathepsin L-like protease 0.002 0.0078 0.0135
Brugia malayi hypothetical protein 0.0019 0.0036 0.0047
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.0047 0.0822 0.0789
Entamoeba histolytica hypothetical protein 0.0043 0.0734 0.882
Echinococcus granulosus FTZ F1 alpha 0.004 0.0627 0.0594
Brugia malayi ecdysteroid receptor 0.004 0.0627 0.0829
Entamoeba histolytica Ran family GTPase 0.0026 0.0231 0.2053
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0047 0.0047
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0099 0.0064
Plasmodium falciparum ornithine aminotransferase 0.0026 0.0244 0.0738
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0627 0.0829
Echinococcus granulosus single minded 2 0.0043 0.0735 0.0702
Mycobacterium ulcerans L-lysine aminotransferase 0.0026 0.0244 0.0424
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0047 0.0822 0.0789
Mycobacterium ulcerans hypothetical protein 0.0184 0.4689 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.049 0.1944
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.0099 0.0099
Schistosoma mansoni RAR-like nuclear receptor 0.004 0.0627 0.0594
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.0627 0.0594
Brugia malayi nuclear receptor NHR-88 0.0019 0.0036 0.0047
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.0099 0.0064
Loa Loa (eye worm) hypothetical protein 0.004 0.0627 0.0627
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0231 0.0679
Loa Loa (eye worm) hypothetical protein 0.0197 0.5071 0.5071
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.1577 0.1547
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0026 0.0244 0.0424
Loa Loa (eye worm) hypothetical protein 0.0108 0.2544 0.2544
Brugia malayi hypothetical protein 0.0021 0.0099 0.0131
Echinococcus multilocularis FTZ F1 alpha 0.004 0.0627 0.0594
Echinococcus granulosus ecdysone induced protein 78C 0.004 0.0627 0.0594
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0367 0.1283
Onchocerca volvulus 0.0033 0.0427 0.3505
Brugia malayi Cathepsin L-like precursor 0.002 0.0078 0.0103
Loa Loa (eye worm) hypothetical protein 0.0019 0.0036 0.0036
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1682 0.7173
Brugia malayi nuclear receptor RXR 0.0019 0.0036 0.0047
Onchocerca volvulus 0.002 0.0078 0.0382
Schistosoma mansoni ubiquitinyl hydrolase-UCH37 (C12 family) 0.0033 0.0432 0.0398
Schistosoma mansoni phosphoglucomutase 0.0024 0.0196 0.0161
Echinococcus granulosus intermediate filament protein 0.0033 0.0427 0.0392
Brugia malayi hypoxia-induced factor 1 0.0182 0.464 0.6131
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase isozyme 0.0033 0.0432 0.0398
Schistosoma mansoni hypothetical protein 0.0043 0.0734 0.0701
Brugia malayi Ubiquitin carboxyl-terminal hydrolase, family 1 protein 0.01 0.2326 0.3074
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.1577 0.1547
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0036 0.0047
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 13, putative 0.0044 0.0738 0.2935
Loa Loa (eye worm) hypothetical protein 0.01 0.2316 0.2316
Onchocerca volvulus Ribonuclease H1 homolog 0.0024 0.0196 0.1439
Leishmania major cathepsin L-like protease 0.002 0.0078 0.0135
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0231 0.0231
Loa Loa (eye worm) DR-78 0.0019 0.0036 0.0036
Plasmodium falciparum importin beta, putative 0.0035 0.049 0.1833
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0033 0.0432 0.1688
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0078 0.0135
Brugia malayi Nuclear hormone receptor family member nhr-14 0.004 0.0627 0.0829
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase BAP1 0.0033 0.0432 0.0398
Loa Loa (eye worm) hypothetical protein 0.0019 0.0036 0.0036
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0184 0.4689 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0627 0.0594
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0044 0.0738 0.0975
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.004 0.0627 0.0594
Loa Loa (eye worm) hypothetical protein 0.004 0.0627 0.0627
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 5 0.0042 0.0683 0.0649
Onchocerca volvulus 0.0043 0.0735 0.6265
Trypanosoma brucei ribonuclease H1 0.0024 0.0196 0.0653
Echinococcus multilocularis lamin dm0 0.0033 0.0427 0.0392
Trypanosoma cruzi cysteine peptidase, Clan CA, family C19, putative 0.0042 0.0683 0.2787
Schistosoma mansoni phosphoglucomutase 0.0024 0.0196 0.0161
Echinococcus granulosus importin subunit beta 1 0.0035 0.049 0.0456
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0036 0.0047
Onchocerca volvulus 0.0033 0.0427 0.3505
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 13, putative 0.0044 0.0738 0.2935
Loa Loa (eye worm) hypothetical protein 0.0021 0.0099 0.0099
Brugia malayi Cathepsin L-like precursor 0.002 0.0078 0.0103
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0078 0.0103
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1577 0.3296
Loa Loa (eye worm) hypothetical protein 0.01 0.2316 0.2316
Loa Loa (eye worm) hypothetical protein 0.0019 0.0036 0.0036
Brugia malayi tailless protein 0.0019 0.0036 0.0047
Onchocerca volvulus Bile acid receptor homolog 0.004 0.0627 0.53
Brugia malayi nuclear hormone receptor 0.004 0.0627 0.0829
Trypanosoma brucei unspecified product 0.0026 0.0255 0.091
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 0.0108 0.2544 0.2517
Leishmania major cathepsin L-like protease 0.002 0.0078 0.0135
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0627 0.0594
Loa Loa (eye worm) hypothetical protein 0.004 0.0627 0.0627
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1682 0.7173
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0184 0.4689 1
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.7568 0.7559
Schistosoma mansoni intermediate filament proteins 0.0033 0.0427 0.0392
Loa Loa (eye worm) hypothetical protein 0.0019 0.0036 0.0036
Trichomonas vaginalis ran, putative 0.0026 0.0231 0.0331
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0367 0.1401
Mycobacterium tuberculosis Probable aminotransferase 0.0184 0.4689 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0627 0.0627
Toxoplasma gondii UBA/TS-N domain-containing protein 0.0047 0.0822 0.3307
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0231 0.0639
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.1493 0.6345
Brugia malayi Nuclear hormone receptor family member nhr-49 0.004 0.0627 0.0829
Loa Loa (eye worm) hypothetical protein 0.0021 0.0099 0.0099
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.1577 0.2999
Loa Loa (eye worm) hypothetical protein 0.0032 0.041 0.041
Brugia malayi Cathepsin L-like precursor 0.002 0.0078 0.0103
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0627 0.0829
Brugia malayi Cathepsin L-like precursor 0.002 0.0078 0.0103
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase, family 1 protein 0.0033 0.0432 0.1574
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase isozyme 0.01 0.2326 0.2299
Loa Loa (eye worm) hypothetical protein 0.0031 0.0372 0.0372
Onchocerca volvulus Cathepsin L homolog 0.002 0.0078 0.0382
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.004 0.0627 0.0594
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1682 0.7173
Brugia malayi Nuclear hormone receptor family member nhr-3 0.004 0.0627 0.0829
Loa Loa (eye worm) hypothetical protein 0.0035 0.049 0.049
Echinococcus multilocularis cysteine protease 0.002 0.0078 0.0043
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0367 0.1401
Loa Loa (eye worm) hypothetical protein 0.0019 0.0036 0.0036
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 5 0.0031 0.0372 0.0337
Plasmodium falciparum deubiquinating/deneddylating enzyme 0.0033 0.0432 0.1574
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0078 0.0078
Onchocerca volvulus 0.0058 0.1152 1
Loa Loa (eye worm) hypothetical protein 0.01 0.2326 0.2326
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0231 0.0679
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0427 0.0427
Loa Loa (eye worm) cysteine protease 0.002 0.0078 0.0078

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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